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Dissertations / Theses on the topic 'Reporter mouse'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Tyas, David Anthony. "Generation of a Pax6 reporter mouse." Thesis, University of Edinburgh, 2004. http://hdl.handle.net/1842/27562.

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In order to better understand Pax6 function I generated a novel tool – a ‘<i>Pax6</i> reporter’ transgenic mouse that expresses GFP under the control of <i>Pax6</i> regulatory elements. The transgenic mouse was generated from a modified yeast artificial chromosome (YAC) that contains the human <i>PAX6</i> gene and has been previously demonstrated to rescue loss of endogenous <i>Pax6</i> in <i>Pax6<sup>sey/sey</sup></i><sub> </sub>mice. The key advantages of a YAC addition transgenic include that it is already known that <i>Pax6</i> regulatory elements are present over a 200Kb region and insert

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2

Jones, Meaghan Jessica. "Characterization of a novel fluorescent reporter of genomic imprinting in the mouse." Thesis, University of British Columbia, 2010. http://hdl.handle.net/2429/23320.

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Regulation of inserted transcriptional units by epigenetic means has been reported for many years, and has been used to study characteristics of epigenetic regulation. Some of these transgenes have become regulated by genomic imprinting, and thus are expressed from only one of the two parental chromosomes and, occasionally, acquire parent-of-origin-specific epigenetic markings such as DNA methylation. These transgenes in particular have been useful in elucidating mechanisms of imprinted regulation. Here is described the first imprinted fluorescent transgene, a green fluorescent protein (GFP)

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3

Rode, Christina. "Cell type-specific Runx1 enhancer-reporter mouse lines to study hemogenic endothelium." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:49b91ea8-36a3-4bcd-8842-baa1ee31c7b9.

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Hematopoietic stem cells emerge from a specialized subset of endothelial cells in the midgestation mouse aorta. This subset, the so-called hemogenic endothelium (HE), undergoes a morphological and molecular change to a hematopoietic cell type, as part of the endothelial-to- hematopoietic transition (EHT). Previously, lack of specific markers prevented mechanistic studies of HE, as well as studies into its developmental origin. Runx1 is a critical regulator of developmental hematopoiesis and is expressed in all cell intermediates of EHT. Identification of the Runx1 +23 enhancer led to the devel

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4

Hung, Siu-chun. "Analysis of abnormal branchial arch structures of a Hoxb3 transgenic mouse mutant using a lacZ Reporter mouse line." Click to view the E-thesis via HKUTO, 2004. http://sunzi.lib.hku.hk/hkuto/record/B31971830.

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5

Hung, Siu-chun, and 洪少俊. "Analysis of abnormal branchial arch structures of a Hoxb3 transgenic mouse mutant using a lacZ Reporter mouse line." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B31971830.

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6

Bellosi, Agustín. "Investigation of interleukin-13 immune responses in vivo using novel reporter mouse strains." Thesis, University of Cambridge, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.608822.

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7

Yadollahi, Faranak. "The clusterin gene in mouse inner ear development : expression analysis and generation of reporter constructs." Thesis, University of Sussex, 2013. http://sro.sussex.ac.uk/id/eprint/45293/.

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Clusterin has previously been identified as a gene potentially involved in development of the cochlear sensory epithelium. In order to be able to predict the cellular roles that clusterin may play in the development of this organ, an understanding of the spatiotemporal expression pattern is required. Therefore, clusterin gene expression during mouse inner ear development was studied using riboprobes from the mouse gene. Clusterin mRNA demonstrates a dynamic expression pattern within the developing cochlear sensory epithelium. Clusterin mRNA expression is initiated at 12.5dpc (days post coitum)

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8

Petkova, Mina. "Generation and characterization of a dmdegfp reporter mouse as a tool to investigate dystrophin expression." Thesis, Paris 6, 2016. http://www.theses.fr/2016PA066090/document.

