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Journal articles on the topic 'Resistance to platinum'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Jamieson, Jim. "A platinum resistance thermometer." Electronics Education 1991, no. 2 (1991): 7–9. http://dx.doi.org/10.1049/ee.1991.0018.

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2

Mei, Jia Bing, Jing Quan Liu, Shui Dong Jiang, Bin Yang, and Chun Sheng Yang. "Platinum Resistance Microsensor for Cryogenic Temperature Measurement." Key Engineering Materials 562-565 (July 2013): 198–203. http://dx.doi.org/10.4028/www.scientific.net/kem.562-565.198.

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Platinum resistance temperature sensor is applied to the temperature range higher than 200K currently. Through studying the principle of platinum temperature sensor, the platinum resistance temperature microsensor can be used in the temperature region between 10K and 200K was studied. It employs symmetrical turn back structure, which effectively avoids the inductance caused by alternating current (AC). Fabrication process based on MEMS technology was illustrated. The platinum film was obtained by direct current (DC) magnetron sputtering deposition and the platinum resistance temperature micros

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3

Han, Gwan Hee, Hanbyoul Cho, Hee Yun, and Jae-Hoon Kim. "PACSIN3 is a novel biomarker for platinum resistance BRCA mutated platinum resistance epithelial ovarian cancer." Journal of Clinical Oncology 40, no. 16_suppl (2022): e17540-e17540. http://dx.doi.org/10.1200/jco.2022.40.16_suppl.e17540.

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e17540 Background: Mutations in breast cancer susceptibility gene type 1 and type 2 (BRCA1 and BRCA2) put women at a higher risk of developing epithelial ovarian cancer (EOC). In individual carrying BRCA1 mutation has about 39-49% of the probability developing EOC in a lifetime. With BRCA2 mutations, the probability of developing EOC is about 11- 18 %. EOC patients with BRCA mutations shows an advanced histological grade compared to patients with BRCA wile type and respond better to platinum therapy, showing better survival. Patients with BRCA mutation shows better response to the platinum the

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4

Han, Gwan Hee, Hanbyoul Cho, Hee Yun, and Jae-Hoon Kim. "PACSIN3 is a novel biomarker for platinum resistance BRCA mutated platinum resistance epithelial ovarian cancer." Journal of Clinical Oncology 40, no. 16_suppl (2022): e17540-e17540. http://dx.doi.org/10.1200/jco.2022.40.16_suppl.e17540.

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e17540 Background: Mutations in breast cancer susceptibility gene type 1 and type 2 (BRCA1 and BRCA2) put women at a higher risk of developing epithelial ovarian cancer (EOC). In individual carrying BRCA1 mutation has about 39-49% of the probability developing EOC in a lifetime. With BRCA2 mutations, the probability of developing EOC is about 11- 18 %. EOC patients with BRCA mutations shows an advanced histological grade compared to patients with BRCA wile type and respond better to platinum therapy, showing better survival. Patients with BRCA mutation shows better response to the platinum the

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5

Chen, Hai Xiu, Hui Qiang Tang, and Yuan Yuan Li. "Research on Methods of Improving Platinum Resistance Sensor’s Temperature Measurement Precision." Advanced Materials Research 645 (January 2013): 255–58. http://dx.doi.org/10.4028/www.scientific.net/amr.645.255.

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Platinum resistance sensor is widely used in meteorological observation. In order to ensure the quality of temperature observation data, a number of experiments in different humidity, different working current, and in a constant temperature water tank and dry oven and other environments are completed with platinum resistance sensors. The experimental results are analyzed to investigate the influence factors of platinum resistance temperature measurement accuracy. The experiments can provide basis for objective evaluation of platinum resistance temperature sensor’s performance index, and for pl

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6

Nurseta, Tatit, and Ayu Rizky Widowati. "Nutritional status, hemoglobin, and albumin levels in predicting platinum resistance in ovarian cancer at Dr. Saiful Anwar Hospital, Malang, Indonesia." Majalah Obstetri & Ginekologi 32, no. 3 (2024): 168–73. http://dx.doi.org/10.20473/mog.v32i32024.168-173.

