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Journal articles on the topic 'Related protein identification'

Author: Grafiati

Published: 4 June 2021

Last updated: 13 February 2022

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1

Coleman, Matthew A., Kristi A. Miller, Peter T. Beernink, Daniel M. Yoshikawa, and Joanna S. Albala. "Identification of chromatin-related protein interactions using protein microarrays." PROTEOMICS 3, no. 11 (2003): 2101–7. http://dx.doi.org/10.1002/pmic.200300593.

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2

Du, Haibo, Rui Ren, Panpan Chen, Zhigang Xu, and Yanfei Wang. "Identification of Binding Partners of Deafness-Related Protein PDZD7." Neural Plasticity 2018 (2018): 1–10. http://dx.doi.org/10.1155/2018/2062346.

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PDZD7 is an important deafness gene, whose mutations are associated with syndromic and nonsyndromic hearing loss. PDZD7 contains multiple PDZ domains that are essential for organizing various proteins into protein complex. Several PDZD7-binding proteins have been identified, including usherin, ADGRV1, whirlin, harmonin, SANS, and MYO7A, all belonging to USH proteins. Here, we report the identification of novel PDZD7-binding partners through yeast two-hybrid screening using the first two PDZ domains of PDZD7 as bait. Eleven proteins were identified, most of which have not been reported as PDZD7

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3

Saqi, Mansoor A. S., and Michael J. E. Sternberg. "Identification of sequence motifs from a set of porteins with related function." "Protein Engineering, Design and Selection" 7, no. 2 (1994): 165–71. http://dx.doi.org/10.1093/protein/7.2.165.

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4

Zhang, Ren-wen, Yong Qiao, Xiao-hua Hao, et al. "Identification of Human Hepatocyte Proliferation Related Gene C2orf69." Infection International 3, no. 1 (2014): 1–9. http://dx.doi.org/10.1515/ii-2017-0066.

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Abstract Objective To construct the prokaryotic expression vector pET-32a(+)-C2orf69 and induce the expression of recombinant proteins in vitro. Then the possible effects of recombinant protein on cell proliferation was observed and rabbit-anti-C2orf69 protein polyclonal antibodies was obtained. Methods Gene fragment of C2orf69 was amplified by PCR and then prokaryotic expression plasmid pET-32a(+)-C2orf69 was constructed. Recombinant protein C2orf69 expression was identified by SDS-PAGE and Western blot. The white-ear rabbits were immunized with purified recombinant protein C2orf69, and the p

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5

Conlan, L. A., T. J. Martin, and M. T. Gillespie. "Identification of protein interactors with parathyroid hormone-related protein (PTHrP)." Bone 27, no. 4 (2000): 14. http://dx.doi.org/10.1016/s8756-3282(00)80037-x.

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6

Matsuo, Yoshiyuki, Nobutake Akiyama, Hajime Nakamura, Junji Yodoi, Makoto Noda, and Shinae Kizaka-Kondoh. "Identification of a Novel Thioredoxin-related Transmembrane Protein." Journal of Biological Chemistry 276, no. 13 (2001): 10032–38. http://dx.doi.org/10.1074/jbc.m011037200.

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7

Tassin, A. M., C. Celati, M. Paintrand, and M. Bornens. "Identification of an Spc110p-related protein in vertebrates." Journal of Cell Science 110, no. 20 (1997): 2533–45. http://dx.doi.org/10.1242/jcs.110.20.2533.

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Although varying in size and complexity, centrosomes have conserved functions throughout the evolutionary range of eukaryotes, and thus may display conserved components. In this work, we took advantage of the recent advances in the isolation of the budding yeast spindle pole body, the development of specific immunological probes and the molecular characterisation of genes involved in spindle pole body duplication or assembly. Screening a monoclonal antibody library against Saccharomyces cerevisiae spindle pole body components, we found that two monoclonal antibodies, directed against two diffe

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8

Roby, K. F., S. Deb, G. Gibori, et al. "Decidual prolactin-related protein. Identification, molecular cloning, and characterization." Journal of Biological Chemistry 268, no. 5 (1993): 3136–42. http://dx.doi.org/10.1016/s0021-9258(18)53669-3.

