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Dissertations / Theses on the topic 'Relative sensitivity'
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1
Martin, Derek. "The relative sensitivity of algae to inhibitors from plant litter." Thesis, n.p, 1999. http://ethos.bl.uk/.
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Emberson, Lisa Dianne. "Defining and mapping relative potential sensitivity of European vegetation to ozone." Thesis, Imperial College London, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.312278.
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Mathai, Kalapurackal Robins. "Sensitivity analysis of relative worth in empirical and simulation-based QFD matrices." Diss., Rolla, Mo. : Missouri University of Science and Technology, 2008. http://scholarsmine.mst.edu/thesis/pdf/Mathai_Kalapurackal_09007dcc8057a197.pdf.
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Thesis (M.S.)--Missouri University of Science and Technology, 2008.<br>Vita. The entire thesis text is included in file. Title from title screen of thesis/dissertation PDF file (viewed January 15, 2009) Includes bibliographical references (p. 51-52).
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Kamath, Vidyulata. "THE RELATIVE SENSITIVITY OF AN OLFACTORY IDENTIFICATION DEFICIT IN INDIVIDUALS WITH SCHIZOTYPAL PERSONALITY FEATURES." Master's thesis, University of Central Florida, 2007. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/3847.
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Olfactory identification deficits have received recent attention as a potentially useful endophenotype for schizophrenia. Examination of this deficit in individuals with schizotypal personality features (SPF) offers an alternative approach to multiple confounds present when examining individuals with schizophrenia. The aim of the current study was to compare the relative sensitivity of performance on measures of olfaction identification and sustained attention to the presence of SPF. Twenty-six undergraduates were defined as having SPF based on scoring in the top 10% of the Abbreviated Schizotypal Personality Questionnaire (SPQ-B; mean age 19.6, SD = 1.1; 62% female). These individuals were compared to twenty-six controls (scoring lower than half a standard deviation above the mean; mean age 19.8, SD = 1.6; 62% female). All participants were administered the Schizotypal Personality Disorder (SPD) section of the Structured Clinical Interview for DSM IV Axis II Personality Disorders (SCID-II). In addition, participants were administered the Brief Smell Identification Test (B-SIT) and a six-minute degraded-stimuli Continuous Performance Test (CPT). Group differences in performance indices of the CPT did not approach statistical significance. Similarly, there were no statistically significant group differences for males or females in performance on the B-SIT. Correlational analyses examined cognitive performance with a dimension score derived by summing quantitative ratings from the SPD items on the SCID-II. The SPD dimension score showed a statistically significant positive correlation with several performance indices of the CPT, including omission errors (rs(52) = .51, p < .001) and commission errors (rs(52) = .38, p < .005). In contrast, the B-SIT scores were not correlated with the SPD dimension score for males or females. Contrary to our hypothesis, results from the current study suggest that olfactory identification deficits may not represent a robust endophenotype consistently found in samples with schizotypal personality features. With regard to sustained attention, our differential findings suggest that schizotypal traits may be more adequately assessed through an interview by trained clinicians who use clinical judgment to determine the presence of phenotypic aspects of SPD (e.g., SCID-II), rather than relying on self-report measures (e.g., SPQ-B). Implications as well as limitations and future directions of these findings are discussed.<br>M.S.<br>Department of Psychology<br>Sciences<br>Psychology PhD
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Blackburn, Dane E. "A novel approach to calculating relative scattering parameter sensitivity in computer-aided design programs." Thesis, Virginia Polytechnic Institute and State University, 1988. http://hdl.handle.net/10919/80100.
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Relative sensitivity is a measure of the percentage change in a system parameter caused by a percentage change in a component parameter. The adjoint network method has previously been used by Monaco and Tiberio in the computation of relative scattering parameter sensitivity. A new approach is presented in this work which defines a bilinear equation and three constants that relate any component scattering parameter to any system scattering parameter. A computer-aided design program which implements this relative sensitivity in analysis and optimization is presented. Circuit analysis examples demonstrating sensitivity analysis and optimization are included. As a background for this work, computer-aided design concepts, such as network modeling, objective functions, Rosenbrock's optimization method, and the adjoint network method for estimating partial derivatives, are also presented.<br>Master of Science
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Rixey, Caitlin. "Equilibrium Climate Sensitivity and the Relative Weightings of Various Climate Forcings on Local Temperature Records." Thesis, Boston College, 2015. http://hdl.handle.net/2345/bc-ir:104028.
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Thesis advisor: Jeremy Shakun<br>As recently measured amounts of global atmospheric carbon dioxide concentrations have risen 40% from pre-Industrial levels and will likely reach double by mid-century, climate scientists have expressed concern over the future state of the climate system, and have attempted to gauge the consequences of such a large forcing. The principal parameter for climate scientists is equilibrium climate sensitivity, which is the change in temperature following a doubling of atmospheric CO2 concentrations. Current estimates of climate sensitivity span too expansive of a range to provide a clear understanding of the magnitude of temperature changes one can expect. Therefore, I conduct many individual multivariate analyses as a means of narrowing these ranges of sensitivity and to investigate geographical distributions of sensitivity, at the very least. To do so, I analyze four major climate forcings: greenhouse gas, atmospheric dust, ice volume, and insolation. Using several multiple linear regressions, I calculate the relative weighting of each forcing in driving the temperature signal in 47 local temperature proxy records. The paleoclimate proxy records chosen span glacial cycles over the past 800 kyr. These results provide insight into the geographical distributions of the relative influences of each of the forcings, while working to constrain the range of sensitivity estimates through the weighting of the greenhouse gas forcing. Separating out the individual climate inputs allows me to conclude what percentage of climate change was caused by CO2 in the past, and by implication how much warming might be expected due to GHG forcing in the future<br>Thesis (BS) — Boston College, 2015<br>Submitted to: Boston College. College of Arts and Sciences<br>Discipline: Earth and Environmental Sciences
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Jones, Catherine. "The road to maternal responsiveness is paved with good intentions : an investigation into the relative effects of breastfeeding intention and practice on observed maternal responsiveness after birth." Thesis, University of Exeter, 2013. http://hdl.handle.net/10871/14128.
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Objective: The aim of this study was to investigate the differential effects of breastfeeding practice and having an intention to breastfeed (during pregnancy) on a mother’s maternal responsiveness to her infant after birth. Methods: Using longitudinal data from a subsample of 962 mother-infant dyads from a UK cohort study (Avon Longitudinal Study of Parents and Children), we investigated the influence of intention to breastfeed at 3 months pregnancy and breastfeeding practice and on mother-infant interactions at 12 months after birth. Breastfeeding intent and practice were assessed by questionnaires administered to the mothers. Intention to breastfeed in the first 3 months postpartum was measured at 32 weeks into the pregnancy, while breastfeeding practice (over first 12 months postpartum) was measured retrospectively at 15 months post partum. Results: Using logistic regression analyses, we found that intending to breastfeed at 32 weeks gestation significantly predicted maternal responsiveness, namely that an intention to breastfeed increased the odds of positive maternal responsiveness, independently of breastfeeding practice. However, we found the practice of breastfeeding was not an independent predictor of positive maternal responsiveness once intention to breastfeed was accounted for. Using a life course epidemiology approach we further demonstrated that maternal responsiveness is most positive when both the intention to breastfeed and breastfeeding practice are present. Conclusions: To our knowledge this is the first study to report that having the intention to breastfeed an infant is more strongly associated with positive maternal responsiveness than the act of breastfeeding itself. This may suggest that more responsive mothers choose to breastfeed rather than breastfeeding practice directly causing enhanced responsiveness. Further research will be needed to understand the nature of this intention and its relationships with maternal responsiveness. However, the results may also highlight the potential importance of parenting intentions/ preparations during pregnancy for a mothers developing abilities to be responsive to her infant after birth.
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Cutillas, Mireia Pacheco. "The relative loss of chromatic and achromatic sensitivity in primary open angle glaucoma and the normal ageing process." Thesis, City University London, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.418961.
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Lessios, Nicolas. "Using electroretinograms and multi-model inference to identify spectral classes of photoreceptors and relative opsin expression levels." PEERJ INC, 2017. http://hdl.handle.net/10150/625519.
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Understanding how individual photoreceptor cells factor in the spectral sensitivity of a visual system is essential to explain how they contribute to the visual ecology of the animal in question. Existing methods that model the absorption of visual pigments use templates which correspond closely to data from thin cross-sections of photoreceptor cells. However, few modeling approaches use a single framework to incorporate physical parameters of real photoreceptors, which can be fused, and can form vertical tiers. Akaike’s information criterion (AIC
c
) was used here to select absorptance models of multiple classes of photoreceptor cells that maximize information, given visual system spectral sensitivity data obtained using extracellular electroretinograms and structural parameters obtained by histological methods. This framework was first used to select among alternative hypotheses of photoreceptor number. It identified spectral classes from a range of dark-adapted visual systems which have between one and four spectral photoreceptor classes. These were the velvet worm,
Principapillatus hitoyensis
, the branchiopod water flea,
Daphnia magna
, normal humans, and humans with enhanced S-cone syndrome, a condition in which S-cone frequency is increased due to mutations in a transcription factor that controls photoreceptor expression. Data from the Asian swallowtail,
Papilio xuthus
, which has at least five main spectral photoreceptor classes in its compound eyes, were included to illustrate potential effects of model over-simplification on multi-model inference. The multi-model framework was then used with parameters of spectral photoreceptor classes and the structural photoreceptor array kept constant. The goal was to map relative opsin expression to visual pigment concentration. It identified relative opsin expression differences for two populations of the bluefin killifish,
Lucania goodei
. The modeling approach presented here will be useful in selecting the most likely alternative hypotheses of opsin-based spectral photoreceptor classes, using relative opsin expression and extracellular electroretinography.
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Dancer, Sumari Constance. "Sensitivity and specificity of thoracic radiography relative to computed tomography in dogs affected by blunt trauma caused by a motor vehicle accident." Diss., University of Pretoria, 2019. http://hdl.handle.net/2263/77395.
