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Journal articles on the topic 'Repeated dose toxicity'

Author: Grafiati

Published: 4 June 2021

Last updated: 15 February 2022

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1

Mandal, TK, S. Das, S. Manna, and D. Bhattacharyya. "Repeated dose toxicity of deltamethrin in rats." Indian Journal of Pharmacology 37, no. 3 (2005): 160. http://dx.doi.org/10.4103/0253-7613.16212.

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2

Johnson, K. A., M. D. Dryzga, K. J. Brooks, E. W. Carney, B. Tornesi, and W. T. Stott. "Repeated dose toxicity and developmental toxicity of diisopropanolamine to rats." Food and Chemical Toxicology 45, no. 10 (2007): 1838–45. http://dx.doi.org/10.1016/j.fct.2007.03.019.

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3

Manna, S., D. Bhattacharyya, T. K. Mandal, and S. Das. "Repeated dose toxicity of alfa-cypermethrin in rats." Journal of Veterinary Science 5, no. 3 (2004): 241. http://dx.doi.org/10.4142/jvs.2004.5.3.241.

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4

Kiss, Tivadar, Andrea Szabó, Gábor Oszlánczi, et al. "Repeated-dose toxicity of common ragweed on rats." PLOS ONE 12, no. 5 (2017): e0176818. http://dx.doi.org/10.1371/journal.pone.0176818.

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5

Marrs, T. C., H. F. Colgrave, J. A. G. Edginton, and N. L. Cross. "Repeated dose inhalation toxicity of cinnamic acid smoke." Journal of Hazardous Materials 21, no. 1 (1989): 1–13. http://dx.doi.org/10.1016/0304-3894(89)85073-3.

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6

de Almeida, Tielle Moraes, Gilsane Lino von Poser, Liz Girardi Müller, et al. "Oral Acute and Repeated-Doses Toxicity Study of Valepotriates from Valeriana glechomifolia (Meyer) in Mice." Current Drug Discovery Technologies 16, no. 1 (2019): 96–103. http://dx.doi.org/10.2174/1570163815666180629164332.

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Background:Species of Valeriana show sedative, hypnotic, anxiolytic, antidepressant and anti-inflammatory properties, which are associated with valepotriates. However, data about toxicity and safety of these compounds are still limited. The aim of this study was to investigate the toxicity of a valepotriate-enriched fraction (VAL) from Valeriana glechomifolia Meyer based on the Organization for Economic Cooperation and Development (OECD) guidelines 423 and 407.Methods:In the acute study, CF1 mice were treated with a single dose of VAL (2000 mg/kg, p.o.) and observed for 14 days. In the repeate

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7

Woo, Sang Ha, Jung Hee Lee, Cho-in Lee, Yun Kyu Lee, Hyun-Jong Lee, and Jae Soo Kim. "Single-dose and 4-week repeated dose Toxicity of Aconitum Sinomontanum Nakai Pharmacopuncture: An Experimental Study." Journal of Acupuncture Research 38, no. 1 (2021): 47–59. http://dx.doi.org/10.13045/jar.2020.00332.

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Background: This study aimed to assess the toxicity of Aconitum sinomontanum Nakai (ASN) pharmacopuncture.Methods: To investigate the toxicity of ASN pharmacopuncture, single and 4-week repeated dose toxicity experiments were conducted on BALB/c mice. In the single-dose toxicity experiment, mice were assigned 1 of 4 groups (5 males, 5 females per group). Then, 31.25, 62.5, and 125 mg/kg of ASN pharmacopuncture were administered to the mice in the experimental groups at acupoint ST36, while 0.2 mL of normal saline was administered to the control group at ST36. After a 4-week repeated dose regim

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8

Lee, Hae-June, and Yun-Sil Lee. "Repeated-dose toxicity of HSP27-binding heptapeptide in mice." Drug and Chemical Toxicology 33, no. 3 (2010): 284–90. http://dx.doi.org/10.3109/01480540903483425.

