Log in

Relevant bibliographies by topics / Renal Tumors / Dissertations / Theses

To see the other types of publications on this topic, follow the link: Renal Tumors.

Dissertations / Theses on the topic 'Renal Tumors'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 dissertations / theses for your research on the topic 'Renal Tumors.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse dissertations / theses on a wide variety of disciplines and organise your bibliography correctly.

1

Patrício, Patrícia Carvalho. "Analysis of PAX2 gene alterations in renal cell tumors." Master's thesis, Faculdade de Ciências e Tecnologia, 2010. http://hdl.handle.net/10362/10574.

Full text

Abstract:

Dissertation for applying to a Master’s Degree in Molecular Genetics and Biomedicine submitted to the Sciences and Technology Faculty of New University of Lisbon<br>Background: Renal cell tumors (RCT) represent a heterogeneous group of malignancies arising from the epithelium of the renal tubules. PAX2 (Paired-box 2) is a transcription factor belonging to the evolutionarily conserved paired-box family that is required during development of the central nervous system and genitourinary tract. PAX2, which is considered a proto-oncogene, is normally suppressed at the later stages of embryonic

APA, Harvard, Vancouver, ISO, and other styles

2

Anderson, Jane Ann. "Autotaxin expression in bladder and renal cancer." Thesis, University of Birmingham, 2016. http://etheses.bham.ac.uk//id/eprint/6946/.

Full text

Abstract:

Autotaxin is an extracellular enzyme that generates lysophosphatidic acid (LPA). LPA binds up to six different cell surface G protein-coupled receptors to initiate signaling resulting in cell survival, invasion and angiogenesis. For this reason autotaxin has emerged as a therapeutic target in several different malignancies. I have used immunohistochemistry to explore the expression of autotaxin and its correlation with clinico-pathological variables in bladder and renal cancer. I show that in bladder cancer, tumours from patients with muscle invasive disease were significantly more likely to s

APA, Harvard, Vancouver, ISO, and other styles

3

Andersson, Charlotta. "Significance of Wilms’ tumor gene 1 as a biomarker in acute leukemia and solid tumors." Doctoral thesis, Umeå universitet, Institutionen för medicinsk biovetenskap, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-120912.

Full text

Abstract:

Wilms’ tumor gene 1 (WT1) is a zinc finger transcriptional regulator with crucial functions in embryonic development. Originally WT1 was described as a tumor suppressor gene, but later studies have shown oncogenic properties of WT1 in a variety of tumors. Because of its dual functions in tumorigenesis, WT1 has been described as a chameleon gene. In this thesis, the significance of WT1 as a biomarker was investigated in acute myeloid leukemia (AML), clear cell renal cell carcinoma (ccRCC), ovarian carcinoma (OC) and childhood B-cell precursor acute lymphoblastic leukemia (BCP-ALL). Previous stu

APA, Harvard, Vancouver, ISO, and other styles

4

Faust, Bethany, Candelaria MD Deimundo-Roura, Cara E. MD-PhD Marin, and Marcela MD Popescu. "Cystic Nephroma in a Child with DICER1 Mutations." Digital Commons @ East Tennessee State University, 2021. https://dc.etsu.edu/asrf/2021/presentations/48.

Full text

Abstract:

Cystic nephromas are rare, multiloculated cysts on the kidneys that occur mostly in early childhood. They are considered to be on the same spectrum as cystic partially differentiated nephroblastomas (CPDN) and Wilm’s tumors (WT). They are mostly benign, however, when cystic nephroma is associated with DICER1 mutation, the patient is predisposed to other, more aggressive tumors. DICER1 mutations are not seen in CPDN or WT, so molecular evaluation can help differentiate between them if the histology is unclear. The DICER1 gene is on chromosome 14 and it functions to make microRNA that attaches t

APA, Harvard, Vancouver, ISO, and other styles

5

Slater, Amy Amelia. "Epigenetic and genetic profiles of rare renal cancers." Thesis, University of Birmingham, 2016. http://etheses.bham.ac.uk//id/eprint/6933/.

Full text

Abstract:

The aim of this study was to characterise the genetic and epigenetic profiles of rare forms of sporadic renal cancers (RCC) and identify differential patterns of DNA methylation or somatic mutations that may permit distinction between different subtypes of RCC and could facilitate disease prognosis or identify molecular pathways that could be targeted therapeutically. Illumina Infinium HumanMethylation 450K BeadChip permitted the comparison of the epigenome of the malignant chromophobe RCC and the benign renal oncocytoma. This study identified several genes to be differentially hypermethylated

APA, Harvard, Vancouver, ISO, and other styles

6

Jafri, Mariam. "Molecular characterisation of renal cell carcinoma and related disorders." Thesis, University of Birmingham, 2016. http://etheses.bham.ac.uk//id/eprint/6996/.

