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1

Simkus, Andrea, Frank PA Coolen, Tahani Coolen-Maturi, Natasha A. Karp, and Claus Bendtsen. "Statistical reproducibility for pairwise t-tests in pharmaceutical research." Statistical Methods in Medical Research 31, no. 4 (2021): 673–88. http://dx.doi.org/10.1177/09622802211041765.

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This paper investigates statistical reproducibility of the [Formula: see text]-test. We formulate reproducibility as a predictive inference problem and apply the nonparametric predictive inference method. Within our research framework, statistical reproducibility provides inference on the probability that the same test outcome would be reached, if the test were repeated under identical conditions. We present an nonparametric predictive inference algorithm to calculate the reproducibility of the [Formula: see text]-test and then use simulations to explore the reproducibility both under the null
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Fary, Camdon, Dean McKenzie, and Richard de Steiger. "Reproducibility of an Intraoperative Pressure Sensor in Total Knee Replacement." Sensors 21, no. 22 (2021): 7679. http://dx.doi.org/10.3390/s21227679.

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Appropriate soft tissue tension in total knee replacement (TKR) is an important factor for a successful outcome. The purpose of our study was to assess both the reproducibility of a modern intraoperative pressure sensor (IOP) and if a surgeon could unconsciously influence measurement. A consecutive series of 80 TKRs were assessed with an IOP between January 2018 and December 2020. In the first scenario, two blinded sequential measurements in 48 patients were taken; in a second scenario, an initial blinded measurement and a subsequent unblinded measurement in 32 patients were taken while lookin
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Hearn, Jeff. "Sexualities, organizations and organization sexualities: Future scenarios and the impact of socio-technologies (a transnational perspective from the global ‘north’)." Organization 21, no. 3 (2014): 400–420. http://dx.doi.org/10.1177/1350508413519764.

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The article opens by briefly reviewing studies of sexuality in and around organizations from the 1970s. These studies showed considerable theoretical, empirical and conceptual development, as in the concept of organization sexuality. Building on this, the article’s first task is to analyse alternative future scenarios for organization sexualities, by way of changing intersections of gender, sexuality and organizational forms. Possible gendered future scenarios are outlined based on, first, gender equality/inequality and, second, gender similarity/difference between women, men and further gende
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Shu, Lele, Paul Ullrich, Xianhong Meng, Christopher Duffy, Hao Chen, and Zhaoguo Li. "rSHUD v2.0: advancing the Simulator for Hydrologic Unstructured Domains and unstructured hydrological modeling in the R environment." Geoscientific Model Development 17, no. 2 (2024): 497–527. http://dx.doi.org/10.5194/gmd-17-497-2024.

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Abstract. Hydrological modeling is a crucial component in hydrology research, particularly for projecting future scenarios. However, achieving reproducibility and automation in distributed hydrological modeling research for modeling, simulation, and analysis is challenging. This paper introduces rSHUD v2.0, an innovative, open-source toolkit developed in the R environment to enhance the deployment and analysis of the Simulator for Hydrologic Unstructured Domains (SHUD). The SHUD is an integrated surface–subsurface hydrological model that employs a finite-volume method to simulate hydrological
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Hafizi, Hamed, and Ali Arda Sorman. "Integrating Meteorological Forcing from Ground Observations and MSWX Dataset for Streamflow Prediction under Multiple Parameterization Scenarios." Water 14, no. 17 (2022): 2721. http://dx.doi.org/10.3390/w14172721.

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Precipitation and near-surface air temperatures are significant meteorological forcing for streamflow prediction where most basins are partially or fully data-scarce in many parts of the world. This study aims to evaluate the consistency of MSWXv100-based precipitation, temperatures, and estimated potential evapotranspiration (PET) by direct comparison with observed measurements and by utilizing an independent combination of MSWXv100 dataset and observed data for streamflow prediction under four distinct scenarios considering model parameter and output uncertainties. Initially, the model is ca
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Mazzorana, B., J. Hübl, and S. Fuchs. "Improving risk assessment by defining consistent and reliable system scenarios." Natural Hazards and Earth System Sciences 9, no. 1 (2009): 145–59. http://dx.doi.org/10.5194/nhess-9-145-2009.

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Abstract. During the entire procedure of risk assessment for hydrologic hazards, the selection of consistent and reliable scenarios, constructed in a strictly systematic way, is fundamental for the quality and reproducibility of the results. However, subjective assumptions on relevant impact variables such as sediment transport intensity on the system loading side and weak point response mechanisms repeatedly cause biases in the results, and consequently affect transparency and required quality standards. Furthermore, the system response of mitigation measures to extreme event loadings represe
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Refaee, Turkey, Zohaib Salahuddin, Yousif Widaatalla, et al. "CT Reconstruction Kernels and the Effect of Pre- and Post-Processing on the Reproducibility of Handcrafted Radiomic Features." Journal of Personalized Medicine 12, no. 4 (2022): 553. http://dx.doi.org/10.3390/jpm12040553.