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9

Khurana, T. S., E. P. Hoffman, and L. M. Kunkel. "Identification of a chromosome 6-encoded dystrophin-related protein." Journal of Biological Chemistry 265, no. 28 (1990): 16717–20. http://dx.doi.org/10.1016/s0021-9258(17)44816-2.

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10

Frankel, Stewart, Matthew B. Heintzelman, Spyridon Artavanis-Tsakonas, and Mark S. Mooseker. "Identification of a Divergent Actin-related Protein in Drosophila." Journal of Molecular Biology 235, no. 4 (1994): 1351–56. http://dx.doi.org/10.1006/jmbi.1994.1090.

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11

Kuribara, Sayaka, Mai Kato, Takako Kato-Minoura, and Osamu Numata. "Identification of a novel actin-related protein inTetrahymena cilia." Cell Motility and the Cytoskeleton 63, no. 7 (2006): 437–46. http://dx.doi.org/10.1002/cm.20136.

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12

Zhu, Yimin, Xingyuan Xiao, Lairong Dong, and Zhiming Liu. "Investigation and Identification of let-7a Related Functional Proteins in Gastric Carcinoma by Proteomics." Analytical Cellular Pathology 35, no. 4 (2012): 285–95. http://dx.doi.org/10.1155/2012/691218.

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MicroRNAs are small noncoding RNA molecules that control expression of target genes. Our previous studies show that let-7a decreased in gastric carcinoma and that up-regulation of let-7a by gene augmentation inhibited gastric carcinoma cell growth bothin vitroandin vivo, whereas it remains largely unclear as to how let-7a affects tumor growth. In this study, proteins associated with the function of let-7a were detected by high throughout screening. The cell line of SGC-7901 stablely overexpressing let-7a was successfully established by gene cloning. Two-dimensional gel electrophoresis (2-DEy w

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13

Robertson, DM, LM Foulds, Vos F. de, L. Leversha, and Kretser DM de. "Identification of inhibin and inhibin-related proteins in human follicular fluid." Reproduction, Fertility and Development 2, no. 4 (1990): 327. http://dx.doi.org/10.1071/rd9900327.

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Inhibin-related proteins were identified in human follicular fluid following fractionation by gel permeation chromatography under neutral and acidic conditions, reversed-phase high performance liquid chromatography (HPLC) and preparative polyacrylamide gel electrophoresis. A number of molecular mass forms of inhibin (30-36 and 59-66 kDa) based on their in vitro biological and immunological activities were identified, of which 59-66 kDa inhibin was the predominant form. Bioactive fractions devoid of inhibin immunoactivity were also identified with molecular masses of 46 and 55 kDa. Based on the

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14

Phillips, R. J., S. Gustafson, and S. Ghosh. "Identification of a novel NF-kappaB p50-related protein in B lymphocytes." Molecular and Cellular Biology 16, no. 12 (1996): 7089–97. http://dx.doi.org/10.1128/mcb.16.12.7089.

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In most cell types other than mature B lymphocytes and macrophages, the transcription factor NF-kappaB remains in an inactive form in the cytosol by being bound to the inhibitory proteins IkappaBalpha and IkappaBbeta. To investigate the regulation of constitutively active NF-kappaB in B lymphocytes, we have examined the composition of Rel protein complexes in different mouse B-cell lines. As reported previously, the constitutively active complex in mature B cells was predominantly p50:c-Rel. However, the kappaB binding complex in the plasmacytomas that were examined lacked c-Rel and instead co

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15

Liu, Wen Qian, Li Li Zhou, Mei Su, Xu Juan Chi, and Jian Zhong Tan. "Separation and Identification of Proteins Related to Fruits Ripening in Mulberry (Morus alba)." Advanced Materials Research 175-176 (January 2011): 25–29. http://dx.doi.org/10.4028/www.scientific.net/amr.175-176.25.

