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Journal articles on the topic 'Residualizing'

Author: Grafiati

Published: 7 June 2021

Last updated: 29 July 2025

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1

Maxwell, J. L., L. Terracio, T. K. Borg, J. W. Baynes, and S. R. Thorpe. "A fluorescent residualizing label for studies on protein uptake and catabolism in vivo and in vitro." Biochemical Journal 267, no. 1 (1990): 155–62. http://dx.doi.org/10.1042/bj2670155.

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Residualizing labels are tracers which remain in lysosomes after uptake and catabolism of the carrier protein and have been especially useful for studies on the sites of plasma protein degradation. Thus far these labels have contained radioactive reporters such as 3H or 125I. In the present paper we describe a fluorescent residualizing label, NN-dilactitol-N′-fluoresceinylethylenediamine (DLF). Modification of asialofetuin (ASF) or rat serum albumin (RSA) with DLF affected neither their normal kinetics of clearance from the rat circulation nor their normal tissue sites of uptake and degradatio

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2

Cho, Nicholas, Phillip Spinosa, Danielle Mandikian, et al. "Abstract 2577: Analyzing specific and nonspecific tissue uptake of antibodies by SPECT imaging and non-linear compartmental modeling." Cancer Research 84, no. 6_Supplement (2024): 2577. http://dx.doi.org/10.1158/1538-7445.am2024-2577.

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Abstract Understanding the mechanisms driving specific target engagement versus off-target nonspecific cellular uptake of antibodies can help inform design and/or delivery strategies that maximize therapeutic indices. Receptor binding kinetics, rates of receptor-mediated internalization and nonspecific pinocytosis are often measured through in vitro cell culture models, but there have been fewer efforts to collectively measure these cellular parameters in vivo. Single photon emission computed tomography (SPECT) imaging is a powerful method of estimating these parameters by quantifying both fre

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3

Minasyan, Ashot. "On Residualizing Homomorphisms Preserving Quasiconvexity#." Communications in Algebra 33, no. 7 (2005): 2423–63. http://dx.doi.org/10.1081/agb-200058383.

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4

Vaidyanathan, Ganesan, Darryl McDougald, Jaeyeon Choi, et al. "N-Succinimidyl 3-((4-(4-[18F]fluorobutyl)-1H-1,2,3-triazol-1-yl)methyl)-5-(guanidinomethyl)benzoate ([18F]SFBTMGMB): a residualizing label for 18F-labeling of internalizing biomolecules." Organic & Biomolecular Chemistry 14, no. 4 (2016): 1261–71. http://dx.doi.org/10.1039/c5ob02258d.

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5

Lee, Fook T., Ingrid J. G. Burvenich, Nancy Guo, et al. "l-Tyrosine Confers Residualizing Properties to ad-Amino Acid-Rich Residualizing Peptide for Radioiodination of Internalizing Antibodies." Molecular Imaging 15 (January 2016): 153601211664753. http://dx.doi.org/10.1177/1536012116647535.

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6

Moerlein, S. M., K. B. Dalal, S. N. Ebbe, Y. Yano, and T. F. Budinger. "Residualizing and non-residualizing analogues of low-density lipoprotein as iodine-123 radiopharmaceuticals for imaging LDL catabolism." International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology 15, no. 2 (1988): 141–49. http://dx.doi.org/10.1016/0883-2897(88)90080-3.

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7

Chitneni, Satish K., Eftychia Koumarianou, Ganesan Vaidyanathan, and Michael R. Zalutsky. "Observations on the Effects of Residualization and Dehalogenation on the Utility of N-Succinimidyl Ester Acylation Agents for Radioiodination of the Internalizing Antibody Trastuzumab." Molecules 24, no. 21 (2019): 3907. http://dx.doi.org/10.3390/molecules24213907.

