Log in

Relevant bibliographies by topics / Release orchestration / Journal articles

To see the other types of publications on this topic, follow the link: Release orchestration.

Journal articles on the topic 'Release orchestration'

Author: Grafiati

Published: 28 June 2021

Last updated: 29 July 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'Release orchestration.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Petrenko, Volodymyr, and Charna Dibner. "Circadian orchestration of insulin and glucagon release." Cell Cycle 16, no. 12 (2017): 1141–42. http://dx.doi.org/10.1080/15384101.2017.1326768.

Full text

APA, Harvard, Vancouver, ISO, and other styles

2

McCormick, Beth A., Charles A. Parkos, Sean P. Colgan, Denice K. Carnes, and James L. Madara. "Apical Secretion of a Pathogen-Elicited Epithelial Chemoattractant Activity in Response to Surface Colonization of Intestinal Epithelia by Salmonella typhimurium." Journal of Immunology 160, no. 1 (1998): 455–66. http://dx.doi.org/10.4049/jimmunol.160.1.455.

Full text

Abstract:

Abstract Modeling Salmonella-epithelial cell interaction in vitro has led to the realization that epithelial cells are crucial in orchestrating neutrophil (PMN) responses, in part by stimulating basolateral release of epithelial chemokines, including IL-8. However, such basolaterally released chemokines, while likely important in orchestration of PMN movement across the subepithelial matrix, are unlikely to be responsible for the final step of transepithelial migration of PMN and entry into the apical compartment. We now show that S. typhimurium attachment to T84 cell apical epithelial membran

APA, Harvard, Vancouver, ISO, and other styles

3

Minns, Danielle, Katie Jane Smith, and Emily Gwyer Findlay. "Orchestration of Adaptive T Cell Responses by Neutrophil Granule Contents." Mediators of Inflammation 2019 (March 10, 2019): 1–15. http://dx.doi.org/10.1155/2019/8968943.

Full text

Abstract:

Neutrophils are the most abundant leukocytes in peripheral blood and respond rapidly to danger, infiltrating tissues within minutes of infectious or sterile injury. Neutrophils were long thought of as simple killers, but now we recognise them as responsive cells able to adapt to inflammation and orchestrate subsequent events with some sophistication. Here, we discuss how these rapid responders release mediators which influence later adaptive T cell immunity through influences on DC priming and directly on the T cells themselves. We consider how the release of granule contents by neutrophils—th

APA, Harvard, Vancouver, ISO, and other styles

4

Karampini, Ellie, Ruben Bierings, and Jan Voorberg. "Orchestration of Primary Hemostasis by Platelet and Endothelial Lysosome-Related Organelles." Arteriosclerosis, Thrombosis, and Vascular Biology 40, no. 6 (2020): 1441–53. http://dx.doi.org/10.1161/atvbaha.120.314245.

Full text

Abstract:

Megakaryocyte-derived platelets and endothelial cells store their hemostatic cargo in α- and δ-granules and Weibel-Palade bodies, respectively. These storage granules belong to the lysosome-related organelles (LROs), a heterogeneous group of organelles that are rapidly released following agonist-induced triggering of intracellular signaling pathways. Following vascular injury, endothelial Weibel-Palade bodies release their content into the vascular lumen and promote the formation of long VWF (von Willebrand factor) strings that form an adhesive platform for platelets. Binding to VWF strings as

APA, Harvard, Vancouver, ISO, and other styles

5

Hariprasad, Sivaraman. "Intelligent Deployment Orchestration Using ML for Multi-Environment CI/CD Pipelines." INTERNATIONAL JOURNAL OF INNOVATIVE RESEARCH AND CREATIVE TECHNOLOGY 6, no. 4 (2020): 1–7. https://doi.org/10.5281/zenodo.14250622.

Full text

Abstract:

Continuous Integration (CI)/Continuous Development (CD) pipelines play an important role in stabilizing the release cycle of modern software development world. Though, deployments to multiple environments (dev, stg, prod) have their own set of problem statements. This work discusses a ML based deployment orchestration model to optimize multi-array CI/CD pipelines. Using predictive modeling and real-time decision-making, this orchestration system adaptively responds to different deployment conditions to achieve optimal resource utilization, risk-management, and minimized downtime. This paper pr

APA, Harvard, Vancouver, ISO, and other styles

6

Wang, Xiaogang, William J. Eagen, and Jean C. Lee. "Orchestration of human macrophage NLRP3 inflammasome activation by Staphylococcus aureus extracellular vesicles." Proceedings of the National Academy of Sciences 117, no. 6 (2020): 3174–84. http://dx.doi.org/10.1073/pnas.1915829117.

Full text

Abstract:

Release of extracellular vesicles (EVs) is a common feature among eukaryotes, archaea, and bacteria. However, the biogenesis and downstream biological effects of EVs released from gram-positive bacteria remain poorly characterized. Here, we report that EVs purified from a community-associated methicillin-resistant Staphylococcus aureus strain were internalized into human macrophages in vitro and that this process was blocked by inhibition of the dynamin-dependent endocytic pathway. Human macrophages responded to S. aureus EVs by TLR2 signaling and activation of NLRP3 inflammasomes through K+ e

APA, Harvard, Vancouver, ISO, and other styles

7

Venkata Krishna Koganti. "Autonomous CI/CD Meshes: Self-healing deployment architectures with AI-ML Orchestration." World Journal of Advanced Engineering Technology and Sciences 15, no. 2 (2025): 2731–45. https://doi.org/10.30574/wjaets.2025.15.2.0777.

