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Mallick, Bibekanand, Jayprokas Chakrabarti, and Zhumur Ghosh. "MicroRNA reins in embryonic and cancer stem cells." RNA Biology 8, no. 3 (2011): 415–26. http://dx.doi.org/10.4161/rna.8.3.14497.
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Yousef, George, and Eleftherios Diamandis. "Tissue kallikreins: new players in normal and abnormal cell growth?" Thrombosis and Haemostasis 90, no. 07 (2003): 7–16. http://dx.doi.org/10.1055/s-0037-1613593.
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SummarySerine proteases are proteolytic enzymes with an active serine residue in their catalytic site. Kallikreins are a subgroup of the serine protease family and are known to have diverse physiological functions. The human tissue kallikrein gene family has now been fully characterized and includes 15 members, clustered in a 300 kb region on chromosome 19q13.4. In this review, we discuss the common structural features of kallik-reins at the DNA, mRNA and protein levels. Kallikreins are secreted as inactive zymogens and are activated by cleavage of an N-terminal peptide. Some kallikreins can undergo autoactivation while others may be activated by other kallikreins or other proteases. Most kallikreins are predicted to have trypsin-like enzymatic activity except for three members which may have chymotrypsin-like activity. Circumstantial evidence suggests that at least some kallikreins may be part of an enzymatic cascade pathway which is activated in aggressive forms of ovarian and probably other cancers. Accumulating evidence suggests potential diagnostic and/or prognostic roles of kallikreins in diverse malignancies. In addition to PSA, many other kallik-reins show differential expression in malignancy. For example, hK6, 10 and 11 are promising serological markers for ovarian cancer diagnosis. KLK10 may act as a tumor suppressor. In addition to their diagnostic and prognostic values, kallikreins may also be good therapeutic targets.Part of this paper was originally presented at the joint meetings of the 16th International Congress of the International Society of Fibrinolysis and Proteolysis (ISFP) and the 17th International Fibrinogen Workshop of the International Fibrinogen Research Society (IFRS) held in Munich, Germany, September, 2002.
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Fenoglietto, P., S. Vieillot, C. Llacer Moscardo, J. B. Dubois, and D. Azria. "Préservation des deux reins dans le cas de traitements de cancer abdominaux avec RapidArc®." Cancer/Radiothérapie 15, no. 6-7 (2011): 598–99. http://dx.doi.org/10.1016/j.canrad.2011.07.110.
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Wolters, Pamela L., Ana-Maria Vranceanu, Heather L. Thompson, et al. "Current Recommendations for Patient-Reported Outcome Measures Assessing Domains of Quality of Life in Neurofibromatosis Clinical Trials." Neurology 97, no. 7 Supplement 1 (2021): S50—S63. http://dx.doi.org/10.1212/wnl.0000000000012421.
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ObjectiveTo review and recommend patient-reported outcome (PRO) measures assessing multidimensional domains of quality of life (QoL) to use as clinical endpoints in medical and psychosocial trials for children and adults with neurofibromatosis (NF) type 1, NF2, and schwannomatosis.MethodsThe PRO working group of the Response Evaluation in Neurofibromatosis and Schwannomatosis (REiNS) International Collaboration used systematic methods to review, rate, and recommend existing self-report and parent-report PRO measures of generic and disease-specific QoL for NF clinical trials. Recommendations were based on 4 main criteria: patient characteristics, item content, psychometric properties, and feasibility.ResultsThe highest-rated generic measures were (1) the Pediatric Quality of Life Inventory (PedsQL) Generic Core Scales for NF clinical trials for children or for children through adults, (2) the Functional Assessment of Cancer Therapy–General for adult medical trials, and (3) the World Health Organization Quality of Life–BREF for adult psychosocial trials. The highest-rated disease-specific measures were (1) the PedsQL NF1 Module for NF1 trials, (2) the NF2 Impact on Quality of Life Scale for NF2 trials, and (3) the Penn Acoustic Neuroma Quality of Life Scale for NF2 trials targeting vestibular schwannomas. To date, there are no disease-specific tools assessing multidimensional domains of QoL for schwannomatosis.ConclusionsThe REiNS Collaboration currently recommends these generic and disease-specific PRO measures to assess multidimensional domains of QoL for NF clinical trials. Additional research is needed to further evaluate the use of these measures in both medical and psychosocial trials.
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Clayton, H. M., B. Smith, and A. Egenvall. "Rein tension in novice riders when riding a horse simulator." Comparative Exercise Physiology 13, no. 4 (2017): 237–42. http://dx.doi.org/10.3920/cep170010.
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This study reports tension in the left and right reins when riding a horse simulator that moved only in the sagittal plane. The objective was to determine whether asymmetries in rein tension of novice riders at the rising trot, canter, and halt were present, and if so, to investigate their relationship with the rider’s handedness. The experimental hypothesis was that rein tension would be higher on the side of the rider’s non-dominant hand. 22 novice riders (19 right-handed; 3 left-handed) rode a horse simulator at halt, rising trot and canter. Rein tension was recorded in both reins at a sampling rate of 1000 Hz for 8 s at each gait. The variables measured in rising trot and canter were minimal and maximal tension, the change between minimal and maximal values and mean tension per step at rising trot or per stride at canter. At halt only mean tension during the 8 s recording was measured. Comparisons between right and left reins and between right-handed and left-handed riders were made using mixed models. The results showed no asymmetries in mean tension at halt. In rising trot and canter all significant differences involved higher tension in the right rein regardless of handedness of the riders. During rising trot the minimum was higher in the right rein over all riders and both the mean and maximal values were higher in the right rein in left-handed riders. In canter left-handed riders had higher mean tension in the right rein. All recorded asymmetries had higher tension in the right rein compared with the left and they were more prevalent in left-handed riders which implies higher tension in the non-dominant hand. Rein tension patterns were not symmetrical on the left and right sides and asymmetries in left-handed riders were not mirrored in right-handed riders.
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Clayton, Hilary M., Wesley H. Singleton, Joel L. Lanovaz, and Gary L. Cloud. "Strain gauge measurement of rein tension during riding: a pilot study." Equine and Comparative Exercise Physiology 2, no. 3 (2005): 203–5. http://dx.doi.org/10.1079/ecp200553.
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AbstractA pilot study was performed using a strain gauge transducer intercalated between the bit and the left rein to measure rein tension dynamically during riding. The strain patterns consisted of a series of spikes with frequencies corresponding to two per stride in walk and trot and one per stride in canter. The highest tension recorded in each gait was 43 N at walk, 51 N at trot and 104 N in canter. Based on the results of this study, it is recommended that the methodology should be adapted so that both reins are instrumented simultaneously, data are transmitted telemetrically to eliminate the need for a tether connecting the horse to the computer, and kinematic data are synchronized with the rein tension recordings.
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Piccolo, Lara, and Kathrin Kienapfel. "Voluntary Rein Tension in Horses When Moving Unridden in a Dressage Frame Compared with Ridden Tests of the Same Horses—A Pilot Study." Animals 9, no. 6 (2019): 321. http://dx.doi.org/10.3390/ani9060321.
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Too much rein tension while riding may compromise the welfare of the horse. But who generates the tension on the reins—the horse or the rider? The primary aim of this pilot study was to evaluate the maximum rein tension that horses voluntarily maintain without a rider compared to rein tension with a rider. A secondary aim was to evaluate conflict behaviours in relation to rein tension. Thirteen horses were used, all fitted with customised “Animon” rein tension sensors (25 Hz, up to 600 N range), free-moving with side reins set in dressage competition frame with the noseline on the vertical. Rein tension was measured at the walk, trot, and canter in both directions in a round pen. The same horses were then ridden by their usual riders and completed the same task on a riding ground. Continuous video recordings were obtained to subsequently quantify the occurrence of conflict behaviours. The difference in mean maximum peak of rein tension with and without a rider for each gait was compared using the Wilcoxon Rank Sum test. Without a rider, rein tension was significantly lower (Wilcoxon T = 0, p < 0.01, 7.5 N ± 2.8 N) than with a rider (Wilcoxon T = 0, p < 0.01, 24.0 N ± 12.3 N). Regardless of the different rein tensions in the ridden exercise, all of the horses exhibited approximately the same amount of rein tension in the unridden exercise. The frequency of conflict behaviour was higher with a rider than without (11 ± 14 per minute vs. 2 ± 3 per minute; T = 4, p < 0.01).
