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1

Ibrahimov, F., G. Abdullayeva, and S. Amrahova. "INTERPRETATION OF THE CONCEPT OF "INDEPENDENT WORK OF A STUDENT IN A GENERAL EDUCATION SCHOOL" BASED ON THE CONCEPT OF "SUBSYSTEM OF EDUCATIONAL ACTIVITY"." Scientific heritage, no. 161 (May 27, 2025): 30–34. https://doi.org/10.5281/zenodo.15524032.

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The article emphasizes that the need to form an educational space in line with the challenges of the Fourth Industrial Revolution makes it urgent to rework the theoretical and technological directions related to its implementation. Although the discovery of the nature of the training system, which is understood as a way of implementing the aforementioned education, and the discovery of new approaches require theoretical and technological research, the theoretical and technological aspects of organizing independent work in the training process in accordance with the modern educational environme
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2

Kostova, Bilyana, Daniela Paneva, Zara Cherkezova-Zheleva, Katerina Mihaylova, and Boyan Dumanov. "Ancient Metallurgical Iron Slags—Chemical, Powder X-ray Diffraction and Mössbauer Spectroscopic Study." Crystals 13, no. 6 (2023): 888. http://dx.doi.org/10.3390/cryst13060888.

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The production and trade of metals was the foundation of the economic wealth of many regions in the world, which makes the study of ancient metallurgical slags of primary importance. This type of study is relatively new for Bulgaria, where research in the field started in the late 1960s with chemical analysis of copper ore, slags, tools and finished goods from the ancient copper mine in the Ay-bunar area. Iron is one of the most commonly found elements in the earth’s crust and its deposits are widespread, including on Bulgaria’s territory. To this day, however, the study of iron slags from Bul
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Hidayat, Rachmad, Hidayat, Rifky Maulana Yusron, Wasiur, and Moh Jufriyanto. "The Influence of Oil Raw Materials on The Quality of Finished Soap Products in The Laboratory Division at PT. Solar Wings Corps." E3S Web of Conferences 328 (2021): 05009. http://dx.doi.org/10.1051/e3sconf/202132805009.

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The business actors are required to generate the maximum profit possible, thus demanding workers to work productively. This cannot be denied because workers are the most essential element in running the company’s wheels. PT Wings Surya is a manufacturing company that produce soap. this research activity focuses on how to check soap products using the AOCS Method, in which the AOCS (The American Oil Chemists’ Society) method is a method applied to measure and analyze levels in oil so that it is known whether these levels already meet the standards to be processed into a quality product. The qua
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Hunar, Marek, Lukas Jancar, David Krzikalla, David Kaprinay, and David Srnicek. "Comprehensive View on Racing Car Upright Design and Manufacturing." Symmetry 12, no. 6 (2020): 1020. http://dx.doi.org/10.3390/sym12061020.

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This paper deals with the design of an upright using a topological optimization. This type of optimization is a relatively young and rapidly evolving area of computational mechanics that seeks to make multiple material savings that cannot be achieved by conventional methods. The optimized upright was utilized in a fully functional prototype of the student formula within the Formula Student competition. The main objective of the optimization was to meet the requirements of the physical properties, weight, stiffness, and strength of the upright. The initial model of the upright was iteratively o
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Merouani, Amar. "The second revolution of relativity." JOURNAL OF ADVANCES IN PHYSICS 20 (February 8, 2022): 30–35. http://dx.doi.org/10.24297/jap.v20i.9179.

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Energy, this vital entity that we need, and that everyone consumes and liberates, in different forms, has been since the dawn of time the greatest concern of the human being. Over the centuries, energy has transformed lifestyles in all societies of the world, contributing to the emergence of new cities and major cosmopolitan cities. Scientific research has contributed to much of this extraordinary advance of energy in the conquest of the world, thanks to the many works and discoveries of scientists from the golden age of Islamic civilization to the renaissance in Europe, to the great technolog
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Noor Mardliyah. "Team Game Tournament Learning Model to Improve the Students’ Speaking Achievement." IJOLTL-TL (Indonesian Journal of Language Teaching and Linguistics) 5, no. 3 (2020): 199–214. http://dx.doi.org/10.30957/ijoltl.v5i3.637.

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This study aims to find out whether the implementation of TGT can improve students’ speaking ability and activity in grade IX-D of MTs Negeri 2 Kudus. This is a classroom action research. This research was carried out in several cycles. Each cycle consists of planning, implementing, observing, and reflecting. The variables of this study comprise of student achievement and teacher activity. The results showed the teacher's performance increased according to the criteria on the indicator, which was shown in cycle I was sufficient and cycle II to be good. Student activities during learning are ve
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7

PÁLFI, György. "Komoly kihívás a szegedi antropológia számára: a mohácsi terepantropológiai projekt." Anthropologiai Közlemények, no. 62 (December 22, 2021): 103–17. http://dx.doi.org/10.20330/anthropkozl.2021.62.103.