Full text

Abstract:

This article introduces a novel architecture for autonomous continuous integration and continuous deployment (CI/CD) systems capable of self-healing and self-optimization without human intervention. The article presents intelligent deployment meshes that integrate deep anomaly detection using LSTM networks with Bayesian change-point detection to identify deployment anomalies before they impact production environments. The proposed framework leverages causal CI/CD graphs to model complex interdependencies between microservices, enabling context-aware remediation strategies including automated r

APA, Harvard, Vancouver, ISO, and other styles

8

Venkatesan Kannan. "Data Democratization in Pharmaceutical Laboratories: Transforming Insights into Action." Journal of Computer Science and Technology Studies 7, no. 6 (2025): 789–801. https://doi.org/10.32996/jcsts.2025.7.94.

Full text

Abstract:

Data democratization in pharmaceutical laboratories represents a transformative paradigm shift that enables broader access to scientific information across organizational boundaries in both research and development and quality control environments. The pharmaceutical industry faces significant challenges from historically siloed data ecosystems where specialized systems like Chromatography Data Systems, Laboratory Information Management Systems, and Electronic Lab Notebooks operate as isolated repositories across research laboratories and quality control testing laboratories. This fragmentatio

APA, Harvard, Vancouver, ISO, and other styles

9

Jagadeesh Thiruveedula, Hari Krishn Gupta, and Kumaresan Durvas Jayaraman. "Enhancing Real-Time Data Warehousing Through Intelligent ETL Pipeline Orchestration: A Comparative Study of Talend and IBM Data Stage." International Research Journal on Advanced Engineering Hub (IRJAEH) 3, no. 07 (2025): 3149–53. https://doi.org/10.47392/irjaeh.2025.0464.

Full text

Abstract:

In order to make active use of constantly gathered data, organizations now rely on real-time data warehousing. Faultless orchestration of ETL pipelines makes it possible for analytics platforms to consistently provide fast results and handle a lot of data which guarantees their reliability. This investigation evaluates Talend and IBM DataStage by simulating real-world streaming tasks that check for end-to-end latency, how much can be sustained, how much processing is required and how fault recovery functions. Data ingestion was found to increase greatly in Talend, despite requiring a moderate

APA, Harvard, Vancouver, ISO, and other styles

10

Almutairi, Jaber, and Mohammad Aldossary. "Modeling and Analyzing Offloading Strategies of IoT Applications over Edge Computing and Joint Clouds." Symmetry 13, no. 3 (2021): 402. http://dx.doi.org/10.3390/sym13030402.

Full text

Abstract:

Internet of Things (IoT) is swiftly evolving into a disruptive technology in recent years. For enhancing customer experience and accelerating job execution, IoT task offloading enables mobile end devices to release heavy computation and storage to the resource-rich nodes in collaborative Edges or Clouds. However, how different service architecture and offloading strategies quantitatively impact the end-to-end performance of IoT applications is still far from known particularly given a dynamic and unpredictable assortment of interconnected virtual and physical devices. This paper exploits poten

APA, Harvard, Vancouver, ISO, and other styles

11

Oliveira, Douglas Souza, Jean Gabriel de Souza, Miryam Paola Alvarez-Flores та ін. "Lonomia obliqua Venom Induces NF-κB Activation and a Pro-Inflammatory Profile in THP-1-Derived Macrophage". Toxins 13, № 7 (2021): 462. http://dx.doi.org/10.3390/toxins13070462.

Full text

Abstract:

Envenomation caused by contact with Lonomia obliqua bristles is characterized by pain, an intense systemic proinflammatory reaction and disturbances in the coagulation cascade that can cause severe clinical manifestations and death. However, the role of immune system components in these effects is still poorly understood. In this study, we evaluated the cytotoxic effect of L. obliqua venom on THP-1-derived macrophages and its ability to modulate inflammatory markers, as well as the cytokine and chemokine release profile. Our results show that L. obliqua venom is able to directly exert a potent

APA, Harvard, Vancouver, ISO, and other styles

12

Yu, Bin, Yizhe Tang, and Dongsheng Cai. "Brain is an endocrine organ through secretion and nuclear transfer of parathymosin." Life Science Alliance 3, no. 12 (2020): e202000917. http://dx.doi.org/10.26508/lsa.202000917.

Full text

Abstract:

This study reports that parathymosin (PTMS) is secreted by hypothalamic stem/progenitor cells (htNSC) to inhibit senescence of recipient cells such as fibroblasts. Upon release, PTMS is rapidly transferred into the nuclei of various cell types, including neuronal GT1-7 cells and different peripheral cells, and it is effectively transferred into neuronal nuclei in various brain regions in vivo. Notably, brain neurons also produce and release PTMS, and because neuronal populations are large, they are important for maintaining PTMS in the cerebrospinal fluid which is further transferable into the

APA, Harvard, Vancouver, ISO, and other styles

13

Shi, Jun-Zhuo, Xiao-Ming Zheng, Yun-Feng Zhou, et al. "Cornuside Is a Potential Agent against Alzheimer’s Disease via Orchestration of Reactive Astrocytes." Nutrients 14, no. 15 (2022): 3179. http://dx.doi.org/10.3390/nu14153179.

Full text

Abstract:

Cornuside is an iridoid glycoside from Cornus officinalis, with the activities of anti-inflammatory, antioxidant, anti-mitochondrial dysfunction, and neuroprotection. In the present research, a triple-transgenic mice model of AD (3 × Tg-AD) was used to explore the beneficial actions and potential mechanism of cornuside on the memory deficits. We found that cornuside prominently alleviated neuronal injuries, reduced amyloid plaque pathology, inhibited Tau phosphorylation, and repaired synaptic damage. Additionally, cornuside lowered the release of interleukin-1β (IL-1β), interleukin-6 (IL-6), t

APA, Harvard, Vancouver, ISO, and other styles

14

Sharma, Mayank, Maarten Litmaath, Eraldo Silva Junior, and Renato Santana. "Lightweight WLCG Sites." EPJ Web of Conferences 214 (2019): 07019. http://dx.doi.org/10.1051/epjconf/201921407019.

