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Dissertations / Theses on the topic 'Resistance to viral infection'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Heath, Sarah E. "Evolutionary consequences of viral resistance in the marine picoeukaryote Ostreococcus tauri." Thesis, University of Edinburgh, 2018. http://hdl.handle.net/1842/31082.

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In marine environments, eukaryotic marine microalgae coexist with the viruses that infect them. Marine microalgae are the main primary producers in the oceans and are at the base of the marine food web. Viruses play important roles in top-down control of algae populations, cycling of organic matter, and as evolutionary drivers of their hosts. Algae must adapt in response to the strong selection pressure that viruses impose for resistance to infection. In addition to biotic selection pressures such as viral infections, algae must also adapt to their abiotic environment. Global climate change is

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2

Moody, Adrian John. "Mapping genetic resistance to infectious bursal disease." Thesis, University of Reading, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.326754.

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3

Lowe, Alexander Paul. "The role of viral and bacterial infections in asthma exacerbations and corticosteroid resistance." Thesis, Cardiff University, 2013. http://orca.cf.ac.uk/47342/.

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Asthma is a chronic inflammatory disease of the airways characterised by early and late asthmatic responses (EAR & LAR) to allergen, airways hyperresponsiveness (AHR) to inhaled spasmogens, airway inflammation and airway oedema. Viral infections and lipopolysaccharide (LPS) from bacteria and environmental sources contribute to exacerbations of asthma and the development of insensitivity to corticosteroids. Complete insensitivity to oral corticosteroids is rare and most patients lie on a continuum of steroid responsiveness. This thesis aimed to examine the effect of viral infection and LPS in a

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4

Burgan, Sarah Catherine. "From Tolerance to Transmission: Linking Within-Individual to Community-Level Disease Processes." Scholar Commons, 2016. http://scholarcommons.usf.edu/etd/6193.

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Hosts have two main strategies for coping with infections: resistance and tolerance. Resistance is aimed at preventing or eliminating parasites, whereas the goal of tolerance is to maintain performance regardless of parasite burden. The balance between resistance and tolerance within a host may mediate host competence, or the propensity of a host to infect other hosts or vectors. Hosts with high tolerance and low resistance to an infection, for instance, may be highly competent and possess the greatest potential to act as superspreaders. These superspreading hosts will contribute disproportion

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5

Okleberry, Kevin M. "Metabolism of Selected Antiviral Agents in Cells Infected with Drug-Resistant and Wild-Type Strains of Murine Cytomegalovirus." DigitalCommons@USU, 1995. https://digitalcommons.usu.edu/etd/4657.

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Resistance of human viral pathogens to various antiviral drugs is a serious medical problem. Two modes of drug resistance in cytomegalovirus infections have been observed, the first being altered (decreased) drug metabolism by the infected cells, and the second reduced sensitivity of the viral deoxyribonucleic acid polymerase enzyme to the active form of the drug. Mice infected with the murine cytomegalovirus have been used extensively as an animal model for the human cytomegalovirus, and drug-resistant strains in this model have been identified. To better understand the mode of drug resistanc

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6

Lin, Kuan-Hung. "Viral Proteases as Drug Targets and the Mechanisms of Drug Resistance: A Dissertation." eScholarship@UMMS, 2016. https://escholarship.umassmed.edu/gsbs_diss/841.

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Viral proteases have been shown to be effective targets of anti-viral therapies for human immunodeficiency virus (HIV) and hepatitis C virus (HCV). However, under the pressure of therapy including protease inhibitors, the virus evolves to select drug resistance mutations both in the protease and substrates. In my thesis study, I aimed to understand the mechanisms of how this protease−substrate co-evolution contributes to drug resistance. Currently, there are no approved drugs against dengue virus (DENV); I investigated substrate recognition by DENV protease and designed cyclic peptides as inhi

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7

Lin, Kuan-Hung. "Viral Proteases as Drug Targets and the Mechanisms of Drug Resistance: A Dissertation." eScholarship@UMMS, 2009. http://escholarship.umassmed.edu/gsbs_diss/841.

