Relevant bibliographies by topics / Relative insulin potency

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Academic literature on the topic 'Relative insulin potency'

Author: Grafiati
Published: 3 June 2025
Last updated: 31 July 2025

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Journal articles on the topic "Relative insulin potency"

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Bindu, Rama Bhat, Girish, and Krishna Prasad. "RELATIVE POTENCY OF ANTI-DIABETIC COSTUS SPECIOSUSPLANT EXTRACT IN MOUSE FIBROBLAST CELL LINE." International Journal of Research -GRANTHAALAYAH 4, no. 3 (2016): 99–107. http://dx.doi.org/10.29121/granthaalayah.v4.i3.2016.2790.

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Plant-derived compounds have been used clinically to treat type 2 diabetes for many years as they also exert additional beneficial effects on various other disorders. PI3K pathway is the major pathway activated by insulin receptor (IR). It induces glucose uptake, glycogen synthesis, protein synthesis, cell growth and differentiation. Hence metabolic assay was employed to assess glucose uptake based on the property of 3T3-L 1 cells to differentiate into adipocytes which can take up the glucose in medium due to the effect of insulin or insulin like molecules. The results of the current study sho
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C, Bindu, Rama Bhat P., Krishna Prasad G., and C. Girish B. "RELATIVE POTENCY OF ANTIDIABETIC EFFECT OF COSTUS SPECIOSUS (KOEN. EX RETZ.) SMITH PLANT EXTRACT IN MOUSE FIBROBLAST CELL LINE." International Journal of Research – Granthaalayah 4, no. 3 (2017): 99–106. https://doi.org/10.5281/zenodo.847009.

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Plant-derived compounds have been used clinically to treat type 2 diabetes for many years as they also exert additional beneficial effects on various other disorders. PI3K pathway is the major pathway activated by insulin receptor (IR). It induces glucose uptake, glycogen synthesis, protein synthesis, cell growth and differentiation. Hence metabolic assay was employed to assess glucose uptake based on the property of 3T3-L1 cells to differentiate into adipocytes which can take up the glucose in medium due to the effect of insulin or insulin like molecules. The results of the current research s
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Bajaj, M., T. L. Blundell, R. Horuk, et al. "Coypu insulin. Primary structure, conformation and biological properties of a hystricomorph rodent insulin." Biochemical Journal 238, no. 2 (1986): 345–51. http://dx.doi.org/10.1042/bj2380345.

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Insulin from a hystricomorph rodent, coypu (Myocaster coypus), was isolated and purified to near homogeneity. Like the other insulins that have been characterized in this Suborder of Rodentia, coypu insulin also exhibits a very low (3%) biological potency, relative to pig insulin, on lipogenesis in isolated rat fat-cells. The receptor-binding affinity is significantly higher (5-8%) in rat fat-cells, in rat liver plasma membranes and in pig liver cells, indicating that the efficacy of coypu insulin on receptors is about 2-fold lower than that of pig insulin. The primary structures of the oxidiz
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Chrudinová, Martina, Lenka Žáková, Aleš Marek, et al. "A versatile insulin analog with high potency for both insulin and insulin-like growth factor 1 receptors: Structural implications for receptor binding." Journal of Biological Chemistry 293, no. 43 (2018): 16818–29. http://dx.doi.org/10.1074/jbc.ra118.004852.

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Insulin and insulin-like growth factor 1 (IGF-1) are closely related hormones involved in the regulation of metabolism and growth. They elicit their functions through activation of tyrosine kinase–type receptors: insulin receptors (IR-A and IR-B) and IGF-1 receptor (IGF-1R). Despite similarity in primary and three-dimensional structures, insulin and IGF-1 bind the noncognate receptor with substantially reduced affinity. We prepared [d-HisB24, GlyB31, TyrB32]-insulin, which binds all three receptors with high affinity (251 or 338% binding affinity to IR-A respectively to IR-B relative to insuli
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5

Richardson, S. B., T. Laya, and M. VanOoy. "Similarities between hamster pancreatic islet beta (HIT) cell vasopressin receptors and V1b receptors." Journal of Endocrinology 147, no. 1 (1995): 59–65. http://dx.doi.org/10.1677/joe.0.1470059.

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Abstract Vasopressin (VP) elicits almost identical insulin-stimulatory dose responses in isolated mouse islets and hamster β (HIT) cells. We have further pharmacologically characterized HIT cell VP receptors by comparing the potencies of a series of VP agonists including the novel V1b agonist, desamino(d-3-(3′-pyridyl)-Ala2,Arg8)VP (d(d-3-Pal)VP), in stimulating insulin secretion and inositol phosphate (IP) production. The relative orders of potency of VP analogues were parallel in both respects: desamino-Arg-VP (dAVP)>Arg-vasotocin (AVT)= VP>oxytocin (OXY)>desamino-d-Arg-VP (ddAVP)&g
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Molano, Ruth Damaris, Antonello Pileggi, Hubert M. Tse, Cherie L. Stabler, and Christopher A. Fraker. "A static glucose-stimulated insulin secretion (sGSIS) assay that is significantly predictive of time to diabetes reversal in the human islet bioassay." BMJ Open Diabetes Research & Care 12, no. 2 (2024): e003897. http://dx.doi.org/10.1136/bmjdrc-2023-003897.

