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Dissertations / Theses on the topic 'Repeat sequences'

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1

Arner, Erik. "Solving repeat problems in shotgun sequencing /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-996-3/.

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2

Asefifeyzabadi, Narges. "DNA INTERFACES FOR ELECTROCHEMICAL DETECTION OF NEURODEGENERATIVE REPEAT SEQUENCES." OpenSIUC, 2021. https://opensiuc.lib.siu.edu/dissertations/1931.

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TITLE: DNA INTERFACES FOR ELECTROCHEMICAL DETECTION OF NEURODEGENERATIVE REPEAT SEQUENCES DNA repeat sequences in the human genome possess unique biophysical properties due to their sequence-directed structural flexibility. It has been assumed that unique helical flexibility of these sequences forms non-canonical structures inside the cell that disrupts transcription/translation functions and can lead to variety of fatal diseases such as neurodegenerative disorders. Neorodegenerative diseases are caused by certain types of mutations called repeat expansions. Expansion of certain trinucleotide
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3

Hau, Peter P. C. "Minisatellite variant repeat mapping of the D1S7 locus (MS1)." Thesis, University of Strathclyde, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.273450.

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4

Rehm, Charlotte [Verfasser]. "G-Quadruplex Forming Repeat Sequences In Bacterial Genomes / Charlotte Rehm." Konstanz : Bibliothek der Universität Konstanz, 2015. http://d-nb.info/1115726609/34.

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5

Stevens, Hannah Clare. "Potential mechanisms by which herpes virus tandem repeat sequences modulate latency and reactivation." Thesis, University of Liverpool, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.533921.

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6

Whiteford, Nava. "String matching in DNA sequences : implications for short read sequencing and repeat visualisation." Thesis, University of Southampton, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.438668.

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7

Meloney, Kathleen Ann. "A dynamical systems approach to estimating the sequences of repeat regions in the genome." College Park, Md. : University of Maryland, 2004. http://hdl.handle.net/1903/1355.

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Thesis (M.A.) -- University of Maryland, College Park, 2004.<br>Thesis research directed by: Dept. of Mathematics. Title from t.p. of PDF. Includes bibliographical references. Published by UMI Dissertation Services, Ann Arbor, Mich. Also available in paper.
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8

Brind'Amour, Julie. "Flow cytometry analysis and sorting of chromosomes following hybridization with fluorescent probes that target specific DNA repeat sequences." Thesis, University of British Columbia, 2011. http://hdl.handle.net/2429/35973.

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Traditional cytogenetic approaches allow analysis of the chromosomal composition (karyotype) of mitotic cells fixed on slides cells by microscopy. The combination of karyotyping and Fluorescence In Situ Hybridization (FISH) enables the detection of specific target sequences on individual chromosomes. Disadvantages are that traditional cytogenetic approaches are very labor and time consuming and that chromosome specific information from only a few dozen cells has poor statistical power. An alternative is flow karyotyping, a method to analyze chromosomes in suspension by flow cytometry. For flow
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9

Kathuria, Sagar V. "Sequence Determinants of the Folding Free-Energy Landscape of beta alpha-Repeat Proteins: A Dissertation." eScholarship@UMMS, 2010. https://escholarship.umassmed.edu/gsbs_diss/480.

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The most common structural platform in biology, the βα-repeat classes of proteins, are represented by the (βα)8TIM barrel topology and the α/β/α sandwich, CheY-like topology. Previous studies on the folding mechanisms of several members of these proteins have suggested that the initial event during refolding involves the formation of a kinetically trapped species that at least partially unfolds before the native conformation can be accessed. The simple topologies of these proteins are thought to permit access to locally folded regions that may coalesce in non-native ways to form stable interac
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10

Shelton, Catherine L. "Conserved Variation in Tandem Repeat Sequences Tunes the Self-Assembly and Stability Characteristics of the Staphylococcus epidermidis Biofilm Protein Aap." University of Cincinnati / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1470741409.

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11

Opie, Shaun Rueben. "Characterization of mutations in the terminal repeats and capsid proteins of the adeno-associated virus type-2." [Gainesville, Fla.]: University of Florida, 2003. http://purl.fcla.edu/fcla/etd/UFE0000761.

