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Journal articles on the topic 'Reinke crystals'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Schmidt, Waldemar A. "Eosin-Induced Fluorescence of Reinke Crystals." International Journal of Gynecological Pathology 5, no. 1 (1986): 88–89. http://dx.doi.org/10.1097/00004347-198603000-00010.

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2

Mesa, Hector, Scott Gilles, Sophia Smith, Susan Dachel, Wendy Larson, and J. Carlos Manivel. "The mystery of the vanishing Reinke crystals." Human Pathology 46, no. 4 (2015): 600–606. http://dx.doi.org/10.1016/j.humpath.2015.01.004.

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3

Hribar, Kambridge P., Nancy E. Warner, and Andy E. Sherrod. "Cytologic Identification of Reinke Crystalloids in Scrapings and Imprints of Fresh Testicular Tumors: A Simple and Rapid Technique for Intraoperative Use." Archives of Pathology & Laboratory Medicine 129, no. 3 (2005): e65-e66. http://dx.doi.org/10.5858/2005-129-e65-ciorci.

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Abstract Although not required for the diagnosis, crystalloids of Reinke are pathognomonic for Leydig cell tumor. However, conventional frozen section rarely reveals their presence. A method of rapid identification of crystalloids of Reinke could improve the intraoperative diagnosis. We tested the efficacy of touch imprints and scrape smears for the identification of crystalloids in 2 cases of Leydig cell tumor of the testis. Intraoperative smears of the tumors yielded abundant crystals. Scrape cytologic testing was the better method. We speculate that the process of scraping, and to a lesser

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4

Kozina, Viviana, Ljerka Banek, Nikola Knežević, et al. "Reinke´s Crystals in Perivascular and Peritubular Leydig Cells." Croatica Chemica Acta 84, no. 2 (2011): 159–67. http://dx.doi.org/10.5562/cca1814.

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5

Al-Agha, Osama M., and Constantine A. Axiotis. "An In-Depth Look at Leydig Cell Tumor of the Testis." Archives of Pathology & Laboratory Medicine 131, no. 2 (2007): 311–17. http://dx.doi.org/10.5858/2007-131-311-ailalc.

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Abstract Leydig cell tumor (LCT) is a rare tumor of the male testicular interstitium. This article provides an overview of the major pathologic manifestations of LCT of the testis; patient characteristics; clinical, radiologic, and laboratory features; prognosis; and management. LCTs of the testis are frequently hormonally active, leading to either feminizing or virilizing syndromes. The tumor is usually benign, but malignant variants can occur. The pathologic diagnosis of LCT is usually made based on morphologic characteristics of the tumor cells. The significance of Reinke crystals in the di

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6

Mesa, Hector, Scott Gilles, Milton W. Datta, et al. "Immunophenotypic differences between neoplastic and non-neoplastic androgen-producing cells containing and lacking Reinke crystals." Virchows Archiv 469, no. 6 (2016): 679–86. http://dx.doi.org/10.1007/s00428-016-2028-4.

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7

LUQUE CUBA, Edith Jacqueline, Freddy GARCIA RAMOS, Adolfo RECHKEMMER PRIETO, et al. "Tumor de células esteroideas de ovario: Reporte de un caso." Revista Medica Herediana 16, no. 1 (2012): 80. http://dx.doi.org/10.20453/rmh.v16i1.867.

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The suggestive clinical characteristics of hyperandrogenism are very common problems in women and have been related with excessive androgen production from ovaries, suprarenal glands or both. The most common identifiable cause of androgen excess is the polycystic ovary syndrome. The virilizing tumors are rare. We report the case of a postmenopausal women with virilizing signs and a left anexial mass. Testosterone 4.3ng/mL (0.2-0.95); DHEAS 56ug/dL (35-430); androstenedione: 10ng/ml (0.4-2.7); Cortisol 16ug/dL. Testosterone post dexamethasone suppression test 3.5ng/mL. Ovarian steroid cell tumo

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8

Stetsuk, Ye V., V. I. Shepitko, O. M. Pronina, et al. "Effect of quercetin administration on electron microscopic changes in testicular interstitial endocrinocytes during long-term central blockade of luteinising hormone in rats." Reports of Morphology 30, no. 1 (2024): 68–75. http://dx.doi.org/10.31393/morphology-journal-2024-30(1)-09.

