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Journal articles on the topic 'Research hypothesis'

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Published: 4 June 2021
Last updated: 1 February 2022

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1

Binoy, Sija. "Significance of Hypothesis in Research." Indian Journal of Holistic Nursing 10, no. 01 (November 19, 2019): 31–33. http://dx.doi.org/10.24321/2348.2133.201905.

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2

Knight, Jonathan. "Hypothesis-free research." Trends in Genetics 16 (September 2000): 25. http://dx.doi.org/10.1016/s0168-9525(00)00104-9.

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3

Engert, J. C. "Unlimited Hypothesis Research." Genome Research 10, no. 3 (March 1, 2000): 271–72. http://dx.doi.org/10.1101/gr.10.3.271.

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4

LAYCOCK, GLORIA. "Hypothesis-Based Research:." Criminal Justice 1, no. 1 (February 2001): 59–82. http://dx.doi.org/10.1177/1466802501001001004.

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5

Brand, Richard A. "Hypothesis-Based Research." Journal of Orthopaedic & Sports Physical Therapy 28, no. 2 (August 1998): 71–73. http://dx.doi.org/10.2519/jospt.1998.28.2.71.

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6

Rao, UmadeviKrishnamohan. "Hypothesis-driven Research." Journal of Oral and Maxillofacial Pathology 23, no. 2 (2019): 168. http://dx.doi.org/10.4103/jomfp.jomfp_161_19.

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7

Nick, Peter. "Hypothesis-driven research for hypothesis-driven application." Protoplasma 252, no. 3 (March 27, 2015): 715–16. http://dx.doi.org/10.1007/s00709-015-0806-5.

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8

Toledo, Alexander H., Robert Flikkema, and Luis H. Toledo-Pereyra. "Developing the Research Hypothesis." Journal of Investigative Surgery 24, no. 5 (August 25, 2011): 191–94. http://dx.doi.org/10.3109/08941939.2011.609449.

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9

Shestov, Nikolay I. "Hypothesis in Political Science Research." Izvestia of Saratov University. New Series. Series: Sociology. Politology 19, no. 4 (2019): 441–47. http://dx.doi.org/10.18500/1818-9601-2019-19-4-441-447.

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10

Kaur, Simer Preet. "Writing the Hypothesis in Research." International Journal of Nursing Education 9, no. 3 (2017): 122. http://dx.doi.org/10.5958/0974-9357.2017.00081.2.

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11

Rexhep, Bujari, and Azemi Ali. "Hypothesis of the scientific research." Univerzitetska misao - casopis za nauku, kulturu i umjetnost, Novi Pazar, no. 18 (2019): 76–87. http://dx.doi.org/10.5937/univmis1918076r.

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12

白, 玉. "Hypothesis Testing in Psychological Research." Advances in Psychology 09, no. 03 (2019): 592–98. http://dx.doi.org/10.12677/ap.2019.93074.

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13

Wampold, Bruce E., Betsy Davis, and Roland H. Good. "Hypothesis validity of clinical research." Journal of Consulting and Clinical Psychology 58, no. 3 (1990): 360–67. http://dx.doi.org/10.1037/0022-006x.58.3.360.

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14

Tissot, Jean-Daniel, Pierre Farmer, Agnese Mariotti, and Curzio Rüegg. "Omics meets hypothesis-driven research." Thrombosis and Haemostasis 100, no. 05 (2008): 738–46. http://dx.doi.org/10.1160/th08-06-0348.

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SummaryThe emergence of omics technologies allowing the global analysis of a given biological or molecular system, rather than the study of its individual components,has revolutionized biomedical research, including cardiovascular medicine research in the past decade. These developments raised the prospect that classical,hypothesis-driven,single gene-based approaches may soon become obsolete. The experience accumulated so far, however, indicates that omic technologies only represent tools similar to those classically used by scientists in the past and nowadays, to make hypothesis and build models, with the main difference that they generate large amounts of unbiased information.Thus,omics and classical hypothesis-driven research are rather complementary approaches with the potential to effectively synergize to boost research in many fields, including cardiovascular medicine. In this article we discuss some general aspects of omics approaches, and review contributions in three areas of vascular biology, thrombosis and haemostasis, atherosclerosis and angiogenesis, in which omics approaches have already been applied (vasculomics).
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15

Casadevall, Arturo, and Ferric C. Fang. "Descriptive and Hypothesis-Driven Research." Microbe Magazine 4, no. 5 (May 1, 2009): 207. http://dx.doi.org/10.1128/microbe.4.207.1.

