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Relevant bibliographies by topics / Renal Pathology / Dissertations / Theses

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Dissertations / Theses on the topic 'Renal Pathology'

Author: Grafiati

Published: 5 September 2021

Last updated: 27 July 2025

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1

Morrissey, Catherine. "The molecular pathology of renal cell carcinoma." Thesis, University of Birmingham, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.420407.

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2

Hard, Gordon Charles. "Renal Carcinogenesis: Animal Models, Toxicologic Pathology And Risk Assessment." Thesis, The University of Sydney, 2015. http://hdl.handle.net/2123/13990.

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This thesis presented for Doctor of Veterinary Science is a collection of 50 papers dealing with aspects of experimental renal carcinogenesis published in peer-reviewed cancer research, pathology and toxicology journals, or in one case, in a WHO International Agency for Research on Cancer (IARC) volume. The work, conducted from 1979 since award of Doctor of Science to the present (2014), concerns the further development of animal models of kidney cancer, the modes-of-action of certain chemical compounds in the induction of renal toxicity and carcinogenesis, and toxicologic pathology of the rod

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3

Al-Sharhan, Mouza Abdulla. "Prognostic factors in renal cell carcinoma." Thesis, University of Newcastle Upon Tyne, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.285788.

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4

Silberberg, Jonathan S. "Left ventricular hypertrophy in end-stage renal disease." Thesis, McGill University, 1989. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=61836.

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5

Madlala, Siphelele Clifford. "The role of stem cells and WNT signalling pathway in renal cell carcinoma." Master's thesis, Faculty of Health Sciences, 2020. http://hdl.handle.net/11427/32358.

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Introduction: Renal cell carcinoma (RCC) accounts for 87% of all kidney cancers. Despite advances in diagnostic techniques and management, renal cell carcinoma remains a lethal tumour accounting for substantial mortality and morbidity. The poor prognosis arises from metastasis, chemoradiation resistance and disease relapse. Cancer stem cells, a subpopulation of tumour cells with capacity to self-renew and reconstitute tumour heterogeneity have been implicated as the root cause of poor prognosis. Therefore, a better understanding of biomarkers of cancer stem cells will be useful for risk strati

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6

Qayyum, Tahir. "The role of Src kinase in renal cell carcinoma." Thesis, University of Glasgow, 2014. http://theses.gla.ac.uk/5600/.

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Renal cancer is a malignancy which is not only increasing in incidence but there has also been an increase in mortality rates. There are various prognostic factors in renal cell cancer. We have demonstrated that some of these such as nuclear grading, tumour necrosis and systemic inflammatory response can be further refined to aid in prognosis but cannot be utilised at present to assess which would benefit from therapeutic agents when recurrence occurs. We investigated if SFK members are expressed in renal cancer. Eight SFK members were found to be expressed in renal cancer and were present to

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7

Gingell-Littlejohn, Marc. "Cellular senescence and renal transplantation." Thesis, University of Glasgow, 2014. http://theses.gla.ac.uk/4986/.

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With the current crisis of organ shortage and an increasing number of dialysis patients,studies directed at ameliorating such a substantial organ discrepancy are of considerable importance to the transplant community. The use of extended criteria donation has helped to compensate the disparity of organs however, we are still a long way from achieving satisfactory targets. Still there are many organs from older donors that are discarded primarily on the basis of chronological age. It is here that biological age may display a crucial role in allowing the transplant team to characterize donor org

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8

Clark, Patsy C. "Caspase inhibitors rescue renal hypoplasia of PAX2 mutant mice." Thesis, McGill University, 2002. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=29423.

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Heterozygous 1Neu mice transmit a single base pair insertion mutation within the paired domain (exon 2) of the PAX2 gene; this mutation is identical to that in humans with Renal-Coloboma Syndrome. In both mice and humans, PAX2 heterozygotes are born with optic colobomas and renal hypoplasia. Previously, we have shown that kidneys of fetal 1Neu mice have increased apoptosis of ureteric bud (UB) cells and reduced UB branching. However, it is unclear whether increased susceptibility to apoptosis is the critical determinant of renal hypoplasia in PAX2 haploinsufficiency.<br>In this study, E13.5 fe

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9

Hueber, Pierre-Alain. "PAX 23 in normal kidney development and as therapeutic targets in renal cancer." Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=103384.

