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1

Hiscox, Stephen, Julia Gee, and Robert I. Nicholson, eds. Therapeutic Resistance to Anti-Hormonal Drugs in Breast Cancer. Dordrecht: Springer Netherlands, 2009. http://dx.doi.org/10.1007/978-1-4020-8526-0.

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2

Arrow, Kenneth Joseph, Hellen Gelband, and Claire Panosian. Saving lives, buying time: Economics of malaria drugs in an age of resistance. Edited by Institute of Medicine (U.S.). Committee on the Economics of Antimalarial Drugs and NetLibrary Inc. Washington, D.C: National Academies Press, 2004.

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3

Julia, Gee, Nicholson Robert I, and SpringerLink (Online service), eds. Therapeutic Resistance to Anti-Hormonal Drugs in Breast Cancer: New Molecular Aspects and their Potential as Targets. Dordrecht: Springer Netherlands, 2009.

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4

Enzybiotics: Antibiotic enzymes as drugs and therapeutics. Hoboken, N.J: John Wiley & Sons, 2010.

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5

Chŏng, Yun-hŭi. Chʻuksan hwanʼgyŏng ŭi naesŏng chosa mit yŏnghyang pʻyŏngka =: A study on antibiotic resistance and effect assessment in domestic livestock environment. [Seoul]: Sikpʻum Ŭiyakpʻum Anjŏnchʻŏng, 2007.

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6

Peters, Wallace. Chemotherapy and drug resistance in malaria. 2nd ed. London: Academic Press, 1987.

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7

Policies and incentives for promoting innovation in antibiotic research. [S.l.]: European Observatory on Health Systems and Policies, 2010.

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8

Arora, Gunjan, Andaleeb Sajid, and Vipin Chandra Kalia, eds. Drug Resistance in Bacteria, Fungi, Malaria, and Cancer. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-48683-3.

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9

Antimicrobial drug resistance. [Totowa, N.J.]: Humana Press, 2009.

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10

Global Project on Anti-tuberculosis Drug Resistance Surveillance 1994-1997. Anti-tuberculosis drug resistance in the world. Geneva: Global Tuberculosis Programme, WHO, 1997.

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11

World Health Organization (WHO). The use of Artemisinin and its derivatives as ant-malarial drugs: Report of a Joint CTD/DMP/TDR Informal Consultation. Geneva: World Health Organization, 1998.

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12

Inc, ebrary, ed. Chemical analysis of antibiotic residues in food. Hoboken, N.J: Wiley & Sons, 2012.

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13

Oduor, Jacob. Evaluating the impact of microfranchising the distribution of anti-malaria drugs in Kenya on malaria mortality and morbidity. Nairobi, Kenya: Kenya Institute for Public Policy Research and Analysis, 2010.

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14

Matteo, Zignol, and WHO/IUATLD Global Project on Anti-tuberculosis Drug Resistance Surveillance., eds. Anti-tuberculosis drug resistance in the world: Fourth global report : the World Health Organization/International Union Against Tuberculosis and Lung Disease (WHO/UNION) Global Project on Anti-Tuberculosis Drug Resistance Surveillance, 2002-2007. Geneva, Switzerland: World Health Organization, 2008.

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15

Wright, Abigail. Anti-tuberculosis drug resistance in the world: Fourth global report : the World Health Organization/International Union Against Tuberculosis and Lung Disease (WHO/UNION) Global Project on Anti-Tuberculosis Drug Resistance Surveillance, 2002-2007. Geneva, Switzerland: World Health Organization, 2008.

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16

Antibiotics and antibiotic resistance. Hoboken, N.J: Wiley, 2011.

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17

Csizmadia, Emanuel. Antimalarial drugs: Costs, safety and efficacy. New York: Nova Biomedical Books, 2009.

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18

Ministry of Agriculture, Fisheries and Food. A review of antimicrobial resistance in the food chain: A technical report for MAFF. London: GB MAFF, 1998.

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19

Bonilla, Adriel R. Antibiotic resistance: Causes and risk factors, mechanisms and alternatives. New York: Nova Science Publishers, 2009.

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20

Staines, Henry M. Treatment and Prevention of Malaria: Antimalarial Drug Chemistry, Action and Use. Basel: Springer Basel, 2012.

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21

Chŏng, Sŏk-hun. Hangsaengje naesŏng yujŏnchʻe yŏnʼgu =: Analysis of antimicrobial resistance gene. [Seoul]: Sikpʻum Ŭiyakpʻum Anjŏnchʻŏng, 2007.

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22

Emami, Saeed. New quinolones with potential anti-MRSA activity. Hauppauge, N.Y: Nova Science, 2009.

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23

C, Crabbe M. James, ed. Bacteria and anti-bacterical agents. Oxford: Spektrum, 1996.

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24

Gould, Ian M. Antibiotic policies: Controlling hospital acquired infection. New York: Springer, 2011.

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25

Anup, Malani, ed. Extending the cure: Policy responses to the growing threat of antibiotic resistance. Washington, DC: Resources for the Future, 2007.

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26

Emergence of the superbug: Antimicrobial resistance in the United States : hearing of the Committee on Health, Education, Labor, and Pensions, United States Senate, One Hundred Tenth Congress, second session, on examining the public health impacts of antimicrobial resistant bacterial infections in the United States, focusing on current antimicrobials and continued development of new solutions for the future protection against infectious diseases, June 24, 2008. Washington: U.S. G.P.O., 2010.

