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1

Faúndes, A. "Reproductive tract infections." International Journal of Gynecology & Obstetrics 46, no. 2 (August 1994): 181–87. http://dx.doi.org/10.1016/0020-7292(94)90233-x.

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PRIYADARSHINI, N. HEMA, HARITHA KODALI, and V. K. RAVINDRA KUMAR. "Reproductive Tract Infections Among Currently Married Females in Andhra Pradesh." International Journal of Scientific Research 3, no. 8 (June 1, 2012): 442–45. http://dx.doi.org/10.15373/22778179/august2014/136.

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Dr. K. JOTHY, Dr K. JOTHY. "Socio-Economic and Demographic Determinants of Reproductive Tract Infections (RTIs)." International Journal of Scientific Research 1, no. 1 (June 1, 2012): 87–89. http://dx.doi.org/10.15373/22778179/jun2012/31.

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Lu, Kristina G., and Peter R. Morresey. "Reproductive Tract Infections in Horses." Veterinary Clinics of North America: Equine Practice 22, no. 2 (August 2006): 519–52. http://dx.doi.org/10.1016/j.cveq.2006.03.010.

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5

Nguyen Tien, Nhut, and Huong Le Lam. "LOWER GENITAL TRACT INFECTIONS OF REPRODUCTIVE AGE WOMEN AT HUE UNIVERSITY HOSPITAL." Volume 8 Issue 5 8, no. 5 (October 2018): 102–7. http://dx.doi.org/10.34071/jmp.2018.5.15.

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Introduction: Lower genital tract infections is one of the most common deseases among women in reproductive age and affects the quality of their lives. Objective: To assess the status of lower genital tract infections in reproductive age women and some factors related to vaginosis. Subjects and methods: Crosssectional study of 130 coming for examination at Hue University Hospital from August 2016 to December 2016. Results: The incidence of lower genital infections was 72.3%, with: vaginitis was 34%, vaginitis was 25.5%, vaginitis and cervical was 40.5%. Fungal infection is 20.2%, Gardnerella vaginalis infection is 33%, Parasitic infection is 0%. There is a signification relation between hygiene habits, inflammatory history and numbers of pregnancies with the rates of lower genital infections. There is not a signification relation between history of used contraceptive with lower genital infections. Conclusion: Lower genital tract infections are high percentage among women in reproductive age. There is a signification relation between hygiene habits, inflammatory history and numbers of pregnancies with the rates of lower genital infections. Key words: Women, reproductive age, lower genital tract infections
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6

Althaus, Frances A. "Reproductive Tract Infections and Women's Health." International Family Planning Perspectives 17, no. 4 (December 1991): 145. http://dx.doi.org/10.2307/2133231.

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McClelland, Scott. "PL02.2 Reproductive tract infections in women." Sexually Transmitted Infections 91, Suppl 2 (September 2015): A2.2—A2. http://dx.doi.org/10.1136/sextrans-2015-052270.6.

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Anderson, Deborah J. "Male reproductive tract immune capacity and genital tract infections." Journal of Reproductive Immunology 34, no. 1 (August 1997): 13. http://dx.doi.org/10.1016/s0165-0378(97)90377-6.

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9

Gawande, Kanchan B., Abhay S. Srivastava, and Purushottam Kumar. "Reproductive tract infection and health seeking behaviour: a cross sectional community based study." International Journal Of Community Medicine And Public Health 5, no. 4 (March 23, 2018): 1524. http://dx.doi.org/10.18203/2394-6040.ijcmph20181229.

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Background: Women in India have multitude of health problem, which ultimately affect the economic output. The health of Indian women is intrinsically linked to their status in society. There is significant gap in understanding the reproductive tract infections as well as consequence for women lives. The objective of the study was to study the prevalence of reproductive tract infections and sociodemographic factors responsible among ever married women.Methods: Community based cross sectional study was carried out in the rural area near Mumbai city. List of villages in the study area was obtained from primary health centre (PHC). The prevalence of reproductive tract infections among ever married women was 20.7%. At 95% confidence level and 5% allowable error sample size is 262 (n=4*p*q/l2). So the sample size required to document RTI was 265 ever married women.Results: Prevalence of reproductive tract infections was 143(53.96%). Most common morbidity found was vaginal discharge 59 (22.26%). There was a significant difference between the proportions of study subjects with reproductive tract infection with respect to their educational status & occupation.Conclusions: There was high prevalence of reproductive tract infection among study subjects with only 13.74% visited a qualified medical practitioner for their complaints.
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Whittaker, Maxine. "Negotiating Care: Reproductive Tract Infections in Vietnam." Women & Health 35, no. 4 (July 9, 2002): 43–57. http://dx.doi.org/10.1300/j013v35n04_04.

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11

Cook, Susan W., Hunter A. Hammill, and Richard A. Hull. "Virulence Factors ofEscherichia coliIsolated From Female Reproductive Tract Infections and Neonatal Sepsis." Infectious Diseases in Obstetrics and Gynecology 9, no. 4 (2001): 203–7. http://dx.doi.org/10.1155/s1064744901000333.

