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Journal articles on the topic 'Renal Prognosi'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Silva, G. E. B., R. S. Costa, R. C. Ravinal, M. A. dos Reis, M. Dantas та T. M. Coimbra. "Mast Cells, TGF-β1 andα-SMA Expression in IgA Nephropathy". Disease Markers 24, № 3 (2008): 181–90. http://dx.doi.org/10.1155/2008/725408.

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IgA nephropathy (IgAN) is a kidney disease with a varying renal prognosis. Recently, many studies have demonstrated that renalα-smooth muscle actin (α-SMA) and transforming growth factor (TGF-β1) expression, as well interstitial mast cell infiltrates could represent a prognostic marker in several renal diseases. The aim of our study was to analyze the prognostic value of mast cell, TGF-β1 andα-SMA expression in IgAN. A survey of the medical records and renal biopsy reports of 62 patients with a diagnosis of IgAN followed-up from 1987 to 2003 was performed. The mean follow-up time was 74.7±50.0

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Ye, Dayong, Jingxian Luo, Yujie Wang, Mingqiang Su, Dayong Zhang, and Dengjun Han. "Prognostic Value and Clinical Significance of Vesicular Transport-Related Genes in Clear Cell Renal Cell Carcinoma." Kidney and Blood Pressure Research 49, no. 1 (2024): 410–29. http://dx.doi.org/10.1159/000539095.

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Introduction: Vesicular transport (VT) has a complex relationship with tumor progression and immunity. But prognostic significance of VT in clear cell renal cell carcinoma (ccRCC) is unclear. Thus, we aimed to establish a prognostic model according to VT to predict overall survival of ccRCC patients. Methods: We used patient data from TCGA database and built a prognostic model with 13 VT-related genes (VTRGs) by differential expression analysis, LASSO regression, and univariate/multivariate Cox analysis. The model was validated internally and externally, and survival analysis and ROC curves de

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Pierscianek, Daniela, Marvin Darkwah Oppong, Yahya Ahmadipour, et al. "Electrolyte and renal disorders in patients with newly diagnosed glioblastoma." Future Oncology 17, no. 34 (2021): 4711–19. http://dx.doi.org/10.2217/fon-2020-1312.

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Purpose: Disturbances of electrolytes and renal function have been linked to the prognosis of critically ill patients and recently also of cancer patients. This study aimed to assess electrolyte and renal disorders in glioblastoma patients and evaluate their prognostic effect. Methods: Medical records of patients with newly diagnosed glioblastoma between 2005 and 2018 were retrospectively reviewed for electrolyte and renal function parameters and for demographic, clinical and outcome parameters. Results: Electrolyte and renal function disorders were associated with poorer survival in univariat

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4

Kalowes, Peggy. "Improving End-of-Life Care Prognostic Discussions." AACN Advanced Critical Care 26, no. 2 (2015): 151–66. http://dx.doi.org/10.4037/nci.0000000000000086.

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Research has validated the desire of patients and families for ongoing prognostic information; however, few conversations occur before patients reach the advanced stages of their disease trajectory. Physician hesitance and delay in discussing unfavorable prognoses deny patients and families optimal time to prepare for critical decision making. Advanced practice registered nurses can play a crucial, complementary role with the critical care interdisciplinary team to implement strategies to improve communication about prognosis and end of life with patients and families. Clinicians should discus

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Peng, Xiqi, Xiang Pan, Kaihao Liu, et al. "miR-142-3p as a novel biomarker for predicting poor prognosis in renal cell carcinoma patients after surgery." International Journal of Biological Markers 34, no. 3 (2019): 302–8. http://dx.doi.org/10.1177/1724600819866456.

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Background: miR-142-3p has proved to be involved in tumorigenesis and the development of renal cell carcinoma. The present study aimed to explore the prognostic value of miR-142-3p. Methods: Total RNA was extracted from renal cell carcinoma specimens and the expression level of miR-142-3p was measured. Pearson Chi-square test, Kaplan–Meier analysis, as well as univariate and multivariate regression analysis were performed to determine the correlation between miR-142-3p and the prognosis of renal cell carcinoma patients. Receiver operating characteristic curves were constructed to evaluate the

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T J, Dr Cicily. "Aetiology and Prognosis in Pregnancy Related Acute Renal Failure." Journal of Medical Science And clinical Research 05, no. 03 (2016): 19299–305. http://dx.doi.org/10.18535/jmscr/v5i3.155.

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Li, Xinxin, Qihui Kuang, Min Peng, Kang Yang, and Pengcheng Luo. "Basement Membrane-Associated lncRNA Risk Model Predicts Prognosis and Guides Clinical Treatment in Clear Cell Renal Cell Carcinoma." Biomedicines 11, no. 10 (2023): 2635. http://dx.doi.org/10.3390/biomedicines11102635.

