Academic literature on the topic 'Research report, annual report, institut of physics'

A workshop was held at MIT in February 1986 for specialists performing theoretical research on the interactions of water waves with floating or submerged bodies. The principal applications of this field are related to ship hydrodynamics and to wave loadings on offshore platform. In addition to the traditional approach based on linearization of the wave and body motions, substantial progress has been made on nonlinear problems including both analytical and numerical studies. Subsequent workshops are planned on an annual basis.

The NanoTech Poland is an annual international conference with a strong scientific agenda focused on nanotechnology in energy, environment, and biomedicine. The Nanotech Poland 2018 was held at the NanoBioMedical Centre and Department of Physics at Adam Mickiewicz University in Poznań from June 6th to June 9th. The aim of NanoTech Poland 2018 was to bring together the scientific community’s principal investigators, scientists, researchers, analysts, clinicians, policy makers, industry experts, and well-established and budding entrepreneurs to discuss the present and future perspectives in nanotechnology and nanoscience research and development. This year, the 1st Symposium on Polydopamine was held on June 6th. This forum was dedicated to the application of polydopamine and related catechol materials in a variety of research fields, both at the nano- and macroscale. The symposium gathered leading scientists from this important research field from top universities and institutions that have been involved in the research revolved around polydopamine. With over 200 national and international participants, NanoTech Poland 2018 and the 1st Symposium on Polydopamine provided a forum to present and discuss the latest scientific news from the field of nanotechnology with a strong interdisciplinary aspect and bioinspired materials.

Bioclimatology is applied for growing tea in the West of Nghe An province, where the tea is considered as a high economic efficient plant to be priorly cultivated for reducing poverty and getting rich. Based on the bioclimatic characteristics of tea plant and regional climatic data from 1980 to 2014, the bioclimatic diagrams are built and the tea cultivability is mapped in term of annual average temperature and total precipitation, for this region with regarding its district of Con Cuong as an analytical key. The climate, including both temperature and precipitation, in Con Cuong is relatively suitable for the tea plantation. The Western Nghe An, a land of approx. 1.4 million ha, could be classified in five areas with different suitability for tea plant. The unfavorable area occupies only 1% of total region and the four favorable rests account for 99% of total, in which, the most favorable area is largest with about 746,355 ha, i.e. over 50% of whole region. The three other areas are cultivable but they are less favorable in terms of either temperature or precipitation. Growing tea in Western Nghe An, even in favorable areas, it should be taken into account of the weather disadvantages in certain moments of the year such as extreme dry, cold, hot and rainy events.ReferencesAhmed S., 2014. Tea and the taste of climate change, www.herbalgram.org, issue, 103, 44–51.Ahmed S., Stepp J.R., Orians C., Griffin T., Matyas C., 2014. Effects of extreme climate events on tea (Camellia sinensis) functional quality validate indigenous farmer knowledge and sensory preferences in tropical China. PloS one, 9(10), e109126.Bhagat R.M., Deb Baruah R., Safique S., 2010. climate and tea [camellia sinensis (l.) o. kuntze] Production with Special Reference to North Eastern India: A Review. Journal of Environmental Research And Development, 4(4), 1017–1028.Carr M., 1972. The Climatic Requirements of the Tea Plant: A Review. Experimental Agriculture, 8(01), 1–14. https://doi.org/10.1017/S0014479700023449.Carr M.K.V., Stephen W., 1992. Climate, weather and the yield of tea. In: Tea Cultivation to consumtpion. K.C. Wilson and M.N. Clifford (Eds). Chapman and Hall, 87–135.Daleen Lotter, David le Maitre, 2014. Modeling the distribution of Aspalathus linearis (Rooibos tea): implications of climate change for livelihoods dependent on both cultivation and harvesting from the wild. Ecology and Evolution, 4(8), 1209–1221.Ducan J.M.A., Saikia S.D., Gupta N., Biggs E.M., 2016. Observing climate impacts on tea yield in Assam, India. Applied Geogr., 77, 64–71.Institute of Geography, 2016. Department of Climatically Geography. The precipitation and temperature data at meteorological measuring stations in the West of Nghe An Province between 1984 and 2014. Data stored at Department of Climatically Geography, Institute of Geography, Ha Noi, 46p.Gaussen H., 1954. 