Full text

Abstract:

Over the last two decades genetic advances have provided novel insights into the molecular basis of familial and sporadic cancers and provided the basis for the development of novel therapeutic approaches. For example, the identification of the gene for von Hippel Lindau disease provided seminal insights into its role in most clear cell renal carcinomas (RCC) and led to new treatments for RCC. In this thesis I investigated three related genetic aspects of neoplasia. Firstly, I analyzed the results of genetic testing for inherited phaeochromocytoma and investigated how clinical features could b

APA, Harvard, Vancouver, ISO, and other styles

7

Ogawa, Osamu. "Molecular Genetic Analysis of Human Renal Tumors by Using Restriction Fragment Length Polymorphisms." Kyoto University, 1994. http://hdl.handle.net/2433/160715.

Full text

Abstract:

本文データは平成22年度国立国会図書館の学位論文(博士)のデジタル化実施により作成された画像ファイルを基にpdf変換したものである<br>Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(医学)<br>甲第5794号<br>医博第1587号<br>新制||医||590(附属図書館)<br>UT51-94-R318<br>京都大学大学院医学研究科外科系専攻<br>(主査)教授野田亮, 教授佐々木正夫, 教授吉田修<br>学位規則第4条第1項該当

APA, Harvard, Vancouver, ISO, and other styles

8

Meadows, Susan Dove. "PERSISTENT NEPHROTOXICITY AND RENAL TUMOR PROMOTION IN SWISS-WEBSTER MICE FOLLOWING EXPOSURE TO 1,2-DICHLOROVINYLCYSTEINE (KIDNEY, CANCER)." Thesis, The University of Arizona, 1985. http://hdl.handle.net/10150/275292.

Full text

APA, Harvard, Vancouver, ISO, and other styles

9

Queiroz, Marcus Vinicius Baptista. "Ablação percutânea do parênquima renal por radiofrequência." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/5/5153/tde-04082011-155239/.

Full text

Abstract:

INTRODUÇÃO: Os tumores renais pequenos e localizados são hoje diagnosticados mais frequentemente graças ao uso mais intenso dos métodos de imagem, o que favorece técnicas de tratamento menos traumáticas e igualmente eficazes. Dentre as técnicas minimamente invasivas, uma alternativa atraente é a radiofrequência (RF) por ser eficiente, de baixo custo e fácil aplicação. OBJETIVO: Avaliar métodos de aprimoramento da aplicação da RF para promover lesão celular renal de forma mais eficiente, obtendo lesões maiores, utilizando diferentes temperaturas e, em seguida, administrar drogas vasoativas para

APA, Harvard, Vancouver, ISO, and other styles

10

Gutteridge, Robert. "Caveolin-1 is a modulator of clonogenicity in renal cell carcinoma." Thesis, Cardiff University, 2015. http://orca.cf.ac.uk/91911/.

Full text

Abstract:

Renal cell carcinoma (RCC) represents a group of aggressive tumours of the kidney. These tumours have a high propensity for metastasis and are extremely treatment refractive after disease relapse. Therefore, the identification of new therapeutic targets is of great importance. One such potential target for therapy are cancer stem cells (CSCs). CSCs are populations of cells imbued with a stem cell-like phenotype capable of driving tumour formation, metastasis and chemoresistance. As such, reliable methods for the identification of CSC populations and defining targets important to their function

APA, Harvard, Vancouver, ISO, and other styles

11

Nahorski, Michael Stefan. "Investigation into the molecular mechanisms of inherited renal cancer." Thesis, University of Birmingham, 2012. http://etheses.bham.ac.uk//id/eprint/3663/.

Full text

Abstract:

Birt Hogg Dubé (BHD) syndrome is an inherited cancer susceptibility syndrome characterised by the development of fibrofolliculomas on the face and upper torso, and increased risk of lung cysts, spontaneous pneumothorax and renal cancer. The findings presented in this thesis advance knowledge into how the mutations in the FLCN gene cause the phenotypes associated with BHD syndrome, and provides novel insights into the functions of folliculin within the cell. The results presented provide further evidence of the association between BHD syndrome and increased risk of colorectal cancer in a subse

APA, Harvard, Vancouver, ISO, and other styles

12

Lawrentschuk, Nathan Leo. "Hypoxia and angiogenesis in renal cell carcinoma." Connect to thesis, 2009. http://repository.unimelb.edu.au/10187/6790.

Full text

Abstract:

Hypoxia is one of the hallmarks of cancer. It was first postulated to occur in solid tumours by Thomlinson and Gray in 1955.1 The presence of hypoxia has been demonstrated in different types of solid tumours.2 Intratumoral hypoxia is caused by the lack of functional blood vessels in proliferating tumour tissue, resulting in low intratumoral oxygen concentrations. If hypoxia is severe or prolonged, cell death occurs.3 Malignant cells can undergo genetic and adaptive changes that allow them to escape from dying of oxygen deprivation. These changes are associated with a more aggressive malignant

APA, Harvard, Vancouver, ISO, and other styles

13

O'Flaherty, Linda H. "Development of novel in vitro and in vivo models for determining primary events in HLRCC tumourigenesis." Thesis, University of Oxford, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.565984.

