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Journal articles on the topic 'Repertoire of roles'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Cubells Serra, Jenny, Pilar Albertín Carbó, and Andrea Calsamiglia. "Transitando por los espacios jurídico-penales: discursos sociales e implicaciones para la intervención en casos de violencia hacia la mujer." Acciones e Investigaciones Sociales, no. 28 (April 19, 2011): 79. http://dx.doi.org/10.26754/ojs_ais/ais.201028482.

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El artículo pretende valorar psicosocialmente las características del trato que se dispensa a las víctimas de violencia de género en la pareja dentro de las instituciones del ámbito jurídico-penal en Catalunya (España). Con este objetivo, analizamos las funciones y los efectos discursivos de las narraciones de los actores que han formado parte de nuestra investigación (jueces, fiscales, abogados, policía y las propias víctimas). Los datos se han recogido a través de la observación participante y entrevistas, y hemos utilizamos el análisis del discurso y más concretamente la identificación de l

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Werbińska, Dorota. "A teacher-in-context." Apples - Journal of Applied Language Studies 11, no. 2 (2017): 103–23. http://dx.doi.org/10.17011/apples/urn.201708233541.

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Although there is an increasing body of research on the formation/re-formation of language teacher identity, there are still contexts within the professional practice of language teachers that remain relatively unexplored. One such context is the oral examination situation undergone by language teachers in Poland as part of the procedure for professional promotion. During this examination, teachers are expected to present their work, taking the prescribed ministerial regulations as their reference point. As access to teacher identity can be obtained through teacher talk about themselves, the p

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Odintsova, Anastasiia. "Fairy Tale and Art Therapy as the Means of Enriching Personality Roles Repertoire." East European Journal of Psycholinguistics 1, no. 1 (2016): 158–66. https://doi.org/10.5281/zenodo.45884.

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<strong>Abstract.</strong> The structure of the author’s training program “The system of relations to the vital roles” is highlighted in the article. The program aims to develop the roles and the expansion of repertoire of roles of the individual. The training program was based on the author’s typology of vital roles. The typology of roles on the concept of individual life path is represented as a pair of constructs:  axiological-semantic – axiological-neutral role, consistent and inconsistent role, active and passive roles, sense-creative and sense-neut

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З.М., Мірошник. "РОЛЬОВА СТРУКТУРА ОСОБИСТОСТІ – СКЛАДОВА КОМПЕ-ТЕНТНОСТІ МАЙБУТНЬОГО ПРАКТИЧНОГО ПСИХОЛОГА". Вісник Харківського національного педагогічного університету імені Г.С. Сковороди "Психологія", № 52 (14 січня 2016): 243–50. https://doi.org/10.5281/zenodo.44738.

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 We analyzed the role of the individual as a part of the structure of competence of the future practical psychologist. It is proved that the role of the practical psychologist personality structure characterized by some specific associations lined out lists and repertoire of roles that enable interaction of different levels of personal qualities and characteristics of their dynamics.

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Asgharian, Hossein, Hamid Mirebrahim, Dilduz Telman, et al. "Abstract A008: Adaptive immune receptor repertoire characterization highlights the importance of interplay between B and T cells in disease progression." Clinical Cancer Research 30, no. 21_Supplement (2024): A008. http://dx.doi.org/10.1158/1557-3265.liqbiop24-a008.

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Abstract Understanding the adaptive immune system is integral to disease progression studies, development of diagnostic biomarkers, identification of therapeutic targets, and discerning varied treatment responses. Despite growing interest in profiling B and T cells in cancer research, the interaction between these cells and also the crucial roles of γδ T cells often go overlooked. In this research project, we explored the role of crucial yet frequently ignored γδ T cells in cancer research, using immune repertoire data from bladder cancer patients. We also studied the synergy between B and T c

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Wang, Chunlin, Jessica Alleyne, Qunying Yang, et al. "Breast cancer diagnosis by high throughput sequencing of T cell receptors from peripheral blood samples (TUM2P.905)." Journal of Immunology 192, no. 1_Supplement (2014): 71.29. http://dx.doi.org/10.4049/jimmunol.192.supp.71.29.

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Abstract T cells play vital roles in the identification and elimination of transformed cells. It might be possible to diagnose cancer by reading imprints on the immune system made by cancer cells. High-throughput immune repertoire sequencing allows the depiction of T cell repertoire details at a nucleotide resolution and enables us to search for cancer-specific biomarkers. RNA was isolated from whole blood in breast cancer and matched controls and the CDR3 region of the TCR beta chain amplified and sequenced by Illumina next-generation sequencing platform. Initial studies showed around 200 bre

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Watanabe, Masashi, Michael Breen, Farrah Alkhaleel, and Richard J. Hodes. "Unique roles of TECs, DCs and B cells in Treg repertoire formation." Journal of Immunology 198, no. 1_Supplement (2017): 144.1. http://dx.doi.org/10.4049/jimmunol.198.supp.144.1.