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The PAX gene family of transcription factors plays a prominent role during embryogenesis however can be aberrantly re-activated during tumorigenesis and contributes to the malignant phenotype.<br>During embryonic kidney development, PAX2 exerts an anti-apoptotic function however its expression typically attenuates during the post-natal period. On the other hand, PAX2 aberrant expression is observed in the majority of Renal Cell Carcinomas (RCC). RCC is resistant to chemotherapy; up-regulation of anti-apoptotic genes is recognized to contribute to tumor resistance to chemotherapy. We hypothesiz

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10

Kirk, Adam. "Characterisation of the human renal tight junction barrier and the influence of TGFβ1 and cyclosporine A". Thesis, University of Southampton, 2011. https://eprints.soton.ac.uk/372939/.

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11

Nahorski, Michael Stefan. "Investigation into the molecular mechanisms of inherited renal cancer." Thesis, University of Birmingham, 2012. http://etheses.bham.ac.uk//id/eprint/3663/.

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Birt Hogg Dubé (BHD) syndrome is an inherited cancer susceptibility syndrome characterised by the development of fibrofolliculomas on the face and upper torso, and increased risk of lung cysts, spontaneous pneumothorax and renal cancer. The findings presented in this thesis advance knowledge into how the mutations in the FLCN gene cause the phenotypes associated with BHD syndrome, and provides novel insights into the functions of folliculin within the cell. The results presented provide further evidence of the association between BHD syndrome and increased risk of colorectal cancer in a subse

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12

Tumkur, Sitaram Raviprakash. "Signalling pathways in renal cell carcinoma with a focus on telomerase regulation." Doctoral thesis, Umeå universitet, Patologi, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-38121.

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Telomerase is a ribonucleoprotein complex that catalyses telomeric repeat addition at the ends of chromosomes. The catalytic subunit, hTERT, acts as a key determinant for telomerase activity control; the induction of hTERT expression is required for telomerase activity. hTERT participates in cellular immortalization and is elevated in certain malignant tissues. Several tumours exhibit telomerase activity, which contributes to the infinite proliferation capacity that promotes tumour progression. Renal cell carcinoma (RCC) represents 2% of all adult malignancies and has a high mortality rate. Th

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13

Zhang, Fenz. "Regulation of erythropoiesis in a murine model of chronic renal failure : the relative role of erythropoietin and insulin-like growth factor 1." Thesis, McGill University, 1993. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=69733.

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Anemia is an almost invariable manifestation of chronic renal failure (CRF) and it often contributes substantially to the morbidity of the condition. In its uncomplicated form, this anemia is due primarily to reduced production of erythropoietin (EPO) by the diseased kidney. The present study was carried out in order to determine the relative role in the anemia secondary to CRF of EPO and insulin-like growth factor-1 (IGF-1), a recently recognized important regulatory factor of erythropoiesis in the normal physiological state.<br>A mouse model of CRF was employed in this investigation. Six wee

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14

Alkhateeb, Tuqa. "Effects of Acute Sepsis on Renal Structure and Sympathetic Innervation in Mice." Digital Commons @ East Tennessee State University, 2017. https://dc.etsu.edu/etd/3299.

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Sympathetic nerves are important for renal physiology and sepsis pathophysiology. A recent study showed sprouting of sympathetic nerves in spleen of septic mice. This study was done to test if renal sprouting of sympathetic nerves also happens and to investigate renal morphology in septic mice. Cecal ligation and puncture (CLP) was used to induce sepsis and kidneys were removed for evaluation. Bowman’s space was diminished with cortical bubble cells present suggestive of acute renal pathology, however, renal function was unchanged. Acute sepsis did not affect either renal sympathetic innervati

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15

Antunes, Jacob T. Antunes. "Quantitative Treatment Response Characterization In Vivo: UseCases in Renal and Rectal Cancers." Case Western Reserve University School of Graduate Studies / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=case1467987922.

