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Dissertations / Theses on the topic 'Replicative recombination'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Wagner, Tina [Verfasser]. "Telomere folding in S. cerevisiae depends on chromatin modifiers and recombination factors and is lost during replicative senescence / Tina Wagner." Mainz : Universitätsbibliothek der Johannes Gutenberg-Universität Mainz, 2020. http://d-nb.info/1224896106/34.

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2

Magdalou, Indiana. "Réponses post-réplicatives au stress réplicatif chronique faible ou endogène, chez les mammifères." Thesis, Paris 11, 2014. http://www.theses.fr/2014PA112389/document.

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La réplication de l’ADN est un phénomène physiologique essentiel à la transmission du patrimoine génétique mais est aussi une source importante de stress endogène. Le stress réplicatif peut conduire à une instabilité génomique et a été mis en évidence à une étape très précoce du développement tumoral et de la sénescence. La recombinaison homologue (RH) est un processus de réparation qui permet la prise en prise en charge du stress réplicatif. De ce fait, un défaut de RH devrait permettre de révéler les stress réplicatifs endogènes. Ainsi, une progression ralentie des fourches de réplication a

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3

Motamedi, Mohammad Reza. "RecBCD-mediated replication and recombination in Escherichia coli." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0013/NQ59638.pdf.

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4

Lundin, Cecilia. "Homologous recombination at replication forks in mammalian cells /." Stockholm : Institutionen för genetik, mikrobiologi och toxikologi, Univ, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-207.

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5

Kumari, Anuradha. "Recombination and DNA intermediates at stalled replication forks." Thesis, University of Sheffield, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.412791.

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6

White, Martin A. "Replication, recombination and chromosome segregation in Escherichia coli." Thesis, University of Edinburgh, 2010. http://hdl.handle.net/1842/4088.

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SbcCD has been shown to cleave a DNA hairpin formed by a palindromic DNA sequence on the lagging strand template of the E. coli chromosome. This activity was exploited to create a unique system for inducing a single site-specific DNA double-strand break (DSB) once per replication cycle. First, this work shows that the SOS response induced by this DSB is only essential for viability following multiple cycles of cleavage and repair. Next, the SOS-inducible inhibitor of cell division SfiA is shown to be dispensable for survival, despite demonstrating that cleavage of the palindrome causes both an

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7

Jordan, Christian. "Helicase-SSB Interactions In Recombination-Dependent DNA Repair and Replication." ScholarWorks @ UVM, 2014. http://scholarworks.uvm.edu/graddis/270.

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Dda, one of three helicases encoded by bacteriophage T4, has been well- characterized biochemically but its biological role remains unclear. It is thought to be involved in origin-dependent replication, recombination-dependent replication, anti- recombination, recombination repair, as well as in replication fork progression past template-bound nucleosomes and RNA polymerase. One of the proteins that most strongly interacts with Dda, Gp32, is the only single-stranded DNA binding protein (SSB) encoded by T4, is essential for DNA replication, recombination, and repair. Previous studies have shown

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8

McCreary, Ronald Patrick. "Recombination-dependent DNA replication in bacteriophage T4: An evolutionary study." Diss., The University of Arizona, 1990. http://hdl.handle.net/10150/185267.

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Genetic recombination is an ubiquitious process in living organisms and is one of the most elaborate activities that DNA undergoes. As such, the recombination process potentially interacts with all of the major metabolic events involving DNA. This study examined one of these interactions, specifically that occuring between recombination and DNA replication in phage T4. This interaction was investigated from both the mechanisitic and evolutionary viewpoints. In phage and bacteria, the central reactions of homologous recombination are those of homologous pairing and strand insertion. These react

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9

Weng, Ziming. "Replication and recombination of the Red clover necrotic mosaic virus." Diss., The University of Arizona, 2002. http://hdl.handle.net/10150/280079.

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In this study, Red clover necrotic mosaic virus (RCNMV) was used to better understand the functions of replication proteins and to identify the terminal promoter element involved in viral replication. RCNMV genome contains two positive-sense, single-stranded RNAs. RNA-1 encodes two proteins essential for viral replication: p27 and p88. p88 is a fusion protein containing p27 at its N terminus and RNA dependent RNA polymerase motifs at its C-terminal domain. The function of p27 is not known. In this work, studies of RNA-1 chimerical clones between a highly infectious clone and a poorly infectiou

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10

Tsang, Ellen. "Interplay between checkpoints and recombination at sites of replication fork arrest." Thesis, University of Sussex, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.488568.