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Egenvall, A., M. Eisersiö, M. Rhodin, R. van Weeren, and L. Roepstorff. "Rein tension during canter." Comparative Exercise Physiology 11, no. 2 (2015): 107–17. http://dx.doi.org/10.3920/cep150005.
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Riders generally use reins as a means for communication with the horse. At present, the signalling pattern is poorly understood. The aim of this study was to illustrate and analyse the rein tension patterns in a number of rider/horse combinations across a variety of exercises in the canter gait. Our hypothesis was that some riders will follow the movement of the horse more closely than others. Data were collected from eight professional riders riding each three (in one case two) horses that were familiar to them in canter. Horses were instrumented with rein tension meters logged by inertial measurement unit technique (IMU). Inside and outside rein tension data were synchronised with the gait using the vertical acceleration IMU-signal at the poll. Stride-split data (0-100 percentages) were analysed using mixed models technique to elucidate the inside/outside and stride percentage interaction, taking into account the exercises performed. In general, tension was maximal just before the beginning of vertical stance, as defined by the maximal acceleration of the head, with the release closer to the suspension phase. The release was significantly more marked on the outside rein, but between riders and horses the pattern varied substantially. In total 26% of the variation was represented by riders and 21% by the horses. On average there were significant inside/outside rein differences, but at the same time in some horse/rider combinations these differences did not exist.
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Kachuri, L., P. De, LF Ellison, and R. Semenciw. "Tendances concernant l'incidence du cancer, la mortalité par cancer et la survie au cancer au Canada entre 1970 et 2007." Maladies chroniques et blessures au Canada 33, no. 2 (2013): 80–92. http://dx.doi.org/10.24095/hpcdp.33.2.03f.
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Introduction La surveillance des tendances concernant le cancer peut aider à évaluer les progrès réalisés dans la lutte contre le cancer ainsi qu'à renforcer les activités de prévention. La présente étude, fondée sur les données des bases de données nationales, consiste en un examen des tendances à long terme relatives à certains cancers au Canada. Méthodologie Nous avons examiné les changements annuels dans les tendances relatives aux taux d'incidence et de mortalité normalisés selon l'âge observés entre 1970 et 2007 selon le sexe pour tous les cancers combinés, pour les quatre cancers les plus courants (cancer de la prostate, cancer du sein, cancer du poumon, cancer colorectal) et pour les cancers dont les tendances ont été marquées par les changements les plus importants au cours des dernières années. Le rapport de survie relative à cinq ans pour les années 1992 à 2007 a également été calculé. Résultats Pendant la période visée par l'étude, les taux d'incidence de l'ensemble des cas de cancer primitif combinés ont augmenté de 0,9 % par année chez les hommes et de 0,8 % par année chez les femmes. Les taux concernant le mélanome, le cancer de la thyroïde, le cancer du foie, le cancer de la prostate, le cancer du rein, le cancer colorectal, le cancer du poumon, le cancer du sein et le cancer de la vessie ont augmenté à des rythmes variables, et les taux concernant le cancer du larynx, le cancer de la bouche, le cancer de l'estomac et le cancer du col de l'utérus ont diminué. Pour l'ensemble des cancers combinés et pour la plupart des cancers examinés, à l'exception du mélanome et du cancer du poumon chez les femmes, les taux de mortalité ont diminué significativement. Les taux de survie qui ont le plus augmenté sont ceux du cancer de la prostate, du cancer du foie, du cancer colorectal et du cancer du rein. Bien que les tendances globales concernant les taux de mortalité et la survie indiquent que des progrès notables ont été réalisés dans la lutte contre le cancer, la tendance à la hausse des taux d'incidence de certains cancers soulignent la nécessité de poursuivre les efforts dans le domaine de la prévention.
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Zakaria, Dianne, and Amanda Shaw. "Cancers attribuables à l’excès de poids au Canada en 2010." Promotion de la santé et prévention des maladies chroniques au Canada 37, no. 7 (2017): 223–34. http://dx.doi.org/10.24095/hpcdp.37.7.01f.
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Introduction L’excès de poids (indice de masse corporelle [IMC] de 25,00 kg/m2 ou plus) est un facteur de risque bien connu de diabète, d’hypertension et de maladie cardiovasculaire, mais on en sait moins sur son lien avec le cancer. Dans cette étude, nous avons utilisé le risque attribuable dans la population (RAP) pour estimer le fardeau des cancers attribuables à l’excès de poids chez les adultes canadiens (de 25 ans ou plus) en 2010. Méthodologie Nous avons estimé les RAP en utilisant des estimations du risque relatif (RR) tirées du Continuous Update Project du World Cancer Research Fund International, des estimations du surpoids et de l’obésité fondées sur l’IMC tirées de l’Enquête sur la santé dans les collectivités canadiennes de 2000-2001 (surpoids : 25,00 à 29,99 kg/m2; obésité : 30,00 kg/m2 et plus) et nous avons utilisé les nombres de cas de cancer figurant dans le Registre canadien du cancer. Les RAP ont été fondés sur des IMC corrigés pour tenir compte du biais associé à l’autodéclaration de la taille et du poids. Résultats Au Canada, en 2010, on peut attribuer environ 9 645 cas de cancer à un excès de poids, ce qui représente 5,7 % de tous les cas de cancer (hommes : 4,9 %; femmes : 6,5 %). En limitant l’analyse aux types de cancer associés à un IMC élevé, le RAP augmente à 14,9 % (hommes : 17,5 %; femmes : 13,3 %). Les types de cancer pour lesquels le RAP était le plus élevé étaient l’adénocarcinome de l’oesophage (42,2 %), le cancer du rein (25,4 %), le cancer du cardia (20,7 %), le cancer du foie (20,5 %), le cancer du côlon (20,5 %) et le cancer de la vésicule biliaire (20,2 %) chez les hommes, et l’adénocarcinome de l’oesophage (36,1 %), le cancer de l’utérus (35,2 %), le cancer de la vésicule biliaire (23,7 %) et le cancer du rein (23,0 %) chez les femmes. Les types de cancer pour lesquels le nombre de cas attribuables était le plus élevé étaient le cancer du côlon (1 445), le cancer du rein (780) et le cancer de la prostate à un stade avancé (515) chez les hommes, et le cancer de l’utérus (1 825), le cancer du sein postménopausique (1 765) et le cancer du côlon (675) chez les femmes. Quels que soient le sexe et le type de cancer, les RAP étaient les plus élevés dans les Prairies (sauf en Alberta) et la région de l’Atlantique, et les plus faibles en Colombie-Britannique et au Québec. Conclusion Le fardeau du cancer attribuable à l’excès de poids est considérable et continuera de croître à court terme en raison de la hausse de la prévalence du surpoids et de l’obésité au Canada.
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Lance, Peter. "Colorectal Cancer Screening: Confusion Reigns." Cancer Epidemiology Biomarkers & Prevention 17, no. 9 (2008): 2205–7. http://dx.doi.org/10.1158/1055-9965.epi-08-0688.
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Birmingham, Karen. "Confusion reigns over breast cancer." Nature Medicine 7, no. 12 (2001): 1266. http://dx.doi.org/10.1038/nm1201-1266b.
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Mason, Sam, Eftychios Manoli, Liam Poynter, et al. "Mass spectrometry transanal minimally invasive surgery (MS-TAMIS) to promote organ preservation in rectal cancer." Surgical Endoscopy 34, no. 8 (2019): 3618–25. http://dx.doi.org/10.1007/s00464-019-07140-y.