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Objective:The presence of enterobacteria such asEscherichia coliin the vagina of normal women is not synonymous with infection. However, vaginalE. colimay also cause symptomatic infections. We examined bacterial virulenceproperties that may promote symptomatic female reproductive tract infections (RTI) and neonatal sepsis.Methods:E. coliisolated as the causative agent from cases of vaginitis (n = 50), tubo-ovarian abscess (n = 45) and neonatal sepsis (n = 45) was examined for selected phenotypic and genetic virulence properties. Results were compared with the frequency of the same properties among fecalE. colinot associated with disease.Results:A significantly greater proportion of infectionE. coliexhibited D-mannose resistant hemagglutination compared with fecalE. coli(p< 0.01). This adherence phenotype was associated with the presence of P fimbriae (pap) genes which were also significantly more prevalent among isolates from all three infection sites (p< 0.01). The majority ofpap+isolates contained thepapG3allele (Class II) regardless of infection type. Increased frequency of Type 1C genes among vaginitis and abscess isolates was also noted. No significant differences in frequency of other bacterial adherence genes, fim, sfa, uca (gaf) or dra were observed. E. coli associated with vaginitis was significantly more likely to be hemolytic ( HIY+) than were fecal isolates (p< 0.05). The HIY+phenotype was also more prevalent among tubo-ovarian abscess and neonatal sepsis isolates (p< 0.08).Conclusions:E. coliisolated from female RTI and neonatal sepses possess unique properties that may enhance their virulence. These properties are similar to those associated with otherE. coliextra-intestinal infections, indicating that strategies such as vaccination or bacterial interference that may be developed against urinary tract infections (UTI) and otherE. coliextra-intestinal infections may also prevent selected female RTI.
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Maharlouei, Najmeh, Esmat Barooti, Farkhondeh Sharif, Hamed Hosseini, and Kamran B. Lankarani. "Prevalence and risk factors of reproductive tract infections among a defined population of Iranian women." Sexual Health 10, no. 4 (2013): 311. http://dx.doi.org/10.1071/sh12193.

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Background Reproductive tract infections are among the most prevalent gynaecological health concerns. The present study aimed to determine the prevalence and risk factors of reproductive tract infections among a defined population of Iranian women. Methods: A cross-sectional study was performed in Shiraz, Southern Iran, from 2007 to 2009. The study subjects were 28 484 vulnerable household women who were covered by the Imam Khomeini Relief Foundation insurance scheme. All the participants underwent vaginal speculum examinations and swab sampling. Vaginal discharge was collected for Gram staining, potassium hydroxide mount, wet mount and in a transport medium for culture and sensitivity testing. The frequency of reproductive tract infections and their risk factors were determined. Results: The mean age of the 28 484 women who participated in the study was 48.7 ± 10.1 (range: 13–104) years. According to the results, 13 472 (47.3%) subjects had reproductive tract infections. Moreover, vulvovaginal candidiasis was the most common infection in our population, accounting for 4718 subjects (16.6%), followed by trichomoniasis (11.2%) and bacterial vaginosis (10.6%). Furthermore, the number of pregnancies, being married and low educational levels (illiterate and under diploma level) were the risk factors for these infections, whereas the use of oral contraceptives and being employed were the protective factors. Conclusion: Almost half of the vulnerable Iranian women suffer from reproductive tract infections, with candidiasis and trichomoniasis being the most prevalent types. Based on the high prevalence of these infections, appropriate and precise screening programs should be taken into consideration for this specific population.
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Nayab, Durr-e. "Reproductive Tract Infections among Women in Pakistan: An Urban Case Study." Pakistan Development Review 44, no. 2 (June 1, 2005): 131–58. http://dx.doi.org/10.30541/v44i2pp.131-158.

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Reproductive tract infections (RTIs) among women—despite being common and having grave consequences—are not given much attention by policy-makers and health planners. The asymptomatic nature of most infections makes their detection and diagnosis difficult, making laboratory testing the most accurate method of bio-medical diagnosis. The present paper assesses the magnitude and nature of infections as diagnosed through laboratory testing and looks into the variation in magnitude and the nature of RTIs among women with different socio-economic and demographic characteristics. The aetiological rate of infection among women is found to be 24 percent, with the majority of these women testing positive for endogenous infections. Factors significantly increasing the likelihood of having an infection include intrauterine device use or getting a tubectomy, short inter-pregnancy intervals, and lower economic status of women.
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14

Gupta, Amit Kumar. "Control of Sexually Transmitted Infections, Reproductive Tract Infections, and HIV/AIDS in India: Current Status and the Way Forward." Epidemiology International 02, no. 03 (December 7, 2017): 19–29. http://dx.doi.org/10.24321/2455.7048.201715.

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15

Ahmed, Mohsin U., Tanjina Mirza, Parveen A. Khanum, Mehrab A. Khan, Shameem Ahmed, and Mobarak H. Khan. "Management of Reproductive Tract Infections in Rural Bangladesh." International Journal of STD & AIDS 10, no. 4 (April 1999): 263–67. http://dx.doi.org/10.1258/0956462991913916.

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16

Mulla, SummaiyaA, JK Kosambiya, VikasK Desai, and NimishaD Shethwala. "Sexually transmitted infections and reproductive tract infections in female sex workers." Indian Journal of Pathology and Microbiology 52, no. 2 (2009): 198. http://dx.doi.org/10.4103/0377-4929.48916.

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17

Bhalla, P., D. Rawat, R. Tripathi, R. Kaur, K. Sardana, and S. Bhattar. "Asymptomatic reproductive tract infections/sexually transmitted infections among HIV positive women." Indian Journal of Medical Microbiology 33, no. 3 (2015): 410. http://dx.doi.org/10.4103/0255-0857.158568.

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18

Ganguly, Subha, and Sunit Kumar Mukhopadhayay. "A Comprehensive Review on Reproductive Tract Infections Causing Fetal Deaths and Abortions in Large Ruminants." Asian Pacific Journal of Health Sciences, Supplimentary 2014 (2014): 54–57. http://dx.doi.org/10.21276/apjhs.2014.1.1s.12.

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19

Sallam, S. A., A. A. Mahfouz, N. I. Dabbous, M. El Barrawy, and M. M. El Said. "Reproductive tract infections among married women in Upper Egypt." Eastern Mediterranean Health Journal 7, no. 1-2 (March 15, 2001): 139–46. http://dx.doi.org/10.26719/2001.7.1-2.139.

