Log in

Relevant bibliographies by topics / Regulatory lymphocytes T cells / Journal articles

To see the other types of publications on this topic, follow the link: Regulatory lymphocytes T cells.

Journal articles on the topic 'Regulatory lymphocytes T cells'

Author: Grafiati

Published: 4 June 2021

Last updated: 2 February 2022

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'Regulatory lymphocytes T cells.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Savchenko, Andrey, Aleksandr Borisov, Igor Kudryavtsev, and Anton Moshev. "RELATIONSHIP OF THE T-REGULATORY CELLS NUMBER WITH THE CYTOTOXIC T-LYMPHOCYTES AND NKT-CELLS LEVELS IN PATIENTS WITH RENAL CANCER." Problems in oncology 63, no. 1 (2017): 104–9. http://dx.doi.org/10.37469/0507-3758-2017-63-1-104-109.

Full text

Abstract:

The aim of the study was to investigate the features of the relation to the number and the phenotype of the cytotoxic T-lymphocytes and NKT-cell from regulatory T-cells content in the blood by patients with renal cell carcinoma. The study included patients with renal cell carcinoma (T3N0M0, clear cell type) at the age of 40-55 years before surgery. Lymphocyte immunophenotyping was performed by flow cytometry. It is found that in the peripheral blood of the patients with renal cell carcinoma accompanied by increased number of T-regulatory cells observed decrease content of the cytotoxic T-lymph

APA, Harvard, Vancouver, ISO, and other styles

2

Kanakry, Christopher G., Allan D. Hess, Christopher D. Gocke, et al. "Early lymphocyte recovery after intensive timed sequential chemotherapy for acute myelogenous leukemia: peripheral oligoclonal expansion of regulatory T cells." Blood 117, no. 2 (2011): 608–17. http://dx.doi.org/10.1182/blood-2010-04-277939.

Full text

Abstract:

AbstractFew published studies characterize early lymphocyte recovery after intensive chemotherapy for acute myelogenous leukemia (AML). To test the hypothesis that lymphocyte recovery mirrors ontogeny, we characterized early lymphocyte recovery in 20 consecutive patients undergoing induction timed sequential chemotherapy for newly diagnosed AML. Recovering T lymphocytes were predominantly CD4+ and included a greatly expanded population of CD3+CD4+CD25+Foxp3+ T cells. Recovering CD3+CD4+CD25+Foxp3+ T cells were phenotypically activated regulatory T cells and showed suppressive activity on cytok

APA, Harvard, Vancouver, ISO, and other styles

3

Huber, Sally A. "γδ T lymphocytes kill T regulatory cells through CD1d". Immunology 131, № 2 (2010): 202–9. http://dx.doi.org/10.1111/j.1365-2567.2010.03292.x.

Full text

APA, Harvard, Vancouver, ISO, and other styles

4

Reyes García, María Guadalupe, and Fernando García Tamayo. "The Importance of the Nurse Cells and Regulatory Cells in the Control of T Lymphocyte Responses." BioMed Research International 2013 (2013): 1–15. http://dx.doi.org/10.1155/2013/352414.

Full text

Abstract:

T lymphocytes from the immune system are bone marrow-derived cells whose development and activities are carefully supervised by two sets of accessory cells. In the thymus, the immature young T lymphocytes are engulfed by epithelial “nurse cells” and retained in vacuoles, where most of them (95%) are negatively selected and removed when they have an incomplete development or express high affinity autoreactive receptors. The mature T lymphocytes that survive to this selection process leave the thymus and are controlled in the periphery by another subpopulation of accessory cells called “regulato

APA, Harvard, Vancouver, ISO, and other styles

5

Vigouroux, Stephane, Eric Yvon, Ettore Biagi, and Malcolm K. Brenner. "Antigen-induced regulatory T cells." Blood 104, no. 1 (2004): 26–33. http://dx.doi.org/10.1182/blood-2004-01-0182.

Full text

Abstract:

Abstract Regulatory T cells participate in immunologic homeostasis by active suppression of inappropriate immune responses. Regulatory T lymphocytes expressing CD4 and CD25 antigens and naturally present in the peripheral blood were the first to be phenotypically characterized. However, their small number and antigen nonspecific suppression has prompted efforts to identify and dissect antigen-specific regulatory T cells. In this review we discuss how antigen-specific regulatory T cells can be identified, the cellular and molecular mechanisms underlying their induction and activity, and the cha

APA, Harvard, Vancouver, ISO, and other styles

6

Avdeeva, A. S., Yu P. Rubtsov, T. V. Popkova, D. T. Dyikanov, A. P. Aleksankin, and E. L. Nasonov. "FEATURES OF THE PHENOTYPE OF REGULATORY T CELLS IN EARLY AND ADVANCED RHEUMATOID ARTHRITIS." Rheumatology Science and Practice 56, no. 4 (2018): 423–28. http://dx.doi.org/10.14412/1995-4484-2018-423-428.

Full text

Abstract:

Objective: to analyze the levels of CD3+, CD3+CD4+, CD3+CD8+, and CD3-CD56+ T lymphocytes, FoxP3+ regulatory T cells (Treg), and CD19+ B lymphocytes in patients with early and advanced rheumatoid arthritis (RA). Subjects and methods. The investigation enrolled 45 patients previously untreated with methotrexate (MTX-naive) who had early RA and 15 patients who had advanced RA. Immunofluorescence staining and multicolor flow cytometry assays were used to estimate the percentage and absolute (abs) counts of CD3+, CD3+CD4+, CD3+CD8+, CD3-CD16+CD56+, CD19+, Treg(FoxP3+CD25+; surface CD152+; intracel

APA, Harvard, Vancouver, ISO, and other styles

7

Pochtar, Evgeniy Vladimirovich, S. A. Lugovskaya, E. V. Naumova, E. A. Dmitrieva, A. I. Kostin, and V. V. Dolgov. "Specific features of T- and NK-cellular immunity in chronic lymphocytic leukemia." Russian Clinical Laboratory Diagnostics 66, no. 6 (2021): 345–52. http://dx.doi.org/10.51620/0869-2084-2021-66-6-345-352.

