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Dissertations / Theses on the topic 'Regulatory Affair'

Author: Grafiati

Published: 21 February 2023

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1

Villa, Federico. "The determinants of market access for medicines: theoretical issues and empirical evidence." Doctoral thesis, Università del Piemonte Orientale, 2021. https://hdl.handle.net/11579/148544.

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To frame the determinants of drug prices within a complex regulatory system and how these determinants influence the P&R decisions of medicine, an analysis of the Italian reference context as a whole was done, starting from the trends in the use and consumption of drugs, to the analysis of the regulatory process and market access for specific categories of drugs, orphan drugs for rare diseases. Some of the system's shortcomings are the result of limited quality control as a whole over the years, which has led to the adoption of compartmentalized pharmaceutical policies without a medium-long t

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Costa, Sara Filipa Abrantes. "Training in regulatory strategy and regulatory affairs of health products." Master's thesis, Universidade de Aveiro, 2012. http://hdl.handle.net/10773/10587.

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Mestrado em Biomedicina Farmacêutica<br>O presente relatório descreve as atividades desenvolvidas como estagiária no departamento de Estratégia e Assuntos Regulamentares da empresa Eurotrials, Consultores Científicos, empresa especializada na investigação clínica e consultoria científica na área da saúde. O objetivo principal desta experiência de 9 meses era um primeiro contacto com mundo do trabalho, consolidando e aprofundando os conteúdos abordados no Mestrado em Biomedicina Farmacêutica. Os Assuntos Regulamentares estão fortemente envolvidos em todo o processo de desenvolvimento do produ

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Dhanraj, Keshnee. "Perceptions of the pharmaceutical industry and regulators in South Africa towards registration harmonisation in the Southern African Development Community (SADC)." University of the Western Cape, 2021. http://hdl.handle.net/11394/7956.

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Magister Pharmaceuticae - MPharm<br>Medicines have to be regulated in an effort to monitor their quality, safety, and efficacy. The process of medicines registration is lengthy, costly, and document-heavy. Many countries have limited expertise and resources at national medicines regulatory authorities (NMRAs) and some countries have adopted unified approaches to medicines registration legislation. Harmonised guidelines and initiatives have been adopted in South Africa and the Southern African Development Community (SADC). However, there are no studies that have identified the effects of

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Pinho, Bárbara Marina da Silva. "Regulatory affairs role in a multinational pharmaceutical company." Master's thesis, Universidade de Aveiro, 2014. http://hdl.handle.net/10773/12967.

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Mestrado em Biomedicina Farmacêutica<br>The present monograph intends to present a Regulatory Affairs department at a Multinational Pharmaceutical Company, as well as the role of the professionals working in that department. The experience which led to this monograph occurred after the conclusion of the curricular part of the Masters in Pharmaceutical Medicine, and was an opportunity to apply all the knowledge previously acquired and to develop new technical and personal skills. After the contextualisation of this document, the first chapter of this monograph introduce the Regulatory Affairs P

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Pinela, Raquel Alexandra Pires. "9 months experience as a trainee regulatory affairs officer." Master's thesis, Universidade de Aveiro, 2012. http://hdl.handle.net/10773/10900.

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Mestrado em Biomedicina Farmacêutica<br>O presente relatório tem como objetivo descrever as atividades desenvolvidas no âmbito do estágio curricular na área dos assuntos regulamentares, que decorreu entre 1 de Agosto de 2011 e 4 de Maio de 2012, no Departamento de Manutenção do Mercado da Phagecon – Serviços e Consultoria Farmacêutica, Lda.. Este estágio é parte integrante do programa de formação do mestrado em Biomedicina Farmacêutica e teve como principais objetivos a aquisição de experiência na realização das atividades comumente associadas aos assuntos regulamentares, bem como a consolidaç

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Mukoma, Collins. "Exploration of the Training/Educational Background and The Roles of Regulatory Affairs Associates/Officers in selected South African Based Pharmaceutical Companies in Gauteng Province." University of the Western Cape, 2004. http://hdl.handle.net/11394/8235.

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>Magister Scientiae - MSc<br>Regulatory Affairs (RA), within the pharmaceutical business, could be a profession that covers completely different registration parameters of a pharmaceutical product. This is often a replacement profession that was developed to shield public health by providing the smart quality pharmaceutical product as well as safety and efficacy. The study aimed to explore the coaching and role of RA associates/officers in pharmaceutical corporations in Gauteng, South Africa. The study was a cross-sectional survey, which utilized google forms with both open and closed-ended qu

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Kachirskaia, Ioulia. "Identifying a potential substrate of Plasmodium Falciparum cell cycle regulatory Kinase PFPK5." Honors in the Major Thesis, University of Central Florida, 2003. http://digital.library.ucf.edu/cdm/ref/collection/ETH/id/321.