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9

Briggs, Katharine. "P24: Maximising the value of repeated dose toxicity data." Experimental and Toxicologic Pathology 61, no. 4 (2009): 412. http://dx.doi.org/10.1016/j.etp.2009.02.107.

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10

NAKAMURA, Shozo, Takahiro SANZEN, Shigehito NAKAGAWA, et al. "SINGLE-DOSE TOXICITY STUDY AND TWENTYEIGHT-DAYS INTRAVENOUSLY REPEATED DOSE TOXICITY STUDY OF DESETHYL-PIPERACILLIN IN RATS." Journal of Toxicological Sciences 19, SupplementII (1994): 281–94. http://dx.doi.org/10.2131/jts.19.supplementii_281.

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11

Rojas-Armas, Juan Pedro, Jorge Luis Arroyo-Acevedo, José Manuel Ortiz-Sánchez, et al. "Potential Toxicity of the Essential Oil from Minthostachys mollis: A Medicinal Plant Commonly Used in the Traditional Andean Medicine in Peru." Journal of Toxicology 2019 (December 19, 2019): 1–9. http://dx.doi.org/10.1155/2019/1987935.

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Medicinal plants are used throughout the world and the World Health Organization supports its use by recommending quality, safety and efficacy. Minthostachys mollis is distributed in the Andes of South America and is used by the population for various diseases. While studies have shown their pharmacological properties, the information about their safety is very limited. Then, the goal of this research was to determine the acute oral toxicity and in repeated doses during 28 days of Minthostachys mollis essential oil (Mm-EO) in rats. For the acute toxicity test two groups of rats, of three anima

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12

Kobayashi, Katsumi, Kalathil Sadasivan Pillai, Mathews Michael, Kotturathu Mammen Cherian, Akihiro Araki, and Akihiko Hirose. "Determination of dose dependence in repeated dose toxicity studies when mid-dose alone is insignificant." Journal of Toxicological Sciences 37, no. 2 (2012): 255–60. http://dx.doi.org/10.2131/jts.37.255.

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13

Hong, Hyun Sook, Sung Vin Lim, and Youngsook Son. "Evaluation of substance-P toxicity with single dose and repeated dose in rats." Molecular & Cellular Toxicology 11, no. 2 (2015): 201–11. http://dx.doi.org/10.1007/s13273-015-0019-1.

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14

Kinkead, Edwin R., Susan K. Bunger, Robin E. Wolfe, Carlyle D. Flemming, Richard E. Whitmire, and Henry G. Wall. "Repeated-Dose Gavage Studies on Polychlorotrifluoroethylene Acids." Toxicology and Industrial Health 7, no. 4 (1991): 295–307. http://dx.doi.org/10.1177/074823379100700405.

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C8 polychlorotrifluoroethylene (pCTFE) oligomers accumulate preferentially in the liver during long-term oral exposure and appear to be more hepatotoxic than C6 oligomers. A repeated-dose gavage study was initiated to determine the relative contributions of the corresponding C6 (trimer) and C8 (tetramer) acid metabolites to the toxicity of pCTFE in the male Fischer 344 rat. Test animals were dosed once per week for various time periods up to one year. A depression (p < 0.05) in mean body weight occurred in the highest dose tetramer acid (2.16 mg/kg) group. An increase in hepatic peroxisomal

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15

Ceriani, Lidia, Arianna Bassan, Andrea Gissi, et al. "Development of an ECHA structured database on repeated dose toxicity." Toxicology Letters 280 (October 2017): S302. http://dx.doi.org/10.1016/j.toxlet.2017.07.845.

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16

Ezzalfani, M., V. Yin, and S. Mandrekar. "Dose-finding design with repeated continuous toxicity and efficacy data." Revue d'Épidémiologie et de Santé Publique 66 (May 2018): S132. http://dx.doi.org/10.1016/j.respe.2018.03.337.

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17

Lent, Emily May, Lee C. B. Crouse, Michael J. Quinn, and Shannon M. Wallace. "Comparison of the Repeated Dose Toxicity of Isomers of Dinitrotoluene." International Journal of Toxicology 31, no. 2 (2012): 143–57. http://dx.doi.org/10.1177/1091581811434645.