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To elucidate the physiological mechanism of mulberry fruit ripening in protein level, differential proteome expression of mulberry fruits was analyzed by using 2-DE and mass spectrometry in different ripening stages, green ripe stage(G), half ripe stage(R) and pan ripe stage(P). A mulberry cultivator, “Da10” was used as experimental material. The results showed that separation of proteins with 2-DE were significantly improved by using phenol/SDS buffer for protein extraction. 441, 222, 328 protein spots were detected respectively in ripening stage G, R and P. Among them, differential expressio

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16

Usman, Muhammad Syafiuddin, Wisnu Ananta Kusuma, Farit Mochamad Afendi, and Rudi Heryanto. "Identification of Significant Proteins Associated with Diabetes Mellitus Using Network Analysis of Protein-Protein Interactions." Computer Engineering and Applications Journal 8, no. 1 (2019): 41–52. http://dx.doi.org/10.18495/comengapp.v8i1.283.

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Computation approach to identify significance of proteins related with disease was proposed as one of the solutions from the problem of experimental method application which is generally high cost and time consuming. The case of study was conducted on Diabetes Melitus (DM) type 2 diseases. Identification of significant proteins was conducted by constructing protein-protein interactions network and then analyzing the network topology. Dataset was obtained from Online Mendelian Inheritance in Man (OMIM) and Search Tool for the Retrieval of Interacting Genes/Proteins (STRING) which provided prote

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17

Lim, Dajeong, Nam-Kuk Kim, Hye-Sun Park, et al. "Identification of Candidate Genes related to Bovine Marbling using Protein-Protein Interaction Networks." International Journal of Biological Sciences 7, no. 7 (2011): 992–1002. http://dx.doi.org/10.7150/ijbs.7.992.

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18

Miyoshi, Akifumi, Katsumi Kito, Takayoshi Aramoto, Yasuhito Abe, Nobuaki Kobayashi, and Norifumi Ueda. "Identification of CGI-121, a novel PRPK (p53-related protein kinase)-binding protein." Biochemical and Biophysical Research Communications 303, no. 2 (2003): 399–405. http://dx.doi.org/10.1016/s0006-291x(03)00333-4.

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19

Zhang, Jian, Jing Yang, Tao Huang, Yang Shu, and Lei Chen. "Identification of novel proliferative diabetic retinopathy related genes on protein–protein interaction network." Neurocomputing 217 (December 2016): 63–72. http://dx.doi.org/10.1016/j.neucom.2015.09.136.

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20

Suratanee, Apichat, and Kitiporn Plaimas. "Identification of inflammatory bowel disease-related proteins using a reverse k-nearest neighbor search." Journal of Bioinformatics and Computational Biology 12, no. 04 (2014): 1450017. http://dx.doi.org/10.1142/s0219720014500176.

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Inflammatory bowel disease (IBD) is a chronic disease whose incidence and prevalence increase every year; however, the pathogenesis of IBD is still unclear. Thus, identifying IBD-related proteins is important for understanding its complex disease mechanism. Here, we propose a new and simple network-based approach using a reverse k-nearest neighbor ( R k NN ) search to identify novel IBD-related proteins. Protein–protein interactions (PPI) and Genome-Wide Association Studies (GWAS) were used in this study. After constructing the PPI network, the R k NN search was applied to all of the proteins

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21

Lelong, Christophe, Michel Mathieu, and Pascal Favrel. "Identification of new bone morphogenetic protein-related members in invertebrates." Biochimie 83, no. 5 (2001): 423–26. http://dx.doi.org/10.1016/s0300-9084(01)01260-3.