Full text

Abstract:

Profound immunological dysfunction is the key factor determining the development of infectious complications in chronic lymphocytic leukemia (CLL). The aim of this work is to assess the features of the subpopulation composition of T-lymphocytes (T-helpers (Th), cytotoxic T-lymphocytes (Tcyt), T regulatory cells (Treg), T-NK cells, naive Th, Th-memory, activated T-lymphocytes, TCRγδ cells) and NK cells in peripheral blood of patients with newly diagnosed chronic lymphocytic leukemia (CLL) and receiving ibrutinib therapy. Hematological and immunophenotypic studies have been performed in 30 patie

APA, Harvard, Vancouver, ISO, and other styles

8

Chen, Lin-Ying, Julia Y. S. Tsang, Yun-Bi Ni, et al. "Lymphocyte subsets contribute to the degree of lobulitis and ductitis in sclerosing lymphocytic lobulitis of the breast." Journal of Clinical Pathology 69, no. 6 (2015): 527–32. http://dx.doi.org/10.1136/jclinpath-2015-203334.

Full text

Abstract:

AimsSclerosing lymphocytic lobulitis (SLL) of the breast is characterised by lymphocytic lobulitis, ductitis, vasculitis and dense keloidal fibrosis with epithelioid fibroblasts. However, the subsets of the infiltrating lymphocytes and their contribution to disease progression have not been fully explored.MethodsCD20, CD3, CD4, CD8 and regulatory T (Treg) lymphocytes were evaluated in the epithelial and vascular areas in SLL. The relationship between the lymphocyte subset in different regions and the degree of inflammation was analysed.ResultsLymphocytic infiltration was mainly located in peri

APA, Harvard, Vancouver, ISO, and other styles

9

Romuk, Ewa, Bronisława Skrzep-Poloczek, Celina Wojciechowska, Wojciech Jacheć, Bogdan Mazur, and Ewa Birkner. "Evaluation of CD25+CD4+ Regulatory T-Lymphocyte Subpopulations in Coronary Artery Diseases Patients." ISRN Biomarkers 2014 (March 4, 2014): 1–5. http://dx.doi.org/10.1155/2014/562587.

Full text

Abstract:

Background. The development of atherosclerosis may be associated with a deficiency in the regulatory T-cells, which should serve a protective function and inhibit the accumulation of lymphocytes and macrophages. The aim of this study was the analysis of the T-lymphocyte subpopulations, particularly CD4+CD25+ regulatory T-cells in patients with different form of coronary artery disease. Materials and Methods. In the study 30 patients with stable coronary heart disease and 30 patients with unstable coronary heart disease take part. Lymphocytes subpopulations were measured with flow cytometry tec

APA, Harvard, Vancouver, ISO, and other styles

10

Torgashina, A. V., and S. К. Solovyev. "Specific features of regulatory T cells in patients with systemic lupus erythematosus." Modern Rheumatology Journal 12, no. 4 (2018): 9–15. http://dx.doi.org/10.14412/1996-7012-2018-4-9-15.

Full text

Abstract:

Regulatory T cells (Tregs) is a CD4+ lymphocyte subpopulation that maintains autotolerance by suppressing the activity of autoreactive lymphocytes. There is a hypothesis that functional defects or a smaller number of Tregs underlie the pathogenesis of a number of autoimmune diseases. The paper considers the main features of the phenotype of Tregs. It discusses the number of Tregs in both peripheral blood and affected organs in systemic lupus erythematosus, as well as the time course of changes in the level and functional abilities of different subpopulations of Tregs during immunosuppressive t

APA, Harvard, Vancouver, ISO, and other styles

11

Grossman, William J., James W. Verbsky, Benjamin L. Tollefsen, Claudia Kemper, John P. Atkinson, and Timothy J. Ley. "Differential expression of granzymes A and B in human cytotoxic lymphocyte subsets and T regulatory cells." Blood 104, no. 9 (2004): 2840–48. http://dx.doi.org/10.1182/blood-2004-03-0859.

Full text

Abstract:

Abstract Cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells use the perforin/granzyme pathway as a major mechanism to kill pathogen-containing cells and tumor cells.1,2 Dysregulation of this pathway results in several human diseases, such as hemophagocytic lymphohistiocytosis. Here we characterize the single-cell expression pattern of granzymes A and B in human lymphocytes using a flow cytometry-based assay. We demonstrate that most circulating CD56+8- NK cells, and approximately half of circulating CD8+ T lymphocytes, coexpressed both granzymes A and B. In contrast, few circulating

APA, Harvard, Vancouver, ISO, and other styles

12

de Almeida, Alexandre S., Christina T. Fiske, Timothy R. Sterling, and Spyros A. Kalams. "Increased Frequency of Regulatory T Cells and T Lymphocyte Activation in Persons with Previously Treated Extrapulmonary Tuberculosis." Clinical and Vaccine Immunology 19, no. 1 (2011): 45–52. http://dx.doi.org/10.1128/cvi.05263-11.