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16

Chaudry, Qaiser Mahmood. "Improving cancer subtype diagnosis and grading using clinical decision support system based on computer-aided tissue image analysis." Diss., Georgia Institute of Technology, 2013. http://hdl.handle.net/1853/47745.

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This research focuses towards the development of a clinical decision support system (CDSS) based on cellular and tissue image analysis and classification system that improves consistency and facilitates the clinical decision making process. In a typical cancer examination, pathologists make diagnosis by manually reading morphological features in patient biopsy images, in which cancer biomarkers are highlighted by using different staining techniques. This process is subjected to pathologist's training and experience, especially when the same cancer has several subtypes (i.e. benign tumor subtyp

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17

Pinho, Fábia Maria Oliveira. "Insuficiência renal aguda após envenenamento crotálico: prevalência e fatores de risco - um estudo prospectivo." Universidade de São Paulo, 2004. http://www.teses.usp.br/teses/disponiveis/5/5148/tde-10042007-141228/.

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O envenenamento crotálico é responsável por, aproximadamente, 10% dos acidentes causados por serpentes peçonhentas no Brasil. A peçonha crotálica possui ação neurotóxica, miotóxica, nefrotóxica e coagulante. Insuficiência renal aguda (IRA) é a principal complicação nas vítimas que sobrevivem aos efeitos iniciais da peçonha, sendo importante causa de óbito para esses pacientes. Os objetivos deste estudo foram determinar prospectivamente a prevalência e os fatores de risco relacionados ao desenvolvimento de IRA após envenenamento crotálico. Foram estudadas 100 vítimas de acidente crotálico admit

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18

Junior, Renato Falci. ""Tratamento do cisto renal simples sintomático por aspiração percutânea e injeção permanente de álcool absoluto em sessão única"." Universidade de São Paulo, 2005. http://www.teses.usp.br/teses/disponiveis/5/5153/tde-11082005-152335/.

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Foram estudados prospectivamente 33 pacientes cujos cistos tinham volume médio de 298,4 + 346,9 (30 - 1700) ml. A punção foi realizada sob anestesia local com agulha 18 gauge, de 20 cm. Após seu esvaziamento, injetou-se etanol absoluto no volume equivalente a um terço do volume aspirado, até o máximo de 100 ml. Os volume médios observados após um, três e seis meses foram 47,9 + 59,4 (0 - 286) ml, 25,2 + 42,8 (0 - 208) ml e 12,7 + 30 (0 - 120) ml, respectivamente. Após esse período, 30 (91%) apresentaram remissão total dos sintomas, 2 (6%) mantiveram os sintomas, sendo um com cisto residual e o

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19

Matshar, Farah. "Jämförelse av alternativa fixeringslösningar för humana njurbiopsier." Thesis, Högskolan Kristianstad, Sektionen för lärande och miljö, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:hkr:diva-14281.

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Inom klinisk patologi bedöms vävnadsprover under mikroskop, med syftet att fastställa diagnos. Utgångsmaterial är antingen ett helt organ eller en liten bit från det sjukligt förändrade organet. I det senare fallet kallas preparatet för biopsi och dessa tas med hjälp av biopsiverktyg och oftast under ultraljudledning. Njurbiopsier kan tas vid misstänkt transplantatavstötning, av medicinska skäl, vid inflammatoriska tillstånd (nefriter) samt nefrotiska tillstånd. En del av biopsimaterialet fixeras i 4 % formaldehyd för ljusmikroskopisk (LM) bedömning, medan resten transporteras i transportlösni

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20

Prapansilp, Panote. "Molecular pathological investigation of the pathophysiology of fatal malaria." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:e966a2f2-a37d-4586-b09e-2bb616e5dce2.