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HIGHLIGHTS Nutrition status, hemoglobin, and albumin levels are not predictors for platinum resistance. Hemoglobin and albumin levels increased in both platinum-sensitive or platinum-resistant. ABSTRACT Objective: This study aimed to determine whether nutritional status, hemoglobin, and albumin levels could serve as reliable predictors for predicting platinum resistance in patients with ovarian cancer. Materials and Methods: Conducted as a cross-sectional analysis, this study included 80 ovarian cancer patients who had completed six cycles of platinum-based chemotherapy. Patients were divided

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7

Rose, P. G. "Gemcitabine reverses platinum resistance in platinum-resistant ovarian and peritoneal carcinoma." International Journal of Gynecologic Cancer 15, Suppl 1 (2005): 18–22. http://dx.doi.org/10.1136/ijgc-00009577-200505001-00004.

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Platinum compounds are the key components of chemotherapy for ovarian cancer. Preclinical models in an ovarian cancer cell line (A2780) have demonstrated synergistic activity when gemcitabine is added to cisplatin compared with either single agent alone. Furthermore, the combination leads to increased platinum-adduct retention as a result of decreased DNA repair compared with cisplatin alone. Inhibition of specific exonucleases, such as excision repair cross-complementation group 1 (ERCC1), is integral to the platinum–gemcitabine synergy. In platinum-sensitive recurrent ovarian cancer patients

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8

Zhang, Jian Jun. "Design of New Pattern Combined Temperature Sensor." Advanced Materials Research 433-440 (January 2012): 5521–27. http://dx.doi.org/10.4028/www.scientific.net/amr.433-440.5521.

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In this paper, we present an idea about a new pattern combined temperature sensor that makes use of two sensors, one is platinum resistance that have good linearity and stability, the other is semiconductor resistance that have high sensitivity and fast response .We use the output of platinum resistance as measurement and calibration standard, and the output of semiconductor resistance for increment measurement, thus we got a better temperature sensor with both the advantages of platinum resistance and semiconductor resistance.

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9

van Zyl, Belinda, Denise Tang, and Nikola A. Bowden. "Biomarkers of platinum resistance in ovarian cancer: what can we use to improve treatment." Endocrine-Related Cancer 25, no. 5 (2018): R303—R318. http://dx.doi.org/10.1530/erc-17-0336.

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Ovarian cancer has poor survival rates due to a combination of diagnosis at advanced disease stages and disease recurrence as a result of platinum chemotherapy resistance. High-grade serous ovarian cancer (HGSOC), the most common ovarian cancer subtype, is conventionally treated with surgery and paclitaxel/carboplatin combination chemotherapy. Initial response rates are 60–80%, but eventually the majority of patients become platinum-resistant with subsequent relapses. Extensive research on individual biomarkers of platinum resistance has revealed many potential targets for the development new

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10

Campling, Barbara G. "The problem of platinum resistance." Cancer Biology & Therapy 5, no. 9 (2006): 1236–37. http://dx.doi.org/10.4161/cbt.5.9.3368.

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11

Killock, David. "WEE1 inhibition after platinum resistance." Nature Reviews Clinical Oncology 18, no. 4 (2021): 194. http://dx.doi.org/10.1038/s41571-021-00482-4.

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12

Kelland, Lloyd R. "Preclinical Perspectives on Platinum Resistance." Drugs 59, Supplement 4 (2000): 1–8. http://dx.doi.org/10.2165/00003495-200059004-00001.

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13

Giaccone, Giuseppe. "Clinical Perspectives on Platinum Resistance." Drugs 59, Supplement 4 (2000): 9–17. http://dx.doi.org/10.2165/00003495-200059004-00002.

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14

Weiss, Peter. "Powdered Platinum Sheds All Resistance." Science News 155, no. 23 (1999): 357. http://dx.doi.org/10.2307/4011339.