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Handcrafted radiomics features (HRFs) are quantitative features extracted from medical images to decode biological information to improve clinical decision making. Despite the potential of the field, limitations have been identified. The most important identified limitation, currently, is the sensitivity of HRF to variations in image acquisition and reconstruction parameters. In this study, we investigated the use of Reconstruction Kernel Normalization (RKN) and ComBat harmonization to improve the reproducibility of HRFs across scans acquired with different reconstruction kernels. A set of pha
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Tripathi, Veenu, and Stefano Caizzone. "Virtual Validation of In-Flight GNSS Signal Reception during Jamming for Aeronautics Applications." Aerospace 11, no. 3 (2024): 204. http://dx.doi.org/10.3390/aerospace11030204.

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Accurate navigation is a crucial asset for safe aviation operation. The GNSS (Global Navigation Satellite System) is set to play an always more important role in aviation but needs to cope with the risk of interference, possibly causing signal disruption and loss of navigation capability. It is crucial, therefore, to evaluate the impact of interference events on the GNSS system on board an aircraft, in order to plan countermeasures. This is currently obtained through expensive and time-consuming flight measurement campaigns. This paper shows on the other hand, a method developed to create a vi
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Santana-Perez, Idafen, and María S. Pérez-Hernández. "Towards Reproducibility in Scientific Workflows: An Infrastructure-Based Approach." Scientific Programming 2015 (2015): 1–11. http://dx.doi.org/10.1155/2015/243180.

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It is commonly agreed that in silico scientific experiments should be executable and repeatable processes. Most of the current approaches for computational experiment conservation and reproducibility have focused so far on two of the main components of the experiment, namely, data and method. In this paper, we propose a new approach that addresses the third cornerstone of experimental reproducibility: the equipment. This work focuses on the equipment of a computational experiment, that is, the set of software and hardware components that are involved in the execution of a scientific workflow.
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Lee, Daeeop, Giha Lee, Seongwon Kim, and Sungho Jung. "Future Runoff Analysis in the Mekong River Basin under a Climate Change Scenario Using Deep Learning." Water 12, no. 6 (2020): 1556. http://dx.doi.org/10.3390/w12061556.

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In establishing adequate climate change policies regarding water resource development and management, the most essential step is performing a rainfall-runoff analysis. To this end, although several physical models have been developed and tested in many studies, they require a complex grid-based parameterization that uses climate, topography, land-use, and geology data to simulate spatiotemporal runoff. Furthermore, physical rainfall-runoff models also suffer from uncertainty originating from insufficient data quality and quantity, unreliable parameters, and imperfect model structures. As an al
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Huppmann, Daniel, Matthew J. Gidden, Zebedee Nicholls, et al. "pyam: Analysis and visualisation of integrated assessment and macro-energy scenarios." Open Research Europe 1 (June 28, 2021): 74. http://dx.doi.org/10.12688/openreseurope.13633.1.

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The open-source Python package pyam provides a suite of features and methods for the analysis, validation and visualization of reference data and scenario results generated by integrated assessment models, macro-energy tools and other frameworks in the domain of energy transition, climate change mitigation and sustainable development. It bridges the gap between scenario processing and visualisation solutions that are "hard-wired" to specific modelling frameworks and generic data analysis or plotting packages. The package aims to facilitate reproducibility and reliability of scenario processing
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Grammer, Robert T. "Quantitation & Case-Study-Driven Inquiry to Enhance Yeast Fermentation Studies." American Biology Teacher 74, no. 6 (2012): 414–20. http://dx.doi.org/10.1525/abt.2012.74.6.10.

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We propose a procedure for the assay of fermentation in yeast in microcentrifuge tubes that is simple and rapid, permitting assay replicates, descriptive statistics, and the preparation of line graphs that indicate reproducibility. Using regression and simple derivatives to determine initial velocities, we suggest methods to compare the effects of experimental variables. This technique is straightforward enough to facilitate design of an inquiry lab based on a scenario that explores modifications to enhance the rate of fermentation.
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Álvarez-Alonso, Cristina, María Dolores Pérez-Murcia, Silvia Sánchez-Méndez, et al. "Municipal Solid Waste Management in a Decentralized Composting Scenario: Assessment of the Process Reproducibility and Quality of the Obtained Composts." Agronomy 14, no. 1 (2023): 54. http://dx.doi.org/10.3390/agronomy14010054.

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Over the last several years, the models for organic waste management have changed to implement circular economy in the productive cycle. In this context, new scenarios have emerged, where the management of different organic waste streams by composting is conducted with decentralized models that manage organic wastes in a more local way. However, in these new models, the standardization of the process control and of the end-product characteristics is necessary to guarantee the quality and agronomic value of the compost obtained, avoiding potential risks for human health and the environment. Thu
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Wercelens, Polyane, Waldeyr da Silva, Fernanda Hondo, et al. "Bioinformatics Workflows With NoSQL Database in Cloud Computing." Evolutionary Bioinformatics 15 (January 2019): 117693431988997. http://dx.doi.org/10.1177/1176934319889974.