Full text

Abstract:

ABSTRACTExtrapulmonary tuberculosis may be due to underlying immune compromise. Immunosuppressive regulatory T cells (Treg cells), and CD4+T lymphocytes in general, are important in the host immune response toMycobacterium tuberculosis. We evaluated T lymphocytes from patients after recovery from extrapulmonary tuberculosis, which may reflect conditions beforeM. tuberculosisinfection. A case-control study was conducted among HIV-uninfected adults with previously treated extrapulmonary tuberculosis and 3 sets of controls: (i) subjects with previously treated pulmonary tuberculosis, (ii) close t

APA, Harvard, Vancouver, ISO, and other styles

13

Kwack, Kyu Hwan, and Hyeon-Woo Lee. "Progranulin Inhibits Human T Lymphocyte Proliferation by Inducing the Formation of Regulatory T Lymphocytes." Mediators of Inflammation 2017 (2017): 1–9. http://dx.doi.org/10.1155/2017/7682083.

Full text

Abstract:

We have examined the effect of progranulin (PGRN) on human T cell proliferation and its underlying mechanism. We show that PGRN inhibits the PHA-induced multiplication of T lymphocytes. It increases the number of iTregs when T lymphocytes are activated by PHA but does not do so in the absence of PHA. PGRN-mediated inhibition of T lymphocyte proliferation, as well as the induction of iTregs, was completely reversed by a TGF-β inhibitor or a Treg inhibitor. PGRN induced TGF-β secretion in the presence of PHA whereas it did not in the absence of PHA. Our findings indicate that PGRN suppresses T l

APA, Harvard, Vancouver, ISO, and other styles

14

Skerget, Matevz, Barbara Skopec, Darja Zontar, and Peter Cernelc. "Mobilization with cyclophosphamide reduces the number of lymphocyte subpopulations in the leukapheresis product and delays their reconstitution after autologous hematopoietic stem cell transplantation in patients with multiple myeloma." Radiology and Oncology 50, no. 4 (2016): 402–8. http://dx.doi.org/10.1515/raon-2016-0028.

Full text

Abstract:

Abstract Background Autologous hematopoietic stem cell transplantation is considered the standard of care for younger patients with multiple myeloma. Several mobilization regimens are currently used, most commonly growth factors alone or in combination with chemotherapy. The aim of our study was to investigate the differences in lymphocyte subpopulation counts between three different mobilization regimens on collection day, in the leukapheresis product and on day 15 after autologous hematopoietic stem cell transplantation. Patients and methods In total 48 patients were prospectively enrolled i

APA, Harvard, Vancouver, ISO, and other styles

15

Zhong, Xuemei, Chunyan Bai, and Thomas L. Rothstein. "Suppression of Negative Immune Regulators PD-1 and PD-L1 Expression on Lymphocytes by Inflammatory Cytokines." Blood 104, no. 11 (2004): 2663. http://dx.doi.org/10.1182/blood.v104.11.2663.2663.

Full text

Abstract:

Abstract The strength and duration of lymphocyte activation is determined by the net effect of positive and negative regulatory co-signaling molecules. The inhibitory receptor PD-1 and its ligand PD-L1 are both expressed on activated lymphocytes. Mice deficient of PD-1 or PD-L1 demonstrate lymphocyte hyperactivity and are prone to autoimmunity. We have shown that the expression and function of PD-1 on activated B lymphocytes can be down-regulated by certain inflammatory cytokines, rendering them resistant to PD-L1 mediated suppression. Here we further report that both PD-1 and PD-L1 expression

APA, Harvard, Vancouver, ISO, and other styles

16

Mohammadnia-Afrouzi, Mousa, Mehdi Shahbazi, Sedigheh Baleghi Damavandi, Ghasem Faghanzadeh Ganji, and Soheil Ebrahimpour. "Regulatory T-cell: Regulator of Host Defense in Infection." Journal of Molecular Biology Research 7, no. 1 (2017): 9. http://dx.doi.org/10.5539/jmbr.v7n1p9.

Full text

Abstract:

Based on diverse activities and production of several cytokines, T lymphocytes and T helper cells are divided into Th1, Th2, Th17 and regulatory T-cell (T regs) subsets based on diverse activities and production of several cytokines. Infectious agents can escape from host by modulation of immune responses as effector T-cells and Tregs. Thus, regulatory T-cells play a critical role in suppression of immune responses to infectious agents such as viruses, bacteria, parasites and fungi and as well as preserving immune homeostasis. However, regulatory T-cell responses can advantageous for the body

APA, Harvard, Vancouver, ISO, and other styles

17

Vitales-Noyola, Marlen, Brenda Oceguera-Maldonado, Perla Niño-Moreno, et al. "Patients with Systemic Lupus Erythematosus Show Increased Levels and Defective Function of CD69+ T Regulatory Cells." Mediators of Inflammation 2017 (2017): 1–9. http://dx.doi.org/10.1155/2017/2513829.

Full text

Abstract:

T regulatory (Treg) cells have a key role in the pathogenesis of chronic inflammatory and autoimmune diseases. A CD4+CD69+ T cell subset has been described that behaves as Treg lymphocytes, exerting an important immune suppressive effect. In this study, we analyzed the levels and function of CD4+CD69+ Treg cells in patients with systemic lupus erythematosus (SLE). Blood samples were obtained from 22 patients with SLE and 25 healthy subjects. Levels of CD4+CD69+ Treg cells were analyzed by multiparametric flow cytometry, and their function was measured by an assay of suppression of lymphocyte a

APA, Harvard, Vancouver, ISO, and other styles

18

Moskalev, A. V., B. Yu Gumilevskiy, A. V. Apchel та V. N. Tsygan. "Т- lymphocytes - «censorial» cells of immune system". Bulletin of the Russian Military Medical Academy 21, № 2 (2019): 191–97. http://dx.doi.org/10.17816/brmma25943.