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Abstract Background Transanal minimally invasive surgery (TAMIS) is deployed for organ preservation in early rectal cancer and significant rectal polyps. Rapid evaporative ionisation mass spectrometry (REIMS) provides biochemical tissue analysis, which could be applied intraoperatively to give real-time tissue feedback to the surgeon and decrease the risk of an involved margin. However, the accuracy and feasibility of this approach have not been established. Methods In this prospective observational study, patients undergoing resection of rectal adenomas or carcinomas were recruited. An electrosurgical handpiece analysed tissues ex vivo using diathermy, with the aerosol aspirated into a Xevo G2-S ToF mass spectrometer. The relative abundance of lipids underwent predictive statistical modelling and leave-one-patient-out cross-validation. The outcomes of interest were the ability of REIMS to differentiate normal, adenomatous and cancerous tissue, or any disease subtype from normal. REIMS was coupled with TAMIS for in vivo sampling, assessing the accuracy of tissue recognition and distinguishing bowel wall layers. Results Forty-seven patients were included, yielding 266 spectra (121 normal, 109 tumour and 36 adenoma). REIMS differentiates normal, adenomatous and cancerous rectal tissues with 86.8% accuracy, and normal and adenomatous tissue with 92.4% accuracy and 91.4% accuracy when differentiating disease from normal. We have performed the first five in-man mass spectrometry augmented TAMIS (MS-TAMIS). In real time, MS-TAMIS can differentiate rectal mucosa and submucosa based on their relative abundance of triglycerides and glycerophospholipids. The ex vivo accuracy distinguishing diseased and normal tissues is maintained in vivo at 90%, with negative predictive value of 95%. The system identified a deep and lateral involved tumour margin during TAMIS. Conclusions REIMS distinguishes rectal tissue types based on underlying lipid biology, and this can be translated in vivo by coupling it to TAMIS. There is a role for this technology in improving the efficacy of resection of early rectal cancers.
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Hafezi, Shirin A., and Wael M. Abdel-Rahman. "The Endocrine Disruptor Bisphenol A (BPA) Exerts a Wide Range of Effects in Carcinogenesis and Response to Therapy." Current Molecular Pharmacology 12, no. 3 (2019): 230–38. http://dx.doi.org/10.2174/1874467212666190306164507.
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Background: Bisphenol A (BPA) is a synthetic plasticizer that is commonly used in the production of polycarbonate plastics and epoxy resins. Human exposure occurs when BPA migrates from food and beverage containers into the contents when heated or even under normal conditions of use. BPA exerts endocrine disruptor action due to its weak binding affinity for the estrogen receptors ERα and ERβ. BPA exerts other effects by activating the membrane receptor GPER (GPR30) and/or other receptors such as the estrogen-related receptors (ERRs). Objective: This review summarizes emerging data on BPA and cancer. These include data linking exposure to BPA with an increased risk of hormone-related cancers such as those of the ovary, breast, prostate, and even colon cancer. BPA can also induce resistance to various chemotherapeutics such as doxorubicin, cisplatin, and vinblastine in vitro. The development of chemoresistance to available therapeutics is an emerging significant aspect of BPA toxicity because it worsens the prognosis of many tumors. Conclusion: Recent findings support a causal role of BPA at low levels in the development of cancers and in dictating their response to cytotoxic therapy. Accurate knowledge and consideration of these issues would be highly beneficial to cancer prevention and management.
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Mitra, D., A. K. Shaw, and K. Hutchings. "Évolution de l’incidence du cancer chez les enfants au Canada, 1992–2006." Maladies chroniques et blessures au Canada 32, no. 3 (2012): 147–55. http://dx.doi.org/10.24095/hpcdp.32.3.03f.
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Introduction Le cancer est la principale cause de décès lié à la maladie chez les enfants de 1 à 14 ans au Canada. Malgré l’importance pour la santé publique du cancer chez les enfants, peu de rapports évalués par des pairs ont été publiés sur l’évolution de la situation au Canada. La présente étude porte sur l’évolution des cas de cancer par âge, par sexe et par province de résidence, selon les plus récentes données sur les cancers enregistrés. Méthodologie Nous avons utilisé les données fondées sur la population du Registre canadien du cancer pour dégager les tendances de l’incidence des cancers primitifs diagnostiqués entre 1992 et 2006 chez les enfants (0-14 ans) pour les 12 grandes catégories de cancer de la Classification internationale du cancer chez les enfants, 3e édition (CICE-3). Résultats De 1992 à 2006, le taux d’incidence de tous les cancers confondus est demeuré stable, mais les tendances variaient selon le type de cancer. Nous avons observé chez les garçons une diminution significative des rétinoblastomes sur l’ensemble de la période à l’étude (− 6,5 % par année) ainsi qu’une augmentation des leucémies de 1992 à 1999 (+ 3,5 % par année). Chez les filles, nous avons constaté une diminution significative des tumeurs du rein de 1998 à 2006 (− 5,7 % par année) et une augmentation des tumeurs du foie de 1997 à 2006 (+ 8,1 % par année). Nous avons aussi relevé des différences en fonction de l’âge et de la province. Il faut interpréter avec prudence les tendances qui se rapportent à un faible nombre de cas par année ou qui présentent un large intervalle de confiance à 95 %. Conclusion Les résultats illustrent la nécessité d’une surveillance à l’échelle de la population et des besoins en recherche étiologique.
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Anstadt, George W. "Cancer and Coal Tar Epoxy Resins." Journal of Occupational and Environmental Medicine 31, no. 7 (1989): 582–83. http://dx.doi.org/10.1097/00043764-198907000-00005.
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Bouras, Samir. "Oncological outcomes of partial nephrectomy." Batna Journal of Medical Sciences (BJMS) 8, no. 1 (2021): 9–12. http://dx.doi.org/10.48087/bjmsoa.2021.8102.
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Introduction. Selon les données de l'Organisation mondiale de la santé 2018, le cancer du rein occupe en Algérie le 20eme rang chez les deux sexes. L'objectif de cette étude est d'évaluer nos résultats oncologiques de la néphrectomie partielle. Patients et méthodes. Étude rétrospective mono centrique, de juin 2012 à mars 2020. 50 patients ont bénéficié d'une néphrectomie partielle pour cancer du rein. Parmi ces patients, 37 (74%) cancer ont été confirmés par la pathologie. L'étude statistique a été réalisée à l'aide du logiciel SPSS 20. Résultats. L'âge moyen était de 55,1 ans et les femmes étaient majoritaires 23 (62,2%). Le carcinome à cellules claires prédominait : 21 cas (56,8%). Les marges chirurgicales étaient positives dans 06 cas (16,2%) et le stade pT1 était majoritaire dans 29 (78,3%). Après un suivi moyen de 55,7 mois, nous avons eu un taux de récidive global de 10,8% (04 patients). Aucun facteur de risque probable n’a été statistiquement significatif. Discussion. Nos résultats carcinologiques sont comparables aux données de la littérature (des taux de récidives jusqu’à 10,6%). Malgré un taux relativement élevé de marges chirurgicales positives, 80% des récidives sont survenus sur des marges négatives. En effet, les marges chirurgicales positives ne sont pas considérées comme un facteur de risque de récidive indépendant. Plusieurs facteurs de risque de récurrence ont été rapportés ; cependant dans cette série, nul n’a été identifié. Le cancer du rein est connu pour des récidives très tardives. Conclusion. La néphrectomie partielle est réalisée dans notre service depuis plus de 08 ans en toute sécurité, avec des résultats oncologiques satisfaisants. Mots clés : cancer du rein, néphrectomie partielle, résultats oncologiques.
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Murtola, Teemu Johannes, Kala Visvanathan, Miia Artama, Harri Vainio, and Eero Pukkala. "Breast cancer mortality among users of cholesterol-lowering drugs." Journal of Clinical Oncology 31, no. 15_suppl (2013): 1514. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.1514.