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Scientific workflows can be understood as arrangements of managed activities executed by different processing entities. It is a regular Bioinformatics approach applying workflows to solve problems in Molecular Biology, notably those related to sequence analyses. Due to the nature of the raw data and the in silico environment of Molecular Biology experiments, apart from the research subject, 2 practical and closely related problems have been studied: reproducibility and computational environment. When aiming to enhance the reproducibility of Bioinformatics experiments, various aspects should be
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Huppmann, Daniel, Matthew J. Gidden, Zebedee Nicholls, et al. "pyam: Analysis and visualisation of integrated assessment and macro-energy scenarios." Open Research Europe 1 (September 1, 2021): 74. http://dx.doi.org/10.12688/openreseurope.13633.2.

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The open-source Python package pyam provides a suite of features and methods for the analysis, validation and visualization of reference data and scenario results generated by integrated assessment models, macro-energy tools and other frameworks in the domain of energy transition, climate change mitigation and sustainable development. It bridges the gap between scenario processing and visualisation solutions that are "hard-wired" to specific modelling frameworks and generic data analysis or plotting packages. The package aims to facilitate reproducibility and reliability of scenario processing
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McCarroll, Rachel E., Beth M. Beadle, Danna Fullen, et al. "Reproducibility of patient setup in the seated treatment position: A novel treatment chair design." Journal of Applied Clinical Medical Physics 18, no. 1 (2017): 223–29. http://dx.doi.org/10.1002/acm2.12024.

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AbstractRadiotherapy in a seated position may be indicated for patients who are unable to lie on the treatment couch for the duration of treatment, in scenarios where a seated treatment position provides superior anatomical positioning and dose distributions, or for a low‐cost system designed using a fixed treatment beam and rotating seated patient. In this study, we report a novel treatment chair that was constructed to allow for three‐dimensional imaging and treatment delivery while ensuring robust immobilization, providing reproducibility equivalent to that in the traditional supine positio
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Akamatsu, Shusuke, Ryo Takata, Atsushi Takahashi, et al. "Reproducibility, performance, and clinical utility of a genetic risk prediction model for prostate cancer in Japanese patients." Journal of Clinical Oncology 30, no. 15_suppl (2012): 10520. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.10520.

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10520 Background: Prostate specific antigen (PSA) is widely used as a diagnostic biomarker for prostate cancer (PC). However, due to its low predictive performance, many patients without PC suffer from the harms of unnecessary prostate needle biopsies. The present study aims to evaluate the reproducibility and performance of a genetic risk prediction model and estimate its utility as a diagnostic biomarker in a clinical scenario. Methods: We created a logistic regression model incorporating 16 SNPs that were significantly associated with PC in a genome-wide association study of the Japanese. T
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Stauffer, Glenn E., Erik R. Olson, Jerrold L. Belant, et al. "Uncertainty and precaution in hunting wolves twice in a year: Reanalysis of Treves and Louchouarn." PLOS ONE 19, no. 6 (2024): e0301487. http://dx.doi.org/10.1371/journal.pone.0301487.

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Management of wolves is controversial in many jurisdictions where wolves live, which underscores the importance of rigor, transparency, and reproducibility when evaluating outcomes of management actions. Treves and Louchouarn 2022 (hereafter TL) predicted outcomes for various fall 2021 hunting scenarios following Wisconsin’s judicially mandated hunting and trapping season in spring 2021, and concluded that even a zero harvest scenario could result in the wolf population declining below the population goal of 350 wolves specified in the 1999 Wisconsin wolf management plan. TL further concluded
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Fabbri, Rachele, Ludovica Cacopardo, Arti Ahluwalia, and Chiara Magliaro. "Advanced 3D Models of Human Brain Tissue Using Neural Cell Lines: State-of-the-Art and Future Prospects." Cells 12, no. 8 (2023): 1181. http://dx.doi.org/10.3390/cells12081181.

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Human-relevant three-dimensional (3D) models of cerebral tissue can be invaluable tools to boost our understanding of the cellular mechanisms underlying brain pathophysiology. Nowadays, the accessibility, isolation and harvesting of human neural cells represents a bottleneck for obtaining reproducible and accurate models and gaining insights in the fields of oncology, neurodegenerative diseases and toxicology. In this scenario, given their low cost, ease of culture and reproducibility, neural cell lines constitute a key tool for developing usable and reliable models of the human brain. Here, w
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Son, Weonil, Yunchul Ha, Taeyoung Oh, Seunghoon Woo, Sungwoo Cho, and Jinwoo Yoo. "PG-Based Vehicle-In-the-Loop Simulation for System Development and Consistency Validation." Electronics 11, no. 24 (2022): 4073. http://dx.doi.org/10.3390/electronics11244073.