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The 500th anniversary of the tragic 1526 Mohács battle is quickly approaching. The Duna-Dráva National Park, the manager of the Memorial Park of Mohács, has initiated a series of research and development to commemorate the battle anniversary, among others the excavation of some of the Memorial Park’s mass graves, the individual identification of the mixed human remains, the scientific examination of the skeletons and the individuals’ reburial with belated respect. In 2020, the year our Szeged Department celebrated the 80th birthday of its foundation, the Szeged anthropology team was asked to c
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8

de Groot, R. P., P. J. Rijken, J. den Hertog, et al. "Microgravity decreases c-fos induction and serum response element activity." Journal of Cell Science 97, no. 1 (1990): 33–38. http://dx.doi.org/10.1242/jcs.97.1.33.

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Several studies have shown that altered gravity conditions influence mammalian cell growth and differentiation. The molecular mechanisms underlying these effects, however, remain relatively obscure. In this paper we show that microgravity reached in a sounding rocket strongly decreases epidermal growth factor (EGF)-induced expression of the proto-oncogenes c-fos and c-jun, which are both implicated in the regulation of proliferation and differentiation. Decreased activity of the serum response element (SRE), present in the c-fos promoter-enhancer region, is probably responsible for the decreas
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9

Artem, Ushchapovskyi, and Ivchuk Nadiya. "USE OF SEMI-FINISHED CHERRY-BEET PUREE IN TECHNOLOGY OF SWEET DISHES AND DESSERTS." TECHNOLOGY AUDIT AND PRODUCTION RESERVES 3, no. 1(53) (2020): 42–44. https://doi.org/10.15587/2706-5448.2020.205176.

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<em>Sweet dishes and desserts are in high demand among consumers. However, these products usually have an unbalanced chemical composition, high caloric content, high fat and carbohydrate content, relatively low protein content and insufficient amount of biologically active substances. The source of natural biologically active substances (BAS) are purees, juices, extracts, decoctions of fruits, vegetables, cultivated and wild berries, medicinal herbs and more. Therefore, the current issue for this type of product is to improve the recipe of the existing range of sweet dishes through the use of
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10

Karelauw, Martina, Ayu Septiany Korsely, Grasela Devana Tahya, Melvati Faumasa, Agusthinus Matulessy, and Verrel Gabriel Liklikwatil. "ANALISIS SISTEM INFORMASI AKUNTANSI SIKLUS PRODUKSI PADA USAHA LIMA JAYA." Jurnal Tagalaya Pengabdian Kepada Masyarakat 1, no. 2 (2024): 131–36. https://doi.org/10.71315/jtpkm.v1i2.20.

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Accounting information systems play an important role in managing financial and operational information in a company’s production cycle. This community service aims to analyze the accounting information system used by LIMA JAYA Enterprises in managing their production cycle. The activity method used is a case study by collecting primary data through interviews with company management and direct observation of the ongoing production process. The results of this activity indicate that the accounting information system used by LIMA JAYA businesses in their production cycle is quite integrated and
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11

Wei, Wei. "Structure Optimization for Hydraulic Press Based on Approximate Model." Applied Mechanics and Materials 442 (October 2013): 287–90. http://dx.doi.org/10.4028/www.scientific.net/amm.442.287.

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A method of structure optimization for hydraulic press is proposed in order to reduce mass while assuring adequate stiffness. Upper beam and lower beam are determined as optimal objects by mass analysis. Key geometric parameters of upper beam and lower beam which have relatively larger impacts on mass and stiffness are extracted as design variables. In order to research relationship between stiffness, mass and design variables, command batch file is built by python language to implement automatic finite element analysis in ABAQUS. Orthogonal experimental design is used to generate samples of d
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12

Wu, Yuxiao, Peini Shi, Qingsong Yang, and Na Zhang. "Effect of Packaging Method and Storage Environment on Activity of Magnesium Oxide and Mechanical Properties of Basic Magnesium Sulfate Cement." Materials 17, no. 15 (2024): 3628. http://dx.doi.org/10.3390/ma17153628.

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As one of the raw materials of basic magnesium sulfate cement (BMSC), the activity of light-burned magnesium oxide (MgO) has an important effect on the hydration rate, hydration products, and mechanical properties of BMSC. To reveal the influence of packaging method, storage environment, and storage time on the activity of MgO and the mechanical properties of BMSC, an experiment was conducted by using ordinary woven bags, peritoneal woven bags, and plastic and paper compound bags to store the finished BMSC and the raw materials (light-burned MgO, MgSO4·7H2O, fly ash, and a chemical additive) u
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13

Pierce, Richard A., Carla H. Moore, and Meltem Cevik Arikan. "Positive transcriptional regulatory element located within exon 1 of elastin gene." American Journal of Physiology-Lung Cellular and Molecular Physiology 291, no. 3 (2006): L391—L399. http://dx.doi.org/10.1152/ajplung.00441.2004.