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11

Pink, Catherine. "Gender specific impact of replication and recombination on rodent intron evolution." Thesis, University of Bath, 2012. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.557805.

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Mutation rate variability has been widely observed across mammalian genomes but the underlying causes are not yet fully understood. This thesis attempts to explain this variation, as assayed by the substitution rate of putatively neutral sites, across rodent genomes at three scales: genic, inter-autosomal and between chromosome types. It was shown that the method commonly employed to estimate the extent of male-bias in the mutation rate is flawed, suggesting that inter-chromosomal variation in mutation rates is not solely due to differences in the number of replications they undergo in each ge

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12

Jalan, Manisha. "Investigating the recombinational response to replication fork barriers in fission yeast." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:aed1673a-f967-41a5-9643-2e432052e174.

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Timely completion of DNA replication in each cell cycle is crucial for maintaining genomic integrity. This is often challenged by the presence of various replication fork barriers (RFBs). On collision with a RFB, the fate of the replication fork remains uncertain. In some cases, the integrity of the fork is maintained until the barrier is removed or the fork is rescued by merging with the incoming fork. However, fork stalling can cause dissociation of all of the associated replication proteins (fork collapse). If this occurs, the cell's recombination machinery can intervene to help restart rep

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13

Moisan, Alice. "Formes recombinantes inter-groupes M et O du VIH-1 : Etude de leur potentiel réplicatif et de leur émergence in vitro/in vivo In vivo emergence of an HIV-1/MO recombinant revealed undiagnosed HIV-1/M+O co-infection." Thesis, Normandie, 2019. http://www.theses.fr/2019NORMR126.

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Les VIH-1 sont caractérisés par une forte diversité génétique et la recombinaison génétique constitue un facteur important de leur évolution. Malgré leur grande divergence génétique, les VIH-1 groupe M, pandémique, et groupe O, endémique au Cameroun, peuvent générer des formes recombinantes intergroupes MO. La description actuellement de 19 formes recombinantes VIH-1/MO (URF_MO), dont 10 au cours de ces dix dernières années, pose la question d’un éventuel avantage conféré par la recombinaison et des modalités de leur émergence. Les objectifs de ce travail étaient donc d’étudier le potentiel ré

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14

Nguyen, Michael Ong. "Investigating the molecular mechanism of replication restart in fission yeast." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:b90fff59-d5b7-43b2-b648-61c0bc977ee9.

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Successful replication of the genome during each cell cycle requires that every replication fork merge with its opposing fork. However, lesions in the template DNA or protein-DNA barriers often impede replication forks and threaten the timely completion of genome duplication. If a fork encounters a replication fork barrier (RFB), it can be subject to a variety of fates. In some cases the replisome is maintained in a manner such that it can resume DNA synthesis when the barrier is removed. Alternatively the stalled fork is simply held in a competent state to merge with the opposing fork when it

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15

Mochizuki, Ayako. "PARI Regulates Stalled Replication Fork Processing To Maintain Genome Stability upon Replication Stress in Mice." Kyoto University, 2018. http://hdl.handle.net/2433/232303.

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16

Jones, Mady. "Mismatch repair in replication and in recombination in E. Coli: "Molecular Specificity"." Doctoral thesis, Universite Libre de Bruxelles, 1987. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/213432.

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17

Shapka, Natalia. "IDENTIFICATION OF VIRAL AND HOST FACTORS INVOLVED IN TOMBUSVIRUS REPLICATION AND RECOMBINATION." UKnowledge, 2006. http://uknowledge.uky.edu/gradschool_diss/449.

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Rapid evolution of RNA viruses with mRNA-sense genomes is a major concern to health and economic welfare due to the devastating diseases these viruses inflict on humans, animals and plants. Rapid viral RNA evolution is frequently due to RNA recombination, which can be facilitated by recombination signals present in viral RNAs. Among such signals are short sequences with high AU contents that constitute recombination hot spots in Brome mosaic virus (BMV) and retroviruses. We have demonstrated that a defective interfering (DI) RNA, a model template associated with Tomato bushy stunt virus (TBSV)

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18

Stirrups, Kathleen Elizabeth. "A defective-RNA expression vector for targeted recombination of the coronavirus infectious bronchitis virus." Thesis, University of Reading, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.285965.

