Academic literature on the topic 'Remodelled genes'

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Journal articles on the topic "Remodelled genes"

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Germain, Adeline, Jeanne-Marie Perotin, Gonzague Delepine, Myriam Polette, Gaëtan Deslée, and Valérian Dormoy. "Whole-Exome Sequencing of Bronchial Epithelial Cells Reveals a Genetic Print of Airway Remodelling in COPD." Biomedicines 10, no. 7 (2022): 1714. http://dx.doi.org/10.3390/biomedicines10071714.

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The remodelling of the airways is a hallmark of chronic obstructive pulmonary disease, but it is highly heterogeneous and erratically distributed in the airways. To assess the genetic print of remodelling in chronic obstructive pulmonary disease (COPD), we performed a comparative whole-exome sequencing analysis on microdissected bronchial epithelia. Lung resections from four non-COPD and three COPD subjects (ex-smokers and current smokers) were formalin-fixed paraffin-embedded (FFPE). Non-remodelled and remodelled bronchial epithelia were isolated by laser microdissection. Genomic DNA was capt
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Li, Mengyao, Su Mon Aye, Maizbha Uddin Ahmed, et al. "Pan-transcriptomic analysis identified common differentially expressed genes of Acinetobacter baumannii in response to polymyxin treatments." Molecular Omics 16, no. 4 (2020): 327–38. http://dx.doi.org/10.1039/d0mo00015a.

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Our pan-transcriptomic study for polymyxin-treated A. baumannii identified that the remodelled outer membrane, up-regulated efflux pumps and down-regulated fatty acid biosynthesis might be essential for early responses to polymyxins in A. baumannii.
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Ou, Yaqing, and James O. McInerney. "Eukaryote Genes Are More Likely than Prokaryote Genes to Be Composites." Genes 10, no. 9 (2019): 648. http://dx.doi.org/10.3390/genes10090648.

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The formation of new genes by combining parts of existing genes is an important evolutionary process. Remodelled genes, which we call composites, have been investigated in many species, however, their distribution across all of life is still unknown. We set out to examine the extent to which genomes from cells and mobile genetic elements contain composite genes. We identify composite genes as those that show partial homology to at least two unrelated component genes. In order to identify composite and component genes, we constructed sequence similarity networks (SSNs) of more than one million
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Kuleesha, Yadav, Wee Choo Puah, and Martin Wasser. "A model of muscle atrophy based on live microscopy of muscle remodelling in Drosophila metamorphosis." Royal Society Open Science 3, no. 2 (2016): 150517. http://dx.doi.org/10.1098/rsos.150517.

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Genes controlling muscle size and survival play important roles in muscle wasting diseases. In Drosophila melanogaster metamorphosis, larval abdominal muscles undergo two developmental fates. While a doomed population is eliminated by cell death, another persistent group is remodelled and survives into adulthood. To identify and characterize genes involved in the development of remodelled muscles, we devised a workflow consisting of in vivo imaging, targeted gene perturbation and quantitative image analysis. We show that inhibition of TOR signalling and activation of autophagy promote developm
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Wang, Yuzhe, Shiyu Li, Mengge Liu, et al. "Rhodosporidium toruloides sir2-like genes remodelled the mitochondrial network to improve the phenotypes of ageing cells." Free Radical Biology and Medicine 134 (April 2019): 64–75. http://dx.doi.org/10.1016/j.freeradbiomed.2018.12.036.

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Ahmedien, Diaa Ahmed Mohamed. "Bio-pixels: A stem cell-based interactive–generative interface designed to redefine technologies of self-making in new media arts." Convergence: The International Journal of Research into New Media Technologies 26, no. 5-6 (2019): 1367–90. http://dx.doi.org/10.1177/1354856519890096.

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Bio-pixels is a stem cell-based interactive–generative interface designed to investigate the concept of ‘self-making’. The project uses stem cells as a biological prototype of an identity-free substance and defines in vivo stem cell differentiation processes as nature’s self-making technology. It therefore considers in vitro-induced differentiation processes as artificial self-making technologies that were recontextualized through the interactions between the world of genes and the world of bits. The project’s system was functionally built based on three operational principles derived from con
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Vora, Hemangini Hasit. "Identification of Extra Cellular Matrix (ECM) Genes in Triple Negative Breast Cancer." Asian Pacific Journal of Cancer Biology 10, no. 2 (2025): 301–7. https://doi.org/10.31557/apjcb.2025.10.2.301-307.

