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Dissertations / Theses on the topic 'Relapsed Rate'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Placenza, Franca M. "The involvement of substance P in relapse to cocaine-seeking behaviour in rats." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/MQ58709.pdf.

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2

Qrunfleh, Abeer Mostafa. "Activation of Glutamate Transporter 1 Attenuates Relapse to Alcohol-Seeking Behavior in Rats." University of Toledo Health Science Campus / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=mco1333557399.

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3

Minor, Tammy Lynn. "Behavioral Modification and Relapse Rates in Opioid-Dependent Pregnant Women Managed with Subutex." ScholarWorks, 2016. https://scholarworks.waldenu.edu/dissertations/1348.

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Behavioral Modification and Relapse Rates in Opioid-Dependent Pregnant Women Managed with Subutex by Tammy Minor MSN, Walden University, 2009 BSN, Marshall University, 1986 Project Submitted in Partial Fulfillment of the Requirements for the Degree of Doctor of Nursing Practice Walden University March 2016 Opioid dependency affects not only the individual who is dependent on opioids but negatively impactsalso the family unit, the community, and society as a whole. Opioid use in the prenatal period can have devastating effects on both the mother and the fetus. The purpose of this paper is to pe

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4

Nall, Rusty W. "Resurgence of Cocaine-Seeking in Rats Following Long Access and Punishment." DigitalCommons@USU, 2019. https://digitalcommons.usu.edu/etd/7558.

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Strategies that provide access to alternative non-drug rewards are among the most effective at reducing substance use in individuals with substance use disorders, but relapse often occurs when alternative rewards are removed. Relapse induced by the loss of alternative rewards is called resurgence, and represents a challenge to otherwise effective strategies for reducing drug use. An animal model has been useful for studying resurgence, but the extant model has two limitations. First, humans usually refer to the negative consequences of drug use as the reason they stop taking drugs, but the ext

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5

Doherty, James M. "Attenuated Effects of Opiates in Adolescent vs. Adult Male Rats: Reinforcement, Relapse, and Withdrawal." Digital Archive @ GSU, 2011. http://digitalarchive.gsu.edu/neurosci_diss/3.

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Adolescence in humans is a vulnerable period for illicit drug use, and teenage onset of drug use is associated with long-term addiction. Adolescent sensitivity to drug reinforcement, relapse, and withdrawal has not been explored thoroughly in animal models, especially considering opiate drugs such as morphine and heroin. The present series of studies profiles adolescent sensitivity to opiates using adolescent and adult male rats to test for age differences in opiate self-administration, reinstatement, withdrawal signs, locomotor sensitization, and even brain activation during drug-seeking.

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6

Afzal, Nadeem Ahmad. "Enteral nutrition feeding strategies and their impact on relapse rate and quality of life in paediatric Crohn's disease." Thesis, Queen Mary, University of London, 2010. http://qmro.qmul.ac.uk/xmlui/handle/123456789/695.

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Aims: To study induction of remission and reduction in relapse rate of childhood Crohn’s disease with quality of life (QOL) assessment in subjects on long term continuous oral supplementation with ACD004. Methods: This study was performed in two phases. In Phase A, ACD004 was used to assess effectiveness based on proportion of full remission at 8 weeks. Children then reintroduced food over a 4 week phase reducing their ACD004 intake to 30% RDA, subsequently enrolling into randomised controlled part of the trial (Phase B), to assess reduction in relapse rate whilst receiving continuous oral ACD

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7

Persson, Andreas, and Anna Willoughby. "Factors surrounding relapse rates at a treatment center in Sweden. : A quantitative study with male adolescents." Thesis, Högskolan i Gävle, Avdelningen för socialt arbete och psykologi, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:hig:diva-18264.

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This study primarily investigated factors which impact abstaining from drugs for adolescent men after finishing treatment at a specific treatment center in Sweden. The method chosen for this essay was quantitative, using surveys sent to males that finished a treatment period of a minimum time of 4 months at this therapeutic community. Of the 83 questionnaires that were originally sent, 23 responded. Further, the empirical data was tested in the computer program SPSS using gamma and lambda tests obtaining results for the factors to determine whether they correlated with one another other. The e

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8

Li, Chen. "Attenuated Cocaine Seeking After Adolescent-Onset of Cocaine Self-Administration in Male Rats: Behavior, Environment, and Genes." Digital Archive @ GSU, 2011. http://digitalarchive.gsu.edu/biology_diss/100.

