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Dissertations / Theses on the topic 'Resistance to platinum'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Stordal, Britta Kristina. "Regrowth resistance in platinum-drug resistant small cell lung cancer cells." Bill Walsh Cancer Research Laboratories, Royal North Shore Hospital and The University of Sydney, 2007. http://hdl.handle.net/2123/2467.

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Doctor of Philosophy (PhD)<br>The H69CIS200 cisplatin-resistant and H69OX400 oxaliplatin-resistant cell lines developed as part of this study, are novel models of low-level platinum resistance. These resistant cell lines do not have common mechanisms of platinum resistance such as increased expression of glutathione or decreased platinum accumulation. Rather, these cell lines have alterations in their cell cycle allowing them to proliferate rapidly post drug treatment in a process known as ‘regrowth resistance’. This alteration in cell cycle control has come at the expense of DNA repair capaci

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Stordal, Britta. "Regrowth resistance in platinum-drug resistant small cell lung cancer cells." Connect to full text, 2006. http://hdl.handle.net/2123/2467.

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Thesis (Ph. D.)--University of Sydney, 2007.<br>Title from title screen (viewed 10 June 2008). Submitted in fulfilment of the requirements for the degree of Doctor of Philosophy to the Discipline of Medicine, Faculty of Medicine. Degree awarded 2007; thesis submitted 2006. Includes bibliographical references. Also available in print form.

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3

Yiu, Yin-ling Elaine, and 姚燕玲. "Corrosion resistance of iron-platinum dental magnets." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2002. http://hub.hku.hk/bib/B31954261.

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4

Yiu, Yin-ling Elaine. "Corrosion resistance of iron-platinum dental magnets." Hong Kong : University of Hong Kong, 2002. http://sunzi.lib.hku.hk/hkuto/record.jsp?

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5

Newton, C. "Clinical resistance to platinum chemotherapy in ovarian cancer." Thesis, University College London (University of London), 2009. http://discovery.ucl.ac.uk/1446312/.

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Platinum drugs are the most active agents in ovarian cancer. Their cytotoxicty results from DNA crosslinking. High tumour response rates are seen, but 80 % of patients relapse. Major mechanisms of platinum resistance in patients remain to be established. We have studied DNA interstrand crosslinking and its repair in response to ex vivo treatment with cisplatin in forty patients with ovarian cancer using the single cell gel electrophoresis (comet) assay. Tumour cells from resected tumours or tumour and mesothelial cells from ascites were obtained from chemonaive patients and those relapsing aft

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6

O'Neill, Ciaran Francis. "Cellular mechanisms of sensitivity and resistance to platinum agents." Thesis, Institute of Cancer Research (University Of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.324883.

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7

Holford, Jeffrey. "Circumvention of tumour resistance to the platinum-based anticancer drug cisplatin." Thesis, Institute of Cancer Research (University Of London), 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.267860.

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8

Graham, Janet S. "DNA methylation changes associated with acquired platinum resistance in ovarian cancer." Thesis, Imperial College London, 2011. http://hdl.handle.net/10044/1/9000.

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Despite high responses to initial chemotherapy most patients with ovarian cancer (OC) relapse and inevitably die from their disease. Aberrant DNA methylation is frequently seen in ovarian tumours and may provide biomarkers of clinical outcome or insight into mechanisms of chemoresistance. We firstly performed Differential Methylation Hybridisation (DMH) to identify loci that gained methylation between 34 matched cisplatin sensitive and resistant OC tumour cell lines. Differentially methylated loci identified were further validated by Methylation Specific PCR (MSP) and bisulphite pyrosequencing

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9

Abd, Latip Normala. "LARP1, an mRNA binding protein involved in cancer progression & platinum resistance." Thesis, Imperial College London, 2012. http://hdl.handle.net/10044/1/39469.

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LARP1 is a novel protein that was first identified in Drosophila where it was shown to be required for embryogenesis, spermatogenesis and cell cycle progression. LARP1 is 'La-related protein' by virtue of its La domain and RRM motif, common to all La proteins. Unlike the other members of LARP family, LARP1 also carries a conserved C terminal domain; the tandem DM15 repeat-containing region which is of unknown function, although it has been proposed to be involved in mRNA binding. LARP1 has been shown previously in our lab to regulate the translation of a subset of mRNAs that encode cytoskeleta

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Mohn, Carina [Verfasser]. "Relevance of glutathione and MRP-mediated efflux for platinum resistance / Carina Mohn." Bonn : Universitäts- und Landesbibliothek Bonn, 2013. http://d-nb.info/1044971827/34.