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La dystrophine est une protéine cytoplasmique qui lie physiquement le cytosquelette à la matrice extracellulaire par le biais du complexe dystrophine-protéines associées (DAPC), assurant ainsi la stabilité du sarcolemme. Des mutations dans le gène DMD codant pour la dystrophine, conduisant à l’absence de la protéine, sont à l’origine de la dystrophie musculaire de Duchenne qui est une maladie liée au chromosome X. Pour mes travaux de thèse, j’ai généré et caractérisé un nouveau modèle de souris transgéniques rapportrices, dénommé DmdEGFP, qui exprime une protéine dystrophine endogène fusionnée

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9

Petkova, Mina. "Generation and characterization of a dmdegfp reporter mouse as a tool to investigate dystrophin expression." Electronic Thesis or Diss., Paris 6, 2016. https://accesdistant.sorbonne-universite.fr/login?url=https://theses-intra.sorbonne-universite.fr/2016PA066090.pdf.

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La dystrophine est une protéine cytoplasmique qui lie physiquement le cytosquelette à la matrice extracellulaire par le biais du complexe dystrophine-protéines associées (DAPC), assurant ainsi la stabilité du sarcolemme. Des mutations dans le gène DMD codant pour la dystrophine, conduisant à l’absence de la protéine, sont à l’origine de la dystrophie musculaire de Duchenne qui est une maladie liée au chromosome X. Pour mes travaux de thèse, j’ai généré et caractérisé un nouveau modèle de souris transgéniques rapportrices, dénommé DmdEGFP, qui exprime une protéine dystrophine endogène fusionnée

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10

Petkova, Mina [Verfasser]. "Generation and Characterization of a DmdEGFP Reporter Mouse as a Tool to Investigate Dystrophin Expression / Mina Petkova." Berlin : Freie Universität Berlin, 2016. http://d-nb.info/1114735175/34.

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11

Carr, Catherine. "Microarray investigation of the role of Pax6 at the PSPB using a novel tauGFP-Pax6 reporter mouse." Thesis, University of Edinburgh, 2009. http://hdl.handle.net/1842/4148.

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Pax6 encodes a highly conserved transcriptional regulator that is widely expressed during development of the eye, olfactory bulbs and central nervous system. Pax6-/- mice exhibit severe brain defects, lack eyes and nasal structures, and die at birth. Included among the functions of Pax6 are cell adhesion, cell cycle progression, axon guidance and boundary formation. The pallial-subpallial boundary (PSPB) is both a physical and gene expression boundary separating dorsal and ventral telencephalon. Pax6 is required for this boundary to develop. In Pax6-/- embryos, genes which normally have a shar

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12

Klein, Annabelle. "Characterization of developmental senescence using a new reporter mouse model to identify genes common across senescence states." Electronic Thesis or Diss., Strasbourg, 2024. http://www.theses.fr/2024STRAJ032.

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La sénescence cellulaire est un état cellulaire caractérisé par un arrêt stable du cycle cellulaire, de nombreux changements intracellulaires et un phénotype de sécrétion. Ce processus peut être néfaste dans de nombreux contextes, mais il peut aussi être bénéfique, comme au cours du développement embryonnaire. A ce jour, il n'existe pas de marqueurs spécifiques de la sénescence cellulaire. Dans ce projet de thèse, j'ai validé un nouveau modèle murin de sénescence, la souris p21-mCherry-CreERT2, in vitro et in vivo. J'ai ensuite utilisé cette souris pour définir le transcriptome de la sénescenc

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13

Pratt, Thomas. "An investigation into the genetic control of thalamocortical tract projection in the mouse using a fluorescent reporter transgene." Thesis, University of Edinburgh, 2001. http://hdl.handle.net/1842/23157.

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Studies of mutant mice whose thalamocortical tract is disrupted illustrate that genes involved in programming thalamocortical tract navigation are required by projecting cells of the dorsal thalamus and along its route to supply axon navigation cues. Small-eye homozygotes (<i>Pax6<sup>Sey/Sey</sup></i>) in which the transcription factor Pax6 is inactivated exhibit a range of defects throughout the developing central nervous system, including a failure in thalamocortical tract formation, and die at birth. The <i>Pax6<sup>sey/Sey</sup></i> phenotype describes disruption of both the dorsal thalam

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14

Fredén, Linnéa. "Characterization of the fusion protein mNG-Aβ1-42 as a fluorescence reporter probe for amyloid structure". Thesis, Linköpings universitet, Institutionen för fysik, kemi och biologi, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-167167.