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1514 Background: Breast cancer is a common malignancy and cause of cancer death. Recent studies have suggested that statins, an established cholesterol-lowering drug group used in the prevention of cardiovascular mortality, could have beneficial effects against recurrence and progression of breast cancer. We evaluated breast cancer-specific mortality among users of statins and other cholesterol-lowering drugs (fibrates and bile-acid binding resins) in a cohort of breast cancer patients. Methods: Our study cohort included all newly diagnosed breast cancer patients in Finland during 1995-2003 (31,236 cases), identified from the Finnish Cancer Registry. Information on cholesterol-lowering medication use was obtained from a national prescription database.We used Cox proportional hazards regression method to estimate mortality among medication users. Results: A total of 4,169 participants had used statins, while 313 had used fibrates or resins. Despite similar median age, tumor and treatment characteristics, only statin use was associated with decreased breast cancer mortality (participants with localized tumors: HR 0.33, 95% CI 0.24-0.42; metastatic tumors: HR 0.52, 95% CI 0.31-0.86). Fibrate and resin use were associated with increased overall mortality (HR 1.70, 95% CI 0.96-2.99 for participants with localized disease, HR 2.65, 95% CI 1.18-5.96 for participants with metastatic disease). Conclusions: Decreased breast cancer mortality among users of statins, but not other cholesterol-lowering drugs despite similar population characteristics suggests that this drug group may have benefit in prevention of cancer progression. Clinical trials testing statins’ efficacy in breast cancer patients are warranted.
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Selenskas, Sandra, M. Jane Teta, and Joseph N. Vitale. "Pancreatic cancer among workers processing synthetic resins." American Journal of Industrial Medicine 28, no. 3 (1995): 385–98. http://dx.doi.org/10.1002/ajim.4700280308.
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Schmiech, Michael, Sophia J. Lang, Katharina Werner, Luay J. Rashan, Tatiana Syrovets, and Thomas Simmet. "Comparative Analysis of Pentacyclic Triterpenic Acid Compositions in Oleogum Resins of Different Boswellia Species and Their In Vitro Cytotoxicity against Treatment-Resistant Human Breast Cancer Cells." Molecules 24, no. 11 (2019): 2153. http://dx.doi.org/10.3390/molecules24112153.
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Pentacyclic triterpenic acids from oleogum resins of Boswellia species are of considerable therapeutic interest. Yet, their pharmaceutical development is hampered by uncertainties regarding botanical identification and the complexity of triterpenic acid mixtures. Here, a highly sensitive, selective, and accurate method for the simultaneous quantification of eight boswellic and lupeolic acids by high-performance liquid chromatography with tandem mass spectrometry detection (HPLC-MS/MS) was developed. The method was applied to the comparative analysis of 41 oleogum resins of the species B. sacra, B. dalzielli, B. papyrifera, B. serrata, B. carterii, B. neglecta, B. rivae, B. frereana, and B. occulta. Multivariate statistical analysis of the data revealed differences in the triterpenic acid composition that could be assigned to distinct Boswellia species and to their geographic growth location. Extracts of the oleogum resins exhibited cytotoxicity against the human, treatment-resistant, metastatic breast cancer cell line MDA-MB-231. Extracts from B. sacra were the most potent ones with an average IC50 of 8.3 ± 0.6 µg/mL. The oleogum resin of the B. sacra was further fractionated to enrich different groups of substances. The cytotoxic efficacy against the cancer cells correlates positively with the contents of pentacyclic triterpenic acids in Boswellia extracts.
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Kammerer-Jacquet, S. F., S. Thierry, and N. Rioux-Leclercq. "Cancers du rein : évolution de la classification anatomopathologique." Oncologie 20, no. 7-12 (2018): 193–98. http://dx.doi.org/10.3166/onco-2019-0025.
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Depuis la dernière classification OMS des tumeurs urogénitales en 2004, les progrès en pathologie moléculaire ont permis de démembrer un certain nombre de sous-types histologiques des tumeurs du rein avec des profils histologiques, phénotypiques et moléculaires différents. Cette revue a pour objectif de rappeler les dernières nouveautés concernant l’évolution de la classification OMS des tumeurs du rein et les facteurs pronostiques requis pour ces cancers.
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Miller, Carrie A., Jeanine P. D. Guidry, and Bernard F. Fuemmeler. "Breast Cancer Voices on Pinterest: Raising Awareness or Just an Inspirational Image?" Health Education & Behavior 46, no. 2_suppl (2019): 49S—58S. http://dx.doi.org/10.1177/1090198119863774.
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The public increasingly searches for and discusses health information online, but few studies have examined breast cancer–related posts on visual social media platforms. To shed light on cancer-focused posts on the visual social media platform Pinterest, this study analyzed a random sample of 476 breast cancer–related posts (also referred to as “pins”). Using a quantitative content analysis, pins were coded for type of visual and textual information included and user engagement with pins (i.e., frequency of repins and comments). This novel research supports the current use and potential future utility of Pinterest as a venue for health communication related to breast cancer. Study results have important implications for the development of future health promotion programs on Pinterest aimed at reducing breast cancer risk among women.
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Gundu Venkata Surya, Ashok Kumar, Jayagopal Vithya, Senthilvadivu Rajarajan, and Ramalingam Kumar. "Purification of 89Sr from FBTR irradiated Yttria target by extraction chromatography using HDEHP impregnated XAD-7 resin." Radiochimica Acta 109, no. 3 (2021): 215–23. http://dx.doi.org/10.1515/ract-2020-0075.
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Abstract 89Sr is used in bone pain palliative care of cancer patients and the same is being produced presently via the 89Y(n, p)89Sr reaction by irradiating yttria target in Fast Breeder Test Reactor (FBTR). An efficient separation method was standardized for the removal of bulk yttrium target by extraction chromatography using di(2-ethylhexyl) phosphoric acid (HDEHP) impregnated on XAD-7 resin. In the present paper, the extraction behavior of Sr(II) and Y(III) was studied as a function of the concentration of nitric acid in the aqueous phase and concentration of HDEHP in the resin phase. The separation of Sr(II) and Y(III) was standardized using the above resins and the method was subsequently applied satisfactorily for the removal of yttrium from the dissolver solution of FBTR irradiated yttria pellet towards the purification of 89Sr. A baseline separation of 89Sr and Y was achieved. Leaching and breakthrough capacity studies were evaluated for the resins and it was established that the stability and capacity of the resins were satisfactory. The breakthrough capacity was found to be 12 mg Y(III) per gram of the HDHEP resin whereas the leaching studies established that the resins are stable for multiple cycle of operations.
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Egenvall, A., A. Byström, L. Roepstorff, M. Rhodin, M. Eisersiö, and H. M. Clayton. "Modelling rein tension during riding sessions using the generalised additive modelling technique." Comparative Exercise Physiology 14, no. 4 (2018): 209–21. http://dx.doi.org/10.3920/cep180017.
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General additive modelling (GAM-modelling) is an exploratory technique that can be used on longitudinal (time series) data, e.g. rein tension, over a period of time. The aim was to apply GAM-modelling to investigate changes in rein tension during a normal flatwork training session. Six riders each rode two or three of their horses (n=17 horses) during a normal flatwork/dressage training session with video recordings and rein tension measurements (128 Hz). Training sessions were classified according to rider position, stride length and whether horses were straight, bent to the left or bent to the right. The rein tension data were split into strides and for each stride minimal (MIN) and maximal (MAX) rein tension were determined and the area under the rein tension curve (AUC) was calculated. Using data on a contact the three outcome variables MIN, MAX and AUC rein tension were modelled by horse and rein (left/right), and time within the session was modelled as a smooth function. Two additional sets of models were constructed; one set using data within-rein with gait as a fixed effect and one set with rein and gait as fixed effects. Mean ± standard deviation values were MIN: 8.0±7.7 N, AUC: 180±109 Ns, and MAX: 49±31 N. GAM-modelling extracted visually interpretable information from the originally chaotic rein tension signals. Modelled data suggest that MIN, AUC and MAX follow the same pattern within horse. In general, rein tension was lowest in walk, intermediate in trot and highest in canter. Evaluating the entire ride, 12/17 horses systematically showed higher tension in the right rein. It is concluded that GAM-models may be useful for detecting patterns through time in biomechanical data.
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Silva, Ronaldo Corrêa Ferreira da. "Breast Cancer Screening: an Examination of Scientific Evidence." Revista Brasileira de Cancerologia 63, no. 4 (2019): 285–86. http://dx.doi.org/10.32635/2176-9745.rbc.2017v63n4.139.
