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Dissertations / Theses on the topic 'Regulatory T cells subsets'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Lei, Hong. "Human natural regulatory T cells subsets." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2014. http://dx.doi.org/10.18452/16958.

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Regulatorische T-Zellen (Treg) eröffnen neue immuntherapeutische Wege zur Kontrolle unerwünschter Immunreaktionen, jedoch wirft die Heterogenität dieser Zellen die Frage auf, welche Treg-Population für die klinische Anwendung. Darauf basierend werden in dieser Arbeit drei Fragestellungen bearbeitet: i) Bestimmung der Häufigkeit von Tregs und deren Subpopulationen in verschiedenen Altersgruppen bei Empfängern einer Organtransplantation (Tx) und einer gesunden Kontrollgruppe; ii) Vergleich der Suppressorkapazität verschiedener Treg-Populationen und in vitro-Expansion der Zellen unter Erhaltung i

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2

Putheti, Prabhakar. "CD4+CD25+ T regulatory cells in multiple sclerosis /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7349-962-5.

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3

Cao, Duojia. "CD25+CD4+ regulatory T cells in rheumatic disease /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-178-4/.

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4

Maynard, Craig Lueland. "IL-10-competent regulatory T cells development, phenotype and function /." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2007. https://www.mhsl.uab.edu/dt/2009r/maynard.pdf.

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5

Hirani, S. "The characterisation of human umbilical cord blood regulatory T cell subsets." Thesis, University College London (University of London), 2012. http://discovery.ucl.ac.uk/1344048/.

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Umbilical cord blood (CB) is recognised to be a valuable alternative to bone marrow (BM) as a source of hematopoietic stem cells (HSC). The occurrence of Graft vs. Host Disease (GvHD) after CB transplantation has been reported to be less severe in comparison to BM transplants. In addition to the naive state of immune cells, the action of immuno-suppressive cells such as regulatory T cells (Treg) may contribute to the positive aspects observed in CB transplants. This study investigated the phenotypic and functional characteristics of CB Treg and their potential for expansion in culture. In addi

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6

Booth, Nicola Jane. "The characterisation of human regulatory T cell subsets in ageing and atopy." Thesis, University College London (University of London), 2010. http://discovery.ucl.ac.uk/20160/.

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The immune system must be controlled to prevent damage caused by inappropriate responses and extended inflammation. Regulatory T cells (Tregs), known to be generated by the thymus, must be maintained in the face of an ever-increasing human lifespan and associated thymic atrophy in order to protect the host, but whether they are maintained by expansion of pre-existing Tregs or conversion of conventional T cells is not yet known. There are known to be two subsets of FOXP3+ regulatory T cells: naive and memory cells, expressing CD45RA and CD45RO respectively. In this work the characteristics of C

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7

Lei, Hong [Verfasser], Hans-Dieter [Akademischer Betreuer] Volk, Richard [Akademischer Betreuer] Lucius, and Petra [Akademischer Betreuer] Reinke. "Human natural regulatory T cells subsets : functional characterization and T cell receptor repertoire analysis / Hong Lei. Gutachter: Hans-Dieter Volk ; Richard Lucius ; Petra Reinke." Berlin : Humboldt Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2014. http://d-nb.info/1051677475/34.

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8

Kalra, Seema. "Characterisation of pathogenic T helper and T regulatory cell subsets in relapse and progression in multiple sclerosis." Thesis, Keele University, 2017. http://eprints.keele.ac.uk/4215/.

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Multiple Sclerosis (MS) is one of the commonest disabling neurological diseases affecting the young in the developed world. It affects the central nervous system (CNS) and is characterised by inflammation with neuronal demyelination /degeneration and failure of remyeli nation/regeneration. Inflammation is present throughout the course of the disease though it differs qualitatively and/or quantitatively in different phases. T cells are the central players in the immune processes and more so in an autoimmune disease like MS. Autopsy studies continue to add to our understanding of CNS inflammatio

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9

Barra, Melanie Marianne [Verfasser], and Markus [Akademischer Betreuer] Feuerer. "Transcription factor 7 limits regulatory T cell generation and influences peripheral T cell subsets / Melanie Marianne Barra ; Betreuer: Markus Feuerer." Heidelberg : Universitätsbibliothek Heidelberg, 2014. http://d-nb.info/1180735056/34.