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Malaria remains one of the world's major health problems, especially in developing countries. A better understanding of the pathology and pathophysiology of severe malaria is key to develop new treatments. Different approaches have been used in malaria research including the in vitro co-culture models with endothelial cells and both murine and simian animal models. However these are open to controversy due to disagreement on their representativeness of human disease. Using human post-mortem tissue in malaria research is another important approach but is practically challenging, limiting the av

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21

Gonçalves, Janaína Garcia. "Avaliação dos eventos envolvidos na evolução crônica da lesão renal aguda pós isquêmica em ratos com deficiência de vitamina D." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/5/5148/tde-29102014-145222/.

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Na maioria dos países, a incidência e prevalência da doença renal crônica (DRC) vem aumentando ao longo dos anos. Embora tenha havido uma melhora significativa no manejo da DRC com os inibidores do sistema renina-angiotensina-aldosterona, a doença ainda é progressiva, levando a necessidade do surgimento de novas estratégias protetoras. A fibrose renal progressiva está presente na DRC e envolve a participação de várias citocinas, com destaque para o fator Transforming growth factor- beta1 (TGF-beta1). Tem sido demonstrado que a mortalidade de pacientes com DRC está diretamente relacionada à fun

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22

Moyses, Zenaide Providello. "N-acetilcisteína melhora os fenótipos renal e cardíaco e reduz o peso corpóreo em camundongos císticos deficientes em Pkd1." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/5/5160/tde-20022014-093915/.

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Estudos experimentais e clínicos amparam a participação do estresse oxidativo na progressão da doença renal na doença renal policística autossômica dominante (DRPAD). A administração do agente antioxidante N-acetilcisteína (NAC), por sua vez, apresenta efeitos benéficos em vários modelos animais de injúria renal. Neste estudo, utilizamos um camundongo cístico gerado por meio do cruzamento de uma linhagem portadora de um alelo floxed Pkd1 com outra que expressa nestin-Cre para avaliar os efeitos da NAC sobre um modelo ortólogo à DRPAD humana. O tratamento de longo prazo com NAC foi iniciado na

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23

Menezes, Luis Fernando Carvalho de. ""Análise do padrão de expressão do produto de PKHD1, o gene mutado na doença renal policística autossômica recessiva"." Universidade de São Paulo, 2004. http://www.teses.usp.br/teses/disponiveis/5/5160/tde-04102005-111547/.

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O gene PKHD1, mutado na doença renal policística autossômica recessiva, apresenta um padrão de splicing complexo associado a múltiplos transcritos alternativos. Neste trabalho estudamos o perfil de expressão de seu produto, poliductina. Análises por western blot revelaram produtos putativos de membrana de > 440 kDa e ~230 kDa, e de ~140 kDa em frações solúveis de rim, fígado e pâncreas. Estudos imunoistoquímicos mostraram marcação em ductos coletores renais e porção ascendente espessa da alça de Henle, em epitélios ductais biliar e pancreático e, no período embrionário, em broto ureteral, duct

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24

Li, Wei Chen. "Supporting Pathology Process Management with Real-time Business Intelligence." Thesis, Université d'Ottawa / University of Ottawa, 2016. http://hdl.handle.net/10393/35329.

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[Context] Clinical pathology is a medical specialty that uses laboratory analysis of tissues and fluids to diagnose diseases. As emerging methodologies and technologies extend their realm to anatomical pathology, pathology facilities are faced with new challenges related to the increasing volume and complexity of patient cases in their work processes. [Problem] Existing tools that monitor process data show limitations in supporting pathology process management. They lack the capability of identifying emerging process bottlenecks in a real-time manner, and this prevents facility managers from c

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25

Fauron, Sylvie. "Pathologie des arteres renales : deux ans d'experience dans un service de nephrologie." Clermont-Ferrand 1, 1990. http://www.theses.fr/1990CLF13028.

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26

Laclotte-Giacometti, Pascale. "Enzymurie et pathologie rénale." Bordeaux 2, 1993. http://www.theses.fr/1993BOR2P032.