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22

Daigle, Nathalie, Peter A. Rogers, and Pierre M. Charest. "Spinach carbonic anhydrase: Identification of two immunologically related protein species." Phytochemistry 36, no. 5 (1994): 1129–32. http://dx.doi.org/10.1016/s0031-9422(00)89625-9.

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23

Bernardo, Maria Victoria, Estefania Yelo, Lourdes Gimeno, Maria Juliana Majado, Maria Rocio Alvarez-Lopez, and Antonio Parrado. "Identification of Apoptosis-Related Genes Regulated by the PLZF Protein." Blood 108, no. 11 (2006): 4339. http://dx.doi.org/10.1182/blood.v108.11.4339.4339.

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Abstract The PLZF gene was identified in acute promyelocytic leukemia (APL, AML-M3). PLZF expression is altered in chronic lymphocytic leukemia (CLL). PLZF is a transcriptional repressor involved in the control of cell proliferation, differentiation and survival. Overexpression of PLZF induces cell cycle arrest and growth suppression, whereas alteration of its normal function due to the presence of the reciprocal fusion proteins, PLZF-RARA and RARA-PLZF, resulting from the t(11;17) traslocation, is associated to the development of APL. We have established stable inducible PLZF expressor clones

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24

Martin, Harry, and Michael Dean. "Identification of a thioredoxin — related protein associated with plasma membranes." Biochemical and Biophysical Research Communications 175, no. 1 (1991): 123–28. http://dx.doi.org/10.1016/s0006-291x(05)81209-4.

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25

Palmer, R. H., J. Ridden, and P. J. Parker. "Identification of multiple, novel, protein kinase C-related gene products." FEBS Letters 356, no. 1 (1994): 5–8. http://dx.doi.org/10.1016/0014-5793(94)01202-4.

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26

Leel, Val, Lucy J. Elrick, Jorges Solares, et al. "Identification of a truncated ratp28-related protein expressed in kidney." Biochemical and Biophysical Research Communications 316, no. 3 (2004): 872–77. http://dx.doi.org/10.1016/j.bbrc.2004.02.137.

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27

Chiou, Jia-Yia, Shwu-Ju Huang, Shiann-Tarng Huang, and Wen-Long Cho. "Identification of immune-related protein kinases from mosquitoes (Aedes aegypti)." Journal of Biomedical Science 5, no. 2 (1998): 120–26. http://dx.doi.org/10.1007/bf02258365.

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28

Shi, Mengxiao, Barbara Stauffer, Ramesh Bhat, et al. "Identification of iminooxothiazolidines as secreted frizzled related protein-1 inhibitors." Bioorganic & Medicinal Chemistry Letters 19, no. 22 (2009): 6337–39. http://dx.doi.org/10.1016/j.bmcl.2009.09.085.

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29

Fu, Qiantang, Shujia Li, and Diqiu Yu. "Identification of an Arabidopsis Nodulin-related protein in heat stress." Molecules and Cells 29, no. 1 (2009): 77–84. http://dx.doi.org/10.1007/s10059-010-0005-3.

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30

Zhang, Jian, Min Jiang, Fei Yuan, et al. "Identification of Age-Related Macular Degeneration Related Genes by Applying Shortest Path Algorithm in Protein-Protein Interaction Network." BioMed Research International 2013 (2013): 1–8. http://dx.doi.org/10.1155/2013/523415.

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This study attempted to find novel age-related macular degeneration (AMD) related genes based on 36 known AMD genes. The well-known shortest path algorithm, Dijkstra’s algorithm, was applied to find the shortest path connecting each pair of known AMD related genes in protein-protein interaction (PPI) network. The genes occurring in any shortest path were considered as candidate AMD related genes. As a result, 125 novel AMD genes were predicted. The further analysis based on betweenness and permutation test indicates that there are 10 genes involved in the formation or development of AMD and ma

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31

Helmer, S. D., P. J. Hansen, R. V. Anthony, W. W. Thatcher, F. W. Bazer, and R. M. Roberts. "Identification of bovine trophoblast protein-1, a secretory protein immunologically related to ovine trophoblast protein-1." Reproduction 79, no. 1 (1987): 83–91. http://dx.doi.org/10.1530/jrf.0.0790083.

