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Journal articles on the topic 'Relative hyperemia index'

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Published: 2 June 2025

Last updated: 31 July 2025

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1

Knaapen, Paul, Tjeerd Germans, Paolo G. Camici, et al. "Determinants of coronary microvascular dysfunction in symptomatic hypertrophic cardiomyopathy." American Journal of Physiology-Heart and Circulatory Physiology 294, no. 2 (2008): H986—H993. http://dx.doi.org/10.1152/ajpheart.00233.2007.

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Impaired hyperemic myocardial blood flow (MBF) in hypertrophic cardiomyopathy (HCM), despite normal epicardial coronary arteries, results in microvascular dysfunction. The aim of the present study was to determine the relative contribution of extravascular compressive forces to microvascular dysfunction in HCM. Eighteen patients with symptomatic HCM and normal coronary arteries and 10 age-matched healthy volunteers were studied with PET to quantify resting and hyperemic MBF at a subendocardial and subepicardial level. In HCM patients, MRI was performed to determine left ventricular (LV) mass i

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Chlasta-Twardzik, Edyta, Aleksandra Górecka-Nitoń, Anna Nowińska, and Edward Wylęgała. "The Influence of Work Environment Factors on the Ocular Surface in a One-Year Follow-Up Prospective Clinical Study." Diagnostics 11, no. 3 (2021): 392. http://dx.doi.org/10.3390/diagnostics11030392.

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The purpose of this study was to assess the effect of environmental working conditions on the symptoms and signs of dry eye disease and to examine whether and how those conditions impact the ocular surface. Methods: This single-center, prospective clinical study with a 1-year follow-up included 150 patients. The following parameters were evaluated: non-invasive keratograph break-up time (NIKBUT), tear meniscus height (TMH), and conjunctival and limbal hyperemia. We also performed staining of the surface of the eye for simulated fluorescein images, Schirmer’s test I, assessment of Meibomian gla

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Ejaz-ul-Haq, Muhammad. "Temporal Changes in Physical Signs of Estrus and Validation of Fetal Parameters for Estimation of Gestational Stage through B-mode Ultrasonography in Beetal goats." Pakistan Veterinary Journal 40, no. 04 (2020): 425–30. http://dx.doi.org/10.29261/pakvetj/2020.037.

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The current study evaluates changes in the physical signs of estrus (vulvar hyperemia, edema and mucous discharge) from their onset until ovulation, and validates fetal parameters for the estimation of gestational stage in Beetal goats. In experiment 1, temporal changes in estrus signs were monitored subjectively after the administration of two injections of PGF2α at 10-days interval and a cumulative behavioural index (BI) was calculated in goats that showed estrus response (n=7). Ovulation occurred after 18.8±2.3 h relative to peak vulvar hyperemia and edema; ovulation coincided with maximum

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Tyagi, Ravi, S. Samaduddin Ahmed, Yilun Koethe, Aleksandr Raskind, and Osman Ahmed. "Genicular Artery Embolization for Primary Knee Osteoarthritis." Seminars in Interventional Radiology 39, no. 02 (2022): 125–29. http://dx.doi.org/10.1055/s-0042-1745798.

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AbstractGenicular artery embolization (GAE) is a novel treatment for knee osteoarthritis (OA) with increasing interest and utilization worldwide. The genicular arteries are selectively embolized using microspheres with subsequent cessation of abnormal synovial hyperemia, a process believed to arrest the inflammatory changes and pain associated with OA. Current data indicate that GAE offers sustained, 6-month improvement in Western Ontario and McMaster Universities Osteoarthritis index (WOMAC) and visual analog scale scores in 80 to 85% of patients with mild to moderate OA. As GAE gains tractio

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Cooper, Leroy L., Na Wang, Alexa S. Beiser, et al. "Digital Peripheral Arterial Tonometry and Cardiovascular Disease Events: The Framingham Heart Study." Stroke 52, no. 9 (2021): 2866–73. http://dx.doi.org/10.1161/strokeaha.120.031102.

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Background and Purpose: Novel noninvasive measures of vascular function are emerging as subclinical markers for cardiovascular disease (CVD) and may be useful to predict CVD events. The purpose of our prospective study was to assess associations between digital peripheral arterial tonometry (PAT) measures and first-onset major CVD events in a sample of FHS (Framingham Heart Study) participants. Methods: Using a fingertip PAT device, we assessed pulse amplitude in Framingham Offspring and Third Generation participants (n=3865; mean age, 55±14 years; 52% women) at baseline and in 30-second inter

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Bugge, Merete Drevvatne, B. Ulvestad, B. Berlinger, L. Stockfelt, R. Olsen, and D. G. Ellingsen. "Reactive hyperemia and baseline pulse amplitude among smelter workers exposed to fine and ultrafine particles." International Archives of Occupational and Environmental Health 93, no. 3 (2019): 399–407. http://dx.doi.org/10.1007/s00420-019-01491-8.

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Abstract Objective Ambient exposure to fine particles is associated with increased cardiovascular morbidity and mortality. Associations between occupational particulate matter (PM) exposure and cardiovascular disease have been studied less. The objective of this study was to examine associations between PM exposure and endothelial function among workers in Norwegian smelters. Methods We examined endothelial function with Endo-PAT equipment after a working day (WD) and on a day off (DO) in 59 furnace workers recruited from three metal smelters in Norway. The difference in baseline pulse amplitu

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Manasyan, A. G., A. L. Dobkes, S. G. Manasyan, et al. "STUDY THE REGULATION OF PERIPHERAL BLOOD FLOW IN PATIENTSWITH CARDIOVASCULAR DISORDERS." HERALD of North-Western State Medical University named after I.I. Mechnikov 7, no. 2 (2015): 52–62. http://dx.doi.org/10.17816/mechnikov20157252-62.

