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Starr, Talcott Copeland. "Rescue Archaeology." Miami University / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=miami1217341314.
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Gou, Alsina Gemma. "Molecular mechanisms underlying the role of SynGAP in cognition and synaptopathies." Doctoral thesis, Universitat Autònoma de Barcelona, 2019. http://hdl.handle.net/10803/667389.
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Les densitats postsinàptiques (DPSs) de les sinapsis en espines dendrítiques expressen més de 2.000 proteïnes, dotant a les neurones de plasticitat sinàptica necessària per a la cognició i el comportament. Algunes de les proteïnes més abundants de la DPS són SynGAP i les Shanks. En ratolins, similar a altres mamífers, el gen Syngap1 codifica per diferents isoformes que varien en el seu N- i C-terminal. Mutacions en SYNGAP1 humà causa un forma de retard mental autosòmic de tipus 5 (de l’anglès MRD5), el qual es caracteritza per discapacitat intel·lectual (DI), epilèpsia i en aproximadament un 50% dels casos, trets autistes entre altres alteracions.
La primera part d’aquesta tesi es va centrar en l’estudi de les isoformes de SynGAP durant el desenvolupament de ratolí. Usant diferents mètodes, es va quantificar l’abundància relativa i/o absoluta del total de SynGAP i de les isoformes compostes per les variants C-terminal alpha1, alpha2 o beta en cinc àrees cerebrals i quatre estadis diferents del desenvolupament. A més, es va investigar la seva distribució subcel.lular en edats post-natals similars a les anteriors analitzades, alhora que es va confirmar l’expressió d’aquestes isoformes en escorça d’humans. El conjunt d’aquests experiments varen permetre identificar una regulació espacio-temporal i distribució subcel.lular diferencial de SynGAP i les seves isoformes. L’expressió de SynGAP-α1 era restringida a la PSD, mentre que la variant β predominava en el citosol, fins i tot en edat adulta. Les isoformes compostes d’α2 mostraren un patró d’expressió i distribució intermedi al de les altres variants C-terminal. Concretament, SynGAP-α2 predominava en el citosol fins a dia post-natal 21 (DPN21), a partir d’on la seva expressió seria majoritària en la PSD. Atès que en etapes primerenques del desenvolupament SynGAP-β i -γ s’han trobat expressades amb major abundància en comparació a les altres variants, podrien tenir un rol principal en aquests estadis.
La segona part d’aquesta tesi adreçà l’estudi de les alteracions del proteoma de la PSD derivades de l’haploinsuficiència de Syngap1 en hipocamp. El rescat d’aquestes alteracions va ser també investigat en ratolins modificats genèticament per a Syngap1+/- , així com els efectes d’una reducció de SynGAP a la DPS, en ambdós casos a DPN21. Aquests estudis revelaren que els nivells de proteïnes relacionades amb la traducció, la producció d’energia, i les ‘small GTPases” entre altres anomalies, estarien significament alterades en ratolins Syngap1+/- . A més, en recuperar l’expressió normal de SynGAP a partir de DPN21, el ~83% de les alteracions observades van ser revertides. No obstant, algunes alteracions romangueren mentre que altres aparegueren com a conseqüència de la reactivació de Syngap1 en els ratolins rescatats. Aquestes desregulacions feien referència majoritàriament a processos de proteostasis amb un clínica menys severa que en els ratolins no rescatats. La inducció de la reducció de SynGAP a partir del DPN21 també va resultar en canvis dels nivells d’un nombre similar de proteïnes però amb un baix grau de solapament i efecte aparentment menys deleteri que en el cas de ratolins haploinsuficients des de la embriogènesis.
Finalment, es van dur a terme experiments dirigits a desenvolupar ratolins modificats genèticament per a Shank2+/- que alhora permetessin estudis de rescat genètic, ja que mutacions en la família de gens SHANK en humans son potencials causes d’autisme monogènic i altres desordres del neurodesenvolupament tals com la DI.Forebrain postsynaptic densities (PSDs), found in dendritic spines, express more than 2,000 different proteins, endowing neurons with the synaptic plasticity mechanisms required for cognition and behaviour. Some of the most abundant PSD proteins are SynGAP and Shanks. In rodents, like in other mammals, the Syngap1 gene encodes for different isoforms that vary in their N- and C-termini. Mutations in the SYNGAP1 gene cause autosomal mental retardation type five (MRD5), which is characterized by intellectual disability (ID) and epilepsy, as well as autistic traits in approximately half of the affected individuals, among other impairments. The first part of the present thesis focused on the study of SynGAP isoforms during mouse neurodevelopment. Their differential abundance in five different brain regions and four developmental stages were systematically investigated using a variety of molecular approaches that allowed for their relative and absolute quantification. Furthermore, their sub-cellular distribution in similar neurodevelopmental stages and expression in human cortices were studied. This work indicated that out of the six previously unreported SynGAP variants identified in-silico, three and one were found expressed at the transcript or protein level, respectively. The expression of SynGAP isoforms carrying three out of the four C-terminal variants was also demonstrated in human cortex. Importantly, this work identified differential spatio-temporal regulation and subcellular distribution of SynGAP isoforms containing α1, α2 and β C-term variants. Specifically, the expression of SynGAP-α1 isoforms was found highly restricted to the PSD, while β isoforms predominated in the cytosolic fraction, even at PND56. Isoforms bearing the α2 C-term showed an intermediate pattern, having a primarily cytosolic location until PND21 but being mainly at the PSD afterwards. Interestingly, SynGAP-β and -γ isoforms could have a leading role in early stages of cortical development, as they were found particularly abundant compared to the other ones. The second part of this thesis addressed the study of the proteomic alterations derived from Syngap1 haploinsufficiency in the hippocampal PSD. The rescue of these alterations, as well as the effect of SynGAP ablation, both at PND21, was also investigated in two conditional Syngap1+/- mouse lines. These analyses revealed that proteins related to small GTPases, translation and energy production among others, were significantly altered in Syngap1+/- mice. In addition, ~83% of the alterations observed could be recovered if normal SynGAP levels were restored at PND21. Yet, some alterations persisted or newly arose in Syngap1+/- rescued mice. These alterations were mainly associated to protein processing at endoplasmic reticulum, transport of small molecules and proteasomal degradation. Based on gene set enrichment analyses, the molecular alterations observed after SynGAP rescue would be compatible with a less clinically severe scenario. Lastly, the induction of SynGAP deficit at PND21 resulted in a similar number of altered proteins as in embryonic Syngap1 haploinsufficiency, yet these two scenarios shared few affected proteins, suggesting a developmental role in the molecular alterations observed in the embryonic deficit of SynGAP. Finally, the present thesis also includes a series of experiments aimed at developing a Shank2+/- mouse model for genetic rescue experiments, as mutations in SHANK genes are a potential monogenic cause for ASD and other neurodevelopmental disorders, including ID.
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Goulet, Matthew George. "Adaptable rescue system /." Online version of thesis, 1995. http://hdl.handle.net/1850/12258.
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Berg, Olle, and Johan Bergström. "Advanced rescue detector : Design and development of an improved rescue antenna." Thesis, KTH, Maskinkonstruktion (Inst.), 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-157151.
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Developed for avalanche rescue, the RECCO Rescue System is used by more than 700 rescue organizations around the world to find buried avalanche victims and missing people. The RECCO system consists of two parts: a passive reflector integrated into clothing, boots, helmets, and body protection worn by skiers and riders; and an active detector used by organized rescue teams. As of 2009 the active part of RECCO system now utilizes a small hand-held detector named R9, which can easily be carried by one rescuer travelling on foot or from in a helicopter and has a range of more than 200 meters. From being a big, heavy and unhandy device the detector has gone through an extensive development since the start. The original detector had a long pointing antenna which created very accurate antenna beams but since the device has become smaller, so has the antenna. Therefore, the antenna beams have become less directional, and consequently the accuracy has decreased. The next generation of detectors, called R10, will be based on the existing R9, but needs to be equipped with a longer antenna. Keeping the same size as the R9, the antenna needs to be extendable. This problem lead to the following goal for this master thesis: by the use of a sufficient development process; improve the antenna of RECCO’s R9 detector by increasing its length to give it a better search performance, but still keep it practical and robust. The project was implemented with a spiral development process divided into 6 phases, where different methods suitable for the project were integrated. A lot of time and focus were spent on 3Dmodelling and rapid prototyping for concept testing and validation. The result of the thesis is a radically changed, production ready, antenna design. The antenna has rotated 90 degrees as well as doubled in length, giving it a better search performance; although it is still a practical and robust design that can handle the tough requirements that an avalanche situation demands. The solution consists of a divisible three part system that is mounted together with a rubber cord, and connected to the detector with a snap fit system.RECCO Rescue System är utvecklat och framtaget för lavinräddning och används av mer än 700 räddningsorganisationer runt om i världen för att hitta begravda lavinoffer och saknade personer. Systemet består av två delar: en passiv reflektor som är integrerad i kläder, pjäxor, hjälmar och skydd burna av skidåkaren; och en aktiv detektor som används av de organiserade räddningspatrullerna. Sen 2009 har den aktiva delen i RECCO-systemet bestått av en handhållen detektor kallad R9. Den kan enkelt bäras av en räddningsarbetare som rör sig till fots eller i en helikopter och har en räckvidd på mer än 200 meter. Från att ha varit en stor, tung och opraktisk apparat har detektorn gått igenom en stor utvecklingsprocess sedan starten. Den första detektorn hade en lång antenn, som skapade en väldigt exakt antennlob, men när detektorn blev mindre blev också antennen förminskad. Det har fört med sig att antennloben har blivit mindre exakt och noggrannheten har därför minskats. Nästa generations detektor, kallad R10, kommer att baseras på existerande R9, men behöver utrustas med en längre antenn. Då den ska vara i samma storlek som R9, kommer antennen behöva vara utfällbar. Det problemet har gett följande mål för den här examensrapporten: med hjälp av en passande utvecklingsprocess; förbättra antennen på RECCOs R9 detektor genom att förlänga den och därmed ge den bättre noggrannhet, men samtidigt hålla den praktiskt och robust, samt att göra den produktionsredo. Projektet utfördes med hjälp av en spiral utvecklingsprocess uppdelad i 6 faser, där olika metoder, passande för projektet, var integrerade i varje fas. Mycket tid spenderades på 3Dmodellering och prototyptillverkning för att testa och validera olika koncept. Resultatet av examensarbetet är en radikalt ändrad och produktionsredo antenndesign. Antennen har roterats 90 grader samt dubblats i längd vilket ger den en bättre söknoggrannhet; trots det är det fortfarande en praktiskt och robust design som han hantera de tuffa kraven som en lavinolycka kräver. Lösningen består av ett delbart tredelars system som hålls ihop av ett gummiband, och sitter fast i detektorn med ett snäppfäste.