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16

Smalheiser, Neil R. "Informatics and hypothesis‐driven research." EMBO reports 3, no. 8 (August 2002): 702. http://dx.doi.org/10.1093/embo-reports/kvf164.

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17

Masinter, Alan, Mitchell Small, and Elizabeth Casman. "Research prioritization using hypothesis maps." Environment Systems and Decisions 34, no. 1 (February 19, 2014): 49–59. http://dx.doi.org/10.1007/s10669-014-9489-2.

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18

Hartwick, Jon, and Henri Barki. "Research Report—Hypothesis Testing and Hypothesis Generating Research: An Example from the User Participation Literature." Information Systems Research 5, no. 4 (December 1994): 446–49. http://dx.doi.org/10.1287/isre.5.4.446.

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19

Misra, Durga Prasanna, and Vikas Agarwal. "GENERATING WORKING HYPOTHESES FOR ORIGINAL RESEARCH STUDIES." Central Asian Journal of Medical Hypotheses and Ethics 1, no. 1 (August 7, 2020): 14–19. http://dx.doi.org/10.47316/cajmhe.2020.1.1.02.

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A hypothesis is a statement of the expected outcome of a research study, generally based on analysis of prior published knowledge, or with reference to the previous work of the investigators. The hypothesis forms the foundation of a research proposal. A study based, and planned, on a sound hypothesis may have a greater likelihood of meaningfully contributing to science. After the generation of a hypothesis, it is equally important to appropriately design and adequately power a study (by ensuring a sufficient sample size) in order to test the hypothesis. Adhering to principles discussed forthwith shall help young researchers to generate and test their own hypotheses, and these are best learnt with experience.
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20

Haas, Oskar A., and Marieke Seyger. "Hypothesis." Cancer Genetics and Cytogenetics 70, no. 2 (October 1993): 112–16. http://dx.doi.org/10.1016/0165-4608(93)90178-o.

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21

Wang, Jun. "Progress of Research in the Action Mechanism of Grain Growth Inhibitor for Cemented Carbide." Advanced Materials Research 997 (August 2014): 356–58. http://dx.doi.org/10.4028/www.scientific.net/amr.997.356.

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Three hypotheses for the grain growth inhibiting mechanism of carbide grain were described in this paper: the dissolution hypothesis, the adsorption hypothesis and the segregation hypothesis. The weakness of these three existing hypotheses has been pointed out. On the basis of analyzing the existing research results of other researchers, this paper proposed a new grain growth inhibiting mechanism: segregation - dissolution hypothesis.
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22

Viganò, Paola. "The Modern Project: A Research Hypothesis." Urban Planning 4, no. 3 (September 30, 2019): 83–89. http://dx.doi.org/10.17645/up.v4i3.2485.

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The project of the industrial modern city comprises many heterogeneous paths and stories, in particular those regarding the CIAM (Congrès Internationaux d’Architecture Moderne) Functional City. They all come together in a discourse that links the architectural form to positive urban and social transformations. Such a discourse was interpreted from two different perspectives: The first hypothesized the need for political change starting from the collectivization of land ownership as stressed in the declaration of CIAM at La Sarraz in 1928, whereas the second theorised the capacity of new architecture to improve living conditions irrespective of the political context as supported by Le Corbusier. Starting from these premises, the present commentary proposes a fresh perspective on the functional city project, where the research on the minimization of effort contributed to a different definition of work from the Marxist one and in the modern sense. Therefore, the design and the space of the Existenzminimum blatantly contributes to the construction of a new routine, inspired by minimum effort, with the creation of a new effort–relaxation–rest rhythm and repetition.
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23

INDAHL, A. "Hypothesis for research or for treatments?" Acta Anaesthesiologica Scandinavica 57, no. 3 (February 6, 2013): 269–70. http://dx.doi.org/10.1111/aas.12066.

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24

Biesecker, L. G. "Hypothesis-generating research and predictive medicine." Genome Research 23, no. 7 (July 1, 2013): 1051–53. http://dx.doi.org/10.1101/gr.157826.113.

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25

Gilgun, Jane F. "Hypothesis Generation in Social Work Research." Journal of Social Service Research 15, no. 3-4 (June 8, 1992): 113–35. http://dx.doi.org/10.1300/j079v15n03_07.

