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Relevant bibliographies by topics / Rescue / Dissertations / Theses

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Dissertations / Theses on the topic 'Rescue'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Starr, Talcott Copeland. "Rescue Archaeology." Miami University / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=miami1217341314.

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2

Gou, Alsina Gemma. "Molecular mechanisms underlying the role of SynGAP in cognition and synaptopathies." Doctoral thesis, Universitat Autònoma de Barcelona, 2019. http://hdl.handle.net/10803/667389.

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Les densitats postsinàptiques (DPSs) de les sinapsis en espines dendrítiques expressen més de 2.000 proteïnes, dotant a les neurones de plasticitat sinàptica necessària per a la cognició i el comportament. Algunes de les proteïnes més abundants de la DPS són SynGAP i les Shanks. En ratolins, similar a altres mamífers, el gen Syngap1 codifica per diferents isoformes que varien en el seu N- i C-terminal. Mutacions en SYNGAP1 humà causa un forma de retard mental autosòmic de tipus 5 (de l’anglès MRD5), el qual es caracteritza per discapacitat intel·lectual (DI), epilèpsia i en aproximadament un 5

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3

Goulet, Matthew George. "Adaptable rescue system /." Online version of thesis, 1995. http://hdl.handle.net/1850/12258.

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4

Berg, Olle, and Johan Bergström. "Advanced rescue detector : Design and development of an improved rescue antenna." Thesis, KTH, Maskinkonstruktion (Inst.), 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-157151.

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Developed for avalanche rescue, the RECCO Rescue System is used by more than 700 rescue organizations around the world to find buried avalanche victims and missing people. The RECCO system consists of two parts: a passive reflector integrated into clothing, boots, helmets, and body protection worn by skiers and riders; and an active detector used by organized rescue teams. As of 2009 the active part of RECCO system now utilizes a small hand-held detector named R9, which can easily be carried by one rescuer travelling on foot or from in a helicopter and has a range of more than 200 meters. From

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5

Perez, Carlos M. "Anatomy of a hostage rescue : what makes hostage rescue operations successful /." Thesis, Monterey, Calif. : Springfield, Va. : Naval Postgraduate School ; Available from National Technical Information Service, 2004. http://library.nps.navy.mil/uhtbin/hyperion/04Sep%5FPerez.pdf.

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Thesis (M.S. in Defense Analysis)--Naval Postgraduate School, Sept. 2004.<br>Thesis Advisor(s): Frank R. Giordano, Gordon H. McCormick. Includes bibliographical references (p. 179-189). Also available online.

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6

Blakeman, Mary. "The Rhetoric of Rescue." TopSCHOLAR®, 1990. https://digitalcommons.wku.edu/theses/2142.

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This thesis examines the television reporters' verbal depictions of two rescue events, the rescue of Jessica McClure in 1987 and the rescue of three whales at Pt. Barrow, Alaska in 1988, in order to discover what rhetorical techniques were used to appeal to the public interest. Analog criticism, metaphorical analysis and pentadic analysis were used to discover the dominant language reporters chose. Three main conclusions were drawn from this analysis: (1) use of the dramatistic pentad showed how reporters focused public attention away from the purpose,(2) verbal and visual depictions cannot be

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7

Lebeloane, Virginia Mmule. "An evaluation of business rescue plans based on business rescue principles and guidelines to determine leading indicators of business rescue outcomes." Diss., University of Pretoria, 2017. http://hdl.handle.net/2263/59850.

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The low success rate of business rescue in South Africa has been presented as the research problem in the study. This is because since the inception of Chapter 6 of the Companies Act, No. 78 of 2008 in 2011, there has been an average success rate of nine percent. This is fairly low compared to countries like the United Kingdom and the United States of America whose regimes inspired the development this Chapter 6. As a result, the study focuses on evaluating business rescue plans of past experiences based on the principles and guidelines stated in Chapter 6. The archival research compares what

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8

Tlhapi, Onkabetse Matlhogonolo. "Rescuing creditors from business rescue : dissecting the detrimental effects of business rescue on creditors." Diss., University of Pretoria, 2020. http://hdl.handle.net/2263/75318.