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Trastuzumab is an antibody used for the treatment of human epidermal growth factor receptor 2 (HER2)-overexpressing breast cancers. Since trastuzumab is an internalizing antibody, two factors could play an important role in achieving high uptake and prolonged retention of radioactivity in HER2-positive tumors after radioiodination—residualizing capacity after receptor-mediated internalization and susceptibility to dehalogenation. To evaluate the contribution of these two factors, trastuzumab was radiolabeled using the residualizing reagent N-succinimidyl 4-guanidinomethyl-3-[*I]iodobenzoate ([

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8

Rinne, Sara S., Tianqi Xu, Charles Dahlsson Leitao, et al. "Influence of Residualizing Properties of the Radiolabel on Radionuclide Molecular Imaging of HER3 Using Affibody Molecules." International Journal of Molecular Sciences 21, no. 4 (2020): 1312. http://dx.doi.org/10.3390/ijms21041312.

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Human epidermal growth factor receptor type 3 (HER3) is an emerging therapeutic target in several malignancies. To select potential responders to HER3-targeted therapy, radionuclide molecular imaging of HER3 expression using affibody molecules could be performed. Due to physiological expression of HER3 in normal organs, high imaging contrast remains challenging. Due to slow internalization of affibody molecules by cancer cells, we hypothesized that labeling (HE)3-ZHER3:08698-DOTAGA affibody molecule with non-residualizing [125I]-N-succinimidyl-4-iodobenzoate (PIB) label would improve the tumor

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9

Daugherty, A., N. N. Becker, L. A. Scherrer, et al. "Non-invasive detection of protein metabolism in vivo by n.m.r. spectroscopy. Application of a novel 19F-containing residualizing label." Biochemical Journal 264, no. 3 (1989): 829–35. http://dx.doi.org/10.1042/bj2640829.

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Protein residualizing labels facilitate localization of tissue sites of protein catabolism and the quantification of protein accumulation because of their prolonged intracellular retention of protein accumulation because of their prolonged intracellular retention times. Radioiodinated residualizing labels have been used to define the metabolism of a wide variety of proteins, but this has necessitated destructive analysis. Here we describe the implementation and validation of a novel 19F-containing residualizing label for protein, NN-dilactitol-3,5-bis(trifluoromethyl)benzylamine (DLBA), that p

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10

Regoeczi, Erwin, Paul A. Chindemi, Maria Bolyos, and Wei-Li Hu. "Observations with a residualizing label in use to map the catabolic sites of plasma proteins." Biochemistry and Cell Biology 72, no. 7-8 (1994): 275–81. http://dx.doi.org/10.1139/o94-039.

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Rat albumin, immunoglobulin G, transferrin, and aglycotransferrin were prepared for the comparison of their sites of degradation in rats. Iodotyramine-cellobiose was used as the residualizing label and a tyrosine-iodinated portion of the corresponding protein was used as the marker of extracellular undegraded protein. Each protein yielded a distinct distribution (or map) of catabolic activity throughout the body when expressed as percent dose accumulated per gram of tissue. The maps for albumin and transferrin were broadly comparable, whereas those for immunoglobulin G and aglycotransferrin we

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11

Vorobyeva, Anzhelika, Ekaterina Bezverkhniaia, Elena Konovalova, et al. "Radionuclide Molecular Imaging of EpCAM Expression in Triple-Negative Breast Cancer Using the Scaffold Protein DARPin Ec1." Molecules 25, no. 20 (2020): 4719. http://dx.doi.org/10.3390/molecules25204719.

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Efficient treatment of disseminated triple-negative breast cancer (TNBC) remains an unmet clinical need. The epithelial cell adhesion molecule (EpCAM) is often overexpressed on the surface of TNBC cells, which makes EpCAM a potential therapeutic target. Radionuclide molecular imaging of EpCAM expression might permit selection of patients for EpCAM-targeting therapies. In this study, we evaluated a scaffold protein, designed ankyrin repeat protein (DARPin) Ec1, for imaging of EpCAM in TNBC. DARPin Ec1 was labeled with a non-residualizing [125I]I-para-iodobenzoate (PIB) label and a residualizing

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12

Albert, Elvira, Michael Hanus, and Germán Vidal. "A residualizing semantics for the partial evaluation of functional logic programs." Information Processing Letters 85, no. 1 (2003): 19–25. http://dx.doi.org/10.1016/s0020-0190(02)00336-8.