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Dinitrotoluene (DNT) is a nitroaromatic explosive used in propellant mixtures and in the production of plastics. Isomers of DNT were administered daily via oral gavage to male Sprague-Dawley rats for 14 days to determine the subacute toxicity of individual isomers of DNT. The 3,5-DNT isomer was the most toxic isomer, inducing weight loss and mortality within 3 days. Cyanosis and anemia were observed for all isomers. Exposure to 2,4-, 2,6-, and 3,5-DNT resulted in decreased testes mass and degenerative histopathological changes. Increased splenic mass was observed for 2,4-, 2,6-, and 2,5-DNT. E

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18

Marrs, T. C., H. F. Colgrave, J. A. G. Edginton, R. F. R. Brown, and N. L. Cross. "The repeated dose toxicity of a zinc oxide/hexachloroethane smoke." Archives of Toxicology 62, no. 2-3 (1988): 123–32. http://dx.doi.org/10.1007/bf00570130.

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19

López, Yulieé, Marta Pastor, Juan Francisco Infante, et al. "Repeated dose toxicity study ofVibrio cholerae-loaded gastro-resistant microparticles." Journal of Microencapsulation 31, no. 1 (2013): 86–92. http://dx.doi.org/10.3109/02652048.2013.808278.

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20

Rakitskii, Valery N., E. G. Chkhvirkiya, and T. M. Epishina. "The toxicity of the technical product, derived triazolinones." Health Care of the Russian Federation 64, no. 2 (2020): 83–87. http://dx.doi.org/10.46563/0044-197x-2020-64-2-83-87.

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Introduction. Technical products that are part of pesticides recommended for use in agriculture must undergo a comprehensive sanitary and Toxicological examination, which is the basis for preventing the adverse effects of pesticides on the health of workers and the population, as well as on the sanitary state of the environment. Purpose of research - the study of the biological effect of the technical product derived triazolinthionov, with its repeated oral intake in mammals (rats), justification of the permissible daily dose (DSD) for humans. Material and methods. Chronic (12 months) experime

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21

Sharma, Ganesh N., Shaili Rasania, Paresh Dadhaniya, Chintan Patel, and Kapil Vachhani. "Assesment of 28 days repeated adminstration toxicity profile of dexamethasone palmitate injection." Journal of Nepal Pharmaceutical Association 27, no. 1 (2015): 9–19. http://dx.doi.org/10.3126/jnpa.v27i1.12145.

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Although, the dexamethasone have been used for the managements, against various ailments as single API or in combination with other drugs as acetate or palmitate salt. However, Dexamethasone as palmitate salt has not been investigated so far for sub acute toxicity on intravenous administration. Therefore, an attempt has been made to investigate sub-acute toxicity of dexamethasone palmitate injection. The drug was administered in experimental animals at different dose levels (0.07, 0.18 and 0.44 mg/kg, b.w.), for 28 days, and alteration in biochemical and haematological parameters was recorded

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22

Jang, Jongwon, Wookcheol Seo, Hongmin Chu, et al. "Repeated-Dose Toxicity Testing of Scolopendrid Pharmacopuncture in Sprague-Dawley Rats." Journal of Acupuncture Research 37, no. 2 (2020): 110–17. http://dx.doi.org/10.13045/jar.2020.00059.

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Background: The aim of this pilot study was to assess the safety and dosing of scolopendrid pharmacopuncture (SPP).Methods: A total of 40 healthy Sprague-Dawley rats (males and 20 females 20) were selected following a 7-day inspection and acclimation period. SPP was administered via intramuscular injection, over a 2-week period using 3 doses including a high-dose [0.84 mg of scolopendrid per kg of body weight (BW)], a meddose (0.42 mg/kg BW), and a low-dose (0.21 mg/kg BW). The control group was injected with sterile water into the muscles. Unusual changes caused by administration of the test

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23

Kim, Keun-Su, Sung-Min Park, Nam-Jin Lee, et al. "Single-Dose Toxicity and Four Week Repeated-Dose Toxicity Study on Tensolin-F® (3,9-diferuloyl-6-oxopterocarpen)." Toxicological Research 23, no. 4 (2007): 405–13. http://dx.doi.org/10.5487/tr.2007.23.4.405.