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The concern over safety features in autonomous vehicles is increasing due to the rapid development and increasing use of autonomous driving technology. The safety evaluations performed for an autonomous driving system cannot depend only on existing safety verification methods, due to the lack of scenario reproducibility and the dynamic characteristics of the vehicle. Vehicle-In-the-Loop Simulation (VILS) utilizes both real vehicles and virtual simulations for the driving environment to overcome these drawbacks and is a suitable candidate for ensuring reproducibility. However, there may be diff
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Csippa, Benjamin, Dániel Gyürki, Gábor Závodszky, István Szikora, and György Paál. "Hydrodynamic Resistance of Intracranial Flow-Diverter Stents: Measurement Description and Data Evaluation." Cardiovascular Engineering and Technology 11, no. 1 (2019): 1–13. http://dx.doi.org/10.1007/s13239-019-00445-y.

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Abstract Purpose Intracranial aneurysms are malformations forming bulges on the walls of brain arteries. A flow diverter device is a fine braided wire structure used for the endovascular treatment of brain aneurysms. This work presents a rig and a protocol for the measurement of the hydrodynamic resistance of flow diverter stents. Hydrodynamic resistance is interpreted here as the pressure loss versus volumetric flow rate function through the mesh structure. The difficulty of the measurement is the very low flow rate range and the extreme sensitivity to contamination and disturbances. Methods
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Michel, Nicolas, Giovanni Chierchia, Romain Negrel, and Jean-François Bercher. "Learning Representations on the Unit Sphere: Investigating Angular Gaussian and Von Mises-Fisher Distributions for Online Continual Learning." Proceedings of the AAAI Conference on Artificial Intelligence 38, no. 13 (2024): 14350–58. http://dx.doi.org/10.1609/aaai.v38i13.29348.

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We use the maximum a posteriori estimation principle for learning representations distributed on the unit sphere. We propose to use the angular Gaussian distribution, which corresponds to a Gaussian projected on the unit-sphere and derive the associated loss function. We also consider the von Mises-Fisher distribution, which is the conditional of a Gaussian in the unit-sphere. The learned representations are pushed toward fixed directions, which are the prior means of the Gaussians; allowing for a learning strategy that is resilient to data drift. This makes it suitable for online continual le
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Lopes, Rônney Pinto, Vivian Dias Baptista Gagliardi, Felipe Torres Pacheco, and Rubens José Gagliardi. "Ischemic stroke with unknown onset of symptoms: current scenario and perspectives for the future." Arquivos de Neuro-Psiquiatria 80, no. 12 (2022): 1262–73. http://dx.doi.org/10.1055/s-0042-1755342.

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Abstract Background Stroke is a major cause of disability worldwide and a neurological emergency. Intravenous thrombolysis and mechanical thrombectomy are effective in the reperfusion of the parenchyma in distress, but the impossibility to determine the exact time of onset was an important cause of exclusion from treatment until a few years ago. Objectives To review the clinical and radiological profile of patients with unknown-onset stroke, the imaging methods to guide the reperfusion treatment, and suggest a protocol for the therapeutic approach. Methods The different imaging methods were gr
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Niero, Giovanni, Filippo Cendron, Mauro Penasa, Massimo De Marchi, Giulio Cozzi, and Martino Cassandro. "Repeatability and Reproducibility of Measures of Bovine Methane Emissions Recorded using a Laser Detector." Animals 10, no. 4 (2020): 606. http://dx.doi.org/10.3390/ani10040606.

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Methane (CH4) emissions represent a worldwide problem due to their direct involvement in atmospheric warming and climate change. Ruminants are among the major players in the global scenario of CH4 emissions, and CH4 emissions are a problem for feed efficiency since enteric CH4 is eructed to the detriment of milk and meat production. The collection of CH4 phenotypes at the population level is still hampered by costly and time-demanding techniques. In the present study, a laser methane detector was used to assess repeatability and reproducibility of CH4 phenotypes, including mean and aggregate o
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Wang, Lujia, Hyunsoo Yoon, Andrea Hawkins-Daarud, et al. "NIMG-30. REPRODUCIBLE RADIOMIC MAPPING OF TUMOR CELL DENSITY BY MACHINE LEARNING AND DOMAIN ADAPTATION." Neuro-Oncology 21, Supplement_6 (2019): vi167. http://dx.doi.org/10.1093/neuonc/noz175.700.

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Abstract BACKGROUND An important challenge in radiomics research is reproducibility. Images are collected on different image scanners and protocols, which introduces significant variability even for the same type of image across institutions. In the present proof-of-concept study, we address the reproducibility issue by using domain adaptation – an algorithm that transforms the radiomic features of each new patient to align with the distribution of features formed by the patient samples in a training set. METHOD Our dataset included 18 patients in training with a total of 82 biopsy sample. The
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Kiamanesh, Bahareh, Ali Behravan, and Roman Obermaisser. "Realistic Simulation of Sensor/Actuator Faults for a Dependability Evaluation of Demand-Controlled Ventilation and Heating Systems." Energies 15, no. 8 (2022): 2878. http://dx.doi.org/10.3390/en15082878.