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Abstract Foxp3+ CD4+ regulatory T cells (Treg) are an essential component in maintenance of immunological tolerance against self. Treg are generated in the thymus by relatively strong TCR recognition of self-peptide-MHCII complex (pMHCII) on antigen presenting cells (APCs). In addition to pMHCII dependent TCR signaling, B7 expression on APC is critical for Treg generation through CD28 co-stimulation. APCs that might be capable of providing such TCR/CD28 signaling to developing thymocytes include thymic epithelial cells (TECs), dendritic cells (DCs) and B cells. To date, however, how each APC c

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Isacchini, Giulio, Aleksandra M. Walczak, Thierry Mora, and Armita Nourmohammad. "Deep generative selection models of T and B cell receptor repertoires with soNNia." Proceedings of the National Academy of Sciences 118, no. 14 (2021): e2023141118. http://dx.doi.org/10.1073/pnas.2023141118.

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Subclasses of lymphocytes carry different functional roles to work together and produce an immune response and lasting immunity. Additionally to these functional roles, T and B cell lymphocytes rely on the diversity of their receptor chains to recognize different pathogens. The lymphocyte subclasses emerge from common ancestors generated with the same diversity of receptors during selection processes. Here, we leverage biophysical models of receptor generation with machine learning models of selection to identify specific sequence features characteristic of functional lymphocyte repertoires an

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Dai, Yang D., Kent P. Jensen, Idania Marrero, Ningli Li, Anthony Quinn, and Eli Sercarz. "Distinct Processing Patterns Involving Flanking Residues of a GAD65 Peptide Can Be Accountable for the Difference in Diabetes Susceptibility Between NOD and NOR Mice (B77)." Journal of Immunology 178, no. 1_Supplement (2007): LB16. http://dx.doi.org/10.4049/jimmunol.178.supp.b77.

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Abstract An immunogenic peptide in the GAD65 molecule, p524–543, activates two distinct populations of T cells, which apparently play opposite roles in the development of diabetes in NOD mice. In this study, we compared the fine specificity of these two T-cell repertoires using a nested set of truncated peptides that cover the p524–543 region. Surprisingly, we found that all clones apparently required the same minimum core sequence, around p530–539, for optimal activation. It was the flanking residues surrounding this core that played the crucial role in selecting T cells to activate. Flanking

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Kaffashi, Kimia, Didier Dréau, and Irina V. Nesmelova. "Heterodimers Are an Integral Component of Chemokine Signaling Repertoire." International Journal of Molecular Sciences 24, no. 14 (2023): 11639. http://dx.doi.org/10.3390/ijms241411639.

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Chemokines are a family of signaling proteins that play a crucial role in cell–cell communication, cell migration, and cell trafficking, particularly leukocytes, under both normal and pathological conditions. The oligomerization state of chemokines influences their biological activity. The heterooligomerization occurs when multiple chemokines spatially and temporally co-localize, and it can significantly affect cellular responses. Recently, obligate heterodimers have emerged as tools to investigate the activities and molecular mechanisms of chemokine heterodimers, providing valuable insights i

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Soloshchuk, Lyudmila, and Yuliia Skrynnik. "Variativity of the Speaker’s Verbal and Non-verbal Behavior in the English Managerial Discourse." PSYCHOLINGUISTICS 34, no. 2 (2023): 110–31. http://dx.doi.org/10.31470/2309-1797-2023-34-2-110-131.

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Introduction. This paper focuses on the study of the verbal and non-verbal repertoire of the speaker changing his/her social roles in the managerial type of discourse in the psycholinguistic perspective. The ambition of this analysis is to regard the strategies and tactics of the social roles’ performance with the detailed psycholinguistic analysis of the verbal and non-verbal repertoire of the speakers. Taking into account a speaker’s mental representations, sociolinguistic characteristics, interpreted as a speaker’s social status and roles, and the communicative situation itself, the researc

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Tylets, Valeriy G., Tat’yana M. Krasnyanskaya, and Aleksandr V. Lyakhov. "Repertory characteristics of role models of university students’ security." Vestnik of Kostroma State University. Series: Pedagogy. Psychology. Sociokinetics 26, no. 3 (2020): 129–35. http://dx.doi.org/10.34216/2073-1426-2020-26-3-129-135.

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The article discusses psychological issues of the role repertoire of university students in a situation of danger. Topicality of the problem is related to the wide range of threats a group may face, and its low scientific knowledge. The purpose of the research presented in the article is to study the nature of the distribution of roles in the group when solving security problems. The main research hypothesis is the assumption that the need to overcome danger may contribute to the repertory and functional specialisation of roles in the group caused by the fact and type of danger. Achieving this

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Chambers, Naomi, Judith Smith, Nathan Proudlove, Ruth Thorlby, Hannah Kendrick, and Russell Mannion. "Roles and behaviours of diligent and dynamic healthcare boards." Health Services Management Research 33, no. 2 (2019): 96–108. http://dx.doi.org/10.1177/0951484819887507.