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Quercetin is a flavonoid with potential health benefits and it may help prevent cardiovascular diseases, reduce the risk of degenerative brain processes and cancer, and has antioxidant properties that neutralise free radicals. Substances in this group also have antioxidant properties, which help the body protect itself from the harmful effects of free radicals by neutralising these unstable molecules. Research indicates that the impact of free radicals on cell structure is associated with the development of chronic diseases such as diabetes, cancer, and cardiovascular pathologies. The aim of t

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9

Balaji, S., Nortan Stephen, Gowndanay, and Hiremalth. "Stromal luteoma in a case of multiple leiomyomatosis – A rare case report." IP Journal of Diagnostic Pathology and Oncology 7, no. 1 (2022): 43–45. http://dx.doi.org/10.18231/j.jdpo.2022.008.

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Stromal luteoma of the ovary occurs mostly in postmenopausal females and is very rare. They account for 60% Abnormal vaginal bleeding is the most frequent presentation, but endocrine symptoms and sometimes virilizing signs may also be observed. This tumour is a close mimicker of Leydig cell tumour. However, the stromal location and the absence of Reinke’s crystalloids helps to confirm the diagnosis. This tumour is surrounded by an ovarian stroma, entirely composed of luteinized cells devoid of crystals of Reinke. We report an unusual case of a 41 year old female who presented with abdominal pa

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10

Bouzidi, Lobna, Meriam Triki, Slim Charfi, et al. "Incidental Finding of Bilateral Ovarian Adrenal Rest Tumor in a Patient With Congenital Adrenal Hyperplasia: A Case Report and Brief Review." Pediatric and Developmental Pathology 24, no. 2 (2021): 137–41. http://dx.doi.org/10.1177/1093526620980614.

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Ovarian adrenal rest tumors (OART) are tumors that develop in females with congenital adrenal hyperplasia (CAH). In contrast to their counterpart in testicles, they are exceptional and few cases have been reported in the literature. In this report, we present clinicopathological findings of a female patient with CAH due to 21-hydroxylase deficiency who was incidentally diagnosed with OART with a review of the literature. The 14-year-old patient, who was raised as a boy, developed a virilizing syndrome with high testosterone levels that were attributed to non adherence to her replacement cortic

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11

JOHNSON, L., J. S. GRUMBLES, S. CHASTAIN, H. F. GOSS, and C. S. PETTY. "Leydig Cell Cytoplasmic Content Is Related to Daily Sperm Production in Men." Journal of Andrology 11, no. 2 (1990): 155–60. http://dx.doi.org/10.1002/j.1939-4640.1990.tb01595.x.

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The relationship between the abundance of specific Leydig cell organelles and daily sperm production (DSP) was determined. Testes from 10 men (26–53 years of age) were obtained at autopsy within 10 h of traumatic death or heart failure and fixed by vascular perfusion. Testicular tissue was processed for light and electron microscopy. DSP/testis and Leydig cell cytoplasmic volume/testis were determined by stereology of histologic sections. The Leydig cell organelle content was determined by point counting electron micrographs for smooth endoplasmic reticulum (SER), rough endoplasmic reticulum,

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12

Thakur, Dr Himani. "Malignant Leydig Cell Tumor of Testis: Case Report." Journal of Medical Science and clinical Research 12, no. 05 (2024): 01–04. http://dx.doi.org/10.18535/jmscr/v12i05.01.