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Recreational drug use peaks in the developmental stage of adolescence in humans. In this dissertation, we used a rodent model of adolescence and behavioral assessments of intravenous (i.v.) cocaine self-administration and reinstatement of cocaine-seeking to explore age differences in these cocaine-related behaviors, and then tested for the influence of environmental enrichment and for correlations between behavior and expression of plasticity genes. Although taking similar amount of cocaine, male rats trained to self-administer cocaine during adolescence (adolescent-onset) showed attenuated cu

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9

McClure-Rumpf, Karla W. "The effects of self-relevant mastery imagery on the level of self-efficacy and rate of relapse in the alcoholic patient /." free to MU campus, to others for purchase, 1996. http://wwwlib.umi.com/cr/mo/fullcit?p9737859.

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10

McIntosh, Byrne Donna. "The relationship between perceived family criticism and quality of life and relapse rates in patients with schizophrenia /." Thesis, McGill University, 1994. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=68214.

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Research has indicated that the adjustment of psychiatric patients is adversely affected by family criticism. The present study elaborated on this theme by focusing on fifty schizophrenic patients who were formally interviewed, using a standard visual analog scale format, about their perception of family criticism. Two important conceptual distinctions were proposed. The first was the extent to which criticism was perceived as "constructive" or "destructive", and the second was the extent to which the criticism was perceived to be "person directed" or "behavior directed". Regression analyses w

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11

Smith, Brooke M. "Effects of Differential Rates of Alternative Reinforcement on Resurgence of Human Behavior: A Translational Model of Relapse in the Anxiety Disorders." DigitalCommons@USU, 2015. https://digitalcommons.usu.edu/etd/4511.

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Behavioral and cognitive-behavioral psychotherapies utilizing exposure are considered the gold standard in anxiety disorder treatments. Despite their success, relapse remains problematic, especially over long-term follow up periods. Basic researchers traditionally conceptualize the mechanism of exposure as Pavlovian extinction, but this may overlook the important role of operant processes in the treatment and relapse of anxiety. Resurgence, in which a previously extinguished behavior returns following the extinction of another behavior that has replaced it, is a promising model of operant rela

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12

Connolly, Mark P., Gertruud Haitsma, Adrián V. Hernández, and José E. Vidal. "Systematic review and meta-analysis of secondary prophylaxis for prevention of HIV-related toxoplasmic encephalitis relapse using trimethoprim-sulfamethoxazole." Taylor and Francis Ltd, 2017. http://hdl.handle.net/10757/622484.

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A recent systematic literature and meta-analysis reported relative efficacy of trimethoprim-sulfamethoxazole (TMP-SMX) for the treatment of toxoplasmic encephalitis (TE) in HIV-infected adults. Here, we estimated relapse rates during secondary prophylaxis with TMP-SMX, and further explored differences in relapse rates prior to introduction of highly active antiretroviral therapy (HAART) and the widespread adoption of HAART. A systematic search of PubMed, Embase, and Cochrane Central Register of Controlled Trials yielded 707 studies whereby 663 were excluded after abstract screening, and 38 wer

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13

Pyszczynski, Adam D. "Selected Neuropharmacology of Resurgence." DigitalCommons@USU, 2013. https://digitalcommons.usu.edu/etd/1750.

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Resurgence refers to the reappearance of an extinguished operant behavior when reinforcement for an alternative behavior is also discontinued. It is especially relevant to the reappearance of problem behavior because many behavioral interventions discontinue reinforcement for aberrant behavior while simultaneously reinforcing an appropriate response. Existing information about the neuropharmacology of resurgence is scarce, but suggests overlap between drug seeking observed in the resurgence model and drug seeking observed in the more widely studied reinstatement and renewal models. The aim of

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14

Miles, Olivia. "Intra-Bed Nucleus of the Stria Terminalis Pituitary Adenylate Cyclase-Activating Peptide Infusion Reinstates Cocaine Seeeking in Rats." ScholarWorks @ UVM, 2016. http://scholarworks.uvm.edu/graddis/466.