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The basement membrane (BM) affects the invasion and growth of malignant tumors. The role and mechanism of BM-associated lncRNAs in clear cell renal cell carcinoma (ccRCC) are unknown. In this study, we identified biomarkers of ccRCC and developed a risk model to assess patient prognosis. We downloaded transcripts and clinical data from the Cancer Genome Atlas (TCGA). Differential analysis, co-expression analysis, Cox regression analysis, and lasso regression were used to identify BM-associated prognostic lncRNAs and create a risk prediction model. We evaluated and validated the accuracy of the

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Jiang, Aimin, Yewei Bao, Anbang Wang, et al. "Establishment of a Prognostic Prediction and Drug Selection Model for Patients with Clear Cell Renal Cell Carcinoma by Multiomics Data Analysis." Oxidative Medicine and Cellular Longevity 2022 (January 4, 2022): 1–30. http://dx.doi.org/10.1155/2022/3617775.

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Rationale. Patients with clear cell renal cell cancer (ccRCC) may have completely different treatment choices and prognoses due to the wide range of heterogeneity of the disease. However, there is a lack of effective models for risk stratification, treatment decision-making, and prognostic prediction of renal cancer patients. The aim of the present study was to establish a model to stratify ccRCC patients in terms of prognostic prediction and drug selection based on multiomics data analysis. Methods. This study was based on the multiomics data (including mRNA, lncRNA, miRNA, methylation, and W

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Schiavone, D., A. Isgrò, F. Migliorini, et al. "Prognostic value of clinical parameters for renal cell carcinoma." Urologia Journal 64, no. 2 (1997): 156–64. http://dx.doi.org/10.1177/039156039706400202.

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– Clinical evaluation of patients with kidney tumours should provide several parameters with possible prognostic value, such as age, sex, incidental discovery, duration of symptoms, weight loss, fever, disease-free interval, performance status, elevated ESR, hypercalcemia, elevated gamma-enolase, local tumour extension, invasion of renal vein and inferior vena cava, lymphatic metastases, distant metastases, tumour dimension, multicentricity, bilaterality and growth velocity. Some of these factors correlate to prognosis in univariate statistical analysis; in multivariate analysis, however, tumo

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Hatakeyama, Shingo, Hiromi Murasawa, Itsuto Hamano, et al. "Prognosis of Elderly Japanese Patients Aged ≥80 Years Undergoing Hemodialysis." Scientific World Journal 2013 (2013): 1–7. http://dx.doi.org/10.1155/2013/693514.

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Although the number of elderly patients requiring dialysis has increased, data regarding the prognosis of elderly patients undergoing hemodialysis are limited. In the present study, prognosis in Japanese hemodialysis patients aged ≥80 years was evaluated. From January 1988 to July 2013, 1144 consecutive patients with end-stage renal disease required renal replacement therapy at our institution; of these, 141 were aged ≥80 years. These patients’ charts were retrospectively reviewed for relevant clinical variables and survival time. The life expectancies table from the National Vital Statistics

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Wu, Guangzhen, Jianyi Li, Yingkun Xu, Xiangyu Che, Feng Chen, and Qifei Wang. "A New Survival Model Based on ADAMTSs for Prognostic Prediction in Clear Cell Renal Cell Carcinoma." Journal of Oncology 2021 (September 23, 2021): 1–10. http://dx.doi.org/10.1155/2021/2606213.

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The main purpose of this study was to explore the genetic variation, gene expression, and clinical significance of ADAMTSs (a disintegrin and metalloprotease domains with thrombospondin motifs) across cancer types. Analysis of data from the TCGA (The Cancer Genome Atlas) database showed that the ADAMTSs have extensive CNV (copy number variation) and SNV (single nucleotide variation) across cancer types. Compared with normal tissues, the methylation of ADAMTSs in cancer tissues is also significantly different, which affects the expression of ADAMTS gene and the prognosis of cancer patients. Thr

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UZUN, Mehmet, Eda ÇALIŞKAN YILDIRIM, Hüseyin Salih SEMİZ, et al. "Examination of Factors Affecting General Survival in Patients with Metastatic Renal Cell Cancer: A Case of Dokuz Eylül University Medical Oncology Clinic." Medical Journal of Western Black Sea 6, no. 2 (2022): 165–71. http://dx.doi.org/10.29058/mjwbs.1084889.

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Aim: Despite many new generation treatments, it is known that the prognostic markers used to date in patients with metastatic renal cell carcinoma (mRCC), who have a very poor prognosis, can not accurately determine the prognosis in every patient. Therefore, the search for prognostic biomarkers continues. In this study, it was aimed to investigate the effect of pre-treatment biochemical parameters on oncological outcomes in mRHC patients. Material and Methods: We retrospectively evaluated the clinical, pathological, survival characteristics and factors affecting survival of 9

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Kwon, Se Yun, Jun Nyung Lee, Bum Soo Kim, et al. "Impact of Microvascular Invasion and Tumor Necrosis on the Prognosis of Korean Patients with pT1b Renal Cell Carcinoma." Urologia Internationalis 95, no. 1 (2014): 65–71. http://dx.doi.org/10.1159/000366138.

