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Dissertations / Theses on the topic 'Relaxivita'

Author: Grafiati

Published: 4 June 2021

Last updated: 18 February 2022

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1

Botz, Alexandra. "Complexes peptide-lanthanide : vers de nouvelles sondes luminescentes et magnétiques de l'ADN." Thesis, Université Grenoble Alpes (ComUE), 2016. http://www.theses.fr/2016GREAV044.

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L’ADN est une molécule biologique essentielle, assurant le support et le transfert de l’information génétique des êtres vivants, et impliquée dans de nombreux processus d’interactions. L’élaboration d’outils moléculaires efficaces capables d’interagir avec l’ADN et de mettre en évidence cette interaction est donc un domaine de recherche d’intérêt majeur pour la compréhension d’événements biologiques essentiels et pour le diagnostic médical. Grâce à leurs propriétés spectroscopiques et magnétiques particulières, les ions lanthanides (Ln3+) s’avèrent être d’excellents candidats dans l’élaboratio

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2

Moula, Karimdjy Maria. "Nouveaux marqueurs à base de lanthanides pour l'imagerie moléculaire et l'analyse biomédicale." Thesis, Université Grenoble Alpes (ComUE), 2015. http://www.theses.fr/2015GREAV046/document.

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L'IRM (Imagerie par Résonance Magnétique) est une technique de choix pour l'imagerie moléculaire, soit la visualisation d'événements biologiques à l'échelle moléculaire. En effet, elle est non invasive et possède une haute résolution. Cependant, elle manque de sensibilité. L'utilisation d'agents de contraste commerciaux, qui sont pour la plupart des chélates de Gd(III), peut pallier à ce problème lors d'examens cliniques mais ils ne sont pas assez efficaces en vue de l'imagerie moléculaire. Leur efficacité, définie par leur relaxivité, peut être améliorée en optimisant les paramètres qui la go

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3

Messeri, Dimitri. "Targeted and high relaxivity contrast agents." Thesis, Durham University, 2001. http://etheses.dur.ac.uk/1246/.

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4

Chauvin, Thomas. "Développement d'agents de contraste intelligents pour l'Imagerie par Résonance Magnétique (IRM)." Thesis, Orléans, 2010. http://www.theses.fr/2010ORLE2011.

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L’Imagerie par Résonance Magnétique est une des techniques de diagnostic les plus performantes. Parmi les perspectives d’avenir, les applications en imagerie moléculaire avec l’utilisation d’agents de contraste intelligents sensibles à divers paramètres physico-chimiques sont particulièrement attrayantes.Dans cette thèse, nous présentons la synthèse et la caractérisation physico-chimique de nouveaux complexes de lanthanide dans le but de développer des agents de contraste sensibles à l’activité enzymatique ou la présence d’ions calcium. Les premiers complexes sont basés sur le concept de coupl

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5

Giardiello, Marco. "High relaxivity contrast agents for magnetic resonance imaging (MRI)." Thesis, University of Leicester, 2007. http://hdl.handle.net/2381/7701.

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The development of Gd(III)-based contrast agents for MRI applications has intensified in recent years due to the paramagnetic ion’s long electron spin relaxation time and large effective magnetic moment, µeff. Secondly, the exploitation of the long lived luminescent properties of the Ln(III) ions has lead to the development of luminescent lanthanide probes for sensing, time resolved immunoassay and imaging applications. Herein a series of novel Ln-DO3A based complexes are reported. Modulation of relaxivity, r1, (Gd) and emission intensity (Eu, Tb, Sm and Dy) has been achieved in three ways: Fi

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6

Wartenberg, Nicolas. "Développement de nano-traceurs à base d’organolanthanides pour applications biologiques et marquage de matériaux." Thesis, Lyon 1, 2012. http://www.theses.fr/2012LYO10224/document.