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13

Lucas, Karen L., John W. Baynes, and Suzanne R. Thorpe. "Intracellular processing of residualizing labels in different cell types in vitro." Journal of Cellular Physiology 142, no. 3 (1990): 581–85. http://dx.doi.org/10.1002/jcp.1041420318.

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14

Oroujeni, Maryam, Ayman Abouzayed, Fanny Lundmark, et al. "Evaluation of Tumor-Targeting Properties of an Antagonistic Bombesin Analogue RM26 Conjugated with a Non-Residualizing Radioiodine Label Comparison with a Radiometal-Labelled Counterpart." Pharmaceutics 11, no. 8 (2019): 380. http://dx.doi.org/10.3390/pharmaceutics11080380.

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Radiolabelled antagonistic bombesin analogues are successfully used for targeting of gastrin-releasing peptide receptors (GRPR) that are overexpressed in prostate cancer. Internalization of antagonistic bombesin analogues is slow. We hypothesized that the use of a non-residualizing radioiodine label might not affect the tumour uptake but would reduce the retention in normal organs, where radiopharmaceutical would be internalized. To test this hypothesis, tyrosine was conjugated via diethylene glycol linker to N-terminus of an antagonistic bombesin analogue RM26 to form Tyr-PEG2-RM26. [111In]In

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15

Vorobyeva, Anzhelika, Elena Konovalova, Tianqi Xu, et al. "Feasibility of Imaging EpCAM Expression in Ovarian Cancer Using Radiolabeled DARPin Ec1." International Journal of Molecular Sciences 21, no. 9 (2020): 3310. http://dx.doi.org/10.3390/ijms21093310.

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Epithelial cell adhesion molecule (EpCAM) is overexpressed in 55%–75% of ovarian carcinomas (OC). EpCAM might be used as a target for a treatment of disseminated OC. Designed ankyrin repeats protein (DARPin) Ec1 is a small (18 kDa) protein, which binds to EpCAM with subnanomolar affinity. We tested a hypothesis that Ec1 labeled with a non-residualizing label might serve as a companion imaging diagnostic for stratification of patients for EpCAM-targeting therapy. Ec1 was labeled with 125I using N-succinimidyl-para-iodobenzoate. Binding affinity, specificity, and cellular processing of [125I]I-P

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16

Thorpe, Suzanne R., John W. Baynes, and Zissis C. Chroneos. "The design and application of residualizing labels for studies of protein catabolism." FASEB Journal 7, no. 3 (1993): 399–405. http://dx.doi.org/10.1096/fasebj.7.5.8462781.

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17

Stein, R., A. Basu, S. Chen, D. M. Goldenberg, and M. J. Mattes. "EFFECTS OF RADIOLABELING WITH A RESIDUALIZING FORM OF IODINE ON MAB UPTAKE." Journal of Immunotherapy 16, no. 2 (1994): 166. http://dx.doi.org/10.1097/00002371-199408000-00080.

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18

Wurm, Lee H., and Sebastiano A. Fisicaro. "What residualizing predictors in regression analyses does (and what it does not do)." Journal of Memory and Language 72 (April 2014): 37–48. http://dx.doi.org/10.1016/j.jml.2013.12.003.

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19

McGary, Carl T., Judith Yannariello-Brown, Dennis W. Kim, Tami C. Stinson, and Paul H. Weige. "Degradation and intracellular accumulation of a residualizing hyaluronan derivative by liver endothelial cells." Hepatology 18, no. 6 (1993): 1465–76. http://dx.doi.org/10.1002/hep.1840180628.