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Elastin gene transcription is cell type specific and developmentally regulated, but the promoter often exhibits relatively weak activity in transient transfections of cells that express elastin at high levels. To search for positive-acting regulatory sequences, we isolated genomic clones spanning the mouse elastin gene and extensive 5′- and 3′-flanking regions. Restriction fragments of potential regulatory regions were ligated 5′ or 3′ relative to the active promoter to test for enhancer activity in transient transfections of fetal rat lung fibroblasts, which express elastin at high levels, an
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14

Hasnat, Mohammad Tanvirul, Md Taslim, and Md Mahabub Hasan. "Testing potentiality of copper particles as antimicrobial agent by kirby bauer test to inhibit the activity of various microorganisms when applied to fabrics especially medical wear." International Journal of Agriculture and Animal Production, no. 51 (June 25, 2025): 59–70. https://doi.org/10.55529/ijaap.51.59.70.

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Traditional antimicrobial finishes often rely on synthetic chemicals, which is costly alongside not suitable for the environment. Commercially available antimicrobial agents, when applied to textiles, often result in the release of hazardous effluents during laundering processes. These effluents pose significant environmental threats and, in extreme cases, may have detrimental effects on human health, particularly among vulnerable populations such as infants. In light of these concerns, the current study purpose is to find out an easiest way to find out antimicrobial using copper sulphate a co
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15

Putri, Desmahan Anugrah, Hurriyaturrohman Hurriyaturrohman, and N. A. Rumiasih. "Analysis of the Application Activity-Based Costing Cost of Production Bens Qurban." inovator 13, no. 2 (2024): 149–59. https://doi.org/10.32832/inovator.v13i2.438.

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Cost of Production or product cost is an important element to assess the success (performance) of a trading or manufacturing company. Cost of production is related to indicators of the company's success, such as gross sales profit, net profit. The calculation of cost of productions (COP) is all production costs used to process a raw material into goods.to process a raw material into finished goods in a certain period of time. The research focused on the products BENS QURBAN Delivery, Titip Sembelih and Praktis. The research begins with an exploration of what activities will affect the occurren
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16

Xu, Tao, Ling Feng, Wen Yin, Jinpeng Wei, Yarong Wang, and Xianli Zou. "Element Geochemical Characteristics and Provenance Conditions of the 1st Member of Jurassic Zhongjiangou Formation in Wudun Sag, Dunhuang Basin." Applied Sciences 12, no. 9 (2022): 4110. http://dx.doi.org/10.3390/app12094110.

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In order to clarify the provenance of the 1st member of the Zhongjiangou formation in Wudun sag, Dunhuang basin, the structural attributes, weathering and sedimentary characteristics of the provenance area were analyzed by means of element geochemistry, so as to determine the differences of sediment sources in different well areas. The results show that the higher the Al2O3 and K2O contents, the higher the enrichment of large ion lithophile elements and high field strength elements, while the iron and magnesium elements are relatively deficient, and there are characteristics of medium degree d
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17

Ivanov, I., A. Matіukhin, A. Ben, Yu Kryvykh, and O. Kulabnieva. "DETERMINATION OF THE STRESSED METAL STATE DURING HOT ROLLING BY THE FINITE ELEMENT METHOD." New Materials and Technologies in Metallurgy and Mechanical Engineering, no. 4 (December 20, 2023): 50–55. http://dx.doi.org/10.15588/1607-6885-2023-4-7.

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Purpose. Determination of the stress-strain state of the metal during the rolling of large ingots to prevent the occurrence of internal defects, and determining the effect of forced cooling of the ingot surface during hot rolling on the stress-strain state.&#x0D; Research methods. Finite element method, upper estimate method.&#x0D; Results. Based on the finite element method, a comparative simulation of the stress-strain state of the ingot with different cooling times was performed. As a result of the study, it was established that the forced cooling of the ingot surface during hot rolling hel
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18

Andriukhin, Roman, Lavr Molchanov, and Yevhen Synehin. "PHYSICAL MODELING OF STEEL HOMOGENIZATION DURING FINISH ALLOYING IN THE MOLD." Modern Problems of Metalurgy, no. 24 (March 28, 2021): 4–11. http://dx.doi.org/10.34185/1991-7848.2021.01.01.

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The article describes the method of finish alloying steel in molds in top and bottom casting. Due to the reduction of oxygen activity in the metal due to the relatively lower casting temperature than the previous stages of steelmaking redistribution, it is achieved the reduction of the ferroalloys loss and increasing the yield of useful elements of ferroalloys. An important indicator of the implementation of the proposed technology is the alloying of steel in the mold to obtain steel of a certain brand in small volumes. The aim of the study is to determine the rational place of addition of all
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19

Gaasbeek, Esther J., Jaap A. Wagenaar, Magalie R. Guilhabert, et al. "A DNase Encoded by Integrated Element CJIE1 Inhibits Natural Transformation of Campylobacter jejuni." Journal of Bacteriology 191, no. 7 (2009): 2296–306. http://dx.doi.org/10.1128/jb.01430-08.

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ABSTRACT The species Campylobacter jejuni is considered naturally competent for DNA uptake and displays strong genetic diversity. Nevertheless, nonnaturally transformable strains and several relatively stable clonal lineages exist. In the present study, the molecular mechanism responsible for the nonnatural transformability of a subset of C. jejuni strains was investigated. Comparative genome hybridization indicated that C. jejuni Mu-like prophage integrated element 1 (CJIE1) was more abundant in nonnaturally transformable C. jejuni strains than in naturally transformable strains. Analysis of
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20

Kovalenko A. B. and Bezverkha K. S. "SOCIAL AND ETHNIC IDENTITIES MANIFESTATIONS DURING UKRAINIAN EMIGRANT’S ADAPTATION." International Journal of Innovative Technologies in Social Science, no. 4(25) (May 31, 2020): 18–26. http://dx.doi.org/10.31435/rsglobal_ijitss/31052020/7057.