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10

Wendering, Désirée Jacqueline [Verfasser]. "Regulatory T cells in adoptive immunotherapy: from subset characterization to functional testing / Désirée Jacqueline Wendering." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2021. http://d-nb.info/1228860807/34.

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11

Zettlmeissl, Eva Christine Verfasser], and Peter [Akademischer Betreuer] [Kremsner. "The influence of maternal Loa loa and Mansonella perstans infection on the distribution of Th1, Th17 and T regulatory T cell subsets in cord blood / Eva Christine Zettlmeissl ; Betreuer: Peter G. Kremsner." Tübingen : Universitätsbibliothek Tübingen, 2015. http://d-nb.info/1163664650/34.

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12

Mottet, Christian. "Biology of regulatory T cells." Thesis, University of Oxford, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.433353.

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13

Thompson, Claire. "Characterisation of regulatory T cells." Thesis, University of Oxford, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.436941.

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14

Lindqvist, Camilla. "T Regulatory Cells – Friends or Foes?" Doctoral thesis, Uppsala universitet, Enheten för klinisk immunologi, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-128837.

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T regulatory cells (Tregs) have been extensively studied in patients with cancer or autoimmunity. These cells hamper the immune system’s ability to clear tumor cells in cancer patients. In autoimmune diseases, on the other hand, they are not able to restrain autoreactive immune responses. If we manage to understand Tregs and their role in health and diseases we may be able to develop better immunomodulatory therapies. Early studies demonstrated that tolerance was maintained by a subset of CD25+ T-cells. CD25 was the earliest marker for Tregs and is still often used to define these cells. Sever

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15

Kottoor, Sherine Hermangild. "Regulatory T cells in human uveitis." Thesis, University of Birmingham, 2011. http://etheses.bham.ac.uk//id/eprint/3000/.

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Regulatory T cells (Treg) are critical for the maintenance of tolerance to self and control of inflammation. Defects in Treg have been reported for a number of autoimmune and inflammatory diseases. In this thesis I wished to determine whether there are quantitative and/ or qualitative defects of Treg in patients with idiopathic non-infectious uveitis. Using stringent gating procedures, an increased frequency of CD4+CD25highCD127low Treg was observed in the peripheral blood of acute anterior uveitis (AAU) patients but not those with chronic disease. Treg from both acute and chronic anterior uve

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16

Mjösberg, Jenny. "Regulatory T cells in human pregnancy." Doctoral thesis, Linköpings universitet, Klinisk immunologi, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-53619.

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During pregnancy, fetal tolerance has to be achieved without compromising the immune integrity of the mother. CD4+CD25highFoxp3+ regulatory cells (Tregs) have received vast attention as key players in immune regulation. However, the identification of human Tregs is complicated by their similarity to activated nonsuppressive T cells. The general aim of this thesis was to determine the antigen specificity, frequency, phenotype and function of Tregs in first to second trimester healthy and severe early-onset preeclamptic human pregnancy. Regarding antigen specificity, we observed that in healthy

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17

Carson, Bryan David. "Impaired T cell receptor signaling in regulatory T cells /." Thesis, Connect to this title online; UW restricted, 2006. http://hdl.handle.net/1773/8337.

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18

Stefkova, Martina. "Regulatory T cells control the CD4 T cell repertoire." Doctoral thesis, Universite Libre de Bruxelles, 2016. https://dipot.ulb.ac.be/dspace/bitstream/2013/233151/3/Table.pdf.

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Des études récentes menées chez l’homme et la souris ont suggéré que la diversité du répertoire TCR pourrait jouer un rôle dans la protection contre des pathogènes à haut pouvoir mutagène. Afin d’étudier le répertoire des lymphocytes T CD4, nous avons utilisé un modèle de souris TCRβ transgéniques exprimant une chaine β spécifique du peptide env122-141 dans le contexte du MHCII. Suite à l’immunisation des souris TCRβ transgéniques avec des cellules dendritiques pulsées avec le peptide env, une rapide prolifération et une restriction du répertoire des lymphocytes T Vα2 CD4 spécifiques est obser

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19

Dittmer, Marie. "Influence of regulatory T cells on oligodendrocyte lineage cells." Thesis, Queen's University Belfast, 2017. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.725831.