Full text

Abstract:

The characteristic of population Т-lymphocytes is presented. The variety of effects of these cells is connected with presence of many subpopulations which name small subpopulations helper T-lymphocytes: Тh1, Тh2, Тh3, Тh9, Тh17, Тh22. Mechanisms of activation of these cells and their role in development of mechanisms of the adaptive immune answer, and also possible variants of development of immune dysfunctions and an immune pathology are described. However, the leading part is allocated to the characteristic regulatory T-lymphocytes. From all subpopulations regulatory lymphocytes subpopulatio

APA, Harvard, Vancouver, ISO, and other styles

19

Marazuela, Mónica, María A. García-López, Nicté Figueroa-Vega, et al. "Regulatory T Cells in Human Autoimmune Thyroid Disease." Journal of Clinical Endocrinology & Metabolism 91, no. 9 (2006): 3639–46. http://dx.doi.org/10.1210/jc.2005-2337.

Full text

Abstract:

Abstract Context: T regulatory cells have a key role in the pathogenesis of autoimmune diseases in different animal models. However, less information is available regarding these cells in human autoimmune thyroid diseases (AITD). Objective: The objective of the study was to analyze different regulatory T cell subsets in patients with AITD. Design: We studied by flow cytometry and immunohistochemistry different T regulatory cell subsets in peripheral blood mononuclear cells (PBMCs) and thyroid cell infiltrates from 20 patients with AITD. In addition, the function of TREG lymphocytes was assesse

APA, Harvard, Vancouver, ISO, and other styles

20

Ma, Jinhui, Juncheng Ge, Fuqiang Gao, et al. "The Role of Immune Regulatory Cells in Nontraumatic Osteonecrosis of the Femoral Head: A Retrospective Clinical Study." BioMed Research International 2019 (November 20, 2019): 1–7. http://dx.doi.org/10.1155/2019/1302015.

Full text

Abstract:

The immunologic factors have been implicated in the pathogenesis of osteonecrosis. We aimed to investigate the potential role of immune regulatory cells in the development of osteonecrosis of femoral head (ONFH). Sixty-seven patients diagnosed with ONFH and fifty-eight age-, height-, and weight-matched healthy subjects were included in this retrospective study between September 2015 and September 2018. The flow cytometry was used to test the count, percentage, and ratio of T and B lymphocyte subsets in peripheral blood. The T and B lymphocyte levels were compared among different ARCO stages, C

APA, Harvard, Vancouver, ISO, and other styles

21

Vacani-Martins, Natalia, Marcelo Meuser-Batista, Otacilio C. Moreira та ін. "After Experimental Trypanosoma cruzi Infection, Dying Hepatic CD3+TCRαβ+B220+ T Lymphocytes Are Rescued from Death by Peripheral T Cells and Become Activated". Pathogens 9, № 9 (2020): 717. http://dx.doi.org/10.3390/pathogens9090717.

Full text

Abstract:

The unusual phenotype of CD3+ T lymphocyte expressing B220, a marker originally attributed to B lymphocytes, was first observed in the liver of Fas/Fas-L-deficient mice as a marker of apoptotic T lymphocytes. However, other CD3+B220+ T lymphocyte populations were later described in the periphery as functional cytotoxic or regulatory cells, for example. Then, in this work, we studied whether hepatic CD3+B220+ T lymphocytes could play a role in experimental Trypanosoma cruzi infection. In control and infected mice, we observed two subpopulations that could be discerned based on CD117 expression,

APA, Harvard, Vancouver, ISO, and other styles

22

Chen, J., J. Jiang, Y. Liu, et al. "Arsenite induces dysfunction of regulatory T cells through acetylation control of the Foxp3 promoter." Human & Experimental Toxicology 40, no. 1 (2020): 35–46. http://dx.doi.org/10.1177/0960327120934533.

Full text

Abstract:

Arsenic is known to cause damage to the body’s immune system by inducing epigenetic changes. However, the molecular mechanism of this damage remains elusive. Here, we report that arsenic disrupts the morphology of lymphocytes, decreases cell viability, and results in abnormal proportions of T lymphocyte subsets. Moreover, our results revealed that arsenic can reduce global acetylation of histone H4 at K16 (H4K16 ac) in lymphocytes via decreasing the level of males absent on the first but upregulates mRNA and protein levels of the forkhead/winged-helix box P3 ( Foxp3) gene by increasing the ace

APA, Harvard, Vancouver, ISO, and other styles

23

Baek, DS, TH Chung, YH Kim, SK Oh, KM So, and C. Park. "Changes in regulatory T cells in dogs with B-cell lymphoma and association with clinical tumour stage." Veterinární Medicína 62, No. 12 (2017): 647–53. http://dx.doi.org/10.17221/7/2015-vetmed.

Full text

Abstract:

Among several mechanisms that allow tumours to disarm the host immune system and thus to evade or suppress protective anti-tumour immunity, an important role for CD4<sup>+</sup>CD25<sup>+</sup>FoxP3<sup>+</sup> regulatory T cells (Tregs) has emerged. Numerous studies in humans have demonstrated increased Tregs in patients with carcinomas of the breast, lung, and pancreas, and this increased Treg has been correlated with poor prognosis. This study was performed (1) to investigate the percentage of Tregs in total lymphocytes of the peripheral blood in 12 canin

APA, Harvard, Vancouver, ISO, and other styles

24

Lee, V. W. S., Y. M. Wang, Y. P. Wang, et al. "Regulatory immune cells in kidney disease." American Journal of Physiology-Renal Physiology 295, no. 2 (2008): F335—F342. http://dx.doi.org/10.1152/ajprenal.00077.2008.

Full text

Abstract:

Lymphocytes and macrophages act as effector immune cells in the initiation and progression of renal injury. Recent data have shown that subpopulations of these immune cells (regulatory T lymphocytes and alternately-activated or regulatory macrophages) are potent modulators of tissue injury and repair in renal disease. Recent animal studies examining the therapeutic effect of these cells raise the exciting possibility that strategies targeting these cell types may be effective in treating and preventing kidney disease in humans. This review will describe their biological role in experimental ki

APA, Harvard, Vancouver, ISO, and other styles

25

Brody, Joshua D., Matthew J. Goldstein, Debra K. Czerwinski, and Ronald Levy. "Immunotransplantation preferentially expands T-effector cells over T-regulatory cells and cures large lymphoma tumors." Blood 113, no. 1 (2009): 85–94. http://dx.doi.org/10.1182/blood-2008-05-155457.