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This item is only available in print in the UCF Libraries. If this is your Honors Thesis, you can help us make it available online for use by researchers around the world by following the instructions on the distribution consent form at http://library.ucf.edu/Systems/DigitalInitiatives/DigitalCollections/InternetDistributionConsentAgreementForm.pdf You may also contact the project coordinator, Kerri Bottorff, at kerri.bottorff@ucf.edu for more information.<br>Bachelors<br>Health and Public Affairs<br>Molecular Biology and Microbiology

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Bodnar, Olivia Verfasser], and Justus [Gutachter] [Haucap. "Five Empirical Essays on Antitrust and Regulatory Affairs / Olivia Bodnar ; Gutachter: Justus Haucap." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2021. http://d-nb.info/1224679326/34.

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Williams, George. "Establishing an effective economic regulatory policy for the European airline industry." Thesis, Cranfield University, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.278751.

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Gooch, Rebecca L. "Television production, regulation and enforcement reasons for broadcasters' non-compliance and a weakened state of regulatory affairs." Thesis, London School of Economics and Political Science (University of London), 2012. http://etheses.lse.ac.uk/353/.

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This thesis examines a group of television-makers that aimed to circumvent the regulations affecting standards of content and to reshape the boundaries of permissible violent content. It also examines the regulators who, in a period of significant regulatory restructuring, were required to police those boundaries and protect viewers from ‘harmful’ or ‘offensive’ content, and programme-contributors from ‘unfair’ treatment. In doing so, the aim is to offer a broader, empirically rich understanding of the individual, organisational and external factors that can lead to non-compliance and the rela

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Maloney, William A. "The politics and dynamics of organisational and regulatory change in the water industry in England and Wales 1945-1993." Thesis, University of Strathclyde, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.389973.

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Laaroubi, Khalid. "Étude biochimique et moléculaire du facteur de croissance heparin affin regulatory peptide (HARP)." Paris 12, 1995. http://www.theses.fr/1995PA120013.

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Depuis plusieurs annees, notre laboratoire s'interesse aux facteurs de croissance ayant une affinite pour l'heparine. Notre experience dans ce domaine, ainsi que la disponibilite tres recente de differentes techniques d'analyses, nous a amenes a la detection puis a la purification a partir d'extraits de cerveau de buf adulte, d'une nouvelle molecule de 18 kda nommee harp. Nous avons decrit harp comme un facteur de croissance ayant des activites mitogene et neurotrophe. Son activite mitogene a par la suite ete remise en question par certains groupes qui, pour des raisons inconnues n'ont pu la m

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Mrazek, Monique Francine. "The impact of differing regulatory frameworks on post-patent pharmaceutical markets in the United Kingdom, United States and Germany 1990 to 1997." Thesis, London School of Economics and Political Science (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.391052.

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This thesis analysed the effects of different regulatory frameworks on the post-patent pharmaceutical markets of the United Kingdom, Germany and the United States between 1990 and 1997. Firstly, an extensive search of peer reviewed and 'grey' literature was undertaken to develop an understanding of both the pharmaceutical and wider health policy environments during the period of study. Preference was given to prospective before and after studies with and without control groups, retrospective studies with and without controls, and case studies that were reinforced by similar supporting case stu

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Augusto, Ana Isabel Santos. "Curricular internship in a clinical pharmacology unit." Master's thesis, Universidade de Aveiro, 2015. http://hdl.handle.net/10773/14882.

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Mestrado em Biomedicina Farmacêutica<br>The present internship report is a detailed description of my experience in the curricular internship performed at the Clinical Pharmacology Unit of the Instituto de Medicina Molecular, from October 13th 2014 to June 5th 2015. This internship was performed as part of the second and final year of the Master’s Degree in Pharmaceutical Biomedicine of the University of Aveiro. During the course of the experience I had the opportunity to participate in several projects in collaboration with different teams, most relevantly the activities related to the

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Jacobs, Debra. "Do State Regulatory Institutions Matter: Using Network Theory to Explore Linkages between Air Policy Boards and Pollution Outcomes." VCU Scholars Compass, 2009. http://scholarscompass.vcu.edu/etd/2040.

