Relevant bibliographies by topics / Renal progenitors

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'Renal progenitors'

Author: Grafiati
Published: 10 March 2023
Last updated: 31 July 2025

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Journal articles on the topic "Renal progenitors"

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Hasegawa, Sho, Tetsuhiro Tanaka, and Masaomi Nangaku. "Recent advances in renal regeneration." F1000Research 8 (February 25, 2019): 216. http://dx.doi.org/10.12688/f1000research.17127.1.

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Regeneration of a functional kidney from pluripotent stem cells (PSCs) is challenging because of its complex structure. Kidneys are derived from embryonic metanephros, which are composed of three progenitor cells: nephron progenitors, ureteric bud, and stromal progenitors. Nephron progenitors and ureteric bud have been induced successfully from PSCs as a result of the understanding of their detailed developmental process through cell-lineage tracing analysis. Moreover, these induced progenitors can be used to reconstruct the three-dimensional (3D) structure of kidneys in vitro, including glome
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Al-Marsoummi, Sarmad, Aaron A. Mehus, Swojani Shrestha, et al. "Proteasomes Are Critical for Maintenance of CD133+CD24+ Kidney Progenitor Cells." International Journal of Molecular Sciences 24, no. 17 (2023): 13303. http://dx.doi.org/10.3390/ijms241713303.

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Kidney progenitor cells, although rare and dispersed, play a key role in the repair of renal tubules after acute kidney damage. However, understanding these cells has been challenging due to the limited access to primary renal tissues and the absence of immortalized cells to model kidney progenitors. Previously, our laboratory utilized the renal proximal tubular epithelial cell line, RPTEC/TERT1, and the flow cytometry technique to sort and establish a kidney progenitor cell model called Human Renal Tubular Precursor TERT (HRTPT) which expresses CD133 and CD24 and exhibits the characteristics
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Sequeira-Lopez, Maria Luisa S., Eugene E. Lin, Minghong Li, Yan Hu, Curt D. Sigmund, and R. Ariel Gomez. "The earliest metanephric arteriolar progenitors and their role in kidney vascular development." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 308, no. 2 (2015): R138—R149. http://dx.doi.org/10.1152/ajpregu.00428.2014.

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The development of the kidney arterioles is poorly understood. Mature arterioles contain several functionally and morphologically distinct cell types, including smooth muscle, endothelial, and juxtaglomerular cells, and they are surrounded by interconnected pericytes, fibroblasts, and other interstitial cells. We have shown that the embryonic kidney possesses all of the necessary precursors for the development of the renal arterial tree, and those precursors assemble in situ to form the kidney arterioles. However, the identity of those precursors was unclear. Within the embryonic kidney, sever
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Peired, Anna Julie, Maria Elena Melica, Alice Molli, Cosimo Nardi, Paola Romagnani, and Laura Lasagni. "Molecular Mechanisms of Renal Progenitor Regulation: How Many Pieces in the Puzzle?" Cells 10, no. 1 (2021): 59. http://dx.doi.org/10.3390/cells10010059.

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Kidneys of mice, rats and humans possess progenitors that maintain daily homeostasis and take part in endogenous regenerative processes following injury, owing to their capacity to proliferate and differentiate. In the glomerular and tubular compartments of the nephron, consistent studies demonstrated that well-characterized, distinct populations of progenitor cells, localized in the parietal epithelium of Bowman capsule and scattered in the proximal and distal tubules, could generate segment-specific cells in physiological conditions and following tissue injury. However, defective or abnormal
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Holmes, David. "Budding renal progenitors." Nature Reviews Nephrology 10, no. 1 (2013): 4. http://dx.doi.org/10.1038/nrneph.2013.245.

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Phua, Yu Leng, Kevin Hong Chen, Shelby L. Hemker, et al. "Loss of miR-17~92 results in dysregulation of Cftr in nephron progenitors." American Journal of Physiology-Renal Physiology 316, no. 5 (2019): F993—F1005. http://dx.doi.org/10.1152/ajprenal.00450.2018.