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19

Anderson, Jeffrey A. "Retroviral recombination during reverse transcription an analysis of the mechanism, frequency, and effect of the viral packaging signal [psi] /." Morgantown, W. Va. : [West Virginia University Libraries], 2001. http://etd.wvu.edu/templates/showETD.cfm?recnum=1822.

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Thesis (Ph. D.)--West Virginia University, 2001.<br>Title from document title page. Document formatted into pages; contains viii, 174 p. : ill. Vita. Includes abstract. Includes bibliographical references.

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Panaviene, Zivile Sliesaraviciute. "THE ROLE OF TOMBUSVIRUS REPLICASE PROTEINS AND RNA IN REPLICASE ASSEMBLY, REPLICATION AND RECOMBINATION." UKnowledge, 2004. http://uknowledge.uky.edu/gradschool_diss/435.

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Tombusviruses are single, positive strand RNA viruses of plants, often associated with parasitic defective interfering (DI) RNAs. Two viral- coded gene products, namely p33 and p92, are required for tombusvirus replication. The overlapping domains of p33 and p92 contain an arginine/proline-rich (RPR) RNA binding motif. In this study, the role of RPR motif and viral RNA in tombusvirus replication and recombination, as well as involvement of viral RNA in tombusvirus replicase assembly was examined. Using site-directed mutagenesis I generated a series of RPR mutants of Cucumber necrosis tombusvir

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21

Wilhelm, Therese. "Homologous recombination protects against mitotic defects and unbalanced chromosome segregation caused by spontaneous replication stress." Thesis, Paris 11, 2011. http://www.theses.fr/2011PA112059.

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Les cellules déficientes pour la recombinaison homologue (RH) présentent un ralentissement des fourches de réplication, un nombre aberrant de centrosomes et une aneuploïdie même en absence de stress exogène (Bertrand P 2003, Daboussi F 2005, 2008, Deng 1999, 2002, Griffin 2000, Kraakman-van der Zwet 2002). De plus, la fréquence des mitoses présentant des chromosomes surnuméraires est plus élevée dans ces cellules.L’ensemble des ces résultats suggéraient que le ralentissement des fourches de réplication dans les cellules déficientes pour la RH pourrait avoir un impact direct sur la formation de

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22

Liu, Jiong. "Assembly of the (Phi)x-type primosome : on a primosome assembly site and a recombination intermediate /." Access full-text from WCMC, 1998. http://proquest.umi.com/pqdweb?did=733079761&sid=1&Fmt=2&clientId=8424&RQT=309&VName=PQD.

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23

Edwards, Deanna. "RELATIONSHIPS BETWEEN TELOMERIC SEQUENCES AND STRUCTURES, DNA REPLICATION, AND THE FUNCTION OF THE WERNER SYNDROME PROTEIN." UKnowledge, 2012. http://uknowledge.uky.edu/toxicology_etds/3.

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All human chromosomes end with protective structures called telomeres, which consist of thousands of double-stranded TTAGGG repeats and end in a 3’ guanine-rich overhang. These structures shorten normally during each round of replication, and extremely short telomeres along with telomere dysfunction are thought to contribute to the development of aging and cancer. Although many proteins have roles in telomere maintenance, WRN, which is a 3’ to 5’ helicase that is deficient in the premature aging disorder Werner’s syndrome, has been proposed to play multiple roles at telomeres. In this study, I

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24

Ward, Jordan David. "Insight into homologous recombination at replication blocking lesions through analysis of the C. elegans RAD-51 paralog, RFS-1." Thesis, University College London (University of London), 2008. http://discovery.ucl.ac.uk/1446191/.

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The ability to sense and repair replication blocking DNA damage is a critical task for a cell, as evidenced by the embryonic lethality or cancer predisposition caused by mutation in any of these processes. Recent work has implicated homologous recombinational repair (HRR) as a key player in promoting genome stability in response to stalled replication forks, in addition to its well documented role of in the error-free repair of DNA double-strand breaks (DSBs). Although the five paralogs of the mammalian recombinase, Rad51, have been suggested to be general mediators of HRR, genetic evidence fa

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25

FALCETTONI, MARCO CESARE. "Role and regulation of homologous recombination in response to DNA double strand breaks and replication stress in Saccharomyces cerevisiae." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2014. http://hdl.handle.net/10281/50242.