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In a house-to-house survey using cluster sampling, 1344 married women from urban and rural areas of Upper Egypt [Minia, Assiut and Sohag] were interviewed and examined to study the magnitude and determinants of reproductive tract infections. Overall prevalence was found to be 52.8%, with the most prevalent forms being Candida albicans [28.0%], Trichomonas vaginalis [8.7%], Aspergillus species [7.4%], streptococci [4.6%] and Chlamydia trachomatis [4.2%]. Multivariate analysis identified certain groups of women at high risk of developing reproductive tract infections [those currently using an intrauterine device, those who regularly practised internal vaginal washing]. Discriminant analysis showed that symptoms were of low discriminating value. There is a great need to increase community and women’s understanding of reproductive tract infections.
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20

Rosales, Eduardo Barahona, and Burim N. Ametaj. "Reproductive Tract Infections in Dairy Cows: Can Probiotics Curb Down the Incidence Rate?" Dairy 2, no. 1 (January 18, 2021): 40–64. http://dx.doi.org/10.3390/dairy2010004.

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Postpartum uterine diseases are common in dairy cows and are a great concern for the dairy industry as they are associated with various consequences, including lower fertility, lower milk yield, and an overall negative impact on the host health. An infected uterus is a source of bacterial compounds and cytokines that spill into the systemic circulation, spreading inflammation to other organs. In this review article, we discuss a short overview of the anatomy of the reproductive tract of dairy cows and several infectious diseases of the uterus including metritis, endometritis, and pyometra. Additionally, we discuss the microbiome of the reproductive tract in health and during uterine diseases. As well, diagnostic criteria for metritis and endometritis and contributing factors for increased susceptibility to metritis infection are important topics of this review. To better understand how the uterus and reproductive tract respond to bacterial pathogens, a section of this review is dedicated to immunity of the reproductive tract. Both the innate and adaptive immunity systems are also discussed. We conclude the review with a factual discussion about the current treatments of uterine diseases and the new developments in the area of application of probiotics for uterine health. Mechanisms of actions of probiotics are discussed in detail and also some applications to prevent uterine infections in dairy cows are discussed.
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21

Salmanov, Aidyn G., Lidiya V. Suslikova, Svitlana A. Pandei, Victor O. Rud, Igor V. Kokhanov, Victoria Ye Butska, and Alexander G. Tymchenko. "HEALTHCARE ASSOCIATED DEEP PELVIC TISSUE INFECTION AND OTHER INFECTIONS OF THE FEMALE REPRODUCTIVE TRACT IN UKRAINE." Wiadomości Lekarskie 74, no. 3 (2021): 406–12. http://dx.doi.org/10.36740/wlek202103105.

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The aim: To obtain the first estimates of the current prevalence of healthcare-associated deep pelvic tissue infection and other infections of the female reproductive tract (vagina, ovaries, uterus) including chorioamnionitis, and antimicrobial resistance of causing pathogens in Ukraine. Materials and methods: We performed a retrospective multicenter cohort study was based on surveillance data. The study population included 3,053 women’s who underwent gynecological surgery or other procedures from 2017 to 2019 in 7 women hospitals in Ukraine. Definitions of healthcare-associated reproductive tract infection were used from the CDC/ NHSN. Results: The prevalence of healthcare-associated deep pelvic tissue infection and other infections of the female reproductive tract was 26.3%. Incidence of infection was: 13.3% Pelvic abscess or cellulitis, 14.6% Adnexa utery, 9.5% Salpingitis, 7.1% Oophoritis, 12.2% Parametritis, 4.6% Chorioamnionitis, and 38.8% Bacterial Vaginitis. The predominant pathogens were: Escherichia coli (25.6%), Enterobacter spp. (11.4%), Klebsiella pneumoniae (10.6%), Staphylococcus aureus (8.5%), Enterococcus faecalis (7.2%) and Pseudomonas aeruginosa (7.1%). Methicillin-resistance was observed in 14.3% of S. aureus (MRSA). The overall proportion of extended spectrum beta-lactamases (ESBL) production among Enterobacteriaceae was 20.8%. The prevalence of ESBL production among E. coli isolates was 24.7% and among K. pneumoniae 11.9%. Resistance to thirdgeneration cephalosporins was observed in 12.8% E.coli and 9.2% K. pneumoniae isolates. Carbapenem resistance was identified in 8.5% of P.aeruginosa isolates. Conclusions: Healthcare associated deep pelvic tissue infection and other infections of the female reproductive tract in Ukraine is a common occurrence and many cases are caused by pathogens that are resistant to antibiotics.
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Ramli, Risnawati. "Prevention and Treatment of Reproductive Tract Infection." Journal La Medihealtico 1, no. 1 (January 29, 2020): 8–12. http://dx.doi.org/10.37899/journallamedihealtico.v1i1.14.

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Reproductive Tract Infections (ISR) occur because of the process of entering and breeding the germs that cause infections into the female reproductive tract. Caring for sexual organs is often not done as often as caring for other organs. Though sexual organs need extra attention. In these sexual organs, the resulting sweat is quite excessive. So that the sexual organs become moist. prevention that can be done to prevent the occurrence of sexually transmitted diseases that is with care and maintain the cleanliness of the reproductive organs. Treatments that can be done are consuming healthy and nutritious eating, avoid using tight pants, check with your doctor if you experience vaginal discharge for a very long time, make it a habit to cleanse the genitals after sexual intercourse, do not use pantyliner, avoid having sexual intercourse with multiple partners. Washing the genitals every day, changing clothes frequently, at least twice a day in the bath, during menstruation, use soft pads, always wash hands before touching the genitals, avoid using other people's towels or washcloths and shave a portion of pubic hair to prevent bacterial growth
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Salvatore, Stefano, Silvia Salvatore, Elena Cattoni, Gabriele Siesto, Maurizio Serati, Paola Sorice, and Marco Torella. "Urinary tract infections in women." European Journal of Obstetrics & Gynecology and Reproductive Biology 156, no. 2 (June 2011): 131–36. http://dx.doi.org/10.1016/j.ejogrb.2011.01.028.