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15

Ohmichi, Masahide, Jun Hayakawa, Keiichi Tasaka, Hirohisa Kurachi, and Yuji Murata. "Mechanisms of platinum drug resistance." Trends in Pharmacological Sciences 26, no. 3 (2005): 113–16. http://dx.doi.org/10.1016/j.tips.2005.01.002.

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16

Stordal, Britta, and Ross Davey. "Platinum resistance needs the mythbusters." Toxicology Letters 180, no. 3 (2008): 230. http://dx.doi.org/10.1016/j.toxlet.2008.07.003.

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17

Knina, S. L., A. A. Nechai, A. A. Semenov, V. A. Petrushina, and A. I. Pokhodun. "Certifying precision platinum resistance thermometers." Measurement Techniques 33, no. 6 (1990): 586–88. http://dx.doi.org/10.1007/bf00977924.

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18

Choi, Min-Koo, and Dae-Duk Kim. "Platinum transporters and drug resistance." Archives of Pharmacal Research 29, no. 12 (2006): 1067–73. http://dx.doi.org/10.1007/bf02969293.

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19

Городнова, Татьяна Васильевна, Анна Петровна Соколенко, Христина Богдановна Котив, et al. "Platinum Resistance after Neoadjuvant Chemotherapy." Voprosy onkologii 70, no. 1 (2024): 82–87. http://dx.doi.org/10.37469/0507-3758-2024-70-1-82-87.

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Введение. В BRCA1-ассоциированных карциномах яичника резистентность к платине может возникать уже в процессе неоадъювантной химиотерапии за счет селекции и репопуляции клеток с восстановленной или частичной сохранной функцией репарации ДНК. Применение бесплатиновой адъювантной химиотерапии (АХТ) у больных без потери гетерозиготности BRCA1 в остаточной опухоли (noLOH) может улучшить результаты комбинированного лечения больных распространенным раком яичника. Цель — в рамках проспективного рандомизированного исследования NCT04747717 проанализировать результаты использования бесплатиновой АХТ по с

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20

Sonego, Maura, Ilenia Pellarin, Alice Costa, et al. "USP1 links platinum resistance to cancer cell dissemination by regulating Snail stability." Science Advances 5, no. 5 (2019): eaav3235. http://dx.doi.org/10.1126/sciadv.aav3235.

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Resistance to platinum-based chemotherapy is a common event in patients with cancer, generally associated with tumor dissemination and metastasis. Whether platinum treatment per se activates molecular pathways linked to tumor spreading is not known. Here, we report that the ubiquitin-specific protease 1 (USP1) mediates ovarian cancer cell resistance to platinum, by regulating the stability of Snail, which, in turn, promotes tumor dissemination. At the molecular level, we observed that upon platinum treatment, USP1 is phosphorylated by ATM and ATR and binds to Snail. Then, USP1 de-ubiquitinates

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21

Zuo, Xiao Qiong, Jian Ping Jia, and Juan Lei. "A Temperature Measurement Method Based on RC Discharge Circuit Using Platinum Resistance." Advanced Materials Research 1037 (October 2014): 143–46. http://dx.doi.org/10.4028/www.scientific.net/amr.1037.143.

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This paper proposes a temperature measuring method of low cost and stable precision based on platinum resistance. RC discharge circuit is composed of platinum resistor and fixed capacitor,the discharge time of fixed capacitance in the circuit is used for calculating the platinum resistance temperature resistance. The experimental results show that this is a simple and low cost method .

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22

Havasi, Andrei, Simona Sorana Cainap, Ana Teodora Havasi, and Calin Cainap. "Ovarian Cancer—Insights into Platinum Resistance and Overcoming It." Medicina 59, no. 3 (2023): 544. http://dx.doi.org/10.3390/medicina59030544.