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A new approach to evaluating of the state of cardiovascular system for patients with verified diagnosis of coronary heart disease (CHd), cardiac syndrome X (COAG) and hypertension (GB) by modification of known techniques of the PAT (peripheral arterial tonometry) is represented in the article. The results of studies by the method of us PAT patients with various cardiovascular disease indicate a particular clinical significance is not only the assessment of local «endothelial dysfunction» (the known value of reactive hyperemia index RHI), but also assess the nature of the Central system respons

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Hoffman, Robert P., Melanie M. Copenhaver, Danlei Zhou, and Chack-Yung Yu. "Oral glucose tolerance response curve predicts disposition index but not other cardiometabolic risk factors in healthy adolescents." Journal of Pediatric Endocrinology and Metabolism 34, no. 5 (2021): 599–605. http://dx.doi.org/10.1515/jpem-2020-0619.

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Abstract Objectives In obese adults the shape of the glucose response curve during an oral glucose tolerance test (OGTT) predicts future type 2 diabetes. Patients with an incessant increase or monophasic curves have increased risk compared to those with biphasic curves. Since type 2 diabetes is associated with increased cardiometabolic risk, we studied whether differences in OGTT response curve are associated with differences in cardiometabolic risk factors in healthy adolescents across a wide body mass index (BMI) range. Methods Sixty-nine (33F/36M), white adolescents (age: 15.2 ± 1.7 years;

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Yeo, Tsin W., Daniel A. Lampah, Retno Gitawati, et al. "Impaired nitric oxide bioavailability and l-arginine–reversible endothelial dysfunction in adults with falciparum malaria." Journal of Experimental Medicine 204, no. 11 (2007): 2693–704. http://dx.doi.org/10.1084/jem.20070819.

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Severe falciparum malaria (SM) is associated with tissue ischemia related to cytoadherence of parasitized erythrocytes to microvascular endothelium and reduced levels of NO and its precursor, l-arginine. Endothelial function has not been characterized in SM but can be improved by l-arginine in cardiovascular disease. In an observational study in Indonesia, we measured endothelial function using reactive hyperemia–peripheral arterial tonometry (RH-PAT) in 51 adults with SM, 48 patients with moderately severe falciparum malaria (MSM), and 48 controls. The mean RH-PAT index was lower in SM (1.41;

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GRANGE, ROBERT W., EIJI ISOTANI, KIM S. LAU, KRISTINE E. KAMM, PAUL L. HUANG, and JAMES T. STULL. "Nitric oxide contributes to vascular smooth muscle relaxation in contracting fast-twitch muscles." Physiological Genomics 5, no. 1 (2001): 35–44. http://dx.doi.org/10.1152/physiolgenomics.2001.5.1.35.

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During skeletal muscle contraction, NO derived from neuronal nitric oxide synthase (nNOS) in skeletal muscle fibers or from endothelial cells (eNOS) may relax vascular smooth muscle contributing to functional hyperemia. To examine the relative importance of these pathways, smooth muscle myosin regulatory light chain (smRLC) phosphorylation was assessed as an index of vascular tone in isolated extensor digitorum longus (EDL) muscles from C57, nNOS−/−, and eNOS−/− mice. The smRLC phosphorylation (in mol phosphate per mol smRLC) in C57 resting muscles (0.12 ± 0.04) was increased 3.7-fold (0.44 ±

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Sindrup, JH, Avnstorp C, HH Steenfos, and Kristensen JK. "Transcutaneous PO2 and laser Doppler blood flow measurements in 40 patients with venous leg ulcers." Acta Dermato-Venereologica 67, no. 2 (1987): 160–63. http://dx.doi.org/10.2340/0001555567160163.

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The study included 40 patients with clinically venous leg ulcer(s) in one leg only and with a systolic toe blood pressure above 50 mmHg in both legs. Transcutaneous oxygen tension was measured on both lower legs at equivalent sites, on the affected leg immediately proximal to the ulcer(s). Similarly, skin blood flow was measured in both legs at a skin temperature of 32 degrees C and 44 degrees C by means of laser Doppler velocimetry, and for each leg the index of blood flow 44 degrees C/flow 32 degrees C was calculated to express the degree of blood flow increment following local hyperthermia.

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Poitras, Veronica J., Robert F. Bentley, Diana H. Hopkins-Rosseel, Stephen A. LaHaye, and Michael E. Tschakovsky. "Independent effect of type 2 diabetes beyond characteristic comorbidities and medications on immediate but not continued knee extensor exercise hyperemia." Journal of Applied Physiology 119, no. 3 (2015): 202–12. http://dx.doi.org/10.1152/japplphysiol.00758.2014.

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We tested the hypothesis that type 2 diabetes (T2D), when present in the characteristic constellation of comorbidities (obesity, hypertension, dyslipidemia) and medications, slows the dynamic adjustment of exercising muscle perfusion and blunts the steady state relative to that of controls matched for age, body mass index, fitness, comorbidities, and non-T2D medications. Thirteen persons with T2D and 11 who served as controls performed rhythmic single-leg isometric quadriceps exercise (rest-to-6 kg and 6-to-12 kg transitions, 5 min at each intensity). Measurements included leg blood flow (LBF,

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Koshurba, I. V., F. V. Hladkykh, and M. O. Chyzh. "EVALUATION OF ANTIULCEROGENIC EFFECT OF CRYOCONSERVATED PLACENTA EXTRACT ON THE MODEL OF ETHANOL-PREDISONOLIC LESIONS OF THE GASTRIC MUCOSA." Medical Science of Ukraine (MSU) 18, no. 2 (2022): 3–9. http://dx.doi.org/10.32345/2664-4738.2.2022.01.

