Dissertations / Theses on the topic 'Regulatory cooperation'
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Pennell, Jennifer Lyn. "State Cooperation on Regulatory Policies for Transboundary Environmental Issues." PDXScholar, 1995. https://pdxscholar.library.pdx.edu/open_access_etds/4937.
Full textMoore, Monica Leigh. "Cultivating cooperation manipulating institutional design features to maximize regulatory efficiency." Tallahassee, Fla. : Florida State University, 2009. http://purl.fcla.edu/fsu/lib/digcoll/undergraduate/honors-theses/244560.
Full textAdvisor: Dr. Christopher Reenock, Florida State University, College of Social Sciences, Dept. of Political Science. Includes bibliographical references.
Götz, Matthias [Verfasser], Wolfgang [Gutachter] Wessels, and Chad [Gutachter] Damro. "In Search of Regulatory Compatibilities. The Constraints on the European Commission’s Strategies in Transatlantic Regulatory Cooperation / Matthias Götz ; Gutachter: Wolfgang Wessels, Chad Damro." Köln : Universitäts- und Stadtbibliothek Köln, 2018. http://d-nb.info/1173321942/34.
Full textZahudi, Zalina Muhamed. "The cooperation among authorities in implementing the regulatory framework for electronic money : Malaysia as a case study." Thesis, Queen Mary, University of London, 2006. http://qmro.qmul.ac.uk/xmlui/handle/123456789/28504.
Full textkalomeni, kevin vivian. "Proliferation of PTAS and EU trade policy: variations in the design of regulatory cooperation mechanisms in CETA." Doctoral thesis, Luiss Guido Carli, 2020. http://hdl.handle.net/11385/204077.
Full textIto, Atsuki. "Culture as Group Dynamics -Collective survival strategy, bases of intragroup cooperation and social hierarchy-." Doctoral thesis, Kyoto University, 2021. http://hdl.handle.net/2433/263731.
Full text新制・課程博士
博士(人間・環境学)
甲第23270号
人博第985号
京都大学大学院人間・環境学研究科共生人間学専攻
(主査)教授 内田 由紀子, 教授 齋木 潤, 教授 月浦 崇
学位規則第4条第1項該当
Doctor of Human and Environmental Studies
Kyoto University
DGAM
Johnson, Russell E. "Uncovering the Motivational Processes Underlying Justice: The Implicit Cognitive, Affective, and Conative Effects of Experiencing (Un)Fairness." University of Akron / OhioLINK, 2006. http://rave.ohiolink.edu/etdc/view?acc_num=akron1150149988.
Full textHellwig, Guilherme Centenaro. "A cooperação regulatória internacional na área financeira : uma análise sob a perspectiva do direito internacional público." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2011. http://hdl.handle.net/10183/32451.
Full textThis study addresses international financial regulatory cooperation in a public international law perspective. It explores the combined efforts of national governments and domestic regulatory authorities to contain international systemic risk and prevent financial crises, as national financial systems became more interdependent and internal regulatory responses – conducted within and limited to national borders – have proved to be insufficient or ineffective. Describing the historical process that culminated with the internationalization of financial activity, this study points out the international consensus that was built, after the global financial crisis, on the need of strengthening regulatory cooperation. It assesses the main characteristics of transgovernmental regulatory networks that have been in the center of international financial regulation in the past three decades, analyzing its distinctive feature of being comprised of substate actors, the consequences of networks informality to international law and its growing concern with legitimacy. Attention is also drawn to the soft law regime and international standard setting process that marks regulatory cooperation in financial matters, in special to the regulatory influence exerted by international financial standards on the Brazilian legal system, the current reform of the international financial architecture after the global crisis and its implications to the future of international regulatory cooperation.
Kopp, Thomas, and Valentin Pfisterer. "Between a rock and a hard place - legal pitfalls of voluntary cooperation of German companies with German and foreign regulatory and law enforcement authorities." Universitätsbibliothek Leipzig, 2016. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-208934.
Full textBuck, Moritz. "Towards the evolution of multicellularity : a computational artificial life approach." Thesis, University of Hertfordshire, 2011. http://hdl.handle.net/2299/6409.