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Mayank, S., R. Bahl, and N. Bhandari. "Reproductive tract infections in pregnant women in Delhi, India." International Journal of Gynecology & Obstetrics 75, no. 1 (October 2001): 81–82. http://dx.doi.org/10.1016/s0020-7292(01)00444-1.

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Goel, V., Y. Mala, R. Tripathi, and P. Bhalla. "O347 Screening HIV seropositive women for reproductive tract infections." International Journal of Gynecology & Obstetrics 107 (October 2009): S191. http://dx.doi.org/10.1016/s0020-7292(09)60719-0.

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El Said, M. M., S. A. Sallam, A. A. Mahfouz, N. I. Dabbous, M. El-Barrawy, A. El-Ghamry, and A. Malatawy. "Reproductive tract infections among married women in upper Egypt." International Journal of Gynecology & Obstetrics 70 (2000): D125—D126. http://dx.doi.org/10.1016/s0020-7292(00)84594-4.

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27

FRENCH, JANICE I., JAMES A. MCGREGOR, DEBORAH DRAPER, RUTH PARKER, and JOHN MCFEE. "Gestational Bleeding, Bacterial Vaginosis, and Common Reproductive Tract Infections." Obstetrics & Gynecology 93, no. 5, Part 1 (May 1999): 715–24. http://dx.doi.org/10.1097/00006250-199905000-00017.

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28

Bohara, MS, AB Joshi, B. Lekhak, and G. Gurung. "Reproductive tract infections among women attending gynaecology outpatient department." International Journal of Infection and Microbiology 1, no. 1 (October 9, 2012): 29–33. http://dx.doi.org/10.3126/ijim.v1i1.6940.

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BACKGROUND: Women often suffer silently with reproductive tract infections (RTIs) and sexually active young women are particularly susceptible to sexually transmitted Infections (STIs). The study aimed to know the prevalence of reproductive tract infections among married women attending Gynecological Outpatients Department of Tribhuvan University Teaching Hospital (TUTH), Kathmandu, Nepal. MATERIALS AND METHODS: A hospital based crosssectional design was used to investigate RTIs among women attending outpatients department of Gynae and Obstetrics, TUTH from July to November, 2006. A total of 208 samples from 104 women were examined microscopically and culture using standard microbial technique to investigate etiological agents of RTIs. Study samples were selected and examined on the basis of either having discharge or complaints of lower abdominal pain. RESULTS: A total of 208 samples collected from 104 patients were examined and 26% samples were positive for different causative agents of RTIs. Thirty percent of women reported having symptoms related to RTIs and was common in young married women. Nineteen percent had STIs. Thirteen percent had trichomonasis and 7% had gonorrhoea identified in Gram stained smears and cultures. Many women had endogenous RTIs. Bacterial vaginosis was diagnosed in 15% and vaginal candidiasis in 25% of women. CONCLUSIONS: Young married women have a high prevalence of RTIs. Education and outreach programs are needed to reduce embarrassment and lack of knowledge related to RTIs. The low socio?economic status of women appears to have influence on high rate of infections. DOI: http://dx.doi.org/10.3126/ijim.v1i1.6940Int J Infect Microbiol 2012;1(1):29-33
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Lien, Phan, Christopher Elias, Nguyen Loi, Bui Chi, Nguyen Hua Phuc, and Michelle Gardner. "The Prevalence of Reproductive Tract Infections in Hue, Vietnam." Studies in Family Planning 33, no. 3 (September 2002): 217–26. http://dx.doi.org/10.1111/j.1728-4465.2002.00217.x.

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30

Gupta, Anmol K., Anita Thakur, Tripti Chauhan, and Nidhi Chauhan. "A study to determine socio demographic corelates of reproductive tract infection amongst women of reproductive age group." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 9, no. 8 (July 23, 2020): 3463. http://dx.doi.org/10.18203/2320-1770.ijrcog20203342.

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Background: Reproductive tract infection (RTI) is a public health problem, especially in developing country like India. The associated odium with this reproductive morbidity is often a stumbling block in seeking health care. The aim was to study the prevalence of RTI symptoms and its socio-demographic corelates.Methods: A cross-sectional study was undertaken in the rural field practice area of department of community medicine, Indira Gandhi Medical College, Shimla, Himachal Pradesh, India, from July 2018 to September 2018. Total sample size calculated was 410. Random sampling was used to select eligible couple to whom a predesigned, pretested, semi-structured and anonymous interview schedule was administered after taking consent.Results: The prevalence of self-reported reproductive tract infections was found to be 41.2%. The prevalence was more in lower socio-economic classes, and it was statistically significant. Other socio-demographic corelates (age, education, occupation) did not showed any significant association.Conclusions: The reproductive tract infections prevalence is found to be considerably high in the women of reproductive age group. The frequency was higher among multigravida women and those using cloth during menstrual periods. RTIs are usually spurned by women and even the health care providers, so there is a need to give due consideration to this aspect of reproductive health.
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Horne, Andrew W., Sarah J. Stock, and Anne E. King. "Innate immunity and disorders of the female reproductive tract." REPRODUCTION 135, no. 6 (June 2008): 739–49. http://dx.doi.org/10.1530/rep-07-0564.