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32

Xiong, Lizhong, Min-Woo Lee, Min Qi, and Yinong Yang. "Identification of Defense-Related Rice Genes by Suppression Subtractive Hybridization and Differential Screening." Molecular Plant-Microbe Interactions® 14, no. 5 (2001): 685–92. http://dx.doi.org/10.1094/mpmi.2001.14.5.685.

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Identification of host genes involved in defense responses is one of most critical steps leading to the elucidation of disease resistance mechanisms in plants. In this study, two different cloning strategies were employed to identify defense-related genes from a tropical japonica rice cultivar (Oryza sativa cv. Drew). With the use of bacterial colony arrays, differential screening of a blast fungus (Pyricularia grisea)-induced rice cDNA library led to the isolation of 22 distinct rice genes that are expressed differentially in response to blast infection. Sequence analysis indicates that most

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33

Li, Bi-Qing, Jian Zhang, Tao Huang, Lei Zhang, and Yu-Dong Cai. "Identification of retinoblastoma related genes with shortest path in a protein–protein interaction network." Biochimie 94, no. 9 (2012): 1910–17. http://dx.doi.org/10.1016/j.biochi.2012.05.005.

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34

Guignard, F., J. Mauel, and M. Markert. "Identification and characterization of a novel human neutrophil protein related to the S100 family." Biochemical Journal 309, no. 2 (1995): 395–401. http://dx.doi.org/10.1042/bj3090395.

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A rabbit polyclonal antibody raised against myeloid-related protein 8 (MRP-8), a protein of the S100 family, recognized another S100 protein (MRP-14) as well as a protein of 6.5 kDa (p6) in the cytosol of resting neutrophils. p6 was found to be a novel member of the S100 family. It consisted of two isoforms with pI values of 6.2 (the minor form, p6a) and 6.3 (the major form, p6b) and constituted 5% of the total cytosolic proteins. Both isoforms were also demonstrated in the cytosol of monocytes, but not in lymphocytes, as previously shown for MRP-8 and MRP-14. Only the major isoform bound radi

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35

Lee, B. A., D. W. Maher, M. Hannink, and D. J. Donoghue. "Identification of a signal for nuclear targeting in platelet-derived-growth-factor-related molecules." Molecular and Cellular Biology 7, no. 10 (1987): 3527–37. http://dx.doi.org/10.1128/mcb.7.10.3527.

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The v-vis gene encodes p28sis, the transforming protein of simian sarcoma virus. This gene resulted from a fusion of the env gene of simian sarcoma-associated virus and the woolly monkey gene for the B chain of platelet-derived growth factor (PDGF). Previous work has shown that the v-sis gene product undergoes signal sequence cleavage, glycosylation, dimerization, and proteolytic processing to yield a secreted form of the protein. It transport across the endoplasmic reticulum is blocked by the introduction of a charged amino acid residue within the signal sequence, the protein does not dimeriz

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36

Lee, B. A., D. W. Maher, M. Hannink, and D. J. Donoghue. "Identification of a signal for nuclear targeting in platelet-derived-growth-factor-related molecules." Molecular and Cellular Biology 7, no. 10 (1987): 3527–37. http://dx.doi.org/10.1128/mcb.7.10.3527-3537.1987.

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The v-vis gene encodes p28sis, the transforming protein of simian sarcoma virus. This gene resulted from a fusion of the env gene of simian sarcoma-associated virus and the woolly monkey gene for the B chain of platelet-derived growth factor (PDGF). Previous work has shown that the v-sis gene product undergoes signal sequence cleavage, glycosylation, dimerization, and proteolytic processing to yield a secreted form of the protein. It transport across the endoplasmic reticulum is blocked by the introduction of a charged amino acid residue within the signal sequence, the protein does not dimeriz

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37

Jung, Dongmin, and Xijin Ge. "PPInfer: a Bioconductor package for inferring functionally related proteins using protein interaction networks." F1000Research 6 (November 7, 2017): 1969. http://dx.doi.org/10.12688/f1000research.12947.1.