Full textAntal, Jarolím. "Transatlantické hospodárské vzťahy v meniacom sa prostredí svetovej ekonomiky." Doctoral thesis, Vysoká škola ekonomická v Praze, 2009. http://www.nusl.cz/ntk/nusl-191791.
Full textIwai, Tatiana. "Mecanismos formais e informais de regulação na decisão de cooperação: um estudo sobre seus efeitos em dilemas sociais." reponame:Repositório Institucional do FGV, 2005. http://hdl.handle.net/10438/2260.
Full textAcross the years, study fields such as Political Sciences, Organizations and Economy have dedicated to the subject of the role of regulatory mechanisms on the decision behavior of agents. From different perspectives and approaches, each one of those fields have studied the impact of regulatory instruments on the decision of the players for a given action orientation. From the most frequently quoted instruments on the literature to regulate the action of the agents, we can point out formal and informal regulatory mechanisms. An intense debate over the studies dedicated to the subject has taken place, discussing the efficiency of each of those mechanisms on the player s decision. Given the relevance of such debate, the present study aims to compare the effectiveness of formal and informal regulatory mechanisms on one’s decision of cooperating to social dilemmas. Such dilemmas are situations on which a person, searching for one’s own interests, takes the group to worse results than those that would have been reached if there were cooperation among the group. To reach the goal of this study, we performed an experiment with undergraduate students from EAESP-FGV to test in an experimental environment the behavior of the agents under the pressure of two regulatory mechanisms. The results of this experiment showed that the informal regulatory mechanisms have a greater influence on the player s decision to cooperate and the presence of such mechanisms reduces the necessity of using a formal regulatory mechanism to ensure the cooperation from members of a group.
Ao longo dos anos, campos de estudos como os de ciência política, organizações e economia vêm se debruçando sobre a questão do papel de mecanismos regulativos no comportamento decisório do indivíduo. A partir de óticas e abordagens diferentes, cada um desses campos vem estudando o impacto de instrumentos de regulação na conformação dos atores para determinada orientação de ação. Dos instrumentos mais citados na literatura para regular a ação do ator, podemos apontar os mecanismos formais e informais de regulação. Um intenso debate entre os trabalhos dedicados ao assunto vem sendo travado, discutindo a eficiência de cada um deles na conformação do ator. Dada a relevância desse debate, o presente trabalho teve como objetivo comparar a efetividade de mecanismos formais e informais de regulação na decisão de cooperação do indivíduo em dilemas sociais, que são situações onde cada indivíduo ao buscar seu interesse próprio, leva a coletividade a resultados piores do que aqueles que seriam atingidos, caso houvesse cooperação do grupo. Para alcançarmos o objetivo do trabalho, realizou-se um experimento com alunos da graduação da EAESP-FGV para testar em ambiente laboratorial o comportamento dos agentes sob a pressão dos dois mecanismos de regulação. Os resultados do experimento mostraram que mecanismos informais de regulação têm maior influência na decisão de cooperação do ator, assim como sua presença diminui a necessidade do uso de um mecanismo formal de regulação para assegurar a cooperação dos membros de um grupo.
Rachman, Nora Matilde. "Caminhos da cooperação regulatória no mercado de capitais." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/101/101131/tde-12112013-105022/.
Full textThe recent global financial crisis brought to the center of international discussion the debate concerning the regulation of capital markets, including its many variances, as a factor responsible for the crisis. The focus of this work is on the role of international cooperation in regard to regulation, with specific attention given to particular aspects such as the existence of incentives, preferences, ideas, and institutions inherent to cooperation between states. As such, this dissertation will provide a systematic analysis of regulatory initiatives taken by four countries between the years 2007 and 2011. The goal was to verify the existence of patterns, specific models, as well as pathways to cooperation in the regulation of capital markets. The principle results suggest an effective domestic scrutiny of international recommendations driven mostly by the outbreak of the global financial crisis, and as a result a broader concept of what is understood as regulatory cooperation. Besides new measures of supervision and enforcement, the work verified the emergence of regulatory initiatives, with both common elements and formats that take into consideration the interaction of political determinants and economic consequences arising from this momentum.