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Thoracic injuries caused by blunt trauma are commonly encountered emergencies in veterinary medicine. However, no literature exists comparing radiography to computed tomography (CT) in blunt thoracic trauma caused by motor vehicle accidents in canine patients. The aim of this prospective case series was to estimate the sensitivity (Se) and specificity (Sp) of thoracic radiography relative to CT for detecting lung contusions, pneumothorax, pleural effusion and rib fractures. The study further aimed to establish a severity scoring system for radiography and CT and to compare the findings between the two modalities. The hypothesis was that radiography would be less sensitive than CT at detecting these injuries and that radiography would underestimate the severity of lung contusions compared to CT. Fifty-nine patients met the inclusion criteria. Radiography underestimated the presence of lung contusions (Se = 69%, 95% Confidence interval (CI)) and overestimated the severity of the contusions relative to CT. There was also high interobserver variability in evaluating lung contusion severity (coefficient of variation = 91%). Both the three-view thoracic and horizontal beam radiography had poor sensitivities for the detection of pneumothorax (Se = 19% and 63% respectively) and pleural effusions (Se = 43% and 71% respectively). Similarly, the sensitivity (56%) of three-view thoracic radiographs for the detection of rib fractures was poor relative to CT. To conclude, three-view thoracic radiography had low sensitivity for pathology related to blunt thoracic trauma caused by motor vehicle accidents and CT could be considered as an additional diagnostic imaging modality in these patients.<br>Dissertation (MMedVet (Diagnostic Imaging))--University of Pretoria, 2019.<br>Companion Animal Clinical Studies<br>MMedVet (Diagnostic Imaging)<br>Unrestricted
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Field, James G. "A SENSITIVITY ANALYSIS FOR RELATIVE IMPORTANCE WEIGHTS IN THE META-ANALYTIC CONTEXT: A STEP TOWARDS NARROWING THE THEORY-EMPIRICISM GAP IN TURNOVER." VCU Scholars Compass, 2017. http://scholarscompass.vcu.edu/etd/4734.
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Turnover is one of the most important phenomena for management scholars and practitioners. Yet, researchers and practitioners are often frustrated by their inability to accurately predict why individuals leave their jobs. This should be worrisome given that total replacement costs can exceed 100% of an employee’s salary (Cascio, 2006) and can represent up to 40% of a firm’s pre-tax income (Allen, 2008). Motivated by these concerns, the purpose of this study was to assess the predictive validity of commonly-investigated correlates and, by extension, conceptualizations of employee turnover using a large-scale database of scientific findings. Results indicate that job satisfaction, organizational commitment, and embeddedness (e.g., person-job fit, person-organization fit) may be the most valid proximal predictors of turnover intention. Results for a tripartite analysis of the potential empirical redundancy between job satisfaction and organizational commitment when predicting turnover intention align well with previous research on this topic and generally suggest that the two constructs may be empirically indistinguishable in the turnover context. Taken together, this study has important implications for the turnover and sensitivity analysis literatures. With regard to the sensitivity analysis literature, this study demonstrates the application of a sensitivity analysis for relative importance weights in the meta-analytic context. This new method takes into account variance around the meta-analytic mean effect size estimate when imputing relative importance weights and may be adapted to other correlation matrix-based techniques (i.e., structural equation modeling) that are often used to test theory.
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McClendon, Debra Theobald. "Relative Sensitivity to Change of Psychotherapy Outcome Measures for Children and Adolescents: A Comparison Using Parent- and Self-Report Versions of the CBCL/6-18, BASC-2, and Y-OQ-2.01." BYU ScholarsArchive, 2009. https://scholarsarchive.byu.edu/etd/2089.
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This repeated-measures study evaluated the relative sensitivity to change of the Child Behavior Checklist/6-18 (CBCL/6-18), the Behavior Assessment System for Children-2 (BASC-2), and the Youth Outcome Questionnaire-2.01 (Y-OQ-2.01). Participants were recruited from Valley Mental Health, a community outpatient clinic in Salt Lake City, UT. There were 178 participants for 136 cases, with 134 adults and 44 adolescents. Participants provided two through five data points for a total of 548 data points. Hierarchical Linear Modeling (HLM) was conducted for three major comparisons: adult informants, adult and adolescent dyads, and adolescents. Results indicated the Y-OQ-2.01 was the most change sensitive, while the BASC-2 and CBCL/6-18 were not statistically different from each other. Results also showed that the parent-report measures were more change-sensitive than the self-report measures completed by adolescent informants. Sensitivity to change was also evaluated through the reliable change index (RCI) and the use of cut-off scores. In comparisons using the RCI, the Y-OQ-2.01 identified the most cases for reliable change. The Y-OQ-2.01 also had the greatest corroboration of its findings with the other two measures. In comparisons using cut-off scores, results are offered for three variations, as different standards were used to establish cut-off scores for the three measures. The third variation, for which cut-off scores for all three measures were adjusted to one standard deviation above the mean, is suggested to be the most appropriate when comparing measures. Those results indicated there was no statistical difference in how the measures performed relative to each other. Thus, based on the HLM and RCI results of this study, it is recommended that clinicians select the Y-OQ-2.01 for outcome use and tracking changes in child and adolescent symptoms and behaviors.
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Kindermann, Dirk. "Perspective in context : relative truth, knowledge, and the first person." Thesis, University of St Andrews, 2012. http://hdl.handle.net/10023/3164.
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This dissertation is about the nature of perspectival thoughts and the context-sensitivity of the language used to express them. It focuses on two kinds of perspectival thoughts: ‘subjective' evaluative thoughts about matters of personal taste, such as 'Beetroot is delicious' or 'Skydiving is fun', and first-personal or de se thoughts about oneself, such as 'I am hungry' or 'I have been fooled.' The dissertation defends of a novel form of relativism about truth - the idea that the truth of some (but not all) perspectival thought and talk is relative to the perspective of an evaluating subject or group. In Part I, I argue that the realm of ‘subjective' evaluative thought and talk whose truth is perspective-relative includes attributions of knowledge of the form 'S knows that p.' Following a brief introduction (chapter 1), chapter 2 presents a new, error-theoretic objection against relativism about knowledge attributions. The case for relativism regarding knowledge attributions rests on the claim that relativism is the only view that explains all of the empirical data from speakers' use of the word "know" without recourse to an error theory. In chapter 2, I show that the relativist can only account for sceptical paradoxes and ordinary epistemic closure puzzles if she attributes a problematic form of semantic blindness to speakers. However, in 3 I show that all major competitor theories - forms of invariantism and contextualism - are subject to equally serious error-theoretic objections. This raises the following fundamental question for empirical theorising about the meaning of natural language expressions: If error attributions are ubiquitous, by which criteria do we evaluate and compare the force of error-theoretic objections and the plausibility of error attributions? I provide a number of criteria and argue that they give us reason to think that relativism's error attributions are more plausible than those of its competitors. In Part II, I develop a novel unified account of the content and communication of perspectival thoughts. Many relativists regarding ‘subjective' thoughts and Lewisians about de se thoughts endorse a view of belief as self-location. In chapter 4, I argue that the self-location view of belief is in conflict with the received picture of linguistic communication, which understands communication as the transmission of information from speaker's head to hearer's head. I argue that understanding mental content and speech act content in terms of sequenced worlds allows a reconciliation of these views. On the view I advocate, content is modelled as a set of sequenced worlds - possible worlds ‘centred' on a group of individuals inhabiting the world at some time. Intuitively, a sequenced world is a way a group of people may be. I develop a Stalnakerian model of communication based on sequenced worlds content, and I provide a suitable semantics for personal pronouns and predicates of personal taste. In chapter 5, I show that one of the advantages of this model is its compatibility with both nonindexical contextualism and truth relativism about taste. I argue in chapters 5 and 6 that the empirical data from eavesdropping, retraction, and disagreement cases supports a relativist completion of the model, and I show in detail how to account for these phenomena on the sequenced worlds view.
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MANCA, MAURIZIO. "Consumption and saving specification: a new perspective." Doctoral thesis, Università Politecnica delle Marche, 2014. http://hdl.handle.net/11566/242765.
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La grande maggioranza della letteratura accademica su consumo e
risparmio utilizza lo strumento di massimizzazione dell'utilità vincolata per
determinare la scelta ottimale di risparmio, funzione di utilità che dipende
dal consumo di un singolo bene omogeneo e rappresentativo dell'intero
paniere domandato dal consumatore.
Dall'osservazione di un dataset di famiglie italiane, osservate tra il 1991 ed
il 2010, si evince che il consumo in funzione del rapporto di buffer-stock,
ossia il rapporto tra ricchezza e consumo corrente, si discosta in maniera
significativa da quanto implicato dalla teoria economica tradizionale: se i
dati vengono opportunamente normalizzati per la numerosità del nucleo
familiare e per il livello soglia di povertà, il consumo presenta bensì
asimmetrie in reazione a shock di liquidità di segno opposto e non linearità
tali da sollevare qualche dubbio sulla portata informativa del costrutto
teorico.
Tali presunte irregolarità possono essere conciliate se si arricchisce il set
informativo su cui poggiano le decisioni di consumo e risparmio e si
suddivide l'intervallo di valori del rapporto buffer-stock in tre opportune
categorie di consumatori. Una simile specificazione delle scelte di
consumo e risparmio viene discussa e implementata in un modello di
simulazione computazionale ad agenti eterogenei.<br>The vast majority of the academic literature on consumption and saving,
expecially for the last 40 years, describes the household consumption
function as the outcome of a constrained maximization of of the utility
coming from the consumption of a single homogenous good, for the latter
can be seen as representing the bundle of goods desired by the households
in her steady state.
I observed in a dataset of italian households that consumption function
exhibits asymmetric shocks and non linearities that can be comprehended
by splitting the households' buffer-stock ratio distribution into three
intervals. In this paper I discuss a stochastic model capable of managing
such heterogeneity by an agent based computer simulation.
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Patton, Roy Lee. "Studies on the use of foliar peroxidase activity as a predictor of relative sensitivity to ozone among selected groups of populus hybrids and other trees /." The Ohio State University, 1985. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487259580263383.
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Soares, Maria João de Sousa. "An avian relative fatality risk index for Iberian species on wind farms based on zero inflated count models." Master's thesis, Universidade de Aveiro, 2014. http://hdl.handle.net/10773/13866.