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Objectives: To evaluate prognostic factors in pT1b renal cell carcinoma (RCC) patients for which no specific studies have been conducted on. Methods: The data of 270 patients diagnosed with pT1bN0M0 RCC at 2 institutions between January 1998 and June 2010 were retrospectively analyzed. Univariate and multivariate analyses using Cox proportional hazard models were used to identify pathologic and clinical factors that influenced prognosis. Five-year recurrence-free survival and cancer-specific survival were analyzed using the Kaplan-Meier method. Results: The median follow-up period was 55.5 mon

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Liu, Feng, Chenyu Wang, Rongzhen Wang, Wenge Wang, and Min Li. "Henoch-schonlein purpura nephritis with renal interstitial lesions." Open Medicine 13, no. 1 (2018): 597–604. http://dx.doi.org/10.1515/med-2018-0088.

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AbstractObjectiveTo investigate the clinical pathology and prognosis & outcome of Henoch-Schonlein purpura nephritis (HSPN) with renal interstitial lesions.MethodsAll 148 patients were analyzed for clinical, renal pathological, and prognostic features. Patients with no, mild, and moderate- severe renal tubulo-interstitial lesions were included in group A, B and C, respectively.ResultsThe estimated glomerular filtration rate (eGFR) of group B was significantly lower than that of group A. The levels of serum creatinine and blood urea nitrogen in group C were significantly higher than those i

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Abdel-Qadir, Husam M., Shaan Chugh, and Douglas S. Lee. "Improving Prognosis Estimation in Patients with Heart Failure and the Cardiorenal Syndrome." International Journal of Nephrology 2011 (2011): 1–11. http://dx.doi.org/10.4061/2011/351672.

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The coexistence of heart failure and renal dysfunction constitutes the “cardiorenal syndrome” which is increasingly recognized as a marker of poor prognosis. Patients with cardiorenal dysfunction constitute a large and heterogeneous group where individuals can have markedly different outcomes and disease courses. Thus, the determination of prognosis in this high risk group of patients may pose challenges for clinicians and for researchers alike. In this paper, we discuss the cardiorenal syndrome as it pertains to the patient with heart failure and considerations for further refining prognosis

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Silva, Rafaela V. N., Lucas A. Berzotti, Marcella G. Laia, et al. "Implications of MTHFD2 expression in renal cell carcinoma aggressiveness." PLOS ONE 19, no. 2 (2024): e0299353. http://dx.doi.org/10.1371/journal.pone.0299353.

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Renal cell carcinoma (RCC) is the most common type of cancer in kidney and is often diagnosed in advanced stages. Until now, there is no reliable biomarker to assess tumor prognosis during histopathological diagnosis. The Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) overexpression has been suggested as prognostic indicator for RCC, however, its protein profile needs to be clarified. This study investigated the MTHFD2 expression in different RCC cohorts, associating it with tumor characteristics and prognostic factors. Gene expression comparisons between non-neoplastic (NN) and tumor samp

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Semenov, Dmitry. "The Influence of Prognostic Predictors on Survival Rates in Patients with Synchronous Metastases of Renal Cell Cancer in the Lungs." Oncology.kz 1, no. 11 (2024): 4–11. https://doi.org/10.56598/2957-6377-2024-1-11-4-11.

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A personalized approach to the management of patients with synchronous lung metastases of renal cell cancer (RCC) is an important aspect of comprehensive treatment.The aim of the study was to investigate prognostic factors in patients with synchronous metastases (SM) of RCC.Methods. We retrospectively analyzed the data of 273 patients with synchronous pulmonary metastases of PCR treated at the Moscow City Oncologic Hospital No. 62 in Moscow and the City Clinical Oncologic Dispensary (St. Petersburg) from 2006 to 2022. The study investigated clinical and morphologic prognostic factors influenci

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Zhai, Yaling, Xingchen Yao, Yuanyuan Qi, et al. "Elevated Serum Chloride Levels Contribute to a Poor Prognosis in Patients with IgA Nephropathy." Journal of Immunology Research 2021 (October 8, 2021): 1–9. http://dx.doi.org/10.1155/2021/3598135.

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Introduction. The identification of reliable prognostic factors is a crucial requirement for patients with IgA nephropathy (IgAN). Here, we explored the relationship between serum chloride levels and prognosis in patients with IgAN. Methods. We recruited all patients with primary IgAN, as diagnosed by renal biopsy, between 1st January 2015 and 1st April 2019. Patients were divided two groups (high chloride group and low chloride group) based on the best cut-off values from survival receiver operating characteristic (ROC) curves. The baseline clinicopathological characteristics of two groups we

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Kusdjianto, Amanda Yuanita. "The Role of Critical Laboratory Parameters to Determine the Severity and Prognosis of COVID-19: Systematic Review." Cermin Dunia Kedokteran 49, no. 10 (2022): 585–88. http://dx.doi.org/10.55175/cdk.v49i10.311.

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Introduction: Few studies have addressed the diagnostic and prognostic value of abnormal laboratory findings in COVID-19 patients. Objective: To identify and assess published studies on the role of laboratory parameters to determine the severity of COVID-19 patients. Method: Systematic review of articles identified from NCBI, Pubmed, BMC, and Elsevier from 2020-2022. Results: Laboratory parameters: complete blood count, serum electrolyte, renal function, liver function, pancreatic enzymes, D-dimer, inflammatory cytokines, and C-reactive protein have a diagnostic and prognostic value in determi

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Muriel, C., E. Esteban, A. Astudillo, et al. "Prognostic factors in patients with advanced renal carcinoma." Journal of Clinical Oncology 29, no. 7_suppl (2011): 391. http://dx.doi.org/10.1200/jco.2011.29.7_suppl.391.