8 ème Congrès international de Botanique. Section 7 et 3. Paris.Hadfield W., 1976. The effect of high temperature on some aspects of the physiology and cultivation of tea bush (Camellia sinensis) in North East India. In: Light as an Ecological factor. G.C. Evans, R. Bainbridge and O. Rackham (Eds.) Blackwel Sci. Publ., London, 477–495.Hoang Luu Thu Thuy, 2012. The comprehensive assessment of natural, socio-economic and environmental conditions for environmental protection planning in Nghe An Province. Doctoral Thesis. Institude of Geography, Hanoi, 150p.Huang Shoubo, 1989. Meteorology of tea plants in China: a review. Agri. Forest Meteorol., 47, 19–30.Huang Shoubo, 1991. A study on the ecological climates of some famous tea growing areas in high mountainous regions of China. Chinese Geographical Science, 1(2), 121–128.International Center for Tropical Agriculture, 2017. Identification of suitable tea growing areas in Malawi under climate change scenarios. Ciat report, Cali, Colombia, 39p.Kabir S.E., 2001. A study on Ecophysiology of Tea (Camellia sinensis) with special reference to the influence of climatic factors on physiology of a few selected Tea clones of Darjeering. International Journal of Tea Science, 1(4), 1–9.Kandiah S., Thevadasan T., 1980. Quantification of weather parameters to predict tea yields. Tea Q., Srilanka, 49(1), 25–33.Kaye L., 2014. Climate change threatens Sri Lanka’s tea industry. Triple Pundit: People, Planet, Profit. Available at: www.triplepundit.com/2014/06/climate-changethreatens-sri-lanka-tea-industry. Accessed July 25, 2014.Nakayama A., Harada S., 1962. Studies on the effect on the growth of tea plant. IV. The effect of temperature on the growth of young plants in summer. Bull. Tea Res. Station, Japan, 1, 28–40.Nguyen Bao Ve, 2005. The syllabus of industrial trees. Hanoi Argricultural Publishing House, 224p.Nguyen Dai Khanh, 2003. The assessment of agricultural climatic conditions for tea’s growth in major tea regions of Vietnam. Doctoral Thesis. Institute of Meteorology and Hydrology, 149p.Nguyen Khanh Van, Nguyen Thi Hien, Phan Ke Loc, Nguyen Tien Hiep, 2000. The bioclimatic diagrams of Vietnam. Vietnam National University Publishing House, Ha Noi, 126p.Nguyen Van Hong, 2017. Analyzing, assessing landscape for agriculture, forestry development and biodiversity conservation in the southwestern border districts in Nghe An province. Doctoral thesis. Vietnam National University, Hanoi, 150p.Nguyen Van Tao (ed.), 2004. Completing the asexual propagation process of LDP1 and LDP2 cultivars by cuttings in order to transfer to production. State Project of production pilot, coded KC.06.DA.09.NN. Institute of Tea Research, Phu Tho, 50p.Nkomwa E.C., Joshua M.K., Ngongondo C., Monjerezi M., Chipungu F., 2014. Assessing indigenous knowledge systems and climate change adaptation strategies in agriculture: A case study of Chagaka Village, Chikhwawa, Southern Malawi. Physics and Chemistry of the Earth, Parts A/B/C, 67–69, 164–172.Pham Hoang Ho, 2003. An Illustrated Flora of Vietnam, 2, 430–434. Youth Publishing House, 952p.Rebecca Boehm, Sean B. Cash, Bruce T. Anderson, Selena Ahmed, Timothy S. Griffin, Albert Robbat Jr., John Richard Stepp, Wenyan Han, Matt Hazel and Colin M. Orians, 2016. Association between Empirically Estimated Monsoon Dynamics and Other Weather Factors and Historical Tea Yields in China: Results from a Yield Response Model. Climate, 4, 20; doi:10.3390/cli4020020. www.mdpi.com/journal/climate.Schepp K., 2014. Strategy to adapt to climate change for Michimikuru tea farmers in Kenya. Adap CC Report. 2008. Available at: www.adapcc.org/en/kenya.htm. Accessed July 25, 2014.Sen A.R., Biswas A.K., Sanyal D.K., 1966. The Influence of Climatic Factors on the Yield of Tea in the Assam Valley, J. App. Meteo., 5(6), 789–800.Statistics Office of Nghe An Province, 2016. The annual abstracts of statistics 2015. Nghe An Publishing House, Nghe An, 453p.Tanton T.W., 1982. Environmental factors affecting yield of tea (camellia sinensis). Effect of air temperature. Expl. Agri., 18, 47–52.The People’s Committee of Nghe An Province, 2013. The Decision No. 448/QĐ-UBND dated 31/01/2013 to approve the hi-tech agriculture planning on the production of tea in Nghe An Province.The People’s Committee of Nghe An Province, 2013. The Decision No. 6290/QĐ-UBND dated 24/12/2013 to approve the adjustments and supplements for the development of Nghe An tea Industrial zone planning in 2013–2020.Walter H, Lieth, 1967. Klimadiagram - Weltatlas. Veb Gustav Fischer Verlag Jena.Wijeratne M.A., 1996. Vulnerability of Sri Lanka tea production to global climate change. Water, Air and Soil Pollution, 92(1-2), 87–94.Wijeratne M.A., Anandacoomaraswamy A., Amarathunga M., Ratnasiri J., 2007. Assessment of impact of climate change on productivity of tea (Camellia sinensis L.) plantations in Sri Lanka, 119–126.http://nghean.gov.vn, 05/06/2015. Many crops are withered in Con Cuong.http://baonghean.vn, 25/03/2013. Drought threaten rice and tea in Con Cuong. http://baonghean.vn/con-cuong-han-han-de-doa-lua-che-44581.html.