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Perez, Carlos M. "Anatomy of a hostage rescue : what makes hostage rescue operations successful /." Thesis, Monterey, Calif. : Springfield, Va. : Naval Postgraduate School ; Available from National Technical Information Service, 2004. http://library.nps.navy.mil/uhtbin/hyperion/04Sep%5FPerez.pdf.
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Thesis (M.S. in Defense Analysis)--Naval Postgraduate School, Sept. 2004.Thesis Advisor(s): Frank R. Giordano, Gordon H. McCormick. Includes bibliographical references (p. 179-189). Also available online.
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Blakeman, Mary. "The Rhetoric of Rescue." TopSCHOLAR®, 1990. https://digitalcommons.wku.edu/theses/2142.
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This thesis examines the television reporters' verbal depictions of two rescue events, the rescue of Jessica McClure in 1987 and the rescue of three whales at Pt. Barrow, Alaska in 1988, in order to discover what rhetorical techniques were used to appeal to the public interest. Analog criticism, metaphorical analysis and pentadic analysis were used to discover the dominant language reporters chose. Three main conclusions were drawn from this analysis: (1) use of the dramatistic pentad showed how reporters focused public attention away from the purpose,(2) verbal and visual depictions cannot be separated when studying television news stories and (3) two different styles of depiction were used to portray two very similar events.
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Lebeloane, Virginia Mmule. "An evaluation of business rescue plans based on business rescue principles and guidelines to determine leading indicators of business rescue outcomes." Diss., University of Pretoria, 2017. http://hdl.handle.net/2263/59850.
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The low success rate of business rescue in South Africa has been presented as the research problem in the study. This is because since the inception of Chapter 6 of the Companies Act, No. 78 of 2008 in 2011, there has been an average success rate of nine percent. This is fairly low compared to countries like the United Kingdom and the United States of America whose regimes inspired the development this Chapter 6. As a result, the study focuses on evaluating business rescue plans of past experiences based on the principles and guidelines stated in Chapter 6. The archival research compares what companies that came out of business rescue successfully did as opposed to those that were not successful. This assessment focused on finding any unique leading indicators of business rescue; and if compliance to the principles and guidelines of Chapter 6 is crucial for the outcome of business rescue and if there is material difference between business rescue plans of listed companies and unlisted companies. The objective of this study is to identify what makes strong and effective business rescue plans and what pitfalls need to be avoided when developing future business rescue plans.
In order to meet this objective, the study was guided by the stakeholder theory since the South African business rescue regime is creditor friendly and aim to observe the rights of affected parties in business rescue. Anchoring the study on this theory then guided the literature review to focus on the Act as the main source of literature to establish the structure of a typical business rescue plan, to know who the affected parties are, their ranking and why the principles and guidelines stated in Chapter 6 are important. Further literature review focused on articles from local and international from law; change management; and business management journals.
The research methodology applied was qualitative in nature so that the reasons for rescue success and failure can be explored. The findings were further validated by interviewing business rescue practitioners. The research findings indicated that all business rescue plans are uniform in structure but there are common strategies that are applied in the business rescue practice to restore companies back to being going concerns. Compliance with Chapter 6 is ideal but not crucial for success and that listed companies provide the BRPs with more data to work with. This then results in more detailed plans that are effective. One of the findings that was of significance is that business rescue outcome is also affected by the conduct of the professionals in the practice.Mini Dissertation (MBA)--University of Pretoria, 2017.
pa2017
Gordon Institute of Business Science (GIBS)
MBA
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Tlhapi, Onkabetse Matlhogonolo. "Rescuing creditors from business rescue : dissecting the detrimental effects of business rescue on creditors." Diss., University of Pretoria, 2020. http://hdl.handle.net/2263/75318.
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This dissertation critically analyses the business rescue regime, with a specific focus on those attributes of the regime which detrimentally affect creditors. The main aspects which will be critically analysed include, the moratorium, the effect of business rescue on suretyships and the costs of business rescue. Examples will be used to illustrate the ways in which the business rescue regime is disproportionately slanted in favour of debtor companies as opposed to their creditors. Proposals as to how the regime can be developed to balance the competing interests of debtor companies and their creditors will also be made.Mini Dissertation (LLM (Corporate Law))--University of Pretoria, 2020.
Mercantile Law
LLM (Corporate Law)
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Ruan, Hui Yu. "Robot rescue : an interactive game /." Online version of thesis, 2006. https://ritdml.rit.edu/dspace/handle/1850/2802.
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Ghanem, Alexander. "Innovations in rabies virus rescue." Diss., Ludwig-Maximilians-Universität München, 2012. http://nbn-resolving.de/urn:nbn:de:bvb:19-183116.
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Rabby, Md Hasib Mahmud. "Tethered drone for rescue boats." Thesis, KTH, Skolan för elektroteknik och datavetenskap (EECS), 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-290819.
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Human has a great interest in aerial devices from very ancient days. The journey was started by kites and is still going on with the invention of airplane, helicopter, rocket,and many more. Drone is the latest field of scientist’s research which is a miniature of a helicopter. It has a great impact on military unit, navigation, and rescue mission. Inrecent days we can see its use in defense and attack strategies among the developed countries. There are many ways in which the use of drones in practical circumstances can be further explored. For example, in rescue missions, it is sometimes difficult for rescuers to reach the spot of the accident, which might be in the middle of a sea or an ocean. A navigation technology that will lead them towards the destination therefore can be of immense use. Rescue organizations like the Swedish Sea Rescue Society (SSRS) are in lack of such a technology that can assist them further in their mission. A tethered drone can act as navigation guidance for them to reach the destination very quickly. It will save time and fuel by reaching the destination via the shortest possible way. Its birds’ eye technology and sensor will broaden the chances of successful rescues. The current similar technologies have some drawbacks. An ordinary drone is generally powered by a battery and therefore has limited flight time. During the flight, it can record and sends a live video stream to a base station via the mobile network. The information collected is intended to be used to assist in crucial rescue decisions such as which boat to use, rescue crew size, what instruments to carry, and so forth. A tethered drone can fly longer than the average flight time. Due to being powered from the ground with wire, the drone gets constant power supply that does not depend on batteries with limited life. The main aim of this thesis is to design a system in which a drone can fly longer in a fixed position and altitude and to find suitable wire for wiring up and ensure the drone’s weight balance. Da-Jiang Innovations spark drone has been used for implementing the project as a model drone and the task is divided into few parts by testing process. Dronesflight time limitations have been overcome and longer flight time has been achieved. Also, because of testing, a few other limitations have been found.Människan har alltid haft ett stort intresse för flygande objekt sedan långt tillbaka.Resan började med drakar och intresset pågår fortfarande med uppfinnigar somflygplan, helikopter, raket och många fler. Drönare är det senaste forskningsområdetsom är en miniatyr av en helikopter. Det har stor inverkan på militära enheter,navigering och räddningsuppdrag. Under de senaste dagarna kan vi se dess användningi försvars- och attackstrategier bland de utvecklade länderna.Det finns många sätt på vilket användningen av drönare under praktiska omständigheterkan utforskas ytterligare. Till exempel i räddningsuppdrag är det ibland svårt förräddare att nå platsen för olyckan, som till exempel kan vara mitt i ett hav.Navigeringsteknik som leder räddningstjänsten mot destinationen kan därför vara tillstor nytta. Räddningsorganisationer som Swedish Sea Rescue Society saknar sådanteknik som kan hjälpa dem ytterligare i deras uppdrag. En kabel bunden drönare kanfungera som navigeringsvägledare för dem att nå destinationen snabbare. Det spararbåde tid och bränsle genom att nå destinationen på kortast möjliga väg. Dessfågelperspektiv och sensor kommer att öka chanserna till framgångsrika räddningar.Den nuvarande liknande tekniken har vissa nackdelar. En vanlig drönare drivsvanligtvis av ett batteri och har därför begränsad flygtid. Under flygningen kan denspela in och skicka en live videoström till en basstation via mobilnätet. Den insamladeinformationen är avsedd att användas för att hjälpa till med viktiga räddningsbeslut somtill exempel vilken båt som ska användas, räddningsbesättningens storlek, vilkainstrument som ska bäras och så vidare.En bunden drönare kan flyga längre än den genomsnittliga flygtiden på grund av attden drivs från marken med kabel får drönaren konstant strömförsörjning som inte berorpå batterier med begränsad livslängd.Huvudsyftet med denna avhandling är att utforma ett system där en drönare kan flygalängre i en fast position och höjd och att hitta en lämplig ledare för kabeldragning ochsäkerställa drönarens viktbalans. Da-Jiang Innovations drönare Spark har använts föratt genomföra projektet som en model drönare och uppgiften är uppdelad i få delargenom testprocess. Drönarnas flygtidsbegränsningar har övervunnits och längre flygtidhar uppnåtts. Dessutom har ny begränsningar hittats efter flera tester har utförts.