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Variation persists in the quality of board-level leadership of hospitals. The consequences of poor leadership can be catastrophic for patients. The year 2019 marks 50 years of public inquiries into healthcare failures in the UK. The aim of this article is to enhance our understanding of context-specific effectiveness of healthcare board practices, drawing on an empirical study of changes in hospital board leadership in England. The study suggests leadership behaviours that lay the conditions for better organisation performance. We locate our findings within the wider theoretical debates about

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Pandey, Deepak, Ankit Roy Choudhury, Neeraj Kumar, and Sandeep Kumar. "Stem cell repertoire in the prostate epithelium." Journal of Stem Cell Research & Therapeutics 5, no. 2 (2019): 44–46. http://dx.doi.org/10.15406/jsrt.2019.05.00133.

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Over the past two decades, the roles of stem cells have been studied in the contexts of developmental biology, tissue engineering, cancer therapy, neurodegenerative disorders and what not! Right since the discovery of prostate specific adult stem cells or stem-like cells in both stromal and epithelial compartments, their participation in prostate development and prostatic pathologies (like benign prostatic hyperplasia and prostate cancer) are being thoroughly investigated. The present mini-review summarizes the ins and outs of the histological organization of acinar prostate and prostate cance

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Firkins, Christina, Michael Barrett-Berg, and Ina Fourie. "Information seeking behaviour in music conductors’ repertoire selection." Information Research an international electronic journal 29, no. 2 (2024): 275–301. http://dx.doi.org/10.47989/ir292827.

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Introduction. Music repertoire selection is a process driven by music conductors. They focus on scoring, ensemble composition, acquisition methods (i.e., acquiring the music). Information needs and seeking are core to repertoire selection and conductors’ tasks/roles. It cannot be considered in isolation; other conductor responsibilities, past experiences, and external factors (e.g., finances) influence the process and information seeking. We report findings from an exploratory study conducted in 2023 with 37 conductors. Method. Brief literature review, triangulated with findings from a mixed-m

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Trueblood, Lloyd A., Sarah Zylinski, Bruce H. Robison, and Brad A. Seibel. "An ethogram of the Humboldt squid Dosidicus gigas Orbigny (1835) as observed from remotely operated vehicles." Behaviour 152, no. 14 (2015): 1911–32. http://dx.doi.org/10.1163/1568539x-00003324.

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Many cephalopods can rapidly change their external appearance to produce multiple body patterns. Body patterns are composed of various components, which can include colouration, bioluminescence, skin texture, posture, and locomotion. Shallow water benthic cephalopods are renowned for their diverse and complex body pattern repertoires, which have been attributed to the complexity of their habitat. Comparatively little is known about the body pattern repertoires of open ocean cephalopods. Here we create an ethogram of body patterns for the pelagic squid, Dosidicus gigas. We used video recordings

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Abrams, Zsuzsanna Ittzes. "Computer-mediated communication and group journals: expanding the repertoire of participant roles." System 29, no. 4 (2001): 489–503. http://dx.doi.org/10.1016/s0346-251x(01)00041-0.

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Ring-Ramirez, Misty, Heidi Reynolds-Stenson, and Jennifer Earl. "Culturally Constrained Contention: Mapping the Meaning Structure of the Repertoire of Contention." Mobilization: An International Quarterly 19, no. 4 (2014): 405–19. http://dx.doi.org/10.17813/maiq.19.4.d972218lu6826510.

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While social network analysis (SNA) has traditionally been used to study actor networks, it can also reveal "meaning structures" (Mohr 1998), the relationships connecting cultural elements such as ideas and practices. We argue that the repertoire of contention represents a meaning structure, analyzable using SNA of tactical co-deployments at protests. We use data from over 7,000 protest events in New York State from 1960 to 1995. Our analyses suggest that co-deployed tactics are not chosen independently or combined randomly but rather cluster into sets with distinct roles. These roles reveal c

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Chang, Che-Mai, Yu-Wen Hsu, Henry Sung-Ching Wong, et al. "Characterization of T-Cell Receptor Repertoire in Patients with Rheumatoid Arthritis Receiving Biologic Therapies." Disease Markers 2019 (July 7, 2019): 1–12. http://dx.doi.org/10.1155/2019/2364943.

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Rheumatoid arthritis (RA) is a systematic autoimmune disease, predominantly causing chronic polyarticular inflammation and joint injury of patients. For the treatment of RA, biologic disease-modifying antirheumatic drugs (bDMARDs) have been used to reduce inflammation and to interfere with disease progression through targeting and mediating the immune system. Although the therapeutic effects of bDMARDs in RA patients have been widely reported, whether these drugs also play important roles in T-cell repertoire status is still unclear. We therefore designed the study to identify the role of T-ce

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Yawata, Makoto, Nobuyo Yawata, Monia Draghi, Ann-Margaret Little, Fotini Partheniou, and Peter Parham. "Roles for HLA and KIR polymorphisms in natural killer cell repertoire selection and modulation of effector function." Journal of Experimental Medicine 203, no. 3 (2006): 633–45. http://dx.doi.org/10.1084/jem.20051884.