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24

Lee, Yong Eun, Jung Hee Lee, Yun Kyu Lee, Bong Hyo Lee, Jae Soo Kim, and Hyun-Jong Lee. "A Study on Single-dose Toxicity and Repeated-Dose Toxicity of Drosera Rotundifolia L. Pharmacopuncture in Rodent Models." Korean Journal of Acupuncture 36, no. 2 (2019): 127–38. http://dx.doi.org/10.14406/acu.2019.013.

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25

Karbovskyi, V. L., I. A. Shevchuk, O. V. Kurkina, and T. Ye Makovska. "Study of PEG-Filstim sub-acute toxicity." Farmatsevtychnyi zhurnal, no. 2 (August 14, 2018): 77–86. http://dx.doi.org/10.32352/0367-3057.2.17.10.

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Febrile neutropenia caused by cytostatic therapy in the treatment of oncological diseases is a frequent complication, which results in enforced reduction in chemotherapy doses and lower effectiveness of the treatment. Introduction of the recombinant forms of the natural protein granulocyte colony-stimulating factor into clinical practice has allowed to minimize the negative consequences of myelosuppressive therapies. The main task of repeated dose toxicity studies of drugs is evaluation of damaging effects of the pharmacological substance, revealing the most sensitive organs and systems in the

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26

HAYASHI, Taiji, Shuji YAMAGUCHI, Suguru KITO, Gotaro TANAKA, Kyoko KUROKAWA, and Tomio HIROTA. "AN ORAL REPEATED DOSE TOXICITY STUDY OF A NEW ANTINEOPLASTIC AGENT S-1 IN DOGS : I. A 13-WEEK REPEATED DOSE TOXICITY STUDY, II. AN OPHTHALMOLOGIC TOXICITY RECOVERY STUDY." Journal of Toxicological Sciences 21, SupplementIII (1996): 527–44. http://dx.doi.org/10.2131/jts.21.supplementiii_527.

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27

Altzerinakou, Maria-Athina, and Xavier Paoletti. "An adaptive design for the identification of the optimal dose using joint modeling of continuous repeated biomarker measurements and time-to-toxicity in phase I/II clinical trials in oncology." Statistical Methods in Medical Research 29, no. 2 (2019): 508–21. http://dx.doi.org/10.1177/0962280219837737.

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We present a new adaptive dose-finding method, based on a joint modeling of longitudinal continuous biomarker activity measurements and time to first dose limiting toxicity, with a shared random effect. Estimation relies on likelihood that does not require approximation, an important property in the context of small sample sizes, typical of phase I/II trials. We address the important case of missing at random data that stem from unacceptable toxicity, lack of activity and rapid deterioration of phase I patients. The objective is to determine the lowest dose within a range of highly active dose

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28

Roh, Hang-Sik, Ji-Hyun Seok, Ja-Young Jeong, et al. "Repeated Dose Oral Toxicity Study of Alismatis Rhizoma in SD Rats." Journal of Korean Oriental Medical Ophthalmology and Otolaryngology and Dermatology 27, no. 1 (2014): 79–90. http://dx.doi.org/10.6114/jkood.2014.27.1.079.

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29

Hirata-Koizumi, Mutsuko, Sakiko Fujii, Masatoshi Furukawa, Atsushi Ono, and Akihiko Hirose. "Repeated dose and reproductive/developmental toxicity of perfluorooctadecanoic acid in rats." Journal of Toxicological Sciences 37, no. 1 (2012): 63–79. http://dx.doi.org/10.2131/jts.37.63.

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30

Takahashi, Mika, Shigeru Ishida, Mutsuko Hirata-Koizumi, Atsushi Ono, and Akihiko Hirose. "Repeated dose and reproductive/developmental toxicity of perfluoroundecanoic acid in rats." Journal of Toxicological Sciences 39, no. 1 (2014): 97–108. http://dx.doi.org/10.2131/jts.39.97.