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In the development of fault-tolerant systems, simulation is a common technique used to obtain insights into performance and dependability because it saves time and avoids the risks of testing the behavior of real-world systems in the presence of faults. Fault injection in a simulation offers a high controllability and observability, and thus is ideal for an early dependability analysis and fault-tolerance evaluation. Heating, ventilation, and air conditioning (HVAC) systems in critical infrastructures, such as airports and hospitals, are safety-relevant systems, which not only determine energy
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Hinz, Matthias, Nico Lehmann, Kevin Melcher, et al. "Reliability of Perceptual-Cognitive Skills in a Complex, Laboratory-Based Team-Sport Setting." Applied Sciences 11, no. 11 (2021): 5203. http://dx.doi.org/10.3390/app11115203.

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The temporal occlusion paradigm is often used in anticipation and decision-making research in sports. Although it is considered as a valid measurement tool, evidence of its reproducibility is lacking but required for future cross-sectional and repeated-measures designs. Moreover, only a few studies on decision making in real-world environments exist. Here, we aimed at (a) implementing a temporal occlusion test with multi-dimensional motor response characteristics, and (b) assessing intra- and inter-session item reliability. Temporally occluded videos of attack sequences in a team handball scen
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Vigliar, Elena, Umberto Malapelle, Francesca Bono, et al. "The Reproducibility of the Immunohistochemical PD-L1 Testing in Non-Small-Cell Lung Cancer: A Multicentric Italian Experience." BioMed Research International 2019 (April 14, 2019): 1–7. http://dx.doi.org/10.1155/2019/6832909.

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An important harmonization effort was produced by the scientific community to standardize both the preanalytical and interpretative phases of programmed death-ligand 1 (PD-L1) immunohistochemical (IHC) testing in non-small-cell lung cancer (NSCLC). This analysis is crucial for the selection of patients with advanced-stage tumors eligible for treatment with pembrolizumab and potentially with other anti-PD-1/PD-L1 checkpoint inhibitors. This multicentric retrospective study evaluated the reproducibility of PD-L1 testing in the Italian scenario both for closed and open platforms. In the evaluatio
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Martinez, Juana M. Plasencia, Jose M. Garcia Santos, Maria L. Paredes Marti­nez, and Ana Moreno Pastor. "Carotid intima-media thickness and hemodynamic parameters: reproducibility of manual measurements with Doppler ultrasound." Medical Ultrasonography 17, no. 2 (2015): 167. http://dx.doi.org/10.11152/mu.2013.2066.172.ci-m.

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Aims: To evaluate the carotid ultrasound intra- and interobserver agreements in a common clinical scenario when making manual measurements of the intima-media thickness (IMT) and peak systolic (PSV) and end diastolic (EDV) velocities in the common (CCA) and the internal carotid (ICA) arteries. Material and methods: Three different experienced operators per- formed two time-point carotid ultrasounds in 21 patients with cardiovascular risk factors. Each operator measured freehand the CCA IMT three consecutive times in each examination. The CCA and ICA hemodynamic parameters were acquired just on
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Staziaki, Pedro Vinícius, Rutuparna Sarangi, Ujas N. Parikh, Jeffrey G. Brooks, Christina Alexandra LeBedis, and Kitt Shaffer. "An Objective Structured Clinical Examination for Medical Student Radiology Clerkships: Reproducibility Study." JMIR Medical Education 6, no. 1 (2020): e15444. http://dx.doi.org/10.2196/15444.

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Background Objective structured clinical examinations (OSCEs) are a useful method to evaluate medical students’ performance in the clerkship years. OSCEs are designed to assess skills and knowledge in a standardized clinical setting and through use of a preset standard grading sheet, so that clinical knowledge can be evaluated at a high level and in a reproducible way. Objective This study aimed to present our OSCE assessment tool designed specifically for radiology clerkship medical students, which we called the objective structured radiology examination (OSRE), with the intent to advance the
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Mangampadath, Abhilash. "Introspection into the Guna Wisdom of Ayurveda–A Review From the Clinical Perspective." International Research Journal of Ayurveda & Yoga 05, no. 02 (2022): 155–60. http://dx.doi.org/10.47223/irjay.2022.5228.

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The clinical scenario in Ayurveda is currently positioned at a juncture where there is immense demand for standardization and development. Researchers are running after the methods to tackle the issues of individual variations and lack of reproducibility when it comes to the systematic practice of Ayurveda. Under these circumstances, the guna spectrum in Ayurveda, often neglected as a philosophical area that do not have direct clinical applications needs to be revived so that the quintessence of Ayurvedic clinical decision making is translated into the research arena. For this purpose, a thoro
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Balboni, Andrea, Laura Gallina, Alessandra Palladini, Santino Prosperi, and Mara Battilani. "A Real-Time PCR Assay for Bat SARS-Like Coronavirus Detection and Its Application to Italian Greater Horseshoe Bat Faecal Sample Surveys." Scientific World Journal 2012 (2012): 1–8. http://dx.doi.org/10.1100/2012/989514.