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Mestrado em Biologia Aplicada<br>Climate change is one of the greatest threats towards humankind and wildlife. This consciousness motivated the search for alternatives that could contribute to mitigate climate change. Betting on renewable energies seems to be a winning strategy adopted worldwide in order to reduce greenhouse gas emissions responsible for global climate alterations and to improve nations’ energy independency. However, nowadays, these energy usages still have negative impacts, mostly on wildlife. Wind energy is even considered the greatest unintended human impact on avifauna. In this context, the aim of this thesis was to increase the knowledge about wind farms impacts on avifauna, which variables influence birds’ fatalities by collision with wind turbines and birds’ vulnerability. Models based on excessive zero counts were tested to understand which variables influence birds’ fatalities assessed on 25 Portuguese wind farms. This allowed to estimate the probability of mortality observation per species. The information obtained was used to build the fatality risk index that also considered the vulnerability factors, which give information of species conservation concern and resilience. Those indexes allow to prioritise the existing and limited conservation efforts on more vulnerable species. Models and indexes are also important for improving knowledge about wind energy impacts on wildlife and what can lead to reduce them, in order to achieve a sustainable and greener future.<br>As alterações climáticas são uma das maiores ameaças para a Humanidade e para a vida selvagem. A consciência sobre a importância destas questões motivou a procura de alternativas, com intuito de mitigar estas alterações globais, causadas nomeadamente pelos gases de efeitos de estufa. Assim, as energias renováveis apresentam-se como uma possível estratégia vencedora a adotar, de forma a reduzir as emissões destes gases e levar à independência energética. No entanto, o uso destas energias renováveis ainda apresenta impactes negativos, especialmente para os ecossistemas. A energia eólica é inclusivamente considerada uma das maiores causas não intencionais de origem antropogénica para a mortalidade adicional de aves. Neste contexto, esta dissertação tem como os principais objetivos o desenvolvimento do conhecimento relativo aos impactes da energia eólica, quais as variáveis que influenciam a mortalidade de aves respeitante à colisão com as turbinas eólicas assim como as variáveis que afetam a vulnerabilidade das espécies. Foram testados modelos de contagem com excesso de zeros para compreender a influência das variáveis nas observações de mortalidade em 25 parques eólicos portugueses. A partir destes modelos foi possível estimar a probabilidade de observação de mortalidade para cada uma das espécies estudadas, provocada por colisão com eólicas. Esta informação foi ainda utilizada de forma a desenvolver um índice de risco de fatalidade com base nestas estimativas, assim como em fatores elucidativos da vulnerabilidade das espécies, nomeadamente o seu estatuto de conservação e resiliência. Desta forma é então possível direcionar esforços e recursos para a preservação das espécies com maior vulnerabilidade e prioridade de conservação. Este tipo de modelos e índices é ainda fundamental para incrementar o conhecimento sobre os impactes da energia eólica na vida selvagem e para compreender quais as medidas que podem ser tomadas para os reduzir e, assim, garantir um futuro mais verde e sustentável para todas as formas de vida.
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Raimundo, António Ângelo Viegas Fialho. "Avaliação financeira do Grupo Jerónimo Martins." Master's thesis, Universidade de Évora, 2021. http://hdl.handle.net/10174/31067.
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O objetivo deste trabalho de investigação consiste em determinar o valor da empresa Jerónimo Martins e o preço de cotação das suas ações.
Os métodos de avaliação utilizados foram os seguintes: método dos cash flows descontados (fluxo de caixa livre para a empresa, para os acionistas, ótica dos dividendos) e o método de avaliação relativa. Em relação ao método de avaliação relativa, recorreu-se ao PER (Price to Earnings Ratio), PBV (Price to Book Value) e PS (Price to Sales).
Para além disso, foi realizada uma análise de sensibilidade, com o intuito de determinar o efeito das variações das variáveis chave no preço final por ação e avaliar a robustez dos resultados.
Por conseguinte, estimou-se que o valor da Jerónimo Martins é igual a 20.110.445 milhares de euros, através do método do fluxo de caixa livre para a empresa, com um Price Target de 31,12€, recomendando-se a compra de ações; Equity Research of Jerónimo Martins
Abstract:
The main goal of this study is to determine the Jerónimo Martins’ firm value and, therefore, the value of its shares.
The valuation methods used were the following: discounted cash flow method (free cash flow to the firm, free cash flow to equity, dividend perspective) and the relative valuation (market multiples method). Regarding the relative valuation method, the PER (Price to Earnings Ratio), the PBV (Price to Book Value) and the PS (Price to Sales) were used.
In addition, a sensitivity analysis was made, in order to determine the effect of changes in key variables on the final share price and measure the robustness of the results.
Therefore, it was estimated that Jerónimo Martins’ firm value is equal to 20.110.445 thousand euros, using the free cash flow to the firm, with a Price Target of 31,12€, recommending the purchase of JM shares by investors.
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McClendon, Debra Theobald. "Relative sensitivity to change of psychotherapy outcome measures for children and adolescents: a comparison using parent - and self -report version of the CBLC/6, BASC-2, and Y-OQ-2.01 /." Diss., CLICK HERE for online access, 2009. http://contentdm.lib.byu.edu/ETD/image/etd2914.pdf.
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Samadi, Afshin. "Large Scale Solar Power Integration in Distribution Grids : PV Modelling, Voltage Support and Aggregation Studies." Doctoral thesis, KTH, Elektriska energisystem, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-154602.
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Long term supporting schemes for photovoltaic (PV) system installation have led to accommodating large numbers of PV systems within load pockets in distribution grids. High penetrations of PV systems can cause new technical challenges, such as voltage rise due to reverse power flow during light load and high PV generation conditions. Therefore, new strategies are required to address the associated challenges. Moreover, due to these changes in distribution grids, a different response behavior of the distribution grid on the transmission side can be expected. Hence, a new equivalent model of distribution grids with high penetration of PV systems is needed to be addressed for future power system studies. The thesis contributions lie in three parts. The first part of the thesis copes with the PV modelling. A non-proprietary PV model of a three-phase, single stage PV system is developed in PSCAD/EMTDC and PowerFactory. Three different reactive power regulation strategies are incorporated into the models and their behavior are investigated in both simulation platforms using a distribution system with PV systems. In the second part of the thesis, the voltage rise problem is remedied by use of reactive power. On the other hand, considering large numbers of PV systems in grids, unnecessary reactive power consumption by PV systems first increases total line losses, and second it may also jeopardize the stability of the network in the case of contingencies in conventional power plants, which supply reactive power. Thus, this thesis investigates and develops the novel schemes to reduce reactive power flows while still keeping voltage within designated limits via three different approaches: decentralized voltage control to the pre-defined set-points developing a coordinated active power dependent (APD) voltage regulation Q(P)using local signals developing a multi-objective coordinated droop-based voltage (DBV) regulation Q(V) using local signals In the third part of the thesis, furthermore, a gray-box load modeling is used to develop a new static equivalent model of a complex distribution grid with large numbers of PV systems embedded with voltage support schemes. In the proposed model, variations of voltage at the connection point simulate variations of the model’s active and reactive power. This model can simply be integrated intoload-flow programs and replace the complex distribution grid, while still keepingthe overall accuracy high. The thesis results, in conclusion, demonstrate: i) using rms-based simulations in PowerFactory can provide us with quite similar results using the time domain instantaneous values in PSCAD platform; ii) decentralized voltage control to specific set-points through the PV systems in the distribution grid is fundamentally impossible dueto the high level voltage control interaction and directionality among the PV systems; iii) the proposed APD method can regulate the voltage under the steady-state voltagelimit and consume less total reactive power in contrast to the standard characteristicCosφ(P)proposed by German Grid Codes; iv) the proposed optimized DBV method can directly address voltage and successfully regulate it to the upper steady-state voltage limit by causing minimum reactive power consumption as well as line losses; v) it is beneficial to address PV systems as a separate entity in the equivalencing of distribution grids with high density of PV systems.<br><p>The Doctoral Degrees issued upon completion of the programme are issued by Comillas Pontifical University, Delft University of Technology and KTH Royal Institute of Technology. The invested degrees are official in Spain, the Netherlands and Sweden, respectively. QC 20141028</p>
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Miranda, L. N. de. "Aluminium-phosphate interactions in relation to wheat growth." Thesis, University of Reading, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.355697.
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Draaijer, Petronella. "Macro- and microcirculatory derangements in borderline hypertension relation to salt-sensitivity /." Maastricht : Maastricht : Universitaire Pers Maastricht ; University Library, Maastricht University [Host], 1994. http://arno.unimaas.nl/show.cgi?fid=7911.
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Yacoub, Jocelyne. "Odor detection sensitivity and response bias in relation to aspects of health." Thesis, Umeå universitet, Institutionen för psykologi, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-118014.
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Chemical intolerance (CI) means that the affected individual experience symptoms from the smell of the weak concentrations of conventional chemicals in the environment that most people are not bothered by. This study aimed to examine whether response bias (beta) and sensitivity index (d´) for odor detection correlate with self-rated health, CI, stress and distress. The questionnaires that were used to answer the question were self-rated health (SRH), CI (assessed with the Chemical Sensitivity Scale), stress (Perceived Stress Scale) and distress (Symptom Check List-90). A group of 23 adult individuals between the ages of 18 to 55 years expected to vary in degree of CI were exposed to various concentration of n-butanol for a signal detection test for about 2 hours. The data processing was done by correlational analyses. The results showed no statistically significant correlations between beta and the variables SRH, CI, stress and distress, but tendencies of significant correlations between d´ and the variables SRH, CI and stress, such that individuals who were high in CI, stress and who generally felt poorly had a lower odor sensitivity (d´). These tendencies encourage continued study of the associations with larger sample size.<br>Kemisk intolerans (KI) innebär att den drabbade individen upplever symtom från lukten av svaga koncentrationer av konventionella kemikalier i miljön som de flesta människor inte besväras av. Denna studie syftade till att undersöka om respons-bias (beta) och känslighetsindex (d´) för luktdetektion korrelerar med självskattad hälsa, KI, stress och allmän hälsa. De frågeformulär som användes för att svara på frågan var självskattad hälsa (SRH), KI (bedömd med Chemical Sensitivity Scale), stress (Perceived Stress Scale) och allmän mental hälsa (Symptom Check List-90). En grupp av 23 vuxna individer i åldrarna 18 till 55 år som förväntades variera i grad av KI exponderades för olika koncentrationer av n-butanol för ett signaldetektionstest under 2 timmar. Dataprocessen gjordes med korrelationsanalyser. Resultatet visade ingen statistisk signifikant korrelation mellan beta och variablerna SRH, KI, stress och allmän hälsa, men tendenser av signifikanta korrelationer mellan d´ och variablerna SRH, KI och stress, på så sätt att individer som var höga i KI, stress och som allmänt kände sig mentalt dåliga hade en lägre luktkänslighet (d´). Dessa tendenser uppmuntrar till fortsatta studier av association med större stickprovstorlek.