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Introduction: Extracellular Matrix (ECM) is often abnormally produced, degraded, and remodelled, which creates a pro-tumorigenic environment in cancer and leads to tumor growth, angiogenesis, invasion and metastasis. This study aimed to investigate ECM genes by microarray-based transcriptome analysis and miRNA that target ECM genes in triple-negative breast cancer (TNBC). Materials and Methods: The current study evaluated 682 TME-related genes using Array Comparative Genomic Hybridization (aCGH) in 55 patients with TNBC. Results: 266 ECM genes were studied by transcriptome analysis, and it was
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Dalla Torre, Marco, Daniele Pittari, Alessandra Boletta, Laura Cassina, Roberto Sitia, and Tiziana Anelli. "Mitochondria remodeling during endometrial stromal cell decidualization." Life Science Alliance 7, no. 12 (2024): e202402627. http://dx.doi.org/10.26508/lsa.202402627.

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Upon hormonal stimulation, uterine endometrial stromal cells undergo a dramatic morpho-functional metamorphosis that allows them to secrete large amounts of matrix proteins, cytokines, and growth factors. This step, known as decidualization, is crucial for embryo implantation. We previously demonstrated how the secretory pathway is remodelled during this process. Here we show that hormonal stimulation rapidly induces the expression of many mitochondrial genes, encoded in both the mitochondrial and the nuclear genomes. Altogether, the mitochondrial network quadruples its size and establishes mo
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Reik, Wolf, Fatima Santos, Kohzoh Mitsuya, Hugh Morgan, and Wendy Dean. "Epigenetic asymmetry in the mammalian zygote and early embryo: relationship to lineage commitment?" Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences 358, no. 1436 (2003): 1403–9. http://dx.doi.org/10.1098/rstb.2003.1326.

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Epigenetic asymmetry between parental genomes and embryonic lineages exists at the earliest stages of mammalian development. The maternal genome in the zygote is highly methylated in both its DNA and its histones and most imprinted genes have maternal germline methylation imprints. The paternal genome is rapidly remodelled with protamine removal, addition of acetylated histones, and rapid demethylation of DNA before replication. A minority of imprinted genes have paternal germline methylation imprints. Methylation and chromatin reprogramming continues during cleavage divisions, but at the blas
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Chen, Xinxin, Jun Wang, Donna Woltring, Steve Gerondakis, and M. Frances Shannon. "Histone Dynamics on the Interleukin-2 Gene in Response to T-Cell Activation." Molecular and Cellular Biology 25, no. 8 (2005): 3209–19. http://dx.doi.org/10.1128/mcb.25.8.3209-3219.2005.

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ABSTRACT Several models have been proposed for the mechanism of chromatin remodelling across the promoters of inducible genes in mammalian cells. The most commonly held model is one of cooccupation where histone proteins are modified by acetylation or phosphorylation and nucleosomes are remodelled, allowing the assembly of transcription factor complexes. Using chromatin immunoprecipitation, we observed an apparent decrease of histone acetylation and phosphorylation signals at the proximal promoter region of the inducible interleukin-2 and granulocyte-macrophage colony-stimulating factor genes
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Dissertations / Theses on the topic "Remodelled genes"

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Sussfeld, Duncan. "Identifying remote homology and gene remodelling using network-based approaches." Electronic Thesis or Diss., université Paris-Saclay, 2024. http://www.theses.fr/2024UPASL112.

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L'augmentation toujours plus importante de données génomiques et métagénomiques appelle de nouveaux développements méthodologiques et bio-informatiques, afin de caractériser avec davantage de précision les phénomènes évolutifs dans leur ensemble. En particulier, certaines des méthodes usuelles pour étudier l'évolution des (familles de) gènes s'avèrent inadaptées lorsque la parenté entre séquences n'est que partiellement supportée. Ainsi, la définition et la reconstruction de familles de gènes se heurtent à l'obstacle de l'homologie distante, qui passe sous le seuil de détection des alignements
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Kreher, Judith [Verfasser], and Alexander [Akademischer Betreuer] Brehm. "Function of the ATP-dependent chromatin remodeler Mi-2 in the regulation of ecdysone dependent genes in Drosophila melanogaster / Judith Kreher. Betreuer: Alexander Brehm." Marburg : Philipps-Universität Marburg, 2015. http://d-nb.info/1070623962/34.

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(6635906), Erin L. Sorlien. "The Chromatin Remodeler and Tumor Suppress Chd5 Promotes Expression and Processing of Transcripts During Development of the Zebrafish Neural System." Thesis, 2019.