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20

Nishikawa, Makiya, Takayuki Nakano, Takayuki Okabe, et al. "Residualizing Indium-111-Radiolabel for Plasmid DNA and Its Application to Tissue Distribution Study." Bioconjugate Chemistry 14, no. 5 (2003): 955–61. http://dx.doi.org/10.1021/bc034032y.

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21

Baynes, John W., Janet L. Maxwell, Kazi M. Rahman, and Suzanne R. Thorpe. "Purification of residualizing glycoconjugate labels for protein by reversed-phase high-pressure liquid chromatography." Analytical Biochemistry 170, no. 2 (1988): 382–86. http://dx.doi.org/10.1016/0003-2697(88)90647-1.

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22

Pruszynski, Marek, Choong Kang, Eftychia Koumarianou, Ganesan Vaidyanathan, and Michael Zalutsky. "d-Amino Acid Peptide Residualizing Agents for Protein Radioiodination: Effect of Aspartate for Glutamate Substitution." Molecules 23, no. 5 (2018): 1223. http://dx.doi.org/10.3390/molecules23051223.

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23

Stein, Rhona, Serengulam V. Govindan, Susan Chen, et al. "Successful therapy of a human lung cancer xenograft using MAb RS7 labeled with residualizing radioiodine." Critical Reviews in Oncology/Hematology 39, no. 1-2 (2001): 173–80. http://dx.doi.org/10.1016/s1040-8428(01)00106-8.

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24

Sharkey, Robert M., Thomas M. Behr, M. Jules Mattes, et al. "Advantage of residualizing radiolabels for an internalizing antibody against the B-cell lymphoma antigen, CD22." Cancer Immunology, Immunotherapy 44, no. 3 (1997): 179–88. http://dx.doi.org/10.1007/s002620050371.

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25

Daugherty, Alan, Michael R. Kilbourn, Carmen S. Dence, Burton E. Sobel, and Suzanne R. Thorpe. "Quantitative assessment of lipoprotein metabolism by positron emission tomography with an 18F-containing residualizing label." International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology 19, no. 3 (1992): 411–16. http://dx.doi.org/10.1016/0883-2897(92)90127-k.

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26

Deforge, Laura E., Mark R. Degalan, Mohamed K. Ruyan, Roger S. Newton, and Raymond E. Counsell. "Comparison of methods for incorporating a radioiodinated residualizing cholesteryl ester analog into low density lipoprotein." International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology 19, no. 7 (1992): 775–82. http://dx.doi.org/10.1016/0883-2897(92)90139-p.

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27

Maxwell, J. L., J. W. Baynes, and S. R. Thorpe. "Inulin-125I-tyramine, an improved residualizing label for studies on sites of catabolism of circulating proteins." Journal of Biological Chemistry 263, no. 28 (1988): 14122–27. http://dx.doi.org/10.1016/s0021-9258(18)68193-1.

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28

Dowd, Marla M., John W. Baynes, and Suzanne R. Thorpe. "Synthesis of N,N-dilactitol ethylenediamine: A versatile spacer for attachment of residualizing labels to protein." Analytical Biochemistry 205, no. 2 (1992): 369–71. http://dx.doi.org/10.1016/0003-2697(92)90451-c.

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29

Lim, Hwisoo, Jae Hun Ahn, Yong Jin Lee, Ganesan Vaidyanathan, Michael Zalutsky, and Choong Mo Kang. "Radioiodination of galacto-bombesin using a residualizing prosthetic agent for imaging of gastrin-releasing peptide receptor." Nuclear Medicine and Biology 126-127 (November 2023): 108634. http://dx.doi.org/10.1016/j.nucmedbio.2023.108634.

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30

Hines, Constance, Jeffrey Kromrey, Joyce Burick Swarzman, Marcia Mann, and Susan Homan. "Teacher Behavior, Task Engagement, and Student Achievement: A Path Analytic Study." Florida Journal of Educational Research 28, no. 1 (1986): 25–40. http://dx.doi.org/10.62798/tbef3560.

