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Journal articles on the topic 'Research Support, N.I.H., Extramural'

Author: Grafiati

Published: 4 June 2021

Last updated: 28 July 2025

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1

Ebanks, Yasheca, and Lauren Aleksunes. "109 Pursuit of Fellowship Funding Through Peer Review Writing Groups." Journal of Clinical and Translational Science 7, s1 (2023): 32. http://dx.doi.org/10.1017/cts.2023.192.

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OBJECTIVES/GOALS: Pursuit of independent funding by predoctoral and postdoctoral fellows requires navigating the intricate steps in preparing extramural grant applications. The Workforce Development Core of the NJ Alliance for Clinical and Translational Science (NJ ACTS) sought to evaluate an interactive grant writing group of fellows mentored by a trained coach. METHODS/STUDY POPULATION: Participants meet weekly for 3 months to develop components of a fellowship application for submission to NIH and private foundations. Sessions were moderated by a senior faculty member trained as a coach by

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Malik, Romana Fattimah, Carina G. J. M. Hilders, and Fedde Scheele. "Do ‘physicians in the lead’ support a holistic healthcare delivery approach? A qualitative analysis of stakeholders’ perspectives." BMJ Open 8, no. 7 (2018): e020739. http://dx.doi.org/10.1136/bmjopen-2017-020739.

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ObjectivesValue-based healthcare implies that healthcare issues are addressed most effectively with the ‘physicians in the lead' (PIL) strategy. This study explores whether PIL also supports a holistic care approach that patients are increasingly demanding.DesignA qualitative research design was used.SettingThis study was conducted in a general hospital in the Netherlands with an integrated PIL strategy.ParticipantsSemistructured interviews were conducted with 14 hospital stakeholders: 13 stakeholders of an Obstetrics and Gynaecology department (the hospital’s Patient Council (n=1), nurses (n=

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Yamazawa, Erika, Satoshi Takahashi, Masahiro Shin, et al. "MRI-Based Radiomics Differentiates Skull Base Chordoma and Chondrosarcoma: A Preliminary Study." Cancers 14, no. 13 (2022): 3264. http://dx.doi.org/10.3390/cancers14133264.

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Chordoma and chondrosarcoma share common radiographic characteristics yet are distinct clinically. A radiomic machine learning model differentiating these tumors preoperatively would help plan surgery. MR images were acquired from 57 consecutive patients with chordoma (N = 32) or chondrosarcoma (N = 25) treated at the University of Tokyo Hospital between September 2012 and February 2020. Preoperative T1-weighted images with gadolinium enhancement (GdT1) and T2-weighted images were analyzed. Datasets from the first 47 cases were used for model creation, and those from the subsequent 10 cases we

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Shams-White, Marissa M., Rolando Barajas, Roxanne E. Jensen, et al. "Systems epidemiology and cancer: A review of the National Institutes of Health extramural grant portfolio 2013–2018." PLOS ONE 16, no. 4 (2021): e0250061. http://dx.doi.org/10.1371/journal.pone.0250061.

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Objectives Systems epidemiology approaches may lead to a better understanding of the complex and dynamic multi-level constellation of contributors to cancer risk and outcomes and help target interventions. This grant portfolio analysis aimed to describe the National Institutes of Health (NIH) and the National Cancer Institute (NCI) investments in systems epidemiology and to identify gaps in the cancer systems epidemiology portfolio. Methods The analysis examined grants funded (2013–2018) through seven NIH systems science Funding Opportunity Announcements (FOAs) as well as cancer-specific syste

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Gardner, Jachael, Terry Nakazono, Jim Morrison, Kishore Athreya, Paige Hall, and Pamela Davidson. "45022 Exploring Career Development Needs of Junior Investigators in Clinical Translational Science." Journal of Clinical and Translational Science 5, s1 (2021): 61–62. http://dx.doi.org/10.1017/cts.2021.562.

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ABSTRACT IMPACT: By understanding Junior investigator characteristics and CTSA support services which strongly influence scientific productivity and impact, we will inform and improve research training and enhance the career development of future generations of clinical and translational science researchers. OBJECTIVES/GOALS: In the field of clinical and translational science, the career trajectory and definition of Junior Investigators (JIs) vary greatly. This study aims to investigate JI characteristics, training, and support that contribute to career development at the University of Califor

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Matsie, Nthama. "Daily lived experiences of Visually Impaired Learners at a Mainstream School in Lesotho." International Journal of Studies in Psychology 1, no. 3 (2021): 1–17. http://dx.doi.org/10.38140/ijspsy.v1i3.656.

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Learners with disabilities, particularly the visually impaired face different challenges in their learning encounters. The study explored the daily-lived experiences of visually impaired learners at a mainstream school in Lesotho. A qualitative research approach located in the interpretivist paradigm was adopted. Thirty (n=30) visually impaired learners were purposefully selected in this study. Data were collected using focus group interviews. The Interpretive Phenomenological Analysis was used to analyse and interpret data. The results showed both rewarding and detrimental daily lived experie

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Grover, Sandeep, B. M. Gupta, and K. K. Mueen Ahmed. "COVID-19 and Substance Use: A Scientometric Assessment of Global Publications During 2020 and 2021." Journal of Pharmacology and Pharmacotherapeutics 13, no. 1 (2022): 40–47. http://dx.doi.org/10.1177/0976500x221080393.