McKee, Kimberly. "Reconfiguring housing governance in Glasgow post-stock transfer regulatory and liberatory possibilities /." Thesis, Move to record for print version. Connect to e-thesis record to view abstract, 2007. http://theses.gla.ac.uk/44/.
Full textPh.D. thesis submitted to the Department of Urban Studies, Faculty of Law, Business and Social Sciences, University of Glasgow, 2007. Includes bibliographical references.
Нижник, З. В. "Стан та перспективи співробітництва територіальних громад." Thesis, Одеський національний економічний університет, 2020. http://dspace.oneu.edu.ua/jspui/handle/123456789/12641.
Full textThe work considers the theoretical principles of functioning of cooperation of local communities: cooperation such as essence of the concept, benefits of establishing cooperation, main tasks, possible forms of cooperation and procedure for organizing cooperation of territorial communities. The regulatory and legal support has been analyzed, the current state of development and cooperation of territorial communities has been found out, foreign experience of cooperation of territorial communities has been characterized. The problems of introduction of the mechanism of cooperation of local communities has been analyzed, the potential for development of management tools to support cooperation of local communities have been considered and offers on overcoming of proposals to improve the quality of administrative services in the development of cooperation of territorial communities are given.
Hene, Boniswa Debbie. "Cooperative government in South Africa : examining enforcement mechanisms for municipalities to comply with South Africa’s water regulatory framework." Thesis, University of the Western Cape, 2015. http://hdl.handle.net/11394/5119.
Full textThere is overwhelming evidence that South Africa’s rivers are heavily polluted, a situation which is attributable to a large degree to poorly functioning and inefficiently managed waste water treatment works in municipalities. The evidence suggests, furthermore, that municipalities often do not comply with their constitutional obligation to provide water services in a sustainable manner and promote a safe and healthy environment. Such non-compliance infringes on people's constitutionally guaranteed rights to a pollution-free environment and equitable access to sufficient and safe water. The problem is that municipalities are not properly managing the waste water treatment works (WWTWs) and not regulating industrial discharge into these works in accordance with the prescribed national norms and standards. The National Water Act 36 of 1998 and other related Acts provide for legal and informal enforcement mechanisms that criminalise acts of pollution. However, none of them have been effective in enforcing municipal compliance with the national norms and standards of effluent management. There are two main reasons for this. First, the constitutional structure does not allow the Minister responsible for water management to exercise direct supervision of the municipalities despite the functional relationship the Department of Water and Sanitation has with municipalities in respect of water. Secondly, the Constitution (1996) instructs the spheres of government to avoid legal processes and cooperate with one another by intervening to execute the function if the sphere responsible for the function lacks capacity. This thesis explores the possible use of two statutory instruments of cooperative government and intergovernmental relations as strategies to complement and support the conventional enforcement measures in the water sector: the establishment of water intergovernmental forums; and the use of implementation protocols to supervise municipalities that chronically lack capacity as a way of providing targeted support and monitoring to facilitate an effective compliance and enforcement regime in the water sector.
VIOLA, ANDREA. "CREDITO COOPERATIVO: STRUTTURA ORGANIZZATIVA, PROSSIMITà ED ACCESSO AL CREDITO." Doctoral thesis, Università Cattolica del Sacro Cuore, 2022. http://hdl.handle.net/10280/119851.
Full textThe thesis aims to study Italian cooperative credit and is divided into two chapters. The first one empirically investigates the efficiency of the network organizational model by studying economies of scale, economies of scope and market power, in light of the reform introducing the integrated organizational structure in 2018. For 452 cooperative banks (and a control group of 223 commercial banks) over the period 2006-2018, the empirical results show that cooperative banks experience economies of scale and scope, but experience consistent diseconomies of scale and economies of scope on the revenue side. Increases in diversification and size do not positively impact revenues. Cooperative banks have greater market power than commercial banks. The second chapter empirically investigates the persistence of the advantages of relationship lending for Italian firms, measured as easier access to bank credit due to the proximity of (at least) one cooperative bank branch. For 348,019 firms (1,135,125 observations) over the period 2012-2019, the empirical results show that firms located near cooperative bank branches have more access to bank debt and resort less to informal finance (trade credit, member loans). These effects are even stronger when firms are only located in close proximity to cooperative bank branches.