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The technique of path analysis was used to test the role of student task engagement as a mediating process variable linking teacher behavior and student achievement in math and social studies classes. Forty teacher-interns and their respective elementary level classes participated in the study. Two measures of teacher behavior and a measure of student task engagement were obtained during lessons from two-week instructional units designed specifically for the study. Achievement was defined as the class mean residualized gain score, residualizing student post- test scores on both content pretest

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31

Feltz, Deborah L., Graig M. Chow, and Teri J. Hepler. "Path Analysis of Self-Efficacy and Diving Performance Revisited." Journal of Sport and Exercise Psychology 30, no. 3 (2008): 401–11. http://dx.doi.org/10.1123/jsep.30.3.401.

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The Feltz (1982) path analysis of the relationship between diving efficacy and performance showed that, over trials, past performance was a stronger predictor than self-efficacy of performance. Bandura (1997) criticized the study as statistically “overcontrolling” for past performance by using raw past performance scores along with self-efficacy as predictors of performance. He suggests residualizing past performance by regressing the raw scores on self-efficacy and entering them into the model to remove prior contributions of self-efficacy imbedded in past performance scores. To resolve this

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32

Flere, Sergej, and Rudi Klanjšek. "Cross-Cultural Insight into the Association between Religiousness and Authoritarianism." Archive for the Psychology of Religion 31, no. 2 (2009): 177–90. http://dx.doi.org/10.1163/157361209x424448.

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The current study investigated the possible existence of a relationship between authoritarianism and religiousness and the possible strength of this potential relationship. The study involved samples from four cultural environments known to differ substantially in terms of religious salience and content: Slovenia (predominantly Catholic), Serbia (predominantly Eastern Orthodox), Bosnia and Herzegovina (predominantly Muslim), and the United States (predominantly Protestant). Religiousness was assessed by way of religious orientation (including intrinsic and extrinsic orientation) as proposed by

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33

Lindbo, Sarah, Javad Garousi, Bogdan Mitran, et al. "Radionuclide Tumor Targeting Using ADAPT Scaffold Proteins: Aspects of Label Positioning and Residualizing Properties of the Label." Journal of Nuclear Medicine 59, no. 1 (2017): 93–99. http://dx.doi.org/10.2967/jnumed.117.197202.

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34

Ord, J. M., J. Hasapes, A. Daugherty, S. R. Thorpe, S. R. Bergmann, and B. E. Sobel. "Imaging of thrombi with tissue-type plasminogen activator rendered enzymatically inactive and conjugated to a residualizing label." Circulation 85, no. 1 (1992): 288–97. http://dx.doi.org/10.1161/01.cir.85.1.288.

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35

Mattes, M. Jules, Lisa B. Shih, Serengulam V. Govindan, et al. "The advantage of residualizing radiolabels for targeting B-cell lymphomas with a radiolabeled anti-CD22 monoclonal antibody." International Journal of Cancer 71, no. 3 (1997): 429–35. http://dx.doi.org/10.1002/(sici)1097-0215(19970502)71:3<429::aid-ijc21>3.0.co;2-9.

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36

Mukai, Takahiro, Shinji Namba, Yasushi Arano, et al. "Synthesis and evaluation of a monoreactive DOTA derivative for indium-111-based residualizing label to estimate protein pharmacokinetics." Journal of Pharmacy and Pharmacology 54, no. 8 (2002): 1073–81. http://dx.doi.org/10.1211/002235702320266226.

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37

Zhou, Zhengyuan, Ganesan Vaidyanathan, Darryl McDougald, et al. "Fluorine-18 Labeling of the HER2-Targeting Single-Domain Antibody 2Rs15d Using a Residualizing Label and Preclinical Evaluation." Molecular Imaging and Biology 19, no. 6 (2017): 867–77. http://dx.doi.org/10.1007/s11307-017-1082-x.

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38

Lim, Shen Jean, Miriam Aguilar-Lopez, Christine Wetzel, et al. "The Effects of Genetic Relatedness on the Preterm Infant Gut Microbiota." Microorganisms 9, no. 2 (2021): 278. http://dx.doi.org/10.3390/microorganisms9020278.