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We have previously demonstrated that loss of miR-17~92 in nephron progenitors in a mouse model results in renal hypodysplasia and chronic kidney disease. Clinically, decreased congenital nephron endowment because of renal hypodysplasia is associated with an increased risk of hypertension and chronic kidney disease, and this is at least partly dependent on the self-renewal of nephron progenitors. Here, we present evidence for a novel molecular mechanism regulating the self-renewal of nephron progenitors and congenital nephron endowment by the highly conserved miR-17~92 cluster. Whole transcript
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Montenegro, Francesca, Francesca Giannuzzi, Angela Picerno, et al. "How Stem and Progenitor Cells Can Affect Renal Diseases." Cells 13, no. 17 (2024): 1460. http://dx.doi.org/10.3390/cells13171460.

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Stem and progenitor cells have been observed to contribute to regenerative processes in acute renal failure and chronic kidney disease. Recent research has delved into the intricate mechanisms by which stem and progenitor cells exert their influence on kidney diseases. Understanding how these cells integrate with the existing renal architecture and their response to injury could pave the way for innovative treatment strategies aimed at promoting kidney repair and regeneration. Overall, the role of stem and progenitor cells in kidney diseases is multifaceted, with their ability to contribute to
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Volovelsky, Oded, Thi Nguyen, Alison E. Jarmas, et al. "Hamartin regulates cessation of mouse nephrogenesis independently of Mtor." Proceedings of the National Academy of Sciences 115, no. 23 (2018): 5998–6003. http://dx.doi.org/10.1073/pnas.1712955115.

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Nephrogenesis concludes by the 36th week of gestation in humans and by the third day of postnatal life in mice. Extending the nephrogenic period may reduce the onset of adult renal and cardiovascular disease associated with low nephron numbers. We conditionally deleted either Mtor or Tsc1 (coding for hamartin, an inhibitor of Mtor) in renal progenitor cells. Loss of one Mtor allele caused a reduction in nephron numbers; complete deletion led to severe paucity of glomeruli in the kidney resulting in early death after birth. By contrast, loss of one Tsc1 allele from renal progenitors resulted in
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Peired, Anna Julie, Giulia Antonelli, Maria Lucia Angelotti, et al. "Acute kidney injury promotes development of papillary renal cell adenoma and carcinoma from renal progenitor cells." Science Translational Medicine 12, no. 536 (2020): eaaw6003. http://dx.doi.org/10.1126/scitranslmed.aaw6003.

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Acute tissue injury causes DNA damage and repair processes involving increased cell mitosis and polyploidization, leading to cell function alterations that may potentially drive cancer development. Here, we show that acute kidney injury (AKI) increased the risk for papillary renal cell carcinoma (pRCC) development and tumor relapse in humans as confirmed by data collected from several single-center and multicentric studies. Lineage tracing of tubular epithelial cells (TECs) after AKI induction and long-term follow-up in mice showed time-dependent onset of clonal papillary tumors in an adenoma-
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Rymer, Christopher, Jose Paredes, Kimmo Halt, et al. "Renal blood flow and oxygenation drive nephron progenitor differentiation." American Journal of Physiology-Renal Physiology 307, no. 3 (2014): F337—F345. http://dx.doi.org/10.1152/ajprenal.00208.2014.

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During kidney development, the vasculature develops via both angiogenesis (branching from major vessels) and vasculogenesis (de novo vessel formation). The formation and perfusion of renal blood vessels are vastly understudied. In the present study, we investigated the regulatory role of renal blood flow and O2 concentration on nephron progenitor differentiation during ontogeny. To elucidate the presence of blood flow, ultrasound-guided intracardiac microinjection was performed, and FITC-tagged tomato lectin was perfused through the embryo. Kidneys were costained for the vasculature, ureteric
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Dissertations / Theses on the topic "Renal progenitors"

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Hoshina, Azusa. "Development of new method to enrich human iPSC-derived renal progenitors using cell surface markers." Kyoto University, 2018. http://hdl.handle.net/2433/235064.