ABSTRACT Aim Medico-Ethno Botanical Survey (MEBS) was initiated by the Central Council for Research in Ayurvedic Sciences (CCRAS) in 1969 with the main aim of survey and documentation of medicinal plants of India used in Ayurveda system of medicine. Through its five peripheral institutes, namely Regional Ayurveda Research Institute for Metabolic Disorders (RARIMD)— Bengaluru, Regional Ayurveda Research Institute for Gastro-Intestinal Disorders (RARIGID)—Guwahati, Regional Ayurveda Research Institute (RARI)—Itanagar, RARI—Jhansi, and RARI—Ranikhet, the Council has surveyed every part of phytogeographic regions across the country, including the Andaman & Nicobar Islands and Lakshadweep. During these survey tours, various medicinal plants were collected and preserved as Herbarium and Museum specimens. The survey team collects and supplies authentic raw drug samples for studies under various projects inside and outside the Council, including the projects under Central Scheme of Ayurvedic Pharmacopoeia Committee (APC). Herbarium and Museum centers located in various institutes of CCRAS are being used as reference centers for UG/PG/M.Phil./Ph.D. students and researchers for correct identification/authentication of their plant specimens or raw drug materials. Further, the folk-claims collected during the exploration work provide lead for validation and effective development of drugs based on traditional knowledge and not from any codified system of medicine. Ayurvedic ancient texts also explain the importance of medicinal plant survey. Materials and methods The gross physical achievements including the beneficiaries of MEBS, details of forest divisions, medicinal plant species collected, and preparation of Herbarium specimens during the reporting period 1969 to 2016 were compiled, summarized, and presented based on the information available in the published monographs, technical reports, and annual reports of CCRAS. Conclusion India is rich in its diverse natural resources and treated as one of the biggest natural biodiversity countries of the world. The cultural diversity in the country is represented by many cultural groups, including the tribes and others. The contributions of CCRAS are significant in extending Medico-Ethno Botanical Program across the country and also preserving the valuable ethnomedical knowledge prevailing among tribal communities through systematic survey, identification, preservation, documentation, and validation of medicinal plants. How to cite this article Rath C, Susmitha B, Tripathi AK, Chincholikar MB, Mangal AK, Srikanth N. Medico-Ethno Botanical Survey: An Overview of CCRAS Contributions. J Drug Res Ayurvedic Sci 2017;2(3):188-240.

One of the most important competitive advantages of researchers / research organizations is their individual visibility in professional community depending on scientific importance of results obtained. Under hard competitive conditions, however, not only results as such are essentially important for the visibility but also the amount of publications reflecting them. This amount depends, amongst other factors, on scholarly journals’ publication speeds. In Russia, an annual amount of publications accounted in the WoS / Scopus is adapted as the main criterion for institutes of the RAS on the state task fulfillment, thus making the speed of research results publishing critically important. The article reflects the results of the statistical analysis of publication speeds of materials for the authors affiliated with the Boreskov Institute of Catalysis (BIC), Siberian Branch of the RAS. The statistical analysis of journal publication speeds is performed with the aid of the CRIS-system SciAct. The system embraces more than 20 modes of scientific activities and accounts journal articles, conferences proceedings, patents, dissertations, etc. It contains profiles of authors, organizations and journals and allows preparing various reports and accounts in one click. With array of more than 8 thousands of BIC articles 1960–2019 in 712 scholarly journals, the authors determined the minimal, maximal and median values of their publication speeds. Results obtained allow recommending journals with median articles’ publication speed of 1–2 months to the staff of physical-chemical research organizations. The approach and its results are useful for research planning.

BackgroundAnorexia nervosa (AN) is a severe psychiatric condition and evidence on how to best treat it is limited.ObjectivesThis programme consists of seven integrated work packages (WPs) and aims to develop and test disseminable and cost-effective treatments to optimise management for people with AN across all stages of illness.MethodsWP1a used surveys, focus groups and a pre–post trial to develop and evaluate a training programme for school staff on eating disorders (EDs). WP1b used a randomised controlled trial (RCT) [International Standard Randomised Controlled Trial Number (ISRCTN) 42594993] to evaluate a prevention programme for EDs in schools. WP2a evaluated an inpatient treatment for AN using case reports, interviews and a quasi-experimental trial. WP2b used a RCT (ISRCTN67720902) to evaluate two outpatient psychological therapies for AN. WP3 used a RCT (ISRCTN06149665) to evaluate an intervention for carers of inpatients with AN. WP4 used actimetry, self-report and endocrine assessment to examine physical activity (PA) in AN. WP5 conducted a RCT (ISRCTN18274621) of an e-mail-guided relapse prevention programme for inpatients with AN. WP6 analysed cohort data to examine the effects of maternal EDs on fertility and their children’s diet and growth. WP7a examined clinical case notes to explore how access to specialist ED services affects care pathways and user experiences. Finally, WP7b used data from this programme and the British Cohort Study (1970) to identify the costs of services used by people with AN and to estimate annual costs of AN for England.ResultsWP1a: a brief training programme improved knowledge, attitudes and confidence of school staff in managing EDs in school. WP1b: a teacher-delivered intervention was feasible and improved risk factors for EDs in adolescent girls. WP2a: both psychological therapies improved outcomes in outpatients with AN similarly, but patients preferred one of the treatments. WP2b: the inpatient treatment (Cognitive Remediation and Emotional Skills Training) was acceptable with perceived benefits by patients, but showed no benefits compared with treatment as usual (TAU). WP3: compared with TAU, the carer intervention improved a range of patient and carer outcomes, including carer burden and patient ED symptomatology. WP4: drive to exercise is tied to ED pathology and a desire to improve mood in AN patients. PA was not increased in these patients. WP5: compared with TAU, the e-mail-guided relapse prevention programme resulted in higher body mass index and lower distress in patients at 12 months after discharge. WP6: women with an ED had impaired fertility and their children had altered dietary and growth patterns compared with the children of women without an ED. WP7a: direct access to specialist ED services was associated with higher referral rates, lower admission rates, greater consistency of care and user satisfaction. WP7b: the annual costs of AN in England are estimated at between £45M and £230M for 2011.ConclusionsThis programme has produced evidence to inform future intervention development and has developed interventions that can be disseminated to improve outcomes for individuals with AN. Directions for future research include RCTs with longer-term outcomes and sufficient power to examine mediators and moderators of change.Trial registrationCurrent Controlled Trials ISRCTN42594993, ISRCTN67720902, ISRCTN06149665 and ISRCTN18274621.FundingThis project was funded by the National Institute for Health Research (NIHR) Programme Grants for Applied Research programme and will be published in full inProgramme Grants for Applied Research; Vol. 5, No. 16. See the NIHR Journals Library website for further project information.