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The purpose of this study is to test an adapted model of network theory against state air pollution control institutions. Air pollution control presents a regulatory problem that has interstate, intrastate and multiple federal dimensions. It is one of extreme complexity and uncertainty, from both a regulatory and scientific perspective. The changing political environment federally has enabled states to redefine their roles in the regulatory process (Adler, 1997; Krane, 2007). Drawing from network theory in intergovernmental policy processes my research tests three key factors in explaini

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Rehnström, Ida. "MedTech Firms' Business Model Alignment with Healthcare Institutional Logic : Successful Commercialization." Thesis, Luleå tekniska universitet, Institutionen för ekonomi, teknik och samhälle, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:ltu:diva-85334.

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MedTech firms experience barriers when entering the healthcare sector, although their solutions could solve healthcare challenges. The study provides a conceptual framework for MedTech firms' business environment including institutional alignments and misalignments. These insights support MedTech firms' business model development when aiming for successful commercialization. The research is conducted with a multiple case study analyzing MedTech firms' and healthcare organizations' perspective regarding the business environment and relationship dynamics. The study generated three main findings.

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Bernard-Pierrot, Isabelle. "Mise en évidence de déterminants structuraux impliqués dans les activité biologiques du facteur de croissance HARP (Heparin affin regulatory peptide)." Paris 11, 2002. http://www.theses.fr/2002PA11T027.

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L'HARP (Beparin Affin Regulatory Peptide) est un facteur de croissance de 18 kDa, se liant à l'héparine, fortement exprimé dans les tumeurs primaires humaines d'origine mammaire, gastro-intestinale et prostatique. L'HARP est considéré comme un facteur angiogène favorisant la progression tumorale et la dissémination métastasique. Son implication dans le processus tumoral est liée à ses activités mitogène, angiogène et transformante. L'HARP induit également, in vitro, la croissance neuritique de neurones embryonnaires de rat. Nos travaux, visant à corréler la structure de la protéine avec ses ac

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Héroult, Mélanie. "Etude de la modélisation de l'angiogénèse par le facteur de croissance "Heparin Affin Regulatory Peptide" : implication dans les pathologies arthritiques." Paris 12, 2002. http://www.theses.fr/2002PA120002.

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L'angiogenèse est un processus dynamique par lequel de nouveaux capillaires sanguins sont formés par excroissance de vaisseaux pré-existants et qui est associé au développement de nombreuses pathologies prolifératives. Le but de cette étude a é d'identifier les différents domaines structuraux du facteur de croissance Heparin Affin Regulatory peptide (HARP) impliqués dans 1' angiogenèse et de rechercher la présence d'HARP dans certaines pathologies rhumatismales où le processus angiogène est déterminant. Dans cette étude, nous avons mis en évidence que I'HARP et des peptides correspondants aux

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Andam, Kwaw Senyi. "Essays on the Evaluation of Land Use Policy: The Effects of Regulatory Protection on Land Use and Social Welfare." Digital Archive @ GSU, 2007. http://digitalarchive.gsu.edu/pmap_diss/20.

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Societies frequently implement land use policies to regulate resource extraction or to regulate development. However, two important policy questions remain unresolved. First, how effective are land use regulations? Second, how do land use regulations affect socioeconomic conditions? Three issues complicate the evaluation of land use policies: (1) overt bias may lead to incorrect estimates of policy effects if implementation is nonrandom; (2) the policy may affect outcomes in neighboring unregulated lands; and (3) unobservable differences between regulated and unregulated lands may lead to bias

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Bouderlique, Thibault. "Etude des propriétés ostéoinductrices et chondroinductrices de "l'Heparin affin regulatory peptide" sur les cellules stromales mésenchymateuses humaines, application en régénération osseuse." Phd thesis, Université Paris-Est, 2012. http://tel.archives-ouvertes.fr/tel-00904131.

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La régénération osseuse est un processus impliquant de nombreux types cellulaires comme les ostéoblastes, les chondrocytes ou les cellules stromales mésenchymateuses (CSM). Les CSM possèdent des capacités de différenciation suggérant leur implication dans ce processus de réparation. La régénération osseuse est le fruit de la coordination complexe de l'activité de nombreux facteurs de croissance. Parmi eux, l'" Heparin affin regulatory peptide " (HARP) est fortement exprimé dans le callus durant la régénération mais son rôle n'est pas clairement établi. Le but de ce travail de thèse a été (1) d

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Zhang, Lei. "Uncompensated Care Provision and the Economic Behavior of Hospitals: the Influence of the Regulatory Environment." Diss., unrestricted, 2008. http://etd.gsu.edu/theses/available/etd-02242009-152847/.