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391 Background: A retrospective cohort of 135 patients with advanced RCC treated with biological agents and/or cytokines (CK) was analysed between July 1996 and February 2010. Methods: The expression of several biomarkers by immunohistochemistry and 2 analytical variables: thrombocytosis and neutrophilia were analysed and were correlated with prognosis. Results: 67 patients were treated only with biological agents and 68 with CK (23 received also biological agents). The univariate statistical analysis showed that the enhanced expression of HIF-1alpha correlated with a poor prognosis in patient

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TOGUCHI, MASAFUMI, KOUSEI ISHIGAMI, MASATO GOYA, SEIICHI SAITO, SADAYUKI MURAYAMA, and AKIHIRO NISHIE. "Efficacy of Pre-operative 18F-FDG PET/CT in Prognostic Prediction in Patients With Renal Cell Carcinoma." Cancer Diagnosis & Prognosis 2, no. 2 (2022): 216–22. http://dx.doi.org/10.21873/cdp.10097.

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Background/Aim: This study analyzed the parameters provided by preoperative 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) for prognostic prediction of renal cell carcinoma (RCC). Patients and Methods: FDG-PET/CT data from 66 clear cell RCC and 19 non-clear cell RCC cases between January 2015 and October 2018 were reviewed retrospectively. We compared the two groups according to recurrence/metastasis to determine prognosis-influencing factors. Multivariate Cox hazard regression models were constructed to evaluate factors potentially predicting disease-free

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Pourmohammadi, Nadia, Azadeh Khayyat, Mohammad Ali Esmaeil Pour, Maryam Ghasemi, and Parisa Kaviani. "Elderly versus young IgA nephropathy; an update on current data." Journal of Nephropathology 13, no. 4 (2024): e25552. http://dx.doi.org/10.34172/jnp.2024.25552.

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IgA nephropathy (IgAN) is a common glomerular disease affecting individuals across the age spectrum. However, there are differences in the presentation and prognosis of IgAN between elderly and young adults. Elderly patients with IgAN tend to present with more severe kidney disturbances, worse baseline renal function, and a poorer prognosis compared to young adults. The Oxford classification contributes to the overall prognosis of IgAN in elderly patients by improving prognostic assessment, providing a better determinant of kidney survival, and combining histopathologic findings with clinical

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Ganesan, Sarumathy, Prathiba Arumugam, Nithya Ilanchezhian, and Saraswathi Manickam. "Evaluation of Ki67 Expression in Relation to Tumor Stage and Fuhrman Nuclear Grade of Renal Cell Carcinoma and MUC1 Expression in Clear Cell Renal Cell Carcinoma." Journal of Evolution of Medical and Dental Sciences 10, no. 33 (2021): 2718–22. http://dx.doi.org/10.14260/jemds/2021/555.

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BACKGROUND Renal cell carcinoma (RCC) is the most common malignant renal tumour in adults. Prognosis of RCC depends on various factors like tumour stage, nuclear grade and histological type. For planning adjuvant therapy, accurate prediction of prognosis is mandatory. In many studies, ki67 and MUC1 has shown to be of prognostic significance and immunohistochemical expression of these two markers plays an important role in determining the prognosis of RCC. The purpose of this study was to evaluate the Ki67 expression in histologically confirmed cases of RCC and MUC1 expression in clear cell ren

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Permi, Harish S. "RENAL CELL CARCINOMA WITH OSSEOUS METAPLASIA OCCURRING IN A CONTRACTED KIDNEY - A RARE CASE REPORT." Journal of Health and Allied Sciences NU 03, no. 04 (2013): 137–38. http://dx.doi.org/10.1055/s-0040-1703721.

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AbstractOsseous metaplasia is a rare histologic feature associated with renal cell carcinoma, occurring in a contracted kidney is still rarer. Metaplastic bone formation within the renal tumor gives an appearance similar to that of calcification. It is difficult to distinguish between bone formation and calcification on the basis of radiological imaging alone. Prognostic significance of metaplastic bone formation in renal cell carcinoma is not clear, however some report suggest good prognosis as a result of limitation of tumor spread by bone formation. This case report highlights the occurrenc

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Hanamura, Kikuno, Akihiro Tojo, Satoshi Kinugasa, Kensuke Asaba, and Toshiro Fujita. "The Resistive Index Is a Marker of Renal Function, Pathology, Prognosis, and Responsiveness to Steroid Therapy in Chronic Kidney Disease Patients." International Journal of Nephrology 2012 (2012): 1–9. http://dx.doi.org/10.1155/2012/139565.