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Ce travail de thèse traite de l’élaboration de nanoparticules luminescentes à based’organolanthanides pour des applications d’imagerie biomédicale ou de marquage pour la lutte anticontrefaçon. Les organolanthanides ont été incorporés sans liaison covalente afin de préserver leursremarquables propriétés de luminescence et leur stabilité chimique. Deux types de nanoparticulesont été étudiés, des particules de latex et des billes de silice qui ont toutes les deux été synthétiséesen milieu hétérogène.La silice a été synthétisée par un procédé sol-gel en microémulsion inverse. Deux organolanthanide

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7

Haigh, Julian Saunders. "Investigation in to the Effect of Spin Locking on Contrast Agent Relaxivity." PDXScholar, 2015. http://pdxscholar.library.pdx.edu/open_access_etds/2496.

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The current trend in magnetic resonance imaging (MRI) is towards higher external magnetic field strengths (B0) to take advantage of increased sensitivity and signal to noise ratio (SNR). Unfortunately, as (B0) increases the effectiveness (relaxivity) of clinical gadolinium (Gd3+)-based contrast agents (CAs) administered to enhance image contrast is significantly reduced. Excellent soft tissue contrast can be generated with current agents despite their non-optimum relaxivities but necessitates large doses. The limits of detection of a CA at high B0 fields can be lowered by recovering the lost r

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8

Hsieh, Vivian Ph D. Massachusetts Institute of Technology. "High relaxivity biomolecule based contrast agents engineered for molecular functional magnetic resonance imaging." Thesis, Massachusetts Institute of Technology, 2016. http://hdl.handle.net/1721.1/104206.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Chemical Engineering, 2016.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (pages 71-84).<br>Magnetic resonance imaging (MRI) is a powerful neuroimaging tool that allows non-invasive visualization of the brain with high spatial and temporal resolution. Research on MRI contrast agents and their application to problems in neuroscience is burgeoning, and there is particular interest in developing MRI agents that are sensitive to time varying components of neurophysiology. Relatively recent advanc

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9

ABEY, JANE E. "SYNTHESIS, CHARACTERIZATION AND RELAXIVITY OF POLYMERIC GADOLINIUM CHELATES AS POTENTIAL MRI CONTRAST AGENTS." University of Cincinnati / OhioLINK, 2004. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1084460201.

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10

Michelin, Clement. "Synthèse de nouveaux agents bimodaux hydrosolubles pour l'IRM, l'imagerie nucléaire, l'imagerie biphotonique et la génération de second harmonique." Thesis, Dijon, 2015. http://www.theses.fr/2015DIJOS014/document.

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Le travail présenté dans ce mémoire de thèse avait pour but de synthétiser de nouveaux composés pour des applications en imagerie médicale. La première partie porte sur la synthèse de ligands hétéroleptiques pour la chélation de deux métaux différents en vue d’une utilisation dans deux types d’imagerie. Pour cela, nous avons d’abord synthétisé des porphyrines. Ces molécules sont connues pour la chélation de nombreux métaux de transition et notamment le cuivre, dont l’isotope cuivre-64 est un radioémetteur β+ utilisable en Tomographie par Émission de Positron (TEP). Ces porphyrines ont été coup

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11

Benjamin, Michael. "Synthesis, Characterization, and Determination of Relaxivities for Glycoamido-DTPA Polymers for Use as MRI Contrast Agents." University of Cincinnati / OhioLINK, 2006. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1154109396.

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12

Morell, Arvid. "Quantitative Tracer Based MRI Perfusion : Potentials and Limitations." Doctoral thesis, Uppsala universitet, Enheten för radiologi, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-171901.

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Tracer based MRI perfusion measurements is a clinically useful tool to assess regional distributions of tissue blood flow and volume. The method may be based on any of the three relaxation mechanisms T1, T1 and T2*, the latter denoted DSC-MRI being the most common. The primary aim of this work was to study the feasibility of obtaining quantitative estimates using these methods. 1) Feasibility of DSC-MRI for kidneys using an iron oxide based contrast agent and the influence of secondary relaxation effects on the results, part of a clinical phase II trial: The method proved feasible and the unde

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13

Skinner, Philip J. "Synthesis and application of cyclodextrin conjugates." Thesis, Durham University, 1999. http://etheses.dur.ac.uk/4542/.