Fischer, Stefan W. "An explorative study of performance management in the German cooperative banking sector in response to regulatory and market forces." Thesis, University of Strathclyde, 2014. http://oleg.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=24651.
Full textSu, Qi [Verfasser]. "Interaction between glucocorticoids and Toll-like receptor 2: regulatory and cooperative effects of glucocorticoids on cutaneous cells / Qi Su." Berlin : Freie Universität Berlin, 2017. http://d-nb.info/114292081X/34.
Full textVlachou, Charikleia. "La coopération entre les autorités de régulation en Europe (communications électroniques, énergie)." Thesis, Paris 2, 2014. http://www.theses.fr/2014PA020055/document.
Full textThe cooperation among regulatory authorities in the field of electronic communications and energy takes place against the background of the transformation of the european administration in the last two decades. Its institutional design bears the mark of the europeanisation of regulators through the harmonisation brought about by EU law and the diffusion of best practices. The cooperation among regulatory authorities is formalised on the basis of a primary law that is vague. It is also marked by ambiguity with regard to the delegation of pouvoirs on a European level. In the sectors of energy and electronic communications, it reflects the « hybrisation » of two models of governance, European agencies and networks, giving birth to a powerful « network agency » in the field of energy-the ACER- and a weak « agenciarised network » in the field of electronic communications- the BEREC. The control of the acts of these two organisms in a « Union of law » is ensured by the Cour of justice of the European Union which is, however, difficult to accessfor individuals. In this context, the European Ombudsman demonstrates a real potential as a complementary forum of control. Against a priori hypotheses with respect to the democratic deficit of the European Union, the European Parliament effectively ensures the democratic control of ACER and BEREC. Even if its means of political control are largelyinformal and should be better defined, the control it exercices in the context of the budgetary discharge procedure is capable of transforming the institutional design of the above mentioned organisms
Soro, Russell Olivier. "El contrato normativo : análisis de una categoría." Thesis, Bordeaux 4, 2013. http://www.theses.fr/2013BOR40017.
Full textHow far are now individuals free to create the most appropriate contractual tool to achieve the satisfaction of their needs and interests? What they have in common figures as diverse as a joint-venture agreement, a franchise agreement or a marriage contract? Is the old general theory of contract adapted to the contractual practice of the XXI century? A deep study of the normative contract in this book provides answers to these and to many other momentous matters of Private Law of Contract. Reconstructed from the detailed analysis of the theory and legal practice, the notion of normative contract as an agreement of cooperative nature could constitute the bridge to a new and inspiring way of conceiving the contract. Not surprisingly, as shown by its main practical manifestations, the contract is often more than just an instrument to organize an exchange of goods and services, a powerful regulatory tool of reality and human behavior. To put it briefly, if on the one hand in this essay the author seeks find a remedy for a situation of great uncertainty regarding the so-called normative contract, in the other hand he also invites the legal community to reflect calmly on the role played by contract in present society.Keywords: Normative contract, Normenvertrag, Alfred HUECK, genesis, concept, pactum de modo contrahendo, contrat-cadre, framework agreements, distribution, collective agreement, financial transactions, joint venture, marriage contract, codes of conduct, Spanish private law, French private law, contractual clause, cooperative agreement, intuitus personae, no-obligational and obligational content of the contract, union of contracts, regulatory function of contract, general contract theory, theory of legal regulation, Hans KELSEN , freedom of contract
Kinuthia, Wanyee. "“Accumulation by Dispossession” by the Global Extractive Industry: The Case of Canada." Thèse, Université d'Ottawa / University of Ottawa, 2013. http://hdl.handle.net/10393/30170.
Full textBARZANTI, Fabrizio. "Media pluralism and the European audiovisual space : the role and cooperation of independent regulatory authorities." Doctoral thesis, 2015. http://hdl.handle.net/1814/40806.
Full textExamining Board: Professor Bruno de Witte (European University Institute, Supervisor); Professor Loïc Azoulai (European University Institute); Doctor Rachael Craufurd Smith (University of Edinburgh); Professor Roberto Mastroianni (Università di Napoli).
