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Dissertations / Theses on the topic 'Renal progenitors'

Author: Grafiati
Published: 10 March 2023
Last updated: 19 July 2025

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1

Hoshina, Azusa. "Development of new method to enrich human iPSC-derived renal progenitors using cell surface markers." Kyoto University, 2018. http://hdl.handle.net/2433/235064.

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Supplementary information 追加（2019-09-30)<br>Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(医学)<br>甲第21344号<br>医博第4402号<br>新制||医||1031(附属図書館)<br>京都大学大学院医学研究科医学専攻<br>(主査)教授 柳田 素子, 教授 山下 潤, 教授 江藤 浩之<br>学位規則第4条第1項該当
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2

Lund-Ricard, Yasmine. "Insights From The Small-Spotted Catshark : Kidney Development And The Persistence Of Renal Progenitor Cells In A Chondrichthyes Model." Electronic Thesis or Diss., Sorbonne université, 2023. http://www.theses.fr/2023SORUS130.

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Certains vertébrés peuvent régénérer des néphrons, l'unité fonctionnelle du rein. Cette capacité (la néonéphrogenèse) dépend de la présence de progéniteurs rénaux qui vont se différentier en les cellules du néphron. Pendant le développement des mammifères, les progéniteurs rénaux arrêtent de proliférer et se différencient autours de la naissance alors que d'autres vertébrés maintiennent leurs progéniteurs rénaux après le développement embryonnaire. Ainsi, après la perte de néphrons chez les mammifères, seule une réponse hypertrophique est observée. En contraste, la formation de novo de néphron
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3

Cañas, Solé Laura. "Determinació de cèl·lules progenitores endotelials, malaltia renal crònica i factors de risc cardiovascular." Doctoral thesis, Universitat Autònoma de Barcelona, 2016. http://hdl.handle.net/10803/399223.

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Introducció: La malaltia cardiovascular és la principal causa de mortalitat en els pacients amb malaltia renal crònica (MRC), tant en hemodiàlisi (HD) com en els pacients trasplantats renals. Els principals factors de risc cardiovascular dels pacients amb MRC,així com els factors de risc propis de la urèmia, produeixen disfunció endotelial en aquest grup de pacients. Aquesta disfunció endotelial incrementa la morbiditat cardiovascular en aquest grup de pacients. Les cèl.lules progenitores endotelials (CPE) són cèl·lules derivades del moll de l’os, presents en sang perifèrica i que tenen la c
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4

Zanusso, Ilenia. "Acellular matrices as tool for renal progenitor differentiation studies and tissue engineering of blood vessels." Doctoral thesis, Università degli studi di Padova, 2013. http://hdl.handle.net/11577/3423024.

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AMs seem to be a very promising scaffold in TE and can be considered as temporary inductive site-appropriate templates to support the growth, differentiation, and function of the parenchymal cell population of each organ. Nowadays, TE techniques are used both to develop tissue substitutes ex vivo and as reliable tool to investigate cell behaviour, differentiation and proliferation in 3-dimentional environments. In this work the following two different projects have investigated both potentialities using tissue-specific AMs: 1- influence of AMs on differentiation of kidney progenitor cells f
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5

Borges, Francielly Pinheiro da Silva. "Citomegalovírus em pacientes submetidos a transplante de células progenitoras hematopoiéticas." Universidade Federal de Goiás, 2016. http://repositorio.bc.ufg.br/tede/handle/tede/5801.

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Submitted by Luciana Ferreira (lucgeral@gmail.com) on 2016-08-03T12:26:28Z No. of bitstreams: 2 Dissertação - Francielly Pinheiro da Silva Borges - 2016.pdf: 3852166 bytes, checksum: 70bbe6c9a7c6c0aa1e10b9e7e9d49843 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)<br>Approved for entry into archive by Luciana Ferreira (lucgeral@gmail.com) on 2016-08-03T12:29:55Z (GMT) No. of bitstreams: 2 Dissertação - Francielly Pinheiro da Silva Borges - 2016.pdf: 3852166 bytes, checksum: 70bbe6c9a7c6c0aa1e10b9e7e9d49843 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e
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6

Chang, Claudia Veiga. "Análise de marcadores de células-tronco/progenitoras em hipófises de modelos animais com hipopituitarismo." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/5/5135/tde-03122013-115816/.