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Cyclodextrins, a family of compounds formed from a cyclic array of glucose monomers, contain a hydrophobic cavity which displays selective complexation of size specific guests. This selective molecular recognition is critical to the development of successful chemosensors. A selection of cyclodextrin-conjugates have been designed to report complexation of guests into the cyclodextrin cavity by optical and electrochemical means. Alkylated cyclodextrins containing a single linker group have been synthesised allowing the development of two cyclen-appended cyclodextrin conjugates and their lanthani

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14

Xue, Shenghui. "Design of Novel Protein-based MRI Contrast Agernets with High Relaxivity and Stability for Biomedical Imaging." Digital Archive @ GSU, 2013. http://digitalarchive.gsu.edu/biology_diss/133.

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Magnetic resonance imaging (MRI) is the leading imaging technique for disease diagnostics. MRI contrast agents facilitate MRI technique to obtain tissue-specific image with improved sensitivity and signal-to-noise ratio. However, the applications of current MRI contrast agents are hampered by their uncontrolled blood circulation time, low relaxivity, and low specificity. To address such need, I have developed a series of analitical methods to determine and evaluate the strong metal binding affinity and metal selectivity of developed protein-based contrast agents (ProCAs). In addition, we have

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15

Abey, Jane E. "Synthesis, characterization and relaxivity of polymeric gadolinium (III) chelates as potential magnetic resonance imaging contrast agents." Cincinnati, Ohio : University of Cincinnati, 2004. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=ucin1084460201.

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16

Subra, Guy. "Optimisation de structures en série alkylamido-tempo en vue d'une amélioration de la relaxivité en milieu protéique." Montpellier 1, 1996. http://www.theses.fr/1996MON13513.

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17

Mitchell, Chad A. "Besign-directed measurements of B1 heterogeneity and spin-lattice relaxation for 8 Tesla MRI." The Ohio State University, 2004. http://rave.ohiolink.edu/etdc/view?acc_num=osu1095684374.

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18

Liu, Huabing, Marcel Nogueira D’Eurydice, Sergei Obruchkov, and Petrik Galvosas. "Pore length scales and pore surface relaxivity of sandstone determined by internal magnetic fields modulation at 2 MHz NMR." Universitätsbibliothek Leipzig, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-178759.

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Pore length scales and pore surface relaxivities of sandstone were studied on a 2 MHz Rock Core Analyzer in this work. To determine the pore length scales of rock cores, high eigenmodes of diffusion equation were detected with optimized encoding periods in the presence of internal magnetic fields B in. The results were confirmed by a 64 MHz NMR system. Furthermore, this methodology was combined with relaxometry measurements , which provides the two-dimensional correlation of pore length with relaxation time and yield information on the surface relaxivity of rock cores. The estimated surface re

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19

Liu, Huabing, Marcel Nogueira D’Eurydice, Sergei Obruchkov, and Petrik Galvosas. "Pore length scales and pore surface relaxivity of sandstone determined by internal magnetic fields modulation at 2 MHz NMR." Diffusion fundamentals 22 (2014) 7, S. 1-5, 2014. https://ul.qucosa.de/id/qucosa%3A13487.

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Pore length scales and pore surface relaxivities of sandstone were studied on a 2 MHz Rock Core Analyzer in this work. To determine the pore length scales of rock cores, high eigenmodes of diffusion equation were detected with optimized encoding periods in the presence of internal magnetic fields B in. The results were confirmed by a 64 MHz NMR system. Furthermore, this methodology was combined with relaxometry measurements , which provides the two-dimensional correlation of pore length with relaxation time and yield information on the surface relaxivity of rock cores. The estimated surface re

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20

Laine, Sophie. "Complexes de lanthanide pour la détection d’activité enzymatique par IRM." Thesis, Orléans, 2016. http://www.theses.fr/2016ORLE2088/document.

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L’imagerie par résonnance magnétique trouve depuis ces dernières années des applications notables dans le domaine de l’imagerie moléculaire, qui représente un atout considérable pour l’investigation et la compréhension des processus biologiques. Des agents de contraste dits « intelligents » et spécifiques du processus physiologique que l’on souhaite détecter (pH, température, concentration en ion métallique, métabolite, etc.) sont alors développés. Cette thèse se concentre sur le développement et l’étude de nouveaux agents de contraste conçus pour la détection spécifique de l’activité enzymati

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21

Qiao, Jingjuan. "Targeted Molecular MR Imaging of HER2 and EGFR Using De Novo Designed Protein Contrast Agents." Digital Archive @ GSU, 2011. http://digitalarchive.gsu.edu/chemistry_diss/62.