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This dissertation critically analyses the business rescue regime, with a specific focus on those attributes of the regime which detrimentally affect creditors. The main aspects which will be critically analysed include, the moratorium, the effect of business rescue on suretyships and the costs of business rescue. Examples will be used to illustrate the ways in which the business rescue regime is disproportionately slanted in favour of debtor companies as opposed to their creditors. Proposals as to how the regime can be developed to balance the competing interests of debtor companies and their

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9

Ruan, Hui Yu. "Robot rescue : an interactive game /." Online version of thesis, 2006. https://ritdml.rit.edu/dspace/handle/1850/2802.

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10

Ghanem, Alexander. "Innovations in rabies virus rescue." Diss., Ludwig-Maximilians-Universität München, 2012. http://nbn-resolving.de/urn:nbn:de:bvb:19-183116.

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11

Rabby, Md Hasib Mahmud. "Tethered drone for rescue boats." Thesis, KTH, Skolan för elektroteknik och datavetenskap (EECS), 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-290819.

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Human has a great interest in aerial devices from very ancient days. The journey was started by kites and is still going on with the invention of airplane, helicopter, rocket,and many more. Drone is the latest field of scientist’s research which is a miniature of a helicopter. It has a great impact on military unit, navigation, and rescue mission. Inrecent days we can see its use in defense and attack strategies among the developed countries. There are many ways in which the use of drones in practical circumstances can be further explored. For example, in rescue missions, it is sometimes diffi

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12

Burger, Bertus Roux. "Bank Rescue in South Africa." Diss., University of Pretoria, 2017. http://hdl.handle.net/2263/65725.

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The 2008 Global Financial Crisis has revealed the importance of maintaining financial stability. A big threat to the maintenance of financial stability is however bank failure. Especially if a bank is systemically important due to its size and interconnectedness it may propagate contagion and bank runs and trigger the collapse of a whole financial system. It is therefore pertinent that the issue of bank failures be addressed, preferably by extending assistance to such a failing bank where appropriate. In South Africa bank rescue is currently facilitated in terms of section 69 of the Banks Act

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13

Prins, Deon. "Priority issues in business rescue." Master's thesis, University of Cape Town, 2015. http://hdl.handle.net/11427/16728.

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Includes bibliographical references<br>The status of a creditor has always been vitally important in South African law. Our law contains numerous provisions - amongst others in the law of insolvency - to protect creditor's rights, that is, the ability of creditors to collect from debtor s what they are owed. Traditionally secured creditors - that is, creditors who hold some form of real security for their claim - rank higher in priority when it comes to repayment of their claims by a defaulting debtor, both in individual and collective debt enforcement procedures, and as such are, in the vast

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14

Igneski, Violetta. "Rescue and the duty to aid." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/NQ59046.pdf.

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15

Litter, Jansen J. "Mobile robot for search and rescue." Ohio : Ohio University, 2004. http://www.ohiolink.edu/etd/view.cgi?ohiou1176921842.

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16

Nishimoto, Craig Takeshi. "Duties of Rescue: a Moderate Account." Thesis, Harvard University, 2013. http://dissertations.umi.com/gsas.harvard:11197.

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This dissertation clarifies a challenge present in Peter Singer's famine-relief argument and offers a new account of our moral duties of rescue. The challenge, in essence, is to differentiate two classes of idealized rescue scenarios where one faces the opportunity to rescue someone from serious peril, and to differentiate them in way that both avoids a shockingly demanding conclusion and effectively counteracts the suspicion that one is maintaining and merely rationalizing a self-serving position. To meet this challenge I provide an account whereby both the extent and the limits of our resc

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17

Steen, Thor Audun. "Search and Rescue Mission Using Multicopters." Thesis, Norges teknisk-naturvitenskapelige universitet, Institutt for teknisk kybernetikk, 2014. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-25925.

