Academic literature on the topic 'Repressilator'

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Journal articles on the topic "Repressilator"

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BULDÚ, JAVIER M., JORDI GARCÍA-OJALVO, ALEXANDRE WAGEMAKERS, and MIGUEL A. F. SANJUÁN. "ELECTRONIC DESIGN OF SYNTHETIC GENETIC NETWORKS." International Journal of Bifurcation and Chaos 17, no. 10 (2007): 3507–11. http://dx.doi.org/10.1142/s0218127407019275.

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We propose the use of nonlinear electronic circuits to study synthetic gene regulation networks. Specifically, we have designed two electronic versions of a synthetic genetic clock, known as the "repressilator," making use of appropriate electronic elements linked in the same way as the original biochemical system. We study the effects of coupling in a population of electronic repressilators, with the aim of observing coherent oscillations of the whole population. With these results, we show that this kind of nonlinear circuits can be helpful in the design and understanding of synthetic geneti
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Oliveira, Samuel M. D., Jerome G. Chandraseelan, Antti Häkkinen, et al. "Single-cell kinetics of a repressilator when implemented in a single-copy plasmid." Molecular BioSystems 11, no. 7 (2015): 1939–45. http://dx.doi.org/10.1039/c5mb00012b.

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BUŞE, OLGUŢA, ALEXEY KUZNETSOV, and RODRIGO A. PÉREZ. "EXISTENCE OF LIMIT CYCLES IN THE REPRESSILATOR EQUATIONS." International Journal of Bifurcation and Chaos 19, no. 12 (2009): 4097–106. http://dx.doi.org/10.1142/s0218127409025237.

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The Repressilator is a genetic regulatory network used to model oscillatory behavior of more complex regulatory networks like the circadian clock. We prove that the Repressilator equations undergo a supercritical Hopf bifurcation as the maximal rate of protein synthesis increases, and find a large range of parameters for which there is a cycle.
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Ushikubo, T., W. Inoue, M. Yoda, and M. Sasai. "3P287 Stochastic Dynamics of Repressilator." Seibutsu Butsuri 44, supplement (2004): S261. http://dx.doi.org/10.2142/biophys.44.s261_3.

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Dukarić, Maša, Hassan Errami, Roman Jerala, et al. "On three genetic repressilator topologies." Reaction Kinetics, Mechanisms and Catalysis 126, no. 1 (2018): 3–30. http://dx.doi.org/10.1007/s11144-018-1519-5.

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Borg, Yanika, Ekkehard Ullner, Afnan Alagha, Ahmed Alsaedi, Darren Nesbeth, and Alexey Zaikin. "Complex and unexpected dynamics in simple genetic regulatory networks." International Journal of Modern Physics B 28, no. 14 (2014): 1430006. http://dx.doi.org/10.1142/s0217979214300060.

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One aim of synthetic biology is to construct increasingly complex genetic networks from interconnected simpler ones to address challenges in medicine and biotechnology. However, as systems increase in size and complexity, emergent properties lead to unexpected and complex dynamics due to nonlinear and nonequilibrium properties from component interactions. We focus on four different studies of biological systems which exhibit complex and unexpected dynamics. Using simple synthetic genetic networks, small and large populations of phase-coupled quorum sensing repressilators, Goodwin oscillators,
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Müller, Stefan, Josef Hofbauer, Lukas Endler, Christoph Flamm, Stefanie Widder, and Peter Schuster. "A generalized model of the repressilator." Journal of Mathematical Biology 53, no. 6 (2006): 905–37. http://dx.doi.org/10.1007/s00285-006-0035-9.

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Kuznetsov, A., and V. Afraimovich. "Heteroclinic cycles in the repressilator model." Chaos, Solitons & Fractals 45, no. 5 (2012): 660–65. http://dx.doi.org/10.1016/j.chaos.2012.02.009.

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Golubyatnikov, Vladimir Petrovich. "Questions of the existence of a stable cycle in one model of a molecular repressor." Mathematical structures and modeling, no. 2 (2017): 59–67. https://doi.org/10.24147/2222-8772.2017.2.59-67.

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A nonlinear six-dimensional dynamic system simulating the functioning of the simplest molecular repressilator is considered. Sufficient conditions for the existence of a stable cycle in its phase portrait are established.
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Knotz, Gabriel, Ulrich Parlitz, and Stefan Klumpp. "Synchronization of a genetic oscillator with the cell division cycle." New Journal of Physics 24, no. 3 (2022): 033050. http://dx.doi.org/10.1088/1367-2630/ac5c16.

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Abstract Genetic circuits that control specific cellular functions are never fully insulated against influences of other parts of the cell. For example, they are subject to periodic modulation by the cell cycle through volume growth and gene doubling. To investigate possible effects of the cell cycle on oscillatory gene circuits dynamics, we modelled a simple synthetic genetic oscillator, the repressilator, and studied hallmarks of the resulting nonlinear dynamics. We found that the repressilator coupled to the cell cycle shows typical quasiperiodic motion with discrete Fourier spectra and win
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Dissertations / Theses on the topic "Repressilator"

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Fryett, Matthew. "The stochastic multi-cellular repressilator." Thesis, University of Aberdeen, 2014. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=211418.