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The application of magnetic resonance imaging (MRI) to non-invasively assess disease biomarkers has been hampered by lack of desired contrast agents with high relaxivity, targeting capability, and optimized pharmacokinetics. We developed a novel MRI probe which targets HER2, a biomarker for various cancers and a target for anti-cancer therapies. This multimodal HER2-targeted MRI probe integrates a rationally designed protein contrast agent with a high affinity HER2 affibody and near IR dye. Our probe can differentially monitor tumors with different HER2 levels in both cells and xenograft mice

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22

Donahue, Kathleen Marie. "Studies of GD-DTPA relaxivity and proton exchange rates in tissue with implications for MR imaging of regional myocardial perfusion." Thesis, Massachusetts Institute of Technology, 1993. http://hdl.handle.net/1721.1/12485.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Whitaker College of Health Sciences and Technology, 1993.<br>Includes bibliographical references (leaves 170-182).<br>by Kathleen Marie Donahue.<br>Ph.D.

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23

Maurizi, Lionel. "Elaboration de nanoparticules fonctionnelles : applications comme agents de contraste en IRM." Phd thesis, Université de Bourgogne, 2010. http://tel.archives-ouvertes.fr/tel-00656844.

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Les nanoparticules d'oxyde de fer de structure spinelle ouvrent de nombreuses voies dans le domaine biomédical. Parmi les applications possibles, les propriétés superparamagnétiques des cristallites d'une dizaine de nanomètres permettent de les utiliser pour le diagnostic médical, notamment en Imagerie par Résonance Magnétique (IRM).Ce travail a consisté à élaborer des suspensions colloïdales de nanoparticules de magnétite ou de maghémite (nommées USPIO pour Ultrasmall SuperParamagnetic Iron Oxide) compatibles avec les conditions physiologiques (pH = 7,4 et [NaCl] = 0,15 M).Par co-précipitatio

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24

Malikidogo, Kyangwi Patrick. "Agents de contraste pour la détection quantitative du Zn(II) par IRM." Thesis, Orléans, 2017. http://www.theses.fr/2017ORLE2074.

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L’Imagerie par Résonance Magnétique (IRM) est classiquement utilisée pour l’obtention d’images anatomiques et fonctionnelles. L’émergence de l’imagerie moléculaire, qui cherche à visualiser des modifications biochimiques apparaissant de manière plus précoces que les changements morphologiques, nécessite l’utilisation de sondes spécifiques du processus à détecter. Cela a conduit à la conception de nouveaux agents de contraste IRM « intelligents » à base de Gd(III). La détection du Zn(II) reste un enjeu important du fait de son rôle dans les processus physiologiques et son implication dans diver

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25

Wei, Lixia. "Development of a Novel Protein Based MRI Contrast Agent for Molecular Imaging of Prostate Cancer." Digital Archive @ GSU, 2010. http://digitalarchive.gsu.edu/biology_diss/75.

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Molecular Imaging provides new aspects in cancer diagnosis and treatment. With the ap-plication of imaging and biological techniques, molecular imaging can monitor molecular and cellular changes of different diseases. To interpret the mechanism of disease, more and more at-tention is focused on the development of new probes for molecular imaging. Magnetic resonance imaging (MRI) is a powerful, non-invasive clinical diagnostic tool with high spatial resolution without the limitation of the depth of tissues. Applications of MRI contrast agents can amply the MRI signal during imaging. Many studie

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26

White, Natalie. "Optimization of Expression and Purification Methods for the Study of Protein-Based Magnetic Resonance Imaging Contrast Agents." Digital Archive @ GSU, 2011. http://digitalarchive.gsu.edu/chemistry_theses/42.