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In the article is presented a result of researching the manifestations of social and ethnic identities in the process of adaptation of Ukrainian emigrants who live abroad (28 countries in general).Emigrants have a high level of social identity, and also high levels membership satisfaction, thanks to being a member of their reference group; self-understanding and self-development, grade of belonging and the favor of informal relationships. Middle levels have the scales of in-group grade and cohesion. The low index has been revealed according to the intergroup relationships scale.Social identity
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21

Catt, Diana, Shannon Hawkins, Ann Roman, Wen Luo, and David G. Skalnik. "Overexpression of CCAAT Displacement Protein Represses the Promiscuously Active Proximal gp91phox Promoter." Blood 94, no. 9 (1999): 3151–60. http://dx.doi.org/10.1182/blood.v94.9.3151.

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Abstract CCAAT displacement protein (CDP) is a transcriptional repressor that restricts expression of the gp91phox gene to mature myeloid cells. CDP interacts with multiple sites within the −450 to +12 bp human gp91phox promoter, and down-regulation of CDP DNA-binding activity is required for induction of gp91phox transcription in mature phagocytes. Truncation of the gp91phox promoter to −102 to +12 bp removes 4 CDP-binding sites and reveals a promiscuous promoter activity that is active in some nonphagocytic cells. A cis-element at −90 bp is required for derepressed transcription and serves a
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22

Catt, Diana, Shannon Hawkins, Ann Roman, Wen Luo, and David G. Skalnik. "Overexpression of CCAAT Displacement Protein Represses the Promiscuously Active Proximal gp91phox Promoter." Blood 94, no. 9 (1999): 3151–60. http://dx.doi.org/10.1182/blood.v94.9.3151.421k38_3151_3160.

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CCAAT displacement protein (CDP) is a transcriptional repressor that restricts expression of the gp91phox gene to mature myeloid cells. CDP interacts with multiple sites within the −450 to +12 bp human gp91phox promoter, and down-regulation of CDP DNA-binding activity is required for induction of gp91phox transcription in mature phagocytes. Truncation of the gp91phox promoter to −102 to +12 bp removes 4 CDP-binding sites and reveals a promiscuous promoter activity that is active in some nonphagocytic cells. A cis-element at −90 bp is required for derepressed transcription and serves as a bindi
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23

Ribble, Thomas G., Michael H. Santare, and Freeman Miller. "Stresses in the Growth Plate of the Developing Proximal Femur." Journal of Applied Biomechanics 17, no. 2 (2001): 129–41. http://dx.doi.org/10.1123/jab.17.2.129.

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Finite element models of the proximal femur at birth, 2 years of age, and at 8 years of age were constructed to investigate stress patterns under different loading conditions. These loading conditions represent typical activities of a normal developing child and abnormal activity associated with muscle spasticity. The hypothesis is that the shear stresses in the growth plate correlate with the neckshaft angle as associated with valgus and normal development. Loads for the finite element models were derived from a separate muscle model used to calculate the forces across the hip joint for an ar
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24

Lu, Yan Hua, De Hong Cheng, and Zhao Dan Yang. "Characterization and Properties of Antheraea pernyi Silk Finished with Reactive Quaternary Ammonium Salt of Chitosan." Advanced Materials Research 175-176 (January 2011): 288–93. http://dx.doi.org/10.4028/www.scientific.net/amr.175-176.288.

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In order to obtain a water soluble and reactive chitosan derivative, quaternary ammonium salt groups and acrylamidomethyl groups were introduced to chitosan by two steps. The chitosan derivative, reactive quaternary ammonium salt of chitosan, was then applied to Antheraea pernyi (A. pernyi) silk by padding and curing method. FT-IR, XRD and SEM were used to characterize the structure of A. pernyi silk before and after treatment. The peak in FT-IR spectra at 1480 cm-1 and 1650 cm-1 revealed the crosslinking reactions of A. pernyi silk fibroin and reactive quaternized chitosan. The XRD results in
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25

Berdiyarov, B., Sh Khojiev, O. Nuraliyev, B. Mirsaotov, S. Mirsaotov, and Z. Osmanov. "Monitoring the oxygen removal process at the final stage of melting steel." Journal of Physics: Conference Series 2131, no. 2 (2021): 022071. http://dx.doi.org/10.1088/1742-6596/2131/2/022071.