Abstract Objectives Morbidity and mortality from cardiovascular diseases (CVDs) are higher among individuals with a lower, compared to those with a higher socioeconomic position (SEP). However, the contribution of modifiable risk factors to these inequities is not known. This study aimed to examine whether and to what extent modifiable risk factors mediate associations between SEP and CVD morbidity and mortality in a nationally representative sample of Canadian adults. Methods We used a population-based prospective observational cohort design whereby participants who completed the Canadian Community Health Survey (2000–2011; n = 289,800) were followed longitudinally for CVD morbidity and mortality using administrative health and mortality data in the Discharge Abstract Database and the Canadian Mortality Database until 31 March 2013. Participants were included if they were at least 35 years of age and did not self-report CVD at the time of survey administration. The exposure of interest was SEP, which was measured as a latent variable consisting of annual household income and educational attainment. Potential mediators included smoking, physical inactivity, obesity, diabetes, and hypertension. The primary outcome of interest was CVD morbidity and mortality, which was defined as the first fatal or nonfatal CVD event that occurred during follow-up (6.2 years). Generalized structural equation modeling was used to test the mediating effects of modifiable risk factors in associations between SEP and CVD morbidity and mortality. Results SEP was associated with CVD morbidity and mortality. Modifiable risk factors mediated 80% of associations between SEP and CVD morbidity and mortality. Smoking was the most important mediator of these associations. Obesity mediated associations between SEP and CVD individually and jointly with diabetes or hypertension. Conclusions These findings point to modifiable risk factors as potential targets for interventions to reduce inequities in CVD morbidity and mortality. Knowledge of pathways linking SEP with CVD is essential to inform targeted interventions to reduce socioeconomic inequities in CVD morbidity and mortality. Funding Sources This study was funded by a Libin Cardiovascular Research Institute of Alberta Innovation Seed Grant and the Petro-Canada Young Innovator Award in Community Health.

Climate change induced sea-level rise (SLR) is on its increase globally. Regionally the lowlands of China, Vietnam, Bangladesh, and islands of the Malaysian, Indonesian and Philippine archipelagos are among the world’s most threatened regions. Sea-level rise has major impacts on the ecosystems and society. It threatens coastal populations, economic activities, and fragile ecosystems as mangroves, coastal salt-marches and wetlands. This paper provides a summary of the current state of knowledge of sea level-rise and its effects on both human and natural ecosystems. The focus is on coastal urban areas and low lying deltas in South-East Asia and Vietnam, as one of the most threatened areas in the world. About 3 mm per year reflects the growing consensus on the average SLR worldwide. The trend speeds up during recent decades. The figures are subject to local, temporal and methodological variation. In Vietnam the average values of 3.3 mm per year during the 1993-2014 period are above the worldwide average. Although a basic conceptual understanding exists that the increasing global frequency of the strongest tropical cyclones is related with the increasing temperature and SLR, this relationship is insufficiently understood. Moreover the precise, complex environmental, economic, social, and health impacts are currently unclear. SLR, storms and changing precipitation patterns increase flood risks, in particular in urban areas. Part of the current scientific debate is on how urban agglomeration can be made more resilient to flood risks. Where originally mainly technical interventions dominated this discussion, it becomes increasingly clear that proactive special planning, flood defense, flood risk mitigation, flood preparation, and flood recovery are important, but costly instruments. Next to the main focus on SLR and its effects on resilience, the paper reviews main SLR associated impacts: Floods and inundation, salinization, shoreline change, and effects on mangroves and wetlands. The hazards of SLR related floods increase fastest in urban areas. This is related with both the increasing surface major cities are expected to occupy during the decades to come and the increasing coastal population. In particular Asia and its megacities in the southern part of the continent are increasingly at risk. The discussion points to complexity, inter-disciplinarity, and the related uncertainty, as core characteristics. An integrated combination of mitigation, adaptation and resilience measures is currently considered as the most indicated way to resist SLR today and in the near future.References Aerts J.C.J.H., Hassan A., Savenije H.H.G., Khan M.F., 2000. Using GIS tools and rapid assessment techniques for determining salt intrusion: Stream a river basin management instrument. 