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The preterm infant gut microbiota is influenced by environmental, endogenous, maternal, and genetic factors. Although siblings share similar gut microbial composition, it is not known how genetic relatedness affects alpha diversity and specific taxa abundances in preterm infants. We analyzed the 16S rRNA gene content of stool samples, ≤ and >3 weeks postnatal age, and clinical data from preterm multiplets and singletons at two Neonatal Intensive Care Units (NICUs), Tampa General Hospital (TGH; FL, USA) and Carle Hospital (IL, USA). Weeks on bovine milk-based fortifier (BMF) and weight gain

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39

Pruszynski, Marek, Eftychia Koumarianou, Ganesan Vaidyanathan, Satish Chitneni, and Michael R. Zalutsky. "D-amino acid peptide residualizing agents bearing N-hydroxysuccinimido- and maleimido-functional groups and their application for trastuzumab radioiodination." Nuclear Medicine and Biology 42, no. 1 (2015): 19–27. http://dx.doi.org/10.1016/j.nucmedbio.2014.08.007.

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40

Daugherty, A., S. R. Thorpe, L. G. Lange, B. E. Sobel, and G. Schonfeld. "Loci of catabolism of beta-very low density lipoprotein in vivo delineated with a residualizing label, 125I-dilactitol tyramine." Journal of Biological Chemistry 260, no. 27 (1985): 14564–70. http://dx.doi.org/10.1016/s0021-9258(17)38605-2.

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41

Zhang, Wenting, Wei Fan, Brendan M. Ottemann, Sameer Alshehri, and Jered C. Garrison. "Development of Improved Tumor-Residualizing, GRPR-Targeted Agents: Preclinical Comparison of an Endolysosomal Trapping Approach in Agonistic and Antagonistic Constructs." Journal of Nuclear Medicine 61, no. 3 (2019): 443–50. http://dx.doi.org/10.2967/jnumed.119.231282.

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42

Govindan, Serengulam V., Rhona Stein, Zhengxing Qu, et al. "Preclinical Therapy of Breast Cancer with a Radioiodinated Humanized Anti-EGP-1 Monoclonal Antibody: Advantage of a Residualizing Iodine Radiolabel." Breast Cancer Research and Treatment 84, no. 2 (2004): 173–82. http://dx.doi.org/10.1023/b:brea.0000018417.02580.ef.

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43

Stein, Rhona, Serengulam V. Govindan, Marianne Hayes, et al. "Advantage of a Residualizing Iodine Radiolabel in the Therapy of a Colon Cancer Xenograft Targeted with an Anticarcinoembryonic Antigen Monoclonal Antibody." Clinical Cancer Research 11, no. 7 (2005): 2727–34. http://dx.doi.org/10.1158/1078-0432.ccr-04-2100.

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44

Tolmachev, V., A. Bruskin, S. Sjöberg, J. Carlsson, and H. Lundqvist. "Preparation, radioiodination and in vitro evaluation of a nido-carborane-dextran conjugate, a potential residualizing label for tumor targeting proteins and peptides." Journal of Radioanalytical and Nuclear Chemistry 261, no. 1 (2004): 107–12. http://dx.doi.org/10.1023/b:jrnc.0000030942.76919.6b.

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45

Deyev, Sergey M., Tianqi Xu, Yongsheng Liu, et al. "Influence of the Position and Composition of Radiometals and Radioiodine Labels on Imaging of Epcam Expression in Prostate Cancer Model Using the DARPin Ec1." Cancers 13, no. 14 (2021): 3589. http://dx.doi.org/10.3390/cancers13143589.