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Supplementary information 追加（2019-09-30)<br>Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(医学)<br>甲第21344号<br>医博第4402号<br>新制||医||1031(附属図書館)<br>京都大学大学院医学研究科医学専攻<br>(主査)教授 柳田 素子, 教授 山下 潤, 教授 江藤 浩之<br>学位規則第4条第1項該当
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Lund-Ricard, Yasmine. "Insights From The Small-Spotted Catshark : Kidney Development And The Persistence Of Renal Progenitor Cells In A Chondrichthyes Model." Electronic Thesis or Diss., Sorbonne université, 2023. http://www.theses.fr/2023SORUS130.

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Certains vertébrés peuvent régénérer des néphrons, l'unité fonctionnelle du rein. Cette capacité (la néonéphrogenèse) dépend de la présence de progéniteurs rénaux qui vont se différentier en les cellules du néphron. Pendant le développement des mammifères, les progéniteurs rénaux arrêtent de proliférer et se différencient autours de la naissance alors que d'autres vertébrés maintiennent leurs progéniteurs rénaux après le développement embryonnaire. Ainsi, après la perte de néphrons chez les mammifères, seule une réponse hypertrophique est observée. En contraste, la formation de novo de néphron
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Cañas, Solé Laura. "Determinació de cèl·lules progenitores endotelials, malaltia renal crònica i factors de risc cardiovascular." Doctoral thesis, Universitat Autònoma de Barcelona, 2016. http://hdl.handle.net/10803/399223.

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Introducció: La malaltia cardiovascular és la principal causa de mortalitat en els pacients amb malaltia renal crònica (MRC), tant en hemodiàlisi (HD) com en els pacients trasplantats renals. Els principals factors de risc cardiovascular dels pacients amb MRC,així com els factors de risc propis de la urèmia, produeixen disfunció endotelial en aquest grup de pacients. Aquesta disfunció endotelial incrementa la morbiditat cardiovascular en aquest grup de pacients. Les cèl.lules progenitores endotelials (CPE) són cèl·lules derivades del moll de l’os, presents en sang perifèrica i que tenen la c
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Zanusso, Ilenia. "Acellular matrices as tool for renal progenitor differentiation studies and tissue engineering of blood vessels." Doctoral thesis, Università degli studi di Padova, 2013. http://hdl.handle.net/11577/3423024.

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AMs seem to be a very promising scaffold in TE and can be considered as temporary inductive site-appropriate templates to support the growth, differentiation, and function of the parenchymal cell population of each organ. Nowadays, TE techniques are used both to develop tissue substitutes ex vivo and as reliable tool to investigate cell behaviour, differentiation and proliferation in 3-dimentional environments. In this work the following two different projects have investigated both potentialities using tissue-specific AMs: 1- influence of AMs on differentiation of kidney progenitor cells f
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Borges, Francielly Pinheiro da Silva. "Citomegalovírus em pacientes submetidos a transplante de células progenitoras hematopoiéticas." Universidade Federal de Goiás, 2016. http://repositorio.bc.ufg.br/tede/handle/tede/5801.

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Submitted by Luciana Ferreira (lucgeral@gmail.com) on 2016-08-03T12:26:28Z No. of bitstreams: 2 Dissertação - Francielly Pinheiro da Silva Borges - 2016.pdf: 3852166 bytes, checksum: 70bbe6c9a7c6c0aa1e10b9e7e9d49843 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)<br>Approved for entry into archive by Luciana Ferreira (lucgeral@gmail.com) on 2016-08-03T12:29:55Z (GMT) No. of bitstreams: 2 Dissertação - Francielly Pinheiro da Silva Borges - 2016.pdf: 3852166 bytes, checksum: 70bbe6c9a7c6c0aa1e10b9e7e9d49843 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e
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Chang, Claudia Veiga. "Análise de marcadores de células-tronco/progenitoras em hipófises de modelos animais com hipopituitarismo." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/5/5135/tde-03122013-115816/.

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Introdução: As células-tronco apresentam capacidade de proliferação, autorrenovação, potencial de diferenciação e já foram descritas na hipófise estando envolvidas na renovação celular e regulação homeostática, porém pouco se sabe sobre o seu perfil de expressão nos quadros de hipopituitarismo. Dentre os marcadores de células-tronco descritos previamente na hipófise, destacam-se os genes Sox2, Nanog, Nestina, Cd44 e Oct4. Outro marcador, o gene Nr2e1 (Tlx), encontrado em células-tronco neuronais, apresenta-se elevado durante a embriogênese e na vida adulta no cérebro de camundongos, mas, até o
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Jian, Motamedi Fariba. "Les fonctions vitales de WT1 au cours de la vie des cellules progénitrices du rein embryonnaire." Thesis, Nice, 2015. http://www.theses.fr/2015NICE4099.