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Thesis (Ph. D.)--Georgia State University, 2008.<br>Title from file title page. Paul G. Farnham, committee chair; Patricia G. Ketsche , Douglas S. Noonan (Ga. Tech.), Shiferaw Gurmu, Karen J. Minyard, William S. Custer, committee members. Description based on contents viewed June 11, 2009. Includes bibliographical references (p. 146-153).

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Elahouel, Rania. "Le Fibroblast Growth Factor 2 ( FGF-2 ) et la neuropiline-1 (NRP-1) : nouveaux partenaires moléculaires de Heparin Affin Regulatory Peptide ( HARP)." Thesis, Paris Est, 2012. http://www.theses.fr/2012PEST0066.

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HARP (Heparin Affin regulatory peptide) est un facteur de croissance qui constitue avec la midkine une sous-famille des Heparin Binding Growth Factors (HBGFs). HARP est impliqué dans de nombreux processus physiologiques comme la neurogenèse et la vasculogenèse mais aussi dans des processus physiopathologiques comme l’angiogenèse et la progression tumorale. HARP interagit avec différents récepteurs (N-syndécan, RPTPβ/ζ, et ALK). Plus récemment, il a été montré au laboratoire que la nucléoline, protéine navette entre le noyau, le cytoplasme, et la surface cellulaire est un nouveau récepteur à HA

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Dreker, David, and Jacqueline Lampey. "Policy Instruments and their Impact on Business Practice in the Fashion Industry towards Sustainability : Learning Outcomes from the Food Industry." Thesis, Högskolan i Borås, Akademin för textil, teknik och ekonomi, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:hb:diva-22107.

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The fashion industry is not only known for its creativity and innovation, but also for its contribution to environmental pollution, climate change as well as for social imbalances and poverty. Ecological and societal standards have so far only played a minor role in this industry for production and distribution as well as for consumers for their consumption and disposal behaviour. However, in order to achieve the UN Sustainable Development Goals and prevent the maximum damage caused by pollution and exploitation, it is necessary to act more rapidly and consistently. Governmental control instru

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Bellan, Natália. "Diretrizes para o processo de registro sanitário dos medicamentos." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/9/9139/tde-30072015-100420/.

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O controle sanitário no Brasil merece elevado nível de consideração, pois caracteriza-se por grande importância social e econômica. Abrange um leque grande de produtos e serviços de diversas naturezas, como: medicamentos, alimentos, produtos biológicos, vacinas, hemoderivados, saneantes e desinfetantes, produtos de higiene pessoal, perfumes e cosméticos, controle dos portos, aeroportos, estações de fronteiras e uma ampla variedade de serviços à saúde. A Agência Nacional de Vigilância Sanitária (ANVISA) foi criada no Brasil especificamente conforme artigo 3º da Lei nº 9782/1999, sendo relativam

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Vacherot, Francis. "Étude de l'activité mitogène du facteur de croissance Heparin Affin Regulatory Peptide (HARP) et de son implication dans la physiologie et la physiopathologie de la prostate." Paris 12, 1996. http://www.theses.fr/1996PA120020.

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Notre laboratoire a purifie a partir de cerveau de buf un facteur de croissance ayant une forte affinite pour l'heparine appele harp (heparin affin regulatory peptide) egalement connu sous le nom de ptn (pleiotrophin). In vitro, cette molecule induit la croissance neuritique des neurones embryonnaires et des cellules pc12. Harp est egalement capable d'induire la croissance des cellules endotheliales, fibroblastiques, epitheliales et musculaires lisses. Cependant cette activite mitogene est contestee, certains auteurs pretendant qu'elle reflete la presence de contaminants de type fgfs dans les

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Di, Francesco Dimitri. "La doctrine administrative de la commande publique." Thesis, Paris 2, 2018. http://www.theses.fr/2018PA020024.

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Contrairement à la doctrine fiscale, la doctrine administrative de la commande publique, quand bien même son assise est ancienne, n’a constitué que récemment un objet d’étude. Cependant, étant un outil essentiel pour les administrations, la doctrine administrative démontre à nouveau l’unilatéralité de l’action publique au motif qu’elle est l’instrumentum par lequel la direction des affaires juridiques des ministères économiques et financiers (DAJ) propose une interprétation de ce droit technique. Une étude empirique et prospective de cette doctrine administrative doit conduire à mettre en lumi

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Dos, Santos Célia. "Implication de la région C-terminale de l'Héparin Affin Regulatory Peptide (HARP) dans l'inhibition de la prolifération des glioblastomes et mise en évidence d'interactions entre ce facteur de croissance et d'autres Heparin Binding Growth Factors (HBGFs)." Paris 11, 2010. http://www.theses.fr/2010PA11T082.