This thesis explores the legal and institutional settings that contribute to the creation of general preconditions for the freedom of expression and, primarily, genuine pluralism to prosper throughout the European audiovisual media space. Taking into account the intense legislative and judicial activity on audiovisual media matters in the European Union (EU) and bearing in mind the developments brought about by new digital communications and technological convergence, the analysis focuses on the institutional forms and modes of governance for the media that are apt to foster an effective and consistent supranational approach to the fundamental objective of media pluralism and the values it involves, considering notably the role and functioning of Independent Administrative Authorities (IAAs) for the media. To this end, the three Parts into which the Thesis is divided deal with, respectively: the notion of media pluralism and its employment in EU law, highlighting the limits of classical hard-law based approaches (Part I); an examination of the institutional features as well as the operation of three national IAAs for the media – namely, the French Conseil Supérieur de l'Audiovisuel (CSA), the UK Office of Communications (Ofcom) and the Italian Autorità per le Garanzie nelle Comunicazioni (AGCom) – selected as case studies to illustrate the role of these bodies in securing media pluralism (Part II); the investigation of EU action in setting the necessary institutional preconditions and some specific related requirements to guarantee attainment of this objective, also looking in some detail at the legislative developments that have occurred in comparable sectors, such as data protection legislation, equality law and electronic communication regulation, before considering the arrangements in place at the supranational level, as well as the incipient ones in the governance of audiovisual media (Part III).
Chen, Yi-ting, and 陳奕廷. "Non-tariff Barrier to Trade and Development and Challenge of Regulatory Cooperation: Lessons from Mega-regionalism." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/8u389n.
Full text國立清華大學
科技法律研究所
106
After analyzing the Regulatory chapter in mega-regional trade agreements, this paper finds that parties involve in mega-regional trade agreements are still conservative about regulatory cooperation, given that regulatory cooperation is an effective tool eliminating regulatory barrier to trade. Many mega-regional agreements already incorporated regulatory cooperation in to their content and aiming high-level cooperation. However, the parties in mega-regional agreements seems outweigh regulatory sovereignty than the benefit of regulatory cooperation, and do not allow other parties and interest group from other parties influence their process of policy making through regulatory cooperation. Therefore, the majority of mandatory regulatory cooperation in mega-regional agreements remains low-level, and high-level regulatory cooperation becomes optional. This paper also review Taiwan’s regulatory cooperation mechanism in FTAs, and try to make suggestions relating the usage and phenomena of regulatory cooperation for Taiwan.
Davidson, Nigel Joseph. "The lion that didn't roar : can regulatory theory save the Kimberley process?" Thesis, 2011. http://hdl.handle.net/1885/151474.
Full textLai, Wei-Ting, and 賴瑋婷. "Studies of the regulatory mechanism of the Low-Molecular-Weight Bacteriocin carocin gene through c-di-GMP and CRP cooperation in Pectobacterium carotovorum subsp. carotovorum." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/7f2zd6.
Full text國立中興大學
化學系所
101
Pectobacterium carotovorum subsp. carotovorum is a phytopathogenic enterobacterium. Some of Pectobacterium carotovorum subsp. carotovorum strains produced low-molecular-weight-bacteriocin by ultraviolet induction. But litte is known about the signal transduction pathway of low-molecular-weight- bacteriocin carocin gene. The previous studies from our lab has shown that crp-defective mutant and dgc -defective mutant could not express carocin gene respectively. In this study, we want to known that how is the regulatory mechanism of carocin gene throgh cyclic dimeric guanosine monophosphate (c-di-GMP) and cAMP receptor protein(CRP) cooperation? Here, we analyzed the carocin gene upstream sequence by the DNASIS MAX program and this sequence analysis indicated that the carocin gene upstream region contains two putative CRP binding sites. Thus, we designed two 30 bp DNA fragments as biotinylated probes and each probe contains the putative CRP binding site respectively. We thus used the biotinylated probe pull down assay and prepared the CRP polyclonal antibody for western blotting. As a result, in our experiments, CRP binds to two putative CRP sites called CIE-1(carocin induced element-1) and CIE-2(carocin induced element-2). CIE-1 located at positions -112~-117 bp relative to the translation start site, while CIE-2 located at positions -17~-22 bp. Without ultraviolet induction, CRP binds CIE-1 or CIE-2 dominantly in the biotinylated probe pull down assay. With ultraviolet induction, CRP binds to CIE-1 and CIE-2. In addition, in the absence of c-di-GMP, the level of CRP binds to CIE-1 and CIE-2 obviously decreased. Based on the data presented in this study, we think maybe c-di-GMP is a novel effecter for CRP allosteric transition and thus the cooperation of c-di-GMP and CRP regulates the carocin gene. We proposed that ultraviolet induction may cause increasing the level of c-di-GMP concetration and the role of c-di-GMP is to convert CRP from a repressor to an activator. In conclusion, our results attempted to model a signal transduction pathway of the carocin gene expression in response to the ultraviolet induction. In particular, we implicated the roles of the c-di-GMP and CRP cooperation in the carocin gene.