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One of the greatest unmet clinical needs in demyelinating diseases such as Multiple Sclerosis (MS) is to provide therapies that actively enhance the process of myelin regeneration (remyelination) in the central nervous system (CNS). Uncovering the mechanisms that govern remyelination and developing novel treatments will prove highly beneficial to patients’ quality of life. Oligodendrocytes, the myelinating cells of the CNS, play a central role in remyelination and originate from oligodendrocyte progenitor cells (OPCs). It has been shown that cells of the adaptive immune system, particularly CD

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20

Lopes, Ana Paula Pinheiro. "Expression of CXCR3 in different T cells subsets in rheumatoid arthritis." Master's thesis, Universidade de Aveiro, 2015. http://hdl.handle.net/10773/15471.

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Mestrado em Bioquímica - Bioquímica Clínica<br>Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammatory polyarthritis as consequence, at least in part, of a T cell-driven inflammation in the synovial membrane, frequently associated with the production of pro-inflammatory cytokines, contributing for ongoing inflammation. CXCR3 have been implicated in RA, since it is known its ability to modulate migration and in addition an increased concentration of its ligands has been reported in RA. Hence in this study it was evaluated the frequency and absolute number of cir

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21

Jarvis, Lorna Beth. "Autoreactive CD8+ regulatory T cells in spondyloarthritis." Thesis, University of Cambridge, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.605067.

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There have been substantial advances in our understanding of the CD4+CD25+ regulatory T cell subset, but the possibility of an equivalent regulatory subset within the CD8+ T cell population has received less attention. In the course of studies investigating immunological abnormalities in patients with the inflammatory arthritis Ankylosing Spondylitis (AS), novel human CD8+ T cells that have a regulatory phenotype and function have been identified. CD8+/TCRαβ+ T cells were isolated from the peripheral blood of both AS patients and healthy donors and subsequently expanded as T cell lines using a

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22

Pye, Seonaid M. "Suicide gene therapy and regulatory T cells." Thesis, Imperial College London, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.510736.

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23

Chen, Ye. "Induced regulatory T cells in transplantation tolerance." Thesis, University of Oxford, 2010. http://ora.ox.ac.uk/objects/uuid:cffc275b-d32c-495e-a1da-55421a57e7e7.

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Induced regulatory T cells (iTreg) play an important role in the induction of tolerance to self and non-self antigens. Harnessing their suppressive potential has therapeutic implications for the treatment of autoimmune conditions and transplant rejection. Although the role of TGFβ-conditioned iTreg in natural and therapeutic tolerance is indisputable, their mechanism of action as well as factors that influence their function and stability in vivo remain unclear. Here it is shown that TGFβ-conditioning of T cells in the absence of any Foxp3 expression is insufficient for conferring a

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24

Alexander, Carla-Maria Alana. "T regulatory cells and the germinal center." Diss., University of Iowa, 2011. https://ir.uiowa.edu/etd/1117.

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Germinal center (GC) reactions are central features of T cell-driven B cell responses, and the site where antibody (Ab) producing cells and memory B cells are generated. Within GCs, a range of complex cellular and molecular events occur which are critical for the generation of high affinity Abs. These processes require exquisite regulation not only to ensure the production of desired Abs, but to minimize unwanted autoreactive or low affinity Abs. To assess whether T regulatory cells (Treg) participate in the control of GC responses, immunized mice were treated with either an anti-glucocorticoi

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25

Sayin, Ismail. "Characterization of human T follicular regulatory cells." Case Western Reserve University School of Graduate Studies / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=case1560336991188191.

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26

Ling, Eleanor Mary. "Regulatory T cells in human allergic disease." Thesis, Imperial College London, 2004. http://hdl.handle.net/10044/1/11369.

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27

Rigby, Mark R. "R T 6: a Bifunctional Protein of Regulatory T Cells." eScholarship@UMMS, 1995. http://escholarship.umassmed.edu/gsbs_diss/283.