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Saulnier, Kevin G. "Perfectionism and Anxiety Sensitivity: The Relation between Etiological Factors of Social Anxiety." Ohio University / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1544448461375123.
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Henriksson, Marie-Louise, and Johan Troedsson. "Samspel mellan föräldrar och deras 16-månaders barn : Kommunikativ utveckling i relation till mind-mindedness och föräldrasensitivitet." Thesis, Linköpings universitet, Logopedi, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-94000.
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Hur föräldrar samspelar med barn kan ha stor påverkan på barnets språkliga och kommunikativa utveckling. Föräldrasensitivitet och mind-mindedness är två mått som mäter föräldrars samspel. Föräldrasensitivitet mäter förälderns förmåga att uppfatta och tolka barnets signaler och mind-mindedness innefattar förälderns användande av ord som handlar om barnets mentala processer. Dessa mentaliseringsyttranden kan vara intonade eller icke-intonade utifrån situationen och barnets sinnesstämning. I vilken grad föräldrars mind-mindedness och föräldrasensitivitet påverkar olika delar av den kommunikativa utvecklingen är till stora delar fortfarande okänt. Syftet med föreliggande studie var att undersöka om föräldrasensitivitet och föräldrars mind-mindedness korrelerar med kommunikativa förmågor, om mind-mindedness och föräldrasensitivitet korrelerar med varandra samt om några könsskillnader förelåg. Materialet bestod av 35 inspelade förälder-barndyader som observerats när barnen var ca 16 månader. För att mäta föräldrasensitivitet användes lyhördhetsskalan ”Lyhördhet eller icke-lyhördhet för barnets signaler”. För att mäta mind-mindedness kodades förälder-barndyaderna samt föräldrabeskrivningar utifrån manualen för mind-mindedness av Meins och Fernyhough (2010). De kommunikativa förmågorna mättes dels genom the Swedish Early Communicative Development Inventories och dels genom the Early Social Communication Scales. Resultatet visade att det förelåg samband mellan föräldrasensitivitet och kommunikativa förmågor. Såväl språkförståelse, kommunikativa gester samt delad uppmärksamhet korrelerade med föräldrasensitivitet. Beträffande föräldrars mind-mindedness, konstaterades ett samband mellan en hög andel icke-intonade mentaliseringsyttranden och bristande förmåga till delad uppmärksamhet. Vidare framkom samband mellan mind-mindedness och föräldrasensitivitet: en förälder med hög föräldrasensitivitet använde fler intonade mentaliseringsyttranden än en förälder med låg föräldrasensitivitet. Ett motsvarande omvänt samband uppstod mellan icke-intonade mentaliseringsyttranden och en låg nivå av föräldrasensitivitet, där en icke-lyhörd förälder använde fler icke-intonade mentaliseringsyttranden. Slutligen upptäcktes en könsskillnad som innebar att föräldrar använder fler icke-intonade mentaliseringsyttranden till pojkar än till flickor.<br>The way a parent interacts with his or her child can have a great effect on communication and language development of the child. Maternal sensitivity and mind-mindedness are two measures used for parent-child interplay. Maternal sensitivity measures the parent’s ability to accurately perceive and interpret the child’s cues while mind-mindedness involves the parent’s use of words and comments regarding the child’s internal state. These comments can be classified as appropriate or non-attuned regarding the situation and the child’s state of mind. To what extent mind-mindedness and maternal sensitivity affect different parts of the child’s communicative development is still mainly unknown. The purpose of the present study was to investigate if maternal sensitivity and mind-mindedness co-vary with communicative abilities, if mind-mindedness and maternal sensitivity co-vary with each other, and finally, if any gender differences was present. The material of the study consisted of 35 videotaped parent-child interactions, which were observed when the children were 16 months of age. To measure maternal sensitivity, the sensitivity scale were used, “Sensitivity vs. Insensitivity to the Baby's Signals”. To measure mind-mindedness, parent-child interplay and parental interviews were coded. The child’s communicative abilities were assessed with the Swedish Early Communicative Development Inventories and with the Early Social Communication Scales. The result showed a correlation between maternal sensitivity and language comprehension, communicative gestures and joint attention. A relationship was found between mind-mindedness and parents’ using more non-attuned mental comments and children’s decreasing ability to respond to joint attention. The results also demonstrated that a sensitive parent uses more appropriate mental comments than a parent who was insensitive. A reversed relationship was found between non-attuned mental comments and a low level of maternal sensitivity, where the insensitive parent used more non-attuned mental comments. Finally, a difference in gender was found, where parents use more non-attuned comments to boys than to girls.<br>FAS dnr 2008-0875
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Henderson, Melanie. "Lifestyle habits and their relation to insulin sensitivity and insulin secretion in youth." Thesis, McGill University, 2014. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=121130.
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Background: Decreased insulin sensitivity and impaired pancreatic B-cell function have been identified as key components in the pathogenesis of type 2 diabetes mellitus. Understanding how to best measure insulin dynamics in epidemiologic studies in youth, and determining how lifestyle habits influence these measures are essential to the development of preventive strategies for at risk youth. Objectives: 1) To identify the best measures of insulin sensitivity and insulin secretion that can be used in large epidemiologic studies in children 2) To determine how physical activity, fitness, sedentary behavior, and macronutrient intake are associated with these measures of insulin sensitivity and insulin secretion in children 3) To determine if lifestyle habits predict insulin sensitivity over a 2 year period in childrenMethods: For the first objective, 20 healthy children with normal glucose metabolism (9 boys and 11 girls, mean (SD) age: 9(2) years) were studied. Each child underwent a 3-hour hyperinsulinemic-euglycemic clamp study (gold standard for measuring insulin sensitivity), an insulin modified minimal model FSIVGTT, and a 3-hour oral glucose tolerance test (OGTT). Various measures of both insulin sensitivity and insulin secretion were calculated, and correlations against the reference method were established using Spearman's rank correlations. For objectives 2 and 3, data were drawn from the baseline and first follow-up assessments of the QUALITY cohort, which includes 630 Caucasian youth (aged 8-10 years at recruitment) with at least one obese biological parent. Measures of insulin sensitivity and secretion were derived from fasting data and OGTT data. Fitness was measured by VO2 peak; percent fat mass (PFM) was measured by DXA; 7-day moderate-to-vigorous physical activity was measured using accelerometry. Screen time was determined by the average daily hours of self-reported television, video game or computer use. Multivariable linear regression models were adjusted for age, sex, season and puberty. Non-parametric smoothing splines were used to model non-linear associations between lifestyle habits and measures of insulin sensitivity or secretion. Results: Several measures of insulin sensitivity and insulin secretion derived from the OGTT, as well as from fasting-based data, performed well against the reference methods. Physical activity and screen time were associated with insulin sensitivity both cross-sectionally and longitudinally. This association was largely mediated by adiposity. Fitness was independently associated with insulin sensitivity. Finally, dietary composition was not associated with insulin sensitivity or secretion in children.Conclusions:The OGTT allows the estimation of insulin sensitivity and insulin secretion in youth and is the method that most closely mimics normal physiology. Lifestyle habits play an important role in insulin dynamics in youth, with adiposity however showing the greatest influence.<br>Contexte: Une diminution de la sensibilité à l'insuline et de la fonction des cellules bêta pancréatiques ont été identifiées comme les éléments centraux de la pathogénèse du diabète de type 2. Comprendre comment mieux mesurer la sensibilité et la sécrétion de l'insuline dans les études épidémiologiques chez les jeunes, et déterminer comment les habitudes de vie influencent ces mesures dans cette population est essentiel au développement de stratégies préventives efficaces pour les enfants à risque. Objectifs: 1)Identifier les meilleures mesures de la sensibilité à l'insuline et de la sécrétion d'insuline pouvant être utilisées dans de grandes études épidémiologiques chez l'enfant 2) Déterminer comment l'activité physique, la condition physique, la sédentarité et la composition alimentaire sont associées à ces mesures de sensibilité et de sécrétion d'insuline chez l'enfant 3) Déterminer si les habitudes de vie prédisent la sensibilité à l'insuline sur une période de suivi de 2 ans chez les enfants Méthodes: Les participants à l'étude de l'objectif 1 sont vingt enfants (9 garçons et 11 filles), âgés en moyenne de 9 ans (écart-type = 2), tous normo-tolérants au glucose. Un clamp hyperinsulinémique-euglycémique (étalon d'or pour la mesure de la sensibilité à l'insuline), une hyperglycémie provoquée par voie intra-veineuse modifiée à l'insuline et une hyperglycémie orale provoquée (HGOP), chacun d'une durée de 3 heures, ont été réalisés. Plusieurs mesures de sensibilité à l'insuline et de sécrétion d'insuline ont été calculées et corrélées contre l'étalon d'or utilisant le test de corrélation de Spearman. Pour les objectifs 2 et 3, les données utilisées proviennent de l'évaluation initiale et du premier suivi de la cohorte QUALITY, qui comprend 630 enfants caucasiens (âgés de 8-10 ans au recrutement) avec au moins un parent biologique obèse. Les mesures de sensibilité à l'insuline et de sécrétion d'insuline ont été dérivées des échantillons à jeun et de l'HGOP. La condition physique a été mesurée par le VO2 de pointe; le pourcentage de masse grasse a été mesuré par DXA; l'activité physique modérée à vigroureuse a été mesurée sur 7 jours avec un accéléromètre. Le temps d'écran a été déterminé par le temps moyen quotidien rapporté de télévision, jeux vidéo et d'ordinateur. Des modèles de régression linéaire ont été corrigés pour l'âge, le sex, la saison et le stade de puberté. Des fonctions splines à lissage non-paramétriques ont été utilisées pour modéliser les associations non-linéaires entre les habitudes de vie et la sensibilité ou la sécrétion d'insuline. Résultats: Nous avons identifié des mesures de sensibilité à l'insuline et de sécrétion d'insuline dérivées de l'HGOP, ainsi que des indices à jeun, qui performaient bien contre la méthode de référence. Par ailleurs, l'activité physique et le temps d'écran étaient associés avec la sensibilité à l'insuline de façon transversale et longitudinale, mais cette association était largement médiée par l'adiposité. La condition physique était indépendamment associée à une meilleure sensibilité à l'insuline de façon transversale. Enfin, la composition alimentaire ne semblait pas indépendamment associée à une meilleure sensibilité à l'insuline ou sécrétion d'insuline chez l'enfant. Conclusions: L'HGOP offre la possibilité d'estimer la sensibilité à l'insuline et la sécrétion d'insuline chez l'enfant et demeure la méthode qui reproduit le mieux la physiologie normale. Les habitudes de vie chez l'enfant jouent un rôle important dans la sensibilité/sécrétion d'insuline, l'adiposité démontrant toutefois la plus grande influence.