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Relevance. Gastric and duodenal ulcers occur in 6-10% of the adult population, and mortality from peptic ulcers ranges from 5 to 15%. Conservative treatment of this disease almost always involves the use of antisecretory and antibacterial drugs. Existing treatment regimens for peptic ulcer disease, focused on key pathogenetic mechanisms, do not take into account the individual adaptive and trophological characteristics of patients. As a potential antiulcer agent, our attention was drawn to the cryopreserved placenta extract ("Cryocell-cryoextract placenta"). It eliminates the ulcerogenic effec

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Ishii, Kei, Nan Liang, Anna Oue, et al. "Central command contributes to increased blood flow in the noncontracting muscle at the start of one-legged dynamic exercise in humans." Journal of Applied Physiology 112, no. 12 (2012): 1961–74. http://dx.doi.org/10.1152/japplphysiol.00075.2012.

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Whether neurogenic vasodilatation contributes to exercise hyperemia is still controversial. Blood flow to noncontracting muscle, however, is chiefly regulated by a neural mechanism. Although vasodilatation in the nonexercising limb was shown at the onset of exercise, it was unclear whether central command or muscle mechanoreflex is responsible for the vasodilatation. To clarify this, using voluntary one-legged cycling with the right leg in humans, we measured the relative changes in concentrations of oxygenated-hemoglobin (Oxy-Hb) of the noncontracting vastus lateralis (VL) muscle with near-in

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Kaczmarczyk, Karolina, Urszula Matuszewska, Wojciech Sajdak, et al. "THE IMPACT OF WINTER SWIMMING ON FUNCTIONAL MICROVASCULAR CHANGES." Journal of Hypertension 42, Suppl 1 (2024): e300-e301. http://dx.doi.org/10.1097/01.hjh.0001022632.25633.de.

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Objective: Microcirculation plays an important role in the development of cardiovascular control. Therefore, the aim of our study was to investigate the impact of winter swimming on functional changes in cutaneous microcirculation Flow-mediated skin fluorescence (FMSF) is a novel and non-invasive technique assessing microvascular function based on the measurements of nicotinamide adenine dinucleotide hydrogen (NADH) fluorescence intensity in the epidermis and post occlusive reactive hyperemia test. NADH intensity changes in response to blockage and release of blood flow in the brachial artery,

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Imberti, Roberto, Guido Bellinzona, and Martin Langer. "Cerebral tissue PO2 and SjvO2 changes during moderate hyperventilation in patients with severe traumatic brain injury." Journal of Neurosurgery 96, no. 1 (2002): 97–102. http://dx.doi.org/10.3171/jns.2002.96.1.0097.

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Object. The aim of this study was to investigate the effects of moderate hyperventilation on intracranial pressure (ICP), jugular venous oxygen saturation ([SjvO2], an index of global cerebral perfusion), and brain tissue PO2 (an index of local cerebral perfusion). Methods. Ninety-four tests consisting of 20-minute periods of moderate hyperventilation (27–32 mm Hg) were performed on different days in 36 patients with severe traumatic brain injury (Glasgow Coma Scale score ≤ 8). Moderate hyperventilation resulted in a significant reduction in average ICP, but in seven tests performed in five pa

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Terekhov, Serhii S., Andriy M. Proshchenko, Nina S. Proshchenko, and Dina V. Shorikova. "Clinical efficiency and stability of surface-modified implants: acid modification versus photoactivation." Polski Merkuriusz Lekarski 52, no. 1 (2024): 42–48. http://dx.doi.org/10.36740/merkur202401107.

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Aim: To study the stability of surface-modified dental implants, with the usage of sandblasting/acid modification vs. photoactivation. Materials and Methods: In the observation were included 164 patients with dental defects. All patients had digital impressions taken by scanning the oral cavity with an intraoral scanner 3Shape TRIOSR. Group A (80 subjects) included implants whose surface was modified with a combination of sandblasting and acid. Group B (84 subjects) - implants after modification with photoactivation. The implant stability quotient was recorded using an Osstell MentorTM device.

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Martínez, de la Casa JM, Bartolomé F. Pérez, E. Urcelay, et al. "Tear cytokine profile of glaucoma patients treated with preservative-free or preserved latanoprost." Ocul Surf 15, no. 4 (2017): 723–9. https://doi.org/10.1016/j.jtos.2017.03.004.

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<strong>Purpose: </strong>To determine variations in cytokine levels of glaucoma patients treated either with preservative-free latanoprost or preserved latanoprost, relative to healthy individuals. <strong>Methods: </strong>Tear samples were collected from 39 healthy subjects, 20 glaucoma patients treated with preserved latanoprost, and 20 patients treated with preservative-free latanoprost. A set of 27 inflammatory cytokines was analyzed in each group, including interleukin (IL)-1β, IL-1ra, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL9, IL-10, IL-12 (p70), IL-13, IL-15, IL-17, eotax

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Ladozhskaya-Gapeenko, E. E., K. N. Khrapov, Yu S. Polushin, I. V. Shlyk, N. N. Petrishchev, and I. V. Vartanova. "Microcirculation Disorders in Patients with Severe COVID-19." Messenger of ANESTHESIOLOGY AND RESUSCITATION 18, no. 4 (2021): 7–19. http://dx.doi.org/10.21292/2078-5658-2021-18-4-7-19.