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Bats are source of coronaviruses closely related to the severe acute respiratory syndrome (SARS) virus. Numerous studies have been carried out to identify new bat viruses related to SARS-coronavirus (bat-SARS-like CoVs) using a reverse-transcribed-polymerase chain reaction assay. However, a qualitative PCR could underestimate the prevalence of infection, affecting the epidemiological evaluation of bats in viral ecology. In this work an SYBR Green-real time PCR assay was developed for diagnosing infection with SARS-related coronaviruses from bat guano and was applied as screening tool in a surv
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Nigon, Tyler, Gabriel Dias Paiao, David J. Mulla, Fabián G. Fernández, and Ce Yang. "The Influence of Aerial Hyperspectral Image Processing Workflow on Nitrogen Uptake Prediction Accuracy in Maize." Remote Sensing 14, no. 1 (2021): 132. http://dx.doi.org/10.3390/rs14010132.

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A meticulous image processing workflow is oftentimes required to derive quality image data from high-resolution, unmanned aerial systems. There are many subjective decisions to be made during image processing, but the effects of those decisions on prediction model accuracy have never been reported. This study introduced a framework for quantifying the effects of image processing methods on model accuracy. A demonstration of this framework was performed using high-resolution hyperspectral imagery (<10 cm pixel size) for predicting maize nitrogen uptake in the early to mid-vegetative developm
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Pathak, Ashis, Harman Brar, and Abhishek Puri. "SDPS-11 IMPACT OF MOLECULAR MARKERS USING FISH TECHNIQUE ON GOS/SURVIVAL IN HIGH GRADE GLIOMAS IN INDIAN SCENARIO." Neuro-Oncology Advances 5, Supplement_3 (2023): iii19. http://dx.doi.org/10.1093/noajnl/vdad070.071.

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Abstract Aims Molecular markers (MGMT, IDH and 1p/19q, MIB-1 index, TP53) are used for present day diagnosis of high-grade glial tumours. This study evaluates outcome parameters [e.g., GOS, progression free (PFS) and overall survival(OS)] in treated high grade gliomas in Indian context using FISH technique for molecular characterisation. MATERIALS AND METHODS This study used FISH techniques for IDH, MGMT and other IHC markers prospectively on 10 patients with high-grade gliomas, after safe maximal resection. Outcomes were noted for PFS and OS. A GOS of 1-3 (considered unfavourable); 4-5 (favou
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Ginés Clavero, Jonatan, Francisco Martín Rico, Francisco J. Rodríguez-Lera, José Miguel Guerrero Hernandéz, and Vicente Matellán Olivera. "Impact of decision-making system in social navigation." Multimedia Tools and Applications 81, no. 3 (2022): 3459–81. http://dx.doi.org/10.1007/s11042-021-11454-2.

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AbstractFacing human activity-aware navigation with a cognitive architecture raises several difficulties integrating the components and orchestrating behaviors and skills to perform social tasks. In a real-world scenario, the navigation system should not only consider individuals like obstacles. It is necessary to offer particular and dynamic people representation to enhance the HRI experience. The robot’s behaviors must be modified by humans, directly or indirectly. In this paper, we integrate our human representation framework in a cognitive architecture to allow that people who interact wit
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Brito, Amanda Rodrigues, Mayra do Nascimento Melo, Casandra Genoveva Rosales Martins Ponce de Leon, and Laiane Medeiros Ribeiro. "Cenário simulado com brinquedo terapêutico: uma ferramenta para educação em saúde." Revista Recien - Revista Científica de Enfermagem 12, no. 40 (2022): 200–209. http://dx.doi.org/10.24276/rrecien2022.12.40.200-209.

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Elaborar um cenário simulado com brinquedo terapêutico para uso em educação em saúde e validá-lo. Trata-se de uma pesquisa de desenvolvimento metodológico. Validada de forma remota através de formulário estruturado. Foi calculado o Índice de Validade de Conteúdo e analisado os comentários dos seis especialistas participantes. O cenário “O brinquedo terapêutico para educação em saúde” como meio para orientar o familiar sobre a traqueostomia, o check list de condutas esperadas, o Índice de Validade de Conteúdo de 0,93 e os comentários dos especialistas apontaram para a reprodutibilidade do cenár
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Ma, Li, Erich Peterson, Mathew Steliga, et al. "Abstract 5038: Applying reproducible genomic data science methods for the analysis of a rare tumor type." Cancer Research 82, no. 12_Supplement (2022): 5038. http://dx.doi.org/10.1158/1538-7445.am2022-5038.

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Abstract Background: The new and emerging discipline of data science demands reproducibility, which is vital in science and presents a significant challenge for high throughput genomics. To further complicate matters, large and complex projects require collaboration by multiple investigators examining and analyzing the massive data of multiple genomic modalities from different perspectives. Today, researchers are rarely able to reproduce published genomic studies for a variety of reasons, for example: i) differences between versions of software used, ii) lack of detail regarding software param
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Silva, Thiago de Medeiros Silveira, Aneuri Souza De Amorim, Mario Cesar Viegas Balthar, et al. "Methodology for checking the stability of the Cesium-137 irradiator system of the Radiation Monitors Calibration Laboratory (LabCal) at IDQBRN / Metodologia para verificar a estabilidade do sistema de irradiação Césio-137 do Laboratório de Calibração de Monitores de Radiação (LabCal) no IDQBRN." Brazilian Journal of Development 8, no. 1 (2022): 2813–31. http://dx.doi.org/10.34117/bjdv8n1-186.