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Aim: This study aimed to assess the characteristics and trends of research on substance use and COVID-19. Methods: Keywords related to “Covid-19” and “Substance Use” were used in a search query formulated for the Scopus search engine. The articles published during the years 2020 and 2021, through early November 2021, were considered. Results: A total of 2184 publications were published on this topic, averaging 9.69 citations per paper. About one-seventh (13.96%) share of global publications was supported by extramural funding support. The maximum number of publications emerged from the United

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Coussens, Nathan P., Thomas S. Dexheimer, Eric M. Jones, et al. "Abstract 3090: Development and performance of the National Cancer Institute’s HTS384 NCI60 screen: A modernized platform to support drug discovery and development by the worldwide cancer research community." Cancer Research 84, no. 6_Supplement (2024): 3090. http://dx.doi.org/10.1158/1538-7445.am2024-3090.

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Abstract The NCI60 screen was established in the 1980s and introduced in the 1990s as a screening service for the worldwide cancer research community. The screen features 60 human tumor cell lines that represent 9 cancer types including non-small cell lung, colon, central nervous system, ovarian, renal, prostate and breast, as well as leukemia and melanoma. On a weekly basis, synthetic molecules, natural products, and biologics are screened against the 60-cell line panel to evaluate their anticancer potential. On average, more than 13,000 compounds are screened annually for investigators throu

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Spence, John Paul, Christina R. Santangelo, Jennifer L. Buddenbaum, Aaron E. Carroll, and Matthew R. Allen. "38460 Independent Investigator Incubator (I3) yields external funding within three years for the majority of junior faculty." Journal of Clinical and Translational Science 5, s1 (2021): 64. http://dx.doi.org/10.1017/cts.2021.567.

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ABSTRACT IMPACT: The Independent Investigator Incubator program provides 1:1 mentoring from ‘super-mentors’ to enhance junior faculty careers in research. OBJECTIVES/GOALS: In 2014, the Indiana University School of Medicine (IUSM) in collaboration with the Indiana CTSI established the Independent Investigator Incubator (I3) Program. The I3 Program is designed to provide 1:1 mentoring for new research faculty during the crucial early years of their careers. Our goal is to provide an overview of the I3 design and 5-year data. METHODS/STUDY POPULATION: The I3 Program employs a resource-sharing, c

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Kindler, Carolin, and Uwe Fritz. "Phylogeography and taxonomy of the barred grass snake (Natrix helvetica), with a discussion of the subspecies category in zoology." Vertebrate Zoology 68, no. 3 (2018): 269–81. http://dx.doi.org/10.3897/vz.68.e31615.

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Using 12 microsatellite loci, mitochondrial DNA sequences and previously published morphological evidence, we examined the phylogeographic and taxonomic structure of Natrix helvetica. Our results support tentatively the recognition of five subspecies: (1) N. h. helvetica (Lacepède, 1789) from Western Europe, (2) N. h. cetti Gené, 1839 from Sardinia, (3) N. h. corsa (Hecht, 1930) from Corsica, (4) N. h. lanzai Kramer, 1970 from the Po drainage and peninsular Italy, except for parts of Calabria and perhaps Apulia, and (5) N. h. sicula (Cuvier, 1829) from Sicily and parts of Calabria. The status

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Kindler, Carolin, and Uwe Fritz. "Phylogeography and taxonomy of the barred grass snake (Natrix helvetica), with a discussion." Vertebrate Zoology 68 (November 20, 2018): 269–81. https://doi.org/10.3897/vz.68.e31615.

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Using 12 microsatellite loci, mitochondrial DNA sequences and previously published morphological evidence, we examined the phylogeographic and taxonomic structure of Natrix helvetica. Our results support tentatively the recognition of five subspecies: (1) N. h. helvetica (Lacepède, 1789) from Western Europe, (2) N. h. cetti Gené, 1839 from Sardinia, (3) N. h. corsa (Hecht, 1930) from Corsica, (4) N. h. lanzai Kramer, 1970 from the Po drainage and peninsular Italy, except for parts of Calabria and perhaps Apulia, and (5) N. h. sicula (Cuvier, 1829) from Sicily and parts of Calabria. The status

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Gill, Christian M., Tomefa E. Asempa та David P. Nicolau. "1296. Efficacy of Human-Simulated Exposures of Meropenem/Vaborbactam (MVB) and Meropenem (MEM) against OXA-48 β-lactamase-producing Enterobacterales in the Neutropenic Murine Thigh Infection Model". Open Forum Infectious Diseases 7, Supplement_1 (2020): S663. http://dx.doi.org/10.1093/ofid/ofaa439.1479.

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Abstract Background OXA-48 exhibits variable hydrolytic activity toward carbapenems, with imipenem and meropenem MICs, though increased, often reporting within the ‘susceptible’ or ‘intermediate’ ranges defined by CLSI and EUCAST. Although vaborbactam (VAB) does not enhance MEM activity against OXA-48, ~ 1/3 of OXA-48-producing Enterobacterales will test susceptible to MVB due to its higher breakpoint. Clinical implications of this discordance warrant investigation. Methods 26 isolates harboring OXA-48 (n=24) and KPC (n=2) were evaluated in the neutropenic murine thigh model. MICs were determi

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Unbehauen, H., and I. Vakilzadeh. "Centralized Control of n Identical Plants." Journal of Dynamic Systems, Measurement, and Control 115, no. 3 (1993): 325–33. http://dx.doi.org/10.1115/1.2899106.

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In an elegant and yet easily comprehensible and applicable way, it is shown how the outputs of n identical plants G(s)=K/sp∏l=1μ(s+al) with different output initial conditions can be made to perfectly track a reference, or command, input r(t) through the commissioning of only one central controller H(s). Two simulations support the theoretical results. The proposed technique has wide applications in industrial plants and research centers: it drastically reduces the effort and cost of controllers dictated by the orthodox one-plant/one-controller philosophy.