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Impaired microcirculation due to endothelial dysfunction in COVID-19 is considered to be the most important link in the pathogenesis of this disease. However, due to the complexity of its instrumental assessment in critically ill patients, the data available in the literature on specific manifestations of endothelial dysfunction are very contradictory.The objective: to determine the most characteristic capillaroscopic signs of microvascular disorders and to assess the state of microcirculation regulation in patients with severe COVID-19.Subjects and Methods. When admitted to the intensive care

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Delaney, Kara M., Alexander Gorbach, Nitin Malik, et al. "Blood Flow Is Increased in Wounds and Peri-Wound Area by Laser Speckle Contrast Imaging and Infrared Thermography in Adults with Sickle Cell Leg Ulcers." Blood 120, no. 21 (2012): 1009. http://dx.doi.org/10.1182/blood.v120.21.1009.1009.

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Abstract Abstract 1009 Background: Leg ulcerations are a serious and debilitating complication of sickle cell disease (SCD) and other hemolytic anemias, whose etiology is not completely understood. Wound healing involves an ordered progression of vasoconstriction (hemostatic phase), followed by vasodilatation (inflammatory and proliferative phase) and epithelialization. Little is known about the changes in the microcirculation of chronic wounds in patients with sickle cell disease. Endothelial function affects microcirculation and regulates blood flow. Endothelial dysfunction is a recognized p

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Algranati, Dotan, Ghassan S. Kassab, and Yoram Lanir. "Flow restoration post revascularization predicted by stenosis indexes: sensitivity to hemodynamic variability." American Journal of Physiology-Heart and Circulatory Physiology 305, no. 2 (2013): H145—H154. http://dx.doi.org/10.1152/ajpheart.00061.2012.

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The expected blood flow improvement following a coronary intervention is inversely related to the stenotic-to-normal flow ratio Qs/Qn. Since Qn cannot be measured prior to intervention, treatment decisions rely on stenosis-severity indexes, e.g., area stenosis (%AS), hyperemic stenosis resistance (HSR), and fractional flow reserve (FFR), where treatment cut-off levels have been established for each index based on presence of inducible ischemia. Here, we studied the dependence of these indexes-predicted Qs/Qn under physiological perturbations of stenosis features and of hemodynamic and mechanic

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Banik, Sujoy, Girija Prasad Rath, Ritesh Lamsal, and Parmod K. Bithal. "Effect of dexmedetomidine on dynamic cerebral autoregulation and carbon dioxide reactivity during sevoflurane anesthesia in healthy patients." Korean Journal of Anesthesiology 73, no. 4 (2020): 311–18. http://dx.doi.org/10.4097/kja.19246.

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Background: There are conflicting opinions on the effect of dexmedetomidine on cerebral autoregulation. This study assessed its effect on dynamic cerebral autoregulation (dCA) using a transcranial Doppler (TCD).Methods: Thirty American Society of Anesthesiologists physical status I and II patients between 18 and 60 years, who underwent lumbar spine surgery, received infusions of dexmedetomidine (Group D) or normal saline (Group C), followed by anesthesia with propofol and fentanyl, and maintenance with oxygen, nitrous oxide and sevoflurane. After five minutes of normocapnic ventilation and sta

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Mahtab, Sana, Heather J. Zar, Ntobeko A. B. Ntusi, et al. "Endothelial Dysfunction in South African Youth Living With Perinatally Acquired Human Immunodeficiency Virus on Antiretroviral Therapy." Clinical Infectious Diseases 71, no. 10 (2020): e672-e679. http://dx.doi.org/10.1093/cid/ciaa396.

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Abstract Background Human immunodeficiency virus (HIV) and antiretroviral therapy (ART) confer cardiovascular disease (CVD) risk in adults with HIV. Few studies have assessed endothelial dysfunction (ED), an early marker of subclinical CVD risk, in youth living with perinatally acquired HIV (YLPHIV). Methods Using peripheral arterial tonometry, we compared ED in YLPHIV and age-matched youth without HIV. A reactive hyperemic index ≤1.35 was defined as ED. Eligible participants included those aged 9–14 years and on ART ≥6 months at enrollment. Results Overall, 431 YLPHIV and 93 youth without HIV

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Taysser, Zaytoun, Abdalla Amr, Beshay Bassem, Elbeheiry Ahmed, and Shebl Moustafa. "Evaluation of cerebral autoregulation using transcranial doppler ultrasound in patients with moderate and severe traumatic brain injuries." Biolife 5, no. 2 (2022): 155–63. https://doi.org/10.5281/zenodo.7361030.

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  <strong>ABSTRACT</strong> <strong>Introduction:</strong> Traumatic brain injury (TBI) has been increasing with greater incidence. It remains a leading cause of death. Cerebral pressure autoregulation impairment is a well-known pathology after TBI that worsens the prognosis and outcome. Transcranial Doppler (TCD) can be used to assess Transient Hyperaemic response ratio (THRR) after carotid compression which is a well demonstrated valid index for cerebral autoregulation. A relative increase in mean flow velocity (MFV) of middle cerebral artery (MCA) above the baseline following the relea

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Stacy, Mitchel R., Christopher M. Caracciolo, Prasanta Pal, Maolin Qiu, Smita Sampath, and Albert J. Sinusas. "Abstract 18596: Regional Assessment of Lower Extremity Tissue Oxygenation in Athletes Using Blood Oxygen Level-Dependent Magnetic Resonance Imaging." Circulation 128, suppl_22 (2013). http://dx.doi.org/10.1161/circ.128.suppl_22.a18596.