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Testicular tumors accounts for % of the tumors in men. 5% of which are the sex cord stromal tumors and the remaining are of germ cell origin. Leydig cell are the common subtype of Sex cord stromal tumors and accounts for 1%-2% of all the testicular tumors. Tumor arises from the leydig cells that normally reside in the interstitium of testicles and secrete testosterone in the presence of leutenizing hormone. They show a bimodal distribution with peaks in the prepubertal age group and between 30-60yrs of age. Leydig cell tumor being a hormonally active tumor often presents with precocious pubert

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13

Saxena, Rushali, Smita Singh, and Kiran Agarwal. "Steroid Cell Tumor NOS and Xanthogranulomatous Oophoritis: A Rare Association Mimicking Ovarian Malignancy." Annals of Pathology and Laboratory Medicine 10, no. 8 (2023): C126–131. http://dx.doi.org/10.21276/apalm.3272.

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Steroid cell tumor, NOS is an infrequently reported ovarian tumor, rarely presenting without endocrine symptoms. Xanthogranulomatous inflammation of ovaries is an extremely rare finding which often mimics malignancy on imaging. This case report presents a unique co-incidental finding of these two rare entities as incidental findings. A 44 year old female with previous history of total abdominal hysterectomy for leiomyoma presented with abdominal discomfort. Clinical examination revealed bilateral adnexal mass. Imaging suggested a possibility of bilateral ovarian mucinous cystadenocarcinoma. CE

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14

Stetsuk, Ye V., V. I. Shepitko, N. V. Boruta, O. V. Vilkhova, T. A. Skotarenko, and M. V. Rud. "Electron microscopic changes in interstitial endocrinocytes of rats testicles during administration of triptorellin for 365 days." Reports of Morphology 29, no. 4 (2023): 64–69. http://dx.doi.org/10.31393/morphology-journal-2023-29(4)-09.

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Triptorelin is a gonadotropin-releasing hormone agonist that is a potent inhibitor of testosterone (in men) and estrogen (in women) synthesis and is used to treat advanced prostate cancer. Studies of the mechanisms of regulation and synthesis of testosterone formation in testicular interstitial cells demonstrate multiple endogenous targets that can increase testosterone biosynthesis, which may moderate the effects of testosterone depletion. Triptorelin, a synthetic analog of the neurohormone gonadoliberin, suppresses the expression of the GnRH receptor in the pituitary gland, but does not chan

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15

Kus, Deniz, and Bea Schumann. "Nakajima quiver varieties, affine crystals and combinatorics of Auslander-Reiten quivers." Algebra and Discrete Mathematics 34, no. 2 (2022): 244–72. http://dx.doi.org/10.12958/adm1952.

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We obtain an explicit crystal isomorphism between two realizations of crystal bases of finite dimensional irreducible representations of simple Lie algebras of type A and D. The first realization we consider is a geometric construction in terms of irreducible components of certain Nakajima quiver varieties established by Saito and the second is a realization in terms of isomorphism classes of quiver representations obtained by Reineke. We give a homological description of the irreducible components of Lusztig's quiver varieties which correspond to the crystal of a finite dimensional representa

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16

Kotula, Piotr. "Stibnite vein from Dębowina near Bardo (polish Sudetes)." Contemporary Trends in Geoscience 2, no. 1 (2013): 28–33. http://dx.doi.org/10.2478/ctg-2014-0004.

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Abstract In the contact zone of the Bardo Structure and Kłodzko-Złoty Stok Intrusion and Kłodzko Metamorphic, metasomatic orebearing quartz-carbonate veins rich in Sb, Zn, Cu, Ag, Au, Pb are present. In 1771 the mine ,,Reiche Silber Gluck” within stibnite vein was founded in Dębowina near Bardo. Its entrance was discovered again in 2007. The stibnite vein is mainly build of stibnite and sphalerite and of quartz and dolomite rich in Mn. Stibnite crystallizes as columnar or forming radiate centres and aciculars. Its crystals reach size to 2 mm. Sphalerite appears as individual anhedral and polym

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17

Soerensen, Rikke R., Trine H. Johannsen, Niels E. Skakkebaek, and Ewa Rajpert-De Meyts. "Leydig cell clustering and Reinke crystal distribution in relation to hormonal function in adult patients with testicular dysgenesis syndrome (TDS) including cryptorchidism." HORMONES 15, no. 4 (2017): 518–26. http://dx.doi.org/10.14310/horm.2002.1708.