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Ovarian cancer is the most lethal gynecologic malignancy. Platinum-based chemotherapy is the backbone of treatment for ovarian cancer, and although the majority of patients initially have a platinum-sensitive disease, through multiple recurrences, they will acquire resistance. Platinum-resistant recurrent ovarian cancer has a poor prognosis and few treatment options with limited efficacy. Resistance to platinum compounds is a complex process involving multiple mechanisms pertaining not only to the tumoral cell but also to the tumoral microenvironment. In this review, we discuss the molecular m

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23

Arias-Diaz, Andrea Estrella, Miriam Ferreiro-Pantin, Jorge Barbazan, et al. "Ascites-Derived Organoids to Depict Platinum Resistance in Gynaecological Serous Carcinomas." International Journal of Molecular Sciences 24, no. 17 (2023): 13208. http://dx.doi.org/10.3390/ijms241713208.

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Gynaecological serous carcinomas (GSCs) constitute a distinctive entity among female tumours characterised by a very poor prognosis. In addition to late-stage diagnosis and a high rate of recurrent disease associated with massive peritoneal carcinomatosis, the systematic acquisition of resistance to first-line chemotherapy based on platinum determines the unfavourable outcome of GSC patients. To explore the molecular mechanisms associated with platinum resistance, we generated patient-derived organoids (PDOs) from liquid biopsies of GSC patients. PDOs are emerging as a relevant preclinical mod

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24

Trifanescu, Oana, Laurentia Minea Gales, Maria Iuliana Gruia, Bianca Andreea Gusoiu, Florina Torliceanu, and Anghel Rodica Maricela. "New biomarkers to predict platinum resistance in ovarian cancer patients." Journal of Clinical Oncology 37, no. 15_suppl (2019): e17085-e17085. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.e17085.

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e17085 Background: Epithelial ovarian cancer is the second most common gynecologic malignancy and is characterized by the highest mortality of all gynecological cancers. Despite of initial response, platinum resistance develops and contributes to the poor outcome of advanced stage ovarian cancer patients. The aim of the study was to identify biomarkers helpful in predicting treatment response to platinum salts. Methods: Forty eight patients with advanced ovarian (stage II, III and IV) cancer were prospectively enrolled between 2014 and 2017. All patients underwent surgery followed by platinum-

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25

Elyashiv, Osnat, Natalie Aleohin, Zohar Migdan, et al. "The Poor Prognosis of Acquired Secondary Platinum Resistance in Ovarian Cancer Patients." Cancers 16, no. 3 (2024): 641. http://dx.doi.org/10.3390/cancers16030641.

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Objective: The goal of this study was to evaluate response to treatment and survival in epithelial ovarian cancer patients with acquired secondary platinum resistance (SPR) compared to patients with primary platinum resistance (PPR). Methods: Patients were categorized as PPR (patients with disease recurrence occurring during or <6 months after completing first-line platinum-based chemotherapy) and SPR (patients with previously platinum-sensitive disease that developed platinum resistance on subsequent treatments). Clinico-pathological variables and treatment outcomes were compared. Results:

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26

Merker, Jürgen, David F. Lupton, and F. Schölz. "Precious Metals in High Temperature Applications - The Cause of Damage and its Avoidance." Materials Science Forum 706-709 (January 2012): 2434–39. http://dx.doi.org/10.4028/www.scientific.net/msf.706-709.2434.

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The broad application of platinum and platinum alloys results from their excellent high temperature mechanical properties as well as their near-perfect oxidation resistance and their outstanding resistance to corrosive attack by metal oxide melts such as fluxing agents. However, a few basic rules must be adhered to if platinum devices are to give satisfactory service. Platinum is susceptible to “platinum poisons” and other impurities. These “poisons”, the reasons for their corrosive effects, and techniques for minimizing or eliminating their influence are outlined.

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27

Yang, Qiang, Ruogu Qi, Jing Cai, et al. "Biodegradable polymer–platinum drug conjugates to overcome platinum drug resistance." RSC Advances 5, no. 101 (2015): 83343–49. http://dx.doi.org/10.1039/c5ra11297d.