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11

Zeng, Xiang. "Phosphorylation of STAT1 Serine 727 Enhances Platinum Resistance in Uterine Serous Carcinoma." Kyoto University, 2019. http://hdl.handle.net/2433/245312.

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12

Benvenuto, Giuseppe. "A bioinformatic approach to define transcriptome alterations in platinum resistance ovarian cancers." Doctoral thesis, Università degli studi di Padova, 2019. http://hdl.handle.net/11577/3424723.

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Epithelial ovarian cancer (EOC) is the most lethal gynecological malignancy due to its diagnosis at advanced stages, when the disease has already spread beyond the ovaries. EOC is generally sensitive to first line chemotherapy, and the vast majority of patients respond to platinum (Pt)-based therapy after debulking surgery. Unfortunately, more than 80% of Pt-responsive patients relapse with a disease that progressively becomes Pt-resistant. Based mainly on clinical evidence, the process by which disease relapses is still poorly understood. The aim is to identify biomarkers of sensitivity to

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13

GAMBELLI, ALICE. "ITGA6 is a key molecule in driving metastatization of platinum resistant epithelial ovarian cancer." Doctoral thesis, Università degli Studi di Trieste, 2022. http://hdl.handle.net/11368/3014977.

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Epithelial ovarian cancer (EOC) is a relatively rare disease usually diagnosed in advanced stages (III and IV stage). Standard of care includes radical surgery followed by platinum-based chemotherapy. Yet, 15% to 30% of EOC patients have a primary platinum-resistant or refractory disease and more than 70% of originally platinum-sensitive advanced stages patients will develop a resistant disease disseminated in the abdomen and pelvis. For these reasons, the net five-year survival by stage is only of 26% and 13% for stage III and IV, respectively. The resistance to chemotherapy is one of the maj

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14

Chen, Michelle. "Platinum resistance in ovarian cancer : a molecular analysis of the P13K/AKT pathway." Thesis, Imperial College London, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.530449.

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15

Webb, Timothy A. "Celecoxib enhances sorafenib/sildenafil lethality in cancer cells and reverts platinum chemotherapy resistance." VCU Scholars Compass, 2016. http://scholarscompass.vcu.edu/etd/4084.

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The present studies sought to determine whether the lethality of the drug combination [sorafenib + sildenafil] could be enhanced by the anti-inflammatory agent celecoxib, using ovarian cancer and other tumor cell lines as models. Also, in a dose dependent fashion celecoxib enhanced [sorafenib + sildenafil] lethality in multiple ovarian cancer cell lines. In a dose dependent fashion celecoxib enhanced the ability of [sorafenib + sildenafil] to reduce expression of multiple chaperone proteins in parallel with lower levels of the drug efflux pumps ABCB1 and ABCG2. Over-expression of GRP78 and HSP

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16

Espling, Maria. "Copper-transporting proteins and their interactions with platinum-based anticancer substances." Doctoral thesis, Umeå universitet, Kemiska institutionen, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-80717.

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Cisplatin (CisPt) is an important drug that is used against various cancers, including testicular, ovarian, lung, head, and neck cancer. However, its effects are limited by cellular resistance. The resistance is believed to be multifactorial, and may be mediated to varying degree by multiple systems in cells, one of the proposed systems being the copper (Cu) transporting system. The Cu-importer Ctr1 has proven importance for cellular sensitivity to CisPt by regulating its influx, while the Golgi-localized Cu-ATP:ases ATP7A/B can putatively mediate CisPt efflux and/or drug sequestration. Atox1

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Popovic, Predrag. "Cisplatin resistance in nonsmall cell lung cancer: Role of platinum accumulation and cell membranes." Thesis, University of Ottawa (Canada), 1994. http://hdl.handle.net/10393/9662.