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Le développement du rein est un exemple intriguant d’un équilibre délicat entre la prolifération des cellules progénitrices, la différentiation et l’apoptose. Le gène Wt1 est indispensable pour la survie des cellules progénitrices. Le but de cette thèse a été de définir les voies de signalisation activées par Wt1 pendant le développement du rein. En utilisant les souris Wt1 KO, nous avons démontré que WT1 coordonne l’action de deux voies de signalisation opposées : Fgf et Bmp/Smad intervenant dans la survie des cellules progénitrices rénales. Dans une deuxième étude, nous avons analysé le rôle
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Jian, Motamedi Fariba. "Les fonctions vitales de WT1 au cours de la vie des cellules progénitrices du rein embryonnaire." Electronic Thesis or Diss., Nice, 2015. http://www.theses.fr/2015NICE4099.

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Le développement du rein est un exemple intriguant d’un équilibre délicat entre la prolifération des cellules progénitrices, la différentiation et l’apoptose. Le gène Wt1 est indispensable pour la survie des cellules progénitrices. Le but de cette thèse a été de définir les voies de signalisation activées par Wt1 pendant le développement du rein. En utilisant les souris Wt1 KO, nous avons démontré que WT1 coordonne l’action de deux voies de signalisation opposées : Fgf et Bmp/Smad intervenant dans la survie des cellules progénitrices rénales. Dans une deuxième étude, nous avons analysé le rôle
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NARDI, SARA. "Studio dell'effetto di un danno renale acuto sulla formazione di carcinoma renale." Doctoral thesis, 2019. http://hdl.handle.net/2158/1154908.

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Lo studio affrontato in questa tesi ha evidenziato come il danno renale acuto possa influire sullo sviluppo di carcinoma renale, e in particolare delle forme papillari di carcinoma, agendo sulla via di segnalazione di Notch. Abbiamo preso in considerazione una popolazione di progenitori renali localizzati tra le cellule epiteliali parietali (PEC) e le cellule epiteliali tubulari (TEC), la cui proliferazione e differenziazione è controllata dalla via di segnalazione di Notch. Abbiamo lavorato in vivo allestendo linee murine transgeniche in cui i progenitori renali sono identificati dal marcato
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Antonelli, Giulia. "Studio delle pathways che promuovono la trasformazione del progenitore renale in cellula di origine del carcinoma renale papillare." Doctoral thesis, 2022. http://hdl.handle.net/2158/1263955.

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Questo studio ha dimostrato che il carcinoma renale papillare (pRCC), uno dei 3 più frequenti tipi di RCC, origina dall’espansione clonale di una popolazione di cellule staminali residenti nel rene, i progenitori renali . In seguito ad un danno renale acuto , queste cellule sono in grado di rigenerare la porzione di tubulo renale danneggiata. Tuttavia, in seguito al danno si ha l’alterazione di alcune pathways che possono promuovere la loro trasformazione in cellula staminale tumorale (CSC, cancer stem cell). In particolare, abbiamo dimostrato con questo lavoro di tesi che l’overespressione de
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Books on the topic "Renal progenitors"

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Pleniceanu, Oren, and Benjamin Dekel. Kidney stem cells. Edited by Adrian Woolf. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199592548.003.0344.

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End-stage renal failure is a major cause of death with currently only dialysis and transplantation available as therapeutic options, each with its own limitations and drawbacks. To allow regenerative medicine-based kidney replacement therapies and due to the fact that neither haematopoietic stem cells nor mesenchymal stem cells, the most accessible human stem cells, can be used to derive genuine nephron progenitors, much attention has been given to finding adult renal stem cells. Several candidates for this have been described, but their true identity as stem or progenitor cells and their pote
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Weinberger, Christopher. Imaginary Worlds and Real Ethics in Japanese Fiction. Bloomsbury Publishing Inc, 2024. http://dx.doi.org/10.5040/9798765105429.