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Magnetic Resonance Imaging instruments rely on a contrast agent to provide high-resolution images of tissues in vivo. However, current clinical contrast agents are hindered by low relaxivity and fast correlation time, necessitating high injection dosages. These concerns, among others, have driven the development of a class of protein-based contrast agents (ProCAs), by design of lanthanide binding sites into a scaffold protein. ProCA1 has a higher reported relaxivity and dosage efficiency than current contrast agents. In this study, expression and Glutathione-S-Transferase purification procedu

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27

Jiang, Jie. "Tuning Calcium Bindging Affinities with Related Biological Functions of Calmodulin and Designing Protein Based Contrast Agent." Digital Archive @ GSU, 2011. http://digitalarchive.gsu.edu/chemistry_diss/60.

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Calmodulin (CaM) is a ubiquitous intracellular protein that regulates biological activities of numerous enzymes and ion channels. Upon responding Ca2+ concentration change, Ca2+- dependent CaM activates the hydrolyzation of cGMP by PDE and Ca2+ releasing channel activity of ryanodine receptor. In this dissertation, a series of CaM variants were engineered to enhance Ca2+ binding affinities by increasing the number of negative charged residues in individual EF-hand. The capability of shifting the biphasic Ca2+-activation profile of RyR1 is significantly altered by changing Ca2+ binding affinity

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28

Ye, Youqing. "Gadolinium Endohedral Metallofullerenes for Future Magnetic Resonance Imaging Contrast Agents." Thesis, Virginia Tech, 2014. http://hdl.handle.net/10919/47781.

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Gadolinium endohedral metallofullerenes (EMFs) have shown the potential to become next generation magnetic resonance imaging (MRI) contrast agents due to their significantly improved efficiency and safety, as well as multi-day body retention which allows for a longer surgery and observation compared to current contrast agents. In Chapter 1, I have reviewed the development of gadolinium EMF based MRI contrast agents. In Chapter 2, I have described my study of Gd3N@C80 and Gd3N@C84 metallofullerenols as next generation MRI contrast agents. The metallofullerenols are synthesized and characterized

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29

Russ, Jennifer Lynn. "Studies of Solution Paramagnetic-Substrate Nuclear and Electron Intermolecular Interactions." Diss., Virginia Tech, 2006. http://hdl.handle.net/10919/27050.

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Advanced nuclear and electron magnetic resonance techniques (i.e. nuclear magnetic resonance (NMR), dynamic nuclear polarization (DNP), and magnetic resonance imaging (MRI)) were used to study the attitude and dynamics of TEMPO (2,2,6,6-tetramethylpiperidinyloxy)-substrate systems and the relaxivity properties of water-soluble trimetallic nitride template functionalized endohedral metallofullerenes (TNT-fMF). The attitude and average distance of interaction for each TEMPO-substrate system was determined from comparing density functional theory (DFT) calculation results with experimental hyper

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30

Hubbard, Kendra Lynette. "Purification and Structural Characterization of a Novel Class of Protein- Based Magnetic Resonance Imaging Contrast Agents." Digital Archive @ GSU, 2010. http://digitalarchive.gsu.edu/chemistry_theses/33.

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More than one-third of all Magnetic Resonance Imaging (MRI) scans employ image-enhancing contrast agents to increase the differential signal intensity between diseased and normal tissue. Because current clinical contrast agents exhibit low relaxivity (mM-1 s-1), low dose efficiency, and rapid secretion, we have designed a group of protein-based MRI contrast agents with multiple gadolinium binding sites. In this study, the developed purification method for Class ProCA-3 agents allows for a quick and cost-effective way to abstract up to 109 mg of pure, soluble protein from a 1L E. Coli cell pell

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31

Prado, Yoann. "Nanoparticules multicouches de réseaux de coordination magnétiques." Paris 11, 2010. http://www.theses.fr/2010PA112197.