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A cisplatin resistant cell line named E-8/0.7 was derived from the nonsmall cell lung cancer HTB 56 cell line. According to IC$\sb{50}$ estimations, E-8/0.7 cells were approximately 7.7 times more resistant to cisplatin than were HTB 56 cells. Uptake of cisplatin 100 $\mu$M over 1 hour was measured by atomic absorption spectrophotometry, and showed around a 30% lower uptake in E-8/0.7 cells compared to HTB 56 cells. Barotropic behaviour was analyzed by pressure tuning infrared spectroscopy. In the CH symmetric stretching region, we found a lower break point (and consequently lower membrane flu

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18

Nicolson, Marianne Coutts. "Platinum chemotherapy : investigation of cellular resistance mechanisms and early development of an oral analogue." Thesis, University of Edinburgh, 1996. http://hdl.handle.net/1842/20710.

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In this thesis, the results are presented of experiments performed to investigate the mechanisms of platinum resistance in the murine L1210 leukaemia cell line <I>in vitro</I>. In addition, platinum resistant L1210 variants have been developed and these cell lines are also studied. In addition to allowing characterisation of the resistant cells, murine and human tumour models are invaluable in screening novel compounds for antitumour activity. In the second part of the thesis, the L1210 sensitive and resistant cell lines are employed along with human ovarian cancer cell lines <I>in vitro</I> t

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Petchpong, P. "Quantitative impurities effects on temperatures of tin and aluminium fixed-point cells." Thesis, Brunel University, 2009. http://bura.brunel.ac.uk/handle/2438/3984.

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The International Temperature Scale of 1990 (ITS-90) defines the present S.I.(“System International”) means of measuring temperature. The ITS-90 uses the freezing points of metals to define temperature fixed points. It also uses long-stemplatinum resistance thermometers to interpolate between the fixed points from 660 °Cdown to 84 K (if one includes the Argon triple point). Impurities are a major source of uncertainty in the fixed point temperature (of the order of 1 mK). And a better understanding of the impurity effect is required to improve top-level metrologicalthermometry. Most historical

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20

Anwar, MD Sheikh. "Natural compounds in combination with platinum drugs administered to ovarian cancer models towards synergistic outcomes." Thesis, The University of Sydney, 2018. http://hdl.handle.net/2123/18714.

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Ovarian cancer is known as one of the dreaded diseases due to its low five years’ survival, acquired drug resistance and recurrence. It is treated mainly by platinum drugs given alone or in combination with paclitaxel. However, problems of drug resistance that is often acquired still remain. While resistance to platinum drugs at the molecular level can be due to overexpression of nuclear factor kappa B (NF-κB) and protein kinase B (AKT/PKB) pathways, it is believed that phytochemicals and other natural compounds can inhibit expression of NF-κB and AKT/PKB. This study aimed to apply binary comb

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21

Cheraghchi, Bashi Astaneh Azadeh. "The effect of AKT pathway inhibition on reversal of platinum resistance in ovarian cancer : a translational approach." Thesis, Imperial College London, 2014. http://hdl.handle.net/10044/1/39596.

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Dysregulation of the phosphotidylinositol-3-kinase (PI3-kinase)/AKT signalling pathway is one of the most frequent mutational events in various human malignancies, including ovarian cancer. Increased PI3K/AKT activity in malignant cells is associated with resistance to chemotherapeutic agents. GSK2141795 is a potent pan-AKT kinase inhibitor, being developed for ovarian and other cancers. The aim of the present study was to evaluate the ability of GSK2141795 to restore platinum sensitivity to platinum-resistant ovarian cancer cell lines. Effective pharmacodynamic (PD) biomarkers are critical fo

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22

Shamai, Pamela Win. "Repair of DNA interstrand crosslinks as a mechanism of clinical resistance to platinum drugs in ovarian cancer." Thesis, University College London (University of London), 2006. http://discovery.ucl.ac.uk/1445841/.

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Despite improvements in tumour response and survival following platinum based therapy in ovarian cancer, both intrinsic and acquired drug resistance remain a significant problem. Mechanisms of acquired drug resistance have been studied extensively in ovarian cancer cells in culture following repeated drug exposure however the relevance of these mechanisms to the clinical situation still needs to be clearly defined. Studies in clinical material have been hampered by the unavailability of sensitive methods to detect the critical drug-induced effects in individual cells. Recently, a modification

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23

COSTA, ALICE. "Dissecting the role of G9a/GLP histone methyltransferases in Platinum-resistant ovarian cancer." Doctoral thesis, Università degli Studi di Trieste, 2021. http://hdl.handle.net/11368/2988156.