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Introdução: As células-tronco apresentam capacidade de proliferação, autorrenovação, potencial de diferenciação e já foram descritas na hipófise estando envolvidas na renovação celular e regulação homeostática, porém pouco se sabe sobre o seu perfil de expressão nos quadros de hipopituitarismo. Dentre os marcadores de células-tronco descritos previamente na hipófise, destacam-se os genes Sox2, Nanog, Nestina, Cd44 e Oct4. Outro marcador, o gene Nr2e1 (Tlx), encontrado em células-tronco neuronais, apresenta-se elevado durante a embriogênese e na vida adulta no cérebro de camundongos, mas, até o
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7

Jian, Motamedi Fariba. "Les fonctions vitales de WT1 au cours de la vie des cellules progénitrices du rein embryonnaire." Thesis, Nice, 2015. http://www.theses.fr/2015NICE4099.

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Le développement du rein est un exemple intriguant d’un équilibre délicat entre la prolifération des cellules progénitrices, la différentiation et l’apoptose. Le gène Wt1 est indispensable pour la survie des cellules progénitrices. Le but de cette thèse a été de définir les voies de signalisation activées par Wt1 pendant le développement du rein. En utilisant les souris Wt1 KO, nous avons démontré que WT1 coordonne l’action de deux voies de signalisation opposées : Fgf et Bmp/Smad intervenant dans la survie des cellules progénitrices rénales. Dans une deuxième étude, nous avons analysé le rôle
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8

Jian, Motamedi Fariba. "Les fonctions vitales de WT1 au cours de la vie des cellules progénitrices du rein embryonnaire." Electronic Thesis or Diss., Nice, 2015. http://www.theses.fr/2015NICE4099.

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Le développement du rein est un exemple intriguant d’un équilibre délicat entre la prolifération des cellules progénitrices, la différentiation et l’apoptose. Le gène Wt1 est indispensable pour la survie des cellules progénitrices. Le but de cette thèse a été de définir les voies de signalisation activées par Wt1 pendant le développement du rein. En utilisant les souris Wt1 KO, nous avons démontré que WT1 coordonne l’action de deux voies de signalisation opposées : Fgf et Bmp/Smad intervenant dans la survie des cellules progénitrices rénales. Dans une deuxième étude, nous avons analysé le rôle
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9

NARDI, SARA. "Studio dell'effetto di un danno renale acuto sulla formazione di carcinoma renale." Doctoral thesis, 2019. http://hdl.handle.net/2158/1154908.

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Lo studio affrontato in questa tesi ha evidenziato come il danno renale acuto possa influire sullo sviluppo di carcinoma renale, e in particolare delle forme papillari di carcinoma, agendo sulla via di segnalazione di Notch. Abbiamo preso in considerazione una popolazione di progenitori renali localizzati tra le cellule epiteliali parietali (PEC) e le cellule epiteliali tubulari (TEC), la cui proliferazione e differenziazione è controllata dalla via di segnalazione di Notch. Abbiamo lavorato in vivo allestendo linee murine transgeniche in cui i progenitori renali sono identificati dal marcato
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10

Antonelli, Giulia. "Studio delle pathways che promuovono la trasformazione del progenitore renale in cellula di origine del carcinoma renale papillare." Doctoral thesis, 2022. http://hdl.handle.net/2158/1263955.

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Questo studio ha dimostrato che il carcinoma renale papillare (pRCC), uno dei 3 più frequenti tipi di RCC, origina dall’espansione clonale di una popolazione di cellule staminali residenti nel rene, i progenitori renali . In seguito ad un danno renale acuto , queste cellule sono in grado di rigenerare la porzione di tubulo renale danneggiata. Tuttavia, in seguito al danno si ha l’alterazione di alcune pathways che possono promuovere la loro trasformazione in cellula staminale tumorale (CSC, cancer stem cell). In particolare, abbiamo dimostrato con questo lavoro di tesi che l’overespressione de
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11

Conte, Carolina. "Studio del ruolo dei progenitori renali nell’eziopatogenesi della preeclampsia." Doctoral thesis, 2022. http://hdl.handle.net/2158/1263956.