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Search and rescue operations can greatly benefit from the use of autonomous unmanned aerial systems to survey the environment and collect evidence about the positions of missing persons. This thesis considers the design of an autonomous multicopter system for use in a search and rescue mission. The ArduPilot Mega is used as the autopilot and is presented together with detailed information about the utilized hardware and software. The design of a low- level control interface is implemented as an extension to APM:Copter using the MAVLink protocol allowing attitude or velocity control of the mult

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18

Adson, Artur, and Timu Matin. "Further Development of A Rescue Helmet." Thesis, KTH, Maskinkonstruktion (Inst.), 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-177798.

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The aim of this master's thesis was to further develop a helmet for search and rescue personnel, on request from AUK Protection, formerly known as Baering. This thesis succeeds the KTH MF2061 higher course project Baering Y1 - Product development of a new search and rescue helmet in collaboration with Baering in 2013. AUK Protection had identified a need for a purposely designed helmet through contact with members of Swedish Search and Rescue(SAR) and Swedish Sea Rescue Society(SSRS). There are approximately 2000 active SAR and SSRS members who use helmets designed for recreational activities,

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19

Van, der Merwe Dallie. "Requirements to commence business rescue proceedings." Diss., University of Pretoria, 2018. http://hdl.handle.net/2263/65629.

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20

Cozic, Gaelle. "A Common Tomorrow : Kajulu Rescue Center." Thesis, Umeå universitet, Arkitekthögskolan vid Umeå universitet, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-133143.

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21

Campbell, Elaine. "Arginine deprivation therapy : tumour cell rescue." Thesis, University of Aberdeen, 2003. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU179590.

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In order to evaluate arginine deprivation as a putative anticancer therapy this study investigated arginine metabolism at the molecular, cellular and whole animal levels. Firstly, a murine model for arginine deprivation was developed using the catabolic enzyme arginase to reduce the blood arginine levels in vivo. However, although the arginine levels were limiting to both host and tumour, no prolongation in survival time was noted between treated and control groups. Analysis of the L1210 lymphocytic leukaemia cells used in this study revealed their ability to recycle arginine from its precurso

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22

Brinkley, Maddison-Lee. "Role conflict of business rescue practitioners." Diss., University of Pretoria, 2016. http://hdl.handle.net/2263/60512.

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23

Gant, J. L. L. "Rescue before a fall : an Anglo-French analysis of the balance between corporate rescue and employment protection." Thesis, Nottingham Trent University, 2016. http://irep.ntu.ac.uk/id/eprint/29038/.

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The financial crisis of 2007/8 has had a significant impact on the place of social policy objectives in the Common Market. As laws have been reformed over the years since the failure of Lehman Brothers set in motion a domino effect among high risk investment banks and financial institutions throughout the economically advanced nations of this world, both employment protection and corporate rescue have been found, at times, in the spotlight. While the corporate rescue culture of the European Union promotes the rehabilitation of businesses in financial distress in preference to liquidation where

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24

Prater, Amberle M. "First Responders in Rescue-Based Work: A Phenomenological Case Study of Rural Rope and Rappel Rescue Workers." Ohio University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1521107236072826.

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25

Mort, Alasdair. "Novel electronic physiologic monitor potential in remote and rural search and rescue." Thesis, University of Aberdeen, 2010. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=158403.

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This thesis evaluates novel electronic physiologic monitor potential in remote and rural search and rescue. Casualties are often located a considerable distance away from definitive care. Their rescue involves a variety of groups, including volunteer rescue teams. Rescuers manage a wide range of medical problems, from minor issues to more serious, life-threatening conditions. However, casualty monitoring is restricted by steep terrain and extreme environmental conditions. Evidence indicated that novel electronic physiologic monitors were in development. Some were lightweight and wireless – it

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26

James, Scott M. "Reason for rescue an essay on beneficence /." College Park, Md. : University of Maryland, 2005. http://hdl.handle.net/1903/2693.

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Thesis (Ph. D.) -- University of Maryland, College Park, 2005.<br>Thesis research directed by: Philosophy. Title from t.p. of PDF. Includes bibliographical references. Published by UMI Dissertation Services, Ann Arbor, Mich. Also available in paper.

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27

Cavallin, Kristoffer, and Peter Svensson. "Semi-Autonomous,Teleoperated Search and Rescue Robot." Thesis, Umeå University, Department of Computing Science, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-31928.