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The tendency of users to relapse severely hinders adequate treatment of addiction. Physical and psychological stressors often contribute to difficulties in maintaining behavior change, and may play a significant role in relapse. We have previously shown that the activation of pituitary adenylate cyclase activating peptide (PACAP) systems in the bed nucleus of the stria terminalis (BNST) mediates many consequences of chronic stressor exposure. Hence, chronic stress substantially increased BNST PACAP levels, intra-BNST PACAP infusions produced the behavioral and endocrine consequences of stresso

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15

Palombo, Paola. "Participação de pequenos grupos neurais seletivamente ativados do córtex pré-límbico na reinstalação da autoadministração de etanol induzida pelo contexto." Universidade Federal de São Carlos, 2017. https://repositorio.ufscar.br/handle/ufscar/9177.

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Submitted by Daniele Amaral (daniee_ni@hotmail.com) on 2017-10-09T19:23:49Z No. of bitstreams: 1 DissPP.pdf: 2336243 bytes, checksum: 6713ce2a544f0c9590312b61ae159504 (MD5)<br>Approved for entry into archive by Ronildo Prado (producaointelectual.bco@ufscar.br) on 2017-10-31T13:11:51Z (GMT) No. of bitstreams: 1 DissPP.pdf: 2336243 bytes, checksum: 6713ce2a544f0c9590312b61ae159504 (MD5)<br>Approved for entry into archive by Ronildo Prado (producaointelectual.bco@ufscar.br) on 2017-10-31T13:11:59Z (GMT) No. of bitstreams: 1 DissPP.pdf: 2336243 bytes, checksum: 6713ce2a544f0c9590312b61ae159504

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16

Penzlin, Ana Isabel, Kristian Barlinn, Ben Min-Woo Illigens, Kerstin Weidner, Martin Siepmann, and Timo Siepmann. "Effect of short-term heart rate variability biofeedback on long-term abstinence in alcohol dependent patients – a one-year follow-up." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2017. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-230932.

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Background: A randomized controlled study (RCT) recently showed that short-term heart rate variability (HRV) biofeedback in addition to standard rehabilitation care for alcohol dependence can reduce craving, anxiety and improve cardiovascular autonomic function. In this one-year follow-up study we aimed to explore whether completion of 2-week HRV-Biofeedback training is associated with long-term abstinence. Furthermore, we sought to identify potential predictors of post-treatment abstinence. Methods: We conducted a survey on abstinence in patients with alcohol dependence 1 year after comple

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17

Rodríguez, Sodupe Pau 1993. "Liquid biopsy for early tumor relapse detection : Development of hypersensitive genomic sequencing methodologies for the detection of ultra-rare genetic variants in the blood plasma of pediatric cancer patients." Doctoral thesis, TDX (Tesis Doctorals en Xarxa), 2022. http://hdl.handle.net/10803/673741.

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The profiling of circulating-tumor DNA (ctDNA) in blood plasma, often known as liquid biopsy, has recently been of great interest in cancer research. This minimally-invasive strategy relies on the fact that ctDNA represents, at least partially, the real-time state of the tumor genome and holds great potential for early cancer detection and patient care. However, the fraction of ctDNA in total cell-free DNA (cfDNA) is often very low and requires ultra-sensitive and specific methods for its detection. This thesis focuses on the development and implementation of ultra-sensitive Next Generati

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18

Farrell-Lecomte, Veronica. "Mécanismes de latence et de recrudescence de l'infection toxoplasmique : étude du modèle rat Fischer infecté par la souche RH de Toxoplasma gondii." Université Joseph Fourier (Grenoble), 1993. http://www.theses.fr/1994GRE10069.