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Sexually transmitted infections, and their associated sequelae, such as tubal infertility, ectopic pregnancy and preterm labour, are a major worldwide health problem. Chlamydia trachomatis infection is thought to be the leading global cause of tubal infertility and tubal ectopic pregnancy. Preterm birth occurs in around 10% of all deliveries, and nearly 30% of preterm deliveries are associated with intrauterine infection. The mucosal innate immune system of the female reproductive tract has evolved to eliminate such sexually transmitted pathogens whilst maintaining its ability to accommodate specialized physiological functions that include menstruation, fertilization, implantation, pregnancy and parturition. The aim of this review was to describe the role and distribution of key mediators of the innate immune system, the natural antimicrobial peptides (secretory leukocyte protease inhibitor, elafin and the defensins) and the pattern recognition toll-like receptors in the normal female reproductive tract and in the context of these pathological processes.
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Letyaeva, O. I., and O. R. Ziganshin. "Pathogenic treatment of the inflammatory diseases of the urogenital tract in women of reproductive age." Russian Journal of Woman and Child Health 4, no. 1 (2021): 59–64. http://dx.doi.org/10.32364/2618-8430-2021-4-1-59-64.

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This paper discusses one of the important gynecological issues, inflammatory diseases of the urogenital tract caused by opportunistic microbes. The treatment and long-term control over these conditions are challenging and depend on their occurrence and high risk of complications. Impaired local anti-infectious protection is one of the risk factors of chronic inflammation. Since the disease may recur even after successful treatment, domestic and foreign authors increasingly focus on immunotherapy as a part of complex strategy and isolated entity. Local immunotherapy may prevent recurrences and activate host defense. This paper describes the management of two women with mixed infections. The first woman with chronic recurrent inflammation (cervicitis caused by U. urealyticum, vulvovaginal candidiasis, and aerobic vaginitis) in whom prior etiological therapy was ineffective received immunotherapy which resulted in long-term remission. The second woman with coexistent papillomavirus infection (genital warts) and bacterial vaginosis received immunotherapy and topical etiological treatment. As a result, clinical symptoms, the size and number of genital warts reduced which greatly facilitated their chemical destruction. KEYWORDS: genital tract, urogenital infections, papillomavirus infection, bacterial vaginosis, local immunity, biofilms. FOR CITATION: Letyaeva O.I., Ziganshin O.R. Pathogenic treatment of the inflammatory diseases of the urogenital tract in women of reproductive age. Russian Journal of Woman and Child Health. 2021;4(1):59–64. DOI: 10.32364/2618-8430-2021-4-1-59-64.
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Chumduri, Cindrilla, and Margherita Y. Turco. "Organoids of the female reproductive tract." Journal of Molecular Medicine 99, no. 4 (February 13, 2021): 531–53. http://dx.doi.org/10.1007/s00109-020-02028-0.

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AbstractHealthy functioning of the female reproductive tract (FRT) depends on balanced and dynamic regulation by hormones during the menstrual cycle, pregnancy and childbirth. The mucosal epithelial lining of different regions of the FRT—ovaries, fallopian tubes, uterus, cervix and vagina—facilitates the selective transport of gametes and successful transfer of the zygote to the uterus where it implants and pregnancy takes place. It also prevents pathogen entry. Recent developments in three-dimensional (3D) organoid systems from the FRT now provide crucial experimental models that recapitulate the cellular heterogeneity and physiological, anatomical and functional properties of the organ in vitro. In this review, we summarise the state of the art on organoids generated from different regions of the FRT. We discuss the potential applications of these powerful in vitro models to study normal physiology, fertility, infections, diseases, drug discovery and personalised medicine.
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McGowin, Chris L., Rae Ann Spagnuolo, and Richard B. Pyles. "Mycoplasma genitalium Rapidly Disseminates to the Upper Reproductive Tracts and Knees of Female Mice following Vaginal Inoculation." Infection and Immunity 78, no. 2 (December 7, 2009): 726–36. http://dx.doi.org/10.1128/iai.00840-09.

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ABSTRACT Mycoplasma genitalium is an emerging sexually transmitted infection and in women is associated with notable reproductive tract syndromes such as cervicitis, pelvic inflammatory disease, and infertility. Investigations into the causal relationships of M. genitalium infections and clinical disease have been hindered largely by the lack of a well-established small-animal model of genital tract infection. To establish a murine model, female Swiss Webster mice were conditioned with either progesterone or estradiol and then inoculated intravaginally with M. genitalium type strain G37 or a contemporary Danish strain, M2300. Persistent lower tract infection was observed at up to 77 days postinoculation (d.p.i.). Upper reproductive tract colonization was observed as early as 3 d.p.i., with long-term infection observed in estradiol-treated (65%) and progesterone-treated (18%) animals. In the upper tract, more than 90% of M. genitalium PCR-positive samples were from the uterus and oviducts. Ultimately, gross hydrosalpinx was observed 21 days to 10 weeks p.i. in approximately 60% of infected animals, suggesting the presence of tubal occlusion. In addition, dissemination of M. genitalium to the knee tissues was observed as early as 7 d.p.i., with persistent infection detected at up to 28 d.p.i. Mice infected with M. genitalium also developed specific antibodies to the major antigenic outer membrane protein MgPa, elongation factor Tu, pyruvate dehydrogenase E1α, and DnaK (Hsp70), indicating persistent infection despite robust humoral responses to infection. These findings provide strong experimental evidence that M. genitalium can establish long-term infection of reproductive tract and joint tissues, with preliminary evidence of pathological reproductive tract outcomes.
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Kaushic, Charu, Andrew D. Murdin, Brian J. Underdown, and Charles R. Wira. "Chlamydia trachomatis Infection in the Female Reproductive Tract of the Rat: Influence of Progesterone on Infectivity and Immune Response." Infection and Immunity 66, no. 3 (March 1, 1998): 893–98. http://dx.doi.org/10.1128/iai.66.3.893-898.1998.