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Background Over 100,000 primary knee arthroplasty operations are undertaken annually in the UK. Around 15–30% of patients do not report a good outcome. Better rehabilitation strategies may improve patient-reported outcomes. Objectives To compare the outcomes from a traditional outpatient physiotherapy model with those from a home-based rehabilitation programme for people assessed as being at risk of a poor outcome after knee arthroplasty. Design An individually randomised, two-arm controlled trial with a blinded outcome assessment, a parallel health economic evaluation and a nested qualitative study. Setting The trial took place in 14 NHS physiotherapy departments. Participants People identified as being at high risk of a poor outcome after knee arthroplasty. Interventions A multicomponent home-based rehabilitation package delivered by rehabilitation assistants with supervision from qualified therapists compared with usual-care outpatient physiotherapy. Main outcome measures The primary outcome was the Late Life Function and Disability Instrument at 12 months. Secondary outcomes were the Oxford Knee Score (a disease-specific measure of function); Knee injury and Osteoarthritis Outcome Score; Quality of Life subscale; Physical Activity Scale for the Elderly; EuroQol-5 Dimensions, five-level version; and physical function assessed using the Figure-of-8 Walk Test, 30-Second Chair Stand Test and Single Leg Stance. Data on the use of health-care services, time off work and informal care were collected using participant diaries. Results In total, 621 participants were randomised. A total of 309 participants were assigned to the COmmunity based Rehabilitation after Knee Arthroplasty (CORKA) home-based rehabilitation programme, receiving a median of five treatment sessions (interquartile range 4–7 sessions). A total of 312 participants were assigned to usual care, receiving a median of four sessions (interquartile range 2–6 sessions). The primary outcome, Late Life Function and Disability Instrument function total score at 12 months, was collected for 279 participants (89%) in the home-based CORKA group and 287 participants (92%) in the usual-care group. No clinically or statistically significant difference was found between the groups (intention-to-treat adjusted difference 0.49 points, 95% confidence interval –0.89 to 1.88 points; p = 0.48). There were no statistically significant differences between the groups in any of the patient-reported or physical secondary outcome measures at 6 or 12 months post randomisation. The health economic analysis found that the CORKA intervention was cheaper to provide than usual care (£66 less per participant). Total societal costs (combining health-care costs and other costs) were lower for the CORKA intervention than usual care (£316 less per participant). Adopting a societal perspective, CORKA had a 75% probability of being cost-effective at a threshold of £30,000 per quality-adjusted life-year. Adopting the narrower health and social care perspective, CORKA had a 43% probability of being cost-effective at the same threshold. Limitations The interventions were of short duration and were set within current commissioning guidance for UK physiotherapy. Participants and treating therapists could not be blinded. Conclusions This randomised controlled trial found no important differences in outcomes when post-arthroplasty rehabilitation was delivered using a home-based, rehabilitation assistant-delivered rehabilitation package or a traditional outpatient model. However, the health economic evaluation found that when adopting a societal perspective, the CORKA home-based intervention was cost-saving and more effective than, and thus dominant over, usual care, owing to reduced time away from paid employment for this group. Further research could look at identifying the risk of poor outcome and further evaluation of a cost-effective treatment, including the workforce model to deliver it. Trial registration Current Controlled Trials ISRCTN13517704. Funding This project was funded by the National Institute for Health Research (NIHR) Health Technology Assessment programme and will be published in full in Health Technology Assessment; Vol. 24, No. 65. See the NIHR Journals Library website for further project information.