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26

Lansley, Peter. "Research assessment and the activity hypothesis." Engineering, Construction and Architectural Management 20, no. 1 (January 4, 2013): 7–28. http://dx.doi.org/10.1108/09699981311288655.

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27

Alger, Bradley E. "Scientific Hypothesis-Testing Strengthens Neuroscience Research." eneuro 7, no. 4 (July 2020): ENEURO.0357–19.2020. http://dx.doi.org/10.1523/eneuro.0357-19.2020.

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28

Yu, Huai-zhong, Xiang-chu Yin, Meng-fen Xia, Zhao-yong Xu, Min Li, Nai-gang Liang, Ke-yin Peng, et al. "Experimental research on critical point hypothesis." Acta Seismologica Sinica 17, S1 (November 2004): 129–37. http://dx.doi.org/10.1007/s11589-004-0076-3.

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29

Jialin, Wang. "Research Prospect of Intergroup Contact Hypothesis." Psychology of China 3, no. 2 (2021): 177–84. http://dx.doi.org/10.35534/pc.0302022.

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30

Feldkamp, Marcia L., John C. Carey, and Thomas W. Sadler. "Development of gastroschisis: Review of hypotheses, a novel hypothesis, and implications for research." American Journal of Medical Genetics Part A 143A, no. 7 (2007): 639–52. http://dx.doi.org/10.1002/ajmg.a.31578.

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31

De LAND, PAUL N., and WALTER Wm CHASE. "Entry III.A: Statistical Hypotheses, Null vs. Alternative; Entry III.B; Statistical vs. Research Hypothesis." Optometry and Vision Science 68, no. 7 (July 1991): 565–68. http://dx.doi.org/10.1097/00006324-199107000-00011.

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32

Azimi, Arsalan, and Arian Azimi. "Hypothesis." Anti-Cancer Drugs 28, no. 4 (April 2017): 369–75. http://dx.doi.org/10.1097/cad.0000000000000476.

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33

Rowbottom, Darrell P., and R. McNeill Alexander. "The Role of Hypotheses in Biomechanical Research." Science in Context 25, no. 2 (April 24, 2012): 247–62. http://dx.doi.org/10.1017/s0269889712000051.

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ArgumentThis paper investigates whether there is a discrepancy between stated and actual aims in biomechanical research, particularly with respect to hypothesis testing. We present an analysis of one hundred papers recently published in The Journal of Experimental Biology and Journal of Biomechanics, and examine the prevalence of papers which (a) have hypothesis testing as a stated aim, (b) contain hypothesis testing claims that appear to be purely presentational (i.e. which seem not to have influenced the actual study), and (c) have exploration as a stated aim. We found that whereas no papers had exploration as a stated aim, 58 per cent of papers had hypothesis testing as a stated aim. We had strong suspicions, at the bare minimum, that presentational hypotheses were present in 31 per cent of the papers in this latter group.
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34

Balmain, Allan. "Working Hypothesis." Molecular Carcinogenesis 2, no. 6 (1989): 303–4. http://dx.doi.org/10.1002/mc.2940020603.

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35

Edward, John T. "Wartime research on RDX: A false hypothesis is better than no hypothesis." Journal of Chemical Education 64, no. 7 (July 1987): 599. http://dx.doi.org/10.1021/ed064p599.

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36

Sabbour, Ali. "How to design and conduct research? – Research question & hypothesis." Ain Shams Journal of Surgery 2, no. 1 (January 1, 2008): 1–3. http://dx.doi.org/10.21608/asjs.2008.176998.

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37

Kuroda, Masao. "Hypothesis on Enhancement of Research Group Activity." Japan journal of water pollution research 13, no. 9 (1990): 545. http://dx.doi.org/10.2965/jswe1978.13.545.

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38

Kelly, Katherine Patterson, Kimberly Pyke-Grimm, Janet L. Stewart, and Pamela S. Hinds. "Hypothesis Generation for Childhood Cancer Communication Research." Western Journal of Nursing Research 36, no. 4 (October 23, 2013): 512–33. http://dx.doi.org/10.1177/0193945913507487.

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39

Lybeck, Johan A. "Research Note:Is the Lipset-Rokkan Hypothesis Testable?" Scandinavian Political Studies 8, no. 1-2 (June 1985): 105–13. http://dx.doi.org/10.1111/j.1467-9477.1985.tb00314.x.