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Burger, Bertus Roux. "Bank Rescue in South Africa." Diss., University of Pretoria, 2017. http://hdl.handle.net/2263/65725.
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The 2008 Global Financial Crisis has revealed the importance of maintaining financial stability. A big threat to the maintenance of financial stability is however bank failure. Especially if a bank is systemically important due to its size and interconnectedness it may propagate contagion and bank runs and trigger the collapse of a whole financial system. It is therefore pertinent that the issue of bank failures be addressed, preferably by extending assistance to such a failing bank where appropriate. In South Africa bank rescue is currently facilitated in terms of section 69 of the Banks Act 94 of 1990 that provides for the Minister of Finance, on recommendation by the Registrar of Banks, to appoint a curator for a bank that is unable to pay its debts as they become due. The process of curatorship is however deficient when it comes to dealing with banks that are failing but of which some part may be rescued. This deficiency was revealed during the rescue of African bank when some innovative amendments had to be effected urgently to the Banks Act by means of the Banks Amendment Act 3 of 2015. This dissertation explores the concept of curatorship and how the curatorship process and powers of the curator was changed as a result of the problems posed by the collapse of African Bank. It looks into the restructuring of the bank and also discusses the complimentary process of the investigation into the affairs of a failing bank as set out in section 69A of the Banks Act. The dissertation further looks into international developments in the context of the prevention and mitigation of bank failures. Spesific regard is had to the Financial Stability Board's Key Attributes of Effective Resolution Regimes for Financial Institutions, pointing out that the rescue of African Bank actually comprised of bank resolution rather than curatorship in the strict sense.Mini Dissertation (LLM)--University of Pretoria, 2017.
Mercantile Law
LLM
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Prins, Deon. "Priority issues in business rescue." Master's thesis, University of Cape Town, 2015. http://hdl.handle.net/11427/16728.
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Includes bibliographical referencesThe status of a creditor has always been vitally important in South African law. Our law contains numerous provisions - amongst others in the law of insolvency - to protect creditor's rights, that is, the ability of creditors to collect from debtor s what they are owed. Traditionally secured creditors - that is, creditors who hold some form of real security for their claim - rank higher in priority when it comes to repayment of their claims by a defaulting debtor, both in individual and collective debt enforcement procedures, and as such are, in the vast majority of cases, able to recover full or at least partial repayment of their claims. Business rescue was introduced into South African l aw with the commencement of the Companies Act 71 of 2008, which became effective on 1 May 201 1. Business rescue is a relatively new collective debt enforcement mechanism applicable to corporate debtors. There has been considerable uncertainty with regards to the interpretation of some of its provisions, mainly due to important concepts and terms not being defined. This uncertainty has extended to the provisions dealing with the extension of finance to a corporate debtor after commencement of the business rescue proceedings (so-called 'post-commencement finance') and the ranking of priority of creditors of such corporate debtor during the business rescue proceedings. The dissertation firstly seeks to explain the concept of business rescue, with specific emphasis on post-commencement finance. The relevant provisions relating to post-commencement finance are interpreted along the lines of recent principles governing statutory interpretation. An apparent conflict in the interpretation of these provisions is identified through specific reference to the limited number of judicial pronouncements on this subject matter to date. In attempting to resolve the apparent conflict in the interpretation of the relevant provisions, the dissertation then briefly considers the background to business rescue in South Africa. The Companies Act itself is considered, with specific reference to its stated purpose and objects, along with a look at the historical development of the specific provisions in question. A brief review is then undertaken of the role and f unction of real security in a collectively debt enforcement procedure such as business rescue under South African law, with specific reference to the existing distribution rules in insolvency la w. A comparative review of relevant foreign jurisdictions is then carried out. The dissertation concludes with a suggested approach to the interpretation of the ranking of priorities under business rescue.
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Igneski, Violetta. "Rescue and the duty to aid." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/NQ59046.pdf.
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Litter, Jansen J. "Mobile robot for search and rescue." Ohio : Ohio University, 2004. http://www.ohiolink.edu/etd/view.cgi?ohiou1176921842.
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Nishimoto, Craig Takeshi. "Duties of Rescue: a Moderate Account." Thesis, Harvard University, 2013. http://dissertations.umi.com/gsas.harvard:11197.
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This dissertation clarifies a challenge present in Peter Singer's famine-relief argument and offers a new account of our moral duties of rescue. The challenge, in essence, is to differentiate two classes of idealized rescue scenarios where one faces the opportunity to rescue someone from serious peril, and to differentiate them in way that both avoids a shockingly demanding conclusion and effectively counteracts the suspicion that one is maintaining and merely rationalizing a self-serving position. To meet this challenge I provide an account whereby both the extent and the limits of our rescue duties are determined in ways that are plausibly continuous with moral and practical norms more generally.Philosophy
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Steen, Thor Audun. "Search and Rescue Mission Using Multicopters." Thesis, Norges teknisk-naturvitenskapelige universitet, Institutt for teknisk kybernetikk, 2014. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-25925.
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Search and rescue operations can greatly benefit from the use of autonomous unmanned aerial systems to survey the environment and collect evidence about the positions of missing persons. This thesis considers the design of an autonomous multicopter system for use in a search and rescue mission. The ArduPilot Mega is used as the autopilot and is presented together with detailed information about the utilized hardware and software. The design of a low- level control interface is implemented as an extension to APM:Copter using the MAVLink protocol allowing attitude or velocity control of the multicopter.Furthermore, promising methods for autonomous behavior are discussed and developed with the use of the low-level control interface. The integration of a camera is characterized as a vital part of the fully autonomous search and rescue muliticopter system and presented together with a method used to describe and estimate motion of a target object. The estimator used for the state estimation is the extended Kalman filter.Finally, experiments of the system are conducted at a test field to demonstrate how it can be utilized and to prove the viability of the complete system. The experiments verify that the autonomous search and rescue multicoper can contribute in a search operation using an observer to spot for objects.
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Adson, Artur, and Timu Matin. "Further Development of A Rescue Helmet." Thesis, KTH, Maskinkonstruktion (Inst.), 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-177798.
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The aim of this master's thesis was to further develop a helmet for search and rescue personnel, on request from AUK Protection, formerly known as Baering. This thesis succeeds the KTH MF2061 higher course project Baering Y1 - Product development of a new search and rescue helmet in collaboration with Baering in 2013. AUK Protection had identified a need for a purposely designed helmet through contact with members of Swedish Search and Rescue(SAR) and Swedish Sea Rescue Society(SSRS). There are approximately 2000 active SAR and SSRS members who use helmets designed for recreational activities, such as rafting and mountain climbing, for lack of a better alternative. The helmets are consequently modified to accommodate their specific needs. Essential rescue equipment, such as position lights and communication systems, are retrofit using fasteners, tape, straps and Velcro. User studies conducted in the MF2061 project indicated safety concerns with the aforementioned attachment methods. The retrofit components protrude from the helmet and often interfere with other rescue equipment, with the risk of entangling the user. The Y1 helmet concept produced in the MF2061 project was evaluated together members from SAR and SSRS, with focus on form and functionality. Different materials and manufacturing methods were researched and the manufacturability of the Y1 was analysed. It was ultimately decided to discontinue the development of the Y1 due to the feedback received. New concepts were generated with focus on anthropometric data, manufacturability, helmet safety standards and the ability to mount additional components. Different material combinations were investigated and evaluated using physical testing. Further development of the concepts involved clay sculpting and 3D CAD modelling. The final concept was chosen based on input from the users, AUK Protection and HOWL Design Studio. The R1 -Rescue One helmet is the result and supersedes currently available solutions for rescue applications. The essence of the R1 helmet is a modular mounting system that can be customized for use with third-party components. Prototypes were manufactured in the correct materials for further evaluation. Drop tests were performed according to PAS 028 standard validate the mechanical properties of the helmet.Syftet med denna magisteruppsats var att vidareutveckla en hjälm för livräddningspersonal, som gjordes på begäran från AUK Protection, tidigare känd som Baering. Denna avhandling efterföljer MF2061 högre kurs-projektet Baering Y1 - Product development of a new search and rescue helmet in collaboration with Baering som genomfördes i KTH år 2013. AUK Protection hade identifierat ett behov av en speciellt utformad hjälm genom kontakt med medlemmar i svenska Search and Rescue(SAR) samt Sjöräddningssällskapet(SSRS). Det finns omkring 2000 aktiva SAR och SSRS medlemmar som använder hjälmar avsedda för fritidsaktiviteter, såsom forsränning och bergsklättring, i brist på ett bättre alternativ. Hjälmarna modifieras följaktligen för att tillgodose deras specifika behov. Nödvändig räddningsutrustning, exempelvis positionsljus och kommunikationssystem, monteras på hjälmen med hjälp av skruvar, tejp och kardborreband. Användarstudier i MF2061-projektet indikerade att dessa monteringsmetoder medför säkerhetsrisker. Enligt SAR Norrtälje hakar utstickande komponenter som är monterade på hjälmen ofta fast i övrig räddningsutrustning, med risk för att trassla in användaren. Y1 hjälmkonceptet, som produceras i MF2061-projektet, utvärderades med avseende på form och funktion tillsammans medlemmar från SAR och SSRS. Olika material och tillverkningsmetoder undersöktes och producerbarheten av Y1 analyserades. Det beslutades slutligen att avbryta vidareutvecklingen av Y1 baserat på feedbacken som erhölls. Nya koncept genererades med fokus på antropometrisk data, producerbarhet, säkerhetsstandarder för hjälmar och förmågan att montera ytterligare komponenter. Olika materialkombinationer undersöktes och jämfördes med hjälp av fysiska tester. Vidareutvecklingen av koncept involverade skulptering i lera och 3D CAD modellering. Det slutliga konceptet valdes utifrån input från användarna, AUK Protection och HOWL Design Studio. Resultatet, hjälmen R1 - Rescue One, ersätter tillgängliga lösningar för räddningsapplikationer. Det som utmärker R1-hjälmen är ett modulärt monteringssystem som kan anpassas för användning av tredjepartskomponenter. Prototyper av R1 tillverkades i korrekta material för vidare utvärdering. Falltester utfördes i enlighet med PAS 028 standarden för att validera de mekaniska egenskaperna hos hjälmen.