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Tir, Nesym. "Evolution de la réglementation des institutions financières : de la lutte anti-blanchiment à la conformité." Thesis, Université Côte d'Azur (ComUE), 2019. http://www.theses.fr/2019AZUR0007.

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La mondialisation des échanges, générant un accroissement des volumes de transactions financières, a été accompagnée par une mondialisation des activités criminelles. Les techniques de blanchiment se sont adaptées à cette réalité économique. La lutte anti-blanchiment est intrinsèquement un sujet complexe qui a mobilisé une volonté d’architecture ouverte entre les acteurs publics et une interdépendance entre les régulateurs et les institutions financières. Son objectif est de viser l’action des organisations criminelles transnationales qui ont su tirer profit de la congruence entre la sophistic

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Kinuthia, Wanyee. "“Accumulation by Dispossession” by the Global Extractive Industry: The Case of Canada." Thèse, Université d'Ottawa / University of Ottawa, 2013. http://hdl.handle.net/10393/30170.

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This thesis draws on David Harvey’s concept of “accumulation by dispossession” and an international political economy (IPE) approach centred on the institutional arrangements and power structures that privilege certain actors and values, in order to critique current capitalist practices of primitive accumulation by the global corporate extractive industry. The thesis examines how accumulation by dispossession by the global extractive industry is facilitated by the “free entry” or “free mining” principle. It does so by focusing on Canada as a leader in the global extractive industry and the spr

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Chiu, Chun-Huei, and 邱君慧. "ASEAN Regulatory Affairs Study on Generic Drugs." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/zu3a3m.

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Moonsamy, Marlene Rose. "Correlation between tertiary education and pharmaceutical industry requirements for regulatory affairs pharmacists." Thesis, 2016. http://hdl.handle.net/10539/21549.

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A Research Report submitted to the Faculty of Health Sciences, University of Witwatersrand, Johannesburg, in fulfilment of the requirements for the degree of Master of Science in Medicine Pharmacotherapy June 2016<br>In the pharmaceutical sector, the health of the public is protected by medicines regulatory authorities who enforce regulatory practices to be executed by pharmaceutical companies. In South Africa, the Medicines Control Council (MCC) describes these practice requirements via guidelines, which are based on the Medicines and Related Substances Control Act 101 of 1965. The Reg

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Liu, Sin-Wei, and 劉欣維. "The regulatory affairs study on Health Food of Taiwan, China, USA and Australia." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/4um3da.

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碩士<br>中國醫藥大學<br>製藥碩士學位學程<br>106<br>As the economy and the standard of living improve, the demand for health and wellness is rapidly increasing. Under the influence of the traditional Chinese concept of health, the functional food grows quickly and becomes a flourishing industry in Taiwan. According to the flourishing of functional food industry, Taiwan government legislated the law of Health food to strengthen the supervision and control in 1999. However, there are only four hundred registered Health Foods until now. This study focused on the requirements that may be unsatisfied in the regulat

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Ding, Yu-Xing, and 丁宇星. "Shaping Regulatory Affairs Strategy in Animal Healthcare Industry at a Country Level: The Case of China." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/xx3egk.

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碩士<br>國立政治大學<br>國際經營管理英語碩士學位學程(IMBA)<br>107<br>The fast-growing global demand for livestock-derived products and pet health care has driven the animal healthcare industry to develop safe, efficacious, and high-quality veterinary medicinal products. The commercialization of most veterinary medicinal products, similar to human medicine, requires the marketing authorization from regulatory authorities. However, the complexities of regulatory environment and inconsistent regulatory requirement at different markets have still been a hurdle for multinational companies to rapidly bring new products t

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Δρόσου, Γεωργία. "Μελέτη του ρόλου του αυξητικού παράγοντα HARP (Heparin Affin Regulatory Peptide) στην αγγειογένεση in vivo". Thesis, 2007. http://nemertes.lis.upatras.gr/jspui/handle/10889/753.