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Homologous recombination (HR) is a key pathway to maintain genomic integrity from one generation to another (meiosis) and during ontogenic development in a single organism (DNA repair). Recombination is required for the repair or tolerance of DNA damage and the recovery of stalled or broken replication forks. However, recombination is also potentially dangerous as it can lead to gross chromosomal rearrangements and potentially lethal intermediates. For this reason, recombinational events must be strictly regulated depending on the organism, cell type, cell-cycle stage, chromosomal region, as w

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26

Haghnazari, Edwin. "Regulation of homologous recombinational DNA repair by DNA damage and replication block checkpoints in Saccharomyces cerevisiae /." For electronic version search Digital dissertations database. Restricted to UC campuses. Access is free to UC campus dissertations, 2004. http://uclibs.org/PID/11984.

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27

Silva, Ana Carolina. "Ku coordonne la résection des fourches de réplication bloquées, et stimule le redémarrage des fourches par la recombinaison homologue." Thesis, Université Paris-Saclay (ComUE), 2017. http://www.theses.fr/2017SACLS135.

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Au cours de la réplication de l’ADN, les cellules rencontrent régulièrement des obstacles d’origine endogène et exogène qui peuvent mettre en péril la réplication des génomes et menacer la duplication et ségrégation des chromosomes en mitose. La Recombinaison Homologue (RH) a un rôle bien caractérisé dans la réparation des cassures double-brin. Par contre, son rôle dans la protection et le redémarrage des fourches de réplication est moins bien caractérisé. Il a été montré par l’équipe que le redémarrage des fourches bloquées par la RH dépend de la formation d’ADN simple-brin et pas d’une cassu

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Zhang, Yu. "Mechanisms of chromosomal instability induced by unstable DNA repeats in yeast S.cerevisiae." Diss., Georgia Institute of Technology, 2013. http://hdl.handle.net/1853/52185.

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DNA repetitive sequences capable of adopting non-B DNA structures are a potent source of instability in eukaryotic genomes. They are strong inducers of chromosomal fragility and genome rearrangements that cause various hereditary diseases and cancers. In addition, a subset of repeats also has an ability to expand, which leads to more than 20 human genetic diseases that are collectively known as repeat expansion diseases. However, the mechanisms underlying the potential of these structure-prone motifs to break and expand are largely unknown. In this study, a systematic genome-wide screen w

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Kohzaki, Masaoki. "Cooperative roles of vertebrate Fbh1 and Blm DNA helicases in avoidance of crossovers during recombination initiated by replication fork collapse." Kyoto University, 2007. http://hdl.handle.net/2433/135695.

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30

Hardy, Julien. "Rôles de l'endonucléase Sae2 et de l'helicase Sgs 1 dans le métabolisme des télomères chez la levure Saccharomyces cerevisiae." Thesis, Aix-Marseille, 2012. http://www.theses.fr/2012AIXM4063/document.

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Les télomères sont des structures nucléo-protéiques présentes à l'extrémité des chromosomes. Ils sont un des facteurs garant de la stabilité génomique. Ils assurent la protection des extrémités des chromosomes et leur entière réplication. Les dysfonctionnements du télomère sont impliqués dans la tumorigénèse et le vieillissement.Un des rôles majeurs des télomères est d'éviter que les extrémités des chromosomes ne soient reconnues comme des cassures double brin de l'ADN et traitées comme telles par la machinerie de réparation. Cependant, de nombreuses protéines impliquées dans la reconnaissance

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Fumasoni, M. "REPLICATION-ASSOCIATED REPRIMING AND PRIMER PROCESSING FACILITATE ERROR-FREE DNA DAMAGE TOLERANCE AND SISTER CHROMATID SYNAPSIS." Doctoral thesis, Università degli Studi di Milano, 2014. http://hdl.handle.net/2434/234145.

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DNA damage tolerance (DDT) mechanisms are crucial for genome integrity as they allow efficient bypass of endogenously or exogenously generated lesions. Error-free bypass of lesions is accomplished by a recombination-related mechanism, generally referred to as template switching (TS), that allows the recovery of the damaged information from the sister chromatid. Pioneer studies revealed key enzymatic functions required for error-free DDT and identified sister chromatid junctions (SCJs) as crucial DNA intermediates mediating this process. However, little is known on the temporal window and the c

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Serrano, Moises A. "Novel Roles of Replication Protein A Phosphorylation in Cellular Response to DNA Damage." Digital Commons @ East Tennessee State University, 2013. https://dc.etsu.edu/etd/1206.