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Interactions between killer cell immunoglobulin-like receptors (KIRs) and human leukocyte antigen (HLA) class I ligands regulate the development and response of human natural killer (NK) cells. Natural selection drove an allele-level group A KIR haplotype and the HLA-C1 ligand to unusually high frequency in the Japanese, who provide a particularly informative population for investigating the mechanisms by which KIR and HLA polymorphism influence NK cell repertoire and function. HLA class I ligands increase the frequencies of NK cells expressing cognate KIR, an effect modified by gene dose, KIR

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Ehsanzadeh, Seyed Jafar. "Depth versus Breadth of Lexical Repertoire: Assessing Their Roles in EFL Students’ Incidental Vocabulary Acquisition." TESL Canada Journal 29, no. 2 (2012): 24. http://dx.doi.org/10.18806/tesl.v29i2.1098.

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This study explores the roles of depth and breadth of lexical repertoire in L2 lexical inferencing success and incidental vocabulary acquisition through reading. Students read a graded reader containing 13 pseudo-words and attempted to infer the meanings of underlined target words. The Word Associates Test (WAT, Read, 2004) and the Vocabulary Levels Test (Schmitt, Schmitt, & Clapham, 2001) were administered to measure depth and breadth of lexical repertoire respectively. To rate retention of inferred meanings, I administered the Vocabulary Knowledge Scale (VKS, Paribakht & Wesche, 1996

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Hofmann, Stephanie. "Multilingualism and internationalisation in doctoral education: Discourse, positioning and agency." European Journal of Applied Linguistics 8, no. 2 (2020): 257–77. http://dx.doi.org/10.1515/eujal-2020-0009.

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AbstractDespite the growing linguistic and cultural diversity in higher education and research, little is known about how students and researchers use their plurilingual repertoire for writing and publishing. In particular, the roles of the national language(s) and the linguistic repertoire(s) vis-à-vis English as the lingua franca for academic writing and publishing have not been closely examined. This paper explores how doctoral researchers in Luxembourg position themselves in relation to macro-level discourses about language and academic success within their complex lingua-cultural and soci

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Chen, Si-Yi, Tao Yue, Qian Lei, and An-Yuan Guo. "TCRdb: a comprehensive database for T-cell receptor sequences with powerful search function." Nucleic Acids Research 49, no. D1 (2020): D468—D474. http://dx.doi.org/10.1093/nar/gkaa796.

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Abstract T cells and the T-cell receptor (TCR) repertoire play pivotal roles in immune response and immunotherapy. TCR sequencing (TCR-Seq) technology has enabled accurate profiling TCR repertoire and currently a large number of TCR-Seq data are available in public. Based on the urgent need to effectively re-use these data, we developed TCRdb, a comprehensive human TCR sequences database, by a uniform pipeline to characterize TCR sequences on TCR-Seq data. TCRdb contains more than 277 million highly reliable TCR sequences from over 8265 TCR-Seq samples across hundreds of tissues/clinical condi

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Yang, Chenjie, and Paul D. Robbins. "The Roles of Tumor-Derived Exosomes in Cancer Pathogenesis." Clinical and Developmental Immunology 2011 (2011): 1–11. http://dx.doi.org/10.1155/2011/842849.

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Exosomes are endosome-derived, 30–100 nm small membrane vesicles released by most cell types including tumor cells. They are enriched in a selective repertoire of proteins and nucleic acids from parental cells and are thought to be actively involved in conferring intercellular signals. Tumor-derived exosomes have been viewed as a source of tumor antigens that can be used to induce antitumor immune responses. However, tumor-derived exosomes also have been found to possess immunosuppressive properties and are able to facilitate tumor growth, metastasis, and the development of drug resistance. Th

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Lafreniere, Ben, Andrea Bunt, Matthew Lount, and Michael Terry. "Understanding the Roles and Uses of Web Tutorials." Proceedings of the International AAAI Conference on Web and Social Media 7, no. 1 (2021): 303–10. http://dx.doi.org/10.1609/icwsm.v7i1.14413.

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In this paper we identify roles and uses of web-based tutorials through an examination of tutorials’ comments sections. Through this analytical lens, we find that web tutorials serve a variety of needs, providing: in-task help for users with an immediate, specific goal to accomplish; a means for users to proactively expand their repertoire of skills; and an opportunity for novices to shadow and experience an expert’s work practices. We also find a number of emergent practices in tutorial comments. Users post “help-me” stack traces, a type of comment useful for debugging tutorial content; use c

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Taniguchi, Kaori, and Toru Miyazaki. "Putative roles of specific T cells in progression of obesity-associated inflammation in adipose tissue. (173.36)." Journal of Immunology 188, no. 1_Supplement (2012): 173.36. http://dx.doi.org/10.4049/jimmunol.188.supp.173.36.