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27

Bouillez, Audrey. "Implication de la mucine membranaire MUC1 dans la progression tumorale rénale et identification de nouvelles cibles thérapeutiques." Phd thesis, Université du Droit et de la Santé - Lille II, 2014. http://tel.archives-ouvertes.fr/tel-01062692.

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Le carcinome rénal représente 5% des tumeurs de l'adulte et se développe au niveau des tubules rénaux. Le sous-type histologique majeur des cancers du rein est le carcinome rénal à cellules claires (cRCC). 90% des cRCC présentent une inactivation biallélique du gène suppresseur de tumeur de Von Hippel Lindau (VHL) induisant une activation constitutive de la voie de l'hypoxie via le facteur de transcription HIF1-α (Hypoxia Inducible Factor) qui contribue à la physiologie des tumeurs. Les cRCC sont des tumeurs à la fois radio- et chimiorésistantes, rendant la prise en charge thérapeutique des pa

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28

Nouël, Alexandre. "Étude du lymphocyte B au cours du rejet d'allogreffe rénale." Phd thesis, Université de Bretagne occidentale - Brest, 2013. http://tel.archives-ouvertes.fr/tel-00951978.

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Le rejet d'allogreffe représente un obstacle majeur en transplantation rénale humaine. Le lymphocyte B (LB) joue un rôle lors de cette réaction contre le greffon, mal défini à ce jour. Notre objectif a été de caractériser et identifier son implication dans le rejet humoral chronique (cABMR) et le rejet cellulaire aigu (ACR). Dans une première partie, la caractérisation phénotypique des LB par cytométrie en flux chez ces patients a mis en évidence d'importantes différences dans la distribution des sous-populations de LB uniquement chez les patients cABMR. Chez les patients ACR, dont la distribu

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29

GAILLANDRE, LOIC. "Scanographie spiralee en pathologie renale : qualite d'image et applications cliniques." Lille 2, 1994. http://www.theses.fr/1994LIL2M241.

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30

Price, Brendon. "Human Papillomavirus DNA extraction and genotype analysis by multiplex real time polymerase chain reaction from formalin fixed paraffin wax-embedded cervical carcinoma specimens." Master's thesis, Faculty of Health Sciences, 2019. http://hdl.handle.net/11427/31189.

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Introduction: Cervical squamous cell carcinoma is most commonly caused by persistent infection by high risk human papillomavirus (hrHPV) genotypes. The exact type of hrHPV varies geographically and is the basis for HPV–based vaccination for cervical squamous cell carcinoma prevention. Little is known regarding local hrHPV genotypes within the Western Cape population of South Africa. Aims and objectives: This was a pilot study aiming to extract of high quality genomic DNA from archival FFPE cervical squamous cell carcinoma cases and identify hrHPV genotypes by multiplex real time PCR (RT-PCR).

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31

RICHER-DROZ, DOMINIQUE. "Caracterisation immunohistochimique des cellules inflammatoires et des cellules parenchymateuses en pathologie renale." Paris 6, 1990. http://www.theses.fr/1990PA066293.

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Utilisant des anticorps monoclonaux diriges contre les lymphocytes t et b, les macrophages, les constituants du cytosquelette, les matrices extracellulaires, les antigenes hla de classe i et de classe ii, nous avons caracterise les cellules impliquees dans diverses maladies renales humaines. Les infiltrats interstitiels des nephropathies sont faits de cellules t et de macrophages. Les lymphocytes t cd4 positifs sont plus nombreux dans les nephrites interstitielles liees a la prise d'antibiotiques et celles de la sarcoidose, alors que les cellules t cd8 positives predominent dans celles dues au

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32

Waddel, Matt Burns 1960. "Real time remote microscope control over the Internet." Thesis, The University of Arizona, 1992. http://hdl.handle.net/10150/291659.