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Notre objectif a ete de mettre en place un modele experimental tres proche de l'homme infeste par t. Gondii ce qui nous a ensuite permis de mieux aborder les differents mecanismes qui determinent l'evolution de l'infection latente, surtout au niveau de la toxoplasmose cerebrale et leur dysfonctionnement pendant l'immuno-depression. Nos premieres investigations ont montre que la resistance des rats fischer a la souche rh est basee sur l'attenuation de sa virulence avec la formation de kystes cerebraux. L'analyse genotypique (fingerprinting) et metabolique (isoenzyme) de ces kystes montrent que

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19

Steinvorth, Simon Moritz [Verfasser], Tim [Akademischer Betreuer] Friede, Mikael [Akademischer Betreuer] Simons, and Martin [Akademischer Betreuer] Oppermann. "Explaining temporal trends in annualized relapse rates in placebo groups of randomized controlled trials in relapsing multiple sclerosis : Systematic review, meta-analysis and meta-regression / Simon Moritz Steinvorth. Gutachter: Tim Friede ; Mikael Simons ; Martin Oppermann. Betreuer: Tim Friede." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2014. http://d-nb.info/104698716X/34.

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20

Novakovic, Ana M. "Longitudinal Models for Quantifying Disease and Therapeutic Response in Multiple Sclerosis." Doctoral thesis, Uppsala universitet, Institutionen för farmaceutisk biovetenskap, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-316562.

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Treatment of patients with multiple sclerosis (MS) and development of new therapies have been challenging due to the disease complexity and slow progression, and the limited sensitivity of available clinical outcomes. Modeling and simulation has become an increasingly important component in drug development and in post-marketing optimization of use of medication. This thesis focuses on development of pharmacometric models for characterization and quantification of the relationships between drug exposure, biomarkers and clinical endpoints in relapse-remitting MS (RRMS) following cladribine trea

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21

Ritter, Victor Silva. "Modelagem de dados de longa duração baseada em processos de nascimento e morte latentes." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/45/45133/tde-09102014-142025/.

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Esse trabalho contribui com o desenvolvimento de um novo modelo para dados de sobrevivência com sobreviventes de longo termo visando uma formulação e interpretação mais realista do que a apresentada pelos modelos com fração de curados usuais. Motivados pelo estudo do tempo de sobrevivência residual para pacientes oncológicos, o modelo usa o processo de nascimento e morte para permitir a variação do número de fatores de risco latentes durante um período precedente ao acompanhamento médico, considerando, então, um cenário de riscos competitivos para obtenção da função da sobrevivência (imprópria

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22

Jos?, Junior Vanderlei. "Associa??o da Radioterapia externa (RTe) com braquiterapia de alta taxa de dose (BTATD), no tratamento do c?ncer de pr?stata (CaP)." Pontif?cia Universidade Cat?lica de Campinas, 2017. http://tede.bibliotecadigital.puc-campinas.edu.br:8080/jspui/handle/tede/1007.

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Submitted by SBI Biblioteca Digital (sbi.bibliotecadigital@puc-campinas.edu.br) on 2018-02-15T12:50:05Z No. of bitstreams: 1 VANDERLEI JOSE JUNIOR.pdf: 1351825 bytes, checksum: 599d050ec951a6a8e7497a0cea5d2e17 (MD5)<br>Made available in DSpace on 2018-02-15T12:50:05Z (GMT). No. of bitstreams: 1 VANDERLEI JOSE JUNIOR.pdf: 1351825 bytes, checksum: 599d050ec951a6a8e7497a0cea5d2e17 (MD5) Previous issue date: 2017-12-15<br>Introduction: Prostate cancer is one of the most prevalent diseases in the male population, occupying the second position among malignant neoplasms. There are several thera

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23

Tsai, Meng-Huan, and 蔡孟桓. "Influence of low level laser on orthodontic tooth movement and relapse rate in rats." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/49365233152255541759.

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碩士<br>國立臺灣大學<br>臨床牙醫學研究所<br>101<br>Treatment duration is one of the major determinants for patients seeking orthodontic treatment. To avoid long treatment time, orthodontists have to design sound mechanics meeting the anchorage demands and delivering appropriate force system to the tooth and its supporting tissues. However, the more crucial factors related to the treatment efficiency may lie in the individual biological response which is still largely unknown, to the force system which orthodontists regularly delivered. Low level laser with specific power setting has been shown as a non-invasi

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24

Hansen, Kevin T. "The affect [sic] of psychotherapy and pharmacological treatment on sex offender relapse rates." 2004. http://link.library.utoronto.ca/eir/EIRdetail.cfm?Resources__ID=94845&T=F.