Full text

Abstract:

Abstract Ex vivo–expanded tumor-infiltrating lymphocytes infused into lymphodepleted recipients has clear antitumor efficacy. More practical sources of such antitumor lymphocytes would broaden the application of this approach. Previously, we described an in situ vaccination combining chemotherapy with intratumoral injection of CpG-enriched oligonucleotides, which induced T-cell immunity against established lymphoma. An ongoing clinical trial of this maneuver has demonstrated clinical responses in lymphoma patients. Here, we use this vaccine maneuver to generate immune cells for transfer into i

APA, Harvard, Vancouver, ISO, and other styles

26

Marshall, Neil A., Linsey E. Christie, Laura R. Munro, et al. "Immunosuppressive regulatory T cells are abundant in the reactive lymphocytes of Hodgkin lymphoma." Blood 103, no. 5 (2004): 1755–62. http://dx.doi.org/10.1182/blood-2003-07-2594.

Full text

Abstract:

Abstract Although immunosuppression has long been recognized in Hodgkin lymphoma (HL), the underlying basis for the lack of an effective immune response against the tumor remains unclear. The aim was to test our hypothesis that regulatory T cells dominate involved lymph nodes. The approach was to assay CD4+ T-cell function in HL-infiltrating lymphocytes (HLILs) and paired peripheral blood mononuclear cells (PBMCs) of 24 patients. Strikingly, unlike PBMCs, HLILs were anergic to stimulation with mitogen, primary, or recall antigens, mounting no proliferative responses and only rare T-helper 1 (T

APA, Harvard, Vancouver, ISO, and other styles

27

Trepel, M., A. Flammiger, L. Weisbach, et al. "Relationship of T lymphocytes, T regulatory cells, and B lymphocytes to clinical outcome in prostate cancer." Journal of Clinical Oncology 29, no. 15_suppl (2011): 4632. http://dx.doi.org/10.1200/jco.2011.29.15_suppl.4632.

Full text

APA, Harvard, Vancouver, ISO, and other styles

28

Popov, S. V., I. Yu Shmelkov, and S. V. Khaidukov. "Analysis of regulatory T lymphocytes in fungal infections." Medical Immunology (Russia) 22, no. 6 (2021): 1055–64. http://dx.doi.org/10.15789/1563-0625-aor-2047.

Full text

Abstract:

Morbidity and mortality rates in invasive mycoses determine the need to improve methods for their timely diagnosis by assessment the patients’ immune status. Evaluation of individual immune status allows the clinician to predict the development and course of fungal infections. At the same time, identification of opportunistic mycosis in immunocompetent patients should require a search for some hidden immune deficiency. Determining the cause of such immune defects can help develop an effective strategy for both etiotropic and immune therapy of patients with invasive mycoses. Currently, the func

APA, Harvard, Vancouver, ISO, and other styles

29

Chen, Jinfei, Anita Schmitt, Baoan Chen, et al. "Imatinib Inhibits Both CD4+ T Regulatory Cells and CD8+ T Lymphocytes Specifically Directed Against the Leukemia-Associated Antigen RHAMM/CD168." Blood 108, no. 11 (2006): 2201. http://dx.doi.org/10.1182/blood.v108.11.2201.2201.

Full text

Abstract:

Abstract Imatinib mesylate (IM, STI571, Gleevec®) is highly effective in the treatment of patients with chronic myelogenous leukemia (CML). In patients with residual disease or relapse after allogeneic stem cell transplantation (allo-SCT), the optimal strategy is a matter of debate: donor lymphocyte infusions (DLIs) alone, IM alone or a combination of both have been administered to CML patients in this clinical situation. As an impairment of anti-viral CD8+ T lymphocyte function by IM has been described, we questioned whether IM also affects specific anti-leukemic CD8+ T lymphocytes. Moreover,

APA, Harvard, Vancouver, ISO, and other styles

30

Radosavljevic, Gordana, Ivan Jovanovic, Tatjana Kanjevac, and Nebojsa Arsenijevic. "The role of regulatory T cells in the modulation of anti-tumor immune response." Srpski arhiv za celokupno lekarstvo 141, no. 3-4 (2013): 262–67. http://dx.doi.org/10.2298/sarh1304262r.

Full text

Abstract:

It has been shown that the loss of regulatory function by deple? + Regulatory T cells (Treg) represent a subset of CD4 T cells whose function is to suppress immune responses. Treg lymphocytes can be divided into two subsets: natural nTreg lymphocytes that are developed in the thymus and inducible iTreg lymphocytes, which originate from conventional T lymphocytes on the periphery. The majority of Treg lymphocytes express high levels of interleukin?2 (IL?2) receptor ? chain (CD25) and transcription factor FoxP3 (critical for the development and suppressor activity of iTreg lymphocytes). Cancer c

APA, Harvard, Vancouver, ISO, and other styles

31

Makarova, O. V., E. A. Postovalova, Yu Gao, and M. T. Dobrynina. "Sex differences of subpopulation composition of lymphocytes in the peripheral blood in experimental acute and chronic ulcerative colitis." Medical Immunology (Russia) 22, no. 1 (2020): 157–64. http://dx.doi.org/10.15789/1563-0625-sdo-1661.