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Telepathology systems were developed to allow pathologists to perform remote diagnosis and consultations. These systems have the following essential components; a remote controlled microscope, a video processing system, a communication link, and a user interface and display. This thesis defines a telepathology communication system based on the Internet network. The basic telepathology system problems were addressed: (1) Determining available network bandwidth, (2) Investigating video image compression, (3) Developing a user interface and display. A software model of the telepathology system wa

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33

Seleka, Mpho Maria. "Development of selective real-time PCR (SPCR) asays for the detection of K103N resistance mutation in minor HIV-1 populations." Thesis, Stellenbosch : Stellenbosch University, 2011. http://hdl.handle.net/10019.1/18028.

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Thesis (MScMedSc)--Stellenbosch University, 2011.<br>ENGLISH ABSTRACT: Background: The conventional sequence analysis is the most common method used for the detection of drug-resistant mutants. Due to its sensitivity limitations, it is unable to detect these mutants when comprising less than 20% (minor populations) of the total virus population in a sample. However, real-time PCR-based assays offer a rapid, sensitive, specific and easy detection and quantification of such mutants. The HIV-1 variants harbouring the K103N mutation are associated with resistance to nevirapine (NVP) and efavirenz

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34

Welling, Duane Bradley. "Vestibular schwannoma dissecting the pathologic process and clinical applications /." Columbus, OH : Ohio State University, 2003. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1053706721.

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Thesis (Ph. D.)--Ohio State University, 2003.<br>Title from first page of PDF file. Document formatted into pages; contains xv, 127 p.: ill. (some col.). Includes abstract and vita. Advisor: Cheng Long-Sheng, Dept. of Pathology. Includes bibliographical references (p. 106-127).

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Sztrymf, Benjamin. "Prise en charge et facteurs pronostiques des épisodes d'insuffisance circulatoire aiguë chez des patients atteints d'Hypertension Artérielle pulmonaire." Phd thesis, Université Paris Sud - Paris XI, 2013. http://tel.archives-ouvertes.fr/tel-00920148.

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L'hypertension artérielle pulmonaire (HTAP) est une maladie caractérisée par une obstruction des artères pulmonaires de petit calibre aboutissant, à terme, à une défaillance cardiaque droite. L'évolution de cette maladie est parfois émaillée d'épisodes de dégradation de l'état fonctionnel des patients, nécessitant une admission en unité de soins intensifs pour surveillance cardioscopique et administration de médicaments inotropes et/ou vasopresseurs. Peu d'éléments permettent à ce jour de guider les praticiens dans la prise en charge de ces patients et la physiopathologie de ces épisodes est a

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36

TRAN-VAN, PATRICIA. "Pathologie vasculo-renale chronique et grossesse : interet des examens complementaires ; a propos de 58 grossesses." Toulouse 3, 1992. http://www.theses.fr/1992TOU31553.

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37

Lemy, Anne. "Do MICA antibodies impact on renal graft outcomes?" Doctoral thesis, Universite Libre de Bruxelles, 2012. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209617.

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La transplantation rénale représente le traitement de choix de l’insuffisance rénale terminale parce qu’il offre une espérance de vie plus longue et une meilleure qualité de vie.<p>Néanmoins, l’accès à la transplantation est limité par la pénurie d’organes et dans certains cas, par la présence d’anticorps anti-HLA avant la greffe.<p>Bien que la présence d’anticorps anti-HLA spécifiques du donneur avant ou après la greffe ait été associée au rejet aigu et à la perte chronique d’allogreffe, un rejet humoral tant aigu que chronique peut survenir sans que ces anticorps soient détectables dans le s

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38

Joshi, Lovleen Tina. "Pathogenicity & a bedside real-time detection assay for clostridium difficile in the faeces of hospitalized patients." Thesis, Cardiff University, 2012. http://orca.cf.ac.uk/37079/.

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Clostridium difficile, a Gram positive, anaerobic, spore-forming bacterium is the commonest cause of hospital acquired infection in the UK. The organism initiates infection through spore formation and attachment, germination in the gut and then the production of two potent cytotoxins; toxins A and B. While the contribution of toxins A and B to infection is beyond dispute the relative importance of each toxin is a subject of debate. Thus diagnostic assays capable of rapidly detecting the presence of both toxins are needed. To develop such an assay we first characterised the structure of C. diff

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39

Ferlicot, Sophie. "Etude des Telomères : de la telomerase et de la senescence replicative en pathologie hepatique et renale." Paris 7, 2004. http://www.theses.fr/2004PA077069.