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Human replication protein A (RPA) is an eukaryotic single-stranded DNA binding protein directly involved in a variety of DNA metabolic pathways including replication, recombination, DNA damage checkpoints and signaling, as well as all DNA repair pathways. This project presents 2 novel roles of RPA in the cellular response to DNA damage. The first elucidates the regulation of RPA and p53 interaction by DNA-dependent protein kinase (DNA-PK), ataxia telangiectasia mutated (ATM) and ATM- and Rad3-related (ATR) in homologous recombination (HR). HR and nonhomologous end joining (NHEJ) are 2 distinct

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Olivier, Margaux. "Rôle des protéines de la recombinaison dans le maintien des télomères." Thesis, Université Clermont Auvergne‎ (2017-2020), 2017. http://www.theses.fr/2017CLFAC038/document.

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Les télomères sont des structures nucléoprotéiques spécialisées qui assurent l’intégrité des extrémités des chromosomes linéaires. Ils sont composés d’une séquence d’ADN qui leur est propre, sont associées à des protéines spécifiques, et sont maintenus par la télomérase. Leur fonction est d’empêcher le raccourcissement progressif des extrémités des chromosomes dû à la réplication ainsi que leur reconnaissance par les mécanismes de réparation des cassures double brin. La réparation des cassures double-brin consiste en deux mécanismes généraux : la recombinaison non-homologue et la recombinaison

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Saint-Léger, Adélaïde. "Rôle de la protéine TRF2 et de ses partenaires dans la recombinaison des télomères humains." Thesis, Lyon, École normale supérieure, 2011. http://www.theses.fr/2011ENSL0695.

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La protéine télomérique TRF2 permet de protéger les télomères notamment en régulant leur taille. Dans des cellules humaines, la surexpression de la protéine mutante TRF2ΔB, dont le domaine basique est absent, induit un raccourcissement soudain des télomères. In vitro, ce domaine basique protège des structures d’ADN particulières, appelées Jonctions de Holliday (JH), de la résolution par des endonucléases. Ces JH peuvent être présentes aux télomères d’une part au niveau de la boucle télomérique, une conformation de l’ADN qui ressemble à une structure intermédiaire de la recombinaison homologue

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Linger, Jeffrey G. "The role of histone chaperones in double-strand DNA repair and replication-independent histone exchange /." Connect to full text via ProQuest. IP filtered, 2006.

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Thesis (Ph.D. in Biochemistry) -- University of Colorado, 2006.<br>Typescript. Includes bibliographical references (leaves 153-171). Free to UCDHSC affiliates. Online version available via ProQuest Digital Dissertations;

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Pang, Zhenhua. "Surveying the chromosomal supercoiling levels in rapidly growing wild type and gyrase mutant strains of Salmonella enterica serovar Typhimurium with [gamma delta] resolvase-mediated recombination assay." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2007. https://www.mhsl.uab.edu/dt/2007r/pang.pdf.

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Thomas, Mélissa. "Origins of Cellular Lethality Resulting From a Defect in Homologous Recombination in Human Cells." Thesis, université Paris-Saclay, 2021. http://www.theses.fr/2021UPASL027.

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La recombinaison homologue (RH) est impliquée dans la réparation des cassures double brin à l'ADN, et dans la gestion des fourches de réplication bloquées. Rad51 et BRCA2 en sont deux protéines pivots.J'ai montré que l'inhibition de la RH ainsi que la surexpression de Rad51 sont létales dans les cellules humaines, mais qu'un faible nombre de cellules arrivent à survivre. De plus, dans plusieurs cancers, les gènes de la RH sont mutés (BRCA1/2 dans les cancers du sein et de l'ovaire) ou la surexpression d'un gène de la RH est observée. Mon projet a pour but d'identifier les mécanismes et les cau

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Ait, Saada Anissia. "Mécanismes par lesquels la recombinaison homologue prévient les défauts mitotiques induits par le stress réplicatif." Thesis, Université Paris-Saclay (ComUE), 2018. http://www.theses.fr/2018SACLS167/document.