Full text

Abstract:

We studied sex differences lymphocytes subpopulations of peripheral blood in adult C57Bl/6 mice during acute and chronic colitis, induced with 1% DSS. We measured subpopulations of lymphocytes with flow cytometry. We showed that in the control group the female mice had statistically significantly higher values of the relative number of regulatory and cytotoxic T lymphocytes comparing to the males. During acute colitis the females showed an increase in the relative number of Thelpers and a decrease of cytotoxic Tlymphocytes, which reflects the activation of immune response. The males had a decr

APA, Harvard, Vancouver, ISO, and other styles

32

Kang, Minkyung, Hyun-Su Lee, Jin Kyeong Choi, Cheng-Rong Yu, and Charles E. Egwuagu. "Deletion of Irf4 in T Cells Suppressed Autoimmune Uveitis and Dysregulated Transcriptional Programs Linked to CD4+ T Cell Differentiation and Metabolism." International Journal of Molecular Sciences 22, no. 5 (2021): 2775. http://dx.doi.org/10.3390/ijms22052775.

Full text

Abstract:

Interferon regulatory factor-4 (IRF4) and IRF8 regulate differentiation, growth and functions of lymphoid and myeloid cells. Targeted deletion of irf8 in T cells (CD4-IRF8KO) has been shown to exacerbate colitis and experimental autoimmune uveitis (EAU), a mouse model of human uveitis. We therefore generated mice lacking irf4 in T cells (CD4-IRF4KO) and investigated whether expression of IRF4 by T cells is also required for regulating T cells that suppress autoimmune diseases. Surprisingly, we found that CD4-IRF4KO mice are resistant to EAU. Suppression of EAU derived in part from inhibiting p

APA, Harvard, Vancouver, ISO, and other styles

33

Zahran, Asmaa M., Khaled Saad, Mohamed Gamil Abo-Elela, et al. "Down-regulation of Regulatory T-cells in Children With Gaucher Disease Under Enzyme Replacement Therapy." Clinical and Applied Thrombosis/Hemostasis 25 (January 1, 2019): 107602961988968. http://dx.doi.org/10.1177/1076029619889685.

Full text

Abstract:

Gaucher disease (GD) is one of the most important lysosomal storage disorders. T-lymphocytes perform and regulate many of the immune processes and play a major role in immune homeostasis. Studies have shown that GD causes impairment in T-lymphocyte functions, although the role and status of T-lymphocytes in GD are still under investigation. It is still not fully known how GD leads to the altered biochemical and immunological cellular functions observed in the disease. Our study aimed to evaluate the variations of regulatory T-lymphocytes (Tregs) in 20 Egyptian children with GD under enzyme rep

APA, Harvard, Vancouver, ISO, and other styles

34

Hampras, Shalaka S., Mary Nesline, Paul K. Wallace, et al. "Predictors of Immunosuppressive Regulatory T Lymphocytes in Healthy Women." Journal of Cancer Epidemiology 2012 (2012): 1–8. http://dx.doi.org/10.1155/2012/191090.

Full text

Abstract:

Immunosuppressive regulatory T (Treg) cells play an important role in antitumor immunity, self-tolerance, transplantation tolerance, and attenuation of allergic response. Higher proportion of Treg cells has been observed in peripheral blood of cancer cases compared to controls. Little is known about potential epidemiological predictors of Treg cell levels in healthy individuals. We conducted a cross-sectional study including 75 healthy women, between 20 and 80 years of age, who participated in the Data Bank and BioRepository (DBBR) program at Roswell Park Cancer Institute (RPCI), Buffalo, NY,

APA, Harvard, Vancouver, ISO, and other styles

35

Alunno, Alessia, Mirko Manetti, Sara Caterbi, et al. "Altered Immunoregulation in Rheumatoid Arthritis: The Role of Regulatory T Cells and Proinflammatory Th17 Cells and Therapeutic Implications." Mediators of Inflammation 2015 (2015): 1–12. http://dx.doi.org/10.1155/2015/751793.

Full text

Abstract:

In recent years several studies investigated the role of T lymphocyte subpopulations in the pathogenesis of rheumatoid arthritis (RA). Pathogenic Th17 cells mediate pannus growth, osteoclastogenesis, and synovial neoangiogenesis; hence they are key players in the development of the disease. On the other hand, regulatory T (Treg) cells are a T cell subset whose peculiar function is to suppress autoreactive lymphocytes. The imbalance between Th17 and Treg cells has been identified as a crucial event in the pathogenesis of RA. In addition, the effects of currently employed RA therapeutic strategi

APA, Harvard, Vancouver, ISO, and other styles

36

Salama, Paul, Michael Phillips, Fabienne Grieu, et al. "Tumor-Infiltrating FOXP3+ T Regulatory Cells Show Strong Prognostic Significance in Colorectal Cancer." Journal of Clinical Oncology 27, no. 2 (2009): 186–92. http://dx.doi.org/10.1200/jco.2008.18.7229.

Full text

Abstract:

Purpose To determine the prognostic significance of FOXP3+ lymphocyte (Treg) density in colorectal cancer compared with conventional histopathologic features and with CD8+ and CD45RO+ lymphocyte densities. Patients and Methods Tissue microarrays and immunohistochemistry were used to assess the densities of CD8+, CD45RO+, and FOXP3+ lymphocytes in tumor tissue and normal colonic mucosa from 967 stage II and stage III colorectal cancers. These were evaluated for associations with histopathologic features and patient survival. Results FOXP3+ Treg density was higher in tumor tissue compared with n

APA, Harvard, Vancouver, ISO, and other styles

37

Gasteiger, Georg, Saskia Hemmers, Matthew A. Firth, et al. "IL-2–dependent tuning of NK cell sensitivity for target cells is controlled by regulatory T cells." Journal of Experimental Medicine 210, no. 6 (2013): 1167–78. http://dx.doi.org/10.1084/jem.20122462.