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40

Fisher, Leslie Reginald. "Evaluation of high-throughput methodology for multi-gene screening in patients with Non-Alcoholic Fatty Liver Disease (NAFLD)." Thesis, Stellenbosch : Stellenbosch University, 2011. http://hdl.handle.net/10019.1/17896.

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Thesis (MScMedSc)--Stellenbosch University, 2011.<br>ENGLISH ABSTRACT: Non-Alcoholic Fatty Liver Disease (NAFLD) is the most prevalent chronic liver disease in Western countries and is considered the hepatic manifestation of the Metabolic Syndrome (MetS). Its heterogeneous nature ranges from hepatic steatosis through steatohepatitis to advanced fibrosis and cirrhosis where the ingestion of significant amounts of alcohol has been excluded. The disease profile of NAFLD and its necro-inflammatory subset Nonalcoholic Steatohepatitis (NASH) were described in the parent study, which provided a clini

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Costa, Marcelo Maciel da. "Marcadores prognósticos na nefropatia isquêmica em pacientes submetidos à intervenção terapêutica (angioplastia com ou sem implante de stent)." Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/5/5148/tde-17102014-120044/.

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A nefropatia isquêmica é caracterizada pela piora da função renal e perda de massa renal decorrente de uma estenose hemodinamicamente significativa. A reversibilidade potencial da injúria renal após intervenção terapêutica é ponto crucial. A intervenção terapêutica tem como objetivo restabelecer um fluxo renal adequado e conseqüentemente melhorar a taxa de filtração glomerular e obter um melhor controle pressórico. Objetivo: avaliar e comparar os marcadores prognósticos tradicionais e novos (quantificação da ecogenicidade renal - relação parênquimo-sinusal (RPS) e histologia renal) na nefropat

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Fretellier, Nathalie. "Rôle des complexes de gadolinium dans le mécanisme de la fibrose systémique néphrogénique." Phd thesis, Université René Descartes - Paris V, 2013. http://tel.archives-ouvertes.fr/tel-00843108.

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La fibrose systémique néphrogénique (FSN) est une maladie rare et relativement récente, observée uniquement chez des patients souffrant d'insuffisance rénale sévère ou terminale. Elle est liée à l'administration d'une certaine catégorie de complexes de gadolinium (CG), les CGs thermodynamiquement moins stables, utilisés comme produits de contraste pour l'imagerie par résonance magnétique. L'hypothèse mécanistique la plus couramment citée concerne les effets profibrosants du Gd3+ " libre " après dissociation in vivo des CGs les moins stables mais il n'en existe pas de démonstration formelle. La

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MIGNOT, GARMY MARIE-FRANCOISE. "Etude du complexe thrombine - antithrombine au cours des pathologies vasculo-renales de la grossesse : a propos de 38 cas." Toulouse 3, 1993. http://www.theses.fr/1993TOU31052.

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Snanoudj, Renaud. "Lymphocytes B mémoire dans la réponse humorale anti-HLA en transplantation d'organe." Phd thesis, Université René Descartes - Paris V, 2013. http://tel.archives-ouvertes.fr/tel-00919770.

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Les alloanticorps anti-HLA sont dirigés vis-à-vis de différents épitopes des molécules du système HLA. Cette immunisation survient lors d'une transplantation d'organe, de transfusions sanguines ou d'une grossesse. On retrouve aussi ces anticorps, lorsque les techniques de détection sont sensibles, en l'absence de tout évènement immunisant. En transplantation d'organe, rénale en particulier, la présence d'anticorps anti-HLA, du fait des lésions de rejet humoral qu'ils induisent, constitue une des premières causes de perte de fonction des greffons à moyen et long terme. Néanmoins, les cellules l

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Aljawasim, Baker Diwan Getheeth. "Evaluation of PCR-Based Methods for Rapid, Accurate Detection and Monitoring of Verticillium Dahliae in Woody Hosts by Real-Time Polymerase Chain Reaction." UKnowledge, 2014. http://uknowledge.uky.edu/plantpath_etds/13.