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Can novels contribute to the ethical lives of readers? What responsibilities might they bear in representing others? Are we ethically accountable for how we read fiction? s study takes up modern Japanese fiction and metafiction, subjects overwhelmingly ignored by Anglophone scholarship on novel ethics, to discover pioneering answers to these and other questions. Each chapter offers new readings of major works of modern Japanese literature (1880s through 1920s) that experiment with the capacity of novel narration to involve readers in ethically freighted encounters. Christopher Weinberger shows
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Beitchman, Philip. Poverty of Philosophy. The Rowman & Littlefield Publishing Group, 2023. https://doi.org/10.5040/9780761875109.

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The Poverty of Philosophy: Readings in Non and Other Philosophies and Arts of Imminence kicks off with an 8,000 word overture, “Poverty of Philosophy” introducing non-philosophy and its progenitor, François Laruelle, his inspirations by, rapports and connections with other ‘philosophers of immanence’ (Nietzsche, Henry, Deleuze, Derrida...) as well as exploring, and also drawing some conclusions as to the possibilities of its present, and/or feasible impact on culture, politics and the arts, there follows the Anthology of NON, and other Philosophies and Arts of Immanence, comprised of some 300
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Book chapters on the topic "Renal progenitors"

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Zhang, Ping L., and Olaf Kroneman. "Evolving Understanding of Renal Progenitor (Stem) Cells in Renal Physiology and Pathophysiology." In Handbook of Stem Cell Applications. Springer Nature Singapore, 2023. http://dx.doi.org/10.1007/978-981-99-0846-2_23-1.

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Zhang, Ping L., and Olaf Kroneman. "Evolving Understanding of Renal Progenitor (Stem) Cells in Renal Physiology and Pathophysiology." In Handbook of Stem Cell Applications. Springer Nature Singapore, 2024. http://dx.doi.org/10.1007/978-981-99-7119-0_23.

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Sallustio, Fabio, Angela Picerno, Francesca Giannuzzi, Francesca Montenegro, Rossana Franzin, and Loreto Gesualdo. "The Regenerative Potential of Human Adult Renal Stem/Progenitor Cells." In Handbook of Stem Cell Applications. Springer Nature Singapore, 2023. http://dx.doi.org/10.1007/978-981-99-0846-2_24-1.

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Sallustio, Fabio, Angela Picerno, Francesca Giannuzzi, Francesca Montenegro, Rossana Franzin, and Loreto Gesualdo. "The Regenerative Potential of Human Adult Renal Stem/Progenitor Cells." In Handbook of Stem Cell Applications. Springer Nature Singapore, 2024. http://dx.doi.org/10.1007/978-981-99-7119-0_24.

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Bussolati, Benedetta, and Giovanni Camussi. "New Insights into the Renal Progenitor Cells and Kidney Diseases by Studying CD133." In Advances in Experimental Medicine and Biology. Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4614-5894-4_8.

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Minuth, Will W., and Lucia Denk. "Advanced Fixation for Transmission Electron Microscopy Unveils Special Extracellular Matrix Within the Renal Stem/Progenitor Cell Niche." In Methods in Molecular Biology. Springer New York, 2014. http://dx.doi.org/10.1007/7651_2014_93.

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Jacobi, Angela, Philipp Rosendahl, Martin Kräter, Marta Urbanska, Maik Herbig, and Jochen Guck. "Analysis of Biomechanical Properties of Hematopoietic Stem and Progenitor Cells Using Real-Time Fluorescence and Deformability Cytometry." In Stem Cell Mobilization. Springer New York, 2019. http://dx.doi.org/10.1007/978-1-4939-9574-5_11.

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Balistreri, Carmela Rita. "Endothelial Progenitor Cells: A Real Hope or an Unrealizable Dream? Which Measures or Strategies Are Necessary for making EPCs a clinical reality? Focus on a Potential Roadmap." In UNIPA Springer Series. Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-55107-4_3.

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Lasagni, Laura, Elena Lazzeri, Anna Peired, and Paola Romagnani. "Evidence for Renal Progenitors in the Human Kidney." In Kidney Development, Disease, Repair and Regeneration. Elsevier, 2016. http://dx.doi.org/10.1016/b978-0-12-800102-8.00029-1.