Full text

Abstract:

The emergence of the adaptive immune system took a toll in the form of pathologies mediated by self-reactive cells. Regulatory T cells (T reg cells) exert a critical brake on responses of T and B lymphocytes to self- and foreign antigens. Here, we asked whether T reg cells are required to restrain NK cells, the third lymphocyte lineage, whose features combine innate and adaptive immune cell properties. Although depletion of T reg cells led to systemic fatal autoimmunity, NK cell tolerance and reactivity to strong activating self- and non-self–ligands remained largely intact. In contrast, missi

APA, Harvard, Vancouver, ISO, and other styles

38

Churov, A. V., A. V. Novitskaya, S. N. Kolomeichuk, and E. K. Oleinik. "INDICES OF CELL-MEDIATED IMMUNITY IN RHEUMATOID ARTHRITIS: THE ROLE OF CYTOMEGALOVIRUS INFECTION." Russian Clinical Laboratory Diagnostics 64, no. 2 (2019): 98–103. http://dx.doi.org/10.18821/0869-2084-2019-64-2-98-103.

Full text

Abstract:

The pathogenesis of rheumatoid arthritis (RA) is driven by a combined action of genetic and environmental factors, which can upset the balance between the effector and regulatory components of the immune system. An important actor in maintaining such balance is T cells, especially regulatory T lymphocytes (Treg), but the mechanisms behind the functioning of T cell subpopulations and the roles of individual etiological factors in RA have not been fully elucidated. This study aimed to investigate the indices of cell-mediated immunity, especially T- and Treg cells, in RA patients depending on the

APA, Harvard, Vancouver, ISO, and other styles

39

Shu, Chin-Chung, Sheng-Wei Pan, Jia-Yih Feng, et al. "The Clinical Significance of Programmed Death-1, Regulatory T Cells and Myeloid Derived Suppressor Cells in Patients with Nontuberculous Mycobacteria-Lung Disease." Journal of Clinical Medicine 8, no. 5 (2019): 736. http://dx.doi.org/10.3390/jcm8050736.

Full text

Abstract:

Background: Increasing expression of programmed death-1 (PD-1) in patients with nontuberculous mycobacteria lung disease (NTM-LD) has been reported, but its role in clinical characteristics and outcomes remains unclear. Methods: We enrolled 96 participants, including 46 with Mycobacterium avium complex (MAC)-LD, 23 with M. abscessus (MAB)-LD, and 27 controls. We measured expressions of PD-1, cytotoxic T-lymphocyte antigen-4 (CTLA-4) and regulatory T (Treg) cells on CD4+ lymphocytes and myeloid-derived suppressor cells (MDSCs) and analyzed their association with clinical features and radiograph

APA, Harvard, Vancouver, ISO, and other styles

40

Alvarez, Carla, Carolina Rojas, Leticia Rojas, Emilio A. Cafferata, Gustavo Monasterio, and Rolando Vernal. "Regulatory T Lymphocytes in Periodontitis: A Translational View." Mediators of Inflammation 2018 (2018): 1–10. http://dx.doi.org/10.1155/2018/7806912.

Full text

Abstract:

Periodontitis is a chronic immuno-inflammatory disease in which the disruption of the balance between host and microbiota interactions is key to the onset and progression of the disease. The immune homeostasis associated with periodontal health requires a regulated immuno-inflammatory response, during which the presence of regulatory T cells (Tregs) is essential to ensure a controlled response that minimizes collateral tissue damage. Since Tregs modulate both innate and adaptive immunity, pathological conditions that may resolve by the acquisition of immuno-tolerance, such as periodontitis, ma

APA, Harvard, Vancouver, ISO, and other styles

41

Kravchenko, P. N., G. A. Zhulai, A. V. Churov, et al. "Subpopulations of regulatory T-lymphocytes in the peripheral blood of patients with rheumatoid arthritis." Annals of the Russian academy of medical sciences 71, no. 2 (2016): 148–53. http://dx.doi.org/10.15690/vramn656.

Full text

Abstract:

Background: Rheumatoid arthritis (RA) is an inflammatory rheumatic disease, associated with a dysfunction of the T cell-mediated tolerance and leading to the disability of working population. The regulatory CD4+ T cells are play important role in the regulation of autoimmunity and can suppress immune responses. With that, there is no consensus on the content of these lymphocytes and their role in the pathogenesis of RA. Objective: The aim of the study was to assess the content of peripheral blood regulatory T cells (Treg) according to the expression of membrane markers CD4, CD25, CD127 and int

APA, Harvard, Vancouver, ISO, and other styles

42

Dong, Chen. "Cytokine Regulation and Function in T Cells." Annual Review of Immunology 39, no. 1 (2021): 51–76. http://dx.doi.org/10.1146/annurev-immunol-061020-053702.

Full text

Abstract:

T lymphocytes, the major effector cells in cellular immunity, produce cytokines in immune responses to mediate inflammation and regulate other types of immune cells. Work in the last three decades has revealed significant heterogeneity in CD4+ T cells, in terms of their cytokine expression, leading to the discoveries of T helper 1 (Th1), Th2, Th17, and T follicular helper (Tfh) cell subsets. These cells possess unique developmental and regulatory pathways and play distinct roles in immunity and immune-mediated pathologies. Other types of T cells, including regulatory T cells and γδ T cells, as

APA, Harvard, Vancouver, ISO, and other styles

43

de Andrade Pereira, Luciana, Otávio Cesar Carvalho Guimarães Baiocchi, Joyce M. K. Silva, et al. "Impact of Major Orthopedic Surgery On Regulatory CD4+ T Lymphocytes and Cytokines in Transfused and Non-Transfused Patients." Blood 120, no. 21 (2012): 2286. http://dx.doi.org/10.1182/blood.v120.21.2286.2286.