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28

Sun, Yan Qiu. "The Design of the Marine Temperature Sensor Verifier Based on Single-Chip Microcomputer." Advanced Materials Research 546-547 (July 2012): 1511–15. http://dx.doi.org/10.4028/www.scientific.net/amr.546-547.1511.

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Using conventional passive resistance box to verify Pt100 platinum thermal resistance, Listing Temperature and Pt100 platinum resistance must be remember by users. It is difficult to manipulate. Temperature verifier based on single-chip microcomputer is small, high accuracy, multi-output, temperature and resistance comparison, which can improve production efficiency considerably.

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29

Wu, Baoyuan, and Ge Liu. "Platinum: Platinum-Rhodium Thermocouple Wire." Platinum Metals Review 41, no. 2 (1997): 81–85. http://dx.doi.org/10.1595/003214097x4128185.

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A new type of platinum:platinum-rhodium thermocouple wire which incorporates traces of yttrium in the platinum limb has been developed and tested in some typical working environments. This thermocouple possesses good thermal stability and mechanical strength at high temperatures, and a long service life, compared with conventional platinum:platinum-rhodium thermocouples. The thermocouple meets the output requirements of the Type S standard for thermocouples — those made of Pt:Pt-10%Rh — whose manufacturing tolerances are prescribed by the International Electrotechnical Commission (I.E.C.)(l).

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30

Huang, Dongqing, Sara R. Savage, Anna P. Calinawan, et al. "A highly annotated database of genes associated with platinum resistance in cancer." Oncogene 40, no. 46 (2021): 6395–405. http://dx.doi.org/10.1038/s41388-021-02055-2.

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AbstractPlatinum-based chemotherapy, including cisplatin, carboplatin, and oxaliplatin, is prescribed to 10-20% of all cancer patients. Unfortunately, platinum resistance develops in a significant number of patients and is a determinant of clinical outcome. Extensive research has been conducted to understand and overcome platinum resistance, and mechanisms of resistance can be categorized into several broad biological processes, including (1) regulation of drug entry, exit, accumulation, sequestration, and detoxification, (2) enhanced repair and tolerance of platinum-induced DNA damage, (3) al

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31

Yu, Ping, Chunliang Shang, Zhongyu Liu, et al. "High Co-Expression of GPAT4 and SLC7A11 as a Predictor of Platinum Resistance and Poor Prognosis in Patients with Epithelial Ovarian Cancer." Biomedicines 13, no. 7 (2025): 1664. https://doi.org/10.3390/biomedicines13071664.

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Background/Objectives: This study aimed to determine whether the expression levels of GPAT4 and SLC7A11 are associated with survival outcomes and platinum resistance in epithelial ovarian cancer (EOC) patients. Methods: We analyzed the medical records of EOC patients. EOC samples obtained during surgery were stained for GPAT4 and SLC7A11. Cox regression and Kaplan—Meier analyses were performed to assess the impact of GPAT4 and SLC7A11 expression on overall survival (OS). Results: We found that GPAT4 and SLC7A11 expression levels were greater in platinum-resistant ovarian cancer tissues than in

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32

Xu, Manman, Xi Huang, Cuimiao Zheng, et al. "Platinum-Resistant Ovarian Cancer Is Vulnerable to the cJUN-XRCC4 Pathway Inhibition." Cancers 14, no. 24 (2022): 6068. http://dx.doi.org/10.3390/cancers14246068.

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DNA double-strand breaks (DSBs) caused by platinum drugs are dangerous lesions that kill cancer cells in chemotherapy. Repair of DSB by homologous recombination (HR) and nonhomologous end joining (NHEJ) is frequently associated with platinum resistance in ovarian cancer. While the role of the HR pathway and HR-targeting strategy in platinum resistance is well studied, dissecting and targeting NHEJ machinery to overcome platinum resistance in ovarian cancer remain largely unexplored. Here, through an NHEJ pathway-focused gene RNAi screen, we found that the knockdown of XRCC4 significantly sensi

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33

Ma, Lu, Hua Liu, Yichun Ju, et al. "Synthesis and Antitumor Activity of a GSH Inert Bisphosphonate Platinum (II) Complex." Journal of Chemistry 2022 (October 7, 2022): 1–11. http://dx.doi.org/10.1155/2022/3137142.