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Interactions between proteins occur in many, if not most, biological processes. This fact has motivated the development of a variety of experimental methods for the identification of protein-protein interaction (PPI) networks. Leveraging PPI data available STRING database, we use network-based statistical learning methods to infer the putative functions of proteins from the known functions of neighboring proteins on a PPI network. This package identifies such proteins often involved in the same or similar biological functions. The package is freely available at the Bioconductor web site (http:

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38

Jung, Dongmin, and Xijin Ge. "PPInfer: a Bioconductor package for inferring functionally related proteins using protein interaction networks." F1000Research 6 (December 8, 2017): 1969. http://dx.doi.org/10.12688/f1000research.12947.2.

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Interactions between proteins occur in many, if not most, biological processes. This fact has motivated the development of a variety of experimental methods for the identification of protein-protein interaction (PPI) networks. Leveraging PPI data available STRING database, we use network-based statistical learning methods to infer the putative functions of proteins from the known functions of neighboring proteins on a PPI network. This package identifies such proteins often involved in the same or similar biological functions. The package is freely available at the Bioconductor web site (http:

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39

Jung, Dongmin, and Xijin Ge. "PPInfer: a Bioconductor package for inferring functionally related proteins using protein interaction networks." F1000Research 6 (March 12, 2018): 1969. http://dx.doi.org/10.12688/f1000research.12947.3.

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Interactions between proteins occur in many, if not most, biological processes. This fact has motivated the development of a variety of experimental methods for the identification of protein-protein interaction (PPI) networks. Leveraging PPI data available in the STRING database, we use a network-based statistical learning methods to infer the putative functions of proteins from the known functions of neighboring proteins on a PPI network. This package identifies such proteins often involved in the same or similar biological functions. The package is freely available at the Bioconductor web si

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40

UMADEVI, S., K. PREMKUMAR, S. VALARMATHI, P. M. AYYASAMY, and S. RAJAKUMAR. "IDENTIFICATION OF NOVEL GENES RELATED TO DIABETIC RETINOPATHY USING PROTEIN–PROTEIN INTERACTION NETWORK AND GENE ONTOLOGIES." Journal of Biological Systems 24, no. 01 (2016): 117–27. http://dx.doi.org/10.1142/s0218339016500066.

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Diabetic retinopathy is the most common cause of blindness, associated with many biochemical pathways mediated by several genes and proteins. Disease gene identification can be achieved through several approaches but still it is a challenging task. This study, aimed to find out the novel genes associated with diabetic retinopathy. In this study, all the well-known genes associated with diabetic retinopathy were collected from databases and the protein interaction partners were identified. The interacting candidate genes were chosen by chromosomal locations, sharing with disease genes. The prot

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41

Shah, Pramod, and Chien-Sheng Chen. "Systematic Identification of Protein Targets of Sub5 Using Saccharomyces cerevisiae Proteome Microarrays." International Journal of Molecular Sciences 22, no. 2 (2021): 760. http://dx.doi.org/10.3390/ijms22020760.

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Antimicrobial peptides (AMPs) are intensively studied in terms of alternative drugs. Sub5 is a synthetic 12-mer AMP with substitutions of five amino acids of bactenecin 2A (Bac2A), a linear-ized bactenecin variant of bovine. Sub5 is highly effective against fungi with an ability to trans-locate cell membrane, but its targets are unknown. Systematic analysis of Sub5 targets will facil-itate our understanding on its mechanism of action. In this study, we used high-throughput Saccharomyces cerevisiae proteome microarrays to explore the potential protein targets of Sub5. The screening results show

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42

Kato-Minoura, T., S. Kuribara, M. Kato, and O. Numata. "2P223 Identification of a novel actin-related protein in Tetrahymena cilia." Seibutsu Butsuri 45, supplement (2005): S175. http://dx.doi.org/10.2142/biophys.45.s175_3.