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H HARP (heparin-affin regulatory peptide), γνωστή και ως πλειοτροπίνη (PTN), είναι ένας 18 kDa αυξητικός παράγοντας, ο οποίος έχει υψηλή συγγένεια για την ηπαρίνη. Η HARP έχει πολλαπλές βιολογικές δράσεις, όπως συμμετέχει στη ρύθμιση του κυτταρικού πολλαπλασιασμού, στη μετανάστευση και τη διαφοροποίηση. Επιπλέον η έκφραση της σχετίζεται με την φυσιολογική και καρκινική αγγειογένεση in vitro και in vivo. Στην παρούσα εργασία μελετήθηκε η έκφραση της HARP και των υποδοχέων της, ALK και RPTPβ/ζ, στις διάφορες ημέρες ανάπτυξης της CAM εμβρύου όρνιθας. Επίσης, μελετήθηκε η μείωση της έκφρασης της ε

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Dias, José Augusto Aleixo. "Contribution of medical affairs to an efficient management in the pharmaceutical industry." Doctoral thesis, 2019. http://hdl.handle.net/10773/25719.

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During the last decade the pharmaceutical industry (PI) operations became far more complex due to several structural and organizational changes, new legislation and pharmacoeconomic constraints. The role of Medical Affairs (MA) has been increasingly important and the interactions between PI and healthcare professionals (HCP) are currently much more based on science, than in marketing or commercial arguments. This thesis provides an in-depth description of the MA function, maps key areas of activity, challenges processes and opportunities, based on the feedback collected from PI profes

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Τριπολιτσιώτη, Δήμητρα. "Ο αυξητικός παράγοντας HARP (Heparin Affin Regulatory Peptide) ενεργοποιεί έμμεσα τον υποδοχέα ALK (Anaplastic Lymphoma Kinase)". 2013. http://hdl.handle.net/10889/6264.

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Η HARP (Heparin Affin Regulatory Peptide) είναι ένας αυξητικός παράγοντας που δεσμεύεται στην ηπαρίνη και εμπλέκεται στη ρύθμιση της κυτταρικής διαφοροποίησης, του κυτταρικού πολλαπλασιασμού καθώς και της αγγειογένεσης. Υψηλές συγκεντρώσεις του αυξητικού παράγοντα HARP έχουν βρεθεί σε ανθρώπινους καρκινικούς όγκους, σε καρκινικές κυτταρικές σειρές, όπως επίσης και σε ορό ασθενών με διάφορους τύπους καρκίνου. Επιπλέον, είναι γνωστό ότι η HARP αποτελεί υπόστρωμα για διάφορα πρωτεολυτικά ένζυμα του κυτταρικού μικροπεριβάλλοντος, με αποτέλεσμα την παραγωγή ενεργών πεπτιδίων που μπορούν να έχουν πα

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Torres, João Diogo Basso da Silva. "Intership Reports and Monograph titled "Understanding Quality by Design with Monoclonal Antibodies"." Master's thesis, 2017. http://hdl.handle.net/10316/83771.

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Relatório de Estágio do Mestrado Integrado em Ciências Farmacêuticas apresentado à Faculdade de Farmácia<br>O presente documento compreende os Relatórios de Estágio em Farmácia Comunitária e em Assuntos Regulamentares e Farmacovigilância, e a monografia intitulada "Understanding Quality by Design with Monoclonal Antibodies". Para cada relatório, foi realizada uma análise SWOT. Quality by Design não é um conceito novo para a Indústria Farmacêutica. De facto, foi introduzido na ICH Q8 como uma abordagem melhorada para o Desenvolvimento Farmacêutico, substituindo o Quality by Testing. Esta metodo

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Πολυκράτης, Απόστολος. "Μελέτη της βιολογικής δράσης και του μηχανισμού μεταγωγής σήματος του αυξητικού παράγοντα HARP (Heparin Affin Regulatory Peptide) σε ενδοθηλιακά κύτταρα". 2005. http://nemertes.lis.upatras.gr/jspui/handle/10889/266.

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Η Heparin affin regulatory peptide (HARP) είναι ένας αυξητικός παράγοντας με μοριακό βάρος 18 kDa, που έχει μεγάλη συγγένεια με την ηπαρίνη. Είναι συντηρημένη μεταξύ διαφόρων ειδών και παρουσιάζει 50% ομολογία με τη Midkine και την RI-HBP. Οι πρωτεΐνες αυτές συγκροτούν μια σχετικά νέα οικογένεια αυξητικών παραγόντων που έχουν συγγένεια με την ηπαρίνη. Η HARP απομονώθηκε για πρώτη φορά από τον εγκέφαλο νεογέννητου βοός ως ένα μόριο που μπορεί να επάγει την προέκταση των νευρικών κυττάρων. Επίσης, εκφράζεται στη μήτρα, στους χόνδρους και στα οστά. Αρκετές αναφορές αποδεικνύουν ότι υπάρχει μεγάλη

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Κίτσου, Παρασκευή. "Η συνδεκάνη-3 διαμεσολαβεί τις βιολογικές δράσεις της HARP". Thesis, 2011. http://nemertes.lis.upatras.gr/jspui/handle/10889/4761.