Full text

Abstract:

Development of novel ill vitro and ill vivo models for determining primary events in HLRCC tumourigenesis Linda O'Flaherty, Mansfield College Thesis submitted for degree of Doctor of Philosophy Nuffield Department of Clinical Medicine, University of Oxford Hilary Term 2012 Germline mutations of fumarate hydratase (FR), encoding an enzyme of the tricarboxylic acid (TCA) cycle, predispose affected individuals to hereditary leiomyomatosis and renal cell cancer (HLRCC). FH-deficient cells and tissues have been shown to accumulate fumarate, exhibit S-(2-succinyl) cysteine (2SC) protein modification

APA, Harvard, Vancouver, ISO, and other styles

14

Oldham, Kimberley Anne. "The recruitment and role of effector and regulatory T cells in renal cell carcinoma." Thesis, University of Birmingham, 2012. http://etheses.bham.ac.uk//id/eprint/3263/.

Full text

Abstract:

Immunotherapy for renal cell carcinoma (RCC) has yielded some clinical responses. However this approach frequently fails, possibly due to inefficient migration of T-cells to tumour tissue or immunosuppressive mechanisms within the tumour environment. To aid development of T-cell therapy for RCC I investigated how T-cells are recruited to this tumour, which T-cell subsets infiltrate, and how they function. Analysis of the expression of all 19 chemokine receptors on matched TIL and PBMC demonstrated that CCR5, CXCR3 and CXCR6 were expressed at significantly higher levels on tumour-infiltrating T

APA, Harvard, Vancouver, ISO, and other styles

15

Schütte, Ute [Verfasser]. "The role of the Hippo pathway in etiology and progression of pancreato-biliary tumors and clear cell renal cell carcinoma / Ute Schütte." Bonn : Universitäts- und Landesbibliothek Bonn, 2016. http://d-nb.info/1125526386/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

16

Morel, Daphné. "Identifying Synthetic Lethal and Selective Approaches to Target PBRM1-Deficiency in Clear Cell Renal Cell Carcinoma PBRM1 Deficiency in Cancer is Synthetic Lethal with DNA Repair Inhibitors Exploiting Epigenetic Vulnerabilities in Solid Tumors: Novel Therapeutic Opportunities in the Treatment of SWI/SNF-Defective Cancers Combining Epigenetic Drugs with other Therapies for Solid Tumours — Past Lessons and Future Promise Targeting Chromatin Defects in Selected Solid Tumors Based on Oncogene Addiction, Synthetic Lethality and Epigenetic Antagonism." Thesis, université Paris-Saclay, 2020. http://www.theses.fr/2020UPASL017.

Full text

Abstract:

L’inactivation de polybromo-1 (PBRM1) est un évènement fréquent dans de nombreux cancers. En particulier, les carcinomes rénaux à cellules claires présentent une déficience en PBRM1 dans 40 à 50% des cas. A ce jour, il n’existe pas d’approche de médecine précision connue capable de cibler spécifiquement les cellules tumorales déficientes en PBRM1.Pour identifier des cibles de létalité synthétique associées à la perte de PBRM1, nous avons (i) réalisé un criblage pharmacologique à haut débit évaluant la sensibilité à 167 molécules dans un modèle cellulaire isogénique pour PBRM1, et (ii) étudié l

APA, Harvard, Vancouver, ISO, and other styles

17

Iizuka, Yusuke. "Dynamic tumor-tracking radiotherapy with real-time monitoring for liver tumors using a gimbal mounted linac." Kyoto University, 2016. http://hdl.handle.net/2433/215388.

Full text

APA, Harvard, Vancouver, ISO, and other styles

18

Aarab-Terrisse, Safae. "Impact de l'axe microbiome-thymus sur l'efficacité de la déprivation androgénique et sur le renforcement de l’immuno-surveillance dans le cancer de la prostate Immunodynamics of Explanted Human Tumors for Precision and Personalized Immuno-Oncology Gut Bacteria Composition Drives Primary Resistance to Cancer Immunotherapy in Renal Cell Carcinoma Patients." Thesis, université Paris-Saclay, 2020. http://www.theses.fr/2020UPASL025.

Full text

Abstract:

La déprivation androgénique est la pierre angulaire du traitement du cancer de la prostate (CaP), mais la plupart des patients deviendront réfractaires à la castration (CRPC). En outre, les immunothérapies par inhibiteurs de points de contrôle immunitaire ne sont pour l’instant pas un standard dans la prise en charge de ce cancer en raison de son environnement immunosuppresseur. Notre hypothèse est que pour accroître la sensibilité des patients aux traitements immuno-modulateurs (déprivation androgénique, inhibiteurs des points de contrôle immunitaire et autres), il faudrait restaurer l’enviro

APA, Harvard, Vancouver, ISO, and other styles

19

Hellström, Vivan. "The clinical perspective on malignancies in renal transplanted patients." Doctoral thesis, Uppsala universitet, Transplantationskirurgi, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-282131.