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Alzheimer’s Disease, also called AD, is a horrible, degenerative brain disease that more than 35 million people over the world have. Today, there is no cure for this disease, only treatments that are temporarily relieving the symptoms. The two proteins that is thought to be the main cause of AD is amyloid β (Aβ) and tau. Previously, people have tried studying Aβ in vivo using green fluorescent protein fusion together with Aβ. However, this is difficult since the aggregation of Aβ will lead to loss of fluorescence. This study aimed to crystallize the fusion protein mNG-A β1-42 and to investigat

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15

Dußmann, Philipp [Verfasser], and Elisabeth [Akademischer Betreuer] Deindl. "Characterization of a transgenic mouse expressing the reporter gene luciferase under the control of the murine early growth response-1 promoter / Philipp Dußmann. Betreuer: Elisabeth Deindl." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2016. http://d-nb.info/1096162571/34.

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16

Isensee, Jörg. "Deciphering the function of G protein-coupled receptor 30." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2009. http://dx.doi.org/10.18452/15964.

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Der G Protein-gekoppelte Rezeptor 30 (GPR30) wurde vornehmlich im Kontext von schnellen Östrogeneffekten auf zelluläre Signaltransduktionskaskaden untersucht und stellt möglicherweise einen neuen Östrogenrezeptor dar. Die physiologische Funktion von GPR30 in vivo konnte jedoch bisher nicht ermittelt werden. Daher wurde in dieser Arbeit ein Gpr30-defizientes Mausmodell charakterisiert, bei dem ein Teil der kodierenden Sequenz durch einen LacZ-Reporter ersetzt wurde (Gpr30-lacZ). Die Integration des Konstruktes in den Gpr30-Locus wurde mittels Southern blotting und Real-time PCR verifiziert. G

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17

Arbeiter, Andreas [Verfasser], Bernhard [Akademischer Betreuer] Küster, and Dieter K. M. [Akademischer Betreuer] Saur. "Generation of a spatiotemporally inducible reporter mouse model for in vivo imaging of pancreatic cancer therapy / Andreas Arbeiter. Gutachter: Bernhard Küster ; Dieter K. M. Saur. Betreuer: Bernhard Küster." München : Universitätsbibliothek der TU München, 2014. http://d-nb.info/1061126021/34.

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18

Mastropaolo, Matthew David. "Studies of Three Human Intestinal Opportunistic Pathogens." Diss., Virginia Tech, 2008. http://hdl.handle.net/10919/28529.

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Opportunistic bacterial pathogens are present in the intestines of all mammals. These bacteria are symbionts to a certain extent, but under certain conditions these organisms can be deadly. Intestinal opportunistic pathogens encompass many genera and include organisms such as those in the Bacteroides fragilis group (i.e. B. fragilis and B. thetaiotaomicron), Escherichia coli, and Clostridium perfringens, resulting in an array of diseases and serious health risks. Typically these diseases affect individuals in poor or weakened health (elderly, immuno-compromised, neonates, etc.) but can affe

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19

Wang, Hui [Verfasser], Martin [Akademischer Betreuer] Klingenspor, Thomas [Gutachter] Skurk, and Martin [Gutachter] Klingenspor. "Phenotypic characterization of a novel Ucp1-LUC-iRFP713 reporter mouse model for visualization and quantification of brown and beige fat recruitment / Hui Wang ; Gutachter: Thomas Skurk, Martin Klingenspor ; Betreuer: Martin Klingenspor." München : Universitätsbibliothek der TU München, 2019. http://d-nb.info/1211725154/34.

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20

PILLAI, Vinoshene. "Intravital two photon clcium imaging of glioblastoma mouse models." Doctoral thesis, Scuola Normale Superiore, 2021. http://hdl.handle.net/11384/109211.

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21

Strawbridge, Stanley Eugene. "Understanding the dynamics of embryonic stem cell differentiation." Thesis, University of Cambridge, 2019. https://www.repository.cam.ac.uk/handle/1810/287576.