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Van, der Merwe Dallie. "Requirements to commence business rescue proceedings." Diss., University of Pretoria, 2018. http://hdl.handle.net/2263/65629.
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Cozic, Gaelle. "A Common Tomorrow : Kajulu Rescue Center." Thesis, Umeå universitet, Arkitekthögskolan vid Umeå universitet, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-133143.
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Campbell, Elaine. "Arginine deprivation therapy : tumour cell rescue." Thesis, University of Aberdeen, 2003. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU179590.
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In order to evaluate arginine deprivation as a putative anticancer therapy this study investigated arginine metabolism at the molecular, cellular and whole animal levels. Firstly, a murine model for arginine deprivation was developed using the catabolic enzyme arginase to reduce the blood arginine levels in vivo. However, although the arginine levels were limiting to both host and tumour, no prolongation in survival time was noted between treated and control groups. Analysis of the L1210 lymphocytic leukaemia cells used in this study revealed their ability to recycle arginine from its precursor molecule citrulline even in the presence of the enzyme arginase indicating that the citrulline level may be as important as the arginine level to the generation of deprivation conditions in vivo. Secondly, at the cellular level a number of different immortal cell lines were analysed for their ability to utilise urea cycle intermediates in lieu of arginine in order to identify those tumour types susceptible to the therapy. Most cell lines could be classified as one of the following: Type a - can only be rescued from arginine deprivation conditions with arginine alone; Type b - can utilise arginine and argininosuccinate but not citrulline; Type c can utilise arginine and citrulline but not the intermediate argininosuccinate. This data in addition to the radiolabelled tracer data presented in this thesis supports the theory of metabolite channelling and indicates that the differential utilisation of urea cycle intermediates is not due to metabolite availability within the cell. Finally, since argininosuccinate synthetase (ASS) is the rate limiting step in the conversion of citrulline to arginine the 5' untranslated region of the ASS gene was analysed for differential expression in cell types a, b and c in order to determine if the phenotype differnces noted between the three classes were due to a genotypic difference in the expression of this gene. The region chosen for this study is the site of alternative splicing and although no quantitative or qualitative differnces were observed in either variant 1 or variant 2, three novel bands were also amplified in type c cells but not in type b cells.
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Brinkley, Maddison-Lee. "Role conflict of business rescue practitioners." Diss., University of Pretoria, 2016. http://hdl.handle.net/2263/60512.
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Gant, J. L. L. "Rescue before a fall : an Anglo-French analysis of the balance between corporate rescue and employment protection." Thesis, Nottingham Trent University, 2016. http://irep.ntu.ac.uk/id/eprint/29038/.
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The financial crisis of 2007/8 has had a significant impact on the place of social policy objectives in the Common Market. As laws have been reformed over the years since the failure of Lehman Brothers set in motion a domino effect among high risk investment banks and financial institutions throughout the economically advanced nations of this world, both employment protection and corporate rescue have been found, at times, in the spotlight. While the corporate rescue culture of the European Union promotes the rehabilitation of businesses in financial distress in preference to liquidation where possible, it also emphasises reducing unemployment and social exclusion. The social implications of corporate rescue must therefore be considered, rather than taking a purely economic approach, emphasising creditor wealth maximisation during insolvency proceedings. EU social policy has generated a number of employment regulations, such as the Acquired Rights Directive, which are arguably the greatest obstacle to promoting corporate rescue. Thus there is an enduring conflict that subsists between the aims of corporate rescue and employment protection regulation. Substantial employment protection damages the effectiveness of corporate rescue by deterring acquisitions in view of the potential liability attached to transferring employees. Ineffective corporate rescue may then have an adverse effect on the economy and job security due to increased company failures and job losses. Employees attached to the sale of a business in a corporate rescue procedure can represent a liability, reducing the intrinsic value of that business and potentially reducing the number of businesses successfully rehabilitated through the use of corporate rescue mechanisms. The obstruction to successful corporate rehabilitation represented by employment protection must therefore be balanced with corporate rescue in order to successfully promote the rescue culture. An examination of the approaches taken by different jurisdictions, in this case the United Kingdom and France due to their important influence in the EU as well as their archetypically different legal systems should help elucidate how the tension could be managed in order to achieve a balance between them. The form of examination is particularly important if an effective reform is to be introduced. As such, a comparative historical methodology concentrating on the path dependent legal developments of both jurisdictions will be applied in order to discover the fundamental historical, economic, social, political, and cultural differences between the UK and France that have influenced their approaches to social policy and corporate insolvency law. Legal developments cannot be explained by examining a legal rule in isolation, but must account for the social and economic pressures operating on the law from the outside as well as the established ways in which the issues are dealt with internally. Even when economic and social conditions are similar at the time that a parallel rule is promulgated, the differences in historical journeys to arrive at similar rules can explain why different jurisdictions do not approach new problems in the same way. This thesis will analyse the legal position of employment protection and corporate rescue in the UK and France through a historical comparative analysis of the political, social, and economic developmental context. Based on the understanding of each jurisdiction’s path dependent position within the legal framework of the EU, reform of the ARD will be recommended that attempts to balance the aims of corporate rescue and employment protection in the event of business transfers occurring during corporate rescue procedures. Given that the regulation of this policy intersection is made within the EU legal framework, the comparative historical analysis methodology will assist in identifying the most effective reform that will fit within the varied legal systems of the EU Member States, and also help to predict how such a reform may be implemented over time. This Thesis will provide an innovative contribution to the existing knowledge and literature in the area of social policy in insolvency by using a comparative, historical, path dependent methodology to reveal a potentially effective approach to introducing unique legal reform to the conflicted intersection in the ARD of the promotion of the rescue culture by ensuring effective business transfers in corporate rescue procedures, while providing a balanced protection for employees affected by corporate restructuring.
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Prater, Amberle M. "First Responders in Rescue-Based Work: A Phenomenological Case Study of Rural Rope and Rappel Rescue Workers." Ohio University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1521107236072826.
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Mort, Alasdair. "Novel electronic physiologic monitor potential in remote and rural search and rescue." Thesis, University of Aberdeen, 2010. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=158403.
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This thesis evaluates novel electronic physiologic monitor potential in remote and rural search and rescue. Casualties are often located a considerable distance away from definitive care. Their rescue involves a variety of groups, including volunteer rescue teams. Rescuers manage a wide range of medical problems, from minor issues to more serious, life-threatening conditions. However, casualty monitoring is restricted by steep terrain and extreme environmental conditions. Evidence indicated that novel electronic physiologic monitors were in development. Some were lightweight and wireless – it was hypothesised that such technology could facilitate health monitoring, conferring benefits to casualties and their carers. Novel physiologic monitor potential was explored using a multi-method approach, involving four methodologically distinct pieces of research. This included a reverseengineering approach to define the rescue context. A thematic review of remote and rural casualty rescues identified a potential worldwide demand for a novel monitor, although only a small proportion of casualties had severe injury. A longitudinal analysis of UK remote and rural casualties confirmed a consistent mountain rescue casualty demand for monitoring. Injury was more frequent than illness and a majority of injury involved suspected fracture to the lower extremity. A qualitative study identified evidence of support for novel monitors amongst rescuer groups. However, some felt that the environment and the variety of rescuer first-aid and medical training could negate monitor potential. A laboratory-function study evaluated the performance of an example of a novel monitor under simulated rescue conditions. There was little effect of several layers of clothing and a mountain rescue casualty bag on data accuracy. Taking all the evidence gathered into consideration, it was concluded that novel electronic physiologic monitors did have potential in remote and rural search and rescue. A concept design for a rescue-specific physiologic monitor was proposed, including software, hardware and architecture for future use.