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Epithelial Ovarian Cancer (EOC) is the most aggressive gynecological malignancy, mainly due to the advanced stage at diagnosis and the development of drug-resistant recurrences. Epigenetic modifications, such as histone methylation/acetylation, are emerging as key regulators of tumor growth and response to therapies. To verify if they are also involved in the onset of drug re-sistance in EOC, we performed a high-throughput Epigenetic Modifiers (EMs)-based screening using four different models of EOC isogenic Platinum-Resistant (PT-Res) cells. The screening identified G9a/GLP histone methyltran

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Sanders, Lara Clare. "Investigation of platinum drug mode of action and resistance using yeast and human neuroblastoma cells as model systems." Thesis, University of Kent, 2017. https://kar.kent.ac.uk/61254/.

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The platinum-based cytotoxic chemotherapeutics cisplatin, carboplatin, and oxaliplatin are widely used as anti-cancer drugs, but their efficacy is limited by the occurrence of resistance. The mechanisms of actions of these drugs as well as the mechanisms underlying resistance (formation) to platinum drugs remain incompletely understood. More knowledge is required to develop more effective therapies. In this study, we used yeast cells and neuroblastoma cell lines to investigate the mode of action and resistance to platinum drugs. First, we screened a Saccharomyces cerevisiae transcription facto

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25

Franke, Christina E. "Tobacco Mosaic Virus Nanocarrier for Restored Cisplatin Efficacy in Platinum-Resistant Ovarian Cancer." Case Western Reserve University School of Graduate Studies / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=case1493810190306879.

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26

Balcells, Nadal Cristina. "The supramolecular organization of cancer metabolism: From macromolecular crowding to metabolic reprogramming underlying cancer metastasis and drug resistance." Doctoral thesis, Universitat de Barcelona, 2019. http://hdl.handle.net/10803/668321.

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Metastasis and drug resistance represent the two main causes of therapeutic failure in oncology. In the present dissertation, the interplay between them has been interrogated using metabolomics, systems biology and biophysical approaches, in an attempt to find common phenotypic adaptations and metabolic vulnerabilities of metastatic and resistant cancer cells, potentially exploitable in novel combination therapies. The obtained results unveil that highly metastatic e-CSC phenotypes of CRPC present particular metabolic vulnerabilities that can potentially lead to establishing putative biomark

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27

El, Hefni Baligh Hassan. "Etalonnage dynamique des capteurs de temperature en milieu liquide." Paris, ENSAM, 1987. http://www.theses.fr/1987ENAM0010.

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28

Bonham, Clare. "The development of accurate stagnation temperature probes for gas turbine applications." Thesis, Loughborough University, 2015. https://dspace.lboro.ac.uk/2134/19526.

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During gas turbine development testing, measurements of the gas-path stagnation temperature are used to characterise the engine running condition and establish individual engine component performance. These measurements are typically acquired using passively ventilated thermocouple probes, which are capable of achieving absolute stagnation temperature uncertainties of approximately 0.5 %. Historically, this measurement accuracy has been considered adequate to evaluate gains in turbomachinery efficiency. However, realisable turbomachinery efficiency gains have recently become sufficiently small

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Almoyad, Muhammad. "Synergism from combination of targeted therapy and phytochemicals in colorectal cancer." Thesis, The University of Sydney, 2018. http://hdl.handle.net/2123/18161.

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Colorectal cancer is the second most common cancer in women and third in men, accounting for 9.7 % of all cancers incidence. Oxaliplatin is a platinum-based anticancer drug used typically in combination with folinic acid and 5-fluorouracil for treatment against colorectal cancer. However, numerous side effects such as nausea and vomiting, GI toxicity, anaemia, immunodeficiency, ototoxicity, nephrotoxicity, and neurotoxicity are associated with its use. These can be decreased by lowering dose of oxaliplatin. Phytochemicals that can act as antioxidants have been used by people in treatment again

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Necib, Ammour Ouarda. "Effect of platinum group metal (PGM) additions on the stress corrosion cracking resistance of type 304 stainless steel in pressurised water reactors." Thesis, University of Manchester, 2010. https://www.research.manchester.ac.uk/portal/en/theses/effect-of-platinum-group-metal-pgm-additions-on-the-stress-corrosion-cracking-resistance-of-type-304-stainless-steel-in-pressurised-water-reactors(d7578933-6268-4fe8-819e-7b9b066f5c2e).html.