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To evaluate the significance of the renal resistive index (RI) as a noninvasive marker of renal histological damage and a prognostic indicator, we examined RI by Doppler ultrasonography in 202 chronic kidney disease (CKD) patients who underwent renal biopsy. RI increased as the CKD stage progressed and correlated with age, systolic blood pressure, estimated glomerular filtration rate (eGFR), and renal histological changes, including glomerulosclerosis, arteriolosclerosis, and tubulointerstitial damage. Prognostic evaluation with a median follow-up period of 38.5 months revealed that patients w

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Fan, Zhiyi, Zhangheng Huang, and Xiaohui Huang. "Bone Metastasis in Renal Cell Carcinoma Patients: Risk and Prognostic Factors and Nomograms." Journal of Oncology 2021 (May 12, 2021): 1–17. http://dx.doi.org/10.1155/2021/5575295.

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Background. Bone metastasis (BM) is one of the common sites of renal cell carcinoma (RCC), and patients with BM have a poorer prognosis. We aimed to develop two nomograms to quantify the risk of BM and predict the prognosis of RCC patients with BM. Methods. We reviewed patients with diagnosed RCC with BM in the Surveillance, Epidemiology, and End Results (SEER) database from 2010 to 2015. Multivariate logistic regression analysis was used to determine independent factors to predict BM in RCC patients. Univariate and multivariate Cox proportional hazards regression analyses were used to determi

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Li, Fan, Weifeng Hu, Wei Zhang, Guohao Li, and Yonglian Guo. "A 17-Gene Signature Predicted Prognosis in Renal Cell Carcinoma." Disease Markers 2020 (February 27, 2020): 1–9. http://dx.doi.org/10.1155/2020/8352809.

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Renal cell carcinoma (RCC), which was one of the most common malignant tumors in urinary system, had gradually increased incidence and mortality in recent years. Although significant advances had been made in molecular and biology research on the pathogenesis of RCC, effective treatments and prognostic indicators were still lacking. In order to predict the prognosis of RCC better, we identified 17 genes that were associated with the overall survival (OS) of RCC patients from The Cancer Genome Atlas (TCGA) dataset and a 17-gene signature was developed. Through SurvExpress, we analyzed the expre

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Kanomata, Naoki, Yasufumi Sato, Yoshiyuki Miyaji, Atsushi Nagai, and Takuya Moriya. "Vasohibin-1 is a new predictor of disease-free survival in operated patients with renal cell carcinoma." Journal of Clinical Pathology 66, no. 7 (2013): 613–19. http://dx.doi.org/10.1136/jclinpath-2013-201444.

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BackgroundVasohibin-1 (VASH1) is an endothelium-produced angiogenesis inhibitor. Renal cell carcinoma is highly vascularised, but the significance of endogenous VASH1 in renal cell carcinoma has not been defined.AimsTo identify VASH1 expression and its possible relationship with various clinicopathological factors and prognosis in renal cell carcinoma.MethodsA retrospective analysis of 122 tumours obtained from 118 consecutive patients with renal cell carcinoma was performed. The expression patterns of VASH1, CD31, vascular endothelial growth factor (VEGF) and VEGF receptor type 2 (VEGFR2) wer

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Zoshima, T., S. Hara, and M. Kawano. "FRI0188 THE CLINICOPATHOLOGICAL SIGNIFICANCE OF MODIFIED NATIONAL INSTITUTES OF HEALTH ACTIVITY AND CHRONICITY SCORING SYSTEM IN LUPUS NEPHRITIS; A MULTICENTER RETROSPECTIVE STUDY." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 677.2–678. http://dx.doi.org/10.1136/annrheumdis-2020-eular.3016.

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Background:The revised International Society of Nephrology/Renal Pathology Society (ISN/RPS) Classification of lupus nephritis (LN) 2018 defined a modified National Institutes of Health activity and chronicity scoring system for all LN classes [1]. As this was not arrived at by an evidence-based approach, its clinicopathological significance including prognostic value should be validated [1]. Furthermore, though the activity index included wire-loop lesion and hyaline deposits (WL), we previously demonstrated that WL was associated with serological immune abnormality, but not renal prognosis [

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Wu, JianPing, QianXia Wu, MinYi Wu, and WeiLin Mao. "Serum Cystatin C Predicts Mortality in HBV-Related Decompensated Cirrhosis." BioMed Research International 2019 (March 4, 2019): 1–6. http://dx.doi.org/10.1155/2019/7272045.

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Background. Some studies have reported that renal dysfunction is associated with poor prognosis in cirrhotic patients. Serum cystatin C (CysC) is an accurate biomarker for early renal dysfunction. This study aimed to assess the prognostic value of serum CysC levels in patients with hepatitis B virus-related decompensated cirrhosis (HBV-DeCi). Methods. This retrospective study included 75 subjects who had been diagnosed with HBV-DeCi. The association between serum CysC and prognosis was estimated by receiver operating characteristic curve analysis and a multivariable logistic regression model.

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Suto, Hironobu, Takuro Fuke, Hiroyuki Matsukawa, et al. "Short- and Long-Term Outcomes of Neoadjuvant Chemoradiotherapy Followed by Pancreatoduodenectomy in Elderly Patients with Resectable and Borderline Resectable Pancreatic Cancer: A Retrospective Study." Journal of Clinical Medicine 13, no. 5 (2024): 1216. http://dx.doi.org/10.3390/jcm13051216.