Adcock, Fleur. "The United Nations special procedures and Indigenous peoples : a regulatory analysis." Phd thesis, 2014. http://hdl.handle.net/1885/155949.
Full textMaluleka, Khulumane John. "Transport economic regulatory intervention in the transport infrastructure : a public-private partnership exploratory study." Diss., 2008. http://hdl.handle.net/10500/1926.
Full textTransport Logistics & Tourism
D. Comm.
Gintzburger, Anne-Sophie H. M. "The sources in variation in the application of Shari'a-compliant finance contracts : a comparative analysis of Shari'a scholars, Shari'a board roles, and regulatory variations in Malaysia and the Gulf Cooperation Council (GCC) states." Master's thesis, 2009. http://hdl.handle.net/1885/151670.
Full textAmorim, Rute Filipa Oliveira. "TTIP: que oportunidades e desafios para a União Europeia?: o caso da cooperação regulatória." Master's thesis, 2017. http://hdl.handle.net/1822/49518.
Full textA presente dissertação versa sobre o Transatlantic Trade and Investment Partnership (TTIP), acordo proposto entre a União Europeia e os EUA. O acordo foi objeto de um conjunto de negociações com o intuito de criar uma zona de comércio livre no Atlântico. O seu principal objetivo é reduzir as barreiras tarifárias e regulatórias, nas mais diversas áreas de ligação comercial e de investimento entre a União Europeia e os Estados Unidos da América. Pretende-se com ele criar uma relação estratégica e dinâmica, capaz de responder a desafios regionais e globais. A presente dissertação tem como objetivo analisar os impactos económicos e comerciais gerados pelo acordo na União Europeia, e no mercado único europeu, como também nos Países-Membros. A dissertação foca em particular a cooperação regulatória, que passa pela harmonização ou reconhecimento mútuo dos princípios que regem as certificações de bens e serviços. Metodologicamente, esta dissertação tem um carácter exploratório e analítico, pois a pesquisa tem como principal objetivo a obtenção de conhecimento. A dissertação vai mais além da descrição do acordo, tentando analisar as motivações, efeitos e consequências da sua implementação bem como, sintetiza algumas recomendações para que possa vir a ser bemsucedido no âmbito da cooperação regulatória.
The present dissertation analyses Transatlantic Trade and Investment Partnership (TTIP), negotiated between the European Union and the United States of America. The agreement aims to create a free trade zone in the Atlantic. Its main objective is to reduce tariff non-tariff barriers in trade and investment between the European Union and the United States. It is intended to create a strategic and dynamic relation, capable to answer to regional and global challenges. This dissertation has as goal to analyze the economic and commercial impacts generated by the agreement upon the European Union, and the European single market, as well as on its members.states. The dissertation focus on the regulatory cooperation, provisions of the agreement, that comprises harmonization or mutual recognition of the principles underlying the certification of commercialized goods and services. Methodologically, this dissertation has an exploratory and analytical character, as the researchs has as its main objective to acquire new knowledge on the topic. The dissertation goes beyond the description of the agreement, trying to analyze the motivations, effect and consequences of its implementation, as well as it systematizes some recommendations that may help to the sucess of the agreement in the área of regulatory cooperation.