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<p>The interest in robots in the urban search and rescue (USAR) field has increased the last two decades. The idea is to let robots move into places where human rescue workers cannot or, due to high personal risks, should not enter.In this thesis project, an application is constructed with the purpose of teleoperating a simple robot. This application contains a user interface that utilizes both autonomous and semi-autonomous functions, such as search, explore and point-and-go behaviours. The purpose of the application is to work with USAR principles in a refined and simplified environment, and

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28

Warler, Matthias. "Failing company defense, Sanierungsfusion und rescue merger." Baden-Baden Nomos, 2008. http://d-nb.info/989491358/04.

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29

Osmond, Matthew. "Eco-evolutionary rescue: an adaptive dynamic analysis." Thesis, McGill University, 2012. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=107917.

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Populations exposed to changing environments often decline in abundance and may therefore find themselves at risk of extinction. Safe abundances can be regained, and persistence secured, when populations can adapt fast enough. Here I ask how population and environmental factors determine a population's ability to persist in changing environments by adapting genetically. In Chapter 2 I investigate the response to a gradual, directional change in the environment and in Chapter 3 I investigate the response to a sudden, sustained shift. Chapter 3 also discusses the effects of interspecific competi

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30

Wang, Zhelong. "Design study of an earthquake rescue robot." Thesis, Durham University, 2004. http://etheses.dur.ac.uk/2811/.

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This thesis describes the design of a brush robot for earthquake rescue and for traversing pipes with varied cross sectional shape. Earthquake rescue is a very dangerous, difficult and challenging task, in which emergency services rescue people who are trapped in man-made structures, such as collapsed buildings after an earthquake. The building collapse may have been caused by natural or man-made events. This technology is also applicable to tunnel collapse and land slips. The focus of this work is finding the location of victims and provision of primary life support and communications. To ill

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31

Gandhi, Sapan. "Molecular Mechanisms of Kinetochore Dependant Microtubule Rescue." Thesis, University of Dundee, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.500640.

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32

Mosesson, Yael, and Petra Nyqvist. "Tracking with search and rescue dog equipage." Thesis, Linköpings universitet, Kommunikations- och transportsystem, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-119940.

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Sjöfartsverket ansvarar för insatser när människor är i, eller befaras vara i sjönöd. För att utveckla metoderna för efterforskning av försvunna människor i sjönöd har Sjöfartsverket tillsammans med Sjöräddningssällskapet, Svenska Brukshundklubben och Myndigheten för samhällsskydd och beredskap (MSB) startat ett projekt tillsammans med räddningshundar som specialutbildats för att agera i sjömiljö, så kallade sjöräddningshundekipage. Syftet har varit att genom intervjuer och observationer ta reda på vilka sökmetoder som används för eftersök av försvunna människor på land med räddningshundar för

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33

Bamias, Christina. "Analysis of clinical trials with rescue medication." Thesis, London School of Hygiene and Tropical Medicine (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.249574.

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34

Stewart, M. H. "Embryo rescue for interspecific hybrids in Vicia." Thesis, University of Reading, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.383531.

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35

Kakisi, Ourania. "Rescue of murine gammaretroviruses in human cells." Thesis, Imperial College London, 2017. http://hdl.handle.net/10044/1/61533.

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Murine leukaemia viruses (MLVs) are simple γ-retroviruses of mice that are endogenous to the mouse genome, with several being replication-competent. In 2006, a research group using virus arrays, identified a novel MLV recombinant, XMRV, in human prostate cancer (PCa) tissue and cell lines. The virus appeared to infect and replicate efficiently in human cells. Disease associations with PCa and chronic fatigue syndrome caused a worldwide concern over the presence of XMRV in the human blood supply and patient populations. The final conclusions settled in 2011, and XMRV was widely accepted as a re

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36

Adebola, B. A. "Corporate rescue and the Nigerian insolvency system." Thesis, University College London (University of London), 2013. http://discovery.ucl.ac.uk/1385156/.