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James, Scott M. "Reason for rescue an essay on beneficence /." College Park, Md. : University of Maryland, 2005. http://hdl.handle.net/1903/2693.
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Thesis (Ph. D.) -- University of Maryland, College Park, 2005.Thesis research directed by: Philosophy. Title from t.p. of PDF. Includes bibliographical references. Published by UMI Dissertation Services, Ann Arbor, Mich. Also available in paper.
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Cavallin, Kristoffer, and Peter Svensson. "Semi-Autonomous,Teleoperated Search and Rescue Robot." Thesis, Umeå University, Department of Computing Science, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-31928.
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The interest in robots in the urban search and rescue (USAR) field has increased the last two decades. The idea is to let robots move into places where human rescue workers cannot or, due to high personal risks, should not enter.In this thesis project, an application is constructed with the purpose of teleoperating a simple robot. This application contains a user interface that utilizes both autonomous and semi-autonomous functions, such as search, explore and point-and-go behaviours. The purpose of the application is to work with USAR principles in a refined and simplified environment, and thereby increase the understanding for these principles and how they interact with each other. Furthermore, the thesis project reviews the recent and the current status of robots in USAR applications and use of teleoperation and semi-autonomous robots in general. Some conclusions that are drawn towards the end of the thesis are that the use of robots, especially in USAR situations, will continue to increase. As robots and support technology both become more advanced and cheaper by the day, teleoperation and semi-autonomous robots will also be seen in more and more places.
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Warler, Matthias. "Failing company defense, Sanierungsfusion und rescue merger." Baden-Baden Nomos, 2008. http://d-nb.info/989491358/04.
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Osmond, Matthew. "Eco-evolutionary rescue: an adaptive dynamic analysis." Thesis, McGill University, 2012. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=107917.
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Populations exposed to changing environments often decline in abundance and may therefore find themselves at risk of extinction. Safe abundances can be regained, and persistence secured, when populations can adapt fast enough. Here I ask how population and environmental factors determine a population's ability to persist in changing environments by adapting genetically. In Chapter 2 I investigate the response to a gradual, directional change in the environment and in Chapter 3 I investigate the response to a sudden, sustained shift. Chapter 3 also discusses the effects of interspecific competition. In both chapters I use the canonical equation of adaptive dynamics, which allows me to derive analytical expressions while including ecological process neglected in previous theory; in particular, I consider logistic population growth, frequency-dependent intraspecific competition, and interspecific competition. I use computer simulations to examine the accuracy of my analytical results when the simplifying assumptions of adaptive dynamics are relaxed. Chapter 2 derives the trait lag which maximizes the rate of evolution and also computes this maximum. Populations with higher mutational input experiencing stronger selection have the ability to adapt faster. Computer simulations show that the derived maximum rate of evolution is a good predictor of extinction across a wide range of parameter values, including those that deviate from the assumptions of adaptive dynamics. Chapter 3 first uncovers an expression for the population trait value across time and then uses this expression to calculate the time a population is below a threshold abundance, the 'time at risk'. The population trait value approaches the fitness peak quickly at first, and the rate declines exponentially. Populations with greater mutational input and maximum abundance, and those which are initially better adapted spend less time at risk. The time at risk is maximized at intermediate selection strengths, as strong selection lowers abundance and weak selection slows adaptation. Simulations show good alignment when mutations are rare and population sizes small. Interspecific competition lowers the abundance of the focal population, generally increasing the time at risk, but this can be compensated for under particular scenarios by increased selection pressure. Interspecific competition can sometimes speed adaptation and foster persistence. The ecological and evolutionary response of natural populations to environmental change depends on complex ecological interactions. Theory and experiments which include such interactions are needed for accurate descriptions of genetic adaptation to environmental change, in both the lab and in the wild.Les populations exposées à des environnements changeants déclinent souvent en abondance et peuvent ainsi être confrontées à un risque d'extinction. Des abondances suffisantes peuvent être retrouvées, ainsi qu'une persistance durable, quand les populations peuvent s'adapter suffisamment vite. Dans cette étude, je me demande comment les facteurs des populations et de l'environnement déterminent la capacité des populations à persister dans des environnements changeants grâce à une adaptation génétique. Dans le chapitre 2, j'étudie la réponse à un changement graduel et directionnel de l'environnement, et dans le chapitre 3, j'étudie la réponse à un changement soudain et soutenu. Le chapitre 3 discute également les effets de la compétition interspécifique. Dans les deux chapitres, j'utilise l'équation canonique des dynamiques adaptatives, ce qui me permet d'en dériver des expressions analytiques ainsi que d'y inclure des processus écologiques négligés dans les théories précédentes; en particulier, je considère la croissance logistique des populations, la compétition intraspécifique fréquence-dépendante, et la compétition interspécifique. J'utilise des simulations informatiques pour examiner l'exactitude de mes résultats analytiques lorsque les hypothèses simplificatrices des dynamiques sont relâchées. Le chapitre 2 dérive le retard de trait, ce qui maximise le taux d'évolution, et aussi calcule ce maximum. Les populations avec le plus grand apport de mutation rencontrant une sélection plus forte ont la capacité de s'adapter plus vite. Les simulations informatiques montrent que le taux maximal d'évolution est un bon prédicteur de l'extinction pour une large gamme de valeur de paramètres, incluant ceux qui dévient des hypothèses de dynamiques adaptatives. Le chapitre 3 dérive, tout d'abord, une expression pour la valeur de trait de population au cours du temps et, ensuite, utilise cette expression pour calculer le temps durant lequel une population se trouve sous le seuil d'abondance, le « temps du risque ». La valeur de trait de population s'approche, tout d'abord, du pic de fitness, puis le taux décline de manière exponentielle. Les populations avec un plus grand apport de mutation et une abondance maximale, et celles qui sont initialement mieux adaptées passent moins de temps dans la zone à risque. Le temps du risque est maximal à des intensités de sélection intermédiaires, puisque de fortes sélections diminuent l'abondance et de faibles sélections ralentissent l'adaptation. Les simulations montrent un bon alignement quand les mutations sont rares et les tailles des populations sont petites. La compétition interspécifique diminue l'abondance de la population focale, en accroissant généralement le temps du risque, mais cela peut être compensé pour des scénarios particuliers par un accroissement de la pression de sélection. La réponse écologique et évolutive des populations naturelles à un changement environnemental dépend de phénomènes écologiques complexes. Les théories et les expériences qui incluent de tels phénomènes sont nécessaires pour des descriptions précises de l'adaptation génétique à un changement environnemental, à la fois en laboratoire et dans la nature.
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Wang, Zhelong. "Design study of an earthquake rescue robot." Thesis, Durham University, 2004. http://etheses.dur.ac.uk/2811/.
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This thesis describes the design of a brush robot for earthquake rescue and for traversing pipes with varied cross sectional shape. Earthquake rescue is a very dangerous, difficult and challenging task, in which emergency services rescue people who are trapped in man-made structures, such as collapsed buildings after an earthquake. The building collapse may have been caused by natural or man-made events. This technology is also applicable to tunnel collapse and land slips. The focus of this work is finding the location of victims and provision of primary life support and communications. To illustrate the concept of the robot, the thesis first discusses the current development of rescue robots and pipe robots. Then the thesis focuses on the description of a brush based pipe robot, developed by the University of Durham, which would be used as the basis of an earthquake rescue robot. The concept of the robot was illustrated and compared with other current rescue robots and pipe robots. After outlining the advantages of this robot concept, a robot body shape change theory was proposed and theoretical simulations were used to verily the practicality of the robot shape change theory. The thesis also illustrates the design of the working principle and design of a robot sensor, which was subsequently used in the robot shape change experiments. The robot body shape change experiments and the experimental results are described and discussed. The experimental results illustrate the robot concept and support the robot body shape change theory. Chapter 6 focuses on the brush unit traction investigation, bristle theory and mathematical model. Furthermore, the bristle theory and mathematical model were used to explain the variation of traction force in the traction experiments.
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Gandhi, Sapan. "Molecular Mechanisms of Kinetochore Dependant Microtubule Rescue." Thesis, University of Dundee, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.500640.
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Mosesson, Yael, and Petra Nyqvist. "Tracking with search and rescue dog equipage." Thesis, Linköpings universitet, Kommunikations- och transportsystem, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-119940.
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Sjöfartsverket ansvarar för insatser när människor är i, eller befaras vara i sjönöd. För att utveckla metoderna för efterforskning av försvunna människor i sjönöd har Sjöfartsverket tillsammans med Sjöräddningssällskapet, Svenska Brukshundklubben och Myndigheten för samhällsskydd och beredskap (MSB) startat ett projekt tillsammans med räddningshundar som specialutbildats för att agera i sjömiljö, så kallade sjöräddningshundekipage. Syftet har varit att genom intervjuer och observationer ta reda på vilka sökmetoder som används för eftersök av försvunna människor på land med räddningshundar för att sedan överföra sökmetoderna så att de kan användas till sjöss för eftersök med hjälp av sjöräddningshundar. Resultatet visar att det finns ett antal olika sökmetoder för efterforskning av försvunna personer på land och den metod som används vid ett eftersök bestäms utifrån ett antal faktorer såsom väder, vind, terräng och tidsfaktorn. De sökmetoder som används vid eftersök på land är bland annat närsök, frisök, slalomsök, z-sök, parallellsök och rutsök. Författarna har, för att besvara studiens syfte följt tre steg för att överföra sökmetoder från land till sjöss. Av det som framkommit i resultatet har en jämförelse gjorts mellan förutsättningarna för sök på land och till sjöss samt att en jämförelse gjorts mellan sökmetoderna, för att visa på skillnader mellan sökmetoderna på land och till sjöss. De metoder som föreslås att utvecklas är Z-sök, slalomsök och parallellsök.