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Abstract This article deals with removing oxygen at the final stage of steel smelting in arc steel-making furnaces. It is shown that the remaining oxygen during crystallization forms floccules and significantly reduces the quality of the finished metal. During the subsequent metal processing by pressure on these floccules, the metal is torn apart and makes it impossible to obtain a steel sheet. Deoxidation is performed with expensive ferroalloys, and their consumption must be minimized. To achieve economic efficiency, it has been proposed to use recycled aluminum slag as a relatively inexpensi
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26

Le, Taihe, Pingli Mao, Wenyi Hu, and Qichi Le. "Effect of Sm Addition on the Electrochemical Behavior and Discharge Performance of Mg-1Sn-1Ca-0.3Mn Alloy as Mg-Air Battery Anodes." Journal of The Electrochemical Society 171, no. 1 (2024): 010506. http://dx.doi.org/10.1149/1945-7111/ad14ce.

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Sm element is a relatively inexpensive rare Earth element. The effect of Sm content on the microstructure, electrochemical behavior and discharge performance of Mg-1Sn-1Ca-0.3Mn (TX11) alloy was investigated through scanning electron microscopy (SEM), electrochemistry workstation and Mg-air battery tests. Results reveal the addition of Sm does not change second-phase morphology of TX11 alloy, CaMgSn and Mg2Ca phases solidly dissolves Sm elements. The electrochemistry results depict that Sm addition deteriorates the corrosion resistance and electrochemical activity of TX11 alloy, which is attri
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27

Pavlykivska, O., and U. Plekan. "Social reporting as an element of business strategy of market entities." Galic'kij ekonomičnij visnik 68, no. 1 (2021): 62–69. http://dx.doi.org/10.33108/galicianvisnyk_tntu2021.01.062.

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The essence of social reporting is investigated. It is proved that there is a close relation between socially responsible activities and accounting because the accountant has general responsibility for the reliability, evaluation and disclosure of information, including information that is related to social problems. Moreover this type of activity is based on self-regulation (lack of formalization due to insufficiency of normative base), the reflection of social activity indicators in the accounting depends on the accountant subjective opinion and, relatively, the latter is responsible for thi
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28

Qiao, Weizhi, Zhenyu Wang, Xiang Gao, et al. "Design Simulation and Structure Optimization of Plunger Assembly Closing." Journal of Physics: Conference Series 2029, no. 1 (2021): 012012. http://dx.doi.org/10.1088/1742-6596/2029/1/012012.

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Abstract Hydraulic motors and pumps are the core components in hydraulic systems. The plunger assembly is a key component for the realization of the function of the axial piston pump and motor. The coupling between the slipper and the plunger body is completed through the closing process. With the application of computational science and finite element technology, DEFORM-3D metal forming process simulation is used to establish the corresponding closing device model of the plunger assembly. Through simulation, we analyze the change law of metal flow during plastic deformation process, and carry
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29

Belhumeur, P., J. Lanoix, Y. Blais, D. Forget, A. Steyaert, and D. Skup. "Action of spontaneously produced beta interferon in differentiation of embryonal carcinoma cells through an autoinduction mechanism." Molecular and Cellular Biology 13, no. 5 (1993): 2846–57. http://dx.doi.org/10.1128/mcb.13.5.2846-2857.1993.

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In the current study, we have addressed the role of interferons (IFNs) in controlling the differentiation of pluripotent P19 embryonal carcinoma (EC) cells. Blocking IFN activity in the culture medium of differentiating cells with antibodies leads to a strong decrease in the degree of differentiation. The antibodies are active for a relatively short time. During this time, IFN-beta mRNA can be detected in the differentiating cells, as can increases of IFN stimulation response element-binding activity and NF-KB. The timing of IFN action also coincides with the accumulation of cytoplasmic double
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30

Belhumeur, P., J. Lanoix, Y. Blais, D. Forget, A. Steyaert, and D. Skup. "Action of spontaneously produced beta interferon in differentiation of embryonal carcinoma cells through an autoinduction mechanism." Molecular and Cellular Biology 13, no. 5 (1993): 2846–57. http://dx.doi.org/10.1128/mcb.13.5.2846.

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In the current study, we have addressed the role of interferons (IFNs) in controlling the differentiation of pluripotent P19 embryonal carcinoma (EC) cells. Blocking IFN activity in the culture medium of differentiating cells with antibodies leads to a strong decrease in the degree of differentiation. The antibodies are active for a relatively short time. During this time, IFN-beta mRNA can be detected in the differentiating cells, as can increases of IFN stimulation response element-binding activity and NF-KB. The timing of IFN action also coincides with the accumulation of cytoplasmic double
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31

Bruce, W. B., and W. B. Gurley. "Functional domains of a T-DNA promoter active in crown gall tumors." Molecular and Cellular Biology 7, no. 1 (1987): 59–67. http://dx.doi.org/10.1128/mcb.7.1.59-67.1987.

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Promoter domains required for transcriptional expression of the 780 gene of T-right (pTi15955) were identified by deletion mutagenesis. Accurate quantitation of transcriptional activity of a series of 5' and internal deletion mutants was achieved by using a double gene vector containing a reference 780 gene as an internal standard. Results of the 5' deletions delineated an activator element located between -440 and -229 base pairs (bp) from the start of transcription. Removal of this region resulted in a 100-fold decrease in promoter activity. Two relatively small internal deletion/substitutio
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32

Bruce, W. B., and W. B. Gurley. "Functional domains of a T-DNA promoter active in crown gall tumors." Molecular and Cellular Biology 7, no. 1 (1987): 59–67. http://dx.doi.org/10.1128/mcb.7.1.59.