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Abstract The metabolic syndrome is known as a chain of illness, triggered by obesity followed by diabetes, hepatic steatosis and atherosclerosis. It is well known that adipose tissues in obesity are in a state of chronic inflammation, and that such inflammatory state is tightly associated with multiple metabolic disorders. Accumulating evidence has shown that the inflammation is mainly lead by the recruitment of macrophages into adipose tissues. Although it has recently been suggested that T cells may also play a role in establishment of inflammation in adipose tissue during the early phase of

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Muhan, Ji. "Yang Xiinzi as a Representative of the Jin Telin Vocal and Performing School: Adapting the Principles of Bel Canto for the National Repertoire." Университетский научный журнал, no. 78 (February 16, 2024): 116–22. http://dx.doi.org/10.25807/22225064_2024_78_116.

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The article highlights the work of the Chinese singer Yang Xiinzi, who gained popularity as a performer of mainly national vocal repertoire. The article examines the creative path of the singer, especially noting the successive relation of her performing principles with the school of Jin Telin, an outstanding teacher who produced a whole galaxy of famous vocalists playing iconic roles in the panorama of modern vocal culture in China. Special attention is paid in the article to the adaptation of the principles of bel canto for the performance of the national Chinese repertoire, which, using the

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Colautti, Jake, Steven D. Kelly, and John C. Whitney. "Specialized killing across the domains of life by the type VI secretion systems of Pseudomonas aeruginosa." Biochemical Journal 482, no. 01 (2025): 1–15. https://doi.org/10.1042/bcj20230240.

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Type VI secretion systems (T6SSs) are widespread bacterial protein secretion machines that inject toxic effector proteins into nearby cells, thus facilitating both bacterial competition and virulence. Pseudomonas aeruginosa encodes three evolutionarily distinct T6SSs that each export a unique repertoire of effectors. Owing to its genetic tractability, P. aeruginosa has served as a model organism for molecular studies of the T6SS. However, P. aeruginosa is also an opportunistic pathogen and ubiquitous environmental organism that thrives in a wide range of habitats. Consequently, studies of its

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Dörner, Thomas, Hans-Peter Brezinschek, Sandra J. Foster, Ruth I. Brezinschek, Nancy L. Farner, and Peter E. Lipsky. "Delineation of Selective Influences Shaping the Mutated Expressed Human Ig Heavy Chain Repertoire." Journal of Immunology 160, no. 6 (1998): 2831–41. http://dx.doi.org/10.4049/jimmunol.160.6.2831.

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Abstract After Ag exposure, somatic hypermutation and subsequent selection play significant roles in shaping the peripheral B cell repertoire. However, the disparate impact of each process has not been completely delineated. To address this, the mutational patterns of a large panel of productive VHDJH rearrangements of individual human B cells were analyzed and compared with those of a previously reported panel of nonproductive VHDJH rearrangements. The productive VH rearrangements exhibited a significantly lower mutational frequency and a significantly smaller number of replacement mutations

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Younge, Bethany. "SEEING AND HEARING DISABILITY IN MAURICIO KAGEL'S REPERTOIRE FROM STAATSTHEATER." Tempo 75, no. 296 (2021): 7–20. http://dx.doi.org/10.1017/s0040298220000911.

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AbstractThis article adopts a disability studies perspective to evaluate the ways in which Mauricio Kagel's Repertoire from Staatstheater reimagines human bodies. Objects and bodies interact in myriad ways within the one hundred vignettes of Repertoire: some objects hinder or aid the bodies on stage, while others become incorporated within the body, acting as a single expressive unit. My analysis demonstrates the ways in which both objects and bodies transform their traditional roles as ascribed by society, rejecting procrustean physiques. Using disability studies concepts such as embodiment a

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Yu, Zizheng, Jiaxi Hou, and Oscar Tianyang Zhou. "Short Video Activism With and on Douyin: An Innovative Repertoire of Contention for Chinese Consumers." Social Media + Society 9, no. 1 (2023): 205630512311576. http://dx.doi.org/10.1177/20563051231157603.

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This article examines consumer video activism tactics in China and their impact on Chinese consumers and society. Drawing upon 56 semistructured interviews and a case study analysis of Chinese online consumer protest in 2018, we argue that short-video-activism tactics have become an innovative repertoire of contention for Chinese consumers and Douyin, the “sister app” of TikTok, has become a real-time updated database of this repertoire. Using Douyin as a case study, we argue that it plays three key roles in mediating Chinese consumer activism: a techno-cultural construct that affords highly h

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Callaghan, Martin J., Keith A. Jolley, and Martin C. J. Maiden. "Opacity-Associated Adhesin Repertoire in Hyperinvasive Neisseria meningitidis." Infection and Immunity 74, no. 9 (2006): 5085–94. http://dx.doi.org/10.1128/iai.00293-06.