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IntroductionStatic incubation (static glucose-stimulated insulin secretion, sGSIS) is a measure of islet secretory function. The Stimulation Index (SI; insulin produced in high glucose/insulin produced in low glucose) is currently used as a product release criterion of islet transplant potency.Research design and methodsOur hypothesis was that the Delta, insulin secreted in high glucose minus insulin secreted in low glucose, would be more predictive. To evaluate this hypothesis, sGSIS was performed on 32 consecutive human islet preparations, immobilizing the islets in a slurry of Sepharose bea
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Vienberg, Sara G., Stephan D. Bouman, Heidi Sørensen, et al. "Receptor-isoform-selective insulin analogues give tissue-preferential effects." Biochemical Journal 440, no. 3 (2011): 301–8. http://dx.doi.org/10.1042/bj20110880.

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The relative expression patterns of the two IR (insulin receptor) isoforms, +/− exon 11 (IR-B/IR-A respectively), are tissue-dependent. Therefore we have developed insulin analogues with different binding affinities for the two isoforms to test whether tissue-preferential biological effects can be attained. In rats and mice, IR-B is the most prominent isoform in the liver (>95%) and fat (>90%), whereas in muscles IR-A is the dominant isoform (>95%). As a consequence, the insulin analogue INS-A, which has a higher relative affinity for human IR-A, had a higher relative potency [compare
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8

Shibasaki, Y., H. Sakura, M. Odawara, et al. "Glucocorticoids increase insulin binding and the amount of insulin-receptor mRNA in human cultured lymphocytes." Biochemical Journal 249, no. 3 (1988): 715–19. http://dx.doi.org/10.1042/bj2490715.

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The effect of steroid hormones on insulin binding and the amount of insulin-receptor mRNA was examined in IM-9 lymphocytes. Cortisol and cortexolone, but not oestrogen, increased both the binding of insulin and the amount of insulin-receptor mRNA in a time- and dose-dependent manner. Cortisol was most potent, and induced a 2-fold increase in insulin binding and a 4-fold increase in mRNA. The elevation in binding was due to an increased number of insulin receptors at the cell surface. The increase in mRNA involved all four of the insulin-receptor mRNAs and could not be inhibited by cycloheximid
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9

Tang, J., W. Pugh, K. S. Polonsky, and H. Zhang. "Preservation of insulin secretory responses to P2 purinoceptor agonists in Zucker diabetic fatty rats." American Journal of Physiology-Endocrinology and Metabolism 270, no. 3 (1996): E504—E512. http://dx.doi.org/10.1152/ajpendo.1996.270.3.e504.

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The role of P2 purinoceptor agonists in regulatory insulin secretion in Zucker diabetic fatty (ZDF) rats was studied using the isolated perfused pancreas and intracellular Ca2+ concentration ([Ca2+]i) microfluorimetry. The relative potency of different purinoceptor agonists to stimulate the insulin secretory process was consistent with the conclusion that responses in [Ca2+]i and insulin secretion are mediated by the P2y subtype of purinoceptors. Additional studies using specific antagonists of the Ca2+ signaling pathway indicated that activation of P2y purinoceptor releases Ca2+ from intracel
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10

Jonas, H. A., and A. J. Cox. "Insulin-like growth factor binding to the atypical insulin receptors of a human lymphoid-derived cell line (IM-9)." Biochemical Journal 266, no. 3 (1990): 737–42. http://dx.doi.org/10.1042/bj2660737.

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The cells of the IM-9 human lymphocyte-derived line contain a sub-population of insulin-binding sites whose immunological and hormone-binding characteristics closely resemble those of the atypical insulin-binding sites of human placenta. These binding sites, which have moderately high affinity for multiplication-stimulating activity [MSA, the rat homologue of insulin-like growth factor (IGF) II] and IGF-I, are identified on IM-9 cells by 125I-MSA binding. They account for approximately 30% of the total insulin-receptor population, and do not react with a monoclonal antibody to the type I IGF r
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Book chapters on the topic "Relative insulin potency"

1

Kinch, Michael. "Dreams of Greatness." In Prescription for Change. University of North Carolina Press, 2016. http://dx.doi.org/10.5149/northcarolina/9781469630625.003.0004.

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This chapter details the birth of the pharmaceutical industry, whose roots trace back more than six millennia. While modern society struggles with opiate addiction, the problem is centuries old and fostered a literal trade war in the form of the Opium Wars of the 19<sup>th</sup> century and whose scars still muddle international relations of China with the West today. During this same time period, improvements in understanding opium facilitated the discovery of new and more potent products that nurtured modern companies such as Merck &amp; Co. Perhaps no other discovery has impacted the indust
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