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The provision for the Brazilian Army of equipment that provides reliable and safe measurements leads to the need for a metrology study of the calibration system used in the Institute's Radiation Monitor Calibration Laboratory (LabCal) of Chemical, Biological, Radiological and Nuclear Defense (IDQBRN). In order to verify the stability of dosimetry in Cesium-137, the ambient dose equivalent rate, H*(10), was experimentally obtained for certain distance settings and lead attenuators at different dates in order to compare them. To this end, the distance between the source of Cesium-137 and the ion
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Ncube, Mthokozisi, and Akpofure E. Taigbenu. "Assessment of apparent losses due to meter inaccuracy using an alternative, validated methodology." Water Supply 19, no. 4 (2018): 1212–20. http://dx.doi.org/10.2166/ws.2018.178.

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Abstract Despite wide acceptance of the IWA water balance as the basis of managing water losses, experience suggests that there are difficulties with its application. For apparent losses assessment, the traditional approach of deriving consumption profiles and testing water meters exceeds the resources of many utilities. While a few studies have explored alternative methodologies, these have largely not been validated and are susceptible to reproducibility and interpretation difficulties. This paper introduces an improved comparative billing analysis method that combines data preparation techn
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Heggy, Essam, Zane Sharkawy, and Abotalib Z. Abotalib. "Reply to Comment on ‘Egypt’s water budget deficit and suggested mitigation policies for the Grand Ethiopian Renaissance Dam filling scenarios’ by Kevin Wheeler et al’." Environmental Research Letters 17, no. 12 (2022): 128001. http://dx.doi.org/10.1088/1748-9326/ac9c1b.

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Abstract We thank Wheeler et al for positively confirming our results’ reproducibility; however, we show herein that their critique misrepresents the aim, approach, and interpretations reported in Heggy et al (2021 Environ. Res. Lett. 16 074022), which remain valid. The reply herein demonstrates that Wheeler et al incorrectly interpreted Heggy et al’s (2021 Environ. Res. Lett. 16 074022) estimates of the median unmitigated total water budget deficit for Egypt of 31 BCM yr−1 to be entirely caused by GERD. The comment overlooks the fact that this estimated value is the sum of Egypt’s existing in
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Dora, Amy V., Tara Vijayan, and Christopher J. Graber. "1138. Works Well Enough? Program Directors’ Perceptions of the Effectiveness and Transparency of Competency-Based Evaluations in Assessing Infectious Diseases Fellow Performance." Open Forum Infectious Diseases 7, Supplement_1 (2020): S597—S598. http://dx.doi.org/10.1093/ofid/ofaa439.1324.

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Abstract Background In July 2015, the Accreditation Council for Graduate Medical Education (ACGME) and the American Board of Internal Medicine (ABIM) jointly outlined an approach to assessing fellow performance using milestone-based core competencies for incorporation into standardized evaluation templates of trainee performance. Limited data exist regarding the clarity, effectiveness, and reproducibility of competency-based evaluations of infectious diseases fellows. Methods From March to May 2019, program directors of ACGME-accredited infectious diseases fellowship programs were invited to c
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Olarte, Carlos Mario, Mauricio Zuluaga, Adriana Guzman, et al. "Analysis of the experience of the geriatric fracture program in two institutions in Colombia: a reproducible model?" Colombia Medica 52, no. 3 (2021): e2034524. http://dx.doi.org/10.25100/cm.v52i3.4524.

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Background: hip fracture is the major cause of morbidity and mortality. Geriatric fracture programs promise to improve the quality of care, health outcomes and reduce costs.
 Objective: To describe the results related to the Geriatric fracture programs implementation in two Colombian institutions. These results could then be compared to other published experiences to assess reproducibility of the program.
 Methods: A retrospective descriptive study of the patients treated under the Geriatric fracture programs in two institutions in Colombia was carried out. The information of each in
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Mason, Anna Elizabeth, and Murali Varma. "Histopathology reporting for personalised medicine: focus on clinical utility." Journal of Clinical Pathology 75, no. 8 (2022): 525–28. http://dx.doi.org/10.1136/jclinpath-2022-208185.

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Histopathology guidelines generally focus on standardised collection of data items to facilitate completeness and reproducibility of histopathology reporting. A data item is categorised as either core (mandatory) or non-core (recommended but not mandatory), irrespective of the clinical scenario. However, a data item that is critical for patient management in one clinical setting may have little clinical significance in another setting. A diagnosis of limited extent Gleason score 3+3=6 prostate cancer is critical in a patient being investigated for raised serum prostate-specific antigen but wou
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Toutsop, Borel, Benjamin Ducharne, Mickael Lallart, Laurent Morel, and Pierre Tsafack. "Characterization of Tensile Stress-Dependent Directional Magnetic Incremental Permeability in Iron-Cobalt Magnetic Sheet: Towards Internal Stress Estimation through Non-Destructive Testing." Sensors 22, no. 16 (2022): 6296. http://dx.doi.org/10.3390/s22166296.