Full text

Abstract:

Abstract Abstract 2286 It is known that major surgery and allogeneic blood transfusion mediate immunosuppression by interfering on cytokine secretion, lymphocyte count and cytotoxic response. However, which cytokines and lymphocyte subpopulations participate in such immunosuppressive state remains poorly understood. Regulatory T cells (Tregs) are suppressive CD4(+) cells with a central role in immunosuppression of trauma victims, cancer patients, and transplant recipients. Several markers have been identified with regulatory properties, such as FOXP3, CTLA-4, GITR and the recently described CD

APA, Harvard, Vancouver, ISO, and other styles

44

Wekerle, H., D. Sun, R. L. Oropeza-Wekerle, and R. Meyermann. "Immune reactivity in the nervous system: modulation of T-lymphocyte activation by glial cells." Journal of Experimental Biology 132, no. 1 (1987): 43–57. http://dx.doi.org/10.1242/jeb.132.1.43.

Full text

Abstract:

The vertebrate central nervous system (CNS) has been traditionally thought to be inaccessible for the passenger lymphocytes of the immune system. This does not seem to be the case: activated T-lymphocytes can readily cross the endothelial blood-brain barrier (BBB) and some glial cells, notably the astrocytes, seem to be programmed to act as most efficient and complex partners for antigen-specific T-lymphocytes. We used myelin basic protein (MBP) specific permanent rat T-lymphocyte lines as probes to assess the immune status of the CNS. These cells, upon activation in vitro, are able to transfe

APA, Harvard, Vancouver, ISO, and other styles

45

Zhou, Yuetao, Madhuri S. Salker, Britta Walker, et al. "Acid Sphingomyelinase (ASM) is a Negative Regulator of Regulatory T Cell (Treg) Development." Cellular Physiology and Biochemistry 39, no. 3 (2016): 985–95. http://dx.doi.org/10.1159/000447806.

Full text

Abstract:

Background/Aims: Regulatory T cell (Treg) is required for the maintenance of tolerance to various tissue antigens and to protect the host from autoimmune disorders. However, Treg may, indirectly, support cancer progression and bacterial infections. Therefore, a balance of Treg function is pivotal for adequate immune responses. Acid sphingomyelinase (ASM) is a rate limiting enzyme involved in the production of ceramide by breaking down sphingomyelin. Previous studies in T-cells have suggested that ASM is involved in CD28 signalling, T lymphocyte granule secretion, degranulation, and vesicle she

APA, Harvard, Vancouver, ISO, and other styles

46

Ye, Jian, Xingxu Huang, Eddy C. Hsueh, et al. "Human regulatory T cells induce T-lymphocyte senescence." Blood 120, no. 10 (2012): 2021–31. http://dx.doi.org/10.1182/blood-2012-03-416040.

Full text

Abstract:

Abstract Regulatory T (Treg) cells have broad suppressive activity on host immunity, but the fate and function of suppressed responder T cells remains largely unknown. In the present study, we report that human Treg cells can induce senescence in responder naive and effector T cells in vitro and in vivo. Senescent responder T cells induced by human Treg cells changed their phenotypes and cytokine profiles and had potent suppressive function. Furthermore, Treg-mediated molecular control of senescence in responder T cells was associated with selective modulation of p38 and ERK1/2 signaling and c

APA, Harvard, Vancouver, ISO, and other styles

47

Barchet, Winfried, Jeffrey D. Price, Marina Cella, et al. "Complement-induced regulatory T cells suppress T-cell responses but allow for dendritic-cell maturation." Blood 107, no. 4 (2006): 1497–504. http://dx.doi.org/10.1182/blood-2005-07-2951.

Full text

Abstract:

Concurrent activation of the T-cell receptor (TCR) and complement regulator CD46 on human CD4+ T lymphocytes induces Tr1-like regulatory T cells that suppress through IL-10 secretion bystander T-cell proliferation. Here we show that, despite their IL-10 production, CD46-induced T-regulatory T cells (Tregs) do not suppress the activation/maturation of dendritic cells (DCs). DC maturation by complement/CD46-induced Tregs is mediated through simultaneous secretion of GM-CSF and soluble CD40L, factors favoring DC differentiation and reversing inhibitory effects of IL-10. Thus, CD46-induced Tregs p

APA, Harvard, Vancouver, ISO, and other styles

48

Unitt, Esther, Simon M. Rushbrook, Aileen Marshall, et al. "Compromised lymphocytes infiltrate hepatocellular carcinoma: The role of T-regulatory cells." Hepatology 41, no. 4 (2005): 722–30. http://dx.doi.org/10.1002/hep.20644.

Full text

APA, Harvard, Vancouver, ISO, and other styles

49

Tabellini, L., P. Haeusermann, M. E. Flower, et al. "328: Changes in lymphocytes and regulatory T cells in chronic GVHD." Biology of Blood and Marrow Transplantation 13, no. 2 (2007): 119. http://dx.doi.org/10.1016/j.bbmt.2006.12.333.

Full text

APA, Harvard, Vancouver, ISO, and other styles

50

Kean, Leslie S., Sharon Sen, Olusegun Onabajo, et al. "Significant mobilization of both conventional and regulatory T cells with AMD3100." Blood 118, no. 25 (2011): 6580–90. http://dx.doi.org/10.1182/blood-2011-06-359331.

Full text

Abstract:

AbstractIn this study, we used the rhesus macaque model to determine the impact that AMD3100 has on lymphocyte mobilization, both alone and in combination with G-CSF. Our results indicate that, unlike G-CSF, AMD3100 substantially mobilizes both B and T lymphocytes into the peripheral blood. This led to significant increases in the peripheral blood content of both effector and regulatory T-cell populations, which translated into greater accumulation of these cells in the resulting leukapheresis products. Notably, CD4+/CD25high/CD127low/FoxP3+ Tregs were efficiently mobilized with AMD3100-contai

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!