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31

Jamadagni, PallaviS, ShrirangB Jamadagni, Rajendrakumar Singh, Sachchidanand Upadhyay, SudeshN Gaidhani, and Jayram Hazra. "Repeated dose oral toxicity of Trivanga Bhasma in Swiss albino mice." AYU (An International Quarterly Journal of Research in Ayurveda) 34, no. 1 (2013): 118. http://dx.doi.org/10.4103/0974-8520.115449.

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32

Jonsson, Martina, Janne Atosuo, Marika Jestoi, et al. "Repeated dose 28-day oral toxicity study of moniliformin in rats." Toxicology Letters 233, no. 1 (2015): 38–44. http://dx.doi.org/10.1016/j.toxlet.2014.11.006.

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33

Ji, Ho, Seong Jin Baek, and Deok Soo Moon. "Repeated Dose Toxicity Test Using Rats of Deep Sea Mineral Extract." Journal of the Korean Society for Marine Environment & Energy 23, no. 4 (2020): 210–15. http://dx.doi.org/10.7846/jkosmee.2020.23.4.210.

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34

Kawamata, Yasuko, Yusuke Shibui, Asuka Takumi, et al. "Genotoxicity and repeated-dose toxicity evaluation of dried Wolffia globosa Mankai." Toxicology Reports 7 (2020): 1233–41. http://dx.doi.org/10.1016/j.toxrep.2020.09.006.

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35

Deyno, Serawit, Mesfin Asefa Tola, Joel Bazira, Eyasu Makonnen, and Paul E. Alele. "Acute and repeated-dose toxicity of Echinops kebericho Mesfin essential oil." Toxicology Reports 8 (2021): 131–38. http://dx.doi.org/10.1016/j.toxrep.2020.12.027.

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36

Jeong-Hwan, Che, Kim Seung-Hyun, Cho Eun-Young, et al. "Single and repeated oral dose toxicity studies of titanium dioxide nanoparticles." Toxicology Letters 211 (June 2012): S198. http://dx.doi.org/10.1016/j.toxlet.2012.03.713.

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37

Schultz, Terry W., and Mark T. D. Cronin. "Lessons learned from read-across case studies for repeated-dose toxicity." Regulatory Toxicology and Pharmacology 88 (August 2017): 185–91. http://dx.doi.org/10.1016/j.yrtph.2017.06.011.

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38

Yerramilli-Rao, Padmaja, M. Flint Beal, Dai Watanabe, et al. "Oral Repeated-Dose Toxicity Studies of Coenzyme Q10 in Beagle Dogs." International Journal of Toxicology 31, no. 1 (2012): 58–69. http://dx.doi.org/10.1177/1091581811425256.

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To support phase III testing of coenzyme Q10 (CoQ10) in humans, we conducted pharmacokinetic and toxicology studies in beagle dogs. Following single gavage administration of CoQ10 at 600, 1200, 1800, or 2400 mg/kg per d no obvious dose response was observed in maximum concentration ( Cmax) or area under the curve (AUC) versus time curve at the 3 highest dosages. In a repeated-dose study of CoQ10 at 600, 1200, 1800, or 2400 mg/kg per d for 4 weeks, CoQ10 reached steady state in plasma by 2 weeks at all dosages. Both Cmax and AUC increased with increasing dosage of CoQ10. The highest plasma leve

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39

Bitsch, A., S. Jacobi, C. Melber, U. Wahnschaffe, N. Simetska, and I. Mangelsdorf. "REPDOSE: A database on repeated dose toxicity studies of commercial chemicals." Toxicology Letters 164 (September 2006): S226. http://dx.doi.org/10.1016/j.toxlet.2006.07.129.

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40

MACDONALD, JOHN R., CYNTHIA L. COURTNEY, and DAVID G. PEGG. "Leucovorin Protection against Repeated Daily Dose Toxicity of Trimetrexate in Rats." Toxicological Sciences 21, no. 2 (1993): 244–52. http://dx.doi.org/10.1093/toxsci/21.2.244.