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The discovery of genetic regulatory networks was an important advancement in science. Not only do they help understand how organisms behave but the development of synthetic genetic networks has aided in other fields of science and industry. Many genetic networks have been modelled deterministically by using differential equations to provide an insight into the network's behaviour. However, within a biological environment, a certain degree of intrinsic noise should be expected and the robustness of these networks should be tested. Creating and analysing a genetic network in a biological environ
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Sun, Honglu. "Identifying and Analyzing Long-term Dynamical Behaviors of Gene Regulatory Networks with Hybrid Modeling." Electronic Thesis or Diss., Ecole centrale de Nantes, 2023. http://www.theses.fr/2023ECDN0043.

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Utiliser des modèles dynamiques pour révéler les propriétés dynamiques des réseaux de régulation des gènes peut nous aider à mieux comprendre la nature de ces systèmes biologiques et à développer nouveaux traitements médicaux. Dans cette thèse, nous nous concentrons sur une classe de systèmes dynamiques hybrides appelés réseaux de régulation des gènes hybrides (HGRN) et visons à analyser les propriétés dynamiques à long terme. Nous proposons des méthodes pour trouver des cycles limites et analyser leur stabilité, et pour analyser l’accessibilité dans HGRNs. Ceci est suivi d’une étude plus appr
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Book chapters on the topic "Repressilator"

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Lei, Jinzhi. "Repressilator and Oscillating Network." In Encyclopedia of Systems Biology. Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4419-9863-7_530.

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Sun, Honglu, Maxime Folschette, and Morgan Magnin. "Condition for Periodic Attractor in 4-Dimensional Repressilators." In Computational Methods in Systems Biology. Springer Nature Switzerland, 2023. http://dx.doi.org/10.1007/978-3-031-42697-1_13.

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"Repressilator." In Encyclopedia of Genetics, Genomics, Proteomics and Informatics. Springer Netherlands, 2008. http://dx.doi.org/10.1007/978-1-4020-6754-9_14446.

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Murray, Richard M. "Biological Circuit Components." In Biomolecular Feedback Systems. Princeton University Press, 2014. http://dx.doi.org/10.23943/princeton/9780691161532.003.0005.

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This chapter describes some simple circuit components that have been constructed in E. coli cells using the technology of synthetic biology and then considers a more complicated circuit that already appears in natural systems to implement adaptation. It first analyzes the negatively autoregulated gene fabricated in E. coli bacteria, before turning to the toggle switch, which is composed of two genes that mutually repress each other. The chapter next illustrates a dynamical model of a “repressilator”—an oscillatory genetic circuit consisting of three repressors arranged in a ring fashion. The a
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Conference papers on the topic "Repressilator"

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"Hidden attractors in models of molecular repressilator." In Биоинформатика регуляции и структуры геномов / системная биология. ИЦиГ СО РАН, 2024. http://dx.doi.org/10.18699/bgrs2024-12.1-06.

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Kablar, Natasa A., Vlada Kvrgic, and Dragomir Ilic. "Nonlinear mathematical model of repressilator. Approximation to singular and singularly impulsive dynamical system." In 2012 24th Chinese Control and Decision Conference (CCDC). IEEE, 2012. http://dx.doi.org/10.1109/ccdc.2012.6244016.

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Sun, Honglu, Jean-Paul Comet, Maxime Folschette, and Morgan Magnin. "Condition for Sustained Oscillations in Repressilator Based on a Hybrid Modeling of Gene Regulatory Networks." In 14th International Conference on Bioinformatics Models, Methods and Algorithms. SCITEPRESS - Science and Technology Publications, 2023. http://dx.doi.org/10.5220/0011614300003414.

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Strelkowa, Natalja, and Mauricio Barahona. "Stochastic oscillatory dynamics of generalized repressilators." In NUMERICAL ANALYSIS AND APPLIED MATHEMATICS ICNAAM 2012: International Conference of Numerical Analysis and Applied Mathematics. AIP, 2012. http://dx.doi.org/10.1063/1.4756221.

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Wu, Yu, and Junhui Gao. "Numerical Imitation of the Synchronization of Gene Repressilators." In 2015 International Conference on Modeling, Simulation and Applied Mathematics. Atlantis Press, 2015. http://dx.doi.org/10.2991/msam-15.2015.41.

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Liu, Zexing, Xian Zhang, and Xin Wang. "Global Exponential Stability of Delayed Coupled Repressilators in Artificial Oscillatory Networks." In 2019 IEEE 58th Conference on Decision and Control (CDC). IEEE, 2019. http://dx.doi.org/10.1109/cdc40024.2019.9029465.

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"SYNCHRONISATION OF BIOLOGICAL CLOCK SIGNALS - Capturing Coupled Repressilators from a Control Systems Perspective." In International Conference on Bio-inspired Systems and Signal Processing. SciTePress - Science and and Technology Publications, 2011. http://dx.doi.org/10.5220/0003121301010106.

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Reports on the topic "Repressilator"

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Udyavar, Nehal, and Niko McCarty. The Making of a Gene Circuit. Asimov Press, 2025. https://doi.org/10.62211/23ey-67yy.

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