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ABSTRACT The opacity (Opa) proteins mediate a variety of interactions between the bacterium Neisseria meningitidis and its human host. These interactions are thought to be of central importance in both the asymptomatic colonization of the nasopharynx and the sporadic occurrence of meningococcal disease. The receptor specificities of a limited number of Opa protein variants have been explored, but the high level of amino acid sequence diversity among variants has complicated the assignment of specific roles to individual Opa variants or combinations of variants. In addition, the distribution of

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Saulle, Irma, Chiara Vicentini, Mario Clerici, and Mara Biasin. "An Overview on ERAP Roles in Infectious Diseases." Cells 9, no. 3 (2020): 720. http://dx.doi.org/10.3390/cells9030720.

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Endoplasmic reticulum (ER) aminopeptidases ERAP1 and ERAP2 (ERAPs) are crucial enzymes shaping the major histocompatibility complex I (MHC I) immunopeptidome. In the ER, these enzymes cooperate in trimming the N-terminal residues from precursors peptides, so as to generate optimal-length antigens to fit into the MHC class I groove. Alteration or loss of ERAPs function significantly modify the repertoire of antigens presented by MHC I molecules, severely affecting the activation of both NK and CD8+ T cells. It is, therefore, conceivable that variations affecting the presentation of pathogen-der

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Reato, Francesca, Alessia Bresil, Chiara D’Angelo, et al. "Toward the Definition of a Repertoire of Technical Professional Specialist Competencies for Operating Room Nurses: An Ethnographic Study." Healthcare 12, no. 17 (2024): 1774. http://dx.doi.org/10.3390/healthcare12171774.

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Registered nurses in the operating room require specialized competencies that surpass basic educational training. Existing national and international documents attempt to outline these competencies but often lack comprehensive details. To address this, a repertoire of technical and professional competencies for operating room nurses, aligned with European and National Qualifications Frameworks, is proposed. Aim: Develop a repertoire of technical and professional competencies for perioperative and perianesthesiological specialist nursing roles. Methods: An at-home ethnography design was employe

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Mahlios, Josh M., and Yuan Zhuang. "Roles for Id3 in T Cell Development and Autoimmunity (48.17)." Journal of Immunology 182, no. 1_Supplement (2009): 48.17. http://dx.doi.org/10.4049/jimmunol.182.supp.48.17.

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Abstract T cell development is a tightly regulated process that requires a number of known transcription factors, one of which is Inhibitor of Differentiation 3 (Id3). Here we find that Id3 plays an important role during thymopoiesis by preventing the development of an autoimmune condition similar to that of primary Sjogren's Syndrome. In the absence of a functional Id3 protein, thymocyte development is dysregulated and leads to the production of T cells capable of inducing symptoms associated with Sjogren's Syndrome. The T cell repertoire is altered in a manner in which large numbers of γδ T

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Brovkina, Oksana, and Svitlana Baranova. "Role repertoire of the family discourse participants in a situation of frank communication: symmetric and asymmetric relations." Studies about Languages 1, no. 46 (2025): 63–79. https://doi.org/10.5755/j01.sal.1.46.37043.

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The article deals with the communicative situation of frank communication in the English family discourse from the point of view of the role repertoire of its participants. The role repertoire and addresser-addressee configuration of interactants of the English family discourse “HUSBAND-WIFE” affects the choice of communicative strategies and tactics, and the classification of roles is considered from the standpoint of symmetric/asymmetric relations of the speakers. The tactics of self-approval, overloading the perceiver with information, playing on feelings, self-expression, and the use of fl

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Yokosuka, Tadashi, Kan Takase, Misao Suzuki та ін. "Predominant Role of T Cell Receptor (TCR)-α Chain in Forming Preimmune TCR Repertoire Revealed by Clonal TCR Reconstitution System". Journal of Experimental Medicine 195, № 8 (2002): 991–1001. http://dx.doi.org/10.1084/jem.20010809.

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The CDR3 regions of T cell receptor (TCR)-α and -β chains play central roles in the recognition of antigen (Ag)-MHC complex. TCR repertoire is created on the basis of Ag recognition specificity by CDR3s. To analyze the potential spectrum of TCR-α and -β to exhibit Ag specificity and generate TCR repertoire, we established hundreds of TCR transfectants bearing a single TCR-α or -β chain derived from a cytotoxic T cell (CTL) clone, RT-1, specific for HIVgp160 peptide, and randomly picked up TCR-β or -α chains. Surprisingly, one-third of such TCR-β containing random CDR3β from naive T cells of no

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Ducker, Charles, and Peter E. Shaw. "Ubiquitin-Mediated Control of ETS Transcription Factors: Roles in Cancer and Development." International Journal of Molecular Sciences 22, no. 10 (2021): 5119. http://dx.doi.org/10.3390/ijms22105119.