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Verticillium wilt, caused by Verticillium dahliae Kleb, is one of the most economically important diseases of woody hosts such as ash (Fraxinus spp.), sugar maple (Acer saccharum), and redbud (Cercis canadensis). The causal agent has a broad host range, including not only woody hosts but also important vegetable and field crops, and it is distributed worldwide. Diagnosis of V. dahliae in infected woody hosts is often based on the occurrence of vascular discoloration and time-consuming isolation. However, not all woody hosts exhibit vascular discoloration symptoms, and not all vascular discolor

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Outifrakh, Abdeslam. "Rein et eicosanoides : nephrose experimentale chez le rat." Université Louis Pasteur (Strasbourg) (1971-2008), 1988. http://www.theses.fr/1988STR13152.

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Etude sur glomerules isoles de rats presentant une nephropathie glomerulaire experimentale, recherche de l'action de l'hormone peptidique, facteur anf, sur cette voie metabolique. Excretion accrue de thromboxane b2 urinaire, modifications de prostaglandines e2 et de 6-ceto prostaglandine f1. Pas de modification significative de la biosynthese glomerulaire des hete

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Gloulou, Basma. "Identification et caractérisation des cellules tumorales circulantes dans le cancer rénal à cellules claires." Phd thesis, Université René Descartes - Paris V, 2012. http://tel.archives-ouvertes.fr/tel-00806775.

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La diffusion dans le sang des cellules tumorales circulantes (CTC) à partir de la tumeur primitive est un signe précoce d'invasivité tumorale et du risque de développer des métastases. Par conséquent, la capacité à les détecter de façon très sensible et spécifique est censée constituer un test cliniquement important pour le pronostic du cancer, le suivi des patients et la personnalisation de la thérapie. Les CTC sont des cellules rares, et plusieurs méthodes ont été proposées pour leur détection. La technique ISET (Isolation by Size of Epithelial/Tumor cells) se base sur la différence de taill

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Santos, Ricardo Virginio dos. "Avaliação das lesões obstrutivas dos principais vasos de drenagem venosa dos membros superiores nos pacientes em hemodiálise." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/5/5148/tde-12092008-143711/.

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Introdução: A integridade do Sistema Venoso Central é uma condição fundamental para criar ou manter um acesso vascular eficiente para hemodiálise. A cateterização da veia subclávia é a principal responsável pelo desenvolvimento de obstruções nesses vasos. Porém, é preciso reavaliar a distribuição dessas lesões na atual época de priorização da cateterização da veia jugular interna. Objetivo: Avaliar a distribuição anatômica das obstruções no Sistema Venoso Central dos pacientes em hemodiálise com sinais clínicos de hipertensão venosa. Método e Material: foi realizado um estudo prospectivo de ca

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Iranparvar, Alamdari Farhood. "Renal cell carcinoma : factors of importance for follow-up and survival." Doctoral thesis, Umeå : Univ, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1418.

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Oliveira, Rita de Cássia. "Perfil de expressão de microRNAs envolvidos na regulação de genes associados à angiogênese no carcinoma renal das células claras." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/5/5153/tde-26012017-102913/.

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INTRODUÇÃO: O Carcinoma de Células Renais (CCR) é reposnsável por mais de 200.000 casos a cada ano no mundo, representando cerca de 2% de todos os cânceres. O CCR do tipo células claras (CRCC) é o subtipo mais comum da doença e é responsável por 75 a 80% dos casos, com maiores taxas de invasão local, desenvolvimento de metástases e mortalidade. As novas terapias alvo são baseadas em moléculas e anticorpos antiangiogênicos alterando o curso da doença, mas os resultados até agora não são satisfatórios. OBJETIVOS: Nosso objetivo nesse estudo foi estudar miRNAs e seus possíveis genes alvo relacion

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