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The two defining features of mouse embryonic stem (ES) cells are self-renewal and naive pluripotency, the ability to give rise to all cell lineages in the adult body. In addition to being a unique and interesting cell type, pluripotent ES cells have demonstrated their potential for continued advancements in biomedical science. Currently, there is an improved understanding in the chemical signals and the gene regulatory network responsible for the maintenance of ES cells in the naive pluripotent state. However, less is understood about how ES cells exit pluripotency. My main aim is to study the

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22

Joseph, Julie [Verfasser], and Stephan [Akademischer Betreuer] Kissler. "Studying the role of Th17 cells in autoimmune diabetes and generation of a beta cell reporter mouse by lentiviral transgenesis = Lentivirale transgene Technologie zur Erforschung der Rolle von Th17-Zellen im autoimmunen Diabetes und zur Generierung einer Beta-Zell-Reportermaus / Julie Joseph. Betreuer: Stephan Kissler." Würzburg : Universitätsbibliothek der Universität Würzburg, 2011. http://d-nb.info/1018163387/34.

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23

Liu, Shan-Wen, and 劉珊妏. "Development of Fibroblast Growth Factor 1-Trimodal Imaging Reporter transgenic Mouse." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/72026862064222368732.

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24

Imhof, Sascha [Verfasser]. "Endoderm lineage labelling using BAC reporter constructs in ES-cells and mouse embryos / Sascha Imhof." 2009. http://d-nb.info/997767324/34.

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25

Honório, Inês Agapito 1988. "A novel reporter of Fgf5 expression to monitor the "stemness" ground state in mouse embryonic stem cells." Master's thesis, 2011. http://hdl.handle.net/10451/6411.

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Tese de mestrado. Biologia (Biologia Molecular e Genética). Universidade de Lisboa, Faculdade de Ciências, 2011<br>Embryonic stem (ES) cells are characterized by their self-renew and pluripotency properties – the stemness state. A complex gene regulatory network (GRN), with three core transcription factors, NANOG, OCT4 and SOX2 (NOS network), underlies this state, but despite extensive work on this GRN, little is still known about how these factors interact in order to maintain it. Recent work has shown that NANOG expression is heterogeneous in ES cells, while OCT4 and SOX2 seem to be expresse

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26

Joseph, Julie. "Studying the role of Th17 cells in autoimmune diabetes and generation of a beta cell reporter mouse by lentiviral transgenesis." Doctoral thesis, 2011. https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-66571.

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Type 1 diabetes affects around 0.5% of the population in developed countries and the incidence rates have been rising over the years. The destruction of beta cells is irreversible and the current therapy available to patients only manages the symptoms and does not prevent the associated pathological manifestations. The patients need lifelong therapy and intensive research is being carried out to identify ways to eliminate autoimmune responses directed against pancreatic beta cells and to replace or regenerate beta cells. The work presented herein aimed at analyzing the role of the Th17 T cell

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27

Bellemare, Lisa. "IL-23 receptor and IL-12 receptor expression is restricted to distinct cell types in the IL-23R-GFP reporter mouse." Thèse, 2013. http://hdl.handle.net/1866/9679.

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Les maladies inflammatoires de l'intestin (MII) sont caractérisées par des réponses immunitaires incontrôlées dans l'intestin. Des études génétiques ont associé un polymorphisme dans le gène de l'IL23R à la résistance aux MII. IL23R code pour la protéine de l’IL-23r, une sous-unité du récepteur à l’IL-23 (IL-23R). Ce récepteur appartient à la famille de l’IL-12R, contenant plusieurs récepteurs hétérodimériques. D’ailleurs, IL-12R et IL-23R partagent la sous-unité IL12Rb1. Néanmoins, ces deux récepteurs favorisent des réponses immunitaires distinctes (Th1 vs Th17). Ce mémoire caractérise les

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28

Cordeiro, Marília Henriques. "Generation of a VASA/GDF-9/ZP3-promoter driven triple transgenic reporter mouse line as a tool to study ovarian dynamics." Doctoral thesis, 2015. http://hdl.handle.net/10316/27226.

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Tese de doutoramento em Biociências, ramo de especialização em Biologia Celular e Molecular, apresentada à Faculdade de Ciências e Tecnologia da Universidade de Coimbra<br>Neste estudo foi criada, caracterizada uma nova linha de ratinhos transgénicos, posteriormente usada como ferramenta para explicar o papel da anatomia do ovário no estabelecimento da primeira onda de activação folicular. Neste ratinho, promotores exclusivamente expressos no oócito (Vasa, Gdf9 e Zp3) foram usados para controlar a expressão de três proteínas fluorescentes (EGFP, mCherry e AmCyan, respectivamente), criando uma

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