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Iron-Cobalt ferromagnetic alloys are promoted for electrical energy conversion in aeronautic applications, but their high magnetostrictive coefficients may result in undesired behaviors. Internal stresses can be tuned to limit magnetostriction but must be adequately assessed in a non-destructive way during production. For this, directional magnetic incremental permeability is proposed in this work. For academic purposes, internal stresses have been replaced by homogenous external stress, which is easier to control using traction/compression testbench and results in similar effects. Tests have
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Yang, Kun, Xinkai Xia, Fan Zhang, et al. "Implementation of a Sponge-Based Flexible Electronic Skin for Safe Human–Robot Interaction." Micromachines 13, no. 8 (2022): 1344. http://dx.doi.org/10.3390/mi13081344.

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In current industrial production, robots have increasingly been taking the place of manual workers. With the improvements in production efficiency, accidents that involve operators occur frequently. In this study, a flexible sensor system was designed to promote the security performance of a collaborative robot. The flexible sensors, which was made by adsorbing graphene into a sponge, could accurately convert the pressure on a contact surface into a numerical signal. Ecoflex was selected as the substrate material for our sensing array so as to enable the sensors to better adapt to the sensing
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Cerroni, Rocco, Daniele Pietrucci, Adelaide Teofani, et al. "Not just a Snapshot: An Italian Longitudinal Evaluation of Stability of Gut Microbiota Findings in Parkinson’s Disease." Brain Sciences 12, no. 6 (2022): 739. http://dx.doi.org/10.3390/brainsci12060739.

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Most research analyzed gut-microbiota alterations in Parkinson’s disease (PD) through cross-sectional studies, as single snapshots, without considering the time factor to either confirm methods and findings or observe longitudinal variations. In this study, we introduce the time factor by comparing gut-microbiota composition in 18 PD patients and 13 healthy controls (HC) at baseline and at least 1 year later, also considering PD clinical features. PD patients and HC underwent a fecal sampling at baseline and at a follow-up appointment. Fecal samples underwent sequencing and 16S rRNA amplicons
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Carrillo-Ávila, José Antonio, Purificación Catalina, and Rocío Aguilar-Quesada. "Quality Control of Cell Lines Using DNA as Target." DNA 2, no. 1 (2022): 44–55. http://dx.doi.org/10.3390/dna2010004.

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Cell lines are a widely used pre-clinical models for biomedical research. The accessibility and the relative simplicity of facilities necessary for the use of cell lines, along with the large number of potential applications, encourage many researchers to choose this model. However, the access to cell lines from a non-confident source or through the interlaboratory exchange results in uncontrollable cell lines of uncertain quality. Furthermore, the possibility of using cell lines as an endless resource through multiple passages can contribute to this uncontrolled scenario, the main consequence
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Meindl, Bernhard, and Matthias Templ. "Feedback-Based Integration of the Whole Process of Data Anonymization in a Graphical Interface." Algorithms 12, no. 9 (2019): 191. http://dx.doi.org/10.3390/a12090191.

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The interactive, web-based point-and-click application presented in this article, allows anonymizing data without any knowledge in a programming language. Anonymization in data mining, but creating safe, anonymized data is by no means a trivial task. Both the methodological issues as well as know-how from subject matter specialists should be taken into account when anonymizing data. Even though specialized software such as sdcMicro exists, it is often difficult for nonexperts in a particular software and without programming skills to actually anonymize datasets without an appropriate app. The
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Stallone, Giovanni, and Giuseppe Grandaliano. "To discard or not to discard: transplantation and the art of scoring." Clinical Kidney Journal 12, no. 4 (2019): 564–68. http://dx.doi.org/10.1093/ckj/sfz032.

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Abstract The growing gap between inadequate supply and constantly high demand for kidney transplantation observed in the last two decades led to exploring the possibility of using organs from older donors with an increasing number of comorbidities. The main issue in this scenario is to identify transplantable organs and to allocate them to the most suitable recipients. A great number of clinical investigations proposed several acceptance/allocation criteria to reduce the discard rate of these kidneys and to improve their outcome, including histological features at the time of transplant. Despi
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Rendina-Ruedy, Elizabeth, Kelsey D. Hembree, Angela Sasaki, et al. "A Comparative Study of the Metabolic and Skeletal Response of C57BL/6J and C57BL/6N Mice in a Diet-Induced Model of Type 2 Diabetes." Journal of Nutrition and Metabolism 2015 (2015): 1–13. http://dx.doi.org/10.1155/2015/758080.

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Type 2 diabetes mellitus (T2DM) represents a complex clinical scenario of altered energy metabolism and increased fracture incidence. The C57BL/6 mouse model of diet-induced obesity has been used to study the mechanisms by which altered glucose homeostasis affects bone mass and quality, but genetic variations in substrains of C57BL/6 may have confounded data interpretation. This study investigated the long-term metabolic and skeletal consequences of two commonly used C57BL/6 substrains to a high fat (HF) diet. Male C57BL/6J, C57BL/6N, and the negative control strain, C3H/HeJ, mice were fed a c
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