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Osteosarcoma is a highly aggressive neoplasm. Traditional platinum chemotherapeutic agents for osteosarcoma inevitably have acquired drug resistance and serious side effects, which have limited their utility. To slow down the reaction of platinum drugs with glutathione (GSH) is a strategy to overcome the resistance of platinum chemotherapeutic agents. Herein, the unique design of a GSH inert bisphosphonate platinum complex cis-{di(amino)platinum[tetraethyl 2,2-bis(2-pyridinylmethyl)methylidene-1,1-bisphosphonate]} (DBPP) is reported. MTT assay demonstrates that DBPP showed moderate inhibition

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34

Matsuo, Koji, Yvonne G. Lin, Lynda D. Roman, and Anil K. Sood. "Overcoming platinum resistance in ovarian carcinoma." Expert Opinion on Investigational Drugs 19, no. 11 (2010): 1339–54. http://dx.doi.org/10.1517/13543784.2010.515585.

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35

Golub, V. V., Yu V. Zhilin, and S. A. Rylov. "A Platinum Thin-Film Resistance Thermometer." Instruments and Experimental Techniques 61, no. 3 (2018): 453–58. http://dx.doi.org/10.1134/s0020441218030120.

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36

Los, Gerrit, and Franco M. Muggia. "Platinum Resistance: Experimental and Clinical Status." Hematology/Oncology Clinics of North America 8, no. 2 (1994): 411–29. http://dx.doi.org/10.1016/s0889-8588(18)30179-5.

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37

Shahzad, Mian M. K., Gabriel Lopez-Berestein, and Anil K. Sood. "Novel strategies for reversing platinum resistance." Drug Resistance Updates 12, no. 6 (2009): 148–52. http://dx.doi.org/10.1016/j.drup.2009.09.001.

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38

Yiu, E. Y. L., D. T. S. Fang, F. C. S. Chu, and T. W. Chow. "Corrosion resistance of iron–platinum magnets." Journal of Dentistry 32, no. 6 (2004): 423–29. http://dx.doi.org/10.1016/j.jdent.2004.02.007.

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39

Rose, P. G. "Gemcitabine reverses platinum resistance in platinum-resistant ovarian and peritoneal carcinoma." International Journal of Gynecological Cancer 15, s1 (2005): 18–22. http://dx.doi.org/10.1111/j.1525-1438.2005.15357.x.

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40

Tyulyandina, Alexandra, Maxim Filipenko, Alexey Rumyantsev, et al. "Impact of BRCA mutation status and time to platinum resistance on patients with advanced ovarian cancer." Journal of Clinical Oncology 37, no. 15_suppl (2019): 5561. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.5561.

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5561 Background: The influence of germline BRCA1/2 mutations (gBRCAmt) on ovarian cancer patients (pts) long-term survival remains controversial. Methods: 228 pts with serous and endometrial ovarian cancer stage Ic-IV were enrolled in the retrospective study. Next-generation sequencing testing of BRCA1/2 in blood was employed. Progression-free survival (PFS), overall survival (OS) and time to platinum resistance (TPR) were analyzed. TPR was defined as time from first line chemotherapy to registration of platinum resistance relapse. Results: The rate of pathogenic gBRCAmt was defined in 29.4% (

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41

Du, Li Dong, Li Xiao, Zhan Zhao, et al. "Temperature Characteristic of Platinum Piezoresistive Pressure Sensor." Key Engineering Materials 483 (June 2011): 180–84. http://dx.doi.org/10.4028/www.scientific.net/kem.483.180.