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Ce travail porte sur la synthèse, la caractérisation chimique et structurale et l'étude des propriétés magnétiques de nanoparticules cœur-coquille de réseau de coordination à ponts. La première partie expose la synthèse de nanoparticules magnétiques CsNiIICrllI(CN)6 de différentes tailles qui présentent un blocage de l'aimantation en dessous d'une température variant de 4 à 30 K. L'étude des propriétés magnétiques de ces objets permet de déterminer les caractéristiques magnétiques de ce réseau (taille critique monodomaine, constante d'anisotropie). La seconde partie présente la synthèse de nan

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32

SILVA, Diogo Lins Alves e. "Avaliação das propriedades ótica e relaxométrica de quantum dots de CdTe contendo íons gadolínio." Universidade Federal de Pernambuco, 2014. https://repositorio.ufpe.br/handle/123456789/18300.

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Wallace, Ashley J. "pH-triggered Self-Assembly of a PEGylated Peptide Amphiphilic Contrast Agent." The Ohio State University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=osu1500485484867638.

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Eggenspiller, Antoine. "Porphyrines et tétraazamacrocycles dérivés du DOTA : association de deux ligands pour la chélation de métaux d'intérêt en imagerie médicale multimodale." Phd thesis, Université de Bourgogne, 2012. http://tel.archives-ouvertes.fr/tel-00873315.

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Le travail présenté dans ce mémoire avait pour but de synthétiser de nouvelles molécules dont l'architecture donne accès à des complexes hétérobimétalliques aux propriétés intéressantes pour l'imagerie médicale multimodale. Dans ce manuscrit plusieurs points principaux ont donc été abordés. La première partie de se travail porte sur la synthèse et la caractérisation des ligands. Nous décrivons dans ce manuscrit la synthèse de cinq nouveaux ligands hétérobismacrocycliques basés sur l'association d'une porphyrine et d'un ou de plusieurs dérivés du cyclène. Ces ligands présentent la particularité

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35

Bonnet, Célia. "Complexation des cations lanthanides trivalents par des ligands d'origine biologique pour l'IRM : structure, thermodynamique et méthodes." Phd thesis, Université Joseph Fourier (Grenoble), 2006. http://tel.archives-ouvertes.fr/tel-00089144.

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La complexation des ions lanthanides(III) par de nouveaux ligands dont la sphère de coordination oxygénée est montée sur une plateforme à base d'unités sucres ou acides aminés est étudiée. Malgré des masses moléculaires relativement faibles, ces complexes induisent des relaxivités élevées inattendues, en particulier à haut champ.<br />Les ligands ACX et BCX, dérivés acides d'Α- et Β-cyclodextrines modifiées, forment des complexes mono et bimétalliques avec les Ln(III). Les complexes LnACX ou LnBCX ont des affinités similaires à celle de ligands triacides. La structure à l'état solide du comple

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36

Wartenberg, Nicolas. "Développement de nano-traceurs à base d'organolanthanides pour applications biologiques et marquage de matériaux." Phd thesis, Université Claude Bernard - Lyon I, 2012. http://tel.archives-ouvertes.fr/tel-00987047.

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Ce travail de thèse traite de l'élaboration de nanoparticules luminescentes à based'organolanthanides pour des applications d'imagerie biomédicale ou de marquage pour la lutte anticontrefaçon. Les organolanthanides ont été incorporés sans liaison covalente afin de préserver leursremarquables propriétés de luminescence et leur stabilité chimique. Deux types de nanoparticulesont été étudiés, des particules de latex et des billes de silice qui ont toutes les deux été synthétiséesen milieu hétérogène.La silice a été synthétisée par un procédé sol-gel en microémulsion inverse. Deux organolanthanide

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37

Dahlström, Nils. "Quantitative Evaluation of Contrast Agent Dynamics in Liver MRI." Doctoral thesis, Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-60264.

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The studies presented here evaluate the biliary, parenchymal and vascular enhancement effects of two T1-shortening liver-specific contrast agents, Gd-BOPTA and Gd-EOB-DTPA, in Magnetic Resonance Imaging (MRI) of healthy subjects and of patients. Ten healthy volunteers were examined with both contrast agents in a 1.5 T MRI system using three-dimensional gradient echo sequences for dynamic imaging until five hours after injection. The enhancement of the common hepatic duct in contrast to the liver parenchyma was analyzed in the first study. This was followed by a study of the image contrasts of

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Jahanbin, Tania. "Conception et développement in vitro d'agents de contraste hautement efficace en IRM : apport de la dynamique moléculaire sur le signal RMN." Toulouse 3, 2014. http://thesesups.ups-tlse.fr/2566/.