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O livro é um compilado de textos de mais de 30 pesquisadores, especialistas no rastreamento do câncer de mama, representando países com larga experiência no rastreamento mamográfico como os EUA , Canadá, Reino Unido, Suécia, Holanda e Austrália. Com maior presença de pesquisadores da Austrália e EUA , onde predominam respectivamente o rastreamento organizado e oportunístico, o livro permite ao leitor um conhecimento abrangente sobre um tema relativamente complexo e ainda pouco explorado em países em desenvolvimento.
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Krome, Dr Susanne. "Metastasiertes Nierenzellkarzinom." Onkologische Welt 09, no. 05 (2018): 227. http://dx.doi.org/10.1055/s-0038-1677593.
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Vor Einführung der zielgerichteten Behandlungen verlängerte die zytoreduktive Nephrektomie vor einer Immuntherapie das Überleben. Studien ergaben einen Überlebensvorteil, wenn Nephrektomien bei einer Sunitinibtherapie verzögert stattfanden. Die prospektive Phase-III-Studie CARMENA (Cancer du Rein Metastatique Nephrectomie et Antiangiogeniques) zeigte nun, dass ein Verzicht auf die Operation möglich ist.
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Mqirage, Mohammed, José Antonio Zabala Egurrola, Jorge García-Olaverri Rodríguez, and Carlos Pertusa Peña. "Métastase pancréatique métachrone du cancer du rein : A propos d’un cas." Canadian Urological Association Journal 7, no. 5-6 (2013): 460. http://dx.doi.org/10.5489/cuaj.1388.
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Les métastases pancréatiques du cancer du rein sont rares et surviennent le plus souvent plusieurs années après la néphrectomie. Le traitement chirurgical est souvent possible, permettant une bonne survie à distance. Nous rapportons le cas d’une métastase pancréatique métachrone d’un carcinome rénal à cellules claires 16 ans après la néphrectomie.
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Tsivov, Aleksey Vladimirovich, Viktor Andreevich Kuvshinov, Denis Alekseevich Mazalyov, Mariya Nikolaevna Zavorueva, Vera Vyacheslavovna Eliseeva, and Aleksandr Alekseevich Smirnov. "The use of multimodal resins for purification of therapeutic monoclonal antibodies." Terapevt (General Physician), no. 1 (January 1, 2021): 10–16. http://dx.doi.org/10.33920/med-12-2101-02.
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Obtaining protein samples with high yield, high purity, and high activity is the foundation for most modern biological studies. Besides, highly purified protein preparations, such as monoclonal antibodies, have been widely used in the treatment of cancer, genetic and orphan diseases.
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Fernandes, Bruno Jose Dumêt, and Ricardo David Couto. "Toxicological alert: Exposure to glycidyl methacrylate and cancer risk." Toxicology and Industrial Health 36, no. 12 (2020): 937–39. http://dx.doi.org/10.1177/0748233720957816.
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Glycidyl methacrylate (GMA; CAS no. 106-91-2) is a chemical monomer used in the manufacture of dental resins, can coatings and polymers. GMA has demonstrated toxicity to the ocular, digestive, respiratory and dermal systems. Human exposure occurs mainly in the workplace, but it can also happen through food. Although there were no available data on carcinogenicity of GMA, carcinogenic potential in the nasal cavity is highly expected. Further studies are needed to assess GMA exposure in humans. This study provides an alert of GMA human exposure and its genotoxic and carcinogenic potential.
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Mao, Yang, Louise Fortier, and Donald Wigle. "Évolution des taux de mortalité par cause au Québec." Articles 16, no. 1 (2008): 99–118. http://dx.doi.org/10.7202/600609ar.
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RÉSUMÉ L’évolution de la mortalité par cause, au Québec, pour les trois dernières décennies, est étudiée. Les espérances de vie et les années potentielles de vie perdues, de la naissance à 75 ans, sont calculées. De plus, les taux de mortalité des différentes provinces, pour certaines causes de décès, sont comparés. Il en résulte que le Québec connaît des taux de mortalité relativement élevés. Les causes de décès les plus inquiétantes sont le suicide et le cancer du poumon. Les maladies cérébro-vasculaires, le cancer de l’estomac et les maladies du rein connaissent, de leur coté, de nettes améliorations.
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Khan, Nadeem Ghani, Jacinta Correia, Divya Adiga, et al. "A comprehensive review on the carcinogenic potential of bisphenol A: clues and evidence." Environmental Science and Pollution Research 28, no. 16 (2021): 19643–63. http://dx.doi.org/10.1007/s11356-021-13071-w.
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AbstractBisphenol A [BPA; (CH3)2C(C6H4OH)2] is a synthetic chemical used as a precursor material for the manufacturing of plastics and resins. It gained attention due to its high chances of human exposure and predisposing individuals at extremely low doses to diseases, including cancer. It enters the human body via oral, inhaled, and dermal routes as leach-out products. BPA may be anticipated as a probable human carcinogen. Studies using in vitro cell lines, rodent models, and epidemiological analysis have convincingly shown the increasing susceptibility to cancer at doses below the oral reference dose set by the Environmental Protection Agency for BPA. Furthermore, BPA exerts its toxicological effects at the genetic and epigenetic levels, influencing various cell signaling pathways. The present review summarizes the available data on BPA and its potential impact on cancer and its clinical outcome.
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Riedinger, J., J. Basuyau, N. Eche, F. Bonnetain, M. F. Pichon, and P. Fargeot. "Prognostic value of change in CA 125 levels after the first cycle of induction chemotherapy for epithelial ovarian cancers: Results of a multicentric French study." Journal of Clinical Oncology 25, no. 18_suppl (2007): 16017. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.16017.
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16017 Background: CA 125 assays enable treatment-response monitoring in ovarian cancer. Patients and Methods: This multicentric study was performed to assess the predictive value with regard to pathologic complete response at surgical second look and the prognostic value of the serum CA 125 change (=rease [D], 50%, 25%, < 25%ase) after one or two courses of induction chemotherapy (CT) with platinum salts and cyclophosphamide Of the 494 stage IIc - IV patients who were treated at the French Cancer Centres of Dijon, Bordeaux, Toulouse, Rouen, Reims, Nantes, Angers, Saint Cloud, 397 (80.4%d and 382 (77.3%om cancer. Median (range) follow up time was 34 months (3 - 215 months). Among them, 194 patients had a surgical second look. Results: The CA 125 change after the first, the second and the two first CT courses and CA 125 concentration (> or =-1) before the third CT cycle had an univariate prognostic value for overall survival (OS) (p < 0.0001 for both). In Cox models, CA 125 change after the first CT course (p < 0.0001), residual tumour (p = CA 125 concentration before the second CT course (p =and patients’ age (p =were independent prognostic factors for OS. A normal CA 125 before each of the two first CT courses or a CA 125 decrease higher than 50%e first CT course with a CA 125 =-1 before the second CT course identify patients with good prognosis. Both criteria retained a significant value in predicting second-look findings by univariate and multivariate analysis (p < 0.0001). Conclusion: Among well-established prognostic factors in ovarian cancers, the CA 125 change after the first CT course was independent prognostic factors for both achievement of pathological complete response and OS. No significant financial relationships to disclose.
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Goiana-da-Silva, Francisco. "Errata a “Fiscalidade ao Serviço da Saúde Pública: A Experiência na Tributação das Bebidas Açucaradas em Portugal”." Acta Médica Portuguesa 31, no. 4 (2018): 233. http://dx.doi.org/10.20344/amp.10554.