Full text

Abstract:

This article describes a new framework, called SIMPLE, for settingup and maintaining classic WLCG sites with minimal operational efforts and insights needed into the WLCG middleware. The framework provides a single common interface to install and configure any of its supported grid services, such as Compute Elements, Batch Systems, Worker Nodes and miscellaneous middleware packages. It leverages modern container orchestration tools like Kubernetes, Docker Swarm, and confiuration management tools like Puppet, Ansible, to automate deployment of the WLCG services on behalf of a site admin. The fr

APA, Harvard, Vancouver, ISO, and other styles

15

Kanthed, Surbhi. "Automation Tools for DevOps: Leveraging Ansible, Terraform, and Beyond." International Scientific Journal of Engineering and Management 04, no. 04 (2025): 1–7. https://doi.org/10.55041/isjem01286.

Full text

Abstract:

DevOps has rapidly become a cornerstone for modern software development, providing faster release cycles and improved collaboration between development and operations teams. Central to DevOps practices is automation, which addresses the complexity of provisioning and configuring diverse computing environments. This white paper explores state-of-the-art automation tools, with a focus on Ansible for configuration management and Terraform for infrastructure as code (IaC). An extensive review of recent scholarly articles, conference papers, and real-world case studies reveals the unique strengths

APA, Harvard, Vancouver, ISO, and other styles

16

Yan, Jing, Zohreh Hosseinzadeh, Bingbing Zhang, et al. "Decrease of Store-Operated Ca2+ Entry and Increase of Na+/Ca2+ Exchange by Pharmacological JAK2 Inhibition." Cellular Physiology and Biochemistry 38, no. 2 (2016): 683–95. http://dx.doi.org/10.1159/000443126.

Full text

Abstract:

Background/Aims: Cell proliferation and migration are regulated by cytosolic Ca2+ activity ([Ca2+]i). Mechanisms modifying [Ca2+]i include store-operated Ca2+-entry (SOCE) accomplished by the pore-forming ion channel unit Orai1 and its regulator STIM1, as well as Ca2+ extrusion by Na+/Ca2+ exchanger NCX1. Kinases participating in the orchestration of cell proliferation include the Janus activated kinase JAK2. The present study explored the impact of pharmacological JAK2 inhibition on SOCE and Na+/Ca2+ exchange. Methods: MCF-7 breast carcinoma cells were studied in the absence and presence of t

APA, Harvard, Vancouver, ISO, and other styles

17

Sackmann, Erich, and Motomu Tanaka. "Critical role of lipid membranes in polarization and migration of cells: a biophysical view." Biophysical Reviews 13, no. 1 (2021): 123–38. http://dx.doi.org/10.1007/s12551-021-00781-1.

Full text

Abstract:

AbstractCell migration plays vital roles in many biologically relevant processes such as tissue morphogenesis and cancer metastasis, and it has fascinated biophysicists over the past several decades. However, despite an increasing number of studies highlighting the orchestration of proteins involved in different signaling pathways, the functional roles of lipid membranes have been essentially overlooked. Lipid membranes are generally considered to be a functionless two-dimensional matrix of proteins, although many proteins regulating cell migration gain functions only after they are recruited

APA, Harvard, Vancouver, ISO, and other styles

18

Ozga, Aleksandra J., Federica Moalli, Jun Abe, et al. "pMHC affinity controls duration of CD8+ T cell–DC interactions and imprints timing of effector differentiation versus expansion." Journal of Experimental Medicine 213, no. 12 (2016): 2811–29. http://dx.doi.org/10.1084/jem.20160206.

Full text

Abstract:

During adaptive immune responses, CD8+ T cells with low TCR affinities are released early into the circulation before high-affinity clones become dominant at later time points. How functional avidity maturation is orchestrated in lymphoid tissue and how low-affinity cells contribute to host protection remains unclear. In this study, we used intravital imaging of reactive lymph nodes (LNs) to show that T cells rapidly attached to dendritic cells irrespective of TCR affinity, whereas one day later, the duration of these stable interactions ceased progressively with lowering peptide major histoco

APA, Harvard, Vancouver, ISO, and other styles

19

Bachert, Claus, Marc Humbert, Nicola A. Hanania, et al. "Staphylococcus aureus and its IgE-inducing enterotoxins in asthma: current knowledge." European Respiratory Journal 55, no. 4 (2020): 1901592. http://dx.doi.org/10.1183/13993003.01592-2019.

Full text

Abstract:

While immunoglobulin (Ig) E is a prominent biomarker for early-onset, its levels are often elevated in non-allergic late-onset asthma. However, the pattern of IgE expression in the latter is mostly polyclonal, with specific IgEs low or below detection level albeit with an increased total IgE. In late-onset severe asthma patients, specific IgE to Staphylococcal enterotoxins (se-IgE) can frequently be detected in serum, and has been associated with asthma, with severe asthma defined by hospitalisations, oral steroid use and decrease in lung function. Recently, se-IgE was demonstrated to even pre

APA, Harvard, Vancouver, ISO, and other styles

20

Chensue, S. W., P. D. Terebuh, K. S. Warmington, et al. "Role of IL-4 and IFN-gamma in Schistosoma mansoni egg-induced hypersensitivity granuloma formation. Orchestration, relative contribution, and relationship to macrophage function." Journal of Immunology 148, no. 3 (1992): 900–906. http://dx.doi.org/10.4049/jimmunol.148.3.900.