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Des stress réplicatifs sont rencontrés à chaque phase S du cycle cellulaire et différents mécanismes permettent leur prise en charge. La recombinaison homologue (RH) tient un rôle important dans le maintien de la stabilité du génome au cours de la réplication. En effet, la RH escorte la progression des fourches et prévient les défauts mitotiques. Toutefois, le lien moléculaire entre le stress réplicatif et les défauts mitotiques n’est pas élucidé. De façon générale, les fourches de réplication bloquées peuvent être sauvées grâce à leur fusion avec la fourche convergente ou au redémarrage de fo

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Bellini, Angela. "Rôle des voies de réponse au stress dans le maintien de la stabilité génomique chez la levure Schizosaccharomyces pombe." Thesis, Paris 11, 2012. http://www.theses.fr/2012PA11T048/document.

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Le génome est sans cesse menacé dans sa structure par des stress génotoxiques d’origine endogène (stress oxydant, blocage de la réplication…) ou exogène (irradiations, produits chimiques, métaux lourds…). La voie de réponse aux dommages de l’ADN coordonne un réseau d’événements en cascades qui incluent les points de surveillance du cycle cellulaire, la réplication/réparation/recombinaison de l’ADN et la mort cellulaire programmée. Ces voies collaborent pour assurer la transmission fidèle du génome et empêcher la prolifération des cellules qui aurait accumulé des altérations génétiques. En géné

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Lee, Sungkeun. "Molecular genetic analysis of nucleotide excision repair genes in Dictyostelium discoideum /." free to MU campus, to others for purchase, 1997. http://wwwlib.umi.com/cr/mo/fullcit?p9841209.

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Pluchon, Pierre-François. "Exploration du réseau d’interactions impliqué dans la maintenance génomique de l'Archaea hyperthermophile Pyrococcus abyssi." Thesis, Brest, 2012. http://www.theses.fr/2012BRES0070/document.

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Les organismes vivants doivent reproduire et transmettre ne variatur l’information contenue dans les chromosomes. Ainsi, la conservation de l’intégrité du génome est un processus biologique fondamental. La maintenance génomique constitue l’ensemble des processus biologiques impliqués dans la conservation, la duplication et la transmission de l’information génétique contenue dans les chromosomes. La machinerie réplicative des Archaea est décrite comme une version simplifiés de celle connue chez les Eucaryotes faisant des Archaea un excellent modèle d’étude de la réplication. Contrairement à la

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Vasianovich, Yuliya. "Investigating the roles of the Srs2 and Pif1 helicases in DNA double-strand break repair in Saccharomyces cerevisiae." Thesis, University of Edinburgh, 2015. http://hdl.handle.net/1842/17984.

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DNA double strand breaks (DSBs), which may occur during DNA replication or due to the action of genotoxic agents, are extremely dangerous DNA lesions as they can cause chromosomal rearrangements and cell death. Therefore, accurate DSB repair is vital for genome stability and cell survival. Two main mechanisms serve to repair DNA DSBs: non-homologous end joining, which re-ligates DNA ends together, and homologous recombination (HR), which restores broken DNA using homologous sequence as a template for repair. One-ended DSBs are a subject for the specialised HR-dependent repair pathway known as

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Yu, Sung-Lim. "Analysis of the response of nucleotide excision repair genes in Dictyostelium discoideum /." free to MU campus, to others for purchase, 1997. http://wwwlib.umi.com/cr/mo/fullcit?p9841196.

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Bain, Amanda Louise. "Investigation of the Physiological Role of Ssb1 using an in-vivo Targeted Mouse Model." Thesis, Griffith University, 2013. http://hdl.handle.net/10072/366937.

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Single-stranded DNA binding proteins (SSBs) are critical for binding, protecting and sequestering single-stranded DNA intermediates during multiple cellular transactions, including DNA replication, repair and transcription. The canonical SSB in eukaryotes, Replication Protein A (RPA), is a heterotrimeric protein essential for numerous cellular processes, including DNA repair by homologous recombination (HR). Recently, Richard et al. (2008) identified a novel human SSB, designated human Single-Stranded DNA Binding protein 1 (hSSB1), critical to DNA repair and the maintenance of genomic stabilit

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Schneider, Dominique. "Plasticité génomique chez streptomyces ambofaciens dsm40697 : analyses structurale et transcriptionnelle d'un point chaud de délétion." Nancy 1, 1993. http://www.theses.fr/1993NAN10244.