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The epithelial cell adhesion molecule (EpCAM) is intensively overexpressed in 40–60% of prostate cancer (PCa) cases and can be used as a target for the delivery of drugs and toxins. The designed ankyrin repeat protein (DARPin) Ec1 has a high affinity to EpCAM (68 pM) and a small size (18 kDa). Radiolabeled Ec1 might be used as a companion diagnostic for the selection of PCa patients for therapy. The study aimed to investigate the influence of radiolabel position (N- or C-terminal) and composition on the targeting and imaging properties of Ec1. Two variants, having an N- or C-terminal cysteine,

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46

Moldoveanu, Z., J. M. Epps, S. R. Thorpe, and J. Mestecky. "The sites of catabolism of murine monomeric IgA." Journal of Immunology 141, no. 1 (1988): 208–13. http://dx.doi.org/10.4049/jimmunol.141.1.208.

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Abstract The tissue sites of monomeric IgA (mIgA) catabolism were determined in a BALB/c mouse model. Mouse mIgA myeloma proteins were labeled either by direct iodination or by coupling the residualizing label, dilactitol-125I-tyramine (125I-DLT) to the proteins; catabolites from protein labeled with 125I-DLT accumulate at the site of protein degradation, allowing identification of the tissue and cellular sites involved in catabolism of the protein. The circulating half-lives of 125I- and 125I-DLT-mIgA were the same. The distribution of radioactivity in tissues was measured at 1, 3, 24, and 96

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47

Vaidyanathan, Ganesan, Emmanuelle Jestin, Tove Olafsen, Anna M. Wu, and Michael R. Zalutsky. "Evaluation of an anti-p185HER2 (scFv-CH2-CH3)2 fragment following radioiodination using two different residualizing labels: SGMIB and IB-Mal-d-GEEEK." Nuclear Medicine and Biology 36, no. 6 (2009): 671–80. http://dx.doi.org/10.1016/j.nucmedbio.2009.04.002.

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48

Meeh, L. A., J. J. H. Ackerman, S. R. Thorpe та A. Daugherty. "Quantification of the accumulation and degradation of β-very-low-density lipoproteins in vivo using a 19F-containing residualizing label and n.m.r. spectroscopy". Biochemical Journal 286, № 3 (1992): 785–92. http://dx.doi.org/10.1042/bj2860785.

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beta-Very-low-density lipoproteins (beta-VLDL)O were conjugated to the 19F-containing residualizing label, NN-dilactitol-3,5-bis(trifluoromethyl)benzylamine (DLBA), to determine whether the metabolism of this lipoprotein fraction could be characterized in vivo with n.m.r. spectroscopy. Solution state 19F high-resolution n.m.r. spectroscopy of DLBA-beta-VLDL, containing either intact apoproteins or selectively enzymically digested products, demonstrated that the extent of degradation could be distinguished by differences in spin-spin relaxation times (T2 times). DLBA-beta-VLDL was injected intr

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49

Zhou, Zhengyuan, Satish K. Chitneni, Nick Devoogdt, Michael R. Zalutsky, and Ganesan Vaidyanathan. "Fluorine-18 labeling of an anti-HER2 VHH using a residualizing prosthetic group via a strain-promoted click reaction: Chemistry and preliminary evaluation." Bioorganic & Medicinal Chemistry 26, no. 8 (2018): 1939–49. http://dx.doi.org/10.1016/j.bmc.2018.02.040.

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Ye, Qiaofeng, and Idan Shalev. "CAUSALITY-INFORMED REPRODUCTIVE CLOCKS REFLECT IMPACT OF CHILDHOOD MALTREATMENT ON EPIGENETIC AGING." Innovation in Aging 8, Supplement_1 (2024): 701. https://doi.org/10.1093/geroni/igae098.2288.

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Abstract:

Abstract Machine-learning-based epigenetic clocks have been widely used to predict an organism’s age, pace of aging, and mortality. Here, we report the development of two novel reproductive clocks to reflect biological aging relative to menarche (MenarcheClock) or menopause (MenopauseClock) in females. First, Mendelian randomization was employed to identify CpG sites with significant causal effects on age at menarche or menopause. Next, models of MenarcheClock and MenopauseClock were trained using elastic net regression with array-measured DNA methylation of buccal cells from 540 females aged

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