Introduction. The VES-13 is a simple, self-reported, function based tool originally developed to screen community-dwelling populations to identify persons age 65 years and older at risk of death and functional decline, including death in the next 12 months. The VES-13 items include patient's age, self-rated overall health status, functional limitations in physical activity, and functional disabilities in more complex activities of daily living. As part of the Lymphoma Epidemiology of Outcomes (LEO) cohort study, we collected self-reported VES-13 data at study enrollment on all participants regardless of age, and here we report on the prevalence of vulnerable status defined by the VES-13 and its association with 1-year mortality, overall, stratified at age 65 years, and in the subset of diffuse large B-cell lymphoma (DLBCL) treated with immunochemotherapy. Methods. From 7/2015 to 6/2017, 3253 participants with NHL were enrolled within 6 months of their diagnosis into the LEO cohort. 2004 were evaluable on VES-13, and 1183 (59%) completed it before the initiation of therapy. VES-13 scores range from a minimum of 0 (low risk for decline) to a maximum of 10 (greatest risk for decline), and a score ≥3 was classified as vulnerable. Clinical, pathology and treatment data were abstracted using a standard protocol, and participants were contacted every 6 months for the first three years and then annually thereafter to identify outcomes. Medical records were reviewed by LEO clinicians to classify cause of death according to a standard protocol. Therapy was determined by the treating physician, and this was independent of knowledge of the VES-13 score. The association of VES-13 with 1-year mortality from date of diagnosis was estimated using odds ratios (OR) and 95% confidence intervals (CI) from logistic regression models, which also provided model c-statistics. Results. The median age of the 2004 participants in this analysis was 62 years (range 18-94); 57% were male; 54% were ≥65 years; and 28% had a normal body mass index (BMI), 1% were underweight, 35% were overweight, and 36% were obese. Clinically, 59% of participants had an aggressive subtype, 65% were stage III-IV, 24% had B-symptoms, and 11% had a performance status (PS) of ≥2. Overall, 28% of participants were classified as vulnerable (95% CI 26%-30%), with a higher prevalence among those completing the survey after initiation of therapy (38%, 95% 34%-41%) versus before initiation of therapy (22%, 95% CI 20%-24%), and a higher prevalence for those ≥65 years (32%, 95% CI 29%-34%) versus <65 (25%, 95% CI 22%-28%). During the first year of follow-up, there were 147 deaths, with 61% due to lymphoma, 14% therapy-related, 12% due to another malignancy, 3% other causes, and 10% unknown. Significant univariate predictors of 1-year mortality included vulnerable status, older age, PS 2+, stage III-IV, aggressive subtype, lower quality of life score, lower BMI, and 1 or more comorbidities, and were included the backward stepwise modeling. Vulnerable status (OR=3.26, 95% CI 2.15-4.96) was retained in the final model that also included age, PS, stage, and NHL subtype (Table), with a model c-statistic of 0.81. As shown in the Table, these associations were similar whether VES-13 was assessed before (c-statistic 0.77) or after (c-statistic 0.81) initiation of therapy. After adjustment for age, PS, stage and NHL subtype, vulnerable status predicted 1-year mortality in participants ≥65 years (OR=1.96, 95% CI 1.15-3.36; model c-statistic 0.80) as well as <65 years (OR=6.38, 95% CI 3.07-13.3; model c-statistic 0.83). Finally, in the DLBCL patients treated with immunochemotherapy (N=521), vulnerable status (38% of patients) also predicted 1-year mortality (OR=2.11, 95% CI 1.05-4.26) after adjusting for age, PS and stage (model c-statistic 0.78). Conclusion. Based on a self-administered VES-13, 28% of newly diagnosed NHL patients in the LEO cohort were classified as vulnerable, including 25% of those <65 years, and vulnerable status was a strong predictor of 1-year-mortality, even in the subset of DLBCL patients treated with presumed curative intent. These results highlight the potential value of screening for vulnerable status overall and across a wider age spectrum in order to optimize patient management and reduce early mortality. Disclosures Martin: Karyopharm: Consultancy; Sandoz: Consultancy; I-MAB: Consultancy; Celgene: Consultancy; Janssen: Consultancy; Teneobio: Consultancy. Casulo:Gilead: Honoraria, Other: Travel, accommodation, expenses; Celgene: Research Funding; Roche: Other: Travel, accommodation, expenses. Cohen:Takeda Pharmaceuticals North America, Inc.: Research Funding; Bristol-Meyers Squibb Company: Research Funding; Hutchison: Research Funding; Astra Zeneca: Research Funding; Lymphoma Research Foundation: Research Funding; ASH: Research Funding; LAM Therapeutics: Research Funding; UNUM: Research Funding; Gilead/Kite: Consultancy; Janssen Pharmaceuticals: Consultancy; Seattle Genetics, Inc.: Consultancy, Research Funding; Genentech, Inc.: Consultancy, Research Funding. Farooq:Kite Pharma: Research Funding; Celgene: Honoraria. Friedberg:Acerta: Other: Data & Safety Monitoring Committee; Bayer: Honoraria, Other: Data & Safety Monitoring Committee. Kahl:Seattle Genetics: Consultancy; ADC Therapeutics: Consultancy, Research Funding; BeiGene: Consultancy; TG Therapeutics: Consultancy. Lossos:Janssen Scientific: Membership on an entity's Board of Directors or advisory committees; NIH: Research Funding; Seattle Genetics: Membership on an entity's Board of Directors or advisory committees. Maurer:Nanostring: Research Funding; Celgene: Research Funding; Morphosys: Membership on an entity's Board of Directors or advisory committees. Nastoupil:Spectrum: Honoraria; Genentech, Inc.: Honoraria, Research Funding; Gilead: Honoraria; Janssen: Honoraria, Research Funding; Novartis: Honoraria; TG Therapeutics: Honoraria, Research Funding; Bayer: Honoraria; Celgene: Honoraria, Research Funding. Rutherford:Heron: Consultancy, Honoraria; Janssen Scientific Affairs: Consultancy, Honoraria; AstraZeneca: Consultancy, Honoraria; Celgene: Consultancy, Honoraria; Juno Therapeutics Inc: Consultancy, Honoraria; Seattle Genetics: Consultancy, Honoraria; Verastem: Consultancy, Honoraria; Karyopharm: Honoraria, Membership on an entity's Board of Directors or advisory committees. Flowers:National Cancer Institute: Research Funding; BeiGene: Consultancy, Research Funding; Eastern Cooperative Oncology Group: Research Funding; Genentech, Inc./F. Hoffmann-La Roche Ltd: Consultancy, Research Funding; Pharmacyclics/Janssen: Consultancy, Research Funding; AbbVie: Consultancy, Research Funding; Bayer: Consultancy; Spectrum: Consultancy; Karyopharm: Consultancy; Acerta: Research Funding; TG Therapeutics: Research Funding; Millenium/Takeda: Research Funding; AstraZeneca: Consultancy; Optimum Rx: Consultancy; V Foundation: Research Funding; Celgene: Consultancy, Research Funding; Burroughs Wellcome Fund: Research Funding; Denovo Biopharma: Consultancy; Gilead: Consultancy, Research Funding. Cerhan:NanoString: Research Funding; Janssen: Membership on an entity's Board of Directors or advisory committees; Celgene: Research Funding.