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Η HARP (Heparin Affin Regulatory Peptide) είναι ένας αυξητικός παράγοντας ο οποίος εμφανίζει πλειάδα βιολογικών δράσεων εμπλεκόμενος στη διαφοροποίηση, τον πολλαπλασιασμό και τη μετανάστευση πολλών τύπων κυττάρων, καθώς και στην αγγειογένεση και την ανάπτυξη όγκων. Η HARP έχει χρονοειδικό και ιστοειδικό πρότυπο έκφρασης, υπερεκφράζεται όμως σε καρκινικές κυτταρικές σειρές, σε ανθρώπινους καρκινικούς όγκους και βρίσκεται σε υψηλή συγκέντρωση στον ορό του αίματος ασθενών με διάφορες μορφές καρκίνου. Η HARP ασκεί τις βιολογικές της δράσεις μετά από δέσμευση στους διαμεμβρανικούς υποδοχείς, SDC3,

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Silva, Marta Isabel de Melo. "Internship Reports and Monograph entitled "Process Analytical Technology: principles and applications"." Master's thesis, 2017. http://hdl.handle.net/10316/83782.

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Relatório de Estágio do Mestrado Integrado em Ciências Farmacêuticas apresentado à Faculdade de Farmácia<br>O presente trabalho foi realizado para defesa do Relatório de Estágio em Farmácia Comunitária, do Relatório de Estágio em Indústria Farmacêutica e da Monografia intitulada “Process Analytical Technology: principles and applications”. Assim, encontra-se dividido em três partes, cada uma destinada à exploração de cada uma das atividades acima mencionadas. O Relatório de Estágio em Farmácia Comunitária assenta numa análise SWOT ao estágio realizado na Farmácia Miranda, onde é feita uma abor

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Abreu, Patrícia da Silva. "Relatórios de Estágio e Monografia intitulada “Óleos essenciais no tratamento da Acne”." Master's thesis, 2021. http://hdl.handle.net/10316/99168.

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Relatório de Estágio do Mestrado Integrado em Ciências Farmacêuticas apresentado à Faculdade de Farmácia<br>Este documento está dividido em três partes. A primeira e segunda parte dizem respeito aos relatórios de estágio referentes aos estágios efetuados, enquanto a terceira parte refere-se à monografia por mim redigida.Uma das etapas finais do ciclo de estudos do Mestrado Integrado em Ciências Farmacêuticas da Faculdade de Farmácia da Universidade de Coimbra (MICF) diz respeito ao estágio curricular, tendo como objetivo principal a consolidação de conhecimentos previamente adquiridos e a sua

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Abreu, Patrícia da Silva. "Relatórios de Estágio e Monografia intitulada “Óleos essenciais no tratamento da Acne”." Master's thesis, 2021. http://hdl.handle.net/10316/99177.

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Relatório de Estágio do Mestrado Integrado em Ciências Farmacêuticas apresentado à Faculdade de Farmácia<br>Este documento está dividido em três partes. A primeira e segunda parte dizem respeito aos relatórios de estágio referentes aos estágios efetuados, enquanto a terceira parte refere-se à monografia por mim redigida.Uma das etapas finais do ciclo de estudos do Mestrado Integrado em Ciências Farmacêuticas da Faculdade de Farmácia da Universidade de Coimbra (MICF) diz respeito ao estágio curricular, tendo como objetivo principal a consolidação de conhecimentos previamente adquiridos e a sua

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Figueiredo, Alina Maria Moreira de. "Medicines registration in Portuguese-speaking African countries, focusing in the following countries: Angola, Cap Verde and Mozambique." Master's thesis, 2015. http://hdl.handle.net/10773/15537.