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Na página 191, onde se lê na linha de autoria:Francisco GOIANA-DA-SILVA1,2, Alexandre Morais NUNES3,4, Marisa MIRALDO5, Alexandra BENTO6, João BREDA7, Fernando Ferreira ARAÚJO8,9Deverá ler-seFrancisco GOIANA-DA-SILVA1,2, Alexandre Morais NUNES3,4, Marisa MIRALDO5, Alexandra BENTO6, João BREDA7,8, Fernando Ferreira ARAÚJO9,10Na mesma página, em rodapé, onde nas afiliações dos autores se lê:1. Estudante Doutorando em Politicas de Saúde. Department of Surgery and Cancer. Imperial College Medical School. Londres. Reino Unido.2. Assistente Convidado de Gestão e Liderança em Saúde. Faculdade de Ciências da Saúde. Universidade da Beira Interior. Covilhã. Portugal.3. Professor Auxiliar Convidado. Unidade Curricular de Políticas de Saúde. Instituto Superior de Ciências Sociais e Políticas. Universidade de Lisboa. Lisboa. Portugal.4. Investigador. Centro de Administração e Políticas Públicas. Instituto Superior de Ciências Sociais e Políticas. Universidade de Lisboa. Lisboa. Portugal.5. Associate Professor. Health Economics Department. Imperial College London Business School. Healthcare Management Group. Londres. Reino Unido.6. Bastonária. Ordem dos Nutricionistas. Lisboa. Portugal.7. Programme Manager. Nutrition, Physical Activity and Obesity. World Health Organisation. Lisboa. Portugal.8. Secretário de Estado Adjunto e da Saúde. XXI Governo Constitucional. Lisboa. Portugal.9. Professor Auxiliar Convidado. Faculdade de Medicina. Universidade do Porto. Porto. Portugal.Deverá ler-se:1. Estudante Doutorando em Politicas de Saúde. Department of Surgery and Cancer. Imperial College Medical School. Londres. Reino Unido.2. Assistente Convidado de Gestão e Liderança em Saúde. Faculdade de Ciências da Saúde. Universidade da Beira Interior. Covilhã. Portugal.3. Professor Auxiliar Convidado. Unidade Curricular de Políticas de Saúde. Instituto Superior de Ciências Sociais e Políticas. Universidade de Lisboa. Lisboa. Portugal.4. Investigador. Centro de Administração e Políticas Públicas. Instituto Superior de Ciências Sociais e Políticas. Universidade de Lisboa. Lisboa. Portugal.5. Associate Professor. Health Economics Department. Imperial College London Business School. Healthcare Management Group. Londres. Reino Unido.6. Bastonária. Ordem dos Nutricionistas. Lisboa. Portugal.7. Programme Manager. Nutrition, Physical Activity and Obesity. World Health Organisation. Lisboa. Portugal.8. Head of the WHO European Office for Prevention and Control of Noncommunicable Diseases. Moscow. Russian Federation.9. Secretário de Estado Adjunto e da Saúde. XXI Governo Constitucional. Lisboa. Portugal.10. Professor Auxiliar Convidado. Faculdade de Medicina. Universidade do Porto. Porto. Portugal.Na página 194, entre o corpo do manuscrito e a listagem final de referências, deverá ler-se o seguinte parágrafo:OBSERVAÇÕESJoão Breda é funcionário da OMS. As suas declarações no âmbito deste artigo são da sua exclusiva responsabilidade.Artigo publicado com erros: https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/10222
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Manfredi, J., HM Clayton, and FJ Derksen. "Effects of different bits and bridles on frequency of induced swallowing in cantering horses." Equine and Comparative Exercise Physiology 2, no. 4 (2005): 241–44. http://dx.doi.org/10.1079/ecp200569.
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AbstractIt has been suggested that the presence of a bit reflexly increases salivation but, at the same time, interferes with the horse's ability to swallow. The objective of this study was to compare swallowing frequency in 12 horses exercising at canter while wearing a head collar, a bitless bridle, a jointed snaffle bit and a Myler correctional-ported barrel bit. Laryngeal movements were recorded videoendoscopically as the horses cantered (8 m s−1) on a high speed treadmill, with the use of side reins to flex the poll. Swallowing was stimulated artificially by infusion of sterile water at a constant rate of 5 ml min−1 through a cannula in the endoscope's biopsy port. The results showed large differences in swallowing frequency between horses. Swallowing frequency was lower for the Myler snaffle than for the other conditions (P<0.05). It is concluded that the presence of a bit does not preclude swallowing during exercise at canter with the poll in a flexed position, but certain types of bits may be associated with a reduction in swallowing frequency.
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Kukurtchyan, N. S., and G. R. Karapetyan. "LIGHT OPTICAL STUDY OF HUMAN BREAST CANCER TISSUE EMBEDDED IN EPOXY REZINS." European Chemical Bulletin 6, no. 6 (2017): 229. http://dx.doi.org/10.17628/ecb.2017.6.229-231.
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Ignacio, Rosa Mistica C., Syeda M. Kabir, Eun-Sook Lee, Samuel E. Adunyah та Deok-Soo Son. "NF-κB-Mediated CCL20 Reigns Dominantly in CXCR2-Driven Ovarian Cancer Progression". PLOS ONE 11, № 10 (2016): e0164189. http://dx.doi.org/10.1371/journal.pone.0164189.
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Tzafetas, Menelaos, Anita Mitra, Maria Paraskevaidi, et al. "The intelligent knife (iKnife) and its intraoperative diagnostic advantage for the treatment of cervical disease." Proceedings of the National Academy of Sciences 117, no. 13 (2020): 7338–46. http://dx.doi.org/10.1073/pnas.1916960117.
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Clearance of surgical margins in cervical cancer prevents the need for adjuvant chemoradiation and allows fertility preservation. In this study, we determined the capacity of the rapid evaporative ionization mass spectrometry (REIMS), also known as intelligent knife (iKnife), to discriminate between healthy, preinvasive, and invasive cervical tissue. Cervical tissue samples were collected from women with healthy, human papilloma virus (HPV) ± cervical intraepithelial neoplasia (CIN), or cervical cancer. A handheld diathermy device generated surgical aerosol, which was transferred into a mass spectrometer for subsequent chemical analysis. Combination of principal component and linear discriminant analysis and least absolute shrinkage and selection operator was employed to study the spectral differences between groups. Significance of discriminatory m/z features was tested using univariate statistics and tandem MS performed to elucidate the structure of the significant peaks allowing separation of the two classes. We analyzed 87 samples (normal = 16, HPV ± CIN = 50, cancer = 21 patients). The iKnife discriminated with 100% accuracy normal (100%) vs. HPV ± CIN (100%) vs. cancer (100%) when compared to histology as the gold standard. When comparing normal vs. cancer samples, the accuracy was 100% with a sensitivity of 100% (95% CI 83.9 to 100) and specificity 100% (79.4 to 100). Univariate analysis revealed significant MS peaks in the cancer-to-normal separation belonging to various classes of complex lipids. The iKnife discriminates healthy from premalignant and invasive cervical lesions with high accuracy and can improve oncological outcomes and fertility preservation of women treated surgically for cervical cancer. Larger in vivo research cohorts are required to validate these findings.
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Rockwood, D. L., G. M. Blakeslee, G. A. Lowerts, E. M. Underhill, and S. W. Oak. "Genetic Strategies for Reducing Pitch Canker Incidence in Slash Pine." Southern Journal of Applied Forestry 12, no. 1 (1988): 28–32. http://dx.doi.org/10.1093/sjaf/12.1.28.
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Abstract Seedlings or ramets from 224 slash pine (Pinus elliottii var. elliottii Engelm.) clones were evaluated for resistance to the pitch canker fungus Fusarium moniliforme var. subglutinans Wollenw. & Reink. (FMS). Heritabilities and associated genetic gains calculated in five field tests suggest that pitch canker incidence can be reduced through appropriate genetic strategies. Three short-term strategies may be used to reduce incidence: use of an east-central Florida seed source, use of seed from resistant clones in existing orchards, and use of seed from seed production areas developed in epidemic areas. Longer term strategies involving new clonal orchards are predicted to decrease incidence significantly. Pitch canker resistance does not appear to be genetically related to good growth or to resistance to fusiform rust (Cronartium quercuum [Berk] Miyabe ex Shirai f. sp. fusiforme). South. J. Appl. For. 12(1):28-32.