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Genome expansion, whole genome and gene duplication events during metazoan evolution produced an extensive family of ETS genes whose members express transcription factors with a conserved winged helix-turn-helix DNA-binding domain. Unravelling their biological roles has proved challenging with functional redundancy manifest in overlapping expression patterns, a common consensus DNA-binding motif and responsiveness to mitogen-activated protein kinase signalling. Key determinants of the cellular repertoire of ETS proteins are their stability and turnover, controlled largely by the actions of sel

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Rakshambikai, R., S. Yamunadevi, K. Anamika, N. Tyagi, and N. Srinivasan. "Repertoire of Protein Kinases Encoded in the Genome ofTakifugu rubripes." Comparative and Functional Genomics 2012 (2012): 1–12. http://dx.doi.org/10.1155/2012/258284.

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Takifugu rubripesis teleost fish widely used in comparative genomics to understand the human system better due to its similarities both in number of genes and structure of genes. In this work we survey the fugu genome, and, using sensitive computational approaches, we identify the repertoire of putative protein kinases and classify them into groups and subfamilies. The fugu genome encodes 519 protein kinase-like sequences and this number of putative protein kinases is comparable closely to that of human. However, in spite of its similarities to human kinases at the group level, there are diffe

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Wan, Ying, Qingzhu Jia, Junfeng Zhou, et al. "Diversity index of mucosal resident T lymphocyte repertoire predicts clinical prognosis in gastric cancer (TUM7P.1028)." Journal of Immunology 194, no. 1_Supplement (2015): 142.17. http://dx.doi.org/10.4049/jimmunol.194.supp.142.17.

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Abstract A characteristic immunopathology of human cancers is the induction of tumor antigen-specific T lymphocyte responses within solid tumor tissues. Current strategies for immune monitoring focus on the quantification of the density and differentiation status of tumor-infiltrating T lymphocytes; however, properties of the TCR repertoire ‒ including antigen specificity, clonality, as well as its prognostic significance ‒ remain elusive. In this study, we enrolled 28 gastric cancer patients and collected tumor tissues, adjacent normal mucosal tissues, and peripheral blood samples to study th

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Scott, William A., Erum Z. Dhanji, Boris J. A. Dyakov, et al. "ATRX proximal protein associations boast roles beyond histone deposition." PLOS Genetics 17, no. 11 (2021): e1009909. http://dx.doi.org/10.1371/journal.pgen.1009909.

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The ATRX ATP-dependent chromatin remodelling/helicase protein associates with the DAXX histone chaperone to deposit histone H3.3 over repetitive DNA regions. Because ATRX-protein interactions impart functions, such as histone deposition, we used proximity-dependent biotinylation (BioID) to identify proximal associations for ATRX. The proteomic screen captured known interactors, such as DAXX, NBS1, and PML, but also identified a range of new associating proteins. To gauge the scope of their roles, we examined three novel ATRX-associating proteins that likely differed in function, and for which

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Schwarz-Plaschg, Claudia. "Nanotechnology is like … The rhetorical roles of analogies in public engagement." Public Understanding of Science 27, no. 2 (2016): 153–67. http://dx.doi.org/10.1177/0963662516655686.

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Lay people are increasingly invited to deliberate on emerging technologies in public engagement settings. Analogies appear frequently in these contexts and are commonly understood as means of making sense of and forming an opinion on emerging technologies. This article provides an alternative perspective, which conceptualizes analogies as rhetorical devices employed to achieve specific functions. A repertoire of rhetorical roles is traced in four public engagement settings on nanotechnology: (1) analogies suggesting acceptance/rejection of specific nano-applications, (2) anticipatory and alert

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Veríssimo, Carolina De Marco, Carlos Graeff-Teixeira, Malcolm K. Jones, and Alessandra L. Morassutti. "Glycans in the roles of parasitological diagnosis and host–parasite interplay." Parasitology 146, no. 10 (2019): 1217–32. http://dx.doi.org/10.1017/s0031182019000465.

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AbstractThe investigation of the glycan repertoire of several organisms has revealed a wide variation in terms of structures and abundance of glycan moieties. Among the parasites, it is possible to observe different sets of glycoconjugates across taxa and developmental stages within a species. The presence of distinct glycoconjugates throughout the life cycle of a parasite could relate to the ability of that organism to adapt and survive in different hosts and environments. Carbohydrates on the surface, and in excretory-secretory products of parasites, play essential roles in host–parasite int

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Rao, Sridhar, Shao Zhen, Sergei Roumiantsev, Lindsay T. McDonald, Guo-Cheng Yuan, and Stuart H. Orkin. "Differential Roles of Sall4 Isoforms in Embryonic Stem Cell Pluripotency." Molecular and Cellular Biology 30, no. 22 (2010): 5364–80. http://dx.doi.org/10.1128/mcb.00419-10.

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ABSTRACT Murine embryonic stem (ES) cells are defined by continuous self-renewal and pluripotency. A diverse repertoire of protein isoforms arising from alternative splicing is expressed in ES cells without defined biological roles. Sall4, a transcription factor essential for pluripotency, exists as two isoforms (Sall4a and Sall4b). Both isoforms can form homodimers and a heterodimer with each other, and each can interact with Nanog. By genomewide location analysis, we determined that Sall4a and Sall4b have overlapping, but not identical binding sites within the ES cell genome. In addition, Sa

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Fedortchenko, Olga. "Marius Petipa dans les ballets de Jules Perrot." Slavica Occitania 43, no. 1 (2016): 135–46. https://doi.org/10.3406/slaoc.2016.1077.