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ABSTRACT As the most common cause of sexually transmitted disease in women, chlamydial infections can lead to pelvic inflammatory disease, infertility, and ectopic pregnancy. To better understand the role played by sex hormones in modulating the immune response of the genital tract to microbial infections, we have developed a rat model to studyChlamydia trachomatis infection. Inbred female Lewis rats were primed with progesterone and inoculated by intrauterine instillation of C. trachomatis (mouse pneumonitis strain MoPn) into each uterine horn. When infected animals were examined for the presence of chlamydial antigens 14 days postinfection, both the uterus and vagina were found to be positive compared to those of saline-treated animals, which did not show specific staining. The involvement of local and systemic immune systems following chlamydial infection was determined by analyzing major histocompatibility complex (MHC) class II expression in the reproductive tract and lymphocyte proliferation in response to mitogenic and chlamydia-specific stimulation of cells from the spleen and lymph nodes (LN) draining the reproductive tract. Enhanced proliferation was observed in LN following mitogenic but not antigenic (MOMP [major outer membrane protein]) stimulation. In contrast, spleen cell proliferation was lower in chlamydia-infected rats than in saline-treated controls. MHC class II expression, an indicator of inflammatory responses, was upregulated in the uterus, on glandular epithelial cells, and adjacent to glands in response to chlamydial infection. In other experiments, when rats were infected at estrus and diestrus without prior progesterone priming, chlamydial inclusions were not detected in either the uterus or vagina. However, enhanced lymphocyte proliferation was observed in response to mitogenic and MOMP stimulation in the reproductive tract-draining LN from estrous and diestrous animals. These findings indicate that under appropriate endocrine conditions, the rat uterus is susceptible to C. trachomatisinfection and that immune responses to this pathogen can be detected locally and systemically. Further, they suggest that clearance of the infection from the reproductive tract involves immune cells from the LN draining the reproductive tract.
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Callan, Torrington, Stephen Woodcock, and Wilhelmina May Huston. "Ascension of Chlamydia is moderated by uterine peristalsis and the neutrophil response to infection." PLOS Computational Biology 17, no. 9 (September 7, 2021): e1009365. http://dx.doi.org/10.1371/journal.pcbi.1009365.

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Chlamydia trachomatis is a common sexually transmitted infection that is associated with a range of serious reproductive tract sequelae including in women Pelvic Inflammatory Disease (PID), tubal factor infertility, and ectopic pregnancy. Ascension of the pathogen beyond the cervix and into the upper reproductive tract is thought to be necessary for these pathologies. However, Chlamydia trachomatis does not encode a mechanism for movement on its genome, and so the processes that facilitate ascension have not been elucidated. Here, we evaluate the factors that may influence chlamydial ascension in women. We constructed a mathematical model based on a set of stochastic dynamics to elucidate the moderating factors that might influence ascension of infections in the first month of an infection. In the simulations conducted from the stochastic model, 36% of infections ascended, but only 9% had more than 1000 bacteria ascend. The results of the simulations indicated that infectious load and the peristaltic contractions moderate ascension and are inter-related in impact. Smaller initial loads were much more likely to ascend. Ascension was found to be dependent on the neutrophil response. Overall, our results indicate that infectious load, menstrual cycle timing, and the neutrophil response are critical factors in chlamydial ascension in women.
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Balushkina, A. A., N. E. Kan, and V. L. Tyutyunnik. "Therapy of urinary tract infections in gynecological practice." Medical Council, no. 7 (April 5, 2019): 87–92. http://dx.doi.org/10.21518/2079-701x-2019-7-87-92.

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The urinary tract infection continue to exert significant impact on millions of patients worldwide, most of whom are otherwise healthy reproductive women. Antibiotic therapy for acute cystitis does not prevent recurrences, which plague up to one fourth of women after an initial urinary tract infection. Rising antimicrobial resistance among uropathogenic bacteria further complicates therapeutic decisions, necessitating new approaches based on fundamental investigation.
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Ishaq Bhatti, Lubna, and Fariyal F. Fikree. "Health-seeking behavior of Karachi women with reproductive tract infections." Social Science & Medicine 54, no. 1 (January 2002): 105–17. http://dx.doi.org/10.1016/s0277-9536(01)00012-0.

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39

Nguyễn, M[ytilde] Hu'o'ng, Tine Gammeltoft, Sarah Vigh Christoffersen, Thu Thuỷ Trần, and Vibeke Rasch. "Reproductive Tract Infections in Northern Vietnam: Health Providers' Diagnostic Dilemmas." Women & Health 49, no. 2-3 (June 9, 2009): 229–45. http://dx.doi.org/10.1080/03630240902963630.

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Guerreiro, D., M. A. M. Gigante, and L. C. Teles. "Sexually transmitted diseases and reproductive tract infections among contraceptive users." International Journal of Gynecology & Obstetrics 63 (December 1998): S167—S173. http://dx.doi.org/10.1016/s0020-7292(98)00201-x.

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Bergsjø, Per. "Book Review. Investigating Reproductive Tract Infections and other Gynaecological Disorders." Acta Obstetricia et Gynecologica Scandinavica 83, no. 12 (November 16, 2004): 1231. http://dx.doi.org/10.1111/j.0001-6349.2004.00515.x.

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42

SINGH, VEENA, MADAN M. GUPTA, L. SATYANARAYANA, A. PARASHARI, ASHOK SEHGAL, D. CHATTOPADHYA, and P. SODHANI. "Association Between Reproductive Tract Infections and Cervical Inflammatory Epithelial Changes." Sexually Transmitted Diseases 22, no. 1 (January 1995): 25–30. http://dx.doi.org/10.1097/00007435-199501000-00005.

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Durai, Vanitha, Suresh Varadharajan, and AnithaR Muthuthandavan. "Reproductive tract infections in rural India – A population-based study." Journal of Family Medicine and Primary Care 8, no. 11 (2019): 3578. http://dx.doi.org/10.4103/jfmpc.jfmpc_703_19.