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12

Cazaux, Benoite. "Approche cytogénomique de l'évolution des séquences répétées : cas des satellites et des gènes ribosomiques au sein du genre Mus." Thesis, Montpellier 2, 2011. http://www.theses.fr/2011MON20099/document.

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L'étude comparative de l'architecture des génomes mammaliens a révélé l'association des séquences répétées et des réarrangements. Cette thèse porte sur la dynamique et le rôle dans les remaniements de deux types de séquences répétées: les clusters ribosomiques et les satellites. Ces séquences sont analysées par une approche cytogénomique (FISH, CO-FISH) dans le genre Mus connu pour sa diversité chromosomique, et pour lequel les phylogénies moléculaires et chromosomiques sont disponibles.1) La distribution chromosomique des clusters ribosomiques, établie chez 19 espèces, a permis de reconstruir
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13

Jackson, Marion Louise. "Molecular detection and analysis of feline leukemia virus (FeLV) long terminal repeat (LTR) sequences in neoplastic and non-neoplastic FeLV-induced diseases of domestic cats." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1996. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/nq24060.pdf.

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14

Dušan, Vapa. "Varijabilnost mikrosatelitskih lokusa X hromozoma u populaciji Vojvodine." Phd thesis, Univerzitet u Novom Sadu, Medicinski fakultet u Novom Sadu, 2016. https://www.cris.uns.ac.rs/record.jsf?recordId=95598&source=NDLTD&language=en.

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Kratki uzastopni ponovci predstavljaju klasu mikrosatelitskih segmenata DNK, rasprostranjenih &scaron;irom genoma čoveka. Građeni su od uzastopno ponavljajućih sekvenci dužine 2-6 parova nukleotida. Zahvaljujući različitom broju ponavljanja repetitivne jedinice, većina mikrosatelitskih markera pokazuje visok stepen polimorfizma dužine, koji je moguće ispitati primenom tehnike lančane reakcije polimeraze. Pored utvrđivanja spornih srodničkih odnosa, analiza X hromozom mikrosatelitskih markera može se uspe&scaron;no koristiti i u oblastima kriminalistike, humane identifikacije, populaciono-genet
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15

Katti, M. V. "Analysis of simple sequence repeats in genome and protein sequences and development of computational tools for comparative promoter sequence analysis." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 2001. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/2323.

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16

Wilson, Lindsay Anne. "The enterobacterial repeated intergenic consensus (ERIC) sequence." Thesis, University of Nottingham, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.342441.

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17

Snook, Michael James. "Evolution of Tandemly Repeated Sequences." Thesis, University of Canterbury. Mathematics & Statistics, 2009. http://hdl.handle.net/10092/2661.

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Despite being found in all presently sequenced genomes, the evolution of tandemly repeated sequences has only just begun to be understood. We can represent the duplication history of tandemly repeated sequences with duplication trees. Most phylogenetic techniques need to be modified to be used on duplication trees. Due to gene loss, it is not always possible to reconstruct the duplication history of a tandemly repeated sequence. This thesis addresses this problem by providing a polynomial-time locally optimal algorithm to reconstruct the duplication history of a tandemly repeated sequence in
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18

Jacobs, L. "The transposition of sequences bounded by direct repeats." Thesis, University of Bristol, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.384449.

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19

Lee, Hong-seng Daniel, and 李康善. "Foldback DNA: nucleotide sequence and characterization of MboII repeated sequences in human long foldbackDNA by molecular cloning and hybridization." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1987. http://hub.hku.hk/bib/B31231251.

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20

Leonchiks, Ainars. "Regulation of protein degradation by virus derived repeated amino acid sequences /." Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-206-x/.

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21

Lee, David. "Repeated sequences in the pea genome." Thesis, University of East Anglia, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.290227.

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22

Lee, Hong-seng Daniel. "Foldback DNA : nucleotide sequence and characterization of MboII repeated sequences in human long foldback DNA by molecular cloning and hybridization /." [Hong Kong : University of Hong Kong], 1987. http://sunzi.lib.hku.hk/hkuto/record.jsp?B12263643.

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23

Pryde, Fiona E. "Function of subtelomeric repeat sequence in the yeast Saccharomyces cerevisiae." Thesis, University of Oxford, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.302603.

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24

Sun, Eileen Soomie. "Subfamily I Treponema pallidum repeat proteins : sequence variation and immunity /." Thesis, Connect to this title online; UW restricted, 2004. http://hdl.handle.net/1773/9305.