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18

Wendorff, Marco, and Caroline Röhr. "Neue Erdalkalimetall-reiche binäre Indide: Ca2In, Sr28In11 und Sr5In3 / New Alkaline Earth Rich Binary Indides: Ca2In, Sr28In11 und Sr5In3." Zeitschrift für Naturforschung B 59, no. 6 (2004): 619–28. http://dx.doi.org/10.1515/znb-2004-0601.

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The new binary alkaline earth rich indides Ca2In (orthorhombic, space group Pnma, a =727.5(2), b = 537.1(2), c = 999.0(3) pm, Z = 4, R1 = 0.0252, Co2Si structure type) and Sr28In11 (orthorhombic, space group Imm2, a=582.6(3), b=6687.8(9), c=823.5(6) pm, Z =2, R1=0.0571, Ca28Ga11 structure type) have been synthesized from stoichiometric melts of the elements. Both crystal structures exhibit isolated In atoms coordinated by seven to ten alkaline earth atoms. In the crystal structure of Sr5In3 (tetragonal, space group I4/mcm, a = 874.4(3), c = 1642.9(8) pm, Z = 4, R1 = 0.0347, Cr5B3 structure typ

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19

Wendorff, Marco, and Caroline Röhr. "Zink-reiche Erdalkalimetall-Verbindungen AZn5 und AZn11: Kristallstrukturen und chemische Bindung / Zinc-rich Alkaline Earth Compounds AZn5 and AZn11: Crystal Structures and Chemical Bonding." Zeitschrift für Naturforschung B 62, no. 12 (2007): 1549–62. http://dx.doi.org/10.1515/znb-2007-1213.

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The zinc-rich compounds in the binary systems with the heavier alkaline earth elements CaZn11 and AZn5 (A = Ca, Sr, Ba) have been synthesized from melts of the elements. Their crystal structures, which were in principle known from very early powder or single crystal film experiments, have been refined on the basis of modern single crystal X-ray data. CaZn5 (hexagonal, space group P6/mmm, a = 538.99(2), c = 424.56(1) pm, Z = 1, R1 = 0.0144) crystallizes with the CaCu5 structure type and exhibits a small but distinct phase width Ca1−xZn5+2x up to a composition of Ca0.87Zn5.26 (a = 533.38(1), c =

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20

Wendorff, Marco, and Caroline Röhr. "Neue gemischte Zinn-reiche Erdalkalimetall-Stannide – Synthese, Strukturchemie und chemische Bindung / New Mixed Tin-rich Alkaline Earth Stannides – Synthesis, Structural Chemistry and Chemical Bonding." Zeitschrift für Naturforschung B 66, no. 3 (2011): 245–61. http://dx.doi.org/10.1515/znb-2011-0306.

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Ternary mixed Ca/Ba-Sr pentastannides AIISn5 (AII = Ca, Sr, Ba) have been synthesized from stoichiometric mixtures of the elements or from tin-rich melts. The crystal structures of two new compounds of overall composition ASn5 (A = Sr, Ba) were determined by means of single-crystal X-ray data. The structures of both Sr0.94Ba0.06Sn5 (monoclinic, space group C2/m, a = 1762.8(11), b = 704.1(3), c = 1986(2) pm, β = 100.31(6)º, Z = 14, R1 = 0.0996) and Sr0.89Ba0.11Sn5 (orthorhombic, space group Cmcm, a = 708.1(2), b = 1770.4(8), c = 2781.6(11) pm, Z = 20 , R1 = 0.0821) are closely related and can b

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21

Dockal, Michael, Rudolf Hartmann, Thomas Polakowski, et al. "Molecular Characterization of the Synergistic Effect on TFPI Inhibition By Fusion of Two Inhibitory Peptides." Blood 124, no. 21 (2014): 1484. http://dx.doi.org/10.1182/blood.v124.21.1484.1484.