Full text

Abstract:

Abstract A well defined model of T cell-mediated hypersensitivity-type granulomatous inflammation induced by Schistosoma mansoni eggs was used to assess the role of IL-4 and IFN-gamma in granuloma development. Synchronized pulmonary granulomas were induced and isolated from S. mansoni-infected mice during vigorous (8 wk) and modulated (20 wk) stages of the disease. The sequential production of IL-4 and IFN was determined and related to temporal changes in granuloma macrophage production of IL-1, TNF, and superoxide anion (O2-). During the vigorous stage, IL-4 was produced on days 1 and 2 of gr

APA, Harvard, Vancouver, ISO, and other styles

21

Journal, of Global Research in Multidisciplinary Studies(JGRMS). "Serverless Computing and Cloud-Native Applications Trends in AWS, Kubernetes, and DevOps." Journal of Global Research in Multidisciplinary Studies(JGRMS) 01, no. 03 (2025): 01–07. https://doi.org/10.5281/zenodo.15245283.

Full text

Abstract:

Software development evolution lately resulted in extensive use of cloud-native with serverless computing structures which changed the way applications get designed for deployment. This paper delivers an extensive evaluation of latest developments in cloud-native and serverless models that focuses especially on DevOps methodology integration. Cloud-native architectures with their features of containerization and microservices and orchestration bring agility and scalability alongside fault tolerance capacity. Through serverless computing, developers gain complete infrastructure abstraction to r

APA, Harvard, Vancouver, ISO, and other styles

22

Yiu, Lik Man Daphne, and Ka Yui Karl Wu. "The Interactions of Absorptive Capacity, Buffer Inventory, and Toxic Emissions on Firm Value." International Journal of Environmental Research and Public Health 18, no. 4 (2021): 1979. http://dx.doi.org/10.3390/ijerph18041979.

Full text

Abstract:

A significant amount of research has been conducted on the impacts of emissions reduction, absorptive capacity, and buffer inventory on firm performance. According to the resource-based view (RBV), absorptive capacity and buffer inventory are organizational capabilities and resources to create sustainable competitive advantages. Yet, the resource orchestration perspective (ROP) of the RBV emphasizes that firms need to develop a new capability to orchestrate and deploy their existing capabilities and resources. From an organizational learning perspective, firms with the low-level release of tox

APA, Harvard, Vancouver, ISO, and other styles

23

Liu, Guilai, Guoxing Liu, Hong Chen, et al. "Rapid Upregulation of Orai1 Abundance in the Plasma Membrane of Platelets Following Activation with Thrombin and Collagen Related Peptide." Cellular Physiology and Biochemistry 37, no. 5 (2015): 1759–66. http://dx.doi.org/10.1159/000438539.

Full text

Abstract:

Background: Blood platelets accomplish primary hemostasis following vascular injury and contribute to the orchestration of occlusive vascular disease. Platelets are activated by an increase of cytosolic Ca2+-activity ([Ca2+]i), which is accomplished by Ca2+-release from intracellular stores and subsequent store operated Ca2+ entry (SOCE) through Ca2+ release activated Ca2+ channel moiety Orai1. Powerful activators of platelets include thrombin and collagen related peptide (CRP), which are in part effective by activation of small G- protein Rac1. The present study explored the influence of thro

APA, Harvard, Vancouver, ISO, and other styles

24

Shumilina, Ekaterina, Stephan M. Huber, and Florian Lang. "Ca2+signaling in the regulation of dendritic cell functions." American Journal of Physiology-Cell Physiology 300, no. 6 (2011): C1205—C1214. http://dx.doi.org/10.1152/ajpcell.00039.2011.

Full text

Abstract:

Dendritic cells (DCs) are highly versatile antigen-presenting cells critically involved in both innate and adaptive immunity as well as maintenance of self-tolerance. DC function is governed by Ca2+signaling, which directs the DC responses to diverse antigens, including Toll-like receptor ligands, intact bacteria, and microbial toxins. Ca2+-sensitive DC functions include DC activation, maturation, migration, and formation of immunological synapses with T cells. Moreover, alterations of cytosolic Ca2+trigger immune suppression or switch off DC activity. Ca2+signals are generated by the orchestr

APA, Harvard, Vancouver, ISO, and other styles

25

Parag, Bhardwaj. "Driving Operational Efficiency through Azure Automation and PowerShell." International Journal on Science and Technology 12, no. 3 (2021): 1–9. https://doi.org/10.5281/zenodo.14613902.

Full text

Abstract:

In modern times, operational efficiency in enterprises can only be driven by automating workflows, decreasing manual errors and optimizing resource allocation. With PowerShell and Azure Automation, you have a powerful approach to automate repetitive work, maintain your cloud resources, and manage consistent scenarios across environments. Organizations can use the functionality offered by Azure Automation to automate processes like patch management, backup scheduling, virtual machine scaling, and resource provisioning, minimizing the burden of administration for an IT team. This is enhanced by

APA, Harvard, Vancouver, ISO, and other styles

26

Hanna-Mitchell, Ann T., Amanda Wolf-Johnston, James R. Roppolo, Tony C. A. Buffington, and Lori A. Birder. "Corticotropin-releasing factor family peptide signaling in feline bladder urothelial cells." Journal of Endocrinology 222, no. 1 (2014): 113–21. http://dx.doi.org/10.1530/joe-13-0422.