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In pressurised water reactors (PWRs), hydrogen overpressure is used to keep the corrosion potential below the threshold for onset of intergranular stress corrosion cracking (IGSCC) in type 304 SS. However, some regions may contain higher oxygen levels resulting in an increase in the potential. These 'dead space' regions are difficult to access and during refuelling; oxygen may become trapped in these locations. The objective of this study was to investigate the influence of PGM additions on IGSCC susceptibility of type 304 stainless steels (SS) in the sensitised state within PWRs. The work pre

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Van, Schoor Abraham Michael. "Using electrical resistance tomography (ERT) and induced polarisation (IP) tomography to map potholes and iron-rich ultramafic pegmatite bodies in South African platinum mines." Thesis, Lancaster University, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.539647.

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32

KARIMBAYLI, JAVAD. "Dissecting the role of CDK17 in Epithelial Ovarian Cancer." Doctoral thesis, Università degli Studi di Trieste, 2022. http://hdl.handle.net/11368/3014979.

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High Grade Epithelial Ovarian Cancers (HGEOCs) is a heterogeneous group of tumours. Late diagnosis and drug-resistant recurrences make HGEOCs the most lethal gynaecological malignancy. The central role played by Cyclin-Dependent Kinases (CDKs), in a plethora of cellular mechanisms, such as control of cell cycle progression, DNA repair, transcription, and apoptosis, make them promising targets to overcome drug-resistance in HGEOCs. In this thesis we have focus on the possible role of CDK17 in the response to platinum (PT) starting from an unbiased loss of function shRNA screening, suggesting t

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33

Zribi, Aymen. "Fluxmètre thermique : conception, modélisation, réalisation et caractérisation. Mesures de températures et de densités de flux thermiques." Thesis, Besançon, 2016. http://www.theses.fr/2016BESA2085/document.

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En vue d'applications futures dans le domaine de la récupération d'énergie à basse température à partir de microsystèmes, la connaissance des transferts thermiques aux parois est d'une grande importance. Ces mesures sont réalisées à l'aide de capteurs spécifiques qui permettent de connaître le flux thermique total échangé entre la paroi sur laquelle ils sont installés et le milieu environnant. Cette étude se situe dans le cadre du développement de fluxmètres thermiques a gradient répondant aux contraintes liées aux machines thermiques de type micro-moteur Stirling. Six types de fluxmètres ther

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34

Sorensen, Daniel David. "Dissimilar Metal Joining in the Medical Device Industry." The Ohio State University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=osu1494157928729494.

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35

El, Bakali Abdelmagid. "Contribution à l’étude des échanges thermiques aux interfaces pour les procédés de formage à chaud : développement de moyens de mesure de l’émissivité et de la résistance thermique de contact (RTC) à haute température A fast and versatile method for spectral emissivity measurement at high temperatures." Thesis, Ecole nationale des Mines d'Albi-Carmaux, 2020. http://www.theses.fr/2020EMAC0004.

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Les travaux présentés ici concernent les échanges de chaleur entre une tôle métallique et un moule en béton réfractaire ou en acier inoxydable sont abordés pour des températures comprises entre 600 et 1000°C, voire plus. Ces échanges sont décomposés en deux étapes : une phase d’approche sans contact dite radiative qui nécessite la détermination des propriétés radiatives des solides en présence puis une phase avec contact : détermination d’une Résistance Thermique de Contact (ou « RTC ») à haute température. Pour décrire ces deux étapes, deux nouveaux moyens expérimentaux ont été étudiés et dév

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Pylväs-Eerola, M. (Marjo). "Oxidative stress in the pathogenesis and prognosis of ovarian cancer." Doctoral thesis, Oulun yliopisto, 2015. http://urn.fi/urn:isbn:9789526209982.

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Abstract Ovarian cancer is the fifth leading cause of cancer-associated death in women in Finland. Although ovarian cancer is relatively common, the precise mechanism of its development is still unknown. Additionally, it appears that the modes of pathogenesis differ depending on histotype. Although the initial response to platinum-based chemotherapy is usually good, the majority of ovarian cancer patients relapse and develop platinum resistance. This is a major problem in the treatment of ovarian cancer. Reactive oxygen species (ROS) are metabolites of oxygen. They are continuously formed in n

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Goddard, Phylis Maud. "Clinically predictive models for platinum drug development." Thesis, Institute of Cancer Research (University Of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.287475.