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Gill, Christian M., Kamilia Abdelraouf, and David P. Nicolau. "1244. Assessment of the In Vivo Activity of Human-Simulated Exposure of WCK 4282 (High Dose Cefepime [FEP]-Tazobactam [TZB]) against Enterobacterales (EB) and Pseudomonas aeruginosa (PA) in the Neutropenic Murine Thigh Infection Model." Open Forum Infectious Diseases 7, Supplement_1 (2020): S640—S641. http://dx.doi.org/10.1093/ofid/ofaa439.1429.

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Abstract Background Carbapenems are often used for infections due to extended-spectrum-β-lactamase (ESBL) and cephalosporinase (CSase)-producers. As increased carbapenem utilization is associated with the development of carbapenem resistance, antimicrobial stewardship has targeted non-carbapenem options. WCK 4282 (FEP 2 g-TZB 2 g) offers pharmacodynamically optimized TZB exposure and demonstrated potent activity in vitro against ESBL-phenotype isolates. We describe the pharmacodynamics of a WCK 4282 human-simulated regimen (HSR) in the neutropenic murine thigh model. Methods 19 clinical strain

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Timme, Cindy R., Yvonne A. Evrard, Biswajit Das, et al. "Abstract 6911: Expanding reported molecular characteristics for the NCI Patient-Derived Models Repository." Cancer Research 84, no. 6_Supplement (2024): 6911. http://dx.doi.org/10.1158/1538-7445.am2024-6911.

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Abstract The National Cancer Institute’s Patient-Derived Models Repository (NCI PDMR; https://pdmr.cancer.gov) has developed a national repository of Patient-Derived Models (PDMs) comprised of patient-derived xenografts (PDXs), in vitro patient-derived tumor cell cultures (PDCs) and cancer associated fibroblasts (CAFs) as well as patient-derived organoids (PDOrg). These PDMs are clinically annotated with molecular information available in an easily accessible database for the extramural community. To ensure the data and models remains pertinent to current translational efforts, NCI actively re

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Gigol, Tomasz. "Gender Differences in Engagement in Unethical Pro-Organizational Behavior—Two Studies in Poland." Sustainability 13, no. 1 (2020): 39. http://dx.doi.org/10.3390/su13010039.

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The objective of this article is to present the results of research on the differences in unethical pro-organizational behavior between men and women. Enterprises run the risk of loss of reputation as a result of unethical pro-organizational behavior on the part of their staff. Such behavior also stands in opposition to sustainable enterprise development. However, an employee who engages in this type of behavior may suffer guilt and embarrassment. In the long term, this hinders employee well-being. The correlation between engagement in unethical pro-organizational behavior and the respondents’

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Karuppiah, Krishnaveni, Iniya Murugan, Murugesan Sepperumal, and Siva Ayyanar. "A dual responsive probe based on bromo substituted salicylhydrazone moiety for the colorimetric detection of Cd2+ ions and fluorometric detection of F‒ ions: Applications in live cell imaging." International Journal of Bioorganic and Medicinal Chemistry 1, no. 1 (2021): 1–9. http://dx.doi.org/10.55124/bmc.v1i1.20.

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A new fluorimetric and colorimetric dual-mode probe, 4-bromo-2-(hydrazonomethyl) phenol (BHP) has been synthesized and successfully utilized for the recognition of Cd2+/F‒ ions in DMSO/H2O (9:1, v/v) system. The probe displays dual channel of detection via fluorescence enhancement and colorimetric changes upon binding with F‒ and Cd2+ ions respectively. The Job’s plot analysis, ESI-MS studies, Density Functional Theoretical (DFT) calculations, 1H NMR and 19F NMR titration results were confirmed and highly supported the 1:1 binding stoichiometry of the probe was complexed with Cd2+/F‒ ions. Fur

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Shin, Sang yong, and Hyunjoo Lee. "Synthesis of Single-Atom and Dual-Atom Catalyst Using N-Defective C₃N₄." ECS Meeting Abstracts MA2022-02, no. 54 (2022): 2021. http://dx.doi.org/10.1149/ma2022-02542021mtgabs.

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Single-atom catalysts, which have been studied tremendously in the past decade, are emerging as a new class of heterogeneous catalysts. It is now generally known that defect sites play an important role in forming single-atomic structures. In the case of SACs, defective sites provide not only space for fixation of metal precursor, but also electrons for stabilizing positive metal ions. Graphitic carbon nitride (g-C3N4) is one of the ideal 2D materials for the synthesis of SACs. C3N4 has enough anchoring sites which originate from the ordered structure of tri-s-triazines connected together. Fur

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Bartlett, John, Dennis C. Sgroi, Kai Treuner, et al. "HER2 status and prediction of extended endocrine benefit with breast cancer index (BCI) in HR+ patients in the adjuvant tamoxifen: To offer more? (aTTom) trial." Journal of Clinical Oncology 38, no. 15_suppl (2020): 522. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.522.

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522 Background: BCI is a validated gene expression-based assay that stratifies patients based on risk of overall (0-10y) and late (post-5y) distant recurrence (DR) and predicts likelihood of benefit from extended endocrine therapy (EET). The Trans-aTTom study established Level1B validation for BCI (H/I) to predict benefit from EET.1 In this updated Trans-aTTom analysis including HER2 status, BCI (H/I) and prediction of endocrine benefit were further characterized. Methods: Centralized HER2 was determined for all cases according to current ASCO/CAP guidelines. Kaplan-Meier and Cox proportional

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Parakh, Poonam, Meetu Babel, Manish Parakh, et al. "A prospective study to evaluate influence of maternal, obstetric and fetal risk factors on the outcome of asphyxiated neonates born intramurally and extramurally." International Journal of Research in Medical Sciences 7, no. 4 (2019): 1120. http://dx.doi.org/10.18203/2320-6012.ijrms20191310.