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Yamaleyeva, L. M., S. H. Mirmalek-Sani, A. Atala, and J. J. Yoo. "Renal progenitor and stem cell biology and therapy." In Progenitor and Stem Cell Technologies and Therapies. Elsevier, 2012. http://dx.doi.org/10.1533/9780857096074.3.443.

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Conference papers on the topic "Renal progenitors"

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Whited, Bryce M., Matthias C. Hofmann, Chris G. Rylander, et al. "Non-Destructive Real-Time Imaging of Cell Seeded Tissue Engineered Scaffolds." In ASME 2011 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2011. http://dx.doi.org/10.1115/sbc2011-53721.

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The use of tissue engineered scaffolds in combination with progenitor cells has emerged as a promising strategy to restore or replace tissues damaged by disease or trauma. In addition to being biocompatible and exhibiting appropriate mechanical properties, scaffolds must be designed to sustain cell attachment, proliferation, and differentiation to ultimately produce the desired tissue once implanted in the patient [1]. Conventional techniques used to assess successful scaffold design include cell viability stains, DNA assays, and histological sectioning/staining. While significant information
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Chechetka, Vladimir Vladimirovich. "Invention of the MP3 format as one of the most successful projects in the digital history of Germany." In All-Russian Scientific and Practical Conference, chair Aleksei Viacheslavovich Bredikhin. Publishing house Sreda, 2023. http://dx.doi.org/10.31483/r-108831.

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The creation of the famous format for storing and broadcasting audio data – mp3 solved at one time the problem of high-precision transmission of human speech via telephone lines. But soon a real revolution took place in the world of telecommunications – a fiber-optic cable and an ISDN digital communication network were created. The developers switched to another idea – efficient encoding and compression of audio signals. The scientist who first drew attention to the fact that optimal compression of audio content is impossible without taking into account the features of the human hearing aid wa
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Farace, Françoise, Marine Gross - Goupil, Elodie Tournay, Melissa Taylor, Catherine Hill, and Bernard Escudier. "Abstract 372: Circulating endothelial progenitor cell levels predict survival benefit in metastatic renal cell cancer patients treated with antiangiogenic agents." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-372.

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Medica, Davide, Vincenzo Cantaluppi, Rossana Franzin, et al. "Extracellular Vesicles derived from Endothelial Progenitor Cells inhibit complement- and cytokine-mediated injury of renal glomerular endothelial cells and podocytes." In Cell-to-Cell Metabolic Cross-Talk in Physiology and Pathology. MDPI, 2020. http://dx.doi.org/10.3390/cells2020-08932.

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Farace, Françoise, Claire Cropet, Ellen Blanc, David Pérol, Sylvie Négrier, and Bernard Escudier. "Abstract 4127: Levels of circulating CD45dimCD34+VEGFR2+ progenitor cells correlate with outcome in metastatic renal cell carcinoma patients treated with targeted therapies." In Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1538-7445.am2011-4127.

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MEIRELLES, KARINE PERES, and JOÃO GABRIEL TAVARES BRUNO. "PRINCIPAIS COMPLICAÇÕES CLÍNICAS CAUSADAS PELA HIPERTENSÃO ARTERIAL CRÔNICA NO PERÍODO GESTACIONAL." In I Congresso Brasileiro de Doenças Crônicas On-line. Revista Multidisciplinar em Saúde, 2022. http://dx.doi.org/10.51161/cronics/7535.

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Introdução: A Hipertensão Arterial é uma das condições médicas de maior incidência mundial, sendo responsável por cerca de 50 mil mortes maternas mundial por ano, e no Brasil, é considerada a primeira causa de mortalidade materna, correspondendo a 37% dos óbitos. Importante ressaltar, que para ser considerada crônica, deve ser diagnosticada até a 20ª semana gestacional e com pressão arterial sustentada  140 x 90 mmHg. Durante a gestação, quando não há o monitoramento e tratamento adequado da HAC, pode-se desencadear uma série de complicações clínicas graves que comprometem a manutenção da vit
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