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Bamias, Christina. "Analysis of clinical trials with rescue medication." Thesis, London School of Hygiene and Tropical Medicine (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.249574.
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Stewart, M. H. "Embryo rescue for interspecific hybrids in Vicia." Thesis, University of Reading, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.383531.
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Kakisi, Ourania. "Rescue of murine gammaretroviruses in human cells." Thesis, Imperial College London, 2017. http://hdl.handle.net/10044/1/61533.
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Murine leukaemia viruses (MLVs) are simple γ-retroviruses of mice that are endogenous to the mouse genome, with several being replication-competent. In 2006, a research group using virus arrays, identified a novel MLV recombinant, XMRV, in human prostate cancer (PCa) tissue and cell lines. The virus appeared to infect and replicate efficiently in human cells. Disease associations with PCa and chronic fatigue syndrome caused a worldwide concern over the presence of XMRV in the human blood supply and patient populations. The final conclusions settled in 2011, and XMRV was widely accepted as a result of contamination in patient samples while its rescue was proven directly due to the propagation of the human cancer cell lines in nude mice in vivo. The re-emerged perception of the ability of MLVs to recombine and form novel recombinants that can infect human cells propelled the need of investigation in all cases where mouse and human cells are placed in contact for biotechnology applications in vitro, such as for the expansion of human epidermal primary stem cells prior human transplantation. We first sought to screen a variety of mouse embryonic feeder (MEF) cells that are used in human stem cell culture, for the presence of replication-competent retroviruses. To this aim, we developed a tool case of molecular assays to detect MLVs and their products and then tested various MEFs with known endogenous virus activators. We identified one stably expressed ecotropic MLV retrovirus in a CF1-MEF cell line and characterised it with molecular and infectivity assays, as well as next generation sequencing (NGS). Following, we co-cultivated human corneal stem cells with the CF1-MEF cells to test the ability of the CF1-related virus to cause human cell infection and used integration splinkerette PCR and NGS to detect possible integration site sequences in the human stem cells. In all, this study provides with a comprehensive up to date assessment over the risk of transmission of MLV viruses onto human stem cells for conditions that are comparable to the protocols used in human eye cell transplantation. We conclude that the infection of stem cells is confirmed possible by xenotropic MLVs as demonstrated for limbal eye stem cells and XMRV, but unlikely as expected for the ecotropic CF1 cell-derived virus; the possibility of recombination in mouse feeders however, cannot be excluded during prolonged co-cultivations.
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Adebola, B. A. "Corporate rescue and the Nigerian insolvency system." Thesis, University College London (University of London), 2013. http://discovery.ucl.ac.uk/1385156/.
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Foremost insolvency practitioners are agitating for the reform of the Nigerian corporate insolvency law, and in particular, its rescue system. They seek to transplant the corporate rescue model of either the United States or of England and Wales into the Nigerian insolvency system. On the premise that the present system, as well as the proposed models should be clearly understood before reforms are executed, this thesis examines the three rescue models in focus. Very little is written on the existing Nigerian rescue system. Utilising an analytical and empirical method, the thesis educes a robust and, it argues, representative picture of the Nigerian corporate rescue law and practice. It finds that the Nigerian rescue system comprises an informal and a formal phase. A company is more likely to be rescued at the informal phase, which is being developed by stakeholders to mitigate the substantive and institutional challenges that beset the formal phase. The formal rescue law is inadequate because its regimes are not fit for purpose. The greatest challenge it faces, it is argued, is administrative. Institutional failings have injected the tardiness and uncertainty that now characterise the Nigerian rescue system. The thesis proposes an analytical framework by which the rescue systems of Nigeria, the US and England and Wales, as well as other corporate rescue models, can be examined. From the analysis it presents, prospective reformers can identify the core elements of corporate rescue and how these are administered by their preferred models. They can also observe how these elements are administered by the Nigerian rescue model. It is expected that the robust findings presented in the thesis will contribute considerable value to the on-going insolvency reform debate in Nigeria.
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Meyer, K. C. (Kobus Cornelius). "Development of a GIS for sea rescue." Thesis, Stellenbosch : Stellenbosch University, 2003. http://hdl.handle.net/10019.1/53360.
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Thesis (MA)--Stellenbosch University, 2003.ENGLISH ABSTRACT: Saving the life of another person cannot be measured in monetary terms. It is also impossible to describe the satisfactiori of carrying out a successful rescue to anybody. However, the disappointment and sense of failure when a rescue mission fails and a life is lost, is devastating. Many rescue workers, including those of the National Sea Rescue Institute (NSRI), have experienced this overwhelming sense of failure. Rescue workers often dwell on failed rescue attempts, wishing that they could have arrived on the scene earlier or knew where to start looking for people. The fact that lives are still lost, despite the best efforts of rescue workers, points to the need to improve on life saving techniques, procedures, equipment and technology. Providing the NSRI with a workable tool to help them manage and allocate resources, plan a rescue, determine drift speed and distance or create search patterns, may one day be just enough to save one more life. With this goal in mind, a search and rescue application, called RescueView, was developed utilising ArcView 3.2a. This application was specifically designed for use by the NSRI, and it will be used as a command centre in all NRSI control rooms and for all rescue efforts.
AFRIKAANSE OPSOMMING: Om die lewe van 'n ander persoon te red, kan nie in geldwaarde gemeet word nie. Dit is ook onmoontlik om aan enige iemand die bevrediging van 'n suksesvolle redding te beskryf. Die terleurstelling en gevoel van verlies is egter baie groot wanneer 'n reddingspoging misluk en 'n lewe verloor word. Menige reddingswerkers, insluitend dié van die Nasional Seereddingsinstituut (NSRI), het al hierdie oorweldigende gevoel van mislukking ervaar. Reddingswerkers tob dikwels oor onsuksesvolle reddingspogings en wens dat hulle vroeër op die toneel aangekom het of geweet het waar om vir mense te begin soek. Die feit dat lewensverlies steeds plaasvind, ten spyte van reddingswerkers se beste pogings, dui op die behoefte om lewensreddingstegnieke, -prosedures, -toerusting en -tegnologie te verbeter. ( Deur die NSRI met 'n werkbare instrument te voorsien, wat hulle kan help om hulpbronne te bestuur en toe te wys, 'n redding te beplan, dryfspoed en -afstand te bepaal of soekpatrone te skep, mag eendag dalk net genoeg wees om nog 'n lewe te red. Met hierdie doel in gedagte is RescueView, 'n soek- en reddingsapplikasie, deur middel van ArcView 3.2a ontwikkel. Hierdie applikasie is spesifiek ontwerp vir gebruik deur die NSRI en dit sal as beheersentrurn in alle NSRI kontrolekamers en vir alle reddingspogings gebruik word.
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Mardell, James. "Assisting search and rescue through visual attention." Thesis, Imperial College London, 2014. http://hdl.handle.net/10044/1/24156.
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With the ubiquity of visual data being recorded, we now have the ability to view vast amounts of visual imagery. However, searching through imagery for an indeterminate target in tasks such as security baggage inspection, medical scan screening and Wilderness Search and Rescue (WiSAR), remains problematic for most people and cannot be automated. If the imagery was presented to account for the way in which humans cognitively process such visuals, then the success of these tasks might be improved. This thesis proposes and evaluates a series of presentation methods to manipulate imagery to seek this improvement. A series of user experience studies were conducted. Given the task of searching for inconspicuous 'lost' human beings in a WiSAR scenario, subjects observed multiple sequences of aerial photography embodied in six specially designed presentations. These presentations were designed following an analysis of existing visual attention literature. The first study to evaluate these methods compared the standard live (i.e. scrolling) view of the terrain to a static representation. This static portrayal of aerial search yielded an improved success rate for target location. The second method adapted the static representation, by segmenting the image into smaller tiles that were displayed for correspondingly shorter durations, while the third method enlarged the segmented tiles to fill the display. With increased segmentation, the ability for subjects to locate targets was broadly unaffected. The fourth study investigated two methods that use eye-tracking equipment to dynamically enhance the display. Contained within this thesis are the findings from these four studies, which include the analysis of each subject's performance, opinions and eye-movement behaviour. The inspiration for each presentation method was the development of a proposed model for visual search. Ultimately, the static method is revealed as the most effective for the chosen scenario of WiSAR.
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Anild, Sara, and Niklas Roos. "Image- and Video Coding for Rescue Operations." Thesis, KTH, Skolan för elektro- och systemteknik (EES), 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-199254.
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Bando, Yoshiaki. "Robust Audio Scene Analysis for Rescue Robots." Kyoto University, 2018. http://hdl.handle.net/2433/232410.
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Beck, Zoltan. "Collaborative search and rescue by autonomous robots." Thesis, University of Southampton, 2016. https://eprints.soton.ac.uk/411031/.