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Background: The present study was planned to determine the influence of maternal, obstetric and fetal risk factors on the outcome of intramurally (born at a tertiary care centre) and extramurally (born at a peripheral centre, home or a private facility) born asphyxiated neonates.Methods: It was an observational clinical research with a prospective design and was conducted in Neonatal Intensive Care Unit (NICU), Paediatric Neurology Clinic attached to Department of Paediatrics and Department of Obstetrics and Gynecology, Dr S N Medical College Jodhpur, Rajasthan. A total of 160 asphyxiated neon

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Liefers, Gerrit-Jan, Iris Noordhoek, Kai Treuner, et al. "Breast cancer index (BCI) predicts benefit of two-and-a-half versus five years of extended endocrine therapy in HR+ breast cancer patients treated in the ideal trial." Journal of Clinical Oncology 38, no. 15_suppl (2020): 512. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.512.

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512 Background: For postmenopausal women with hormone receptor positive (HR+) breast cancer, the optimal duration of extended endocrine therapy (EET), after completing 5 years of initial aromatase inhibitor (AI)–based adjuvant therapy, remains unclear. BCI [HOXB13/IL17BR (H/I)] is a gene expression-based biomarker that has been demonstrated to predict EET benefit in the MA.17 and Trans-aTTom studies in patients treated with adjuvant tamoxifen. The current study examined the ability of BCI (H/I) to predict endocrine benefit from 2.5 vs. 5 years of extended letrozole in the IDEAL trial. Methods:

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Lasko, Maxwell J., Kamilia Abdelraouf та David P. Nicolau. "1245. In Vivo Efficacy of WCK 4282 (High Dose Cefepime [FEP]-Tazobactam [TZB]) Against β-Lactamase-Producing (BLP) Gram-Negative Bacteria in a Neutropenic Murine Pneumonia Model". Open Forum Infectious Diseases 7, Supplement_1 (2020): S641. http://dx.doi.org/10.1093/ofid/ofaa439.1430.

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Abstract Background Carbapenems are often used for Extended-Spectrum β-lactamase (ESBL)- and cephalosporinase (AmpC or CMY)-producing infections. Their increased use resulted in the emergence of carbapenem resistance among Gram-negatives, promoting the need of an effective carbapenem-sparing option. WCK 4282 (FEP 2g-TZB 2g) maximizes systemic exposure of TZB and restores FEP activity against piperacillin-tazobactam (TZP) resistant isolates in vitro. Herein we describe the efficacy of WCK 4282 clinical exposures against BLP Enterobacterales (EB) and Pseudomonas aeruginosa (PA) in a murine pneum

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Kambarov, Bakhtiyor, Bakhtiyor Kholikov, Razhabbai Khudaykuliyev, and Aleksandr Lavrov. "Research on the rational aggregation of a transport tractor." E3S Web of Conferences 583 (2024): 05014. http://dx.doi.org/10.1051/e3sconf/202458305014.

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The results of studying the resistance to traction of a tractor train consisting of models Belarus 80.1 tractor and two 2PТС-4-793 trailers, and how this resistance depends on the number of trailers, the load weight Gt , and the speed of movement are specified in the article. Obtained figures indicate that, while the weight of each trailer n remains constant, the force in tractor’s attachment increases as number of trailers increases. Conversely, the resistance coefficient f of support surface's slope angle α and the rolling resistance of the wheels decreases. For investigating the force at tr

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Liefers, Gerrit-Jan, Iris Noordhoek, Kai Treuner, et al. "Breast Cancer Index and prediction of benefit from extended endocrine therapy based on treatment compliance: An IDEAL study." Journal of Clinical Oncology 39, no. 15_suppl (2021): 531. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.531.

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531 Background: The IDEAL trial randomized hormone receptor-positive (HR+) breast cancer patients to 5 vs 2.5y of extended letrozole after completion of 5y of adjuvant endocrine therapy. In the parent trial, approximately 60% of patients overall were compliant with endocrine treatment (59% vs 74% compliance in 5y and 2.5y arms, respectively), with patient experiences as the most significant factors leading to treatment discontinuation. Breast Cancer Index is a gene expression-based signature that predicts which HR+ patients are likely to benefit from extended endocrine therapy (EET) vs those u

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Sharma, Sumit. "ROLE OF ELECTRICAL STIMULATION ADDED TO CONVENTIONAL THERAPY IN PATIENTS WITH TRAUMATIC FACIAL PALSY." UP STATE JOURNAL OF OTOLARYNGOLOGY AND HEAD AND NECK SURGERY Volume 9, upjohns/volume9/Issue2 (2021): 37–43. http://dx.doi.org/10.36611/upjohns/volume9/issue2/7.

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ABSTRACT Background: Facial nerve palsy can have ophthalmological, Otological, rhinological, taste, and swallowing consequences, in addition to the psychological impact of altered facial expression. Electrical Stimulation (ES) is one of the most debatable and non-evidence-based adjunctive therapies for facial palsy. MATERIAL/METHODS We retrieved the literature on ES in facial nerve injury using the Cochrane Database of Systematic Reviews, PubMed, and Google Scholar. Emphasis was placed on articles and randomised controlled trials (RCTs) published within the last 20 years. Results: The reviewed

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Ceniceros, Lucia, Jorge Baixauli, Azucena Aldaz, et al. "Pharmacokinetically-guided preoperative FOLFOX chemotherapy for locally advanced colon cancer patients." Journal of Clinical Oncology 38, no. 15_suppl (2020): 4104. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.4104.