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25

Gray, Ian Christopher. "Polymorphic tandemly repeated sequences in human DNA." Thesis, University of Leicester, 1991. http://hdl.handle.net/2381/34415.

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Tandemly repeated tracts of DNA are a ubiquitous feature of eukaryote genomes. One class of tandem repeats, 'minisatellites', have been shown to be highly variable both in overall length and in the internal arrangement of variant versions of the repeating unit along the array. Consequently, both length and internal variation at these loci can be exploited to generate individual-specific profiles of use in forensic science and the establishment of family relationships. Recently it has been demonstrated that short dinucleotide repeats, or 'microsatellites', and other simple tandem repeat arrays
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26

Bolognini, Davide. "Unraveling tandem repeat variation in personal genomes with long reads." Doctoral thesis, Università di Siena, 2021. http://hdl.handle.net/11365/1141832.

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Tandem repeats are repeated sequences that occur adjacent to each other in the human genome. Due to their prevalence and their association with a number of genetic diseases, there is a rising interest in developing tools for tandem repeat profiling. Genome-wide discovery approaches are needed to fully understand their roles in health and disease but resolving tandem repeat variation accurately remains a very challenging task. Indeed, while traditional mapping-based and assembly-based approaches using short-read data have severe limitations in the size and type of tandem repeats they can
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27

Rae, Stephen J. "Isolation and characterisation of simple sequence repeat markers for Beta vulgaris." Thesis, University of Bristol, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.274669.

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28

Mann, Anita. "Structures and biological effects of repeated DNA sequences." Thesis, University of Kent, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.263749.

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29

Mileham, P. J. R. "Genomic organisation of a repeat sequence island on the mouse X chromosome." Thesis, Imperial College London, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.266356.

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30

Miranda, Rafael. "Sequence Specific RNA Recognition by Pentatricopeptide Repeat Proteins: Beyond the PPR Code." Thesis, University of Oregon, 2018. http://hdl.handle.net/1794/23135.

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Pentatricopeptide repeat (PPR) proteins are helical-repeat proteins that bind RNAs through a simple 1-repeat:1-nucleotide manner. Nucleotide specificity is determined by an amino acid code, the PPR code. This modular interaction mode, predictable code for nucleotide specificity, and simple repeating architecture make them a promising scaffold for engineering proteins to bind custom RNA sequences and binding site prediction of native PPR proteins. Despite these features, the alignments of the binding sites of well-characterized PPR proteins to the predicted binding sites often have mismatches a
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31

Mahmoud, Ahmed Abd-Rabbou. "Characterization of repeated DNA sequences in diploid Thinopyrum species /." free to MU campus, to others for purchase, 2004. http://wwwlib.umi.com/cr/mo/fullcit?p3144438.

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32

Chenkov, Nikolay. "Network mechanisms underlying sharp wave ripples and memory replay." Doctoral thesis, Humboldt-Universität zu Berlin, 2017. http://dx.doi.org/10.18452/18491.

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Komplexe Muster neuronaler Aktivität entstehen während der Sharp-wave Ripples (SWRs) im Hippocampus und während der Up States im Neokortex (Zuständen mit hoher Aktivität). Sequenzen von Verhalten, die in der Vergangenheit erlebt wurden, werden während des komplexen Musters abgespielt. Die zugrunde liegenden Mechanismen sind nicht gründlich erforscht: Wie können kleine synaptische Veränderungen die großflächige Netzwerkaktivität während des Gedächtnisabrufes und der Gedächtniskonsolidierung kontrollieren? Im ersten Teil dieser Abhandlung wird die Hypothese aufgestellt, dass eine schwac
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33

Jarvis, David. "Simple Sequence Repeat Development, Polymorphism and Genetic Mapping in Quinoa (Chenopodium quinoa Willd.)." Diss., CLICK HERE for online access, 2006. http://contentdm.lib.byu.edu/ETD/image/etd1475.pdf.

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34

Ledda, Alice. "Distribution and evolution of short sequence tandem repeats in eukariotic genomes." Doctoral thesis, Universitat Pompeu Fabra, 2011. http://hdl.handle.net/10803/31968.