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40

Fandella, A., S. De Angeli, and G. Anselmo. "Etiopathogenesis: Hypothesis and Confirmation of Experimental Research." Urologia Journal 61, no. 3 (June 1994): 179–83. http://dx.doi.org/10.1177/039156039406100303.

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After a review of the latest points of view about the etiopathogenesis of prostatic hyperplasia; i.e. hormonal growth factors, McNeal's theory of reawakening, theories based on the involvement of staminal cells, and the correlation between BPH and prostatic cancer, the authors report their practical experience on this subject. Since 1989 they have prepared in-vitro cultures, standardized the methodology and obtained an “immortalized” cell clone named U285. These cells have been cultivated with different concentrations of testosterone and growth factors. Analyses were performed by direct observation, providing cytologic and immunochemical preparations for morphologic characterization, and using the Frame cytotoxity test to determine the proliferative index. From a preliminary survey of results it seems that the DHT does not affect multiplication of the cells, but takes part in the differentiation process, becoming an agent of well-being and not a real growth factor. The EGF would appear to be efficacious only at high dosage with non differentiation and growth of immature cells. Suramine, a growth factor antagonist, and Finasteride, an inhibitor of the 5 alpha reductase enzyme, were utilized to explain the micro-endocrinology mechanisms at the origin of these processes.
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41

Büttner, Fionn, Elaine Toomey, Shane McClean, Mark Roe, and Eamonn Delahunt. "Are questionable research practices facilitating new discoveries in sport and exercise medicine? The proportion of supported hypotheses is implausibly high." British Journal of Sports Medicine 54, no. 22 (July 22, 2020): 1365–71. http://dx.doi.org/10.1136/bjsports-2019-101863.

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Questionable research practices (QRPs) are intentional and unintentional practices that can occur when designing, conducting, analysing, and reporting research, producing biased study results. Sport and exercise medicine (SEM) research is vulnerable to the same QRPs that pervade the biomedical and psychological sciences, producing false-positive results and inflated effect sizes. Approximately 90% of biomedical research reports supported study hypotheses, provoking suspicion about the field-wide presence of systematic biases to facilitate study findings that confirm researchers’ expectations. In this education review, we introduce three common QRPs (ie, HARKing, P-hacking and Cherry-picking), perform a cross-sectional study to assess the proportion of original SEM research that reports supported study hypotheses, and draw attention to existing solutions and resources to overcome QRPs that manifest in exploratory research. We hypothesised that ≥ 85% of original SEM research studies would report supported study hypotheses. Two independent assessors systematically identified, screened, included, and extracted study data from original research articles published between 1 January 2019 and 31 May 2019 in the British Journal of Sports Medicine, Sports Medicine, the American Journal of Sports Medicine, and the Journal of Orthopaedic & Sports Physical Therapy. We extracted data relating to whether studies reported that the primary hypothesis was supported or rejected by the results. Study hypotheses, methodologies, and analysis plans were preregistered at the Open Science Framework. One hundred and twenty-nine original research studies reported at least one study hypothesis, of which 106 (82.2%) reported hypotheses that were supported by study results. Of 106 studies reporting that primary hypotheses were supported by study results, 75 (70.8%) studies reported that the primary hypothesis was fully supported by study results. The primary study hypothesis was partially supported by study results in 28 (26.4%) studies. We detail open science practices and resources that aim to safe-guard against QRPs that bely the credibility and replicability of original research findings.
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42

Riley, P. A. "THE MELATONIN HYPOTHESIS." Melanoma Research 8, no. 2 (April 1998): 194. http://dx.doi.org/10.1097/00008390-199804000-00017.

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43

La Vecchia, Carlo. "Hypothesis." European Journal of Cancer Prevention 20, no. 6 (November 2011): 556. http://dx.doi.org/10.1097/cej.0b013e32834a8018.

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44

Powell, Jonathan M., Emanuel Ebin, Steven Borzak, Anastasios Lymperopoulos, and Charles H. Hennekens. "Hypothesis." Journal of Cardiovascular Pharmacology and Therapeutics 22, no. 1 (July 8, 2016): 51–53. http://dx.doi.org/10.1177/1074248416644350.