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4104 Background: Preliminary results from ongoing randomised trials suggest that neoadjuvant chemotherapy (NAC) may be an alternative approach to conventional adjuvant therapy. We assessed the feasibility and activity of incorporating a pharmacokinetically (PK) guided dose adjustment of 5-FU within preoperative Folfox. Methods: Radiologically staged LACC pts, T4 or T3 with extramural depth >5mm beyond the muscularis propia, were planned to receive 4-6 biweekly cycles of Oxalipatin (85mg/m²), Leucovorin (400 mg/m²), bolus 5-FU (400 mg/m2) and infusional 5-FU (initial dose of 2400mg/m² in 46h

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Paukner, Susanne, Robert K. Flamm, Steven P. Gelone, and Helio S. Sader. "1365. In Vitro Activity of Lefamulin (LEF) Against Bacterial Pathogens Causing Community-Acquired Bacterial Pneumonia (CABP): SENTRY Surveillance 2016 Results From Asia-Pacific (APAC) and Latin America (LA)." Open Forum Infectious Diseases 5, suppl_1 (2018): S418. http://dx.doi.org/10.1093/ofid/ofy210.1196.

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Abstract Background LEF, a novel pleuromutilin antibiotic for IV and oral use, recently completed a phase 3 trial for the treatment of CABP in adults where it demonstrated noninferiority to moxifloxacin ± linezolid. LEF selectively inhibits bacterial translation. This study investigated the activity of LEF and comparators against contemporary bacterial respiratory pathogens collected from APAC and LA. Methods Unique isolates were collected from patients with pneumonia/respiratory (n = 551), blood stream (n = 169), skin and soft tissue (n = 244), and other (n = 55) infections in seven countries

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Evrard, Yvonne A., Li Chen, Sergio Alcoser, et al. "Abstract 40: NCI patient derived models repository: PDX, organoid and cell lines from the same patient - bridging the translational pipeline." Cancer Research 83, no. 7_Supplement (2023): 40. http://dx.doi.org/10.1158/1538-7445.am2023-40.

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Abstract The National Cancer Institute’s Patient-Derived Models Repository (NCI PDMR; https://pdmr.cancer.gov) has developed a national repository of Patient-Derived Models (PDMs) comprised of patient-derived xenografts (PDXs), in vitro patient-derived tumor cell cultures (PDCs) and cancer associated fibroblasts (CAFs) as well as patient-derived organoids (PDOrg). These PDMs are clinically annotated with molecular information available in an easily accessible database for the extramural community. A key effort in developing these models is to develop matched models sets allowing for larger sca

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Elvin, Julia Andrea, Yuting He, James Sun, et al. "Comprehensive genomic profiling (CGP) with loss of heterozygosity (LOH) to identify therapeutically relevant subsets of ovarian cancer (OC)." Journal of Clinical Oncology 35, no. 15_suppl (2017): 5512. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.5512.

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5512 Background: Defective homologous recombination DNA repair (HRD) is associated with high grade serous (OC-S) histology, longer survival, and platinum (Pt) or PARP inhibitor (PARPi) sensitivity. HRD causes LOH, a pattern of allelic imbalance detectable by CGP. BRCAwt OC-S can have LOH and respond to PARPi, while non-serous (OC-NS) or difficult to classify (OC-NOS) OC are often less responsive to Pt-based therapy. Integrating multiple genomic features derived from CGP may define other therapeutically relevant subsets. Methods: DNA from FFPE tumor tissue obtained during clinical care for 4114

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Puja Sri Rahayu, Emi Mutiara, and Rismayanti Rismayanti. "Analisis Bunyi Bahasa Indonesia: Fonetik Dan Fonemik." Sintaksis : Publikasi Para ahli Bahasa dan Sastra Inggris 1, no. 4 (2023): 54–60. http://dx.doi.org/10.61132/sintaksis.v1i4.223.

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This research uses the method of analyzing language sound phonemes to understand how the sounds of Indonesian are organized in its phonological system. The results are expected to provide in-depth insight into the sound structure of this language, support linguistic understanding and contribute to the development of language teaching methods. This research shows that phonemes in Indonesian have twenty-three consonant sounds and ten vowel sounds. The twenty-three consonant sounds are [p, b, t, d, c, j, k, ˀ, g, m, n, ŋ, ñ, l, f, s, z, ʃ, x, h, r, w, y]. Meanwhile, the ten vowel sounds are [a, i

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Agung, Tri Sunan, Belinda Safa Salsabila Zuhri, and Shinfi Wazna Auvaria. "Hylopoly-Bag: Environmentally Friendly Bioplastic Innovation Made from Dragon Fruit (Hylocereus polarizes) Peel Waste to Support Golden Indonesia 2045." Jurnal Penelitian Pendidikan IPA 10, no. 10 (2024): 7634–44. http://dx.doi.org/10.29303/jppipa.v10i10.7703.

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Hylopoly-bag is a bioplastic bag from red dragon fruit (H. polyrhizus) skin waste. This research aims to discuss 2 things, namely the quality of hylopoly-bags and the realization of hylopoly-bags in supporting Golden Indonesia 2045. Experimental research uses descriptive quantitative methods. The independent variable is a ratio of dragon fruit peel extract and polyvinyl acetate of 2:1, 4:1, and 6:1, with the final quality of hylopoly-bag as the dependent variable. The analysis technique includes 6 methods: hylopoly-bag chemical content test, functional groups, permeability, elasticity, biodegr

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Abdelraouf, Kamilia, Sergio Reyes та David P. Nicolau. "1299. In Vitro-In Vivo Discordance with β-lactams against Metallo-β-lactamase-Producing Enterobacterales: Implications for Susceptibility Testing". Open Forum Infectious Diseases 7, Supplement_1 (2020): S664. http://dx.doi.org/10.1093/ofid/ofaa439.1482.

