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Dissertations / Theses on the topic 'Replication error'

Author: Grafiati

Published: 4 June 2021

Last updated: 8 February 2022

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1

Beyer, Tracey Elaine, and Tracey Elaine Beyer. "Ontogeny of Unstable Chromosomes Formed by Telomere Replication Error." Diss., The University of Arizona, 2016. http://hdl.handle.net/10150/621103.

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The integrity of the genome relies on the maintenance of chromosomes, the structural embodiment of the genetic material. Disruption of chromosome replication can lead to extensive genomic rearrangements, spanning kilobase (Kb) to megabase (Mb) regions. Some chromosome rearrangements are inherently dynamic, beginning as a single unstable rearrangement from which multiple rearrangements emerge. The rare formation and transient behavior of unstable chromosomes renders their study challenging. Here I characterize the genetic ontogeny of unstable chromosomes in a budding yeast model, from initial r

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2

Mamun, Mohammed Al. "Probabilistic modelling of replication fidelity in eukaryotic genomes." Thesis, University of Dundee, 2016. https://discovery.dundee.ac.uk/en/studentTheses/cd8bf41c-51cb-411d-816e-40783d8adc89.

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Eukaryotic DNA replication is composed of a complex array of molecular biological activities compounded by the pressure for faithful replication in order to maintain genetic and genomic integrity. The constraints governing DNA replication biology is of fundamental importance to understand the degree of replication error and strategies employed by organisms to tackle the threats to replication fidelity from such errors. We apply a simple conceptual model, formalized by the use of probability theory and statistics, to discern fundamental pressures and constraints that optimise complete DNA repli

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3

Jia, Weijia. "Goodness-of-fit tests in measurement error models with replications." Diss., Kansas State University, 2018. http://hdl.handle.net/2097/38660.

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Doctor of Philosophy<br>Department of Statistics<br>Weixing Song<br>In this dissertation, goodness-of-fit tests are proposed for checking the adequacy of parametric distributional forms of the regression error density functions and the error-prone predictor density function in measurement error models, when replications of the surrogates of the latent variables are available. In the first project, we propose goodness-of-fit tests on the density function of the regression error in the errors-in-variables model. Instead of assuming that the distribution of the measurement error is known as is

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4

Parker, Caitlin Grace. "Reframing the reproducibility crisis: using an error-statistical account to inform the interpretation of replication results in psychological research." Thesis, Virginia Tech, 2015. http://hdl.handle.net/10919/52963.

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Experimental psychology is said to be having a reproducibility crisis, marked by a low rate of successful replication. Researchers attempting to respond to the problem lack a framework for consistently interpreting the results of statistical tests, as well as standards for judging the outcomes of replication studies. In this paper I introduce an error-statistical framework for addressing these issues. I demonstrate how the severity requirement (and the associated severity construal of test results) can be used to avoid fallacious inferences that are complicit in the perpetuation of unreliable

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5

Yoshikawa, Munemitsu. "Comprehensive Replication of the Relationship Between Myopia-Related Genes and Refractive Errors in a Large Japanese Cohort." 京都大学 (Kyoto University), 2017. http://hdl.handle.net/2433/225503.

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6

Antonov, Andrii, and Tobias Schirra. "Tracking down European Markets : Tracking Performance of ETFs and Mutual Index Funds." Thesis, Umeå universitet, Företagsekonomi, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-76238.

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In recent years, the financial service industry demonstrated substantial growth of Exchange Traded Funds (ETFs). Apart from offering access to new and more specific investment opportunities, many ETFs enter direct competition with conventional, already existing Mutual Index Funds. With 22,1% growth of assets over the past 5 years, the European market by now accounts for 19% of the global ETF market, while at the same time we observe a decline of cash flows to Mutual Index Funds. Given the recent development, index investors are likely to face a choice between ETFs and Mutual Index Funds offeri

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7

Leonard, Robert D. "Considerations for Screening Designs and Follow-Up Experimentation." VCU Scholars Compass, 2015. http://scholarscompass.vcu.edu/etd/3928.

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The success of screening experiments hinges on the effect sparsity assumption, which states that only a few of the factorial effects of interest actually have an impact on the system being investigated. The development of a screening methodology to harness this assumption requires careful consideration of the strengths and weaknesses of a proposed experimental design in addition to the ability of an analysis procedure to properly detect the major influences on the response. However, for the most part, screening designs and their complementing analysis procedures have been proposed separately i

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8

Oliveira, Willian Luís de. "Inferência em um modelo com erros de medição heteroscedásticos com observações replicadas." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/55/55134/tde-15092011-085832/.