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Background: Blood oxygen level-dependent (BOLD) MRI allows for evaluation of hemoglobin oxygenation within skeletal muscle, providing a non-invasive index of microvascular function. This study evaluated differences in relative signal intensity of BOLD MRI among lower extremity muscle groups during transient ischemia and reactive hyperemia in college football athletes, while also comparing strength and functional exercise results. Methods: BOLD MRI was performed on the lower leg of 19 males (19.8 ± 1.0 yrs) with a 3T magnet to evaluate regional changes in signal intensity among individual muscl

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Andriopoulos, Georgios, Chris Kalogeropoulos, Andreas Katsanos, et al. "Quantitative assessment of chitin synthase gene of demodex mite on eyelashes and correlation to symptomatology of blepharitis." Acta Ophthalmologica 103, S284 (2025). https://doi.org/10.1111/aos.17220.

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Aims/Purpose: to quantify the presence and activity of Demodex mites and correlate it with patient symptoms, using quantitative determination of gene copy number for the chitin synthase gene.Methods: 61 patients meeting the inclusion criteria were enrolled in the study. 8 eyelashes from each patient were aseptically placed in sterile microtubes. After DNA isolation, quantitative real‐time PCR reactions were performed with specific primers for the chitin synthase gene (DEM) (for Demodex) and beta‐actin (ACTNB) and Factor V (FV) (for human), to amplify the corresponding genes. The quantitative d

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Bartlett, Miles F., Alberto Palmero-Canton, Andrew P. Oneglia, et al. "Epinephrine-Iontophoresis Attenuates Changes in Skin Blood Flow and Abolishes Cutaneous Contamination of NIR-DCS Estimations of Muscle Perfusion." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, January 24, 2023. http://dx.doi.org/10.1152/ajpregu.00242.2022.

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Near-infrared diffuse correlation spectroscopy (NIR-DCS) is an optical imaging technique for measuring relative changes in skeletal muscle microvascular perfusion (i.e., fold-change above baseline) during reactive hyperemia testing and exercise and is reported as a blood flow index (BFI). Although it is generally accepted that changes in BFI are primarily driven by changes in muscle perfusion, it is well-known that large, hyperthermia-induced changes in cutaneous blood flow can uncouple this relationship. What remains unknown, is how much of an impact that changes in cutaneous perfusion have o

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Gupta, Alok K., Eric Ravussin, Darcy L. Johannsen, April J. Stull, William T. Cefalu, and William D. Johnson. "Endothelial Dysfunction: An Early Cardiovascular Risk Marker in Asymptomatic Obese Individuals with Prediabetes." May 30, 2012. https://doi.org/10.5281/zenodo.7840.

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Aims: To elucidate if endothelial dysfunction is an early CV risk marker in obese men and women with prediabetes. Study Design: Cross-sectional study. Place and Duration of Study: Clinical Research Unit, Pennington Biomedical Research Center, Baton Rouge, LA. United States. Methodology: Overweight and obese status denotes an increasing adipose tissue burden which spills over into ectopic locations, including the visceral compartment, muscle and liver. Associated co-morbidities enhance cardiovascular (CV) risk. Endothelium which is the largest receptor-effector end-organ in our bodies, while re

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Fujisue, Koichiro, and Kenichi Tsujita. "Abstract 14476: A Randomized, Double-blind Comparison Study of Royal Jelly to Improve Endothelial Function in Healthy Volunteers." Circulation 142, Suppl_3 (2020). http://dx.doi.org/10.1161/circ.142.suppl_3.14476.

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Backgrounds: Royal jelly is a creamy substance secreted by honeybees. It has been reported that royal jelly has benefits on dyslipidemia and metabolic syndrome. However, the effects of royal jelly on atherogenesis remains unknown. We prospectively evaluated the effects of royal jelly on endothelial function, which can reflect early atherogenesis, in healthy volunteers. Methods: This was a single center, double-blind, 1:1 randomized placebo-controlled study. One-hundred healthy volunteers were randomly assigned to receive royal jelly 690 mg daily (equivalent 2040 mg of fresh royal jelly) or pla

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Chen, Yu, Pingting Chen, Ruinan Li, et al. "Rupture-related quantitative hemodynamics of the supratentorial arteriovenous malformation nidus." Journal of Neurosurgery, August 1, 2022, 1–10. http://dx.doi.org/10.3171/2022.6.jns212818.

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OBJECTIVE The hemodynamics of a brain arteriovenous malformation (AVM) nidus may be closely related to clinical presentation. The authors of this study aimed to explore the hemorrhagic quantitative hemodynamic indicators of the nidus through quantitative digital subtraction angiography (QDSA). METHODS The quantitative hemodynamic parameters were generated from QDSA. Three data sets were used to explore independent quantitative hemodynamic indicators associated with AVM rupture. The training data set was exploited to discover independent quantitative hemodynamic indicators of AVM rupture by per

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Rayner, Sophie E., Haoxuan Liu, Jennifer L. Petterson, Myles W. O'Brien, and Derek S. Kimmerly. "Investigating the relationship between aerobic fitness and lower-limb resistance vessel function before and after a bout of uninterrupted sitting." Applied Physiology, Nutrition, and Metabolism, March 27, 2025. https://doi.org/10.1139/apnm-2024-0365.

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Prolonged sitting reduces lower-limb resistance vessel function (RVF), whereas increasing aerobic fitness levels enhance lower-limb RVF. However, it is unknown if having higher aerobic fitness offers protection against prolonged sitting-induced declines in RVF. This study investigated the relationships between aerobic fitness versus reductions in lower-limb RVF following a 3-hour bout of uninterrupted sitting. In 30 healthy young to middle aged adults (19♀, 24±6 years), aerobic fitness was assessed during a graded, maximal cycling test. Relative peak oxygen consumption (V̇O2peak) was determine

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Yang, Xizi, Ziyu He, Ruizhi Hu та ін. "Dietary β-Carotene on Postpartum Uterine Recovery in Mice: Crosstalk Between Gut Microbiota and Inflammation". Frontiers in Immunology 12 (24 листопада 2021). http://dx.doi.org/10.3389/fimmu.2021.744425.