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Els microsat el lits s on seq u encies d'ADN formades per repeticions en t andem de motius curts. Les curtes seq u encies repetides en t andem s on ubiq ues en els genomes dels eucariotes, tant en les regions codi cants com en les regions no codi cants. Aquestes seq u encies tenen un nivell molt elevat de polimor sme i de diverg encia interespec ca. Hem investigat si les dades obtingudes mitjan cant la seq uenciaci o de nova generaci o del Projecte Pilot dels 1000 Genomes s on utils per quanti car la variabilitat dels microsat el lits en les poblacions humanes i per descobrir nous l
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35

Burman, Marc. "Phylogeographic structure in the CFR genus Pauridia revealed by inter-simple sequence repeat amplification." Bachelor's thesis, University of Cape Town, 2005. http://hdl.handle.net/11427/26185.

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The Cape Floristic Region, South Africa, has high numbers of rare and endemic plants. Many, including Pauridia Harv., are geophytes in the Hypoxidaceae. The two species of Pauridia differ in morphology and range, with P. minuta occupying a wide range across lowland CFR and P. longituba being restricted to granite outcrops on the West coast. Genetic structure correlated to geography has been described for the haploid chloroplast genome. Here the diploid nuclear genome is investigated using inter-simple sequence repeat amplification. Eleven populations were sampled from DNA collected for a previ
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36

Zimmerman, Peter Allen. "The evolution of a repeated DNA sequence can be used to classify Onchocerca." Case Western Reserve University School of Graduate Studies / OhioLINK, 1992. http://rave.ohiolink.edu/etdc/view?acc_num=case1056550224.

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37

Rafferty, Joseph A. "A study of repeated DNA sequences in the orthopteran Stauroderus scalaris." Thesis, Queen's University Belfast, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.356926.

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38

Oskarsson, An Thuy. "What's next? Judging sequences of repeated binary events: An explanation-based approach." Diss., Connect to online resource, 2006. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3219038.

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39

York, William A. "Re-examining subfamily classifications for the alu family of repeated dna sequences." Master's thesis, University of Central Florida, 1994. http://digital.library.ucf.edu/cdm/ref/collection/RTD/id/24455.

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University of Central Florida College of Arts and Sciences Thesis<br>The primate Alu family of repetitive elements has been wedely characterized. This ubiquitous class of retroposons has been found to occupy some 5% of the human genome. This hetergenous group of Short Interspersed Nucleic acid Elements (SINEs) has been theorized to possess an identifiable subfamily structure between and within various taxonomic levels in promates. It has been postulated that humans possess up to 6 Alu sequences and found evidence supporting the amplification/fixation theory in 5 subfamilies. The research p
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40

Gradit, Sébastien. "Using statistical profiling to decipher hidden chromatin contacts resulting from repeated sequences." Electronic Thesis or Diss., Sorbonne université, 2024. http://www.theses.fr/2024SORUS494.

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Les génomes ne sont pas des entités statiques ; ils évoluent et acquièrent divers éléments répétés tels que des rétrotransposons, des gènes dupliqués et des répétitions en tandem. Ces éléments, bien que cruciaux pour la fonction et l'évolution du génome, posent un défi important à la génomique moderne en raison des limites des technologies de séquençage de nouvelle génération (NGS). Les technologies NGS produisent des lectures courtes qui ne peuvent être mises en correspondance sans ambiguïté avec les régions répétitives, ce qui a pour conséquence de les exclure de la plupart des analyses. Cet
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41

El, Soufi Karim. "Study of circular code motifs in nucleic acid sequences." Thesis, Strasbourg, 2017. http://www.theses.fr/2017STRAD004/document.

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Le travail effectué dans cette thèse présente une nouvelle approche de la théorie du code circulaire dans les gènes qui a été initiée en 1996. Cette approche consiste à analyser les motifs construits à partir de ce code circulaire, ces motifs particuliers sont appelés motifs de code circulaire. Ainsi, nous avons développé des algorithmes de recherche pour localiser les motifs de code circulaire dans les séquences d'acides nucléiques afin de leur trouver une signification bioinformatique. En effet, le code circulaire X identifie dans les gènes est un ensemble de trinucleotides qui a la propriét
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42

Alm, Kylie H. "Hippocampal Representations of Targeted Memory Reactivation and Reactivated Temporal Sequences." Diss., Temple University Libraries, 2017. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/422606.