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Promoter domains required for transcriptional expression of the 780 gene of T-right (pTi15955) were identified by deletion mutagenesis. Accurate quantitation of transcriptional activity of a series of 5' and internal deletion mutants was achieved by using a double gene vector containing a reference 780 gene as an internal standard. Results of the 5' deletions delineated an activator element located between -440 and -229 base pairs (bp) from the start of transcription. Removal of this region resulted in a 100-fold decrease in promoter activity. Two relatively small internal deletion/substitutio
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33

Sabath, DE, KM Koehler, WQ Yang, K. Patton, and G. Stamatoyannopoulos. "Identification of a major positive regulatory element located 5' to the human zeta-globin gene." Blood 85, no. 9 (1995): 2587–97. http://dx.doi.org/10.1182/blood.v85.9.2587.bloodjournal8592587.

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The function of the zeta-globin promoter was studied using a series of zeta-globin promoter deletion constructs to drive luciferase expression in transiently transfected human erythroleukemia cells. The promoters were used without enhancers, or with enhancers derived from the beta-globin locus control region and the alpha-globin HS-40 enhancer. When transfected into K562 cells, which express zeta-globin, comparable amounts of activity were obtained from the -557 and -417 zeta-luciferase constructs and the alpha-luciferase constructs when no enhancers or the alpha-globin locus enhancers were us
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34

GUM, James R., James W. HICKS, and Young S. KIM. "Identification and characterization of the MUC2 (human intestinal mucin) gene 5′-flanking region: promoter activity in cultured cells." Biochemical Journal 325, no. 1 (1997): 259–67. http://dx.doi.org/10.1042/bj3250259.

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The initiation point for MUC2 gene transcription is located within a 7000-base GC-rich region of the mucin gene cluster found on chromosome 11p15.5. The promoter activity of the 5′-flanking region of the MUC2 gene was examined following its cloning into the luciferase-producing pGL2-Basic reporter vector. A short segment comprising bases -91 to -73 relative to the start of transcription was found to be important for basal promoter activity in all cell lines tested. Electrophoretic mobility shift assays demonstrated nuclear protein binding to this region, which contains the consensus CACCC moti
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35

Athaya, Athaya, and Wahyudin Wahyudin. "Pemasaran Efektif di Era Digital: Membuka Toko Online di Platform Marketplace Indonesia." Jurnal PKM Manajemen Bisnis 4, no. 1 (2024): 16–22. http://dx.doi.org/10.37481/pkmb.v4i1.671.

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Digital marketing has become an important element in a company's marketing strategy in the current digital era. This also applies to small and medium enterprises (SMEs). One of the popular digital marketing platforms in Indonesia is the marketplace. Marketplaces offer various benefits for SMEs, such as ease of managing online stores, access to a wide market, and relatively affordable costs. This community service activity aims to increase the knowledge and skills of SMEs in opening and managing online stores on the Indonesian marketplace platform. This activity is carried out using training an
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36

Eanes, W. F., L. Katona, and M. Longtine. "Comparison of in vitro and in vivo activities associated with the G6PD allozyme polymorphism in Drosophila melanogaster." Genetics 125, no. 4 (1990): 845–53. http://dx.doi.org/10.1093/genetics/125.4.845.

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Abstract Earlier studies of the A and B allozymes at the G6pd locus show a differential ability of the genotypes to suppress the loss of viability associated with a low activity 6-phosphogluconate dehydrogenase mutation, 6Pgdlo1. This observation indicates a relatively lower activity for the A allozyme genotype, but it is not known if this level of suppression required a large difference in in vivo activity. To clarify this difference an analysis of the biochemical properties of the purified allozymes was carried out, as well as an analysis of the activity level associated with an original low
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Bahari, Md Fuad, Abdul Rahman Omar, Darius Gnanaraj Solomon, Nor Hayati Saad, and Isa Halim. "Ergonomics Analysis of Muscle Activity of Workers in a Metal Stamping Industry." Scientific Research Journal 3, no. 2 (2006): 31. http://dx.doi.org/10.24191/srj.v3i2.5668.

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Occupational health is considered as a crucial element in almost every Small and Medium Industries (SMIs) and it is believed to be one of vital challenges that can influence productivity and competitiveness. It has been known that the metal stamping industry involved a lot of materials handling tasks such as carrying stamped parts from machine to packaging section, transferring moulds from tools store to machines, sorting the finished products and others. Appropriate materials handling equipments are not often provided in SMIs because of the limitation of capital and lack of ergonomics awarene
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38

Silva, Gisele C. R., Dali Qian, Robert Pace, et al. "Promotional Effect of Cu, Fe and Pt on the Performance of Ni/Al2O3 in the Deoxygenation of Used Cooking Oil to Fuel-Like Hydrocarbons." Catalysts 10, no. 1 (2020): 91. http://dx.doi.org/10.3390/catal10010091.