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The hypothesis that paroxetine decreases morbidity and mortality in patients with heart failure (HF) is plausible but unproven. Basic research demonstrates that inhibition of G protein-coupled receptor kinase 2 (GRK2) both in vitro and in vivo in the myocardium may be beneficial. G protein-coupled receptor kinase 2 antagonism is purported to exert cardioprotective effects immediately following myocardial injury by blunting toxic overstimulation on a recently injured heart. In addition, chronic overexpression of GRK2 inhibits catecholamine induction of vital positive chronotropic and ionotropic effects required to preserve cardiac output leading to worsening of congestive HF. In cardiac-specific GRK2 conditional knockout mice, there is significant improvement in left ventricular wall thickness, left ventricular end-diastolic diameter (LVEDD), and ejection fraction (EF) compared to controls. Paroxetine is a selective serotonin reuptake inhibitor which was recently shown to have the ability to directly inhibit GRK2 both in vitro and in vivo. At physiologic temperatures, paroxetine inhibits GRK2-dependent phosphorylation of an activated G-protein-coupled receptor with a half maximal inhibitory concentration of 35 micromoles, a substantially greater affinity than for other G protein-coupled receptor kinases. In a randomized trial in mice with systolic HF and depressed EF postmyocardial infarction, those treated with paroxetine had a 30% increase in EF, improved contractility, and LVEDD and wall thickness compared to those treated with medical therapy alone. While further basic research may continue to elucidate plausible mechanisms of benefit and observational studies will contribute important relevant information, large scale randomized trials designed a priori to do so are necessary to test the hypothesis.
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45

Tančić, Dragan, and Dalibor Elezović. "Hypotheses in historical research." Bastina, no. 53 (2021): 161–73. http://dx.doi.org/10.5937/bastina31-31917.

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In all sciences, there is a general agreement that hypotheses can be defined under the rules of scientific defining. Consequently, with most authors in different sciences and scientific disciplines, it is indisputable that there is a general agreement of different theoretical and methodological directions that hypotheses are based on assumptions about the phenomenon, problem, and subject of research, which are expressed in the form of attitudes and judgments and have some cognitive value, in all sciences as well as in historical research. Hypotheses are determined by the definition of the problem, the subject of the research, and the goals of the research, primarily scientific ones. Hypotheses in all sciences, even historical ones, consist of variables and attitudes of a hypothesis that expresses the relations between variables. It is necessary to distinguish hypotheses in the process of acquiring scientific knowledge and in scientific research projects.
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46

Cairo, Athena H., Jeffrey D. Green, Donelson R. Forsyth, Anna Maria C. Behler, and Tarah L. Raldiris. "Gray (Literature) Matters: Evidence of Selective Hypothesis Reporting in Social Psychological Research." Personality and Social Psychology Bulletin 46, no. 9 (February 24, 2020): 1344–62. http://dx.doi.org/10.1177/0146167220903896.

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Selective reporting practices (SRPs)—adding, dropping, or altering study elements when preparing reports for publication—are thought to increase false positives in scientific research. Yet analyses of SRPs have been limited to self-reports or analyses of pre-registered and published studies. To assess SRPs in social psychological research more broadly, we compared doctoral dissertations defended between 1999 and 2017 with the publications based on those dissertations. Selective reporting occurred in nearly 50% of studies. Fully supported dissertation hypotheses were 3 times more likely to be published than unsupported hypotheses, while unsupported hypotheses were nearly 4 times more likely to be dropped from publications. Few hypotheses were found to be altered or added post hoc. Dissertation studies with fewer supported hypotheses were more likely to remove participants or measures from publications. Selective hypothesis reporting and dropped measures significantly predicted greater hypothesis support in published studies, supporting concerns that SRPs may increase Type 1 error risk.
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47

Freireich, Emil J., Razelle Kurzrock, and Zeev Estrov. "Metastasis-An alternative hypothesis." Cancer 103, no. 8 (2005): 1537–39. http://dx.doi.org/10.1002/cncr.20935.

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48

Ewing, David. "The Oxygen Fixation Hypothesis." American Journal of Clinical Oncology 21, no. 4 (August 1998): 355–61. http://dx.doi.org/10.1097/00000421-199808000-00008.

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49

Sarmukaddam, SanjeevB. "Interpreting "statistical hypothesis testing" results in clinical research." Journal of Ayurveda and Integrative Medicine 3, no. 2 (2012): 65. http://dx.doi.org/10.4103/0975-9476.96518.

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50

Winkler, F. G., and J. Fürnkranz. "A Hypothesis on the Divergence of AI Research." ICGA Journal 21, no. 1 (March 1, 1998): 3–13. http://dx.doi.org/10.3233/icg-1998-21102.

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