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Xue, RuoBing, Satish Maharaj, Rohit Kumar, and Goetz H. Kloecker. "Does multiplicity of synchronous multiple lung primaries (SMLPs) affect prognosis." Journal of Clinical Oncology 39, no. 15_suppl (2021): e20530-e20530. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.e20530.
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e20530 Background: SMLPs are detected more commonly due to advancements in screening technology. Their workup and classification; however, are still lacking a clear standard. T stage of the largest lesion has been used as the major prognostic marker. This; however, does not take the number of SMLPs and their genomic drivers into consideration. This study aims to identify and review common risk factors associated with SMLPs and determine whether the number of primaries influence the prognosis. Methods: A systematic review of the literature published between 2000 and 2021 was conducted through PubMed and Medline by using the combination of keywords, including: “synchronous multiple primary lung cancer”, “simultaneous multifocal lung cancer”, “synchronous solitary lung metastasis”, “risk factor” and “prognosis”. A total of fifty studies were identified, among them only sixteen retrospective research articles and two review articles were relevant to the study at hand. Results: Sixteen retrospective studies including a total of 1685 eligible patients were reviewed. Thirteen of these studies reported the main histology type to be adenocarcinoma with a ratio ranging from 35% to 96.8%. Eight studies have reported the numbers of synchronous primary lung cancers, including one study found 11 SMLPs. Among these, one study by van Rens found number of SMLPs impact prognosis adversely compared to a single lung cancer. However, three other studies demonstrated multiple SMPLs do not adversely affect survival (Finley et al, 2010; Kocaturk et al, 2011; Li et al, 2020). Four of the sixteen studies analysed the effect of multiple lobes involvement and distance between tumors, with varying conclusions; two studies reported no difference in prognosis while one study revealed worse survival with multiple lobe involvement and one study found favorable outcome. Most studies confirm the usual prognostic factors for SMLPs, including: gender, smoking, type of surgery, comorbidities and adjuvant therapy. The median 5 year OS reported for SMLPs is 66%, with a wide range from 19% to 95.8%.The 3 year OS is 75% in most studies. Conclusions: The data on how the number of SMLPs affects the prognosis is uncertain. The current recommendation to base the decision for adjuvant therapy on the highest T stage is not supported by prospective evidence or consistent among published case series. Considering the recent approval of targeted therapies in early stage lung cancers, a better prognostic scoring system for SMLPs is required.
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Bertazzi, Pier A., A. C. Pesatori, L. Radice, Carlo Zocchetti, and T. Vai. "Exposure to formaldehyde and cancer mortality in a cohort of workers producing resins." Scandinavian Journal of Work, Environment & Health 12, no. 5 (1986): 461–68. http://dx.doi.org/10.5271/sjweh.2111.
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Padilla de la Rosa, J., Priscilla Ruiz-Palomino, Enrique Arriola-Guevara, Jorge García-Fajardo, Georgina Sandoval, and Guadalupe Guatemala-Morales. "A Green Process for the Extraction and Purification of Hesperidin from Mexican Lime Peel (Citrus aurantifolia Swingle) that is Extendible to the Citrus Genus." Processes 6, no. 12 (2018): 266. http://dx.doi.org/10.3390/pr6120266.
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The processing of Mexican limes generates great amounts of peel as a by-product. Lime peel is mainly rich in the flavonoid hesperidin, whose bioactivity is oriented mainly to cardiovascular diseases and cancer. The purpose of this work was to develop a green process for the extraction and purification of hesperidin from Mexican lime peel. The extraction of hesperidin was investigated on a laboratory scale by varying the solvent composition and the solid-to-solvent ratio, and then scaling this process (volume: 20 L). Next, a purification process using adsorption resins was assessed: first through static tests to determine the adsorption efficiency with two resins (FPX66, EXA118), and then on a packed column with 80 mL of resin at 25 °C. Lab-scale extraction showed that the best conditions were a solid-to-solvent ratio of 0.33 g/mL and 60% ethanol. After using these conditions at pilot scale and concentrating the solution, the hesperidin content of the extract was 0.303 mg/mL. Through static tests, higher adsorption efficiencies were achieved with the EXA-118 resin and diluted extract (4:6 ratio with 10% dimethylsulfoxide, (DMSO)). Finally, the purification process on a packed column from the diluted extract (hesperidin concentration of 0.109 mg/mL) had a mean recovery efficiency of almost 90%.
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Savov, Viktor, and Petar Antov. "Engineering the Properties of Eco-Friendly Medium Density Fibreboards Bonded with Lignosulfonate Adhesive." Drvna industrija 71, no. 2 (2020): 157–62. http://dx.doi.org/10.5552/drvind.2020.1968.
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Free formaldehyde emissions from wood-based panels, especially in indoor applications, pose serious risks to human health at certain concentrations. Prolonged exposure to formaldehyde can cause adverse health effects including eye, nose and throat irritation, other respiratory symptoms and cancer. As a consequence, new formaldehyde emission limits for composite wood products were established in Europe, USA and Japan. This, together with the stricter environmental legislation are the main driving factors for shifting the scientific and industrial interest from the traditional formaldehyde-based synthetic resins to the new bio-based adhesives for production of eco-friendly wood-based panels. The lignin-based products are one of the most prospective ecological alternatives to the traditional formaldehyde resins. The main interest in lignin is due to its phenolic structure with several favourable properties for the formulation of wood adhesives such as high hydrophobicity and low polydispersity. The present article is aimed at studying the possibilities for using lignosulfonate as an adhesive for the production of eco-friendly MDF. Regression models describing the impact of lignosulfonate concentration and hot pressing temperature on the exploitation properties of MDF panels were developed. The individual and combined impact of both factors was analysed in order to determine the optimal exploitation properties of the panels.
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Cao, Qian, Shao-Xiang Wang, and Yong-Xian Cheng. "Abietane Diterpenoids With Potent Cytotoxic Activities From the Resins of Populus euphratica." Natural Product Communications 14, no. 5 (2019): 1934578X1985002. http://dx.doi.org/10.1177/1934578x19850029.
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A new abietane norditerpenoid, 5-(6-isopropyl-2-methylnaphthalen-1-yl)pentan-2-one (1), with a rare 4,5-seco-19-norabietane skeleton possessing a rearranged angular methyl group at C-5, 2 new naturally occurring compounds, 19-norabieta-4,6,8,11,13-penttaen-3-one (2) and 14-hydroxy-7-oxo ester (3), along with 10 known analogs (4−13) were isolated from the resins of Populus euphratica. The new structures were elucidated by spectroscopic analysis (one-/two-dimensional nuclear magnetic resonance and high-reolution electrospray ionization mass spectrometry). Biological evaluation showed that compounds 1 and 2 display low cytotoxicity against normal cells and appreciable cytotoxicity in cancer cells, with 2 to be more sensitive in HepG2 cells with a half-maximal inhibitory concentration value of 27.0 μM.
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Verma, Indu, Pratibha Pundhir, Tejinder Kaur, Veena Jain, and Dinesh Sood. "Evaluation of Reid’s Combined Colposcopic Index as a predictor of cervical intraepithelial lesion." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 7, no. 9 (2018): 3724. http://dx.doi.org/10.18203/2320-1770.ijrcog20183784.
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Background: Carcinoma cervix is the commonest cancer among women worldwide and in India it accounts for 80% of all genital cancers. Screening methods include cervical cytology, human papilloma virus testing and colposcopy. Objective of present study was to evaluate suspicious cervix colposcopically using Reids Colposcopic Index (RCI) and to correlate RCI with histopathological findings.Methods: This was a prospective cross sectional study done on 125 women with clinical diagnosis of suspicious cervix. Colposcopy was performed and grading of the disease was done according to RCI. Positive cases were subjected to cervical biopsy and endocervical curettage was performed in unsatisfactory colposcopy.Results: Colposcopy was done on 125 women with suspicious cervix. Out of 125, sixty two showed abnormal colposcopic findings which were graded according to RCI into Low grade disease predicting histological diagnosis of CIN1 in 47, Intermediate grade disease predicting histological diagnosis of CIN1/2 in 11 and High grade disease predicting histological diagnosis of CIN2/3 in 4 women. Colposcopy of one women suggested invasive carcinoma and was confirmed on histopathology to be microinvasive squamous cell carcinoma. Six women with unsatisfactory colposcopy showed benign histopathology. Sensitivity, specificity, predictive value and false negative rate of colposcopy for invasive disease was 50%, 100%, 100% and 1.60% respectively with 98.40% diagnostic accuracy. Colposcopic diagnosis of invasive disease and histopathology report showed 100% correlation.Conclusions: Correlation between RCI and histopathology was good. Predictive accuracy of colposcopy increased with increasing severity of disease.