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27

Tackling antibiotic resistance from a food safety perspective in Europe. Copenhagen: World Health Organization, 2011.

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28

Russell, A. D. Understanding antibacterial action and resistance. Chichester, West Sussex: Ellis Horwood, 1990.

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29

Lappé, Marc. When antibiotics fail: Restoring the ecology of the body. Berkeley, Calif: North Atlantic Books, 1986.

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30

Lappé, Marc. When antibiotics fail: Restoring the ecology of the body. Berkeley, Calif: North Atlantic Books, 1995.

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31

Rosenthal, MD Philip J. Antimalarial Chemotherapy: Mechanisms of Action, Resistance, and New Directions in Drug Discovery. Humana Press, 2010.

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32

(Editor), Kenneth J. Arrow, Claire B. Panosian (Editor), and Hellen Gelband (Editor), eds. Saving Lives, Buying Time: Economics of Malaria Drugs in an Age of Resistance. National Academy Press, 2004.

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33

Villa, Tomas G., and Patricia Veiga Crespo. Enzybiotics: Antibiotic Enzymes As Drugs and Therapeutics. Wiley & Sons, Incorporated, John, 2010.

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34

(WHO), World Health Organization. Antimicrobial Resistance: Global Report on Surveillance. WHO Regional Office for the Western Pacific, 2014.

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35

The Evolving Threat Of Antimicrobial Resistance Options For Action. World Health Organization, 2012.

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36

Principles Of Judicious Use Of Antimicrobial Agents: A Compendium for the Health Care Professional. AMERICAN ACADEMY OF PEDIATRICS, 1998.

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37

Hiscox, Stephen, Julia Gee, and Robert I. Nicholson. Therapeutic Resistance to Anti-hormonal Drugs in Breast Cancer: New Molecular Aspects and their Potential as Targets. Hiscox Stephen Gee Julia Nicholson Robert I, 2010.

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38

Enzybiotics: Antibiotic enzymes as drugs and therapeutics. Hoboken, N.J: John Wiley & Sons, 2010.

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39

(Editor), Ian M. Gould, and J.W. van der Meer (Editor), eds. Antibiotic Policies: Theory and Practice. Springer, 2004.

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40

Organization, World Health, ed. WHO model prescribing information: Drugs used in bacterial infections. Geneva: World Health Organization, 2001.

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41

Kalia, Vipin Chandra, Gunjan Arora, and Andaleeb Sajid. Drug Resistance in Bacteria, Fungi, Malaria, and Cancer. Springer, 2018.

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42

World Health Organization (WHO). Anti-tuberculosis Drug Resistance Surveillance (The WHO/IUATLD Global Project on Anti-tuberculosis Drug Resistance Surveillance). World Health Organization, 1998.

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43

Sobel, Jack D., Douglas L. Mayers, Keith S. Kaye, Marc Ouellette, and Dror Marchaim. Antimicrobial Drug Resistance: Mechanisms of Drug Resistance, Volume 1. Springer, 2017.

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44

Sobel, Jack D., Douglas L. Mayers, Keith S. Kaye, Marc Ouellette, and Dror Marchaim. Antimicrobial Drug Resistance: Mechanisms of Drug Resistance, Volume 1. Springer, 2018.

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45

Organization, World Health. Anti-Tuberculosis Drug Resistance in the World. World Health Organization, 2000.

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46

Abdel, Aziz Mohamed, and WHO/IUATLD Global Project on Anti-tuberculosis Drug Resistance Surveillance., eds. Anti-tuberculosis drug resistance in the world: Third global report : the WHO/IUATLD Global Project on Anti-tuberculosis Drug Resistance Surveillance, 1999-2002. Geneva: World Health Organization, 2004.

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47

Jian, Wang, Jack F. Kay, and James D. MacNeil. Chemical Analysis of Antibiotic Residues in Food. Wiley & Sons, Incorporated, John, 2011.

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48

Thursfield, Rebecca, Chris Orchard, Rosanna Featherstone, and Jane C. Davies. Future treatments. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780198702948.003.0013.

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Abstract:
There are only a relatively limited armoury of drugs, the majority of which are aimed at downstream symptoms of cystic fibrosis. Therapies targeting the basic defect in CF as well as continued availability of more conventional drugs are required. Progress in gene therapy has been limited by the significant barriers to gene transfer of the CF lung, but the UK is hosting a large repeated dose trial of nebulized non-viral gene therapy designed around clinically meaningful outcomes. The UK CF Gene Therapy Consortium is also seeking to develop a promising modified lentiviral approach, although this is some years off. Perhaps the exciting development of recent decades has come from small molecule CFTR modulators, driven by an understanding of basic pathophysiological mechanisms. Ivacaftor is the first drug to be licensed, having proved itself highly clinically efficacious in patients with the class-3 gating mutation G551D. The trial pipeline seeks to expand indications for this and to explore the potential of Phe508del correctors. Finally, a number of anti-inflammatory and anti-infective strategies are being pursued. The emerging global problem of antibiotic resistance is leading to exciting alternatives such as biofilm disruption and bacteriophage to be explored.
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49

Antibiotic Resistance. Springer, 2012.

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50

Anti-Tuberc, Who Iuatld Global Project on. Anti-Tuberculosis Drug Resistance in the World: Third Global Report. World Health Organization, 2005.

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