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L'objectif du travail de thèse est de concevoir et développer 2 classes d'agent de contraste (AC) intrinsèquement efficace en IRM. La première classe comprend le Gd (III)-méso-tétra (4-pyridyl) porphyrine (Gd (TPyP)) macromoléculaire. Son efficacité a été comparé avec deux produits de référence : la Mn(III)-méso-tétra(4-sulfonatophenyl)porphyrine (Mn(III)TSPP), et Fe(II)-méso-tétra(N-methylpyridinium)porphyrine (Fe(II)TMPyP) à de deux champs magnétiques de 20 MHz et 60 MHz. En particulier, la relativité r1 la plus grande est obtenue pour le complexe Gd(TPyP) (24 mM-1s-1à 60 MHz) soit une effic

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Balasubramaniam, Sharavanan. "Synthesis, Characterization and Structure-Property Relationships of Polymer-Stabilized Nanoparticles Containing Imaging and Therapeutic Agents." Diss., Virginia Tech, 2014. http://hdl.handle.net/10919/55119.

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The controllable design of magnetic nanocarriers is essential for advanced in vivo applications such as magnetic resonance image-guided therapeutic delivery and alternating magnetic field-induced remote release of drugs. This work describes the fabrication of polymer-stabilized nanoparticles encapsulating imaging and therapeutic agents and delineates relationships among materials parameters and response. The effect of aggregation of magnetic iron oxide nanoparticles in aqueous suspension was characterized using a well-defined core-corona complex comprised of a superparamagnetic magnetite nanop

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Trevizan, Willian Andrighetto. "Nuclear magnetic resonance and digital rock in oil industry: well logging applications." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/76/76131/tde-10082017-113902/.

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This thesis discusses Nuclear Magnetic Resonance (NMR) techniques for formation evaluation in well log analysis for the oil/gas industry. We present the standard ingredients for NMR data processing and interpretation, and develop a methodology that extends the determination of surface relaxivity from the laboratory to the well site. The methodology consists of a processing algorithm for diffusion editing data, which enables surface relaxivity determination for conditions close to those found in well logging (regarding data availability and noise levels). At moderate noise levels, lower relaxiv

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Dia, Nada. "Nanoparticules photomagnétiques et agents de contraste à base de réseaux de coordination." Phd thesis, Université Paris Sud - Paris XI, 2013. http://tel.archives-ouvertes.fr/tel-00813757.

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L'état d'art concernant l'élaboration des matériaux inorganiques multifonctionnels, à l'échelle nanométrique, a fait l'objet de nombreuses recherches depuis vingt ans. Les réseaux de coordination tridimensionnels d'analogues de bleu de Prusse présentent des propriétés magnétiques modulables par l'application d'un stimulus extérieur (champ magnétique, irradiation lumineuse, pression ou variation de température etc...) qui mènent à une variété d'applications notamment pour le stockage de l'information et pour l'imagerie médicale. C'est dans ce cadre que s'inscrit ce travail de thèse.L'objectif p

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Shokouhimehr, Mohammadreza. "Prussian Blue Nanoparticles and its Analogues as New-Generation T1-Weighted MRI Contrast Agents for Cellular Imaging." Kent State University / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=kent1275612500.

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Kubíčková, Lenka. "Relaxivita magnetických nanočástic oxidů železa obsahujících diamagnetické kationty." Master's thesis, 2017. http://www.nusl.cz/ntk/nusl-355651.

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Magnetic nanoparticles have received extensive attention in the biomedical research, e.g. as prospective contrast agents for T2-weighted magnetic resonance imaging. The ability of a contrast agent to enhance the relaxation rate of 1 H in its vicinity is quantified by relaxivity. The main aim of this thesis is to evaluate the transversal re- laxivity of ε-Fe2−x Alx O3 nanoparticles coated with amorphous silica or citrate - its dependence on external magnetic field, temperature and thickness of silica coating - by means of nuclear magnetic resonance. The aluminium content x = 0.23(1) was determi

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Purser, Corrie N. "Protein Modification of Designed MRI Contrast Agents." 2015. http://scholarworks.gsu.edu/chemistry_theses/84.