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Abstract Introduction Tissue factor pathway inhibitor (TFPI) is a three-Kunitz domain (KD1-3) protease inhibitor that downregulates the extrinsic coagulation pathway. TFPI has a double inhibitory effect; it inactivates factor Xa (FXa) by 1:1 binding via its KD2, and it prevents further FX activation by binding the tissue factor (TF) – factor VIIa (FVIIa) complex via its KD1 and the formation of a quaternary complex. Recently, we demonstrated the crystal structure of a linear TFPI inhibitory peptide composed of 20 amino acids, bound to a TFPI protein composed of N-terminus and KD1. On the other

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22

Planinić, Ana, Tihana Marić, Ana Katušić Bojanac, and Davor Ježek. "Reinke crystals: Hallmarks of adult Leydig cells in humans." Andrology, June 4, 2022. http://dx.doi.org/10.1111/andr.13201.

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23

Mesa, H., S. Gilles, S. Smith, S. Dachel, W. Larson, and JC Manivel. "10.1016/j.humpath.2015.01.004." January 15, 2015. https://doi.org/10.5281/zenodo.894670.

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Reinke crystals (RC) are pathognomonic of Leydig cells (LCs); they are thought to be rare in normal testes and to occur only in approximately one third of LC tumors. We noticed that crystals present in touch imprint and frozen sections of an LC tumor disappeared after tissue fixation. This phenomenon led us to hypothesize that their reported low frequency in normal and neoplastic LCs may be secondary to degradation/dissolution of the crystals after formalin fixation. Our review of the literature also led us to hypothesize that RC are better preserved after air-drying and alcohol fixation. We c

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24

Mesa, H., S. Gilles, MW Datta, et al. "Immunophenotypic differences between neoplastic and non-neoplastic androgen-producing cells containing and lacking Reinke crystals." October 1, 2016. https://doi.org/10.1007/s00428-016-2028-4.

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We performed a detailed morphologic, immunophenotypic, and endocrine characterization of neoplastic and non-neoplastic lesions of androgen-producing cells known to harbor or lack Reinke crystals (RCs) with an aim to provide further insight into the nature of these cells and crystals. Study cases were selected from the files of participating hospitals and subclassified according to current classifications: 20 with Leydig cell tumors (LCTs), 2 with testicular adrenal rest tumors (TARTs), 2 with testicular tumors of adrenogenital syndrome (TTAGS), and 2 with androgen insensitivity syndrome (AIS).

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25

Mon Myint, Myat Su, and Antonio Pinero-Pilona. "THU643 Hyperandrogenism Caused By A Steroid Cell Tumor Of The Ovary In A Postmenopausal Woman." Journal of the Endocrine Society 7, Supplement_1 (2023). http://dx.doi.org/10.1210/jendso/bvad114.1547.

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Abstract Disclosure: M.S. Myint: None. A. Pinero-Pilona: None. Introduction Steroid cell tumor-not otherwise specified (SCT-NOS) is a subtype of steroid cell tumors which, in turn, is a subtype of sex cord-stroma tumors of the ovary. SCTs are exceedingly rare, account for less than 0.1% of all ovarian tumors, can secrete androstenedione, α-hydroxyprogesterone, and testosterone, and cause hyperandrogenism. We present a case of SCT-NOS, which was revealed postoperatively and was associated with breast cancer. Clinical Case A 74-year-old postmenopausal woman presented approximately a year after t

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