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As the precursor of vitamin A, β-carotene has a positive effect on reproductive performance. Our previous study has shown that β-carotene can increase antioxidant enzyme activity potentially through regulating gut microbiota in pregnant sows. This study aimed to clarify the effect of β-carotene on reproductive performance and postpartum uterine recovery from the aspect of inflammation and gut microbiota by using a mouse model. Twenty-seven 6 weeks old female Kunming mice were randomly assigned into 3 groups (n=9), and fed with a diet containing 0, 30 or 90 mg/kg β-carotene, respectively. The r

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Miguelez, Paula Rodriguez, Jeffrey Thomas, Nichole Seigler, Jennifer S. Pollock, and Ryan A. Harris. "MICROVASCULAR FUNCTION IS IMPAIRED IN ADULTS WHO REPORTED ADVERSE CHILDHOOD EVENTS." FASEB Journal 30, S1 (2016). http://dx.doi.org/10.1096/fasebj.30.1_supplement.948.6.

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INTRODUCTIONMicrovascular function, assessed using the cutaneous microcirculation, has been proposed as a prognostic marker of cardiovascular diseases (CVDs). Adversity early in life, referred to as adverse childhood events (ACEs), has been associated with the development of CVDs during adulthood. Whether or not microvascular dysfunction is present in adults who report ACEs has yet to be investigated.PURPOSEThis study sought to test the hypothesis that microvascular function is lower in adults who reported ACEs compared to adults who did not.METHODSNineteen young adults (33 ± 2 yrs), with no e

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Stewart, Kerry J., Pamela Ouyang, Harry A. Silber, et al. "Abstract MP011: Effect of a Low-Carbohydrate Versus a Low-Fat Weight Loss Program on Endothelial Function." Circulation 125, suppl_10 (2012). http://dx.doi.org/10.1161/circ.125.suppl_10.amp011.

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Background: A concern about low-carbohydrate (CHO) diets is that a higher fat intake may adversely affect vascular health. We hypothesized that the effect of two weight loss programs on endothelial function would be similar. Each program included exercise but differed in that one included a low-CHO diet whereas the other a low-fat diet. Methods: Overweight or obese but otherwise healthy persons (n=77), 30–65 years old, were randomly assigned to 6-months of an isocaloric low-CHO or low-fat diet, plus 3 times per week supervised aerobic and resistance exercise training. Endothelial function was

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Guedes de Sousa, Caio, José Maria Del Castillo, Carlos Mazzarollo, et al. "Comparative Analysis of the Coronary Arteries Flow Pattern in Secondary Myocardial Hypertrophies and by Sarcomeric Mutation." ABC Imagem Cardiovascular 34, no. 1 (2021). http://dx.doi.org/10.47593/2675-312x/20213401eabc131.

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Background: Coronary flow with a diastolic predominance increases two to five times in hyperemia, mediated by vasodilation (coronary flow reserve, CFR) and, in hypertrophy, relative ischemia may occur. In secondary hypertrophy (LVH), the flow, normal at rest, becomes ischemic due to increased demand. In hypertrophic cardiomyopathy (HCM) with perivascular fibrosis, collateral vessels appear to increase the irrigation of hypertrophied segments. Objective: To determine the coronary flow pattern in patients with secondary hypertrophy and hypertrophic cardiomyopathy,evaluating the coronary flow res

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Desanlis, Julien, Dan Gordon, Chloe French, Camille Calveyrac, François Cottin, and Marie Gernigon. "Effects of occlusion pressure on hemodynamic responses recorded by near-infrared spectroscopy across two visits." Frontiers in Physiology 15 (September 11, 2024). http://dx.doi.org/10.3389/fphys.2024.1441239.

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Ischemic Preconditioning (IPC) has emerged as a promising approach to mitigate the impact of hypoxia on physiological functions. However, the heterogeneity of occlusion pressures for inducing arterial occlusion has led to inconsistent hemodynamic outcomes across studies. This study aims to evaluate the peripheral hemodynamic responses to partial and total blood-flow occlusions on the left arm at rest, using absolute or individualized pressures, on two occasions. Thirty-five young males volunteered to participate in this study. IPC procedure (3 × 7-min) was performed on the left upper arm with

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Sigurðardóttir, Ylfa Rún, Bylgja Rún Stefánsdóttir, Thor Aspelund, et al. "Endothelial function assessed by peripheral arterial tonometry is not related to cardiovascular risk score in healthy subjects." International Cardiovascular Forum Journal 9 (January 14, 2017). http://dx.doi.org/10.17987/icfj.v9i0.385.

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<p><span style="font-size: medium;"><strong>Background: </strong>The majority of first cases of myocardial infarction stem from those classified as intermediate- or low-risk in CV risk prediction calculators. Risk prediction models need to be refined in their capacity to discriminate high-risk from low-risk. Peripheral arterial tonometry (PAT) is a non-invasive method to assess peripheral endothelial function that could potentially improve primary prevention of CVD. We investigated the relation of PAT results to CV risk factors and risk score in a healthy cohort.</sp

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Stewart, Kerry J., Devon A. Dobrosielski, Harry A. Silber, Edward P. Shapiro, Nae-Yuh Wang, and Pamela Ouyang. "Abstract 18552: Six Months of a Low-Carbohydrate versus Low-Fat Weight Loss Diet Plus Exercise: Effects on Resting and Postprandial Endothelial Function." Circulation 128, suppl_22 (2013). http://dx.doi.org/10.1161/circ.128.suppl_22.a18552.