Full text

Abstract:

Post-transplant malignancies cause significant morbidity and mortality. In this thesis we investigated malignancies in renal transplanted patients from a clinical viewpoint. The use of regional tumour registries considerably improved identification of pre- and post-transplant malignancies, which are generally underreported in transplant registries. Despite previously adequate cancer treatments with favourable prognosis, patients with pre-transplant malignancies showed higher incidence of post-transplant cancer and reduced survival compared to a 1:3 ratio matched control group of patients witho

APA, Harvard, Vancouver, ISO, and other styles

20

Hudon, Valerie. "Investigating tumor suppressor genes involved in renal cell carcinomas." Thesis, McGill University, 2010. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=86607.

Full text

Abstract:

Kidney cancer is a complex disease comprising several types of renal carcinomas, which are classified in different subtypes based on their histological characteristics. A small number of cases of renal cancers are due to hereditary predispositions and nearly all the knowledge on the molecular pathogenesis of kidney cancers was learned by the investigation of these hereditary forms of renal carcinomas. In this thesis, we studied two hereditary diseases predisposing to the development of kidney cancer, von Hippel Lindau (VHL) and Birt-Hogg-Dubé (BHD) syndromes, and their causative genes, VHL and

APA, Harvard, Vancouver, ISO, and other styles

21

STELLA, MARTINA. "Identification of molecular alterations associated with the progression of clear cell Renal Cell Carcinoma by mass spectrometric approaches." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2019. http://hdl.handle.net/10281/241159.

Full text

Abstract:

Il carcinoma a cellule renali rappresenta la più frequente forma di tumore al rene, e il carcinoma a cellule chiare ne è il morfotipo più ricorrente (80% dei casi). Ad oggi la nefrectomia, totale o parziale, rimane il trattamento di elezione. E’ evidente, quindi, la necessità di indagare a fondo gli aspetti molecolari associati alla progressione del tumore, con il fine ultimo di produrre conoscenze utili alla diagnosi o trattamento delle lesioni stesse. In questo lavoro abbiamo utilizzato approcci proteomici complementari per lo studio dei processi associati all’insorgenza e alla progressione

APA, Harvard, Vancouver, ISO, and other styles

22

Dijkhuizen, Trijntje. "Genetic contributions to the classification of renal cell cancer." [S.l. : [Groningen] : s.n.] ; [University Library Groningen] [Host], 1997. http://irs.ub.rug.nl/ppn/159282535.

Full text

APA, Harvard, Vancouver, ISO, and other styles

23

Heiz, Monika. "Growth control and L1-CAM phosphorylation in renal tumor cells diploma work /." Zürich : ETH, Eidgenössische Technische Hochschule Zürich, Departement Angewandte Biowissenschaften, Institut für Pharmazeutische Wissenschaften, 2000. http://e-collection.ethbib.ethz.ch/show?type=dipl&nr=14.

Full text

APA, Harvard, Vancouver, ISO, and other styles

24

Li, Tak-kin, and 李德健. "A study of Twist and DJ-1 expressions and their clinical significance in renal cell carcinoma of clear cell type." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B45153863.

Full text

APA, Harvard, Vancouver, ISO, and other styles

25

Wilkins, Danice E. C. "CD40 stimulation induces chemokine production and anti-tumor effects in renal cell carcinoma." abstract and full text PDF (free order & download UNR users only), 2007. http://0-gateway.proquest.com.innopac.library.unr.edu/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:1442869.

Full text

APA, Harvard, Vancouver, ISO, and other styles

26

Khurram, Muhammad Arslan. "Transplantation with kidneys removed for small renal tumours : immunosuppressive strategies and role of rejection." Thesis, University of Sunderland, 2017. http://sure.sunderland.ac.uk/8559/.

Full text

Abstract:

Renal transplantation is the definitive treatment for the end-stage renal failure. Despite concerted efforts to increase the number of available organs there remains a wide gap. Kidneys with small renal cell carcinoma have been used for transplantation after ex vivo resection of tumours with excellent results. Concerns regarding the behaviour of tumour under standard immunosuppression prevent this source from being popularised. We studied tumour behaviour with standard immunosuppression and immunosuppressives with anti-proliferative properties and the effect of MHC matching on tumour behaviour