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Inexpensive Ni-based catalysts can afford comparable performance to costly precious metal formulations in the conversion of fat, oil, or greases (FOG) to fuel-like hydrocarbons via decarboxylation/decarbonylation (deCOx). While the addition of certain metals has been observed to promote Ni-based deCOx catalysts, the steady-state performance of bimetallic formulations must be ascertained using industrially relevant feeds and reaction conditions in order to make meaningful comparisons. In the present work, used cooking oil (UCO) was upgraded to renewable diesel via deCOx over Ni/Al2O3 promoted w
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39

P., Radha. "STUDY ON WOMEN SPORTS IN INDIA." Shanlax International Journal of Arts, Science and Humanities 6, S2 (2019): 52–58. https://doi.org/10.5281/zenodo.2566947.

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<em>Women in Sport&rsquo; has been a topic virtually ignored by most scholars and thus female sport participation has been a relatively undeveloped area of research. Sex role, stereotyping, male research bias and the reward structure of society have contributed to this neglect. Currently, sport for women represents a fast growing changing element in Indian culture, and recent trends have sparked a need for knowledge about the female sport participation</em>
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40

Uchitel, A. D., Yu A. Malinovskyi, G. V. Danilina, N. V. Voytenko, D. P. Rybak, and S. Y. Datsenko. "Parametric effects in the frictional interaction of a tool with a billet in the process of its treatment by pressure." Metallurgicheskaya i gornorudnaya promyshlennost, no. 1 (2019): 17–30. http://dx.doi.org/10.33101/s001-1902913518.

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Purpose. Justification of the influence of pulsating dynamic loads in the surface layers of parts obtained by plastic deformation methods on the quality of finished products during cold rolling, knurling, running in, drawing and stamping. Research methodology. A schematization was adopted in which the workpiece or part is an anisotropic medium elastically bonded along the surface of the junction of external reinforced layers with the internal mass of the part. On the basis of the proposed physical model, conditions were found under which under the action of cyclic surface loads, violations of
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41

OLIVERA, ŠAUPERL, ZEMLJIČ LIDIJA FRAS, JULIJA VOLMAJER VALH, and JASNA TOMPA. "Textile cosmetic pads based on psyllium and protein colloid in combination with the horsetail extract." Industria Textila 70, no. 01 (2019): 21–24. http://dx.doi.org/10.35530/it.070.01.1479.

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The basic purpose of this research work was to develop a care/healing cosmetic pads where a horsetail water extract was selected as a healing/care compound. Together with this, psyllium and keratin (protein colloid) were used as natural compounds capable to form a gel-like structure in aqueous media, so they were explored as i) carriers of a care/healing compound (horsetail extract), and as ii) “binding element” (due to relatively high viscosity) in-between the healing compound and the textile substrate (i.e. non-woven viscose) itself. Such functionalization system was relatively easily applie
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42

Ershov, Mikhail, Ludmila Kuranova, Irina Smirnova, and Julia Alloyarova. "Determination of kelp (Laminaria digitata) technological characteristics depending on the drying method." BIO Web of Conferences 71 (2023): 01060. http://dx.doi.org/10.1051/bioconf/20237101060.

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The paper considers four methods of drying kelp (Laminaria digitata): convective dehydration at an air temperature of minus 5 oС, relative air humidity of 55 and 90 %; vacuum drying at a metal carrier temperature of 20°C and a vacuum depth of 250 Pa; convective dehydration at an air temperature of 20°C and a relative air humidity of 35 %. In dried algae, the final moisture content, water activity, and strength characteristics were evaluated. To determine the swelling coefficient, dry algae were pre-crushed. It was established that at a temperature of minus 5°C and a relative air humidity of 90
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Faure, P., P. Corticelli, M. J. Richard, et al. "Lipid peroxidation and trace element status in diabetic ketotic patients: influence of insulin therapy." Clinical Chemistry 39, no. 5 (1993): 789–93. http://dx.doi.org/10.1093/clinchem/39.5.789.

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Abstract Lipid peroxidation is known to accelerate aging and microvascular lesions in diabetic patients. We studied the acute influence of improved glycemic control on the concentrations of plasma lipid peroxidation intermediates [malondialdehydes (MDA), organic hydroperoxides (OHP)] in ketotic insulin-dependent diabetic patients, as well as the interplay of enzymes such as glutathione peroxidase (GPX) and CuZn superoxide dismutase (CuZn-SOD), and trace elements (Zn, Se, Cu) postulated to be involved in free radical protection. These plasma components were measured on the first day of hospital
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44

Pesacreta, T. C., A. B. Bennett, and W. J. Lucas. "Spectrophotometric and cytochemical analyses of phosphatase activity in Beta vulgaris L." Journal of Histochemistry & Cytochemistry 34, no. 3 (1986): 327–38. http://dx.doi.org/10.1177/34.3.2419391.

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Spectrophotometric and cytochemical methods were used to investigate the localization and/or the sensitivity of phosphatase activities in aldehyde-fixed beet leaves and membrane fractions. The nonspecific acid phosphatase substrates, p-nitrophenyl phosphate and beta-glycerol phosphate, each exhibited unique spectrophotometric patterns of hydrolysis as a function of pH. Additionally, beta-glycerol phosphatase activity was primarily present on the tonoplast, whereas p-nitrophenyl phosphatase was present on the plasma membrane. Because of the unique pH response of each enzyme and their different
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45

Сафонов, А. О. "ANALYSIS OF THE APPLICATION OF HETEROGENEOUS ACID CATALYSTS IN BIOFUEL PRODUCTION." Южно-Сибирский научный вестник, no. 3(55) (June 30, 2024): 10–16. http://dx.doi.org/10.25699/sssb.2024.55.3.002.