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I progenitori renali hanno un ruolo di primaria importanza nella capacità del rene di far fronte allo stress da filtrazione glomerulare e di ripristinare prontamente i podociti danneggiati durante la gravidanza. La stimolazione estrogenica guida tale adattamento e se carente può fare la differenza tra il successo della gravidanza e l’insorgenza di complicanze quali la preeclampsia. Questi risultati aggiungono un tassello in più verso l a comprensione dell’eziopatogenesi della preeclampsia, in quanto pongono il rene, in particolare la capacità dei progenitori renali di generare nuovi podociti,
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12

LOMBARDI, DUCCIO. "Ruolo della popolazione di progenitori tubulari Pax2+ nella rigenerazione del tubulo renale dopo insufficienza renale acuta." Doctoral thesis, 2016. http://hdl.handle.net/2158/1020975.

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Evaluation of tubular regenerative response in AKI-induced trasngenic rodent models. Discovered the existence of a progenitor population scattered in kidney tubule of adut mice devoted to tubular epithelium recovery after ischemic injury.
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13

SAGRINATI, COSTANZA. "Potenzialità rigenerative dei progenitori embrionali renalimultipotenti CD24+CD133+ in un modello di insufficienzarenale acuta." Doctoral thesis, 2008. http://hdl.handle.net/2158/599077.

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14

Po-TsangLee and 李柏蒼. "Progenitor Cells Derived from Adult Mouse Kidney Mesenchyme Accelerate Renal Regeneration after Ischemic Injury." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/12617859242552339537.

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博士<br>國立成功大學<br>臨床醫學研究所<br>98<br>In Taiwan, the incidence of end-stage renal disease ranked first and the prevalence ranked second in the world. Patients with end-stage renal disease need hemodialysis, peritoneal dialysis or kidney transplant to maintain their life. For the shortage of available organ, most of the patients are under regular dialysis. To accelerate renal repair or even make a functioning kidney is the emergent issue to be solved and interesting topic for research. Following the discovery of tissue-specific progenitor cells in other organs and their ability to improve regenerati
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15

Almeida, Ana Rita Sobreiro. "New strategies envisioning functional recovery of the injured kidney." Doctoral thesis, 2021. http://hdl.handle.net/1822/75124.

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Tese de Doutoramento em Engenharia de Tecidos, Medicina Regenerativa e Células Estaminais<br>Kidney diseases represent a major healthcare burden worldwide. It is estimated that one in ten persons suffer from kidney dysfunction. Indeed, a decline in renal function is considered an independent risk factor for both cardiovascular disease and all-cause mortality. The problem is only aggravated by treatment alternatives, with dialysis and transplantation being the only currently available renal replacement therapies. Envisioning the functional recovery of the injured kidney, two regenerat
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16

Poletto, Valentina. "Circulating Endothelial Progenitor Cells from a patients with renal cell carcinoma display aberrant VEGF regulation, reduced apoptosis and altered ultrastructure." Tesi di dottorato, 2015. http://www.fedoa.unina.it/10236/1/poletto_valentina_27.pdf.

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Angiogenesis is a fundamental biological process during development as well as in adult life, both in physiological and pathological conditions, as for example in cancer development. Endothelial Progenitor Cells (EPCs) are cells with self-renewal capacity, able to differentiate into mature Endothelial Cells (ECs) and to generate patent vessels in vivo. EPCs seem to play a fundamental role in the "angiogenic switch", the process which allows the transition from in situ carcinoma to a highly vascularized tumor; therefore, they could be a potential target in the development of new drugs. In our w
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17

Hildebrandt, Axel. "Der Einfluss von Melatonin auf den nephroprotektiven Effekt von Endothelprogenitorzellen im Mausmodell." Doctoral thesis, 2012. http://hdl.handle.net/11858/00-1735-0000-000D-F000-9.

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18

Bonss, Martina Rita Monika. "Analyse organoprotektiver Effekte der renalen Denervation zur Behandlung therapierefraktärer arterieller Hypertonie." Doctoral thesis, 2019. http://hdl.handle.net/11858/00-1735-0000-002E-E600-4.

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