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The immune system is a complex network of cells and molecules that is a powerful and necessary defense mechanism to protect the host from pathogens. When this system is non-functional or dysregulated, the host is susceptible to takeover or attack against self, both with often lethal sequelae. Over the past century remarkable advances have been made in understanding how the immune system functions and how to manipulate this knowledge for human benefit. One strategy used to understand immune system function is to determine how the activity of immune system cells is modulated by the proteins thes

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28

Hansson, Johan. "Activation and differentiation of cytotoxic T lymphocytes identification of district CTL subsets in the rat /." Lund : Dept. of Tumor Immunology, the Wallenberg Laboratory, 1994. http://catalog.hathitrust.org/api/volumes/oclc/39158589.html.

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29

Wang, Adele Y. "Phenotypic and functional characterization of T regulatory cells." Thesis, University of British Columbia, 2012. http://hdl.handle.net/2429/43462.

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FOXP3⁺ T regulatory cells (Tregs) normally function to restrain immune responses, but when their activities go awry diseases such as autoimmunity and cancer can result. Animal models have proven that enhancing or inhibiting the function of Tregs is an effective way to prevent, and in some cases cure, many immune-mediated diseases. Approaches to specifically modulate the activity of Tregs are already being translated to humans, yet we know remarkably little about how Tregs achieve their potent immunosuppressive effects. The aim of this research was to further understand the factors that regulat

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30

Demirkiran, Ahmet. "Dynamics of regulatory T cells in liver transplantation." [S.l.] : Rotterdam : [The Author] ; Erasmus University [Host], 2007. http://hdl.handle.net/1765/10694.

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31

Zaidi, Irfan ul Hassan. "Role of t-regulatory cells in HIV_2 infection." Thesis, Open University, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.542452.

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32

Nadal-Melsio, Elisabet. "Regulatory T cells after allogeneic stem cell transplantation." Thesis, Imperial College London, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.523746.

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33

Hamilton, Alexander Brian. "Immune functions & mechanisms of regulatory T cells." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.648192.

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34

Lawson, Catherine Ann. "CD4+CD25high regulatory T cells in rheumatoid arthritis." Thesis, University of Leeds, 2008. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.496533.

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35

Mavin, Emily. "Regulatory T cells in haematopoietic stem cell transplantation." Thesis, University of Newcastle upon Tyne, 2014. http://hdl.handle.net/10443/2731.

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Graft-versus-host disease (GvHD) remains the main complication associated with haematopoietic stem cell transplantation (HSCT). GvHD is caused by allo-reactive donor T cells mounting an attack against specific target tissues. CD4+CD25HiFoxp3+ regulatory T cells have been shown to modulate GvHD in vitro and also in vivo animal models. More recently early stage clinical trials have described the successful use of Treg to reduce the incidence of GvHD following HSCT. The aim of this study was to investigate further the suppressive mechanisms by which Treg are able to modulate GvHD and assess the i

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36

Raynor, Jana L. "Regulatory T Cell Homeostasis in Aging." University of Cincinnati / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1416570329.

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37

Chen, Hairong [Verfasser]. "Functional analysis of candidate regulatory genes in regulatory T cells / Hairong Chen." Hannover : Bibliothek der Tierärztlichen Hochschule Hannover, 2013. http://d-nb.info/1032432594/34.

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38

Kawamura, Kazuko. "Virus-stimulated plasmacytoid dendritic cells induce CD4[+] cytotoxic regulatory T cells." Kyoto University, 2006. http://hdl.handle.net/2433/143873.

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39

Vanderleyden, Ine. "Follicular regulatory T cell migration and differentiation." Thesis, University of Cambridge, 2019. https://www.repository.cam.ac.uk/handle/1810/288422.

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The germinal centre (GC) response is critical for generating highly effective humoral immune responses and immunological memory that forms the basis of successful immunisation. Control of the output of the GC response requires Follicular regulatory T (Tfr) cells, a subset of Foxp3+ Treg cells located within germinal centres. Tfr cells were first characterised in detail in 2011 and because of this relatively little is known about the exact role of Tfr cells within the GC, and the mechanism/s through which they exert their suppressive function. At the outset of this work, the major barrier to un

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40

Himmel, Megan Elizabeth. "Phenotypic and functional characterization of T cells and Foxp3⁺ T regulatory cells in inflammatory bowel disease : steps towards T regulatory cell therapy in mucosal disease." Thesis, University of British Columbia, 2012. http://hdl.handle.net/2429/42517.