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Mestrado em Biomedicina Farmacêutica<br>This work aims to present the regulation perspective on the medicines registration in PALOPs – Países Africanos de Língua Oficial Portuguesa (Portuguese‐speaking African countries), their regulatory requirements, constraints and opportunities, focusing on the following countries: Angola, Cape Verde and Mozambique. This thesis has as purpose to deepen and systematize knowledge with regard to the registration procedure of medicines in the selected countries. Regulatory perspective is framed in the context of the health sector and its development an

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Ηλιάδου, Ελένη. "Σχεδιασμός, σύνθεση και μελέτη βιολογικών δράσεων πεπτιδίων της HARP". Thesis, 2010. http://nemertes.lis.upatras.gr/jspui/handle/10889/3209.

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Η Heparin affin regulatory peptide (HARP) είναι ένας αυξητικός παράγοντας με μοριακό βάρος 18 kDa, που έχει μεγάλη συγγένεια με την ηπαρίνη. Είναι συντηρημένη μεταξύ διαφόρων ειδών και παρουσιάζει 50% ομολογία με τη Midkine και την RI-HBP. Οι πρωτεΐνες αυτές συγκροτούν μια σχετικά νέα οικογένεια αυξητικών παραγόντων που έχουν συγγένεια με την ηπαρίνη. Η HARP απομονώθηκε για πρώτη φορά από τον εγκέφαλο νεογέννητου βοός ως ένα μόριο που μπορεί να επάγει την προέκταση των νευρικών κυττάρων. Επίσης, εκφράζεται στη μήτρα, στους χόνδρους και στα οστά. Αρκετές αναφορές αποδεικνύουν ότι υπάρχει μεγάλη

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Διαμαντοπούλου, Ζωή. "Μελέτη του διαφορικού ρόλου των υποδοχέων RPTPβ/ζ και ALK στις βιολογικές δράσεις του αυξητικού παράγοντα HARP και πεπτιδίων του, σε κύτταρα καρκινικών σειρών προστάτη". Thesis, 2010. http://nemertes.lis.upatras.gr/jspui/handle/10889/4206.

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Η HARP (Heparin Affin Regulatory Peptide), γνωστή και ως πλειοτροπίνη, είναι ένας αυξητικός παράγοντας που η έκφρασή του στα ενήλικα άτομα είναι περιορισμένη σε συγκεκριμένους ιστούς. Ωστόσο, έκφραση ή υπερέκφρασή της έχει παρατηρηθεί in vivo σε διάφορους όγκους και στον ορό του αίματος ασθενών με διάφορες μορφές καρκίνου, καθώς και in vitro σε διάφορες καρκινικές κυτταρικές σειρές. Παρόλο που οι in vivo βιολογικές δράσεις της HARP είναι αδιαμφισβήτητες, δεν έχει διασαφηνιστεί ο μηχανισμός με τον οποίο ασκεί τις δράσεις αυτές. Επίσης, υπάρχουν πολλά αντικρουόμενα αποτελέσματα αναφορικά με τι

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Nascimento, Beatriz Alves do. "Relatórios de Estágio e Monografia intitulada “Medicamentos Órfãos – Perspetiva Regulamentar”." Master's thesis, 2021. http://hdl.handle.net/10316/99105.

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Relatório de Estágio do Mestrado Integrado em Ciências Farmacêuticas apresentado à Faculdade de Farmácia<br>Medicamentos órfãos e doenças raras são conceitos que ouvimos com regularidade no nosso quotidiano sem a lucidez dos escassos meios de prevenção, diagnóstico e tratamento que comprometem a qualidade de vida das pessoas portadoras destas doenças, bem como dos familiares que as rodeiam.De modo a fomentar a investigação, produção e comercialização de medicamentos órfãos cada vez mais são criadas políticas pela Agência Europeia do Medicamento (EMA), através do Comité dos Medicamentos Órfãos

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Третьякова, Ольга Олександрівна. "Реінжиніринг діловодства та архівної справи в органах місцевого самоврядування". Магістерська робота, 2020. https://dspace.znu.edu.ua/jspui/handle/12345/5017.

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Третьякова О. О. Реінжиніринг діловодства та архівної справи в органах місцевого самоврядування : кваліфікаційна робота магістра спеціальності 281 "Публічне управління та адміністрування" / наук. керівник О. О. Широбокова. Запоріжжя : ЗНУ, 2020. 134 с.<br>UA : Мета дослідження: вивчення та окреслення особливостей реінжинірингу діловодства та архівної справи в органах місцевого самоврядування (на прикладі архівного управління Запорізької міської ради). Об’єкт дослідження: історія розвитку та еволюції діловодства і архівної справи в системі публічного управління та адміністрування за період іст

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