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Psychology<br>Ph.D.<br>Why are some memories easy to retrieve, while others are more difficult to access? Here, we tested whether we could bias memory replay, a process whereby newly learned information is reinforced by reinstating the neuronal patterns of activation that were present during learning, towards particular memory traces. The goal of this biasing is to strengthen some memory traces, making them more easily retrieved. To test this, participants were scanned during interleaved periods of encoding and rest. Throughout the encoding runs, participants learned triplets of images that we
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43

Swift, Paul. "Identification and analysis of simple sequence repeats and their role in contingency loci." Thesis, University of Oxford, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.504604.

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44

Ara, Andleeb. "Development of NASBA-primer search software for designing forensic saliva tandem repeat markers for mucin and amylase." Muncie, Ind. : Ball State University, 2009. http://cardinalscholar.bsu.edu/635.

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45

El, Soufi Karim. "Study of circular code motifs in nucleic acid sequences." Electronic Thesis or Diss., Strasbourg, 2017. http://www.theses.fr/2017STRAD004.

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Le travail effectué dans cette thèse présente une nouvelle approche de la théorie du code circulaire dans les gènes qui a été initiée en 1996. Cette approche consiste à analyser les motifs construits à partir de ce code circulaire, ces motifs particuliers sont appelés motifs de code circulaire. Ainsi, nous avons développé des algorithmes de recherche pour localiser les motifs de code circulaire dans les séquences d'acides nucléiques afin de leur trouver une signification bioinformatique. En effet, le code circulaire X identifie dans les gènes est un ensemble de trinucleotides qui a la propriét
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46

Chen, Chiung-Mei. "Investigating the functional consequences of expanded triplet repeat sequence in a mouse model of Huntington's Disease (HD)." Thesis, University of Glasgow, 2002. http://theses.gla.ac.uk/2114/.

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A PCR strategy showed that a number of total mtDNA molecules was significantly decreased (~30%) in the striatum (no reduction in the cortex and cerebellum) of 24-month old HD mice, but not a 15 months of age, when compared to wild-type mice, suggesting mtDNA depletion is a progressive rather than a developmental phenomenon. In light of the ~30% reduction of total mtDNA in the striatum, expression levels of the mitochondrial DNA-encoded respiratory complex enzymes, cytochrome b(Cytb), cytochrome c oxidase I (COI) and cytochrome c oxidase II (COII) were investigated in different brain regions of
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47

Wiktor-Brown, Dominika M. "The impact of age, exposure and genetics on homologous recombination at the engineered repeat sequence in mice." Thesis, Massachusetts Institute of Technology, 2007. http://hdl.handle.net/1721.1/39913.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Biological Engineering Division, 2007.<br>Includes bibliographical references.<br>Mitotic homologous recombination is a critical pathway for the repair of DNA double-strand breaks and broken replication forks. Although homologous recombination is generally error-free, recombination between misaligned sequences can lead to deleterious sequence rearrangements, and conditions that stimulate homologous recombination are associated with an increased risk of cancer. To study homologous recombination in vivo, we used Fluorescent Yellow Direct Re
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48

Myers, Shere Lynne. "Cellular Effects of Replicating a Polypurine-Polypyrimidine Sequence and the Interactions of DUE-B with Replication Proteins." Wright State University / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=wright1292507800.

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49

Arora, Vishal. "Characterization of Polymorphic Microsatellites in Strawberry and Their Transferability to Other Genera in the Rosaceae Family." Thesis, Virginia Tech, 2006. http://hdl.handle.net/10919/31320.

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We investigated the transferability of 20 Fragaria vesca microsatellite primer pairs to 13 Fragaria vesca accessions, six Fragaria species and ten commercially important species in Rosaceae. Genetic diversity studies were carried among 16 diploid Fragaria accessions using these polymorphic microsatellites. The average number of alleles amplified for a polymorphic locus was 4.7 with maximum being 8.0 and minimum being 3.0. Observed heterozygosity ranged from 0.00 to 0.84 with an average of 0.28. Expected heterozygosity ranged from 0.33 to 0.91 with an average of 0.76. Power of discrimination va
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CHEN, LI-GONG, and 陳立功. "Nucleotide sequence analysis of repeat sequences in Trichinella spiralis." Thesis, 1988. http://ndltd.ncl.edu.tw/handle/06616509374134425057.

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