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Background: A worry about low-carbohydrate (CHO) diets is that higher fat meals may adversely affect vascular function acutely, and the regular eating of such meals may lead to chronic vascular impairment. We hypothesized that the effects of a low-CHO vs. low-fat weight loss diet, each combined with exercise training for 6-months, would have similar effects on resting and postprandial endothelial function. Methods: Persons (n=77), BMI 25-42 kg/m2, 30-65 years, were randomly assigned to a low-CHO or low-fat diet, plus exercise. At 0 and 6 months, reactive hyperemia was induced after 5 minutes o

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do Amaral Henrique de Souza, Ana Carolina, Filipe A. Moura, Sanjay Divakaran, et al. "Abstract 18949: Bariatric Surgery is Associated With Improved Coronary Microvascular Function and Cardiorespiratory Fitness in Patients With Ischemia and Non-Obstructive Coronary Arteries (INOCA)." Circulation 148, Suppl_1 (2023). http://dx.doi.org/10.1161/circ.148.suppl_1.18949.

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Introduction - Severe obesity is associated with cardiometabolic disease and coronary microvascular dysfunction, as reflected by impaired coronary flow reserve (CFR). Bariatric surgery promotes sustained weight loss and lower incidence of diabetic microvascular complications, but its effect on the coronary microcirculation is unclear. In this ongoing pilot study, we aimed to investigate the impact of bariatric surgery on CFR, endothelial function, and cardiorespiratory fitness in patients with severe obesity and INOCA. Methods - Consecutive patients (N=19) with severe obesity (BMI≥35 kg/m 2 ),

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Gomez, Alwyn, Mypinder Sekhon, Donald Griesdale, et al. "Cerebrovascular pressure reactivity and brain tissue oxygen monitoring provide complementary information regarding the lower and upper limits of cerebral blood flow control in traumatic brain injury: a CAnadian High Resolution-TBI (CAHR-TBI) cohort study." Intensive Care Medicine Experimental 10, no. 1 (2022). http://dx.doi.org/10.1186/s40635-022-00482-3.

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Abstract Background Brain tissue oxygen tension (PbtO2) and cerebrovascular pressure reactivity monitoring have emerged as potential modalities to individualize care in moderate and severe traumatic brain injury (TBI). The relationship between these modalities has had limited exploration. The aim of this study was to examine the relationship between PbtO2 and cerebral perfusion pressure (CPP) and how this relationship is modified by the state of cerebrovascular pressure reactivity. Methods A retrospective multi-institution cohort study utilizing prospectively collected high-resolution physiolo

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Rodriguez, Cesar, Santh Prakash Lanka, Joshua Maraj, et al. "Abstract 4146883: Analysis of Near-Infrared Spectroscopy Vascular Occlusion Test as a Complement to Ankle-Brachial Index and 6-Minute Walk Test in Patients Diagnosed with Peripheral Artery Disease." Circulation 150, Suppl_1 (2024). http://dx.doi.org/10.1161/circ.150.suppl_1.4146883.

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Introduction: Peripheral arterial disease (PAD) is caused by a lack of blood flow to the musculature relative to its metabolism which results in pain. PAD impacts up to 20% of patients around the world. PAD involves macrovascular and microvascular dysfunction. Near-infrared spectroscopy (NIRS) measures muscle oxygenation levels and assesses microvascular function. The standard of care for diagnosing PAD is the ankle-brachial index (ABI), which assesses macrovascular disease, and the 6-minute walk test (6MWT), which measures gait speed and claudication. NIRS has the potential to monitor progres

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Folwarczny, Elisabeth, Felix Forster, Rudolf A. Jörres, et al. "Acute health effects of ambient air pollution including ultrafine particles in a semi-experimental setting in young, healthy individuals." Particle and Fibre Toxicology 22, no. 1 (2025). https://doi.org/10.1186/s12989-025-00628-7.

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Abstract Background Multiple effects of ultrafine particles (UFP) on human subjects are known but there is less knowledge of how relative exposure levels between ultrafine and fine particles as typically encountered in large cities affect lung function and cardiovascular parameters. Methods Four sites with high/low levels of ultrafine particles and/or fine particles were selected in the city of Munich, Germany: control area (woodland), urban environment, heavy traffic site, biomass combustion (beech wood). In a randomized cross-over design, 26 young, healthy individuals were exposed at each si

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Tahsin, Chowdhury Tasnova, Jeanie Park, Kathryn Cullen, et al. "Sleep quality and PTSD symptoms predict vascular dysfunction in young, trauma-exposed women." Physiology 38, S1 (2023). http://dx.doi.org/10.1152/physiol.2023.38.s1.5726898.

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Introduction: Cardiovascular disease (CVD) remains the leading cause of death among women in the United States. Although premenopausal women are thought to be protected from CVD, trauma exposure increases their CVD risk. Poor sleep – a CVD risk factor – is common after trauma exposure. Further, accumulating evidence suggests that vascular dysfunction is independently associated with CVD. However, the link between sleep and vascular function in otherwise healthy, trauma-exposed young women is not known. Therefore, the purpose of the present study was to investigate the individual and combined e

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Patik, Jordan C., Justin D. Mehrer, Serena A. Schade, et al. "Sodium Loading Does Not Induce Oxidative Stress-Mediated Reductions in Vascular Function in Young Adults." Physiology 39, S1 (2024). http://dx.doi.org/10.1152/physiol.2024.39.s1.2580.