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43

Lee, Y.-R. Julie, and Bo Liu. "Identification of a phragmoplast-associated kinesin-related protein in higher plants." Current Biology 10, no. 13 (2000): 797–800. http://dx.doi.org/10.1016/s0960-9822(00)00564-9.

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44

Kang, Ning, Lian Duan, Long Tang, et al. "Identification and Characterization of a Novel Thymus Aging Related Protein Rwdd1." Cellular & Molecular Immunology 5, no. 4 (2008): 279–85. http://dx.doi.org/10.1038/cmi.2008.34.

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45

LaMarco, K., C. Thompson, B. Byers, E. Walton, and S. McKnight. "Identification of Ets- and notch-related subunits in GA binding protein." Science 253, no. 5021 (1991): 789–92. http://dx.doi.org/10.1126/science.1876836.

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46

Conklin, Darrell, Debra Gilbertson, David W. Taft, et al. "Identification of a Mammalian Angiopoietin-Related Protein Expressed Specifically in Liver." Genomics 62, no. 3 (1999): 477–82. http://dx.doi.org/10.1006/geno.1999.6041.

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47

Cleghorn, Laura A. T., Andrew Woodland, Iain T. Collie, et al. "Identification of Inhibitors of the Leishmania cdc2-Related Protein Kinase CRK3." ChemMedChem 6, no. 12 (2011): 2214–24. http://dx.doi.org/10.1002/cmdc.201100344.

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48

Weissbach, L., J. Settleman, M. F. Kalady, et al. "Identification of a human rasGAP-related protein containing calmodulin-binding motifs." Journal of Biological Chemistry 269, no. 32 (1994): 20517–21. http://dx.doi.org/10.1016/s0021-9258(17)32023-9.

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49

AMERY, Leen, Hideki SANO, Guy P. MANNAERTS, et al. "Identification of PEX5p-related novel peroxisome-targeting signal 1 (PTS1)-binding proteins in mammals." Biochemical Journal 357, no. 3 (2001): 635–46. http://dx.doi.org/10.1042/bj3570635.

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Based on peroxin protein 5 (Pex5p) homology searches in the expressed sequence tag database and sequencing of large full-length cDNA inserts, three novel and related human cDNAs were identified. The brain-derived cDNAs coded for two related proteins that differ only slightly at their N-terminus, and exhibit 39.8% identity to human PEX5p. The shorter liver-derived cDNA coded for the C-terminal tetratricopeptide repeat-containing domain of the brain cDNA-encoded proteins. Since these three proteins specifically bind to various C-terminal peroxisome-targeting signals in a manner indistinguishable

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50

Lev, Sima, John Hernandez, Ricardo Martinez, Alon Chen, Greg Plowman, and Joseph Schlessinger. "Identification of a Novel Family of Targets of PYK2 Related to Drosophila Retinal Degeneration B (rdgB) Protein." Molecular and Cellular Biology 19, no. 3 (1999): 2278–88. http://dx.doi.org/10.1128/mcb.19.3.2278.

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ABSTRACT The protein tyrosine kinase PYK2 has been implicated in signaling pathways activated by G-protein-coupled receptors, intracellular calcium, and stress signals. Here we describe the molecular cloning and characterization of a novel family of PYK2-binding proteins designated Nirs (PYK2 N-terminal domain-interacting receptors). The three Nir proteins (Nir1, Nir2, and Nir3) bind to the amino-terminal domain of PYK2 via a conserved sequence motif located in the carboxy terminus. The primary structures of Nirs reveal six putative transmembrane domains, a region homologous to phosphatidylino

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