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<div>Vertebrate neurogenesis is a multistep process that coordinates complex signaling pathways and chromatin-based regulatory machinery to generate highly specialized cells (Hsieh and Zhao 2016; Urban and Guillemot 2014; Alunni and Bally-Cuif 2016; Yao and Jin 2014; Schmidt, Strahle, and Scholpp 2013). Epigenetic factors play a fundamental role in underwriting neurogenesis in part by contributing to control of gene expression in differentiating neurons. A mechanistic understanding of the epigenetic machinery underlying neurogenesis in vertebrates is necessary both to fully understand biogene
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Books on the topic "Remodelled genes"

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Yang, Jin, Pei Han, Wei Li, and Ching-Pin Chang. Epigenetics and post-transcriptional regulation of cardiovascular development. Edited by José Maria Pérez-Pomares, Robert G. Kelly, Maurice van den Hoff, et al. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198757269.003.0032.

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Cardiac organogenesis requires the control of gene expression at distinct developmental windows in order to organize morphogenetic steps in the correct sequence for heart development. This is facilitated by concerted regulation at three levels: chromatin, transcription, and post-transcriptional modifications. Epigenetic regulation at the chromatin level changes the chromatin scaffold of DNA to regulate accessibility of the DNA sequence to transcription factors for genetic activation or repression. At the genome, long non-coding RNAs work with epigenetic factors to alter the chromatin scaffold
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Book chapters on the topic "Remodelled genes"

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Cui, Guofei, Qing Dong, Kexin Gai, and Shaohua Qi. "Chromatin Dynamics: Chromatin Remodeler, Epigenetic Modification and Diseases." In Epigenetics - Regulation and New Perspectives [Working Title]. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.108385.

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The gene transcription patterns are regulated in response to extracellular stimuli and intracellular development programs. Recent studies have shown that chromatin dynamics which include nucleosome dynamics and histone modification play a crucial role in gene expression. Chromatin dynamic is regulated by chromatin modification enzymes including chromatin remodeling complex and histone posttranslational modifications. Multiple studies have shown that chromatin dynamics dysregulation and aberrant and histone modifications resulted in the occurrence of various diseases and cancers. Moreover, freq
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Furet, Francois. "The French Revolution or Pure Democracy." In Rewriting the French Revolution. Oxford University PressOxford, 1991. http://dx.doi.org/10.1093/oso/9780198219767.003.0002.

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Abstract The repercussions of the French Revolution are universal because it proclaimed itself to be universal. Independent of the particular conditions of its birth and even of the country in which it broke out, it gave itself the mission not of adjusting institutions to the circumstances of national history or to the state of opinion, but rather of remaking the social contract from top to bottom, as though it were an artefact to be completely reworked, remodelled according to the principles of reasoning will. It was thus an event that was inextricably political and philosophical, and contemp
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Pal, Neeraj, Dinesh Kumar Saini, and Sundip Kumar. "Breaking Yield Ceiling in Wheat: Progress and Future Prospects." In Wheat [Working Title]. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.102919.

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Wheat is one of the most important staple crops that contribute considerably to global food and nutritional security. The future projections of the demand for wheat show significant enhancement owing to the population growth and probable changes in diets. Further, historical yield trends show a reduction in the relative rate of gain for grain yield over time. To maintain future food security, there is a strong need to find ways to further increase the yield potential of wheat. Grain yield is a quantitative trait that is highly influenced by the environment. It is determined by various interlin
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Adam, Véronique. "Poétique du cliché dans la première partie des Œuvres poétiques de Théophile de Viau." In Styles, genres, auteurs 8 : Jean Bodel, Adam de la Halle, Des Périers, Viau, Voltaire, Hugo, Bernanos. Sorbonne Université Presses, 2008. https://doi.org/10.70551/azts6468.

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Le cliché est un élément de la littérarité du texte et le signe d’un travail poétique à deux niveaux : il est présent comme outil rhétorique, que l’on va remodeler, et comme sujet d’une réflexion sur la poésie. Outil, il est la plupart du temps combiné à d’autres clichés et lieux communs. Si dans l’univers amoureux, cette combinaison construit simplement une isotopie, soulignant bien l’immédiateté et la banalité du cliché, le genre polémique fait de lui le signe d’une contestation des lieux communs, non plus parole répétée d’un autre, mais signe d’une énonciation personnelle. La réception du c
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Conference papers on the topic "Remodelled genes"

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Dey, Nandini, Jennifer C. Aske, Ethan Thompson, Luis Rojas-Espaillat, David Starks, and Pradip De. "Abstract 1427: Co-alteration of the nucleosome remodeler, ARID1A with the PI3K-pathway genes: A signaling opportunity in ovarian cancers." In Proceedings: AACR Annual Meeting 2020; April 27-28, 2020 and June 22-24, 2020; Philadelphia, PA. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1538-7445.am2020-1427.

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