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L'étude a porté sur le locus amplifiable et délectable aud6 de l'eubactérie streptomyces ambofaciens. Ce locus est conservé dans les différentes souches sauvages. L'analyse d'une partie de ce locus a révélé la présence de deux gènes transcrits, appelés spar et spa2. Leur région régulatrice présente des promoteurs divergents. Le gène spar est surtranscrit à l'état amplifié, contrairement au gène spa2 qui est alors réprimé. Ces résultats infirment l'hypothèse selon laquelle la région instable est vide de gènes. Une forte fréquence d'amplifications et d'extrémités de délétion est observée à l'int

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Cordova, Caio Mauricio Mendes de. "Desenvolvimento de plasmídeos replicativos artificiais para transformação de Mycoplasma pulmonis, M. capricolum e M. mycoïdes subsp. mycoïdes, e dirupção do gene da hemolisina A de M. pulmonis por recombinação homóloga." Universidade de São Paulo, 2002. http://www.teses.usp.br/teses/disponiveis/9/9136/tde-20082008-112933/.

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Os micoplasmas são os menores microrganismos capazes de autoreplicação conhecidos na natureza, responsáveis por uma série de doenças no homem e nos animais, infectando ainda plantas e insetos. Constituem um grande grupo de bactérias, ordenadas em diferentes gêneros na classe Mollicutes, cuja principal característica em comum, além do genoma reduzido, é a ausência de parede celular. Mycoplasma mycoïdes subsp. mycoïdes SC, responsável pela Pleuropneumonia Contagiosa Bovina, foi o primeiro microrganismo desta classe de bactérias a ser identificado. Esta é uma doença bastante grave, com altas taxa

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Chakraborty, Shrena. "Multifaceted role of SUMOylation in maintaining centromere biology and regulation of replication fork restart in Schizosaccharomyces pombe." Electronic Thesis or Diss., université Paris-Saclay, 2024. http://www.theses.fr/2024UPASL069.

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Les défauts dans le processus de réplication de l'ADN, connus sous le nom de stress de réplication, sont une source majeure d'instabilité du génome qui favorise le développement du cancer. La résolution du stress de réplication se produit dans un noyau compartimenté qui présente des capacités distinctes de réparation de l'ADN. Les fourches de réplication stressées présentent une mobilité accrue et se déplacent vers la périphérie du noyau pour s'ancrer aux complexes du pore nucléaire, une structure hautement conservée de l'enveloppe nucléaire qui agit comme un site d'amarrage pour permettre à d

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Hogrel, Gaëlle. "Interactions entre composants de la maintenance génomique chez Archaea hyperthermophiles : étude des associations entre PCNA et le complexe Mre11-Rad50 et entre les hélicases MCM et XPD." Thesis, Brest, 2015. http://www.theses.fr/2015BRES0082/document.

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Vivant à des températures supérieures à 80°C, les archées hyperthermophiles ont démontré une capacité étonnante à se remettre de dommages dans leur ADN, suggérant la présence de gardiens du génome particulièrement efficaces. Ces gardiens, des protéines relativement similaires entre archées et eucaryotes, agissent et interagissent dans un ballet savamment orchestré par la cellule. Chez les archées, plusieurs protéines impliquées dans des voies essentielles à la réparation de I'ADN manquent à I'appel. Précédemment au laboratoire un réseau impliquant les protéines de la maintenance génomique de P

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Lu, Yang. "Functional studies of new protein-protein interactions potentially involved in homologous recombination in hyperthermophilic archaea : study of interactions between PCNA and Mre11-Rad50 complex & Primase and RadA." Thesis, Brest, 2018. http://www.theses.fr/2018BRES0077/document.

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Les archées hyperthermophiles ont une température optimale de croissance supérieure à 80°C.Les cellules exposées à un stress thermique subissent une augmentation de la sensibilité aux agents induisant des cassures double brin de l’ADN. Les études sur les eucaryotes et bactéries ont démontré que la recombinaison homologue joue un rôle essentiel non seulement dans la réparation de l’ADN, mais aussi dans le redémarrage des arrêts de la fourche de réplication. Les enzymes associées aux étapes initiales de la recombinaison homologue chez les archées sont homologues à celles des eucaryotes, et diffé

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Otsuki, Hiroyuki. "Generation of a replication-competent simian-human immunodeficiency virus, the neutralization sensitivity of which can be enhanced in the presence of a small-molecule CD4 mimic." Kyoto University, 2014. http://hdl.handle.net/2433/188701.

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