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Foremost insolvency practitioners are agitating for the reform of the Nigerian corporate insolvency law, and in particular, its rescue system. They seek to transplant the corporate rescue model of either the United States or of England and Wales into the Nigerian insolvency system. On the premise that the present system, as well as the proposed models should be clearly understood before reforms are executed, this thesis examines the three rescue models in focus. Very little is written on the existing Nigerian rescue system. Utilising an analytical and empirical method, the thesis educes a robu

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37

Meyer, K. C. (Kobus Cornelius). "Development of a GIS for sea rescue." Thesis, Stellenbosch : Stellenbosch University, 2003. http://hdl.handle.net/10019.1/53360.

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Thesis (MA)--Stellenbosch University, 2003.<br>ENGLISH ABSTRACT: Saving the life of another person cannot be measured in monetary terms. It is also impossible to describe the satisfactiori of carrying out a successful rescue to anybody. However, the disappointment and sense of failure when a rescue mission fails and a life is lost, is devastating. Many rescue workers, including those of the National Sea Rescue Institute (NSRI), have experienced this overwhelming sense of failure. Rescue workers often dwell on failed rescue attempts, wishing that they could have arrived on the scene earli

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38

Mardell, James. "Assisting search and rescue through visual attention." Thesis, Imperial College London, 2014. http://hdl.handle.net/10044/1/24156.

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With the ubiquity of visual data being recorded, we now have the ability to view vast amounts of visual imagery. However, searching through imagery for an indeterminate target in tasks such as security baggage inspection, medical scan screening and Wilderness Search and Rescue (WiSAR), remains problematic for most people and cannot be automated. If the imagery was presented to account for the way in which humans cognitively process such visuals, then the success of these tasks might be improved. This thesis proposes and evaluates a series of presentation methods to manipulate imagery to seek t

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39

Anild, Sara, and Niklas Roos. "Image- and Video Coding for Rescue Operations." Thesis, KTH, Skolan för elektro- och systemteknik (EES), 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-199254.

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Bando, Yoshiaki. "Robust Audio Scene Analysis for Rescue Robots." Kyoto University, 2018. http://hdl.handle.net/2433/232410.

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41

Beck, Zoltan. "Collaborative search and rescue by autonomous robots." Thesis, University of Southampton, 2016. https://eprints.soton.ac.uk/411031/.

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In recent years, professional first responders have started to use novel technologies at the scene of disasters in order to save more lives. Increasingly, they use robots to search disaster sites. One of the most widely and successfully used robot platforms in the disaster response domain are unmanned aerial vehicles (UAVs). UAVs allow remote inspection and mapping. They are able to provide high resolution imagery and often need minimal infrastructure to fly. This allows settings where multiple UAVs are airborne accelerating the information gathering from the disaster site. However, current de

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42

Moolla, Muhammud. "Business rescue in practice : a comparative study." Diss., University of Pretoria, 2017. http://hdl.handle.net/2263/64888.

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South Africa is experiencing constrained economic growth with a domestic growth rate for 2017, of less than one percent. This has dictated a harsh environment for South African businesses which are the back bone of the economy, providing much needed jobs. Based on international best practice, South African legislation allows an opportunity for recovery in the form of business rescue as an alternative to liquidation of the business. Using qualitative, semi-structured interviews with an inductive approach a comparison was made between business rescue in South Africa and the parallel practice of

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Alves, Pedro César Fonseca Gonçalves. "RoboCup rescue : development of inteligent cooperative agents." Master's thesis, Universidade de Aveiro, 2008. http://hdl.handle.net/10773/2047.

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Mestrado em Engenharia de Computadores e Telemática<br>O trabalho desenvolvido nesta dissertação tem como tema o desenvolvimento de um agente inteligente com coordenação e comunicação no ambiente RoboCup Rescue. No RoboCup Rescue existem seis tipos de agentes, no entanto nesta tese só dois agentes foram desenvolvidos, especificamente o tipo de agentes Ambulâncias e Centros de Ambulâncias. O tipo de agente Ambulância é o elemento responsável pelo salvamento de civis na cidade virtual que constitui o ambiente RoboCup Rescue. Para cumprir essa tarefa da forma mais eficiente possível conta com coo

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Shaw, Michelle. "Rescue from over-indebtedness? : Christians against poverty." Thesis, Bangor University, 2015. https://research.bangor.ac.uk/portal/en/theses/rescue-from-overindebtedness-christians-against-poverty(15c3e717-ce92-46c9-9804-a9376598c655).html.