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Hullo, Marie. "Place des nanoparticules pour lutter contre la radio-résistance du cancer du sein : impact de l’hétérogénéité tumorale Gold Nanoparticle Uptake in Tumor Cells: Quantification and Size Distribution by sp-ICPMS . Radiation Enhancer Effect of Platinum Nanoparticles: Experimental in Vitrolimits Andrelevant Physical Chemical Simulation." Thesis, université Paris-Saclay, 2021. http://www.theses.fr/2021UPASL004.

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L’utilisation de nanoparticules de haut numéro atomique pour potentialiser les effets de la radiothérapie fait l’objet de nombreux travaux de recherches. Historiquement, l’intérêt porté à ces nanoparticules repose sur un principe d’action physique : en densifiant la matière, les nanoparticules localisées dans une tumeur augmentent localement la probabilité d’interaction des rayonnements ionisants avec celle-ci. L’augmentation de la dose délivrée localement serait alors associée à un stress oxydatif et à une augmentation des lésions de l’ADN. Ainsi la radio-sensibilisation liée aux nanoparticul

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Owen, S. A. "Corrosion resistance of electroless nickel deposits from aged and synthetic solutions." Thesis, University of Nottingham, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.311914.

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Solayman, Yahya Farahat Solayman. "Combination of platinums and phytochemicals aimed to overcome drug resistance in cancer." Thesis, University of Sydney, 2020. https://hdl.handle.net/2123/23636.

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Combined chemotherapy has drawn much attention for overcoming drug resistance and improving outcomes during the treatment of advanced stages of cancer. In the present study, cisplatin, oxaliplatin, LH5, gemcitabine, camptothecin and cucurbitacin B have been combined in a binary mode using three different sequences; i.e. bolus, 0/4 h and 4/0 h, in the ovarian and colorectal cancer models. Among the tested combinations of drugs, the combination of cisplatin with camptothecin and gemcitabine at all concentrations and for all sequences of addition, proved to be beneficial in overcoming cisplatin r

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Perumal, Meg. "Positron emission tomography imaging of platinum resistant ovarian cancer and drug modulation." Thesis, Imperial College London, 2012. http://hdl.handle.net/10044/1/10532.

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Epithelial ovarian cancer is the commonest cause of death from gynaecological malignancy. Platinum based chemotherapy remains the cornerstone of first-line therapy for ovarian cancer, however relapse is common and acquired resistance is frequently observed on subsequent lines of platinum based treatment. Because activation of the PI3K/AKT pathway has been shown to play a role in acquired platinum resistance phenotype of ovarian cancer, combination of platinum with AKT pathway inhibitors holds promise for resensitising tumours to platinum. The aims of this thesis were i) to evaluate the effect

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Clyne, Melanie Jane. "An investigation into the cis-platin resistance exhibited by MMR-defective S. Cerevisiae cells." Thesis, University of Sussex, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.499570.

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The primary function of the mismatch repair (MMR) pathway is to protect cells against the mutagenic and cytotoxic effects of mismatches incorporated by polymerases during replication. Accordingly, mutations in the MMR genes are commonly identified in patients with hereditary non-polyposis colon cancer (HNPCC) and somatic colorectal cancers. MMR function is of particular importance in cells exposed to DNA-damaging agents, as aberrant processing of damaged bases and erroneous bypass of bulky lesions increase the tendency for mismatch incorporation. The precise role of the MMR proteins in the pro

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43

Sathya, Santhana. "Fabrication of a thin film resistance heater." Ohio : Ohio University, 1999. http://www.ohiolink.edu/etd/view.cgi?ohiou1175624104.

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44

Schotter, Daniel Keith 1955. "The effects of heat treatment on microindentation hardness, abrasion and corrosion resistance of electroless nickel coatings." Thesis, The University of Arizona, 1988. http://hdl.handle.net/10150/276928.