APA, Harvard, Vancouver, ISO, and other styles

27

Petitprez, Florent. "Integrated analysis and clinical impact of immune and stromal microenvironments in solid tumors Quantitative analyses of the tumor microenvironment composition and orientation in the era of precision medicine Transcriptomic analysis of the tumor microenvironment to guide prognosis and immunotherapies Tumor microenvironment quantification tool draws a comprehensive map of the tumor microenvironment of non-hematologic human cancers The mMCP-counter method to estimate abundance of tissue-infiltrating immune and stromal cell populations using gene expression in murine samples Immune sub-classes in sarcoma predict survival and immunotherapy response Intra-tumoral tertiary lymphoid structures are associated with a low risk of hepatocellular carcinoma early recurrence Association of IL-36γ with tertiary lymphoid structures and inflammatory immune infiltrates in human colorectal cancer Immune-based identification of cancer patients at high risk of progression Tumor-infiltrating and peripheral blood T-cell immunophenotypes predict early relapse in localized clear cell renal cell carcinoma PD-L1 expression and CD8+ T-cell infiltrate are associated with clinical progression in patients with node-positive prostate cancer Intratumoral classical complement pathway activation promotes cancer progression". Thesis, Sorbonne Paris Cité, 2018. http://www.theses.fr/2018USPCB104.

Full text

Abstract:

Les tumeurs sont composées de cellules malignes et d'une grande variété de cellules non-tumorales, en particulier des cellules immunitaires qui forment le micro-environnement tumoral (MET). Il a été démontré que la composition du MET était associée au devenir clinique des patients, en termes de survie et de réponses thérapeutiques. Avec le développement récent des immunothérapies qui ciblent des éléments spécifiques du MET, l'immunité anti-tumorale a soulevé un intérêt majeur. Plusieurs méthodologies ont été mises au point afin d'étudier la composition du MET, avec une précision toujours plus

APA, Harvard, Vancouver, ISO, and other styles

28

Koczuła, Katarzyna Malgorzata. "Real-time metabolic flux in chronic lymphocytic leukaemia cells adapting to the hypoxic niche." Thesis, University of Birmingham, 2015. http://etheses.bham.ac.uk//id/eprint/6067/.

Full text

Abstract:

Although knowledge of metabolic adaptations in cancer has increased dramatically, little is known about the spontaneous adoptive adaptations of cancer cells to changing conditions in the body. This is particularly important for chronic lymphocytic leukaemia (CLL) cells which continually circulate between different microenvironments in the blood, bone marrow and lymph nodes. To study such metabolic adaptations, a nuclear magnetic resonance (NMR) based approach; capable of monitoring real-time metabolism in primary CLL cells was developed. Using this setup, this thesis demonstrates fast, reversi

APA, Harvard, Vancouver, ISO, and other styles

29

CAZZANIGA, MARTA. "Ricerca di una firma molecolare tipizzante tumori renali mediante approccio proteomico di profiling in spettrometria di massa." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2016. http://hdl.handle.net/10281/104019.

Full text

Abstract:

Renal cell carcinoma accounts for about 85% of primary kidney tumors and its incidence worldwide is increasing rapidly. Although the diagnosis of RCC is routinely performed by means of multiple imaging techniques, benign solid renal masses sometimes cannot be confidently differentiated from malignant ones. Moreover, the TNM (Tumor-Node-Metastasis) classification system, the Fuhrman grading system and serum markers are still the main factors used to predict the outcome of patients. For these reasons, RCC still remains a significant clinical challenge not only in terms of early diagnosis but als

APA, Harvard, Vancouver, ISO, and other styles

30

Blanco, Marcos Luengo. "Efeitos da geleia real sobre a resposta hematopoetica em camundongos portadores do tumor ascitico de Ehrlich." [s.n.], 2001. http://repositorio.unicamp.br/jspui/handle/REPOSIP/308721.

Full text

Abstract:

Orientador: Claudia Bincoletto Trindade<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas<br>Made available in DSpace on 2018-07-31T17:53:34Z (GMT). No. of bitstreams: 1 Blanco_MarcosLuengo_M.pdf: 11771640 bytes, checksum: 07eeb35ecb8cbf763d5f368dcb0e178f (MD5) Previous issue date: 2001<br>Resumo: Diante da importância da resposta hematopoética na sobrevivência de animais portadores do Tumor Ascítico de Ehrlich (TAE), neste trabalho avaliou-se os efeitos in vivo da Geléia Real (GR) sobre a hematopoese medular e esplênica de animais portadores do TAE

APA, Harvard, Vancouver, ISO, and other styles

31

Scalera, Giovanni Battista. "Risonanza Magnetica Dinamica e TC multifasica nella caratterizzazione dei tumori renali di piccole dimensioni (<3cm)." Doctoral thesis, Università di Catania, 2012. http://hdl.handle.net/10761/1112.

Full text

Abstract:

Allo stato attuale RM dinamica e TC multifasica mediante l analisi dell enhancement consentono informazioni quali- quantitative della vascolarizzazione di piccoli tumori renali e quindi una più accurata caratterizzazione. TIPOLOGIA DELLO STUDIO ED OBIETTIVI Studio retrospettivo di piccole masse renali con diagnosi istologica, identificate con ecografia e/o con TC trifasica. OBIETTIVO PRIMARIO: Confrontare i risultati della RM dinamica e della TC trifasica nella valutazione quali- quantitativa dell enhacement dei carcinomi renali di piccole dimesioni. OBIETTIVO SECONDARIO: Valutare la po

APA, Harvard, Vancouver, ISO, and other styles

32

Ferreira, Adilson Kleber. "Alquil fosfatado sintético precursor dos fosfolipídios da membrana celular com potencial efeito antitumoral e apoptótico em modelos de tumores experimentais." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/5/5160/tde-20052013-145336/.