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Unmanageable personal debt creates a situation that is commonly described as “over-indebtedness.” Over-indebtedness has caused millions of people across the UK to seek advice for their situations which they feel powerless to resolve themselves. This thesis examines the work of one particular debt advice service, Christians Against Poverty (CAP) and its work through a local church, The Helpful Church. CAP provides its debt advice service through local churches so clients can experience the love of God through face to face long term advice and help. The Helpful CAP Centre (HCC) is a local CAP Ce

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45

Tanner, Douglas Ray. "Genetic Analysis of Ribosome Stalling and Rescue." BYU ScholarsArchive, 2009. https://scholarsarchive.byu.edu/etd/2272.

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In eubacteria, ribosome stalling on broken messenger RNA transcripts can lead to cell death. The trans-translation quality control mechanism rescues many of these stalled ribosomes. In this process, tmRNA enters stalled ribosomes by mimicking a transfer RNA, accepting the stalled nascent peptide. The ribosome then releases the broken mRNA and resumes translation on a coding region within tmRNA itself. Translation of tmRNA marks the nascent peptide for destruction by the addition of a short proteolysis tag and the ribosome is released at a stop codon within the tmRNA open reading frame. An intr

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46

Bosman, Justice Selvyn. "Principles of physics implicit in emergency medical rescue education and operational practice: a case study of motor vehicle related rescue." Thesis, Cape Peninsula University of Technology, 2019. http://hdl.handle.net/20.500.11838/2967.

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Thesis (Master of Emergency Medical Care (MEMC))--Cape Peninsula University of Technology, 2019<br>Introduction: Road traffic injuries are the ninth leading cause of death globally. Projections indicate that without new and sustained commitment globally to preventing such injuries, the situation will only worsen. Motor vehicle rescue does not lend itself to the prevention of road traffic incidents but through ensuring that all incidents are managed using sound evidence could contribute in positive outcomes for victims. It is unknown what contribution rescue education makes to the body of medic

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47

LaBaw, S. Marie. "Earth pressure determination in trench rescue shoring systems." College Park, Md.: University of Maryland, 2009. http://hdl.handle.net/1903/9112.

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Thesis (Ph.D.) -- University of Maryland, College Park, 2009.<br>Thesis research directed by: Dept. of Civil and Environmental Engineering. Title from t.p. of PDF. Includes bibliographical references. Published by UMI Dissertation Services, Ann Arbor, Mich. Also available in paper.

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48

Hammerseth, Vegard B. "Autonomous Unmanned Aerial Vehicle In Search And Rescue." Thesis, Norges teknisk-naturvitenskapelige universitet, Institutt for teknisk kybernetikk, 2013. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-22880.

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This report presents a way of using autonomous drones to enhance search and rescue operations and takes the first steps in bringing the system to life. By using autonomous drones, less experience is required by the rescue personnel and drone specialists become excessive in this matter. Due to autonomy a drone can operate outside a valid radio link. Hence, when signal is lost, the craft can continue to search, buffer the information and send it when the link becomes active. By creating affordable drones the threshold decreases for deploying a unit in bad weather or other missions where the feed

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Pope, Robert James Paul. "Transgenic rescue of the galanin knockout nociceptive phenotype." Thesis, University of Bristol, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.520247.

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Ang, H. C. "Biophysical characterisation and rescue of p53 cancer mutants." Thesis, University of Cambridge, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.596120.

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The aim of this thesis was to use biophysical methods to characterise the stabilities and DNA binding properties of monomeric and tetrameric p53 cancer mutants, and to study various approaches aimed at rescuing structural mutants of p53. A detailed study of the destabilising effects of p53 mutations was performed using differential scanning calorimetry and urea denaturation, while equilibrium binding of p53 mutants to a specific promoter sequence, <i>gadd45</i>, was studied using fluorescence anisotropy and analytical ultracentrifugation. This thesis will also discuss how p53 structural mutant

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