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Short-term, high sodium diets decrease dilation responses in conduit arteries and the microvasculature when compared to low sodium diets (e.g., 7000 vs. 500 mg/day). Supraphysiological antioxidant treatment mitigates these effects supporting a role for oxidative stress in sodium-induced vascular impairments. It is unclear whether these effects are present when high sodium conditions are compared to the sodium level of a typical American diet (~3400 mg/day). Therefore, we tested the hypotheses that sodium added to the habitual diet of young adults would reduce flow mediated dilation (FMD) and p

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Shah, Prarthi J., John O. Kolade, Alison Ortiz, Ken A. Perry, and R. Matthew Brothers. "The impact of increased daily peanut consumption on indices of peripheral and cerebral vascular function in non-Hispanic Black individuals." Physiology 39, S1 (2024). http://dx.doi.org/10.1152/physiol.2024.39.s1.982.

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Cardiovascular disease, neurocognitive conditions, and cerebral vascular diseases including cognitive impairment, stroke, and Alzheimer’s disease and related dementias disproportionately impact the Non-Hispanic Black (BL) population. The mechanisms are multifactorial but is related to reduced vascular function/health. Our lab, and others, have demonstrated that reduced nitric oxide (NO) bioavailability secondary to oxidative stress, systemic inflammation, and reduced L-arginine bioavailability contributes to reduced vascular function/health in this population. Increased dietary peanut consumpt

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Adler, Tessa E., Charlotte W. Usselman, Laura C. Anaeto, et al. "Relationship between body mass index and endothelial dysfunction in women with and without polycystic ovary syndrome." FASEB Journal 31, S1 (2017). http://dx.doi.org/10.1096/fasebj.31.1_supplement.691.8.

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The flow‐mediated dilation test is a clinical index of endothelial health. Polycystic ovary syndrome (PCOS) is the most common reproductive endocrinopathy affecting ~1 in 10 women of reproductive age. Women with PCOS are at risk for endothelial dysfunction, so we hypothesized that they would have a blunted flow‐mediated dilation (FMD) response relative to controls. We tested 4 women diagnosed with PCOS according to the Rotterdam criteria (age: 30 (6) y, BMI: 26.7 (8.3) kg/m2, range 21.3–40.0 kg/m2) and 4 similarly aged controls (age: 27 (9) y, BMI: 27.6 (9.2) kg/m2, range 18.9–40.2 kg/m2). To

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Barok, Rebecca, Dylan Kissane, David Emmela, Danny Hammo, Ho-Sheng Lin, and Jason Mateika. "Repeated Exposure to Mild Intermittent Hypoxia Improves Walking Endurance in OSA Patients for 4 - 8 Weeks Post Therapy." Physiology 39, S1 (2024). http://dx.doi.org/10.1152/physiol.2024.39.s1.1189.

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Background: Approximately one billion adults globally are diagnosed with obstructive sleep apnea (OSA). Co-morbidities associated with sleep apnea include hypertension and increased susceptibility to fatigue linked to lower oxygen bioavailability and reduced exercise performance. Previously, we reported that daily exposure to mild intermittent hypoxia (MIH) reduces blood pressure following 3 weeks of treatment. These reductions in pressure could be coupled with improvements in microvascular function, fatigability and exercise performance. Objective: Thus, in the present investigation we explor

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von Känel, Roland, Mary Princip, Sarah A. Holzgang, et al. "Association between global sleep quality and coronary microvascular function in male physicians with occupational burnout." Psychosomatic Medicine, November 17, 2023. http://dx.doi.org/10.1097/psy.0000000000001269.

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ABSTRACT Objective Occupational burnout has been associated with an increased risk of coronary heart disease, although the mechanisms involved are elusive. We investigated whether poor global sleep quality is associated with impaired coronary microvascular function in male physicians, a professional group at increased risk for burnout. Methods Study participants were 30 male physicians with clinical burnout and 30 controls without burnout defined by the Maslach Burnout Inventory. Global sleep quality was measured with the Pittsburgh Sleep Quality Index (PSQI). Endothelium-dependent (cold press

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Hurr, Chansol, Jordan C. Patik, Kevin M. Christmas, and R. Matthew Brothers. "Tempol Augments the Blunted Cutaneous Microvascular Thermal Reactivity in Healthy Young African Americans." FASEB Journal 30, S1 (2016). http://dx.doi.org/10.1096/fasebj.30.1_supplement.763.16.

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African Americans (AA) have a higher risk for a variety of cardiovascular and metabolic diseases including hypertension, stroke, peripheral artery disease, and type 2 diabetes mellitus when compared with Caucasian Americans (CA). While this elevated risk is multifactorial impaired vascular endothelial function is a contributing factor. In this study, we hypothesized that cutaneous hyperemic response to a standard local heating protocol is reduced in young AA when compared with CA. We further hypothesized that tempol (a superoxide dismutase mimetic) would increase this cutaneous vasodilatory re

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Rossman, Matthew J., H. Jonathan Groot, Ryan S. Garten, Melissa Witman, and Russell Richardson. "Vascular Function Assessed by Passive Leg Movement and Flow‐Mediated Dilation: Evidence of Construct Validity." FASEB Journal 30, S1 (2016). http://dx.doi.org/10.1096/fasebj.30.1_supplement.945.5.

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The vasodilatory response to passive leg movement (PLM), often performed in either the upright seated or supine posture, appears to provide a novel, non‐invasive assessment of vascular function. However, PLM has yet to be compared to flow mediated vasodilation (FMD), a test recognized to have prognostic value in terms of vascular health. Therefore, to evaluate the construct validity of PLM, brachial (BA) and superficial femoral (SFA) artery FMDs (Doppler ultrasound) and upright seated and supine PLM were performed in 10 young (22±1) and 10 old (72±2) subjects. During PLM, leg blood flow (LBF,

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