Full text

Abstract:

Corticotropin-releasing factor (CRF) plays a central role in the orchestration of behavioral and neuroendocrine responses to stress. The family of CRF-related peptides (CRF and paralogs: urocortin (Ucn)-I, -II, and -III) and associated receptors (CRFR1 and CRFR2) are also expressed in peripheral tissues such as the skin and gastrointestinal tract. Local signaling may exert multiple effects of stress-induced exacerbation of many complex syndromes, including psoriasis and visceral hypersensitivity. Interstitial cystitis/painful bladder syndrome (IC/PBS), a chronic visceral pain syndrome characte

APA, Harvard, Vancouver, ISO, and other styles

27

Yan, Jing, Bingbing Zhang, Zohreh Hosseinzadeh, and Florian Lang. "Down-Regulation of Store-Operated Ca2+ Entry and Na+ Ca2+ Exchange in MCF-7 Breast Cancer Cells by Pharmacological JAK3 Inhibition." Cellular Physiology and Biochemistry 38, no. 4 (2016): 1643–51. http://dx.doi.org/10.1159/000443104.

Full text

Abstract:

Background/Aims: Oscillations of cytosolic Ca2+ activity ([Ca2+]i) participate in the orchestration of tumor cell proliferation. [Ca2+]i could be increased by intracellular Ca2+ release followed by store-operated Ca2+-entry (SOCE). [Ca2+]i could be decreased by Ca2+ extrusion via Na+/Ca2+ exchange. Mechanisms accomplishing SOCE include the pore-forming ion channel unit Orai1 and its regulator STIM1, Na+/Ca2+ exchanger isoforms include NCX1. In MCF-7 breast carcinoma cells Orai1 and NCX1 have previously been shown to be modified by pharmacological inhibition of Janus activated kinase JAK2. The

APA, Harvard, Vancouver, ISO, and other styles

28

Sumeet, Baburao Patond, Ramnath Satpute Shubham, and Sidramappa Patil |. Aishwarya Shivkumar Kapase |. Prof.D.D.Sapkal Smita. "Microservice Oriented Application Development." International Journal of Trend in Scientific Research and Development 2, no. 4 (2018): 1130–35. https://doi.org/10.31142/ijtsrd14318.

Full text

Abstract:

About a decade ago developers used to follow monolithic approach for developing application. There used to be a single large application containing millions of lines of code. And it would take hours just to build an application. Many people used to work together to build an application. If bug was found in any single line of code then we had to take down application. So other peoples work too couldnt get out. So this would delay the release of an application. Now a days the concept of microservices came into picture. In this approach we divide single large monolithic application into multiple

APA, Harvard, Vancouver, ISO, and other styles

29

Schellenbauer, Amelie, Marie-Noelle Guilly, Romain Grall, et al. "Phospho-Ku70 induced by DNA damage interacts with RNA Pol II and promotes the formation of phospho-53BP1 foci to ensure optimal cNHEJ." Nucleic Acids Research 49, no. 20 (2021): 11728–45. http://dx.doi.org/10.1093/nar/gkab980.

Full text

Abstract:

Abstract Canonical non-homologous end-joining (cNHEJ) is the prominent mammalian DNA double-strand breaks (DSBs) repair pathway operative throughout the cell cycle. Phosphorylation of Ku70 at ser27-ser33 (pKu70) is induced by DNA DSBs and has been shown to regulate cNHEJ activity, but the underlying mechanism remained unknown. Here, we established that following DNA damage induction, Ku70 moves from nucleoli to the sites of damage, and once linked to DNA, it is phosphorylated. Notably, the novel emanating functions of pKu70 are evidenced through the recruitment of RNA Pol II and concomitant fo

APA, Harvard, Vancouver, ISO, and other styles

30

Florman, Jeremy T., and Mark J. Alkema. "Co-transmission of neuropeptides and monoamines choreograph the C. elegans escape response." PLOS Genetics 18, no. 3 (2022): e1010091. http://dx.doi.org/10.1371/journal.pgen.1010091.

Full text

Abstract:

Co-localization and co-transmission of neurotransmitters and neuropeptides is a core property of neural signaling across species. While co-transmission can increase the flexibility of cellular communication, understanding the functional impact on neural dynamics and behavior remains a major challenge. Here we examine the role of neuropeptide/monoamine co-transmission in the orchestration of the C. elegans escape response. The tyraminergic RIM neurons, which coordinate distinct motor programs of the escape response, also co-express the neuropeptide encoding gene flp-18. We find that in response

APA, Harvard, Vancouver, ISO, and other styles

31

Stojanovic, Bojana S., Bojan Stojanovic, Jelena Milovanovic, et al. "The Pivotal Role of Galectin-3 in Viral Infection: A Multifaceted Player in Host–Pathogen Interactions." International Journal of Molecular Sciences 24, no. 11 (2023): 9617. http://dx.doi.org/10.3390/ijms24119617.

Full text

Abstract:

Galectin-3 (Gal-3), a beta-galactoside-binding lectin, plays a pivotal role in various cellular processes, including immune responses, inflammation, and cancer progression. This comprehensive review aims to elucidate the multifaceted functions of Gal-3, starting with its crucial involvement in viral entry through facilitating viral attachment and catalyzing internalization. Furthermore, Gal-3 assumes significant roles in modulating immune responses, encompassing the activation and recruitment of immune cells, regulation of immune signaling pathways, and orchestration of cellular processes such

APA, Harvard, Vancouver, ISO, and other styles

32

Shyu, Yu-Chiau, Ting-Shuo Huang, Hua-Sheng Chiu, et al. "Deciphering Early-Stage Molecular Mechanisms of Negative Pressure Wound Therapy in a Murine Model." International Journal of Molecular Sciences 25, no. 4 (2024): 2373. http://dx.doi.org/10.3390/ijms25042373.