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Because of their potent suppressive capacity and critical role in the normal function of the human immune system, T regulatory cells (Tregs) have long been considered candidates for the therapeutic treatment of autoimmune and chronic inflammatory diseases. However, the clinical implementation of these cells has proven challenging in practice, in part due to a lack of knowledge surrounding this T cell subset. Specifically, an evaluation of the unique functions of individual Treg cell lineages, along with a comprehensive investigation of the non-suppressive capacities of these cells, including c

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41

Soper, David Michael. "Interleukin-2 receptor and T cell receptor signaling in regulatory T cells /." Thesis, Connect to this title online; UW restricted, 2007. http://hdl.handle.net/1773/8344.

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42

Urbieta, Maitee. "Regulatory T Cells and Hematopoiesis in Bone Marrow Transplantation." Scholarly Repository, 2010. http://scholarlyrepository.miami.edu/oa_dissertations/463.

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CD4+CD25+FoxP3+ regulatory T cells (Treg) possess the capacity to modulate both adaptive and innate immunity. Due to their suppressive nature, Treg cells have been studied and tested in a variety of scenarios in an attempt to ameliorate undesired immune responses. While graft versus host disease (GVHD) has in fact emerged as the first clinical application for human Treg cells (Riley et al. 2009), equally important are issues concerning hematopoietic engraftment and immune reconstitution. Currently, little is known about the effect(s) that regulatory T cells may exert outside the immune system

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43

Koutrolos, Michail. "Role of regulatory T cells in experimental autoimmune encephalomyelitis." Diss., Ludwig-Maximilians-Universität München, 2013. http://nbn-resolving.de/urn:nbn:de:bvb:19-161896.

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44

Emani, Sirisha. "MOLECULAR CHARACTERIZATION OF T REGULATORY CELLS IN FIV-INFECTION." NCSU, 2006. http://www.lib.ncsu.edu/theses/available/etd-01192006-105756/.

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Naturally occurring CD4+CD25+ T regulatory cells (Treg) play important roles in maintaining immunologic self-tolerance in addition to controlling the magnitude of anti-microbial immune responses. However, the capacity of these CD4+CD25+ Treg cells to control immune responses both in vivo and in vitro is not well established. CD4+CD25+ Treg cell-mediated suppression can control autoimmune diseases; transplantation tolerance and graft verses host disease and, in contrast hinder tumor immunity and immunity to infectious agents. As Treg cells have been reported to be involved in several diseases,

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45

Stoop, Jeroen nicolaas. "Regulatory T cells in chronic hepatitis B virus infection." [S.l.] : Rotterdam : [The Author] ; Erasmus University [Host], 2007. http://hdl.handle.net/1765/11766.

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46

Oliveira, Vanessa A. G. de. "In vitro generation of CD4âº regulatory T cells." Thesis, University of Oxford, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.425944.

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47

Fernandas, Eduardo. "Development and application of allograft specific T regulatory cells." Thesis, Imperial College London, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.521125.

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48

Lindley, Shelley Maria. "Regulatory and effector T cells in type 1 diabetes." Thesis, King's College London (University of London), 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.430014.

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49

Carvalho, Thiago Lopes. "The role of regulatory CD4 T cells in inflammation." Tese, Porto : Edição do Autor, 2003. http://catalogo.up.pt/F?func=find-b&local_base=UPB01&find_code=SYS&request=000090835.

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50

Crittenden, Siobhan. "Regulation of intestinal regulatory T cells by prostaglandin E₂." Thesis, University of Edinburgh, 2018. http://hdl.handle.net/1842/33140.

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Pathogenesis of autoimmune and auto-inflammatory diseases is induced by auto-aggressive helper T (Th) cells (i.e. Th1 and Th17 cells), and can be controlled by regulatory T cells (Tregs) characterized by expression of the transcription factor Foxp3. Thus, development of autoimmunity is regulated by the balance of Tregs and Th1/Th17 cells. Prostaglandin E₂ (PGE₂) is a bioactive lipid mediator with immune-modulatory potential that acts through 4 receptors (EP1-4). It has been shown that PGE₂ facilitates Th1 and Th17 cell development and expansion, therefore promoting autoimmune inflammation. How

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