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In recent years, professional first responders have started to use novel technologies at the scene of disasters in order to save more lives. Increasingly, they use robots to search disaster sites. One of the most widely and successfully used robot platforms in the disaster response domain are unmanned aerial vehicles (UAVs). UAVs allow remote inspection and mapping. They are able to provide high resolution imagery and often need minimal infrastructure to fly. This allows settings where multiple UAVs are airborne accelerating the information gathering from the disaster site. However, current deployments use labour intensive, individually teleoperated UAVs. Given this, there is a drive toward using multiple robots operating with a certain level of autonomy, in order to decrease the operators' workload. One approach for utilising multiple robots in this way is semi-autonomous operation supervised by a small number of professionals; only requiring human experts for crucial decisions. Current commercial UAV platforms also allow the deployment of a diverse group of robots, allowing them to combine their individual capabilities to be more ecient. For example, xed-wing UAVs are capable of flying faster and carry larger payload, but when they do so, they should be deployed with higher safety measures (safety pilots are required for non-lightweight aircraft). On the other hand, small rotary-wing UAVs are more agile and can approach and provide imagery about objects on the ground. To this end, this thesis develops a number of new approaches for the collaboration of a heterogeneous group of robots in disaster response. More specifically, the problem of collaborative planning with robots operating in an uncertain workflow based setting is investigated by solving the search and rescue (SAR) collaboration problem. Of course, the problem complexity increases when collaborating with dierent robots. It is not different in this setting, the actions of dierent types of robots need to be planned with dependencies between their actions under uncertainty. To date, research on collaboration between multiple robots has typically focused on known settings, where the possible robot actions are dened as a set of tasks. However, in most real world settings, there is a signicant amount of uncertainty present. For ii example, information about a disaster site develops gradually during disaster relief, thus initially there is often very little certainty about the locations of people requiring assistance (e.g. damaged buildings, trapped victims, or supply shortages). Existing solutions that tackle collaboration in the face of uncertain information are typically limited to simple exploration or target search problems. Moreover, the use of generic temporal planners rapidly becomes intractable for such problems unless applied in a domain-specific manner. Finally, domain specific approaches rarely involve complex action relations, such as task dependencies where the actions of some robots are built on the actions of others. When they do so, decomposition techniques are applied to decrease the problem complexity, or simple heuristics are applied to enhance similar collaboration. Such approaches often lead to low quality solutions, because vital action dependencies across different roles are not taken into account during the optimisation. Against this background, we oer novel online planning approaches for heterogeneous multi-robot collaboration under uncertainty. First, we provide a negotiation-based bidirectional collaborative planning approach that exploits the potential in determinisation via hindsight optimisation (HOP) combined with long-term planning. Second, we extend this approach to create an anytime Monte Carlo tree search planner that also utilises HOP combined with long-term planning. In online planning settings, such as SAR, anytime planners are benecial to ensure the ability of providing a feasible plan within the given computational budget. Third, we construct a scenario close to physical deployment that allows us to show how our long-term collaborative planning outperforms the current state of the art path-planning approaches by 25 %. We conclude that long-term collaborative planning under uncertainty provides an improvement when planning in SAR settings. When combined, the contributions presented in this thesis represent an advancement in the state of the art in the eld of online planning under uncertainty. The approaches and methods presented can be applied in collaborative settings when uncertainty plays an important role for defining dependencies between partial planning problems.
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Moolla, Muhammud. "Business rescue in practice : a comparative study." Diss., University of Pretoria, 2017. http://hdl.handle.net/2263/64888.
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South Africa is experiencing constrained economic growth with a domestic growth rate for 2017, of less than one percent. This has dictated a harsh environment for South African businesses which are the back bone of the economy, providing much needed jobs. Based on international best practice, South African legislation allows an opportunity for recovery in the form of business rescue as an alternative to liquidation of the business.
Using qualitative, semi-structured interviews with an inductive approach a comparison was made between business rescue in South Africa and the parallel practice of voluntary administration in Australia. Since the inception of business rescue in South Africa, a relatively low success rate of 9.3 per cent has been achieved more especially compared to the 22 per cent success rate of voluntary administration in Australia.
Upon interrogation of the subject matter it has been established that the practices are procedurally alike however, the fundamental differences relate to the quality of business rescue practitioners and the regulatory body associated with such practitioners. This study proposes that adjustments to the standards that endorse practitioners which will lead to an improvement in the success rate of business rescue in South Africa.Mini Dissertation (MBA)--University of Pretoria, 2017.
nk2018
Gordon Institute of Business Science (GIBS)
MBA
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Alves, Pedro César Fonseca Gonçalves. "RoboCup rescue : development of inteligent cooperative agents." Master's thesis, Universidade de Aveiro, 2008. http://hdl.handle.net/10773/2047.
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Mestrado em Engenharia de Computadores e TelemáticaO trabalho desenvolvido nesta dissertação tem como tema o desenvolvimento de um agente inteligente com coordenação e comunicação no ambiente RoboCup Rescue. No RoboCup Rescue existem seis tipos de agentes, no entanto nesta tese só dois agentes foram desenvolvidos, especificamente o tipo de agentes Ambulâncias e Centros de Ambulâncias. O tipo de agente Ambulância é o elemento responsável pelo salvamento de civis na cidade virtual que constitui o ambiente RoboCup Rescue. Para cumprir essa tarefa da forma mais eficiente possível conta com coordenação e comunicação com outros agentes do mesmo tipo, e com os Centros de Ambulâncias. O comportamento da ambulância é modelado tanto para situações em que o Centro de Ambulâncias está presente durante a simulação, podendo, portanto, delegar funções para o Centro; como em situações em que o Centro não está presente, e, por isso, as ambulâncias estão encarregues de todo o processamento dos dados e de todas as tomadas de decisões. As actividades desenvolvidas pelas ambulâncias podem ser resumidas a duas: pesquisa e salvamento. Para a primeira as soluções passam muito pelo uso de algoritmos estudados em Teoria de Grafos, já que a cidade virtual é, na sua essência, um grafo, e são necessárias soluções para problemas como visitar o mapa completamente e determinar o caminho mais rápido entre dois nós. Na parte de salvamento a coordenação tem um grande papel a desempenhar.É necessário determinar que ambulâncias devem ir socorrer que civil, e quantas ambulâncias devem ajudar; ou que ambulâncias que devem continuar com a pesquisa do mapa. Ou seja, a coordenação é vital para uma utilização eficiente dos recursos disponíveis, e, consequentemente, uma boa pontuação. ABSTRACT: The work developed in this thesis has as background the development of an intelligent agent with coordination and communication in the environment of the RoboCup Rescue. RoboCup Rescue has six types of agents, however only two were developed in this thesis, specifically Ambulances and Ambulance Centers. The type of agent Ambulance is the element responsable for the rescuing of civilians in the virtual city which comprises the environment of RoboCup Rescue. To fulfill this task in the most efficient way possible it relies on coordination and communication with other agents of the same type, as well as Ambulance Centers. The behavior of an ambulance is modeled for situations when an Ambulance Center is available during the simulation, thus allowing the ambulances the possibility of dividing some of the processing and decision making; or, for situations when a center is not available and it is up to the ambulances to do make all of the decisions, and do all of the processing. The activities performed by the ambulances can be summarized in two: search, and rescue. For the first, many of the solutions may be provided by algorithms studied in Graph Theory, since the virtual city is, in its essence, a graph, and its necessary solutions to problems such as visit the city entirely, and determine the shortest path between two locations, or nodes. In the rescuing part, the coordination has a very big part to play. It is necessary to choose which ambulances should rescue a civilian, and how many should help doing it; or, which ambulances should continue searching the city for more civilians. In other words, coordination is vital for an efficient allocation of available resources, and, ultimately, a good score.
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Shaw, Michelle. "Rescue from over-indebtedness? : Christians against poverty." Thesis, Bangor University, 2015. https://research.bangor.ac.uk/portal/en/theses/rescue-from-overindebtedness-christians-against-poverty(15c3e717-ce92-46c9-9804-a9376598c655).html.
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Unmanageable personal debt creates a situation that is commonly described as “over-indebtedness.” Over-indebtedness has caused millions of people across the UK to seek advice for their situations which they feel powerless to resolve themselves. This thesis examines the work of one particular debt advice service, Christians Against Poverty (CAP) and its work through a local church, The Helpful Church. CAP provides its debt advice service through local churches so clients can experience the love of God through face to face long term advice and help. The Helpful CAP Centre (HCC) is a local CAP Centre in Derbyshire, England and is staffed by volunteers from The Helpful Church. The Helpful Church wants people to have an opportunity to experience and understand the good news (the Gospel) of the love of God which is expressed through Jesus and His Kingdom and found within the narrative of the Bible. The CAP project provides people with such an opportunity. Within the framework of Practical Theology, this thesis looks particularly at the communication of the Gospel of the Kingdom of God through the work of The Helpful CAP Centre’s debt advice service. Through empirical research methods of questionnaire and interview the impact on and response of the CAP clients to this service has been sought and evaluated. Patterns identified in the data can be used to improve delivery of debt advice through the local centre. A key recommendation is the design and use of bespoke literature which uses terminology the clients have come to understand – debt and rescue. Literature of this type could provide more opportunity for clients to understand the Gospel, thus fulfilling The Helpful Church’s aim in running the CAP project.
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Tanner, Douglas Ray. "Genetic Analysis of Ribosome Stalling and Rescue." BYU ScholarsArchive, 2009. https://scholarsarchive.byu.edu/etd/2272.