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Bravo, Irene Maria. "Assessment of anxiety sensitivity in depressed, older patients and its relation to hypochondriacal concerns." FIU Digital Commons, 1998. http://digitalcommons.fiu.edu/etd/1804.
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Anxiety disorders in older adults are often overlooked as part of other mental disorders or as part of medical illnesses. Theoretically, anxiety sensitivity is a common component in anxiety disorders, a personality construct and a fundamental fear. Anxiety sensitivity was assessed in a sample of older adults: 53 depressed, M age = 78.8 years; and 53 healthy controls, M age = 70.9 years. This study examined whether anxiety sensitivity: (1) explained unique variance beyond that explained by trait anxiety, (2) was observed in the depressed group in levels similar to individuals who suffer from non-panic, anxiety disorders, and (3) correlated with current number of medical illnesses, previous number of medical illnesses, and hypochondriasis. The results indicated that anxiety sensitivity: predicted hypochondriasis better than trait anxiety, was present in the depressed group similarly to individuals suffering from non-panic, anxiety disorders, and was strongly associated with hypochondriacal concerns.
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Buthsaraporn, Surakhaka Polrat Wilairatana. "Therapeutic response of falciparum malaria in relation to in vitro sensitivity of plasmodium falciparum /." Abstract, 2000. http://mulinet3.li.mahidol.ac.th/thesis/2543/43E-Buthsaraporn-S.pdf.
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Cross, Andrew. "An investigation of carbon flows from forest soils, in relation to climatic warming." Thesis, University of Edinburgh, 2009. http://hdl.handle.net/1842/3805.
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Rises in anthropogenic CO2 emissions are now widely acknowledged to be responsible for changes in the global climate, with potentially disastrous consequences if these rises continue unchecked. Although knowledge of ecosystem responses to climate change has improved, there are still large underlying uncertainties regarding their response to warming. Of all the ecosystems with the potential to mitigate rises in CO2, forests are arguably the most important because of their huge land area and store of carbon. A large proportion of the carbon stored in forests is found in the soil, and it is the response of this soil carbon to temperature that is the main determinant of a forest’s ability to act as a carbon sink, or indeed source. Understanding the response of soil carbon flux to temperature, as well as the contribution of soil carbon flux to the carbon balance of forests as a whole is crucial in helping to improve modelling approaches. In this thesis I first examined the temperature response of old and new soil organic carbon from a Sitka spruce plantation under controlled laboratory conditions. Both the old and new soil organic carbon showed similar temperature sensitivities after prolonged incubation at 20 °C, thus implying a similar response to increasing temperatures. Using a variety of different methods (root intensity, meshing and stable isotope analysis) I then studied the responses under field conditions. These methods showed that autotrophic respiration was responsible for up to 50 % of total soil respiration, and was more sensitive to temperature than heterotrophic respiration. Finally, I compared the contributions and determinants (particularly temperature and moisture) of soil respiration fluxes to ecosystem fluxes at a temperate (Sitka spruce) and Mediterranean (Maritime pine) forest. Temperature was found to be the dominant driver of soil respiration fluxes at the temperature forest, whilst soil respiration was limited by moisture at the Mediterranean forest. Statistically significant relationships between net ecosystem productivity and soil respiration (and the stable isotope signature of soil respiration) were found at both forests, indicating a close coupling between above-ground processes and soil respiration.
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Robertson, L. "Callous-unemotional traits and rejection-sensitivity in relation to subtypes of aggression in adolescent offenders." Thesis, University College London (University of London), 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.625407.
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Volume One of this D.Clin.Psy thesis is a research project investigating rejection-sensitivity and callous-unemotional traits in relation to subtypes of aggression and offending in adolescent offenders. The study was designed to advance the current findings in the area. The volume is divided into three parts. Part One is a literature review examining whether it is possible to apply the construct of psychopathy to youth. Part Two is an empirical paper which outlines the literature relating to aggression and offending in young people, including an exploration of factors thought to underlie these behaviours, including rejection-sensitivity and callous-unemotional traits. The study explored the hypotheses that rejection-sensitivity and callous-unemotional traits would differentially predict subtypes of aggression and offending behaviour. The results are discussed in relation to previous findings. The paper closes with a discussion of the study in terms of limitations, the clinical implications and directions for future research. Part three is a critical appraisal of the research process. It outlines how the area of study came to be selected and includes reflections on the wider research process. The clinical implications arising from the study are discussed in more detail. Some consideration is given throughout to the narratives that society holds about young people who offend and how these narratives might influence our ideas about how best to intervene.
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Spira, Adam P. "The relation of anxiety sensitivity and coping strategy to carbon dioxide-induced anxious and fearful responding." Morgantown, W. Va. : [West Virginia University Libraries], 2001. http://etd.wvu.edu/templates/showETD.cfm?recnum=1993.
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Nichols-Lopez, Kristin A. "Anxiety Sensitivity’s Facets in Relation to Anxious and Depressive Symptoms in Youth." FIU Digital Commons, 2010. http://digitalcommons.fiu.edu/etd/268.
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Anxiety sensitivity is a multifaceted cognitive risk factor currently being examined in relation to anxiety and depression. The paucity of research on the relative contribution of the facets of anxiety sensitivity to anxiety and depression, coupled with variations in existing findings, indicate that the relations remain inadequately understood. In the present study, the relations between the facets of anxiety sensitivity, anxiety, and depression were examined in 730 Hispanic-Latino and European-American youth referred to an anxiety specialty clinic. Youth completed the Childhood Anxiety Sensitivity Index, the Revised Children’s Manifest Anxiety Scale, and the Children’s Depression Inventory. The factor structure of the Childhood Anxiety Sensitivity Index was examined using ordered-categorical confirmatory factor analytic techniques. Goodness-of-fit criteria indicated that a two-factor model fit the data best. The identified facets of anxiety sensitivity included Physical/Mental Concerns and Social Concerns. Support was also found for cross-ethnic equivalence of the two-factor model across Hispanic-Latino and European-American youth. Structural equation modeling was used to examine models involving anxiety sensitivity, anxiety, and depression. Results indicated that an overall measure of anxiety sensitivity was positively associated with both anxiety and depression, while the facets of anxiety sensitivity showed differential relations to anxiety and depression symptoms. Both facets of anxiety sensitivity were related to overall anxiety and its symptom dimensions, with the exception being that Social Concerns was not related to physiological anxiety symptoms. Physical/Mental Concerns were strongly associated with overall depression and with all depression symptom dimensions. Social Concerns was not significantly associated with depression or its symptom dimensions. These findings highlight that anxiety sensitivity’s relations to youth psychiatric symptoms are complex. Results suggest that focusing on anxiety sensitivity’s facets is important to fully understand its role in psychopathology. Clinicians may want to target all facets of anxiety sensitivity when treating anxious youth. However, in the context of depression, it might be sufficient for clinicians to target Physical/Mental Incapacitation Concerns.
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Mekhail-Ishak, Kamilia. "Biochemical components of xenobiotic metabolism in human colon and in murine breast : relation to drug sensitivity." Thesis, McGill University, 1989. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=74268.
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The biochemical characterization of phase I and phase II components considered to be important in the metabolism of carcinogens and other xenobiotics was examined in two experimental models. This was done to elucidate the relationship between the process of carcinogenesis and the selection of a biochemical phenotype which could result in drug resistance, previously described in rat hepatocarcinogenesis models.<br>A model of mammary carcinogenesis in mice demonstrated no significant biochemical change relating to potential drug resistance among normal, preneoplastic and neoplastic mammary tissues. This is of particular interest since human breast cancer is usually quite drug sensitive at the start of the treatment.<br>Human colon cancer is probably induced by carcinogenic compounds present in the environmental dietary elements and also exhibits de novo resistance to most antineoplastic drugs. Most of the biochemical elements examined were found to be present in these colon tissues. Additionally, the detoxification pathways including glutathione and its related enzymes, were found to be significantly elevated in colon tumor versus normal adjacent mucosa. The molecular characterization of glutathione S-transferase (GST) isoenzymes using antibodies and cloned molecular probes to specific enzyme forms showed that the anionic form of GST (GST-$ pi)$ is greater in tumors than in the respective normal mucosa. The neutral form (GST-$ mu)$ is conversely decreased in tumor relative to normal. The cationic (GST-$ alpha)$ is present only in 30% of the samples examined, with no difference between tumor and adjacent normal mucosa. The expression of cytochrome P-450 isoenzymes was also examined in a similar fashion; a phenobarbital-inducible form was expressed in most colon tissues examined, and expression of the polycyclic aromatic hydrocarbons-inducible P$ sb3$-450 was present in some colon tissues while mRNA for P$ sb1$-450 was not detected in any. The biochemical alterations found in human colon could be the targets of therapeutic manoeuvers to enhance the efficacy of antineoplastic treatment of human colon cancer.