Full text

Abstract:

Neste estudo foram avaliados os efeitos antitumorais da fosfoetanolamina sintética (FS) em modelos de tumores experimentais e as vias de sinalizações envolvidas nesta atividade. In vitro a FS foi citotóxica para as linhagens de células tumorais de melanoma humano, SK-MEL-28, carcinoma renal murino RENCA e para as células do carcinoma de pulmão de não pequenas células NSCLC. Alterações ultraestruturais como a condensação da cromatina, formação de blubes de membranas e mitocôndrias eletrodensas foi acompanhada pela redução do potencial elétrico mitocondrial. Aumento da ativação da caspase 3 e 8

APA, Harvard, Vancouver, ISO, and other styles

33

Bianchi, Lorenzo <1987&gt. "3D modelling per la pianificazione preoperatoria nella chirurgia conservativa dei tumori renali." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2022. http://amsdottorato.unibo.it/10047/1/Bianchi_Lorenzo_tesi.pdf.

Full text

Abstract:

Lo scopo del progetto è quello di valutare l’impatto clinico dell’ utilizzo del 3D modeling nella pianificazione chirurgica preoperatoria della PN. Sono stati arruolati in modo prospettico 195 pazienti con diagnosi di neoplasia renale T1 candidati a PN tra dicembre 2018 e agosto 2021. Prima dell’intervento chirurgico tutti i pazienti sono stati sottoposti a imaging 2D (TC torace-addome con mezzo di contrasto). Per valutare il ruolo e l’impatto clinico del 3D modelling sulla pianificazione chirurgica, la popolazione è stata suddivisa in due gruppi: gruppo di studio (n=100 pazienti), comprende

APA, Harvard, Vancouver, ISO, and other styles

34

Oliveira, Rita de Cássia. "Perfil de expressão de microRNAs envolvidos na regulação de genes associados à angiogênese no carcinoma renal das células claras." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/5/5153/tde-26012017-102913/.

Full text

Abstract:

INTRODUÇÃO: O Carcinoma de Células Renais (CCR) é reposnsável por mais de 200.000 casos a cada ano no mundo, representando cerca de 2% de todos os cânceres. O CCR do tipo células claras (CRCC) é o subtipo mais comum da doença e é responsável por 75 a 80% dos casos, com maiores taxas de invasão local, desenvolvimento de metástases e mortalidade. As novas terapias alvo são baseadas em moléculas e anticorpos antiangiogênicos alterando o curso da doença, mas os resultados até agora não são satisfatórios. OBJETIVOS: Nosso objetivo nesse estudo foi estudar miRNAs e seus possíveis genes alvo relacion

APA, Harvard, Vancouver, ISO, and other styles

35

Brito, Glauber da Costa de. "Análise da expressão de RNAs intrônicos não-codificadores em carcinomas de célula renal." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/46/46131/tde-07022008-100457/.

Full text

Abstract:

O carcinoma de célula renal (CCR) subtipo célula clara é o câncer mais letal e prevalente do sistema urinário. A transformação maligna no CCR está possivelmente associada à mudanças no perfil de expressão de oncogenes e genes supressores de tumor, e acredita-se que estas alterações sejam críticas para o desenvolvimento do fenótipo maligno. Para identificar novos genes e vias moleculares associadas à transformação maligna no CCR célula clara, foram analisados perfis de expressão gênica de amostras pareadas de tumor e tecido não tumoral adjacente de 6 pacientes. Foi utilizada uma platafo

APA, Harvard, Vancouver, ISO, and other styles

36

Cheung, Yee-wan. "Quantitative analysis of hTERT mRNA expression in gestational trophoblastic disease by real-time PCR." Hong Kong : University of Hong Kong, 2002. http://sunzi.lib.hku.hk/hkuto/record.jsp?B25139198.

Full text

APA, Harvard, Vancouver, ISO, and other styles

37

Barod, R. "Role of the VHL and PTEN tumour suppressors in clear cell renal carcinoma." Thesis, University College London (University of London), 2011. http://discovery.ucl.ac.uk/1331702/.