Gomes, Antonio. "Computational approaches to deciphering regulatory circuits in mycobacterium tuberculosis from chip-seq data, and developing theoretical strategies to combat drug-resistant infections." Thesis, 2013. https://hdl.handle.net/2144/14240.
Full textJankowski, Aleksander. "Modeling transcription factor complex binding to eukaryotic genomes." Doctoral thesis, 2014.
Find full textWiązanie czynników transkrypcyjnych do specyficznych motywów w elementach regulatorowych znajdujących się w genomach organizmów eukariotycznych jest zazwyczaj badane dla każdego z czynników oddzielnie, bez uwzględniania wpływu pozostałych. Jednakże w celu pełnego poznania mechanizmów regulacji transkrypcji należy rozstrzygnąć, które czynniki transkrypcyjne wiążą się kooperatywnie do DNA jako dimery lub kompleksy wyższego rzędu, a także poznać dokładną naturę tych oddziaływań. Do tej pory znana jest tylko niewielka liczba takich kooperatywnych kompleksów.W tej pracy przedstawiamy wielkoskalową i specyficzną dla poszczególnych typów komórek metodę przewidywania dimeryzacji czynników transkrypcyjnych na DNA. Stosujemy ją do danych o nadwrażliwości na DNazę I, reprezentując możliwe kompleksów czynników transkrypcyjnych przez odpowiednie kompleksy ich motywów. Następnie analizujemy występowanie tych kompleksów w regionach otwartej chromatyny specyficznych dla poszczególnych typów komórek. W ten sposób przewidzieliśmy 603 istotnie nadreprezentowanych dimerów czynników transkrypcyjnych, spośród których zdecydowana większość nie była wcześniej znana. Nasze przewidywania obejmują 69% (20 z 29) zbioru znanych dimerów, który zebraliśmy z istniejącej literatury biochemicznej. Przewidywania były również niezależnie potwierdzone przez ewolucyjną konserwację, a także przez ilościową zmienność w profilach cięcia DNazą I.Co istotne, zarówno znane, jak i przewidywane dimery czynników transkrypcyjnych niemal zawsze były zwarte i sztywnie rozmieszczone. Sugeruje to, że dimeryzacja czynników transkrypcyjnych zachodzi w bezpośredniej ich bliskości, co narzuca ścisłe ograniczenia w strukturze kompleksu związanego z DNA. Stosując naszą metodę do danych ChIP-seq, ustaliliśmy ogólną zasadę regulującą strukturę kompleksów złożonych z dwóch czynników transkrypcyjnych i DNA, mianowicie, że ich elastyczność jest skorelowana z odstępem między motywami tych czynników na sekwencji DNA, prawdopodobnie będąc jego konsekwencją.Aby umożliwić upowszechnienie naszej metody, opracowaliśmy program TACO, który przyjmuje jako wejście dowolny zbiór genomowych elementów regulatorowych i przewiduje dimery czynników transkrypcyjnych specyficzne dla poszczególnych typów komórek w oparciu o nadreprezentację kompleksów motywów. Jest to pierwsze narzędzie tego typu, które obsługuje kompleksy złożone z nachodzących na siebie motywów. Takie kompleksy są cechą wielu znanych dimerów czynników transkrypcyjnych. Na podstawie porównania ze wspomnianym zbiorem 29 znanych dimerów, stwierdziliśmy że nasza metoda prześciga istniejące, iTFs i SpaMo.Pod koniec pracy przedstawiamy program MOCCA, będący nowatorską obliczeniową metodą identyfikacji poszczególnych miejsc wiązania czynników transkrypcyjnych, na postawie informacji o sekwencji genomu oraz danych eksperymentalnych specyficznych dla typów komórek, takich jak dane DNase-seq. Łączymy zalety dwóch poprzednich podejść, CENTIPEDE i Wellingtona, zachowując przy tym rozsądnie ograniczoną liczbę wolnych parametrów w modelu. Nasza metoda jest wyjątkowa przez to, że dopuszcza by pojedynczy czynnik transkrypcyjny miał wiele różnych stanów wiązania z DNA, różniących się profilami cięcia DNazą I oraz ogólną liczbą tych cięć.