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Background: The efficacy of neoadjuvant chemoradiotherapy (NACRT) followed by pancreatoduodenectomy (PD) in elderly patients with pancreatic ductal adenocarcinoma (PDAC) remains unclear. Methods: This retrospective analysis of prospectively collected data examined the effect of NACRT followed by PD in elderly patients with PDAC. A total of 112 patients with resectable (R-) and borderline resectable (BR-) PDAC, who were planned for PD and received NACRT between 2009 and 2022, were assessed. Changes induced by NACRT, surgical outcomes, nutritional status, renal and endocrine functions, and progn

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Nam, J., C. Park, and T. Kim. "UP-03.152 Prognosis and Prognostic Factors in Renal Pelvis and Ureter Tumors." Urology 78, no. 3 (2011): S394. http://dx.doi.org/10.1016/j.urology.2011.07.1241.

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Gao, Yiren, and Zhen Jia. "Prognosis Signature of Cuprotosis-Related lncRNAs Associated with Kidney Renal Clear Cell Carcinoma." Genetics Research 2022 (November 17, 2022): 1–11. http://dx.doi.org/10.1155/2022/6004852.

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Cuprotosis is a novel cell death mechanism that can be explored to treat various tumors. A few studies on the role of cuprotosis-related long noncoding RNA (lncRNA) in the development and prognosis of kidney renal clear cell carcinoma (KIRC) have been reported. We aimed to study the relationship between the prognosis of patients suffering from KIRC and lncRNAs associated with cuprotosis. The Cancer Genome Atlas (TCGA) database was analyzed, and the transcriptome data and clinical information on the patients with KIRC were obtained. The cuprotosis-related lncRNAs were identified by using Pearso

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Kovaleva, O. V., A. N. Gratchev, E. I. Makarova, et al. "Prognostic significance of sPD-1/sPD-L1 in renal cancer depending on the phenotype of tumor and stromal cells." Cancer Urology 18, no. 2 (2022): 17–28. http://dx.doi.org/10.17650/1726-9776-2022-18-2-17-28.

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Background. The search for new prognostic markers of renal cell carcinoma is an urgent problem of oncourology. Modern studies demonstrate the need for a comprehensive assessment of the clinical and prognostic significance of many markers.Aim is a comprehensive analysis of the prognostic significance of soluble forms of PD-1 and PD-L1 (sPD-1 and sPD-L1) depending on the phenotype of tumor cells and the microenvironment.Materials and methods. The study included tumor tissue and serum samples from 54 patients with renal cell cancer and from 67 healthy donors. The concentrations of sPD-1 and sPD-L

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Horinouchi, Tomoko, Tomohiko Yamamura, China Nagano, et al. "Heterozygous Urinary Abnormality–Causing Variants of COL4A3 and COL4A4 Affect Severity of Autosomal Recessive Alport Syndrome." Kidney360 1, no. 9 (2020): 936–42. http://dx.doi.org/10.34067/kid.0000372019.

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BackgroundAutosomal recessive Alport syndrome (ARAS) is an inherited renal disorder caused by homozygous and compound heterozygous mutations in COL4A3 or COL4A4, but the prognostic predictors for this disorder are not yet fully understood. Recently, the magnitude of the clinical spectrum of the COL4A3 and COL4A4 heterozygous state has attracted attention. This spectrum includes asymptomatic carriers of ARAS, benign familial hematuria, thin basement membrane disease, and autosomal dominant Alport syndrome.MethodsWe retrospectively analyzed 49 patients with ARAS from 41 families with a median ag

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Hong, Green, Da Hyun Kang, Sunghoon Park, et al. "Clinical Characteristics and Prognosis of Older Patients with Coronavirus Disease 2019 Requiring Mechanical Ventilation." Journal of Personalized Medicine 14, no. 6 (2024): 657. http://dx.doi.org/10.3390/jpm14060657.

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An older age is associated with severe progression and poor prognosis in coronavirus disease 2019 (COVID-19), and mechanical ventilation is often required. The specific characteristics of older patients undergoing mechanical ventilation and their prognostic factors are largely unknown. We aimed to identify potential prognostic factors in this group to inform treatment decisions. This retrospective cohort study collected data from patients with COVID-19 at 22 medical centers. Univariate and multivariate Cox regression analyses were performed to assess factors that influence mortality. We alloca

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CAI, XIAOYAN, XIUYAN YANG, FAN LIAN, et al. "Correlation Between Serum Anti-C1q Antibody Levels and Renal Pathological Characteristics and Prognostic Significance of Anti-C1q Antibody in Lupus Nephritis." Journal of Rheumatology 37, no. 4 (2010): 759–65. http://dx.doi.org/10.3899/jrheum.090779.

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Objective.To investigate the relationship between serum anti-C1q antibody levels and renal pathological characteristics in lupus nephritis as well as the prognostic significance of serum anti-C1q antibody.Methods.Seventy-three patients with biopsy-proven lupus nephritis were enrolled. Anti-C1q antibody was measured in serum samples taken within 7 days before renal biopsy and remeasured at the end of the first and the third month after treatment. All patients were followed at least once a month for 3 months. A cross-sectional study analyzed the relationship between serum anti-C1q antibody level

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Sciascia, Savino, Martina Cozzi, Alice Barinotti, et al. "Renal Fibrosis in Lupus Nephritis." International Journal of Molecular Sciences 23, no. 22 (2022): 14317. http://dx.doi.org/10.3390/ijms232214317.