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Abstract Background Using murine models of thigh and lung infection, we previously reported the potent in vivo activity of carbapenem human-simulated regimens against metallo-β-lactamase-producing Enterobacterales despite the observed resistance in vitro (JAC 2020 Apr 1;75(4):997-1005, AAC 2014;58(3):1671-7). In the current study, we examined the in vivo activity of cefepime human-simulated regimen against metallo-β-lactamase-producing Enterobacterales in a murine thigh infection model. Methods A population of clinical (n=21) and isogenic engineered (n=5) metallo-β-lactamase-producing Enteroba

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Lin, Frank Y., Jacquelyn Reuther, Samara L. Potter, et al. "Frequency and spectrum of clinically significant molecular alterations detected by tumor gene panel testing for pediatric cancer patients in the Texas KidsCanSeq study." Journal of Clinical Oncology 41, no. 16_suppl (2023): 10018. http://dx.doi.org/10.1200/jco.2023.41.16_suppl.10018.

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10018 Background: Tumor sequencing has the potential to inform diagnosis, prognosis, and treatment of childhood cancer patients. Prospective data are needed to evaluate the clinical utility of these tests. Methods: Patients less than 18 years of age with extracranial solid tumors (ST), central nervous system tumors (CNS), lymphomas and histiocytic disorders (L/H) were enrolled in the Texas KidsCanSeq clinical genomics study at six Texas institutions. Available tumor samples from a subset of patients designated as high risk (based on poor prognosis at diagnosis or tumor recurrence) were sequenc

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Arends, S. J. Ryan, Abby L. Klauer, Nicole Cotroneo, Ian A. Critchley, and Rodrigo E. Mendes. "1041. In vitro activity of tebipenem against a recent collection of fastidious organisms recovered from respiratory tract infections." Open Forum Infectious Diseases 8, Supplement_1 (2021): S611. http://dx.doi.org/10.1093/ofid/ofab466.1235.

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Abstract Background Tebipenem is under development as an oral treatment option for complicated urinary tract infections and acute pyelonephritis. This study further evaluated the in vitro activity of tebipenem against various fastidious organisms recovered from community-acquired respiratory tract infections (CARTIs). Methods The study included a total of 2,476 fastidious organisms: Haemophilus influenzae (692 isolates, including fluoroquinolone-resistant, β-lactamase-positive, and β-lactamase-negative ampicillin-resistant [BLNAR]), Haemophilus parainfluenzae (30 isolates, including β-lactamas

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de Paz Carmona, Héctor, Jakub Frątczak, Zdeněk Tišler, and José Miguel Hidalgo Herrador. "Phonolite Material as Catalyst Support for the Hydrotreatment of Gas Oil and Vegetable Oil Type Feedstocks." Materials 15, no. 1 (2022): 386. http://dx.doi.org/10.3390/ma15010386.

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Phonolite material has shown to be promising catalyst support for the deoxygenation of triglycerides. In this work, we continue with our previous research by synthesising and testing three acid-treated phonolite-supported Co-Mo, Ni-Mo and Ni-W catalysts for the hydrotreating of atmospheric gas oil and co-processing with rapeseed oil at industrial operating conditions (350–370 °C, WHSV 1–2 h−1, 5.5 MPa) in the continuous regime for more than 270 h. The phonolite-supported catalysts showed hydrotreating activity comparable with commercial catalysts, together with a complete conversion of triglyc

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White, Cameron, Jeremy Meeder, Derek Moates, et al. "1027. Earlier Is Better: Progress Toward Decreased Time to Optimal Therapy and Improved Antibiotic Stewardship for Gram-positive Bloodstream Infections Through Use of GenMark Dx ePlex system." Open Forum Infectious Diseases 8, Supplement_1 (2021): S604—S605. http://dx.doi.org/10.1093/ofid/ofab466.1221.

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Abstract Background The ePlex BCID Gram-Positive (GP) panel utilizes electrowetting technology to detect the most common causes of GP bacteremia (20 targets) and 4 antimicrobial resistance (AMR) genes in positive blood culture (BC) bottles. Rapid detection of intrinsic vancomycin resistance and acquired resistance genes (mecA, mecC, vanA, vanB) enables early optimization of antimicrobial therapy whereas early detection of common contaminants is expected to decrease unnecessary antibiotic utilization and hospitalizations. Methods In this prospective study, aliquots of BC bottles with GP bacteri

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Li, Bin, Zheng Han, Ruitong Jiang, et al. "Research on the Ecological Restoration Effects of a Vallisneria natans (Lour.) Hara-Dominated Multitrophic Level Ecosystem." Water 16, no. 7 (2024): 1050. http://dx.doi.org/10.3390/w16071050.

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This study aims to assess the ecological restoration effects of Vallisneria natans in a multitrophic level ecosystem. The water-purification effects of two hierarchical configuration modes of V. natans-Bellamya aeruginosa and V. natans-B. aeruginosa-Hyriopsis cumingii were studied. Results show that a V. natans and B. aeruginosa configuration ratio of 15:2 stabilizes water quality at Grade IV (TN ≤ 1.5 mg/L, TP ≤ 0.3 mg/L), and increasing B. aeruginosa density significantly reduces total phosphorus. The V. natans, B. aeruginosa, and H. cumingii configuration at 15:2:10 stabilizes water at Grad

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Zwart, Koen, Frederieke van der Baan, Matthew Dixon, et al. "Clinical outcomes in patients with microsatellite instability-high (MSI-H) metastatic colorectal cancer (mCRC) in the pre-immunotherapy era." Journal of Clinical Oncology 41, no. 4_suppl (2023): 65. http://dx.doi.org/10.1200/jco.2023.41.4_suppl.65.