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Modelos com erros de medição têm recebido a atenção de vários pesquisadores das mais diversas áreas de conhecimento. O principal objetivo desta dissertação consiste no estudo de um modelo funcional com erros de medição heteroscedásticos na presença de réplicas das observações. O modelo proposto estende resultados encontrados na literatura na medida em que as réplicas são parte do modelo, ao contrário de serem utilizadas para estimação das variâncias, doravante tratadas como conhecidas. Alguns procedimentos de estimação tais como o método de máxima verossimilhança, o método dos momentos e o mét

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9

Meinhardt, Christian. "Essays on actively and passively managed financial products." Doctoral thesis, Humboldt-Universität zu Berlin, Wirtschaftswissenschaftliche Fakultät, 2015. http://dx.doi.org/10.18452/17310.

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Diese Dissertation besteht aus fünf empirischen Studien. Zwei Studien befassen sich mit passiv gemanagten Finanzprodukten. Sie untersuchen den Replikationsprozess von Exchange Traded Funds (ETFs) und vergleichen hierbei die Replikationsgüte von synthetischen und physischen ETFs. Oftmals wird darauf verwiesen, dass synthetische ETFs eine höhere Replikationsgüte besitzen als physische ETFs. Dies lässt sich für Renten-ETFs bestätigen, allerdings nicht für Aktien-ETFs. Zudem wird gezeigt, dass ETFs und Indexzertifikate, die sich im direkten Wettbewerb befinden, im Hinblick auf ihre Geldmittelflüss

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10

Kurt, Mehmet Can. "Fault-tolerant Programming Models and Computing Frameworks." The Ohio State University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=osu1437390499.

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11

Laos, Roberto. "Protein directed evolution." Revista de Química, 2012. http://repositorio.pucp.edu.pe/index/handle/123456789/99875.

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Evolución dirigida de proteínas: La evolución dirigida es una técnica que nos permite explorar funciones enzimáticas que no son requeridas en el ambiente natural. Esta técnica, simula procesos genéticos naturales y de selección. Esta estrategia se utiliza cuando un diseño racional es muy complicado. Consiste en una repetición de ciclos de diversificación y selección que llevan a la acumulación de mutaciones benéficas. Aquí se presenta dos ejemplos de evolución dirigida con los cuales se ha trabajado directamente: la ADN polimerasa del organismo Thermus aquaticus usada comúnmente en PCR, y la

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12

Ino, Naio. "Delta hedge com custos de transação: uma análise comparativa." reponame:Repositório Institucional do FGV, 2013. http://hdl.handle.net/10438/10480.

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Submitted by Naio Ino (naio.ino@gmail.com) on 2013-02-07T22:41:54Z No. of bitstreams: 1 Dissertao_Naio_Final.pdf: 809445 bytes, checksum: e28769fb7eb5f239534349c5e85a2cc9 (MD5)<br>Approved for entry into archive by Suzinei Teles Garcia Garcia (suzinei.garcia@fgv.br) on 2013-02-08T10:19:58Z (GMT) No. of bitstreams: 1 Dissertao_Naio_Final.pdf: 809445 bytes, checksum: e28769fb7eb5f239534349c5e85a2cc9 (MD5)<br>Made available in DSpace on 2013-02-08T12:09:39Z (GMT). No. of bitstreams: 1 Dissertao_Naio_Final.pdf: 809445 bytes, checksum: e28769fb7eb5f239534349c5e85a2cc9 (MD5) Previous issue da

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13

Heilbrun, Daniel Montero. "Estratégias de hedge dinâmico: um estudo comparativo." reponame:Repositório Institucional do FGV, 2017. http://hdl.handle.net/10438/18733.

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Submitted by Daniel Montero Heilbrun (daniel_heilbrun@hotmail.com) on 2017-08-31T18:50:44Z No. of bitstreams: 1 mestrado_dmh.pdf: 1853781 bytes, checksum: 1f83154ac6e3fdda760d5d9d053c4e72 (MD5)<br>Approved for entry into archive by Joana Martorini (joana.martorini@fgv.br) on 2017-08-31T18:54:10Z (GMT) No. of bitstreams: 1 mestrado_dmh.pdf: 1853781 bytes, checksum: 1f83154ac6e3fdda760d5d9d053c4e72 (MD5)<br>Made available in DSpace on 2017-09-01T12:18:19Z (GMT). No. of bitstreams: 1 mestrado_dmh.pdf: 1853781 bytes, checksum: 1f83154ac6e3fdda760d5d9d053c4e72 (MD5) Previous issue date: 2017

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14

Miller, Jean Anne. "Naturalism & Objectivity: Methods and Meta-methods." Diss., Virginia Tech, 2008. http://hdl.handle.net/10919/28329.

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The error statistical account provides a basic account of evidence and inference. Formally, the approach is a re-interpretation of standard frequentist (Fisherian, Neyman-Pearson) statistics. Informally, it gives an account of inductive inference based on arguing from error, an analog of frequentist statistics, which keeps the concept of error probabilities central to the evaluation of inferences and evidence. Error statistical work at present tends to remain distinct from other approaches of naturalism and social epistemology in philosophy of science and, more generally, Science and Technolog

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15

Rodriguez, Joan Neylo da Cruz. "Estimação em modelos funcionais com erro normais e repetições não balanceadas." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/45/45133/tde-19022013-171605/.