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Popolo, Ada, Anna Lisa Piccinelli, Silvana Morello, et al. "Cytotoxic activity of nemorosone in human MCF-7 breast cancer cells." Canadian Journal of Physiology and Pharmacology 89, no. 1 (2011): 50–57. http://dx.doi.org/10.1139/y10-100.
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Estrogen receptor (ER) antagonists have been widely used for breast cancer treatment; however, patients have increasingly shown resistance and sensitivity to the high toxicity of these drugs, and identification of novel targeted therapies is therefore required. To determine whether nemorosone, a polycyclic polyisoprenylated benzophenone isolated from floral resins of Clusia rosea Jacq. and Cuban propolis samples, exerts anticancer effects on human breast cancer cells, estrogen receptor positive (ERα+) MCF-7 and estrogen receptor negative (ERα–) MDA-MB-231 and LNCaP cells were used. Cells were treated with nemorosone alone or in association with 17β-estradiol (E2) or an ER antagonist, ICI 182,780, a selective ER downregulator that completely abrogates estrogen-sensitive gene transcription. Nemorosone inhibited the cell viability of ERα+ but not of ERα– cells. In MCF-7, nemorosone induced inhibition of cell growth by blocking the cell cycle in the G0/G1 phase. Moreover, the expression of pERK1/2 and pAkt, considered to be hallmarks of the nongenomic estrogen signalling pathway, were reduced in MCF-7 cells treated with nemorosone. All these effects were enhanced by ICI 182,780. However, nemorosone was not able to interfere with E2-induced Ca2+ release. These findings suggest that nemorosone may have therapeutic application in the treatment of breast cancer because of its activity on ERα.
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Ramli, Faiqah, Mawardi Rahmani, Intan Safinar Ismail, et al. "A New Bioactive Secondary Metabolite from Artocarpus elasticus." Natural Product Communications 11, no. 8 (2016): 1934578X1601100. http://dx.doi.org/10.1177/1934578x1601100818.
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Detailed phytochemical investigation has been carried out on the bark of Artocarpus elasticus Reinw. ex Blume, which led to the isolation of artonin E (1), a new dihydrobenzoxanthone derivative named elastixanthone (2), cycloartobiloxanthone (3) and artobiloxanthone (4). Structures of these compounds were elucidated on the basis of various spectroscopic (UV, IR, 1D-NMR and 2D-NMR) and MS data. Compounds 1-3 displayed outstanding scavenging activity for 1,1-diphenylpicrylhydrazyl (DPPH) with IC50 values of 11.5, 21.6 and 40.0 μg/mL, respectively. In addition, compounds 1-3 displayed broad spectrum antimicrobial activities against thirteen different bacterial strains when tested using the disc diffusion assay. Cytotoxic screening revealed that artonin E (1) constantly exhibited strong cytotoxic activity against human estrogen receptor (ER+) positive breast cancer (MCF-7) and human estrogen receptor (ER-) negative (MDA-MB 231) cells in comparison with the other two, with IC50 values of 2.6 and 13.5 μg/mL, respectively, without being toxic towards the WRL68 (human normal liver) cell line (IC50 value more than 30 μg/mL). However, the compound was inactive against HepG2 (human liver carcinoma) cancer cells.
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Salni, Salni, Arlina Ismaryani, Arum Setiawan, and Triwani Triwani. "Effect of extract and Salung Leaf Fraction (Psychotria viridiflora Reinv. Ex. Blume) As Sitotoksit, Antiproliferation and Applose of Apoptosis on Cancer Cell of Serviks HeLa." JURNAL ILMU KEFARMASIAN INDONESIA 16, no. 2 (2018): 206. http://dx.doi.org/10.35814/jifi.v16i2.528.
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Cervical cancer ranks second of cancer that affects women in the world and the first order for women in developing countries. Plant Salung (Psychotria viridiflora Reinw. Ex. Blume) have been used for generations to treat various diseases. The purpose of the study to determine the effects of leaf extracts and fractions salung as the anti-proliferation and inducer of apoptosis in HeLa cervical cancer cells. Concentration of extracts and fractions of 640; 320; 160; 80; 40 µg/mL, while cisplatin using a concentration of 200; 100; 50; 25 µg/mL. The results showed IC50 extract value 380.7 µg/mL. n-hexane fraction amounted to 229.3 µg/mL. ethyl acetate fraction of 116.8 µg/mL, and amounted to 562.8 µg/mL fraksi methanol water, so that the ethyl acetate fraction had enough categories active cytotoxic activity seen from the IC50. To further test the researchers only tested the active fraction is the fraction of ethyl acetate. Results ethyl acetate fraction doubling time is 58, which means replicating or proliferating cells on hour to 58 while the cells replicate cisplatin on the hour to 64.5 and the control cell on the hour to 41. Results of flowcytometry showed ethyl acetate fraction induce apoptosis by 72.82% while cisplatin 87.96%. It can be concluded that the extracts and fractions of leaves salung have a cytotoxic effect, acts as an anti-proliferation and inducer of apoptosis in HeLa cervical cancer cell.
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Fontaine, Mark S., and John L. Foltz. "ADULT SURVIVORSHIP, FECUNDITY, AND FACTORS AFFECTING LABORATORY OVIPOSITION OF PISSODES NEMORENSIS (COLEOPTERA: CURCULIONIDAE)." Canadian Entomologist 117, no. 12 (1985): 1575–78. http://dx.doi.org/10.4039/ent1171575-12.
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The deodar weevil, Pissodes nemorensis Germar, is a vector and wounding agent associated with pitch canker fungus, Fusarium moniliforme Sheld. var. subglutinans Wr. & Reink., in the southeastern United States (Blakeslee et al. 1981). This univoltine weevil breeds in southern pines that have been stressed by factors such as fire, lightning, or mechanical injury (Baker 1972). The adults feed on phloem after chewing through the outer bark. Females deposit eggs in some of these feeding pits and then plug the hole with macerated phloem (Atkinson 1979). Larvae tunnel under the bark and feed on phloem as they develop.
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Budianto, Rachmat, Hikmah M. Ali, and Effendi Abustam. "Antioxidant Activities of Beef Sausage with Addttion of Kluwak (Pangium edule Reinw)." Hasanuddin Journal of Animal Science (HAJAS) 1, no. 1 (2019): 45–54. http://dx.doi.org/10.20956/hajas.v1i1.7140.
Full textAbstract:
Oxidation is one of the important factors that affect the quality of meat products including sausages. To inhibit oxidation, ingredients need to be added in the process of making sausages which act as antioxidants. One plant that functions as a natural antioxidant is kluwak. Kluwak can be used to extend the shelf life. Kluwak 0 days and 40 days fermentation. Aside from being a preservative, kluwak seeds also contain antioxidant compounds and flavonoid groups. Antioxidant compounds that function as anti-cancer in kluwak seeds include vitamin C, iron ions, and Beta carotene which are the work of fermented kluwak seeds for 40 days. This study aimed to determine the effect of different types and levels of kluwak and their interactions on the physical characteristics and antioxidant activity of beef sausages during storage. This study uses two types of kluwak (0 days and fermentation 40 days), different levels and length of storage. Results of this study can increase antioxidant activity and reduce oxidation of lipid.
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Kukurtchyan, N. S., and G. R. Karapetyan. "THE STUDY OF MICROVESELS OF TISSUE EMBEDDED IN EPOXY RESINS AT HUMAN BREAST CANCER." European Chemical Bulletin 8, no. 12 (2019): 383. http://dx.doi.org/10.17628/ecb.2019.8.383-386.
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