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Fibrosis can be defined as a pathological process in which deposition of connective tissue replaces normal parenchyma. The kidney, like any organ or tissue, can be impacted by this maladaptive reaction, resulting in persistent inflammation or long-lasting injury. While glomerular injury has traditionally been regarded as the primary focus for classification and prognosis of lupus nephritis (LN), increasing attention has been placed on interstitial fibrosis and tubular atrophy as markers of injury severity, predictors of therapeutic response, and prognostic factors of renal outcome in recent ye

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Bansal, Mansi, Ashok Kumar, Anup Mohta, Lalit Aggarwal, and Shadan Ali. "Abdominal wall metastasis and hyponatremia in metastatic renal cell carcinoma." International Surgery Journal 9, no. 5 (2022): 1105. http://dx.doi.org/10.18203/2349-2902.isj20221166.

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Renal cell carcinoma (RCC) is a frequently encountered urological malignancy. It accounts for 2% to 3% of all adult malignant neoplasms, and usually carries a poor prognosis. About one third of patients with RCCs have distant metastases at the time of diagnosis and in one fourth, metastasis occurs despite radical nephrectomy. The most frequent sites of metastasis include lung (50-75%), bone (30-40%), liver (30-40%), brain and thyroid (25%). Subcutaneous metastases are uncommon, with very few reported cases and typically imply a poor prognosis (3.4% incidence). Hyponatremia is a poor prognostic

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Bansal, Mansi, Ashok Kumar, Anup Mohta, Lalit Aggarwal, and Shadan Ali. "Abdominal wall metastasis and hyponatremia in metastatic renal cell carcinoma." International Surgery Journal 9, no. 5 (2022): 1105. http://dx.doi.org/10.18203/2349-2902.isj20221166.

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Renal cell carcinoma (RCC) is a frequently encountered urological malignancy. It accounts for 2% to 3% of all adult malignant neoplasms, and usually carries a poor prognosis. About one third of patients with RCCs have distant metastases at the time of diagnosis and in one fourth, metastasis occurs despite radical nephrectomy. The most frequent sites of metastasis include lung (50-75%), bone (30-40%), liver (30-40%), brain and thyroid (25%). Subcutaneous metastases are uncommon, with very few reported cases and typically imply a poor prognosis (3.4% incidence). Hyponatremia is a poor prognostic

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Aarstad, Helene Hersvik, Gigja Guðbrandsdottir, Karin M. Hjelle, et al. "The Biological Context of C-Reactive Protein as a Prognostic Marker in Renal Cell Carcinoma: Studies on the Acute Phase Cytokine Profile." Cancers 12, no. 7 (2020): 1961. http://dx.doi.org/10.3390/cancers12071961.

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High serum levels of the acute phase protein C-reactive protein (CRP) are associated with an adverse prognosis in renal cancer. The acute phase reaction is cytokine-driven and includes a wide range of inflammatory mediators. This overall profile of the response depends on the inducing event and can also differ between patients. We investigated an extended acute phase cytokine profile for 97 renal cancer patients. Initial studies showed that the serum CRP levels had an expected prognostic association together with tumor size, stage, nuclear grading, and Leibovich score. Interleukin (IL)6 family

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Makulo, JR, FB Lepira, EK Sumaili, et al. "Obesity and Renal Prognosis (Assessed by Albuminuria and eGFR) in Type 2 Diabetics in Kinshasa." January 30, 2016. https://doi.org/10.19070/2328-353X-1600030.

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Background: Obesity is associated with greater survival in end stage renal disease (ESRD). Objective: To assess the association between cardiovascular risk factors and renal Prognosis, assessed by eGFR and albumin/creatinine ratio (ACR), in Congolese Type 2 diabetic patients (T2DM). Methods: Cross-sectional study that included T2DM followed in the University hospital of Kinshasa. ACR and eGFR were used to assess the renal prognosis according to the KDIGO2012 guideline. A Logistic regression model was used to identify independent determinants of renal prognosis. Results: Patients (53 % men, 4.5

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"Obstetric Renal Failure: Causes, Prognosis, Evolution." International Journal of Women's Health care and Gynecology 4, no. 1 (2022): 1–6. http://dx.doi.org/10.36266/ijwhg/138.

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Silveira, Camila Cristina Sauder da, Matias Nunes Frizzo, and Vitor Antunes de Oliveira. "Marcadores renais como prognóstico para Covid-19." Revista Brasileira de Análises Clínicas 54, no. 4 (2022). http://dx.doi.org/10.21877/2448-3877.202200041.

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Chen, Linbao, Chao Wang, Yuning Wang, Tianyu Hong, Guangwen Zhang, and Xingang Cui. "Functions, Roles, and Biological Processes of Ferroptosis-Related Genes in Renal Cancer: A Pan-Renal Cancer Analysis." Frontiers in Oncology 11 (March 11, 2022). http://dx.doi.org/10.3389/fonc.2021.697697.