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Для производства биодизельного топлива путем переэтерификации растительных масел можно применять кислотные катализаторы на основе соляной или серной кислот. Сейчас чаще используют гомогенные щелочные катализаторы, обеспечивающие высокую конверсию готового продукта за сравнительно небольшую продолжительность процесса. Но такие катализаторы требуют больших затрат на выделение из смеси продуктов для повторного использования. Также гомогенные кислотные катализаторы склонны вызывать коррозию оборудования. Для решения этих проблем целесообразно применять твердые гетерогенные катализаторы. Они не выз
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46

V, Ramamurthy. "Production & Characterisation of Fermented Coconut Water and a Report on Its Health Benefits." Food Science & Nutrition Technology 7, no. 1 (2022): 1–5. http://dx.doi.org/10.23880/fsnt-16000278.

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Coconut water known as nutritive liquid and a natural medium for microbial growth is obtained from the endosperm of coconuts (Cocos nucifera) and is largely consumed in tropical countries. Fermentation with known culture of microbes gives desirable quality and more shelf life to this perishable drink. Fermentation of coconut water to prepare a beverage of high health benefits and commercial value was attempted. Tender coconut was fermented with Saccharomyces cerevisiae yeast and observed for the fermentative changes in around 15 days. The sensory analysis of obtained fermented drink was done t
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47

Povalyashko, E. S. "External relations of subnational regions of unitary countries in the EU: activity and determining factors." Abyss (Studies in Philosophy, Political science and Social anthropology), no. 1 (March 15, 2023): 139–47. http://dx.doi.org/10.33979/2587-7534-2023-1-139-147.

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The subnational level external relations within the EU are an element of the political system. Although the unitary countries regions have less experience, resources, etc., than the subjects of federations they are also involved in the process. The article presents the main results of the analysis of the unitary countries regions external relations activity within the EU, as well as determining factors. In particular, it is concluded that the regulation of the issue at the state level is of fundamental importance. Also the region's belonging to a country with a relatively rich economy and long
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48

Kulozik, AE, A. Bellan-Koch, S. Bail, E. Kohne, and E. Kleihauer. "Thalassemia intermedia: moderate reduction of beta globin gene transcriptional activity by a novel mutation of the proximal CACCC promoter element." Blood 77, no. 9 (1991): 2054–58. http://dx.doi.org/10.1182/blood.v77.9.2054.2054.

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Abstract A patient with homozygous beta thalassemia of German/Italian descent was found to be doubly heterozygous for the common IVS1–110 G----A mutation of the beta globin gene and for a novel C----T mutation of the proximal CACCC-box of the beta globin gene promoter at position -87 relative to the transcription start site (cap). Transcription analysis in an HeLa cell transfection assay indicated a 45% to 51% residual activity of the gene with the -87 C----T mutation relative to normal, further underlining the physiologic role of the affected promoter element. The finding of an only moderatel
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49

Kulozik, AE, A. Bellan-Koch, S. Bail, E. Kohne, and E. Kleihauer. "Thalassemia intermedia: moderate reduction of beta globin gene transcriptional activity by a novel mutation of the proximal CACCC promoter element." Blood 77, no. 9 (1991): 2054–58. http://dx.doi.org/10.1182/blood.v77.9.2054.bloodjournal7792054.

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A patient with homozygous beta thalassemia of German/Italian descent was found to be doubly heterozygous for the common IVS1–110 G----A mutation of the beta globin gene and for a novel C----T mutation of the proximal CACCC-box of the beta globin gene promoter at position -87 relative to the transcription start site (cap). Transcription analysis in an HeLa cell transfection assay indicated a 45% to 51% residual activity of the gene with the -87 C----T mutation relative to normal, further underlining the physiologic role of the affected promoter element. The finding of an only moderately reduced
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50

Putland, R. A., T. A. Sassinis, J. S. Harvey, et al. "RNA Destabilization by the Granulocyte Colony-Stimulating Factor Stem-Loop Destabilizing Element Involves a Single Stem-Loop That Promotes Deadenylation." Molecular and Cellular Biology 22, no. 6 (2002): 1664–73. http://dx.doi.org/10.1128/mcb.22.6.1664-1673.2002.

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ABSTRACT Granulocyte colony-stimulating factor (G-CSF) mRNA contains two distinct types of cis-acting mRNA destabilizing elements in the 3′-untranslated region. In addition to several copies of the AU-rich element the G-CSF mRNA also contains a destabilizing region that includes several predicted stem-loop structures. We report here that the destabilizing activity resides in a single stem-loop structure within this region. A consensus sequence for the active structure has been derived by site-directed mutagenesis, revealing that a three-base loop of sequence YAU and unpaired bases either side
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