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A study has been carried out to investigate the effects of heat treatment on microindentation hardness, abrasion and corrosion resistance of Electroless Nickel coatings. In particular, a proprietary coating system, NIKLAD 794 has been investigated. Samples of 4130 steel have been plated according to manufacturer's specifications. The plated samples have then been subjected to an array of heat treatment temperatures and times. Post heat treatment tests have been conducted including Taber Abrasion testing, salt fog chamber testing, and Knoop microindentation hardness testing. Results of the indi

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Daugherty, Ryan E. "Electrochemical Deposition of Nickel Nanocomposites in Acidic Solution for Increased Corrosion Resistance." Thesis, University of North Texas, 2017. https://digital.library.unt.edu/ark:/67531/metadc1011756/.

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The optimal conditions for deposition of nickel coating and Ni-layered double hydroxide metal matrix composite coatings onto stainless steel discs in a modified all-sulfate solutions have been examined. Nickel films provide good general corrosion resistance and mechanical properties as a protective layer on many metallic substrates. In recent years, there has been interest in incorporation nano-dimensional ceramic materials, such as montemorillonite, into the metal matrices to improve upon the corrosion and mechanical properties. Layered double hydroxides have been used as corrosion enhancer

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Vignat, Véronique. "Interet de l'association cis-platinium / radiotherapie dans le traitement palliatif de cancers chimio et radio resistants : a propos de six observations." Lyon 1, 1988. http://www.theses.fr/1988LYO1M255.

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Badenhorst, Hendrik Louis. "The environmental monitoring and quantification of M. tuberculosis occupational exposure risk in various occupational settings in a platinum mine / H.L. Badenhorst." Thesis, North-West University, 2010. http://hdl.handle.net/10394/4653.

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Tuberculosis is a disease that has a detrimental effect on the economic growth of South Africa. The country’s TB mortality rate is amongst the highest in the world, and the worst affected industry is mining. Effective environmental controls of tuberculosis in mining areas remain a challenge, mainly because there is a lack of quantitative data to guide the implementation of these controls. No occupational exposure limits exist for bio–aerosols, particularly Mycobacterium tuberculosis. This makes it difficult to distinguish between high– and low risk areas. It is believed that a single inhaled M

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Ganeshan, Dharshini. "Cell selection, characterization and regeneration of chlorsulfuron-resistant variants in asparagus." Lincoln University, 1999. http://hdl.handle.net/10182/1871.

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This thesis reports the cell culture establishment and a somatic cell selection system optimized for the isolation of chlorsulfuron-resistant variants in asparagus (Asparagus officinalis L.). The development of this cell selection system benefited the isolation of chlorsulfuron-resistant variants from an elite asparagus genotype. A cell culture system, suitable for somatic cell selection, was established for asparagus genotype CRD 168. Friable callus was initiated from etiolated shoots in darkness and used to produce a high density of single cells in suspension. Cell density was estimated base

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Paniagua, Edson Romário Monteiro. "Fronteiras, violência e criminalidade na Região Platina: o caso do município de Alegrete (1852-1864)." Universidade do Vale do Rio do Sinos, 2003. http://www.repositorio.jesuita.org.br/handle/UNISINOS/1843.

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Made available in DSpace on 2015-03-03T19:27:57Z (GMT). No. of bitstreams: 0 Previous issue date: 7<br>Nenhuma<br>Este trabalho analisa a violência e a criminalidade que se fizeram presentes na fronteira sul do Brasil, situada à oeste do estado do Rio Grande do Sul, na qual o município de Alegrete ocupou uma função geoestratégica relevante. Nesse sentido trabalhamos com as seguintes hipóteses: a fronteira do Alegrete, durante o período focalizado (1852 a 1864), não esteve marcada apenas pela intensidade dos intercâmbios comerciais e pela paz na política externa. Ela serviu como resistênci

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Cason, Claudio. "Gold alloys: study of the microstructural, mechanical characteristics and final optimization of production parameters for the realization of full and cable pipe chains." Doctoral thesis, Università degli studi di Padova, 2017. http://hdl.handle.net/11577/3422416.

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The gold market is one of the major world markets and the Italian companies place the country as one of the major players in this sector. However, the production in these companies is mostly based on the use of artisan skills, without investing in research and studies about the production processes of these materials. In fact, often the process depends on a "craft" way of working, in which the technical and scientific knowledge are dictated more by experience than by a systematic scientific approach. The international bibliography regarding the world of machining of gold alloys is not as devel

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