The first year of membership of the Helmholtz-Zentrum Dresden-Rossendorf (HZDR) in the Helmholtz Association of German Research Centers (HGF) was a year of many changes also for the Institute of Ion Beam Physics and Materials Research (IIM). The transition period, however, is not yet over, since the full integration of the Center into the HGF will only be completed in the next period of the so-called program-oriented funding (POF). This funding scheme addresses the six core research fields identified by the Helmholtz Association (Energy; Earth and Environment; Health; Key Technologies; Structure of Matter; Aeronautics, Space and Transport) to deal with the grand challenges faced by society, science and industry. Since the Institute has strong contributions to both core fields “Key Technologies” and “Structure of Matter”, intense discussions were held amongst the leading scientists of the Institute, across the Institutes of the HZDR, and finally with leading scientists of other Helmholtz centers, to determine the most appropriate classification of the Institute’s research. At the end we decided to establish ourselves in Structure of Matter, the core field in which most of the large-scale photon, neutron and ion facilities in Germany are located. As a consequence, the Ion Beam Center (IBC) of the Institute submitted an application to become a HGF recognized large-scale facility, providing more than 50% of its available beam time to external users. This application perfectly reflects the development of the IBC over more than a decade as a European Union funded infrastructure in the framework of the projects “Center for Application of Ion Beams in Materials Research (AIM)” (1998-2000, 2000-2003, 2006-2010) and subsequently as the coordinator of the integrated infrastructure initiative (I3) “Support of Public and Industrial Research using Ion Beam Technology (SPIRIT)” (2009-2013). Another part of the Institute’s activities is dedicated to exploit the infrared/THz free-electron laser at the 40 MeV superconducting electron accelerator ELBE for condensed matter research. This facility is also open to external users and funded by the European Union.

The year 2013 was the third year of HZDR as a member of the Helmholtz Association (HGF), and we have made progress of integrating ourselves into this research environment of national Research centers. In particular, we were preparing for the evaluation in the framework of the so-called program oriented funding (POF), which will hopefully provide us with a stable funding for the next five years (2015 – 2019). In particular, last fall we have submitted a large proposal in collaboration with several other research centers. The actual evaluation will take place this spring. Most of our activities are assigned to the program “From Matter to Materials and Life” (within the research area “Matter”). A large fraction of this program is related to the operation of large-scale research infrastructures (or user facilities), one of which is our Ion Beam Center (IBC). The second large part of our research is labelled “in-house research”, reflecting the work driven through our researchers without external users, but still mostly utilizing our large-scale facilities such as the IBC, and, to a lesser extent, the free-electron laser. Our in-house research is performed in three so-called research themes, as depicted in the schematic below. What is missing there for simplicity is a small part of our activities in the program “Nuclear Waste Management and Safety” (within the research area “Energy”).

In 2012 the HZDR, and in consequence also the Institute of Ion Beam Physics and Materials Research (IIM) including its Ion Beam Center (IBC), has undergone a scientific evaluation. The evaluation committee composed of the Scientific Advisory Board and numerous external experts in our field of research concluded that “the overall quality of the scientific work is excellent”, that “there are an impressive number of young scientists working enthusiastically on a variety of high-level projects” and that “the choice of these projects represents a clear underlying strategy and vision”. We feel honored and are proud that the external view on our scientific achievements is that extraordinary. In view of this outstanding result we would like to express our gratitude to all our staff members for their commitment and efforts! In the past year, we continued our integration into the Helmholtz Association of German Research Centers (HGF) with our Institute mostly active in the research area “Matter”, but also involved in a number of activities in the research area “Energy”. In this respect, many consultations were held with the Helmholtz centers contributing to common research areas to precisely define the role we will play in the newly established HGF program “From Matter to Materials and Life” (see schematic below). Our IBC has been recognized as a large-scale user facility for ion beam analysis and modification of materials, i.e., specializing on materials science. In particular, the IBC plays a prominent role in the recently approved Helmholtz Energy Materials Characterization Platform (HEMCP), which mainly concentrates on the development of dedicated analytical tools for the characterization of materials required for future energy technologies. The successes achieved by the IBC allows us to invest 7200 k€ to further improve and strengthen the ion beam capabilities at the Institute. In addition to this infrastructure-related grant, we were also successful in our funding application for the establishment of the International Helmholtz Research School for Nanoelectronic Networks (IHRS NANONET), aiming at promoting the next generation of leading scientists in the field of nanoelectronics. The IHRS NANONET is coordinated by our Institute and offers a well-structured PhD program to outstanding students of all nationalities with emphasis on interdisciplinary research and comprehensive training in technical and professional skills.