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Tarczynski-Bowles, M. L. "Assessment of a new speech rhythm sensitivity measure and its relation with children's reading skill development." Thesis, Coventry University, 2013. http://curve.coventry.ac.uk/open/items/e3f9e39c-5251-44ed-8eef-48af248a3e41/1.
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This thesis evaluated a new speech rhythm measure, the Lexical Judgement Task (LJT), by conducting a series of cross-sectional studies. It was examined whether the LJT could be used with children from different age groups, whether associations between speech rhythm sensitivity, phonological awareness and reading skills could be observed and whether speech rhythm sensitivity could predict reading skills cross-sectionally and longitudinally. Study 1 piloted the LJT with 5- to 9-year-old children and assessed the relationship between poor and good readers‟ speech rhythm sensitivity and their reading skills. Analyses showed that poor readers performed lower on the task compared to good readers, indicating that reduced stress sensitivity was related to lower reading proficiency. Examination of the task indicated potential fatigue effects, thus the task was shortened, which resulted in a 12-item tasks that was used through the remainder of the studies. Children between 4- and 11-years old were assessed in three following studies and results showed differential associations between stress sensitivity and reading (related) skills; indicating an involvement of maturation in stress sensitivity‟s development but also highlighting that stress sensitivity is involved in reading skills differently across varying ages. The final study in this thesis examined the longitudinal effect of stress sensitivity on reading skills and it was found that stress sensitivity was not able to account for growth in reading skills, independently from vocabulary or phonological processing skills; although concurrently unique variance in reading skills was accountable to stress sensitivity. Overall, this thesis highlights the importance of stress sensitivity in children‟s reading development, offers supporting evidence for previously found associations between this skills and reading abilities and demonstrates the need to incorporate speech rhythm sensitivity in theoretical reading development models.
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Hagström, Emil. "Metabolic Disturbances in Relation to Serum Calcium and Primary Hyperparathyroidism." Doctoral thesis, Uppsala University, Department of Surgical Sciences, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-6893.
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<p>Primary hyperparathyroidism (pHPT), characterized by elevated serum levels of calcium and parathyroid hormone (PTH), is associated with a number of metabolic derangements causing secondary manifestations. These include osteoporosis and increased risk of fractures, but also risk factors for cardiovascular morbidity and mortality. These risk factors include impaired glucose tolerance (IGT), dyslipidemia, increased body mass index and hypertension. While the skeletal abnormalities are mainly due to elevated PTH, the latter disturbances are still unexplained. Non-insulin dependent diabetes mellitus (NIDDM), IGT, dyslipidemia and hypertension are all included in the metabolic syndrome, also associated with morbidity and mortality in cardiovascular diseases.</p><p>In this thesis, decreased bone mineral density (BMD) and variables of the metabolic syndrome are explored in patients with mild and normocalcemic pHPT before and after parathyroidectomy. To further investigate the relationship between insulin sensitivity and calcium, a community-based cohort was investigated.</p><p>In two different patient cohorts of pHPT, lipoprotein alterations with decreased levels of HDL-cholesterol and elevated triglycerides were found in association with a high frequency of IGT, NIDDM and decreased insulin sensitivity. Parathyroidectomy had effects on the dyslipidemia and in part on the glucose metabolism. The disturbed glucose metabolism in pHPT was substantiated by results from the general population by a negative association between insulin sensitivity, measured by hyperinsulinemic clamp, and serum calcium.</p><p>In conclusion, normocalcemic, mild and overt pHPT are associated with a range of risk factors for cardiovascular diseases, development of NIDDM and decreased BMD in cortical as well as trabecular bone. These findings explain, at least in part, the elevated morbidity and mortality from cardiovascular disease as well as fractures, reported in pHPT patients. Moreover, in the general population, serum calcium is associated with decreased insulin sensitivity. Parathyroidectomy has positive effects on several, but not all, of the investigated metabolic parameters.</p>
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Hiavacova, Alexandra. "Enhanced adrenergic sensitivity of mesenteric veins comparied to arteries and its relation to calcium utilization and handling." Diss., Connect to online resource - MSU authorized users, 2008.
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Thesis (Ph.D.)--Michigan State University. Dept. of Pharmacology and Toxicology, 2008.<br>Title from PDF t.p. (viewed on July 10, 2009) Includes bibliographical references (p. 226-256). Also issued in print.
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Scarinci, Teresa. "Sensitivity Relations and Regularity of Solutions of HJB Equations arising in Optimal Control." Thesis, Paris 6, 2015. http://www.theses.fr/2015PA066573.
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Dans cette thèse nous étudions une classe d’équations de Hamilton-Jacobi-Bellman provenant de la théorie du contrôle optimal des équations différentielles ordinaires. Nous nous intéressons principalement à l’analyse de la sensibilité de la fonction valeur des problèmes de contrôle optimal associés à de telles équations de H-J-B. Dans la littérature, les relations de sensibilité fournissent une “mesure” de la robustesse des stratégies optimales par rapport aux variations de la variable d’état. Ces résultats sont des outils très importants pour le contrôle appliqué, parce qu’ils permettent d’étudier les effets que des approximations des données du système peuvent avoir sur les politiques optimales. Cette thèse est dédiée également à l’étude des problèmes de Mayer et de temps minimal. Nous supposons que la dynamique du problème soit une inclusion différentielle, afin de permettre aux données d’être non régulières et d’embrasser un ensemble plus grand d’applications. Néanmoins, cette tâche rend notre analyse plus difficile. La première contribution de cette étude est une extension de quelques résultats classiques de la théorie de la sensibilité au domaine des problèmes non paramétrées. Ces relations prennent la forme d’inclusions d’état adjoint, figurant dans le principe du maximum de Pontryagin, dans certains gradients généralisés de la fonction valeur évalués le long des trajectoires optimales. En deuxième lieu, nous développons des nouvelles relations de sensibilité impliquant des approximations du deuxième ordre de la fonction valeur. Cette analyse mène à de nouvelles applications concernant la propagation, tant ponctuel que local, de la régularité de la fonction valeur le long des trajectoires optimales. Nous proposons également des applications aux conditions d’optimalité<br>This dissertation investigates a class of Hamilton-Jacobi-Bellman equations arising in optimal control of O.D.E.. We mainly focus on the sensitivity analysis of the optimal value function associated with the underlying control problems. In the literature, sensitivity relations provide a measure of the robustness of optimal control strategies with respect to variations of the state variable. This is a central tool in applied control, since it allows to study the effects that approximations of the inputs of the system may produce on the optimal policies. In this thesis, we deal whit problems in the Mayer or in the minimum time form. We assume that the dynamic is described by a differential inclusion, in order to allow data to be nonsmooth and to embrace a large area of concrete applications. Nevertheless, this task makes our analysis more challenging. Our main contribution is twofold. We first extend some classical results on sensitivity analysis to the field of nonparameterized problems. These relations take the form of inclusions of the co-state, featuring in the Pontryagin maximum principle, into suitable gradients of the value function evaluated along optimal trajectories. Furthermore, we develop new second-order sensitivity relations involving suitable second order approximations of the optimal value function. Besides being of intrinsic interest, this analysis leads to new consequences regarding the propagation of both pointwise and local regularity of the optimal value functions along optimal trajectories. As applications, we also provide refined necessary optimality conditions for some class of differential inclusions
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Von, Hase Amrei. "Why do flowers in Namaqualand close? : Flower closure in relation to the environment and pollen sensitivity to moisture." Bachelor's thesis, University of Cape Town, 1998. http://hdl.handle.net/11427/25985.
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Namaqualand, South Africa, is a desert system characterised by predictable winter rainfall and mild temperatures. Flowering coincides with the wet season which imposes constraints on pollination success. The wide-spread phenomenon of flower closure in the flora may represent an adaptation for protecting sensitive pollen from damage by moisture (dew, rain). The literature dealing with the subject is sparse and we addressed this gap by investigating patterns of flower closure in relation with environmental variables (potential cues). We also determined the effect of water on pollen in field and laboratory situations. The findings are that air temperature closely reflects moisture levels and is the cue for diurnal patterns in flower closure. Of the abiotic factors tested, it best explains the biological variable of flower temperature which is closely correlated with flower closure. Variation among species in their response to ambient temperature is demonstrated by individual thresholds for flower opening and differing strengths of the relationship. The detrimental effect of moisture on pollen viability emerges in four species (Mesembryanthemaceae, Asteraceae) where exposure to water caused significant pollen damage. Field experiments on two of these species confirm significant damage under natural conditions. Petal closure is the dominant protective mechanism in these plants and effectively prevents losses in reproductive potential caused by moisture. This has evolutionary significance as many Namaqualand species persist via annual recruitment. In two species (Asteraceae) that do not close their petals above inflorescences, pollen viability was retained despite placement in water. They may have a different protective strategy, such as a germination inhibitor, or their pollen could be insensitive to water.
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Matthews, Abigail. "Interpersonal sensitivity in bulimia and depression an examination of the relation between social feedback, self-perceptions, and mood /." Diss., Online access via UMI:, 2009.
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Reilly, N. L. "Empathy and rejection sensitivity in relation to reactive, proactive and relational aggression in 10- to 12-year-old children." Thesis, University College London (University of London), 2007. http://discovery.ucl.ac.uk/1445026/.
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The hypothesis that empathy inhibits aggression and therefore that a deficit in empathy may underlie aggressive behaviour (Feshbach, 1978) was investigated in this review. Twenty empirical papers examining the association between empathy and aggression in children and adolescents were reviewed. The studies revealed inconsistent results, particularly in relation to children. Amongst the studies of adolescent samples, there tended to emerge a significant negative association between empathy and aggression. More recent studies, and studies employing measures of situational empathy, yielded the most consistent evidence for a negative association between empathy and aggression. Gender differences were rarely reported, but one recent study offered some tentative support for the notion of a differential association between empathy and certain forms of aggression in girls compared with boys. Clinical implications and directions for future research are discussed in light of the results of this review.