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Diadhiou, Mohamed, Awa Ba Diallo, Mamadou Saidou Barry, Serge Covi Alavo, Ibrahima Mall, Omar Gassama, Mame Diarra Ndiaye Guèye, et al. "Prevalence and Risk Factors of Lower Reproductive Tract Infections in Symptomatic Women in Dakar, Senegal." Infectious Diseases: Research and Treatment 12 (January 2019): 117863371985182. http://dx.doi.org/10.1177/1178633719851825.

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Background: Lower reproductive tract infections in women are important causes of morbidity but can also lead to complications and sequelae. This study aimed to establish the prevalence and risk factors of lower genital tract infections among women of reproductive age in Dakar (Senegal). Methods: This was a prospective study conducted in 6 maternity hospitals from July to November 2015. Participants ranged in age from 18 to 49 years and presented at health facilities with signs and symptoms of genital infection. Consenting individuals who met the inclusion criteria were recruited for the study. Results: During the reporting period, 276 patients were enrolled. According to the laboratory results, the prevalence of any genital infection was 69.6% (192 of 276). The most common vaginal infections were bacterial vaginosis (39.5%) and vaginal candidiasis (29%), with the third most common cause, trichomoniasis, trailing behind in terms of prevalence (2.5%). Among the microorganisms responsible for cervical infections, Ureaplasma urealyticum was the most frequent (27.5%), followed by Mycoplasma hominis (14.5%), Chlamydia trachomatis (4.7%), and Neisseria gonorrhoeae (1.1%). Multivariate analysis showed that young women and women with low levels of education were at increased risk for vaginal/cervical infections. Conclusions: This study revealed a high prevalence of bacterial vaginosis and vaginal candidiasis and suggests that health care providers should increase awareness and communication to improve vaginal hygiene practices. If infection with Trichomonas vaginalis, C trachomatis or N gonorrhoeae is suspected, we also recommend systematically performing laboratory diagnostic confirmation.
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Palmieri, Chiara, Lyndal Hulse, Sara Pagliarani, Rebecca Larkin, Damien P. Higgins, Kenneth Beagley, and Stephen Johnston. "Chlamydia pecorum Infection in the Male Reproductive System of Koalas (Phascolarctos cinereus)." Veterinary Pathology 56, no. 2 (October 31, 2018): 300–306. http://dx.doi.org/10.1177/0300985818806963.

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Chlamydiosis is the most documented and serious disease of koalas, characterized by ocular, urinary, and reproductive lesions. Since little attention has been paid to the pathological effects of this infection in the male reproductive system, we aimed to determine the incidence and severity of reproductive pathology associated with chlamydial infection in male koalas submitted to koala hospitals in southeast Queensland. The entire reproductive tract from 62 sexually mature male koalas not suitable for rehabilitation was evaluated and 677 tissue samples were collected for histology, immunohistochemistry (IHC), and real-time polymerase chain reaction (qPCR). Lymphoplasmacytic inflammation was observed in 178 of 677 (26.3%) tissue samples from the upper and lower reproductive tract, mainly in the prostatic, penile, and membranous urethra. IHC was positive for the chlamydial antigen in 19 of 451 normal samples (4.2%) and 46 of 178 samples with inflammation (25.8%), located within the cytoplasm of epithelial cells of the epididymis, vas deferens, prostate, bulbourethral glands, and the prostatic membranous and penile urethra. Chlamydia pecorum was detected via qPCR in 319 of 451 normal samples (70.7%) and 159 of 178 samples with inflammation (89.3%), with the highest incidence in the penile urethra, prostate, membranous urethra, and bulbourethral glands. This study suggests that Chlamydia infection in the male reproductive tract is more widespread than originally thought. Furthermore, the male reproductive tract might be a reservoir for persistent chlamydial infections in koalas, with important implications for prophylactic strategies and epidemiology.
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Thomas, Enid Elizabeth, and Jayasree Anandabhavan Kumaran. "Prevalence of genital infections among women in reproductive age group in a rural area in North Kerala." International Journal Of Community Medicine And Public Health 6, no. 7 (June 28, 2019): 2996. http://dx.doi.org/10.18203/2394-6040.ijcmph20192841.

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Background: Genital infections, a major cause of illness among women in reproductive age group, affect their quality of life and social living. Early diagnosis and treatment of STI/RTI is also an important aspect in prevention of HIV transmission. As there are only a handful of studies in Kerala and none in Kannur assessing the prevalence, associated factors of genital infections and health seeking behaviour among women in reproductive age group, this study stands important.Methods: A community based descriptive study was conducted in Kulappuram area of Cheruthazham Panchayat which is the field practice area of Department of Community Medicine, Government Medical College, Kannur, Pariyaram from June, 2017 – July, 2018. A total of 404 women in reproductive a group were studied. A semi-structured, pre-tested questionnaire was used to collect relevant information. Data was analyzed using SPSS-version 19 software.Results: The mean age of the study population was 32.20±10.741years. 52.7% of the study population had genital infection, with 40.6% having symptoms of Reproductive Tract Infections (RTI) and 12.1%, symptoms of Urinary tract Infections (UTI). The presence of these was significantly associated with menstrual disorders, cloth as menstrual pad users, marriage, sexual activity and absence of infertility. Only 39.0% of the women with infections had sought treatment.Conclusions: Although there was high prevalence of genital infections among the study population, treatment seeking behaviour was very low. There is a need for sustained motivation and support to promote women to seek timely medical care than to suffer silently.
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Labuda, Jasmine C., Oanh H. Pham, Claire E. Depew, Kevin D. Fong, Bokyung Lee, Jordan A. Rixon, and Stephen J. McSorley. "Circulating immunity protects the female reproductive tract from Chlamydia infection." Proceedings of the National Academy of Sciences 118, no. 21 (May 17, 2021): e2104407118. http://dx.doi.org/10.1073/pnas.2104407118.