Full text

Abstract:

Negative Pressure Wound Therapy (NPWT) is a commonly employed clinical strategy for wound healing, yet its early-stage mechanisms remain poorly understood. To address this knowledge gap and overcome the limitations of human trials, we establish an NPWT C57BL/6JNarl mouse model to investigate the molecular mechanisms involved in NPWT. In this study, we investigate the intricate molecular mechanisms through which NPWT expedites wound healing. Our focus is on NPWT’s modulation of inflammatory immune responses and the concurrent orchestration of multiple signal transduction pathways, resulting in

APA, Harvard, Vancouver, ISO, and other styles

33

Anatolii, Husakovskyi. "Enhancing Automation in QA Engineering with Advanced AI Techniques in Complex Distributed Systems." Asian Journal of Research in Computer Science 18, no. 4 (2025): 410–15. https://doi.org/10.9734/ajrcos/2025/v18i4628.

Full text

Abstract:

Aims: This study explores integrating artificial intelligence (AI) into automated quality assurance (QA) workflows for complex distributed systems. Study Design: A multi-phase empirical approach was adopted. First, I developed a novel AI-driven test framework. Next, I deployed it in a real-world microservices environment and compared key metrics (defect detection rates, test coverage, execution time) against a conventional, manually-maintained QA suite. Place and Duration of Study: This work was conducted at the Department of Computer Science and Engineering, «Kharkiv Aviation Institute», from

APA, Harvard, Vancouver, ISO, and other styles

34

Sokratis Barmpounakis, Nancy Alonistioti, George C. Alexandropoulos, and Alexandros Kaloxylos. "Dynamic infrastructure-as-a-service: A key paradigm for 6G networks and application to maritime communications." ITU Journal on Future and Evolving Technologies 3, no. 1 (2022): 55–70. http://dx.doi.org/10.52953/wqwx1975.

Full text

Abstract:

Although, the advent of the fifth Generation (5G) of communication networks has introduced the technology enablers and system capability to support a large number of devices, and highly-demanding services, as well as ultra-low latency and high reliability, enhancements to the current systems will not suffice for future generation networks. Instead, a disruptive communication paradigm needs to be introduced that will ultimately enable the radical evolution of the current systems to a new ones, capable of self-aggregating extraordinary connectivity and computing capabilities in a seamless manner

APA, Harvard, Vancouver, ISO, and other styles

35

Lawrence, Donald W., Walter J. Bruyninckx, Nancy A. Louis, et al. "Antiadhesive Role of Apical Decay-accelerating Factor (CD55) in Human Neutrophil Transmigration across Mucosal Epithelia." Journal of Experimental Medicine 198, no. 7 (2003): 999–1010. http://dx.doi.org/10.1084/jem.20030380.

Full text

Abstract:

Neutrophil migration across mucosal epithelium during inflammatory episodes involves the precise orchestration of a number a cell surface molecules and signaling pathways. After successful migration to the apical epithelial surface, apically localized epithelial proteins may serve to retain PMN at the lumenal surface. At present, identification of apical epithelial ligands and their PMN counter-receptors remain elusive. Therefore, to define the existence of apical epithelial cell surface proteins involved in PMN–epithelial interactions, we screened a panel of antibodies directed against epithe

APA, Harvard, Vancouver, ISO, and other styles

36

Jacques, Camille, Flora Marchand, Mathias Chatelais, Adrien Brulefert, Mathieu Riffault, and Ilaria Floris. "In Vitro Study of Interleukin-6 when Used at Low Dose and Ultra-Low Dose in Micro-Immunotherapy." Life 14, no. 3 (2024): 375. http://dx.doi.org/10.3390/life14030375.

Full text

Abstract:

As one of the major cytokines implicated in the orchestration of immune responses, interleukin 6 (IL-6) can either act as a pro- or an anti-inflammatory factor, depending on the micro-environment. In micro-immunotherapy (MI) medicines, IL-6 is employed at low doses (LD) and ultra-low doses (ULD), expressed in centesimal Hahnemannian (CH), and used alone or in combination with other immune regulators to modulate patients’ immune responses. The present study focused on assessing the in vitro immune-modulatory effects of two IL-6-containing MI products: (i) the unitary IL-6 (4 CH) and (ii) the co

APA, Harvard, Vancouver, ISO, and other styles

37

Eichhorn, Lars, Jan Lukas Kleiner, Benedikt Bartsch, et al. "CCR2 dependent recruited pro-inflammatory monocytes contribute to the development of left ventricular hypertrophy in mice upon transverse aortic constriction." PLOS ONE 20, no. 4 (2025): e0318407. https://doi.org/10.1371/journal.pone.0318407.

Full text

Abstract:

C-C chemokine receptor type 2 positive monocytes are recruited from the circulation to infiltrate inflamed tissue. Left ventricular (LV) hypertrophy caused by pressure overload presents with a chronic myocardial inflammation in our mouse model of transverse aortic constriction (TAC). Recent analyses demonstrated that deficiency of fractalkine receptor CX3CR1 leads to a pro-inflammatory phenotype characterized by increased numbers of Ly6Chigh macrophages in the myocardium due to chemokine receptor CCR2 dependent monocyte recruitment from the circulation. Here, we analyzed the role of CCR2 in th

APA, Harvard, Vancouver, ISO, and other styles

38

Decker, Jonathan, Vincent Florens Hasse, and Julian Kunkel. "Q8S: Emulation of Heterogeneous Kubernetes Clusters Using QEMU." Algorithms 18, no. 6 (2025): 324. https://doi.org/10.3390/a18060324.