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In eubacteria, ribosome stalling on broken messenger RNA transcripts can lead to cell death. The trans-translation quality control mechanism rescues many of these stalled ribosomes. In this process, tmRNA enters stalled ribosomes by mimicking a transfer RNA, accepting the stalled nascent peptide. The ribosome then releases the broken mRNA and resumes translation on a coding region within tmRNA itself. Translation of tmRNA marks the nascent peptide for destruction by the addition of a short proteolysis tag and the ribosome is released at a stop codon within the tmRNA open reading frame. An intriguing aspect of trans-translation is that the ribosome synthesizes one protein from two RNA templates. How is the proper site chosen on tmRNA to resume translation? Do the conserved pseudoknot structures help set the reading frame? Using a genetic selection to assay libraries of tmRNA mutants, we found that stable hairpin structures can functionally replace pseudoknot 1. We conclude that the role of pseudoknot 1 in tmRNA function is purely structural. Our results demonstrate that the inactivity of an RNA mutant designed to destroy a given structure should not be interpreted as proof that the structure is necessary for RNA function. Such mutations may only destabilize a global fold that could be formed equally well by an entirely different, stable structure. Broken mRNAs are not the only cause of ribosome stalling; stalling can also result from nascent peptide interactions with the ribosomal exit tunnel that inhibit peptidyl-transferase activity. SecM, TnaC, and ErmCL all stall ribosomes to regulate the expression of downstream genes. What other peptide sequences can cause ribosome stalling? We modified our tmRNA-based selection to screen libraries of random peptides and identified a number of novel stalling peptides, including the sequence FxxYxIWPP. This sequence interacts with the exit tunnel differently than SecM and TnaC as seen in studies using mutant ribosomes. Like SecM, stalling occurs on this sequence with the next aminoacyl tRNA trapped in the A site but unable to react with the nascent peptide. These results show that a variety of peptides can interact in the exit tunnel and peptidyl-transferase center to regulate ribosome activity.
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Bosman, Justice Selvyn. "Principles of physics implicit in emergency medical rescue education and operational practice: a case study of motor vehicle related rescue." Thesis, Cape Peninsula University of Technology, 2019. http://hdl.handle.net/20.500.11838/2967.
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Thesis (Master of Emergency Medical Care (MEMC))--Cape Peninsula University of Technology, 2019Introduction: Road traffic injuries are the ninth leading cause of death globally. Projections indicate that without new and sustained commitment globally to preventing such injuries, the situation will only worsen. Motor vehicle rescue does not lend itself to the prevention of road traffic incidents but through ensuring that all incidents are managed using sound evidence could contribute in positive outcomes for victims. It is unknown what contribution rescue education makes to the body of medical rescue knowledge in South Africa. Aims: The aim of this research was to investigate the relevance and scope of the principles of physics within medical rescue specifically in the context of motor vehicle rescue. It appears that current traditional methods of presenting rescue training, which is mainly procedural and technical, may contribute to 'segmented' learning. Research Methodology: Using an interpretive research design, multiple qualitative methodologies were employed. This methodological triangulation was intended to improve construct validity and trustworthiness of findings. A modified Delphi process through which questionnaires was repeatedly distributed to rescue experts was employed. Process tracing was used to evaluate the developed typical motor vehicle rescue case scenario narrative for underpinnings of the principles of physics. The Bachelor Emergency Medical Care Physics and Extrication subject guides was evaluated for its educational alignment during the document analysis. Legitimation Code theory as a theoretical framework was utilised to appraise the knowledge gap. Results & Discussion: Motor vehicle rescue incident may not always present in a similar manner due to various factors and influences. Development of the typical motor vehicle case narrative from which its physics principles could be identified was imperative. Most motor vehicle rescue related training occur with the vehicle in the upright orientation on all four wheels. This manner of frequent training may restrict rescue practitioners from moving beyond their 'typical' training knowledge when the situation presents a typical. The thematic document analysis of the BEMC Physics and Extrication subject guides lacked the necessary coherence which is required for a professional degree. It was deemed void of certain threshold concepts and structure which would allow the student to move between the theoretical and contextual knowledge. Motor vehicle rescue subject guides and most textbooks on the topic leaned towards a procedural and very technically detailed pedagogy, to the extent that it could contribute to segmented learning. Conclusion: Developing curricula that is underpinned by a theoretically sound evidence base would promote credibility of a qualification. Curricula by design inform the teaching, learning and the competencies which would ultimately be assessed. Professional degrees are intended to develop practitioners who would graduate with the knowledge and competencies to adapt to situations. In addition, graduate attributes of lifelong learning, reflective practice and the ability to contribute to the development of new knowledge is secondary to the goal of qualification attainment.
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LaBaw, S. Marie. "Earth pressure determination in trench rescue shoring systems." College Park, Md.: University of Maryland, 2009. http://hdl.handle.net/1903/9112.
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Thesis (Ph.D.) -- University of Maryland, College Park, 2009.Thesis research directed by: Dept. of Civil and Environmental Engineering. Title from t.p. of PDF. Includes bibliographical references. Published by UMI Dissertation Services, Ann Arbor, Mich. Also available in paper.
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Hammerseth, Vegard B. "Autonomous Unmanned Aerial Vehicle In Search And Rescue." Thesis, Norges teknisk-naturvitenskapelige universitet, Institutt for teknisk kybernetikk, 2013. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-22880.
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This report presents a way of using autonomous drones to enhance search and rescue operations and takes the first steps in bringing the system to life. By using autonomous drones, less experience is required by the rescue personnel and drone specialists become excessive in this matter. Due to autonomy a drone can operate outside a valid radio link. Hence, when signal is lost, the craft can continue to search, buffer the information and send it when the link becomes active. By creating affordable drones the threshold decreases for deploying a unit in bad weather or other missions where the feedback is more important than drone return.Because the drones must sweep a large area, an aeroplane is the best suitable airframe. To generate less drag and increase stability; long, slender and thin-as-possible wings are recommended. To achieve aerodynamic stability, non-swept wings and a small positive dihedral angle is also advised. The wings should be attached on top of a slender and small-as-possible fuselage. However, due to the difficulties in landing and vulnerabilities related to this, a flying wing which obey the same design requirements, may be a better choice. A prototype for a flying wing made in expanded polypropylene was put together and tested. It proved to be resilient, able to withstand significant abuse, quickly recover to its former structure and be repaired in minutes. Highly convenient for various landing areas.An attitude and heading reference system (AHRS) is required to tell which orientation a vehicle may have. An affordable version has been realised by using micro electro mechanical sensors and a micro controller. Since the vehicle must orient itself within a search area, a NAVSTAR Global Positioning System (GPS) and way-point approach were drones are pre-programmed to follow a path has been developed together with a complete flight system.The drones search path must be programmed automatically from the given search area by the rescue personnel. This requires software and active communication link between a ground station and drones. An intuitive graphical user interface has been developed and verified to work by marking an area in the program and send coordinates over a commercial communication link to a prototype drone.A thermal imaging camera can be used to detect humans. It will make mammals stand out in an environment when viewed in the produced image (thermogram). Together with an arbitrarily threshold limit, the operators can be notified with coordinates when the threshold is reached. An experiment was carried out by placing a human at known coordinates. A drone with self position equipment was sent over the human repeatedly, automatically locating the person and reporting its location. It was concluded that the drone would be within 20 meters radius of the person.The generality and affordability of the airframe, AHRS and vision system can be useful for the university in the years ahead and the threshold for realising applications which uses any of these systems has therefore been reduced. A drone based system like this can enhance search and rescue and assist the majority by saving time, money and lives.
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Pope, Robert James Paul. "Transgenic rescue of the galanin knockout nociceptive phenotype." Thesis, University of Bristol, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.520247.
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Ang, H. C. "Biophysical characterisation and rescue of p53 cancer mutants." Thesis, University of Cambridge, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.596120.
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The aim of this thesis was to use biophysical methods to characterise the stabilities and DNA binding properties of monomeric and tetrameric p53 cancer mutants, and to study various approaches aimed at rescuing structural mutants of p53. A detailed study of the destabilising effects of p53 mutations was performed using differential scanning calorimetry and urea denaturation, while equilibrium binding of p53 mutants to a specific promoter sequence, gadd45, was studied using fluorescence anisotropy and analytical ultracentrifugation. This thesis will also discuss how p53 structural mutants may be rescued by suppressor mutations that either increase the overall protein stability of compensate specifically for oncogenically induced loss of interactions. Stability and DNA-binding measurements showed that the destabilising effects of mutations H168R and R249S were not additive, and that these mutations in combination restored DNA binding. Similar biophysical techniques were used in analysing a series of p53 core domain mutants in which the residue Ser-116 in the middle of flexible loop L1 was mutated. One mutant, S1116C, was found to be more stable than previously predicted. The crystal structure showed how the mutation had led to formation of a new hydrogen-bonding network. Altogether, these protein-engineering studies provided useful insights into possible ways to rescue p53 function. A small set of compounds was selected based on the nature of proteins and peptides that were known to interact with p53. NMR spectroscopy was used to screen for compounds binding to the protein target and to probe for atomic detail of binding interactions. It was shown that 15N-1H HSQC could be used for screening and deconvoluting mixtures of compounds, in the presence of 5% v/v d6-DMSO, at relatively high throughput.