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Protein based contrast agents (ProCAs) developed by the Yang lab exhibit unique capabilities in enabling magnetic resonance imaging (MRI) with significantly improved sensitivity and targeting capabilities by utilizing biomarkers which can target various carcinomas in animals. Further clinical in vivo human applications require modifications of these designed contrast agents to further improve organ and tissue biodistribution, biomarker and cell targeting capabilities, and reduction of immunogenicity. The aim of this thesis is to develop a novel protein modification on ProCA by glycosylation to

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Chen, Jie-min, and 陳傑閔. "The crowding effect of polyethylene glycol and bovine serum albumin on the relaxivity of magnetic resonance imaging contrast agents." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/44882650908951900611.

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Chaudhary, Richa. "Next Generation Lanthanide-based Contrast Agents for Applications in MRI, Multimodal Imaging, and Anti-cancer Therapies." Thesis, 2008. http://hdl.handle.net/1807/11135.

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A new class of polymer stabilized gadolinium trifluoride nanoparticles (NPs) have been developed as contrast agents for magnetic resonance imaging (MRI) and computed tomography (CT), with potential long term goals in targeted imaging and anti-cancer therapy. The NPs are comprised of a 90/10 mixture of GdF3/EuF3 and are coated with linear polyacrylic acid (PAA) chains consisting of 25 repeating units. The resulting aggregates are stable in serum and possess unprecedented mass relaxivities [i.e. ~100-200 s-1(mg/mL)-1]. Electron microscopy images reveal various NP morphologies which depend on

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Dömer, Henning [Verfasser]. "Vergleich zweier MRT-Kontrastmittel mit unterschiedlicher T1-Relaxivität zur Gefäßdarstellung bei Patienten mit abdominellen Aortenaneurysmen / vorgelegt von Henning Dömer." 2009. http://d-nb.info/998904333/34.

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Zemek, Ondřej. "Organofosforové deriváty pro "click-chemistry"." Master's thesis, 2013. http://www.nusl.cz/ntk/nusl-323512.

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Ondřej Zemek Organophosphorus derivatives for "click-chemistry" In this diploma thesis two new macrocyclic ligands were synthesized. They have DO3A moiety where metal (lanthanide) ion can be coordinated and terminal acetylenic or azide group connected through the phosphinic acid. Both terminal acetylenic and azide group should serve for connecting to another molecules or partitions by mean of "click chemistry" i.e. [1,3] copperI catalyzed dipolar cycloaddition between azide and acetylene. In this thesis two ligands, its complexes with some lanthanides as well as its precursors were prepared an

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Dash, Armita. "Nanoparticles as MRI contrast agents and biomarkers – applications in prostate cancer and mild traumatic brain injury." Thesis, 2017. https://dspace.library.uvic.ca//handle/1828/9009.

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Magnetic Resonance Imaging (MRI) is the most prominent non-invasive technique used in clinical diagnosis and biomedical research. Its development as an imaging technique has been aided by contrast agents (CAs) which enhance contrast to noise ratio in the images. This dissertation deals with paramagnetic lanthanide- and superparamagnetic iron-based nanoparticles (NPs) which are potential CAs at clinical field of 3 T and a high field of 9.4 T. Chapter 1 provides a brief overview of colloidal nanoparticles, with an emphasis on their surface chemistry and magnetic properties for bio-applications.

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Nagel, Sarah Mandy, Christoph Strangfeld, and Sabine Kruschwitz. "Determining the Pore Size Distribution in Synthetic and Building Materials Using 1D NMR." 2019. https://ul.qucosa.de/id/qucosa%3A37831.

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NMR is gaining increasing interest in civil engineering for applications regarding microstructure characterization as e.g., to determine pore sizes or to monitor moisture transport in porous materials. This study reveals the capability of NMR as a tool for pore size characterization. Therefore, we measured floor screed and synthetic materials at partial and full saturation. For most examined materials, the pore size distribution was successfully determined using either a reference or a calibration method. Since diffusion effects were observed for some samples in single-sided NMR measurements,

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