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Marius Petipa in the Ballets of Jules Perrot Marius Petipa danced in Saint Petersburg for over twenty years, from 1847 to 1869. His repertoire was colossal, but it was the ballets of Jules Perrot – Giselle, La Esmeralda, Faust, Le Corsaire, Le Diable à Quatre, etc. – which provided the mainstay of his performances. This paper examines press articles from the nineteenth century as a means of establishing an inventory of the different roles danced by Petipa, including both well-known (Phoebus, Faust, Conrad) and lesser known parts (Mitsislas in La Guerre des femmes or the principal male role in

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Barroso, Carolina, Pedro Carvalho, Carla Carvalho, et al. "The Diverse Piscidin Repertoire of the European Sea Bass (Dicentrarchus labrax): Molecular Characterization and Antimicrobial Activities." International Journal of Molecular Sciences 21, no. 13 (2020): 4613. http://dx.doi.org/10.3390/ijms21134613.

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Fish rely on their innate immune responses to cope with the challenging aquatic environment, with antimicrobial peptides (AMPs) being one of the first line of defenses. Piscidins are a group of fish specific AMPs isolated in several species. However, in the European sea bass (Dicentrarchus labrax), the piscidin family remains poorly understood. We identified six different piscidins in sea bass, performed an in-depth molecular characterization and evaluated their antimicrobial activities against several bacterial and parasitic pathogens. Sea bass piscidins present variable amino acid sequences

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Lockhead, Dean, Erich M. Schwarz, Robert O’Hagan, et al. "The tubulin repertoire of Caenorhabditis elegans sensory neurons and its context‑dependent role in process outgrowth." Molecular Biology of the Cell 27, no. 23 (2016): 3717–28. http://dx.doi.org/10.1091/mbc.e16-06-0473.

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Microtubules contribute to many cellular processes, including transport, signaling, and chromosome separation during cell division. They comprise αβ‑tubulin heterodimers arranged into linear protofilaments and assembled into tubes. Eukaryotes express multiple tubulin isoforms, and there has been a longstanding debate as to whether the isoforms are redundant or perform specialized roles as part of a tubulin code. Here we use the well‑characterized touch receptor neurons (TRNs) of Caenorhabditis elegans to investigate this question through genetic dissection of process outgrowth both in vivo and

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Turintseva, Alexandra B. "Camillo Everardi’s Pedagogical Repertoire at the Saint Petersburg Conservatory (1870–1888)." Contemporary Musicology 9, no. 1 (2025): 105–29. https://doi.org/10.56620/2587-9731-2025-1-105-129.

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This article, drawing on archival sources, attempts to reconstruct the pedagogical career of Camillo Everardi (1825–1899) at the Saint Petersburg Conservatory, where he taught for 18 years — from 1870 to 1888. For a long time, the primary reasons for his dismissal were believed to be his adherence to the traditions of the Italian and French vocal schools and their respective repertoires, his alleged “discrimination” against Russian music, his emphasis on opera at the expense of concert and chamber works, and, consequently, the purportedly inadequate preparation of his students for professional

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Lounici, Yasmine, Olivia Le Saux, Gabriel Chemin, et al. "Heterogeneity and Functions of Tumor-Infiltrating Antibody Secreting Cells: Lessons from Breast, Ovarian, and Other Solid Cancers." Cancers 14, no. 19 (2022): 4800. http://dx.doi.org/10.3390/cancers14194800.

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Neglected for a long time in cancer, B cells and ASCs have recently emerged as critical actors in the tumor microenvironment, with important roles in shaping the antitumor immune response. ASCs indeed exert a major influence on tumor growth, patient survival, and response to therapies. The mechanisms underlying their pro- vs. anti-tumor roles are beginning to be elucidated, revealing the contributions of their secreted antibodies as well as of their emerging noncanonical functions. Here, concentrating mostly on ovarian and breast cancers, we summarize the current knowledge on the heterogeneity

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Stastna, Miroslava. "Proteomics as a Tool for the Study of Mitochondrial Proteome, Its Dysfunctionality and Pathological Consequences in Cardiovascular Diseases." International Journal of Molecular Sciences 24, no. 5 (2023): 4692. http://dx.doi.org/10.3390/ijms24054692.

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The focus of this review is on the proteomic approaches applied to the study of the qualitative/quantitative changes in mitochondrial proteins that are related to impaired mitochondrial function and consequently different types of pathologies. Proteomic techniques developed in recent years have created a powerful tool for the characterization of both static and dynamic proteomes. They can detect protein–protein interactions and a broad repertoire of post-translation modifications that play pivotal roles in mitochondrial regulation, maintenance and proper function. Based on accumulated proteomi

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