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Esta dissertação compreende um estudo da eficiência de estimadores dos parâmetros no modelo funcional com erro nas variáveis, com repetições para contornar o problema de falta de identificação. Nela, discute-se os procedimentos baseados nos métodos de máxima verossimilhança e escore corrigido. As estimativas obtidas pelos dois métodos levam a resultados similares.<br>This work is concerned with a study on the efficiency of parameter estimates in the functional linear relashionship with constant variances. Where the lack of identification is resolved of by considering replications. Estimation i

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16

Mazibas, Murat. "Dynamic portfolio construction and portfolio risk measurement." Thesis, University of Exeter, 2011. http://hdl.handle.net/10036/3297.

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The research presented in this thesis addresses different aspects of dynamic portfolio construction and portfolio risk measurement. It brings the research on dynamic portfolio optimization, replicating portfolio construction, dynamic portfolio risk measurement and volatility forecast together. The overall aim of this research is threefold. First, it is aimed to examine the portfolio construction and risk measurement performance of a broad set of volatility forecast and portfolio optimization model. Second, in an effort to improve their forecast accuracy and portfolio construction performance,

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17

Bentria, Dounia. "Combining checkpointing and other resilience mechanisms for exascale systems." Thesis, Lyon, École normale supérieure, 2014. http://www.theses.fr/2014ENSL0971/document.

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Dans cette thèse, nous nous sommes intéressés aux problèmes d'ordonnancement et d'optimisation dans des contextes probabilistes. Les contributions de cette thèse se déclinent en deux parties. La première partie est dédiée à l’optimisation de différents mécanismes de tolérance aux pannes pour les machines de très large échelle qui sont sujettes à une probabilité de pannes. La seconde partie est consacrée à l’optimisation du coût d’exécution des arbres d’opérateurs booléens sur des flux de données.Dans la première partie, nous nous sommes intéressés aux problèmes de résilience pour les machines

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18

Chou, Neng-An, and 周能安. "Proofreading of insertion/deletion error in slipped strand DNA replication." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/jasnar.

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碩士<br>國立臺灣大學<br>醫學檢驗暨生物技術學研究所<br>107<br>Insertion/deletion mutation is one of common point mutation during DNA replication . The occurrence of insertion/deletion mutation was thought due to repeated sequence being prone to slippage during DNA replication, so that the replicated product will gain or loss a few nucleotides.i.e. insertion/deletion errors. The insertion/deletion errors in replication can be corrected by the proofreading activity of the polymerase. Previous in vitro DNA synthesis study using template with simple repetitive sequences found that the proofreading efficiency of the pol

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19

Huang, Rui-Len, and 黃瑞蘭. "Germline and somatic mutation of hMSH2 gene conferring the replication error phenotype of two hereditary nonpolyposis colorectal cancer families." Thesis, 2000. http://ndltd.ncl.edu.tw/handle/14414760039200158164.

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碩士<br>國防醫學院<br>生物及解剖學研究所<br>88<br>Hereditary nonpolyposis colon cancer (HNPCC) is an autosomal inherited cancer syndrome characterized by germline and somatic mutations of DNA mismatch repair genes and subsequent accumulation of replication errors (RER, as indicated by microsatellite instability of MSI) and evolution of cancer clones. We report two Taiwanese HNPCC families with unusual phenotypes. Family J consists of five sisters contracting four endometrial carcinomas, one atypical hyperplasia of endometrium, and one soft tissue sarcoma at early (36~42) ages. Their father died of double canc

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20

Schürer, Anke. "Zur Funktion des MPH1-Gens von Saccharomyces cerevisiae bei der rekombinativen Umgehung von replikationsarretierenden DNA-Schäden." Doctoral thesis, 2004. http://hdl.handle.net/11858/00-1735-0000-0006-AE43-C.

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21

Ivana, Barbaric, W. Andrews Peter, J. A. Halliwell, et al. "Nucleosides Rescue Replication-Mediated Genome Instability of Human Pluripotent Stem Cells." 2020. http://hdl.handle.net/10454/18013.

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Yes<br>Human pluripotent stem cells (PSCs) are subject to the appearance of recurrent genetic variants on prolonged culture. We have now found that, compared with isogenic differentiated cells, PSCs exhibit evidence of considerably more DNA damage during the S phase of the cell cycle, apparently as a consequence of DNA replication stress marked by slower progression of DNA replication, activation of latent origins of replication, and collapse of replication forks. As in many cancers, which, like PSCs, exhibit a shortened G1 phase and DNA replication stress, the resulting DNA damage may underli

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