Full text

Abstract:

Kubernetes has emerged as the industry standard for container orchestration in cloud environments, with its scheduler dynamically placing container instances across cluster nodes based on predefined rules and algorithms. Various efforts have been made to extend and improve upon the Kubernetes scheduler. However, as the majority of Kubernetes clusters operate on homogeneous hardware, most scheduling algorithms are also only developed for homogeneous systems. Heterogeneous infrastructures, which include IoT devices or specialized hardware, have become more widespread and require specialized tuni

APA, Harvard, Vancouver, ISO, and other styles

39

Rice, Phoebe A., Kent W. Mouw, Sherwin P. Montaño, Martin R. Boocock, Sally-J. Rowland, and W. Marshall Stark. "Orchestrating serine resolvases." Biochemical Society Transactions 38, no. 2 (2010): 384–87. http://dx.doi.org/10.1042/bst0380384.

Full text

Abstract:

A remarkable feature of the serine resolvases is their regulation: the wild-type enzymes will catalyse intra- but not inter-molecular recombination, can sense the relative orientation of their sites and can exchange strands directionally, despite the fact that there is no net release of chemical bond energy. The key to this regulation is that they are only active within a large intertwined complex called the ‘synaptosome’. Because substrate topology greatly facilitates (or, in other cases, inhibits) formation of the synaptosome, it acts as a ‘topological filter’. Within the defined topology of

APA, Harvard, Vancouver, ISO, and other styles

40

Babamale, Abdulkareem Olarewaju, and Szu-Ting Chen. "Nod-like Receptors: Critical Intracellular Sensors for Host Protection and Cell Death in Microbial and Parasitic Infections." International Journal of Molecular Sciences 22, no. 21 (2021): 11398. http://dx.doi.org/10.3390/ijms222111398.

Full text

Abstract:

Cell death is an essential immunological apparatus of host defense, but dysregulation of mutually inclusive cell deaths poses severe threats during microbial and parasitic infections leading to deleterious consequences in the pathological progression of infectious diseases. Nucleotide-binding oligomerization domain (NOD)-Leucine-rich repeats (LRR)-containing receptors (NLRs), also called nucleotide-binding oligomerization (NOD)-like receptors (NLRs), are major cytosolic pattern recognition receptors (PRRs), their involvement in the orchestration of innate immunity and host defense against bact

APA, Harvard, Vancouver, ISO, and other styles

41

Irigoín, Florencia, Natalia M. Inada, Mariana P. Fernandes, et al. "Mitochondrial calcium overload triggers complement-dependent superoxide-mediated programmed cell death in Trypanosoma cruzi." Biochemical Journal 418, no. 3 (2009): 595–604. http://dx.doi.org/10.1042/bj20081981.

Full text

Abstract:

The epimastigote stage of Trypanosoma cruzi undergoes PCD (programmed cell death) when exposed to FHS (fresh human serum). Although it has been known for over 30 years that complement is responsible for FHS-induced death, the link between complement activation and triggering of PCD has not been established. We have previously shown that the mitochondrion participates in the orchestration of PCD in this model. Several changes in mitochondrial function were described, and in particular it was shown that mitochondrion-derived O2•− (superoxide radical) is necessary for PCD. In the present study, w

APA, Harvard, Vancouver, ISO, and other styles

42

Cleveland, Simon, and Timothy J. Ellis. "Orchestrating End-User Perspectives in the Software Release Process: An Integrated Release Management Framework." Advances in Human-Computer Interaction 2014 (2014): 1–15. http://dx.doi.org/10.1155/2014/805307.

Full text

Abstract:

Software bugs discovered by end-users are inevitable consequences of a vendor’s lack of testing. While they frequently result in costly system failures, one way to detect and prevent them is to engage the customer in acceptance testing during the release process. Yet, there is a considerable lack of empirical studies examining release management from end-users’ perspective. To address this gap, we propose and empirically test a release framework that positions the customer release manager in the center of the release process. Using a participatory action research strategy, a twenty-seven-month

APA, Harvard, Vancouver, ISO, and other styles

43

Brown, C. H., V. Scott, M. Ludwig, G. Leng, and C. W. Bourque. "Somatodendritic dynorphin release: orchestrating activity patterns of vasopressin neurons." Biochemical Society Transactions 35, no. 5 (2007): 1236–42. http://dx.doi.org/10.1042/bst0351236.

Full text

Abstract:

Most neurons in the central nervous system co-express peptides alongside their principal transmitter, yet the function of these peptides is largely unknown. Vasopressin neurons of the hypothalamic supraoptic nucleus and paraventricular nucleus contain among the highest concentrations of dynorphin found in the brain. Dynorphin, an endogenous opioid peptide, is co-localized in the same neurosecretory vesicles as vasopressin and is released alongside vasopressin from the dendrites and axon terminals of vasopressin neurons. We and others have shown that neuropeptide release from the soma and dendr

APA, Harvard, Vancouver, ISO, and other styles

44

Carpentier, Grégoire, Eric Daubresse, Marc Garcia Vitoria, Kenji Sakai, and Fernando Villanueva. "Automatic Orchestration in Practice." Computer Music Journal 36, no. 3 (2012): 24–42. http://dx.doi.org/10.1162/comj_a_00136.