Full text

Abstract:

Kidney cancer affects over 7000 people each year in the UK and its incidence is rising. The majority of patients with clear cell renal carcinoma (ccRCC), the commonest form, harbour mutations in the VHL tumour suppressor. Experimental studies have shown that VHL inactivation is an early, important step in the development of ccRCC. The main identified function of VHL is the regulation of hypoxia inducible factor (HIF). HIF has 2 main isoforms (HIF-1α and HIF-2α), which act as the master regulator of the cellular response to hypoxia and regulate the transcription of several genes. While loss o

APA, Harvard, Vancouver, ISO, and other styles

38

Lima, José de Ribamar Oliveira. "Perfil da cistatina C, interleucina 2, interleucina 6 e fator de necrose tumoral alfa em receptores de transplante renal." reponame:Repositório Institucional da UnB, 2011. http://repositorio.unb.br/handle/10482/9718.

Full text

Abstract:

Tese (doutorado)—Universidade de Brasília, Faculdade de Ciências da Saúde, Programa de Pós-Graduação em Ciências da Saúde, 2011.<br>Submitted by Albânia Cézar de Melo (albania@bce.unb.br) on 2011-10-27T15:35:18Z No. of bitstreams: 1 2011_JoseRibamarOliveiraLima.pdf: 1357177 bytes, checksum: 179cf19f3cfdb4a0c63349349d11fe0d (MD5)<br>Approved for entry into archive by Leila Fernandes (leilabiblio@yahoo.com.br) on 2011-12-13T11:42:07Z (GMT) No. of bitstreams: 1 2011_JoseRibamarOliveiraLima.pdf: 1357177 bytes, checksum: 179cf19f3cfdb4a0c63349349d11fe0d (MD5)<br>Made available in DSpace on 2011-

APA, Harvard, Vancouver, ISO, and other styles

39

Zastrow, Stefan, Anh Phuong, Immanuel von Bar, Vladimir Novotny, Oliver W. Hakenberg, and Manfred P. Wirth. "Primary Tumor Size in Renal Cell Cancer in Relation to the Occurrence of Synchronous Metastatic Disease." Karger, 2014. https://tud.qucosa.de/id/qucosa%3A70551.

Full text

Abstract:

Objectives: To investigate the controversially discussed relationship between tumor size and the occurrence of primary synchronous metastatic disease in renal cell cancer (RCC). Patients and Methods: A consecutive RCC cohort of 2,058 patients (150 primary metastatic) who underwent surgery between 1995 and 2010 was investigated. Rates of synchronous metastases were calculated for stratified groups of tumor size. Uni- and multivariate logistic regression models were calculated for the correlation of tumor size with primary metastatic disease. Results: The rate of metastatic disease increased wi

APA, Harvard, Vancouver, ISO, and other styles

40

Schnappinger, Julia [Verfasser], and Elfriede [Akademischer Betreuer] Nößner. "Profiling human tumor infiltrating leukocytes comparing renal cell and hepatocellular carcinoma / Julia Schnappinger ; Betreuer: Elfriede Nößner." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2019. http://d-nb.info/1225682452/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

41

Cohen, Jennifer Diane. "Engagement of Map Kinase and mTOR Signalingn by the TSC-2 Tumor Suppressor in Renal Cancer." Diss., The University of Arizona, 2009. http://hdl.handle.net/10150/195527.

Full text

Abstract:

The tuberous sclerosis-2 (Tsc-2) gene product, tuberin, functions as a renal tumor suppressor. Treatment of Eker (Tsc-2 EK/+) rats and primary renal epithelial cells derived from Tsc-2 EK/+ rats (QTRRE cells) with 2,3,5-tris-(glutathion-S-yl) hydroquinone (TGHQ) results in loss of heterozygosity at the Tsc-2 locus in kidney tumors and QTRRE cells. QTRRE cells are carcinogenic in athymic nude mice. Analysis of kidney tumors formed in Tsc-2 EK/+ + rats following 8-months of TGHQ treatment reveals increases in B-Raf, Raf-1, pERK, cyclin D1, p27Kip1, 4EBP1, p-4EBP1(Thr70), p-4EBP1(Ser65), and p

APA, Harvard, Vancouver, ISO, and other styles

42

Arakaki, Ryuichiro. "CCL2 as a potential therapeutic target for clear cell renal cell carcinoma." 京都大学 (Kyoto University), 2017. http://hdl.handle.net/2433/225490.

Full text

APA, Harvard, Vancouver, ISO, and other styles

43

Carretto, Elena. "Tumori rari pediatrici come spia di sindromi genetiche: un report dal progetto TREP (Tumori Rari in Età pediatrici) su carcinoma renale e feocromocitoma." Doctoral thesis, Università degli studi di Padova, 2009. http://hdl.handle.net/11577/3426505.

Full text

Abstract:

We consider rare tumors in pediatric age those tumors with an incidence less than 2 cases/1.000.000 children/year, which are not included in treatment protocols of the Associazione Italiana di Emato-Oncologia Pediatrica (AIEOP). These tumors are object of a national project called TREP, aiming to register patients with rare tumors and promote studies of these cancers. We hypothesize that infancy-onset of typically adulthood tumors, extremely rare in pediatric age, could be the expression of an underlying predisposing genetic condition. In fact, the earliest is the age of onset, the least is

APA, Harvard, Vancouver, ISO, and other styles

44

Terachi, Toshiro. "Coexistence of Autologous Antibodies and Decay-accelerating Factor, an Inhibitor of Complement, on Human Renal Tumor Cells." Kyoto University, 1993. http://hdl.handle.net/2433/168843.