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65 Background: Data on clinical treatment outcomes of systemic non-immunotherapy in patients with MSI-H mCRC are limited due to low incidence. Real world data can support the interpretation of immunotherapy studies. Our aim is to provide insight on clinical outcomes of patients with MSI-H mCRC treated with systemic non-immunotherapy. Methods: We describe an observational cohort study with real-world data from the Netherlands Cancer Registry during 2015-2018 (N=383) and trial-based data from three prospective phase III first-line clinical trials: CAIRO, CAIRO2 and CAIRO3 (N=54). We investigated

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Villatoro Villar, M., D. A. Wetter, C. S. Crowson, K. J. Warrington, and M. Koster. "SAT0277 HEAD AND NECK INVOLVEMENT OF IGA VASCULITIS: A CASE-CONTROL STUDY." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 1082.2–1083. http://dx.doi.org/10.1136/annrheumdis-2020-eular.753.

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Background:IgA vasculitis (IgAV) is an immune-complex mediated, small-vessel vasculitis which predominantly involves the skin on the lower extremities. Head and neck involvement is rarely reported.Objectives:To describe the presentation and outcome of a series of patients with head and/or neck involvement in comparison to patients with cutaneous findings isolated to the lower extremities.Methods:Patients with biopsy-proven IgAV from January 1, 1997 through December 31, 2016 were retrospectively identified through direct medical chart review. IgAV was diagnosed in accordance with the American C

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Koroma, Mohamed, Kadiatu Fofanah, Gibrilla Salaam kamara, Alimamy Saidu Konteh, and Idrissa koroma. "Evaluating the Adoption of Virtualization and Cloud Computing as Strategic IT Outsourcing Solutions for Enhancing Educational Efficiency at Njala University." International Research Journal of Innovations in Engineering and Technology 09, no. 05 (2025): 400–416. https://doi.org/10.47001/irjiet/2025.905045.

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The rapid evolution of virtualization and cloud computing presents transformative potential for higher education institutions (HEIs), particularly in resourceconstrained settings like Sierra Leone. Despite their proven benefits in developed nations, significant gaps remain in understanding their adoption challenges and impacts in African HEIs. This study evaluates the implementation of these technologies at Njala University, addressing critical research gaps in IT outsourcing strategies for developing regions. Employing a mixedmethods approach, the research combines quantitative surveys (N = 1

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Seidel, Danila, Oliver Cornely, Maria J. G. T. Vehreschild, et al. "1172. Mucormycosis Treated with Isavuconazole: A matched-Pair Analysis from the FungiScope® Registry." Open Forum Infectious Diseases 7, Supplement_1 (2020): S611—S612. http://dx.doi.org/10.1093/ofid/ofaa439.1358.

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Abstract Background Isavuconazole (ISAV) is a novel, broad-spectrum triazole antifungal, available in both intravenous and oral formulations, for the treatment of adult patients with invasive aspergillosis or mucormycosis. In this retrospective case collection study, we compared outcomes for patients with invasive mucormycosis treated with ISAV versus other systemic antifungal therapies, in order to evaluate the real-world effectiveness of ISAV. Methods Proven and probable invasive mucormycosis cases treated with ISAV for a minimum of four consecutive days between 2016 and 2019 were identified

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de la Monte, Suzanne M., Gina M. Gallucci, Amy Lin, Ming Tong, Xiaodi Chen, and Barbara S. Stonestreet. "Critical Shifts in Cerebral White Matter Lipid Profiles After Ischemic–Reperfusion Brain Injury in Fetal Sheep as Demonstrated by the Positive Ion Mode MALDI-Mass Spectrometry." Cell Medicine 12 (January 1, 2020): 215517901989700. http://dx.doi.org/10.1177/2155179019897002.

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Ischemic–reperfusion (I/R) injury to cerebral white matter during the perinatal period leads to long-term cognitive and motor disabilities in children. Immature white matter oligodendrocytes are especially vulnerable to metabolic insults such as those caused by hypoxic, ischemic, and reperfusion injury. Consequences include an impaired capacity of oligodendrocytes to generate and maintain mature lipid-rich myelin needed for efficient neuronal conductivity. Further research is needed to increase an understanding of the early, possibly reversible myelin-associated pathologies that accompany I/R

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Andre, Thierry, Elena Elez, Eric Van Cutsem, et al. "Nivolumab (NIVO) plus ipilimumab (IPI) vs chemotherapy (chemo) as first-line (1L) treatment for microsatellite instability-high/mismatch repair-deficient (MSI-H/dMMR) metastatic colorectal cancer (mCRC): First results of the CheckMate 8HW study." Journal of Clinical Oncology 42, no. 3_suppl (2024): LBA768. http://dx.doi.org/10.1200/jco.2024.42.3_suppl.lba768.

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LBA768 Background: Patients (pts) with MSI-H/dMMR mCRC have poor outcomes with standard chemo ± targeted therapies. NIVO ± IPI are approved in previously treated pts with MSI-H/dMMR mCRC in many countries, based on the phase 2 CheckMate 142 study. CheckMate 8HW (NCT04008030) is a randomized phase 3 study comparing NIVO + IPI with NIVO or chemo in pts with MSI-H/dMMR mCRC. We report progression-free survival (PFS) by blinded independent central review (BICR) at a prespecified interim analysis for NIVO + IPI vs chemo in the 1L setting. Methods: Pts ≥ 18 years with recurrent or mCRC not amenable

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Finn, Richard S., Michael F. Press, Judy Dering, et al. "Estrogen Receptor, Progesterone Receptor, Human Epidermal Growth Factor Receptor 2 (HER2), and Epidermal Growth Factor Receptor Expression and Benefit From Lapatinib in a Randomized Trial of Paclitaxel With Lapatinib or Placebo As First-Line Treatment in HER2-Negative or Unknown Metastatic Breast Cancer." Journal of Clinical Oncology 27, no. 24 (2009): 3908–15. http://dx.doi.org/10.1200/jco.2008.18.1925.