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Anatomical positioning of memory lymphocytes within barrier tissues accelerates secondary immune responses and is thought to be essential for protection at mucosal surfaces. However, it remains unclear whether resident memory in the female reproductive tract (FRT) is required for Chlamydial immunity. Here, we describe efficient generation of tissue-resident memory CD4 T cells and memory lymphocyte clusters within the FRT after vaginal infection with Chlamydia. Despite robust establishment of localized memory lymphocytes within the FRT, naïve mice surgically joined to immune mice, or mice with only circulating immunity following intranasal immunization, were fully capable of resisting Chlamydia infection via the vaginal route. Blocking the rapid mobilization of circulating memory CD4 T cells to the FRT inhibited this protective response. These data demonstrate that secondary protection in the FRT can occur in the complete absence of tissue-resident immune cells. The ability to confer robust protection to barrier tissues via circulating immune memory provides an unexpected opportunity for vaccine development against infections of the FRT.
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Kowalczyk, Joanna, Marcin Śmiałek, Bartłomiej Tykałowski, and Andrzej Koncicki. "Selected issues in local immune system of hen's reproductive tract." Medycyna Weterynaryjna 72, no. 11 (2016): 671–76. http://dx.doi.org/10.21521/mw.5590.

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In terms of its anatomy and functions, the reproductive system of birds is significantly different from the one found in mammals. It consists of only the left ovary and the left oviduct, which is constantly exposed to ascending infections because of its connection with the cloaca. Hence, the proper functioning of humoral and cell-mediated local immune mechanisms in this system is very important for maintaining its physiological functions. The expression of Toll-like receptors and the presence of T and B lymphocytes have been demonstrated in both the ovary and the oviduct of chickens. CD4+ T cell subpopulation is distributed mainly in the lamina propria of the oviduct, whereas in the submucous membrane and muscular layer these cells are found less frequently. CD8+ T lymphocytes are equally distributed in all abovementioned layers of the oviduct wall. IgY+ B cells are distributed among the epithelial cells, and they are closely connected with the glandular tissue of the oviduct, mainly in the infundibulum, magnum, and uterus regions. IgA+ and IgM+ B cells are present in the entire oviduct, but mainly in the glandular tissue of the magnum. IgY+ B cells have not been detected in the ovary, unlike IgM+ B cells, which have been demonstrated in the ovary stroma. In addition to T and B cells, antigen-presenting cells are present in the follicle wall and in the oviduct. During the early stages of reproductive maturation, a decrease in the number of immunocompetent cells is observed in the reproductive system, and the local immnosuppression increases the susceptibility of birds to Salmonella Enteritidis infections. The number of T and B lymphocytes in the mucous membrane of the oviduct decreases with age, which facilitates infections of the reproductive system. Additionally, the local immune mechanisms of the reproductive system in birds involve the transfer of protective IgY, IgA and IgM maternal antibodies to hatching eggs. The local immune mechanisms of the reproductive tract are responsible for preventing infections that disturb the physiological functions of the reproductive system and for protecting eggs from contamination.
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Ramejo, Bushra Begum, Sanober Soomro, Sana Sadaf, Khush Muhammad Sohu, and Mubashir Ahmed Ramejo. "Frequency of common organisms causing vaginal discharge in sexually active women in reproductive age group." Professional Medical Journal 28, no. 01 (January 10, 2021): 86–89. http://dx.doi.org/10.29309/tpmj/2021.28.01.5470.

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Objective: To determine the frequency of organisms causing vaginal discharge. Study Design: Descriptive study. Setting: Department of Gynecology and Obstetrics Unit-II of Kausar Hospital Khairpur Mirs, Sindh. Period: 23rd, October 2019 to 22nd January 2020. Material & Methods: Study population include sexually active females aged 18-45 visiting to the OPD for complain of vaginal discharge. A complete history and examination was done for assessment of the patient for reproductive tract infections. Results: In one year time period 420 females reported to the OPD of the hospital. Out of total 1783 patients, 23.5% patients (n=420) had complaint of vaginal discharge. Out of 420 patients enrolled in the study, 43.8% (n=184) patients were diagnosed having non-infective vaginal discharge. Bacterial vaginosis had the highest prevalence among common reproductive tract infection estimating about 46.1% (n=109) cases. Conclusion: Multiple researches must be conducted on large scale to determine the actual ratio of reproductive tract infections in sexually active females. Furthermore awareness session should be delivered to the rural and urban population. Awareness to women regarding their sexual health and their positive influence on society should be given.
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Panjaitan, Cahaya, Endang Suprihati, Aditya Yudhana, Poedji Hastutiek, Prima Ayu Wibawati, and Muhammad Thohawi Elziyad Purnama. "Acanthochephaliasis in White-lipped Green Pitviper (Trimeresurus insularis)." Jurnal Medik Veteriner 4, no. 1 (April 15, 2021): 155. http://dx.doi.org/10.20473/jmv.vol4.iss1.2021.155-159.

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White-lipped Green Pitviper (Trimeresurus insularis) is one type of snake whose population in nature is still not extinct and has a wide spread starting from the island of Java, Bali, Komodo, Lombok, Padar, Rinca, Romang, Roti, Sumba, Sumbawa, Timor. Population decline can occur if the incidence of disease infections continues to increase, one of the most common infectious diseases is helminthiasis. This study aimed to identify and determine the level of Acathochepala infection in White-lipped Green Pitviper in Banyuwangi Regency. A total of 20 green snakes were examined for Acanthochepala infection. Identification was done when the worm had been stained using carmine. The results showed that 20 positive green snake samples were infected with Acanthochepala in the subcutan, muscle tissue, digestive tract and reproductive tract.
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