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25

Gamaleddin, Islam. "Role of the Cannabinoid System in Modulating the Reinforcing and Relapse Related Properties of Nicotine in Rats." Thesis, 2013. http://hdl.handle.net/1807/35825.

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There are several lines of evidence supporting the existence of a pivotal role of the cannabinoid system in mediating the reinforcing effects of nicotine. Characterization of the crosstalk between nicotine addiction and the cannabinoid system may have significant implications for our understanding of the neurobiological mechanisms underlying nicotine dependence. Objectives: The current series of experiments, we investigated the effects of activating CB1 receptors, modulating CB2 receptors as well as elevating levels of the endogenous cannabinoid ligand anandamide on nicotine taking and reinsta

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26

Steinvorth, Simon Moritz. "Explaining temporal trends in annualized relapse rates in placebo groups of randomized controlled trials in relapsing multiple sclerosis." Doctoral thesis, 2014. http://hdl.handle.net/11858/00-1735-0000-0022-5DFE-E.

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27

Brown, Zenya. "A Study of Corticotropin-releasing Factor-catecholamine Interactions in the Reinstatement of Cocaine Seeking in Rats." Thesis, 2012. http://hdl.handle.net/1807/33876.

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It has been well established that the stress-related neurochemical systems corticotropin-releasing factor (CRF), noradrenaline (NA), and dopamine (DA) mediate stress-induced reinstatement of drug seeking. The three series of experiments presented in this dissertation constitute a further exploration of the role these neurochemical circuits play in reinstatement by providing the first direct exploration of whether central CRF and catecholamine (NA and DA) systems interact to influence reinstatement of cocaine seeking. The primary objective of the first series of experiments was to determine w

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28

Bertholomey, Megan Lee. "ALTERATIONS IN THE SEEKING AND SELF-ADMINISTRATION OF ETHANOL AND ANXIETY-LIKE BEHAVIOR FOLLOWING EXPOSURE TO YOHIMBINE IN RATS SELECTIVELY BRED FOR HIGH ALCOHOL INTAKE." Thesis, 2011. http://hdl.handle.net/1805/2617.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>Stress has been shown to contribute to alcohol drinking; however, inconsistencies in both the clinical and pre-clinical literature speak to the need for better paradigms to study this interaction. The present experiments compared animal models of the propensity to consume ethanol, the selectively bred alcohol-preferring (P) and high-alcohol-drinking (HAD) rat lines, in their response to yohimbine on ethanol seeking and self-administration and anxiety-like behavior. The P and HAD lines consume similar amounts of ethanol, yet differ in

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29

James, Morgan. "The role of cocaine- and amphetamine- regulated transcript (CART) and orexin in drug- seeking and addiction-related behaviours." Thesis, 2014. http://hdl.handle.net/1959.13/1042341.

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Research Doctorate - Doctor of Philosophy (PhD)<br>Over the past decade, two hypothalamic neuropeptides, cocaine- and amphetamine- regulated transcript (CART) and orexin (hypocretin), have been shown to play important roles in regulating addiction-relevant behaviours, including ‘reinstatement’ of drug-seeking, a model of relapse-like behaviour. Interestingly, CART generally opposes the rewarding effects of psychostimulant drugs such as cocaine and negatively regulates reinstatement of drug-seeking. In contrast, orexin generally promotes reinstatement of cocaine seeking. Despite intense interes

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30

Spinella, Jean-François. "Paysage génomique de la leucémie aiguë lymphoblastique de l’enfant." Thèse, 2016. http://hdl.handle.net/1866/18534.

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La leucémie aiguë lymphoblastique (LAL) est une maladie complexe à l’étiologie multifactorielle. Elle représente la forme la plus commune de cancer pédiatrique et malgré une augmentation significative du taux de survie des patients, près de 15% d’entre eux ne répondent pas aux traitements classiques et plus de 2/3 subissent les effets du traitement à long terme. Réduire ces chiffres passe par une meilleure compréhension des causes sous-jacentes de la LAL. À travers l’analyse des données de séquençage de nouvelle génération (SNG) de la cohorte QcALL du CHU Sainte-Justine, je me suis intéressé

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