Fonseca, Ana Rita Vicente da. "Compliance Fiscal." Master's thesis, 2021. http://hdl.handle.net/10316/97483.
Full textTendo em atenção que atualmente é indiscutível que o Estado deve intervir na economia, de modo a assegurar a livre concorrência e a corrigir as falhas no mercado, nesta dissertação serão abordadas as deficiências da política fiscal adotada e a necessidade de mudanças no sistema tributário.Com o objetivo do aumento do índice de compliance, será analisada a insuficiência da atuação exclusivamente punitiva do Estado em caso de não cumprimento das obrigações tributárias (noncompliance), isto porque são vários os fatores que influenciam o comportamento dos contribuintes para além da componente económica, sendo necessária uma política de incentivo ao comportamento em conformidade com as regras tributárias (compliancefiscal). Neste sentido, o modelo de regulação fiscal cooperativa defende uma relação de maior proximidade entre a administração tributária e o contribuinte, existindo entre ambos uma relação de cooperação e de confiança, que poderá resultar num aumento da conformidade fiscal.É de destacar, com vista a um resultado positivo das administrações tributárias, as orientações e sugestões propostas pela Organização para a Cooperação e Desenvolvimento Económico (OCDE), que defendem a prática de elementos de boa governança corporativa, como a transparência e a informação, promovendo um clima de confiança e de justiça fiscal.A boa governança corporativa assume especial importância nas empresas, sendo essencial para a integridade das mesmas e consequentemente para a estabilidade económica e financeira. Desta forma, deveres como a transparência e accountability devem fazer parte da gestão empresarial, existindo assim uma maior dificuldade de praticar evasão ou sonegação fiscal, e consequentemente uma maior conformidade fiscal.Por fim, o compliance é fundamental para tornar o planeamento tributário eficiente e assegurar que o mesmo está em conformidade com a lei tributária, garantindo assim que os agentes económicos assumem uma postura em conformidade com a lei.Palavras-Chave: Estado Regulador; Política Fiscal;Compliance Fiscal; Regulação Fiscal Cooperativa;Boa Governança Corporativa
Considering that it is currently indisputable that the State must intervene in the economy, in order to ensure free competition and correct market failures, this dissertation will address the deficiencies of the fiscal policy adopted and the need for changes in the tax system.With the objective of increasing the compliance index, the insufficiency of the exclusively punitive action of the State in case of non-compliance with tax obligations will be analysed, because there are several factors that influence the behaviour of taxpayers besides the economic component, being necessary a policy of incentive to behaviour in conformity with the tax rules (tax compliance). In this sense, the model of cooperative tax regulation advocates a relationship of greater proximity between the tax administration and the taxpayer, with a relationship of cooperation and trust between the two, which may result in an increase in tax compliance.It is worth mentioning, with a view to a positive outcome for tax administrations, the guidelines and suggestions proposed by the Organization for Economic Cooperation and Development (OECD), which advocate the practice of elements of good corporate governance, such as transparency and information, promoting a climate of trust and tax justice.Good corporate governance is of particular importance in companies, being essential to their integrity and consequently to economic and financial stability. In this way, duties such as transparency and accountability must be part of the corporate management, thus making it more difficult to practice tax evasion or tax avoidance, and consequently a greater tax compliance.Finally, compliance is fundamental to make tax planning efficient and ensure that it is in accordance with the tax law, thus ensuring that economic agents assume an attitude in accordance with the law.Keywords: Regulatory State; Tax Policy; Tax Compliance; Cooperative Tax Regulation; Good Corporate Governance
Рудий, А. О. "Способи мінімізації кредитного ризику банку (на прикладі банку Південний)." Thesis, 2018. http://dspace.oneu.edu.ua/jspui/handle/123456789/7852.
Full textThe analysis of the credit market of Ukraine, Characteristics of the financial state and results of the banking institution, The practice of minimizing credit risk in the joint-stock bank "Pivdennyi", Foreign experience in minimizing credit risk is analyzed. Practical aspects of organization of the system of protection against credit risk in Joint-Stock Bank "Pivdennyi" are offered.