This past year 2014 was the year when we finally completely arrived as a “full member” in the Helmholtz Association. This is related to the successfully passed research evaluation in the framework of the Program Oriented Funding (POF), which will give us a stable and predictable funding for the next five years (2015 – 2019). This is particularly true for our large-scale user facilities, like the Ion Beam Center (IBC) and the electron accelerator ELBE with the free-electron laser. Most of our activities are assigned to the program “From Matter to Materials and Life” within the research area “Matter”, in cooperation with several other German Helmholtz Centers. Our in-house research is performed in three so-called research themes, as depicted in the schematic below. What is missing there for simplicity is a small part of our activities in the program “Nuclear Waste Management and Safety” within the research area “Energy”. Our research and facilities were well appreciated by the evaluation committee, who made the following judgement about the Ion Beam Center: “The Ion Beam Centre (IBC) of HZDR is an internationally leading ion-beam facility (with ion energies ranging from several eV to several tens of MeV). At both the national and international level it is one of the key players and is unique in its kind. The synergy between forefront research and user service has been leading to a very good publication output for both in-house research and user research. … The very broad range of beam energies, the versatility of techniques and applications – both for ion beam modification of materials and for ion-beam analysis – makes the IBC unique in its kind. … The strength of IBC is that its activities are based on a combination of forefront research and user service, which mutually interact in synergy and strengthen one another. In turn, this synergy has been leading to a very good publication output for both in-house research and user research.” In order to make our Annual Report a bit more compact, we have decided to include only four full journal papers this year. This was also triggered by the fact that our publication activities have turned out be become more diverse, in more diverse journals than in the past, and often through longer papers, which would be too long to reprint them here. However, apart from the constantly quantitatively high publication output, we succeeded to publish in excellent journals such as Nature Physics, Nano Letters and Physical Review Letters, in fields as diverse as ion beam physics, magnetism and terahertz spectroscopy. Two of our scientists, Dr. Artur Erbe and Dr. Alexej Pashkin obtained their Habilitation in 2014, both at University of Konstanz. For the first time, we are hosting an Emmy Noether Young Investigator Group funded by the Deutsche Forschungsgemeinschaft (DFG); the group works on the hot topic of magnonics and is headed by Dr. Helmut Schultheiß. Finally we would like to cordially thank all partners, friends, and organizations who supported our progress in 2014. Special thanks are due to the Executive Board of the Helmholtz-Zentrum Dresden-Rossendorf, the Minister of Science and Arts of the Free State of Saxony, and the Minister of Education and Research of the Federal Government of Germany. Numerous partners from universities, industry and research institutes all around the world contributed essentially, and play a crucial role for the further development of the institute. Last but not least, the directors would like to thank again all IIM staff for their efforts and excellent contributions in 2014.

When Caxton Foster of the University of Massachusetts published his book Computer Architecture in 1970, this term was only just being recognized, reluctantly, by the computing community. This despite an influential paper published in 1964 by a group of IBM engineers on the “Architecture of the IBM System/360.” For instance, ACM’s “Curriculum 68” made no mention of the term in its elaborate description of the entire scope of computing as an academic discipline. Rather, in the late 1960s and well into the ’70s terms such as computer organization, computer structures, logical organization, computer systems organization, or, most blandly, computer design were preferred to describe computers in an abstract sort of way, independent of the physical (hardware) details. Thus a widely referenced paper by Michael Flynn of Stanford University, published in 1974, was titled “Trends and Problems in Computer Organization.” And Maurice Wilkes, even in the third edition of his Time-Sharing Computer Systems (1975) declined to use the term computer architecture. Yet, computer architecture as both an abstract way of looking at, understanding, and designing computers, and as a field of computer science emerged in the first years of the ’70s. The Institute of Electrical and Electronics Engineers (IEEE) founded a Technical Committee on Computer Architecture (TCCA) in 1970 to join the ranks of other specialist IEEE TCs. The Association for Computing Machinery (ACM) followed suit in 1971 by establishing, alongside other special-interest groups, the Special Interest Group on Computer Architecture (SIGARCH). And in 1974, the first of what came to be the annual International Symposium on Computer Architecture (ISCA) was held in Gainesville, Florida. By the end of the decade a series of significant textbooks and articles bearing the term computer architecture(s) had appeared. The reason for naming an aspect of the computer its “architecture” and the reason for naming an academic and research discipline “computer architecture” can be traced back to the mid-1940s and the paradigm-shaping unpublished reports by John von Neumann of the Institute of Advanced Study, Princeton, and his collaborators, Arthur Burks and Herman Goldstine.