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Gaillard, Trudy R. "Effects of aerobic vs. resistive exercise on glucose transporter proteins and insulin sensitivity in obese nondiabetic female first-degree relatives of African American patients with type 2 diabetes." The Ohio State University, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=osu1110317859.
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Johansson, Björn. "A Study of Some Temporal Properties of the Human Visual Evoked Potential, and Their Relation to Binocular Function." Doctoral thesis, Linköpings universitet, Oftalmologi, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-7584.
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As disturbed binocular functions in small children may lead to severe amblyopia it is of interest to detect it as early as possible. Most tests for binocular functions, however, demand active cooperation and may be unreliable in children up to 4-5 years of age. This study therefore aims to employ visual evoked potentials (VEP) to enable the examiner to evaluate the binocular function in a subject without need of active cooperation from the subject. Initially we studied the relation of suprathreshold contrast to the latency of the transient pattern VEP (tpVEP). Although suprathreshold contrast independently influenced the tpVEP latency, interindividual variation was too large to suggest tpVEP as a possible method for objectively measuring contrast sensitivity in a subject. The tpVEP latency in normal and microstrabismic adult subjects was examined. It was significantly shorter with binocular viewing in normals, but not in the microstrabismic group. Contrast sensitivity and tpVEP latency was examined in adults, both with normal binocularity and with microstrabismus, using both luminance (black-and-white) contrast and colour contrast patterns. The tpVEP latency to colour contrast, like that to luminance contrast, is shorter in normal subjects who view the stimulus binocularly. Interindividual variation or overlap between the normal and microstrabismic groups did not improve with colour contrast. The most significant features of the tpVEP are amplitude and latency. Depending on stimulus conditions, the response may show variations in configuration, amplitude and, to a lesser degree, latency. To decrease the influence of such variations steady-state VEP (ssVEP) can be used. The stimulus is presented in a fast repetitive manner, yielding a VEP response shaped as a continuous curve. The frequency components of this curve can be analysed using Fast Fourier Analysis. Fast Fourier analysis of ssVEP in children aged 8-15 years with normal binocularity and with microstrabismus showed that the power of the second harmonic (the double frequency of stimulus frequency) of the response with binocular viewing was larger than with monocular viewing, both in normals and microstrabismic subjects. For higher stimulus frequencies, microstrabismic subjects showed a significantly lower power of the second harmonic compared with subjects with normal binocularity, when the stimulus was presented binocularly. Finally, Fast Fourier analysed ssVEP in pre-school children aged 4-5 years was studied. A normal group was compared with a group with microstrabismus and a group with significant amblyopia. Amblyopic subjects had significant interocular differences in the first harmonic. We confirmed the significant difference found between microstrabismic subjects and subjects with normal binocularity regarding the second harmonic’s power with higher temporal frequency binocular stimulation, although at a slightly lower frequency than for older children. A low power of the second harmonic in the ssVEP to a binocular stimulus with high temporal frequency is a strong indicator of disturbed binocular function.<br>För att förhindra amblyopi (ensidig synsvaghet) hos barn är det viktigt att upptäcka störningar i samsynsfunktionerna så tidigt som möjligt. Samsynstester kräver dock aktiv medverkan och kan ge osäkra resultat hos barn upp till 4-5 års ålder. Den här avhandlingen studerar möjligheterna att utifrån tidsmässiga (temporala) egenskaper hos visual evoked potentials (VEP) undersöka samsynsfunktioner objektivt, utan att den undersökte behöver medverka aktivt. Första delstudien visar att ett synstimulus kontrastnivå i relation till kontrastkänslighetströskeln oberoende påverkar latensen i VEP, men variationer mellan individer gör metoden olämplig som objektiv kontrastkänslighetstest. Andra delstudien jämför latensen i VEP hos individer med normal samsyn med den hos personer med mikroskelning. Stimulering av båda ögonen gav signifikant kortare latens än stimulering av ett öga hos normala, men inte hos mikroskelare. I den tredje delstudien jämfördes känslighet för luminanskontrast och färgkontrast hos individer med normal samsyn och personer med mikroskelning. Både luminansmönster (svart-vita) och färgkontrastmönster upptäcktes vid lägre kontrast om båda ögonen stimulerades istället för ett i taget hos normalseende. Mikroskelare uppfattade mönstren sämre med båda ögonen än med ett öga (det dominanta). Latensen i VEP mättes i båda grupperna för både luminans- och färgkontrastmönster. Båda typerna av kontrast gav förkortning av latensen när båda ögonen stimulerades vid normal samsyn, men denna förkortning uteblev hos mikroskelare. Både luminans- och färgkontrast gav för varierande resultat för att utnyttja metoden för objektiv undersökning av samsynen. Fourier-analys innebär att en kurvform delas upp i sinuskurvor med olika frekvens, amplitud och fas. Om ett stimulus växlar hastigt får man ett steady-state VEP (ssVEP), dvs en kontinuerligt vågformad VEP-kurva, som kan delas upp i delsinuskurvor med Fourieranalys. Detta gör att man särskilt kan studera frekvenser som är relaterade till stimuleringsfrekvensen, till exempel grundton och övertoner (multipler av grundtonsfrekvensen). Barn 8-15 år gamla, med normal samsyn och med mikroskelning undersöktes med ssVEP i det fjärde delarbetet. Den första övertonen (= ”second harmonic”) var statistiskt signifikant svagare hos mikroskelare jämfört med normala individer, när stimuleringsfrekvensen var hög. Det femte och sista delarbetet undersökte ssVEP hos 4-5 år gamla förskolebarn på motsvarande sätt. I denna studie deltog också en grupp barn med amblyopi (synsvaghet) på ena ögat. På en något lägre stimuleringsfrekvens bekräftades den svagare första övertonen hos barnen med mikroskelning jämfört med barnen med normal samsyn. De amblyopa barnen visade tydligast förändringar vid lägre stimuleringsfrekvenser och i ssVEP:s grundtonsfrekvens (= ”first harmonic” eller ”fundamental harmonic”). Resultaten i de olika grupperna är så pass åtskilda att metoden verkar lämpa sig för objektiv undersökning av samsynsfunktioner, i det att en svag första överton i binokulärt ssVEP utlöst av hög stimuleringsfrekvens inger en stark misstanke om störd samsyn, medan en stor skillnad i grundtonens styrka i höger respektive vänster ögas ssVEP tyder på amblyopi.
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Johansson, Björn. "A study of some temporal properties of the human visual evoked potential, and their relation to binocular function /." Linköping : Linköping University, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-7584.
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Mao, Yuping. "Does Culture Matter? Relating Intercultural Communication Sensitivity to Conflict Management Styles, Technology Use, and Organizational Communication Satisfaction in Multinationals in China." Ohio University / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1281741620.
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Velander, Ida. "Personlighetsdrag som prediktorer för högkänslighet : En enkätundersökning avseende högkänslighet i relation till personlighetsdragen enligt femfaktormodellen." Thesis, Karlstads universitet, Institutionen för sociala och psykologiska studier, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-55216.
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The aim of the present study was to investigate how sensory processing sensitivity is related to the personality traits extraversion, agreeableness, emotional stability, conscientiousness and autonomy of the five-factor model. The samples for the study were members of the Association for the Highly Sensitive in Sweden and a Facebook community for highly sensitive individuals. The participants in the present study responded on a web-based questionnaire to participate. To answer the purpose of the study The Highly Sensitive Person scale (HSPS) were used to measure the degree of a person’s sensitivity. The Five Factor Personality Inventory (FFPI) was used to measure the Big Five personality traits. The data were analyzed in the statistics program SPSS with Pearson’s correlations coefficient and a multiple regression analysis. The result of the multiple regression analysis showed that personality traits of neuroticism and agreeableness predicted sensory processing sensitivity. Further on results showed that the personality traits of extraversion, conscientiousness and autonomy not predicted sensory processing sensitivity. The results of the study conclude that participants of the study are much likely to have the personality traits neuroticism and introversion. Furthermore, results indicated that the participants of the study had the personality traits agreeableness, conscientiousness and autonomy. Continued studies with other methodological starting points are needed to achieve greater knowledge about the personality trait sensory processing sensitivity.<br>Studiens syfte var att undersöka om det fanns en relation mellan högkänslighet och personlighetsdragen extraversion, vänlighet, samvetsgrannhet, öppenhet samt emotionell stabilitet enligt femfaktormodellen. Urvalet bestod av medlemmar från Sveriges Förening för Högkänsliga och en Facebookgrupp som riktar sig till högkänsliga personer. För att besvara frågeställningen användes en webbaserad enkät som mailades ut till medlemmarna i Sveriges Förening för Högkänsliga samt publicerades i Facebookgruppen. Beroendevariabeln högkänslighet mättes med mätinstrumentet The Highly Sensitive Person Scale (HSPS). Oberoendevariablerna extraversion, vänlighet, samvetsgrannhet, emotionell stabilitet och öppenhet mättes med mätinstrumentet The Five Factor Personality Inventory (FFPI). Dataanalyserna som genomfördes i studien var Pearsons korrelationskoefficient och multipel regressionsanalys. Regressionsanalysen visade att personlighetsdragen emotionell stabilitet och vänlighet var prediktorer för högkänslighet. Personlighetsdragen extraversion, samvetsgrannhet och öppenhet var inte prediktorer för högkänslighet. Resultatet indikerade att studiens deltagare i högre grad hade personlighetsdragen neuroticism och introversion. Vidare visade resultatet att studiens deltagare hade grad av personlighetsdragen samvetsgrannhet, vänlighet och öppenhet. Studien gav en indikation på hur hög grad av högkänslighet var i relation till andra personlighetsdrag. Resultatet kan således öka kunskapen om högkänslighet och vad det medför. Fortsatta studier med andra metodologiska utgångspunkter krävs för att få ökad kunskap om personlighetsdraget högkänslighet.
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Gustafsson, Stefan. "Electromagnetic dispersion modeling and analysis for HVDC power cables." Licentiate thesis, Linnéuniversitetet, Institutionen för datavetenskap, fysik och matematik, DFM, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-32525.