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Temperature characteristic of platinum piezoresistive atmosphere pressure sensor is studied in this paper, in which platinum is used as the sensing material and SU-8 is used as adhesive bonding layer. Normally, temperature variation will bring on resistance change of sensing platinum resistor with a linear relationship. Simultaneously, the thermal expansion mismatching in different material will also change the resistance. They both affect the temperature characteristic of sensor. Based on elasticity theory, the relationship between resistance change and thermal expansion mismatching is analyz

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Koren Carmi, Yifat, Hatem Mahmoud, Hazem Khamaisi, Rina Adawi, Jacob Gopas, and Jamal Mahajna. "Flavonoids Restore Platinum Drug Sensitivity to Ovarian Carcinoma Cells in a Phospho-ERK1/2-Dependent Fashion." International Journal of Molecular Sciences 21, no. 18 (2020): 6533. http://dx.doi.org/10.3390/ijms21186533.

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Ovarian cancer (OC) is the second most common type of gynecological malignancy; it has poor survival rates and is frequently (>75%) diagnosed at an advanced stage. Platinum-based chemotherapy, with, e.g., carboplatin, is the standard of care for OC, but toxicity and acquired resistance to therapy have proven challenging. Despite advances in OC diagnosis and treatment, approximately 85% of patients will experience relapse, mainly due to chemoresistance. The latter is attributed to alterations in the cancer cells and is also mediated by tumor microenvironment (TME). Recently, we reported the

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43

MacAulay Vacheresse, Genevieve, Elham Sabri, Sheryl Domingo, and Tien Le. "Response to subsequent platinum-based chemotherapy post PARP inhibitor in recurrent epithelial ovarian cancer." Journal of Clinical Oncology 41, no. 16_suppl (2023): 5578. http://dx.doi.org/10.1200/jco.2023.41.16_suppl.5578.

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5578 Background: Maintenance therapy with PARP inhibitors (PARPi) can increase progression free survival (PFS) for recurrent or metastatic platinum-sensitive epithelial ovarian cancer (EOC). Little is known about disease trajectory following treatment with these agents, though some evidence suggests a decreased response to subsequent platinum-based chemotherapy. This retrospective cohort study assessed real-world response rates to platinum-based chemotherapy for recurrent high grade EOC following treatment with a PARPi. Methods: All patients prescribed a PARPi as maintenance therapy for recurr

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44

Overchuk, Marta, Brittany P. Rickard, Justin Tulino, Frances S. Ligler, and Imran Rizvi. "Abstract B111: Mechanism-informed photochemical strategies to overcome fluid shear stress-induced platinum resistance in ovarian cancer." Cancer Research 84, no. 5_Supplement_2 (2024): B111. http://dx.doi.org/10.1158/1538-7445.ovarian23-b111.

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Abstract Background: Over 75% of patients with disseminated ovarian cancer develop resistance to platinum-based chemotherapies (carboplatin or cisplatin). Patients with a high volume of malignant ascites or excessive fluid buildup in the peritoneum are more likely to present with primary platinum-resistant disease. It is hypothesized that the physical forces generated by ascites may contribute to the dissemination and progression of ovarian cancer. Our research group has shown that fluid shear stress (FSS) induces carboplatin resistance and a motile and aggressive phenotype in monolayer cultur

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45

Zhang, Hongqin, Tianqing Yan, Ailing Zhong, Lin Guo, and Renquan Lu. "COPS5 Conferred the Platinum Resistance in Epithelial Ovarian Cancer." Current Issues in Molecular Biology 44, no. 9 (2022): 3948–58. http://dx.doi.org/10.3390/cimb44090271.

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Development of platinum resistance is one of the major causes of epithelial ovarian cancer (EOC) treatment failure. COP9 signalosome subunit 5 (COPS5) was found to take part in the progression of EOC in our previous study. Herein, we aim to uncover the potential utility of COPS5 in EOC chemoresistance. COPS5 levels were analyzed to define clinic pathologic correlates using a matched tissue microarray and online datasets. The effect of COPS5 inhibition by the lentivirus-mediated short hairpin RNA on cell viability, proliferation and migration was accessed in vitro and in vivo. Results showed th

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Dai, Ziwen, and Zhigang Wang. "Photoactivatable Platinum-Based Anticancer Drugs: Mode of Photoactivation and Mechanism of Action." Molecules 25, no. 21 (2020): 5167. http://dx.doi.org/10.3390/molecules25215167.