Full text

Abstract:

We report here on the recent use of the Orchidée software by three different young composers in various compositional and instrumental contexts. Orchidée is a computer-aided orchestration environment designed to aid musicians exploring the space of instrument timbre mixtures and finding timbre combinations that fit a set of user-specified perceptual requirements. The first beta version of the software was released by the Institut de Recherche et Coordination Acoustique/Musique's (IRCAM's) Music Representations Group in 2009, after four years of intensive research, and it can already handle a s

APA, Harvard, Vancouver, ISO, and other styles

45

Alberdi-Páramo, Í., M. Pérez-Lombardo, J. Pemán-Rodríguez, et al. "Euthanasia - A Novel Intricacy for Psychiatry’s Purview?" European Psychiatry 67, S1 (2024): S332. http://dx.doi.org/10.1192/j.eurpsy.2024.687.

Full text

Abstract:

IntroductionNumerous countries, notably within Europe, have sanctioned the practice of euthanasia. Extant legal frameworks meticulously define the extent, essence, and application of euthanasia, encompassing divergent characterizations, explications of entitlements, procedural modalities, and provisions for access. Nonetheless, the precise function of psychiatrists within these legislative contours remains conspicuously nebulous.ObjectivesThe present inquiry undertakes a comprehensive evaluative review of the euthanasia phenomenon vis-à-vis the intricate tapestry of European legislative paradi

APA, Harvard, Vancouver, ISO, and other styles

46

Golian, Nataliia, and Varvara Tisheninova. "INTEGRATED GRAPH-BASED TESTING PIPELINE FOR MODERN SINGLE-PAGE APPLICATIONS." Bulletin of National Technical University "KhPI". Series: System Analysis, Control and Information Technologies, no. 1 (13) (July 11, 2025): 51–59. https://doi.org/10.20998/2079-0023.2025.01.08.

Full text

Abstract:

In the modern software development ecosystem, Single-Page Applications (SPAs) have become the de facto standard for delivering rich, interactive user experiences. Frameworks such as React, Vue, and Angular enable developers to build highly responsive interfaces; however, they also introduce intricate client-side state management and complex routing logic. As applications grow in size and complexity, manually writing and maintaining end-to-end tests for every possible user journey becomes infeasible. Moreover, ensuring comprehensive coverage − across functionality, security, performance, and us

APA, Harvard, Vancouver, ISO, and other styles

47

Researcher. "ORCHESTRATING THE CLOUD: AI-ENHANCED RELEASE AUTOMATION IN KUBERNETES ENVIRONMENTS." International Journal of Research In Computer Applications and Information Technology (IJRCAIT) 7, no. 2 (2024): 864–78. https://doi.org/10.5281/zenodo.14045753.

Full text

Abstract:

Cloud-native architectures have revolutionized software deployment, necessitating advanced release automation strategies to manage increasingly complex environments. This article explores the synergy between Kubernetes and artificial intelligence in facilitating scalable, self-healing, and optimized deployments for cloud-native applications. We present a comprehensive framework for implementing automated deployment pipelines within Kubernetes clusters, leveraging its native features for horizontal scaling and rolling updates. The integration of AI-driven tools for predictive scaling, anomaly d

APA, Harvard, Vancouver, ISO, and other styles

48

Kwon, Somin, Alexandra Beilina, Nathan Smith, et al. "LRRK2-mediated microglial activation via NFATc2: a novel mechanism of neurotoxic inflammation in synucleinopathies." Journal of Immunology 204, no. 1_Supplement (2020): 64.7. http://dx.doi.org/10.4049/jimmunol.204.supp.64.7.

Full text

Abstract:

Abstract Neuroinflammation is a key pathological feature of a set of neurological disorders called synucleinopathies, which are characterized by abnormal a-synuclein (a-syn) dynamics and include Parkinson’s disease (PD), dementia with Lewy Bodies (DLB), and multiple system atrophy (MSA). Microglia, the resident macrophages of the central nervous system, are critical for orchestrating the inflammatory response in these diseases. In particular, microglia can directly bind neuron-released a-syn via receptors such as Toll-like receptor 2 (TLR2) to adopt a reactive phenotype. Here we explored the p

APA, Harvard, Vancouver, ISO, and other styles

49

Liu, Jinchun, Zhaoxia Li, Yang Yu, and Minghui Liu. "Research on Computing Power Network Service Orchestration and Schedulin." Advances in Engineering Technology Research 13, no. 1 (2025): 358. https://doi.org/10.56028/aetr.13.1.358.2025.

Full text

Abstract:

The computing power network service orchestration and scheduling method is studied, and the computing network perception based on the computing power network is proposed in the Internet of Vehicles scenario, and then the computing is carried out according to the perception information. At the same time, in the process of orchestration and scheduling, the pre-preparation of the computing power service in the cloud is carried out according to the route of the terminal, so as to achieve the effect of rapid switching of the computing power service node and the user's imperceptibility. Finally, the

APA, Harvard, Vancouver, ISO, and other styles

50

Kirkpatrick, Riley, Joanne Beer, Manishkumar S. Patel, et al. "Abstract 3867: Identification of novel biomarkers of immune toxicity from CAR T-cell therapy using ultrasensitive NULISA™ proteome technology." Cancer Research 84, no. 6_Supplement (2024): 3867. http://dx.doi.org/10.1158/1538-7445.am2024-3867.

Full text

Abstract:

Abstract Introduction: The efficacy of anti-CD19 chimeric antigen receptor (CAR) T-cell therapy in patients with relapsed/refractory large B-cell lymphoma (LBCL) is limited by acute toxic events, most notably cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS). Identification of biomarkers of toxicities can allow for selection of high-risk patients and elucidate targetable mechanisms for mitigation. Previous biomarker studies have been constrained by relatively narrow panels of potential mediators and limited time points. Here, we employed NULISA,

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!