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PurposeLapatinib is a dual inhibitor of epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2) with activity in HER2-amplified metastatic breast cancer (MBC). Its role in non–HER2-amplified MBC remains unclear. EGF30001, a phase III trial of lapatinib and paclitaxel versus paclitaxel and placebo, demonstrated lapatinib does not significantly benefit HER2-negative or HER2-unselected patients with MBC. Published data support interactions between steroid hormone and peptide growth factor signaling. We hypothesized that molecular subgroups may exist within EGF3

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Ismail, Ahmad Khaldun, Zhi Xuan Ng, Syahirah Rezwan Eskandar, Hamelda Tanisha Ganaprakasam, and Zainalabidin Mohamed. "The frequency, clinical characteristics and outcomes of Naja species related injuries in Malaysia consulted to Remote Envenomation Consultancy Services from 2020–2023." PLOS Neglected Tropical Diseases 19, no. 7 (2025): e0013271. https://doi.org/10.1371/journal.pntd.0013271.

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Naja species bites and envenomation are common in Malaysia. This retrospective cohort study of diagnosed Naja species cases consulted to Remote Envenomation Consultancy Services (RECS) from 2020 to 2023. This study aimed to identify the frequency, geographical distribution, clinical features, treatments, and outcomes of Naja species-related injuries. Data was extracted following the approval of the institutional research ethics committee and all patient’s information were kept anonymous. From 4474 RECS consultations, 512 incidents were diagnosed as caused by Naja species. Naja kaouthia case co

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Hensel, Brooke, Eduardo Ibarra, Carolina Aristizabal, et al. "Abstract A056: Community scientist research advocacy program: Bridging cancer research and community advocacy." Cancer Epidemiology, Biomarkers & Prevention 32, no. 12_Supplement (2023): A056. http://dx.doi.org/10.1158/1538-7755.disp23-a056.

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Abstract Community Scientist Research Advocacy (CSRA) programs are designed to connect researchers with community members, to effectively inform and involve the general population on clinical research. More programs like such are needing to be implemented into the community for better outcomes among cancer health disparities. The purpose of our study was to develop and evaluate a novel bi-coastal and bilingual program to inform, educate and empower community members to become cancer research advocates in Florida (FL) and California (CA). Our program was tailored for African American (AA) and H

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Egge, Stephanie L., Shelby Simar, An Q. Dinh, et al. "1246. Clinical isolates of Pseudomonas aeruginosa Harbor Preexisting Changes in TonB-dependent Receptors Associated with Decreased Susceptibility to Cefiderocol." Open Forum Infectious Diseases 8, Supplement_1 (2021): S711—S712. http://dx.doi.org/10.1093/ofid/ofab466.1438.

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Abstract Background Cefiderocol (FDC) is a novel siderophore cephalosporin that retains activity against MDR gram-negative bacteria. In P. aeruginosa (PA), FDC utilizes TonB-dependent receptors (TBDR) PirA, PiuA, or PiuD to enter the periplasmic space. We recently reported a clinical PA isolate that developed elevated MICs to FDC associated with mutations in genes encoding TBDRs in the absence of prior exposure to FDC. In this study, we investigated the frequency of TBDR mutations not associated with cefiderocol exposure among clinical stains of PA recovered from 1999 to 2018 in a large hospit

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Liubchych, Anna, and Illia Mamaiev. "Topical issues of information support of research infrastructures." Law and innovations, no. 2 (38) (June 24, 2022): 35–41. http://dx.doi.org/10.37772/2518-1718-2022-2(38)-4.

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Problem setting. The construction of an innovation society and ensuring the competitiveness of domestic science depends largely on the effective activity of research infrastructures. In turn, research infrastructures depend on their information support, as information is one of the most valuable resources in the modern world. Analysis of recent researches and publications. Innovative infrastructures were investigated in the works of such domestic scientists as S. V. Hlibko, I. V. Podrez-Riapolova and others. Research infrastructure was considered by N. M. Vnukova, O. V. Holovashchenko, V. P. K

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Hutchinson, Amber, Danyelle Liddle, Rufaida Ansari, and Lindsay Robinson. "Dietary n-3 vs n-6 PUFA Differentially Modulate Macrophage-Myocyte Inflammatory Cross-Talk." Current Developments in Nutrition 4, Supplement_2 (2020): 1644. http://dx.doi.org/10.1093/cdn/nzaa063_042.

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Abstract Objectives Skeletal muscle is the primary site for insulin-stimulated glucose uptake. In obesity, increased circulating inflammatory cytokines interfere with skeletal muscle insulin signaling, leading to local and whole-body insulin resistance (IR). Moreover, obese skeletal muscle is characterized by accumulation of infiltrated M1 macrophages and ensuing macrophage-myocyte paracrine interactions (cross-talk) contribute to local inflammation and IR. Such macrophage-myocyte inflammatory cross-talk provides a potential intervention target for anti-inflammatory nutrients, including dietar

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Chauvin, Sarah, Benoit H. Mulsant, Sanjeev Sockalingam, Vicky Stergiopoulos, Valerie H. Taylor, and Simone N. Vigod. "Gender Differences in Research Productivity among Academic Psychiatrists in Canada." Canadian Journal of Psychiatry 64, no. 6 (2019): 415–22. http://dx.doi.org/10.1177/0706743718802798.

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Objectives: Gender inequity in academic medicine persists despite increases in the number of women physicians. We sought to explore gender differences in research productivity for academic psychiatrists in Canada. Methods: In a cross-sectional study of the 3379 psychiatrists in all 17 university departments of psychiatry in Canada, research productivity, as measured by the h-index and number of publications, was compared between women and men using a negative log binomial regression model to generate relative rates (RRs), adjusted for career duration (aRR). Findings were stratified by academic

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