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Platinum-based anticancer drugs are a class of widely used agents in clinical cancer treatment. However, their efficacy was greatly limited by their severe side effects and the arising drug resistance. The selective activation of inert platinum-based drugs in the tumor site by light irradiation is able to reduce side effects, and the novel mechanism of action of photoactivatable platinum drugs might also conquer the resistance. In this review, the recent advances in the design of photoactivatable platinum-based drugs were summarized. The complexes are classified according to their mode of acti

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Fischer, Bernd, Andreas Behrends, Dietmar Freund, David F. Lupton, and Jiirgen Merker. "High Temperature Mechanical Properties of the Platinum Group Metals." Platinum Metals Review 43, no. 1 (1999): 18–28. http://dx.doi.org/10.1595/003214099x4311828.

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There is a constantly increasing need for metallic materials with melting points over 1700°C for use at very high temperatures. In contrast to the refractory metals: tantalum, niobium, tungsten, molybdenum and rhenium, which also have very high melting points, the metals of the platinum group, particularly platinum, rhodium and iridium, are characterised by outstanding chemical stability, oxidation resistance and resistance to many molten oxides. The platinum group metals are therefore ideal materials for using at high temperatures while undergoing simultaneous chemical attack and mechanical l

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Wang, Wenwen, Wenwen Zhang, and Yuanjing Hu. "Identification of keygenes, miRNAs and miRNA-mRNA regulatory pathways for chemotherapy resistance in ovarian cancer." PeerJ 9 (November 8, 2021): e12353. http://dx.doi.org/10.7717/peerj.12353.

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Background Chemotherapy resistance, especially platinum resistance, is the main cause of poor prognosis of ovarian cancer. It is of great urgency to find molecular markers and mechanism related to platinum resistance in ovarian cancer. Methods One mRNA dataset (GSE28739) and one miRNA dataset (GSE25202) were acquired from Gene Expression Omnibus (GEO) database. The GEO2R tool was used to screen out differentially expressed genes (DEGs) and differentially expressed miRNAs (DE-miRNAs) between platinum-resistant and platinum-sensitive ovarian cancer patients. Gene Ontology (GO) function and Kyoto

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Coffetti, Giulia, Martina Moraschi, Giorgio Facchetti, and Isabella Rimoldi. "The Challenging Treatment of Cisplatin-Resistant Tumors: State of the Art and Future Perspectives." Molecules 28, no. 8 (2023): 3407. http://dx.doi.org/10.3390/molecules28083407.

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One of the main problems in chemotherapy using platinum drugs as anticancer agents is the resistance phenomenon. Synthesizing and evaluating valid alternative compounds is challenging. This review focuses on the last two years of progress in the studies of platinum (II)- and platinum (IV)-based anticancer complexes. In particular, the research studies reported herein focus on the capability of some platinum-based anticancer agents to bypass resistance to chemotherapy, which is typical of well-known drugs such as cisplatin. Regarding platinum (II) complexes, this review deals with complexes in

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Du, Qing Fu. "Temperature Measurement with High Accuracy." Advanced Materials Research 301-303 (July 2011): 1333–38. http://dx.doi.org/10.4028/www.scientific.net/amr.301-303.1333.

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Calibration of general temperature sensor, platinum resistor is done with measuring its zero resistance and dispersity of linear system and compensating. Accurate constant current source is used to provide platinum resistor sensor power and four-wire measuring method is designed for self-compensation of lead wire resistance. With amplifying the changing signal of platinum using amplifier of high precision and low temperature drift, and MCPU digital filtering, highly accurate temperature measurement result is got finally.

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