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Ferroptosis is a cell death process discovered in recent years, highly related to cancer, acute kidney injury, and other diseases. In this study, a pan-renal cancer analysis of ferroptosis-associated genes in renal cancer was performed to construct a multigene joint signature for predicting prognosis in renal cancer patients. First, gene expression profiles were downloaded from the TCGA and GTEx databases to search for genes significantly associated with renal cancer prognosis through differential gene expression analysis, weighted gene co-expression network analysis (WGCNA), and survival anal

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Liu, Puyu, Jihang Luo, Na Tan, Chengfang Li, Jieyu Xu, and Xiaorong Yang. "Establishing a prognostic model of chromatin modulators and identifying potential drug candidates in renal clear cell patients." BMC Bioinformatics 24, no. 1 (2023). http://dx.doi.org/10.1186/s12859-023-05229-9.

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Abstract Background Renal carcinoma is a common malignant tumor of the urinary system. Advanced renal carcinoma has a low 5-year survival rate and a poor prognosis. More and more studies have confirmed that chromatin regulators (CRs) can regulate the occurrence and development of cancer. This article investigates the functional and prognostic value of CRs in renal carcinoma patients. Methods mRNA expression and clinical information were obtained from The Cancer Genome Atlas database. Univariate Cox regression analysis and LASSO regression analysis were used to select prognostic chromatin-regul

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Chen, Jiasheng, Nailong Cao, Shouchun Li, and Ying Wang. "Identification of a Risk Stratification Model to Predict Overall Survival and Surgical Benefit in Clear Cell Renal Cell Carcinoma With Distant Metastasis." Frontiers in Oncology 11 (March 11, 2021). http://dx.doi.org/10.3389/fonc.2021.630842.

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Background: Clear cell renal cell carcinoma (ccRCC) is the main subtype of renal cell carcinoma and has different prognoses, especially in patients with metastasis. Here, we aimed to establish a novel model to predict overall survival (OS) and surgical benefit of ccRCC patients with distant metastasis.Methods: Using data from the Surveillance, Epidemiology, and End Results (SEER) databases, we identified 2185 ccRCC patients with distant metastasis diagnosed from 2010 to 2015. Univariate and multivariate Cox analysis were used to identify significant prognostic clinicopathological variables. By

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Yu, Zuhu, Chong Lu, Bin Lu, Hong Gao, Rongfang Liang, and Wuxing Xiang. "A novel prognostic signature for clear cell renal cell carcinoma constructed using necroptosis-related miRNAs." BMC Genomics 24, no. 1 (2023). http://dx.doi.org/10.1186/s12864-023-09258-9.

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Abstract Background This work aims to analyze the relationship between necroptosis-related microRNAs (miRNAs) and the prognosis of clear cell renal cell carcinoma (ccRCC). Methods The miRNAs expression profiles of ccRCC and normal renal tissues from The Cancer Genome Atlas (TCGA) database were used to construct a matrix of the 13 necroptosis-related miRNAs. Cox regression analysis was used to construct a signature to predict the overall survival of ccRCC patients. The genes targeted by the necroptosis-related miRNAs in the prognostic signature were predicted using miRNA databases. Gene Ontolog

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Chen, Ji, Yating Zhan, Rongrong Zhang, et al. "A New Prognostic Risk Signature of Eight Ferroptosis-Related Genes in the Clear Cell Renal Cell Carcinoma." Frontiers in Oncology 11 (June 25, 2021). http://dx.doi.org/10.3389/fonc.2021.700084.

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Clear cell renal cell carcinoma (ccRCC) is the most common renal cell carcinoma and has poor prognosis in the locally advanced stage. Ferroptosis, a relatively new type of cell death, has gained significant attention in recent years. This study aimed to explore the prognostic value of ferroptosis-related genes (FRGs) in ccRCC. In this study, 50 differentially expressed FRGs between ccRCC and adjacent normal kidney tissues were identified, 26 of them correlated with overall survival (OS) (P &lt;0.05). Eight optimal FRGs were selected by Lasso regression and multivariate Cox regression analy

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Ikram, Agrebi, Kammoun Khawla, Dammak Najla, et al. "P0497MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS IN A LMIC : EPIDEMIOLOGIC PROFILE, PROGNOSTIC FACTORS AND IMPACT OF ALPHA SMOOTH MUSCLE ACTIN." Nephrology Dialysis Transplantation 35, Supplement_3 (2020). http://dx.doi.org/10.1093/ndt/gfaa142.p0497.

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Abstract Background and Aims Mesangiocapillary glomerulonephritis (MCGN) is a rare kidney disease with a poor prognosis. Several factors have been described associated with poor renal prognosis. The contribution of alpha smooth muscle actin (α-SMA), which is involved in renal fibrogenesis, has been demonstrated in assessing the prognosis of several glomerular diseases, but few studies have concerned the MCGN. The aim of our study is to determine the epidemiologic profile, to identify prognostic factors and to evaluate the contribution of α-SMA in predicting the prognosis the MCGN. Method Our s

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