Full text

Abstract:

本文データは平成22年度国立国会図書館の学位論文(博士)のデジタル化実施により作成された画像ファイルを基にpdf変換したものである<br>Kyoto University (京都大学)<br>0048<br>新制・論文博士<br>博士(医学)<br>乙第8045号<br>論医博第1414号<br>新制||医||552(附属図書館)<br>UT51-93-B317<br>(主査)教授湊長博, 教授日合弘, 教授吉田修<br>学位規則第4条第2項該当

APA, Harvard, Vancouver, ISO, and other styles

45

張綺雲 and Yee-wan Cheung. "Quantitative analysis of hTERT mRNA expression in gestational trophoblastic disease by real-time PCR." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2002. http://hub.hku.hk/bib/B31970436.

Full text

APA, Harvard, Vancouver, ISO, and other styles

46

Tassetano, Renata Cristina Tornelli [UNIFESP]. "Estudo comparativo do efeito da Echinácea purpúrea e sorafenibe em células de adenocarcinoma renal humano em cultura." Universidade Federal de São Paulo (UNIFESP), 2010. http://repositorio.unifesp.br/handle/11600/9506.

Full text

Abstract:

Made available in DSpace on 2015-07-22T20:50:04Z (GMT). No. of bitstreams: 0 Previous issue date: 2010-09-29<br>Introdução: O carcinoma renal (CR) é relativamente raro comparado a outros cânceres. Um dos mais potentes mitógenos tumorais, o fator de crescimento endotelial vascular, VEGF, é regulado por inúmeras vias, particularmente Ras e Akt, que são alvo de inúmeros agentes terapêuticos, dentre eles o sorafenibe. Estas vias de sinalização têm importante papel no desenvolvimento e manutenção da resistência a múltiplas drogas (MDR). A Echinácea purpúrea é utilizada como tratamento alternativ

APA, Harvard, Vancouver, ISO, and other styles

47

Holton, Angela. "Microfluidic Biopsy Trapping Device for the Real-time Monitoring of the Tumor Microenvironment." Scholar Commons, 2017. http://scholarcommons.usf.edu/etd/7036.

Full text

Abstract:

The tumor microenvironment is composed of cellular and stromal components such as tumor cells, mesenchymal cells, immune cells, cancer associated fibroblasts and the supporting extracellular matrix. The tumor microenvironment provides crucial support for growth and progression of tumor cells and affects tumor response to therapeutic interventions. To better understand tumor biology and to develop effective cancer therapeutic agents it is important to develop preclinical platforms that can faithfully recapitulate the tumor microenvironment and the complex interaction betwe

APA, Harvard, Vancouver, ISO, and other styles

48

Apostolopoulos, Vasileios. "Real time intraoperative three dimensional ultrasound in biopsy and resection of intrinsic brain tumours." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/24922.

Full text

Abstract:

There is growing evidence that maximal surgical resection of malignant gliomas is beneficial, both by increasing the progression free survival (Stummer, Pichlmeier et al. 2006) and also by facilitating postoperative chemotherapy and radiotherapy (Stupp, Mason et al. 2005). In this context there has been an increased need for real time intraoperative imaging in brain tumour surgery. The complex theatre arrangements, prohibitive cost and prolonged theatre time has restricted the wide application of intraoperative MRI (iMRI). Modern intraoperative ultrasound, which in the past has been relatively

APA, Harvard, Vancouver, ISO, and other styles

49

Kiweler, Nicole [Verfasser]. "Impact of class I HDACs and their inhibitors on renal and colorectal tumor cell fate decisions / Nicole Kiweler." Mainz : Universitätsbibliothek Mainz, 2019. http://d-nb.info/1193687411/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

50

Senatore, Marcela Andrea Duran Haun 1974. "Meta-análise : estudos da efetividade de terapias com fármacos alvo moleculares para o tratamento do tumor renal metastático." [s.n.], 2014. http://repositorio.unicamp.br/jspui/handle/REPOSIP/313127.

Full text

Abstract:

Orientadores: Wagner Eduardo Matheus, Ubirajara Ferreira<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas<br>Made available in DSpace on 2018-08-24T12:07:43Z (GMT). No. of bitstreams: 1 Senatore_MarcelaAndreaDuranHaun_D.pdf: 1829482 bytes, checksum: bc20dee71d7524f229d7b76160f9e38b (MD5) Previous issue date: 2014<br>Resumo: Atualmente existem diferentes agentes para o tratamento do câncer renal avançado. O objetivo principal desse trabalho foi realizar revisão sistemática com meta-análise dos estudos clínicos randomizados que compararam: sorafenibe, suni

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!