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41

Shaikh, Masud, Syed Shoeb Ahmed, Mohd Urooj, Uzma Viquar, Munawwar Husain Kazmi, and Gulam Mohammed Husain. "90-Days Repeated Dose Oral Toxicity Study on Majoon-e-Nisyan." International Journal of Pharmacology, Phytochemistry and Ethnomedicine 15 (May 2020): 22–33. http://dx.doi.org/10.18052/www.scipress.com/ijppe.15.22.

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Majoon-e-Nisyan (MJN) is a polyherbal semisolid compound formulation. Its description is present in various Unani literatures. It is used in Unani medicine for its therapeutic efficacy against amnesia. There is no report regarding its safety on long term administration. Therefore, toxicological evaluation of MJN is carried out in rats. Majoon-e-Nisyan was subjected to 90-days repeated oral dose toxicity studies as per OECD guide line 408. Wistar rats were treated at three dose levels i.e., 500, 1000 and 2000 mg/kg bw and one vehicle treated group. MJN and vehicle were orally administered daily

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42

MacDonald, J. "Leucovorin Protection against Repeated Daily Dose Toxicity of Trimetrexate in Rats." Fundamental and Applied Toxicology 21, no. 2 (1993): 244–52. http://dx.doi.org/10.1006/faat.1993.1095.

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43

Kato, Hina, Sakiko Fujii, Mika Takahashi, et al. "Repeated dose and reproductive/developmental toxicity of perfluorododecanoic acid in rats." Environmental Toxicology 30, no. 11 (2014): 1244–63. http://dx.doi.org/10.1002/tox.21996.

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44

Lu, Guo-Cai, Jia-Hong She, Hua Jiang, Zhi-Yuan Li, and Bo-Jun Yuan. "Sixty-day repeated dose toxicity of sinafloxacin in rats and dogs." Food and Chemical Toxicology 46, no. 2 (2008): 575–80. http://dx.doi.org/10.1016/j.fct.2007.08.044.

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45

Vanhaecke, Tamara, Marleen Pauwels, Mathieu Vinken, Liesbeth Ceelen, and Vera Rogiers. "Towards an integrated in vitro strategy for repeated dose toxicity testing." Archives of Toxicology 85, no. 5 (2011): 365–66. http://dx.doi.org/10.1007/s00204-011-0711-4.

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46

Kitano, M., K. Hosoe, N. Fukutomi, T. Hidaka, N. Imai, and M. Kawabe. "28-Day repeated dose toxicity study of dried microorganism in rats." Food and Chemical Toxicology 42, no. 11 (2004): 1817–24. http://dx.doi.org/10.1016/j.fct.2004.06.013.

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47

Park, Hwayong, Youn-Hwan Hwang, and Jin Yeul Ma. "Single, repeated dose toxicity and genotoxicity assessment of herb formula KIOM2012H." Integrative Medicine Research 6, no. 4 (2017): 361–71. http://dx.doi.org/10.1016/j.imr.2017.07.007.

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48

Matsumoto, Mariko, Sakiko Fujii, Nozomu Hirose, et al. "Repeated-dose and reproductive/developmental toxicity screening of polyoxymethylene in rats." Fundamental Toxicological Sciences 8, no. 4 (2021): 103–16. http://dx.doi.org/10.2131/fts.8.103.

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49

Hong, Jeong-Sup, Suhyon Kim, Sang Hee Lee, et al. "Combined repeated-dose toxicity study of silver nanoparticles with the reproduction/developmental toxicity screening test." Nanotoxicology 8, no. 4 (2013): 349–62. http://dx.doi.org/10.3109/17435390.2013.780108.

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50

ZHIPENG, Wang, Li MINGKAI, Cui SHUYU, et al. "TOXICITY OF COENZYME Q10: A REPORT OF 90-DAY REPEATED DOSE TOXICITY STUDY IN RATS." Journal of Toxicological Sciences 32, no. 5 (2007): 505–14. http://dx.doi.org/10.2131/jts.32.505.

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