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Derivation of an electromagnetic model, regarding the wave propagation in a very long (10 km or more) High Voltage Direct Current (HVDC) power cable, is the central part of this thesis. With an existing “perfect” electromagnetic model there are potentially a wide range of applications.The electromagnetic model is focused on frequencies between 0 and 100 kHz since higher frequencies essentially will be attenuated. An exact dispersion relation is formulated and the propagation constant is computed numerically. The dominating mode is the first Transversal Magnetic (TM) mode of order zero, denoted TM01, which is also referred to as the quasi-TEM mode. A comparison is made with the second propagating TM mode of order zero denoted TM02. The electromagnetic model is verified against real time data from Time Domain Reflection (TDR) measurements on a HVDC power cable. A mismatch calibration procedure is performed due to matching difficulties between the TDR measurement equipment and the power cable regarding the single-mode transmission line model.An example of power cable length measurements is addressed, which reveals that with a “perfect” model the length of an 80 km long power cable could be estimated to an accuracy of a few centimeters. With the present model the accuracy can be estimated to approximately 100 m.In order to understand the low-frequency wave propagation characteristics, an exact asymptotic analysis is performed. It is shown that the behavior of the propagation constant is governed by a square root of the complex frequency in the lowfrequency domain. This thesis also focuses on an analysis regarding the sensitivity of the propagation constant with respect to some of the electric parameters in the model. Variables of interest when performing the parameter sensitivity study are the real relative permittivityand the conductivity.
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Nasralla, Eman Abdulwahhab. "Metabolic syndrome and relation of obesity indices to biomarkers of insulin sensitivity and inflammation among Qatari men and women : the Qatar Biobank Project." Thesis, Imperial College London, 2015. http://hdl.handle.net/10044/1/34919.
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Background: Increased body fatness along with other conditions typical of the metabolic syndrome (MetS) such as insulin resistance have become more prevalent in Qatar due to rapid transitions in the Qatari's population lifestyle in the last few decades. The government of Qatar is seeking to improve the public's health; however, epidemiological studies on Qataris are limited. Aims: This research aims to 1) describe the features of the MetS and its determinants among a sample of Qataris, 2) explore the difference between four obesity subgroups regarding selected factors of metabolic health and 3) investigate the association of total and central body fatness indices with C-peptide and glycated haemoglobin A1c (HbA1c) as insulin sensitivity biomarkers and with fibrinogen as a biomarker of inflammation. Methods: This is a cross-sectional study of 879 Qatari men and women from the Qatar Biobank pilot phase. The MetS prevalence was estimated using the National Cholesterol Education Programme Adult Panel III (NCEP ATPIII), International Diabetes Federation (IDF) and the harmonised criteria. Metabolic health status for the four obesity subgroups (metabolically-healthy normal weight, metabolically-abnormal normal weight, metabolically-healthy obese and metabolically-abnormal obese) was identified using the harmonised guidelines. Multiple linear regression analyses were conducted to test the relation of the obesity indices (including body mass index, body fat percentage, waist circumference (WC) and waist-hip ratio) to C-peptide, HbA1c and fibrinogen. Results: The prevalence of the MetS was 18.4% (NCEP ATPIII), 27.0% (IDF), and 28.9% (harmonised definition). Central obesity was the most prevalent determinant of the MetS. There were significant differences in multiple factors of metabolic health for each of the four obesity subgroups. There were strong positive associations between the examined obesity indices and C-peptide, HbA1c and fibrinogen. WC had the strongest positive association with C-peptide, HbA1c and fibrinogen compared to the other examined body fatness indices. Conclusions: The current findings suggest that future interventions should target reducing WC in Qataris. The four obesity subgroups differed significantly regarding multiple factors of metabolic health; this implies that they might need to be treated differently. More epidemiological studies are needed to aid the Qatari government in their decision making to improve the public's health.
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BETTONI, MANUELE. "What makes a soil landscape robust? Assessment of landscape sensitivity in relation to land use changes in a southern Alpine valley (Ticino, Switzerland)." Doctoral thesis, Università degli studi di Pavia, 2023. https://hdl.handle.net/11571/1469884.
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Balboni, Tania <1989>. "Mammary carcinoma and angiogenesis: study of the role of HER2 in relation to tumor angiogenesis process and to the sensitivity to anti-tumoral drugs." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2018. http://amsdottorato.unibo.it/8367/1/Thesis_TaniaBalboni_no%20report.pdf.
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Despite the correlation between HER2 expression and tumor angiogenesis, anti-angiogenesis drugs failed to reach sufficient efficacy in patients to be approved for HER2-positive breast cancer.
About half of HER2-positive breast cancer presents an alternative splicing isoform called Δ16.
Tumors developed on mouse models transgenic for one or both isoforms of HER2 have different aspects, and angiogenesis seems to occur in different ways. In this way, HER2 and Δ16 seem to drive different angiogenic phenotypes.
Therefore, the aim of this thesis was to better analyze the role of the two isoforms in determining different patterns of vascularization. The different vascularization has been put in relation to the different effects of anti-angiogenic and anti-HER2 drugs. This study has been performed through histological, functional and molecular analysis of the tumors.
The analysis of the vascularization in F1 tumors, in which one isoform or both can be expressed, revealed that the presence of HER2 is crucial for the establishment of the FVBhuHER2-like phenotype.
The dominant role of full-length HER2 in tumor angiogenesis has been confirmed in a dynamic in vivo model of modulation of the expression of this isoform.
HER2 isoforms have been found to have a crucial role in tumor angiogenesis. The dominant behavior of full-length HER2 affects the regularity of the vascular pattern, determining a vasculature that is less permeable to drugs and therefore less sensitive to anti-angiogenic and targeted agents. A molecular profile with more genes involved in sprouting angiogenesis suggests the need to further study the role of full-length HER2 in tumor vascularization, to find new targets to improve the pharmacological response to therapies.
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Gaillard, Trudy. "Effects of aerobic vs. resistive exercise on glucose transporter proteins and insulin sensitivity in obese nondiabetic female first-degree relatives of African American patients with type 2 diabetes." Connect to this title online, 2005. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1110317859.
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Thesis (Ph. D.)--Ohio State University, 2005.<br>Title from first page of PDF file. Document formatted into pages; contains xvii, 172 p.; also includes graphics Includes bibliographical references (p. 127-138). Available online via OhioLINK's ETD Center
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Mauffré, Christian-Eric. "Influence de la qualité de la relation visiteur médical–médecin généraliste sur l’intention de prescrire un nouveau médicament." Thesis, Grenoble, 2013. http://www.theses.fr/2013GRENG012.
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La qualité de la relation établie entre le visiteur médical et le médecin prescripteur influence la fidélité du médecin prescripteur envers le visiteur médical et son intention de prescrire un nouveau produit. Le choix de faire référence exclusivement au contenu de la relation par le concept de la relation, est une démarche originale dans le champ de la prescription, il est validé par les résultats de l’enquête. Si pour prescrire le médecin généraliste n’a pas besoin d’éléments autres que son expérience personnelle de ce médicament, l’influence de la fidélité envers le visiteur médical aura une faible importance. A l’inverse, pour une nouveauté médicamenteuse le médecin basera son intention de prescrire sur la qualité de la relation mise en place, mais également sur sa fidélité envers le visiteur médical, représentant d’un laboratoire. En isolant la variable sensibilité à l’innovation du médecin généraliste, nous pouvons démontrer son influence sur l’intention de prescrire un nouveau médicament. Or l’innovation est un enjeu majeur pour l’industrie pharmaceutique mais également pour le médecin, elle concerne à la fois la connaissance et la prescription des médicaments. L’information est complexe par la multiplicité des sources et le médecin devra appuyer sa décision de prescrire un nouveau médicament sur une caractéristique individuelle, sa propre sensibilité à l’innovation. Nos résultats montrent qu’en 2013 en France il est difficile d’élaborer des stratégies de lancement de médicament, en ignorant l’orientation relationnelle des médecins. Nos résultats mettent en évidence l’influence de la qualité de la relation sur l’intention de prescrire. Notre approche permettra, non seulement de mieux comprendre les mécanismes de création et de développement de la qualité de la relation entre le visiteur médical et le médecin généraliste, mais également de mesurer ce concept par l’intermédiaire de ses composants (confiance, satisfaction et engagement dans la relation). De même, la sensibilité à l’innovation est une caractéristique individuelle du médecin généraliste, que les responsables marketing lors des stratégies de ciblage des médecins, doivent prendre en compte avant un lancement<br>The quality of the relationship between the pharmaceutical sales representative and the physician, influence the prescribing physician loyalty to the pharmaceutical sales representative, the relationship quality also influences the physician to prescribe a new product. The decision to refer exclusively to the contents of the relationship with the concept of the relationship, is a novel approach in the field of prescription, it is validated by the results of the investigation. If the general practitioner, to prescribe, does not need items other than his personal experience of this drug, the influence of loyalty to the health visitor will have little importance. Conversely, for a new drug the doctor will base its intention to prescribe on the quality of the established relationship, but also on his loyalty to the pharmaceutical representative, Isolating the variable sensitivity to innovation, of the general practitioner, we can demonstrate its influence on his intention to prescribe a new drug. But innovation is a major challenge for the pharmaceutical industry and also for the physician; it involves both knowledge and prescription of drugs. The information appears complex due to the multiplicity of sources and the doctor will base its decision to prescribe a new drug on personal characteristic, its own vision of the novelty, his own sensitivity to innovation. Our results show that in 2013 in France it is difficult to develop strategies to launch drug while ignoring the relational orientation of physicians. Our results highlight the influence of the quality of the relationship on the intention to prescribe. Our approach will not only allow a better understanding of the mechanisms of creation and development of the quality of the relationship between the pharmaceutical sales representative and the general practitioner, but also to measure this concept through its components (trust, satisfaction and commitment in the relationship). Similarly, sensitivity to innovation is an individual characteristic of the general practitioner, as marketers in targeting strategies physicians should consider before launch. Similarly, sensitivity to innovation is an individual characteristic of the general practitioner, as such; it must be taken in account when marketers are targeting strategies to them