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Viral proteases have been shown to be effective targets of anti-viral therapies for human immunodeficiency virus (HIV) and hepatitis C virus (HCV). However, under the pressure of therapy including protease inhibitors, the virus evolves to select drug resistance mutations both in the protease and substrates. In my thesis study, I aimed to understand the mechanisms of how this protease−substrate co-evolution contributes to drug resistance. Currently, there are no approved drugs against dengue virus (DENV); I investigated substrate recognition by DENV protease and designed cyclic peptides as inhi

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8

Ozen, Aysegul. "Structure and Dynamics of Viral Substrate Recognition and Drug Resistance: A Dissertation." eScholarship@UMMS, 2013. https://escholarship.umassmed.edu/gsbs_diss/677.

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Drug resistance is a major problem in quickly evolving diseases, including the human immunodeficiency (HIV) and hepatitis C viral (HCV) infections. The viral proteases (HIV protease and HCV NS3/4A protease) are primary drug targets. At the molecular level, drug resistance reflects a subtle change in the balance of molecular recognition; the drug resistant protease variants are no longer effectively inhibited by the competitive drug molecules but can process the natural substrates with enough efficiency for viral survival. Therefore, the inhibitors that better mimic the natural substrate bindin

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9

Ozen, Aysegul. "Structure and Dynamics of Viral Substrate Recognition and Drug Resistance: A Dissertation." eScholarship@UMMS, 2005. http://escholarship.umassmed.edu/gsbs_diss/677.

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Drug resistance is a major problem in quickly evolving diseases, including the human immunodeficiency (HIV) and hepatitis C viral (HCV) infections. The viral proteases (HIV protease and HCV NS3/4A protease) are primary drug targets. At the molecular level, drug resistance reflects a subtle change in the balance of molecular recognition; the drug resistant protease variants are no longer effectively inhibited by the competitive drug molecules but can process the natural substrates with enough efficiency for viral survival. Therefore, the inhibitors that better mimic the natural substrate bindin

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10

Svedhem, Johansson Veronica. "Kinetics of HIV-1 drug resistance mutations in vivo /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-671-9/.

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11

Go, Yun Young. "MOLECULAR AND GENOMIC APPROACHES TO UNDERSTANDING HOST-VIRUS INTERACTIONS IN SHAPING THE OUTCOME OF EQUINE ARTERITIS VIRUS INFECTION." UKnowledge, 2011. http://uknowledge.uky.edu/gradschool_diss/840.

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Equine arteritis virus (EAV) is the causal agent of equine viral arteritis, a disease of equids. During natural outbreaks of the disease, EAV can cause abortion in pregnant mares and persistent infection in stallions. Understanding how host cellular proteins interact with viral RNA and viral proteins, as well as their role in viral infection, will enable better characterization of the pathogenesis of EAV and establishment of persistent infection in stallions. Accordingly, we hypothesized that both viral factors and host genetically related factors could influence the outcome of EAV infection i

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12

Campos, Juliana Roberta. "EFFECTS ON SEMEN QUALITY AND ON ESTABLISHMENT OF PERSISTENT EQUINE ARTERITIS VIRUS (EAV) INFECTION IN STALLIONS FOLLOWING EXPERIMENTAL CHALLENGE WITH THE KENTUCKY 84 (KY84) STRAIN." UKnowledge, 2012. http://uknowledge.uky.edu/gluck_etds/6.

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Equine arteritis virus (EAV) is the causal agent of equine viral arteritis (EVA), a disease of equids. Following EAV infection, up to 70% of stallions may become carriers and continuously shed the virus in their semen for varying time periods. The long-term carrier stallion has an important role in the transmission and maintenance of EAV in horse populations. Recently, it has been demonstrated a correlation between in vitro susceptibility of CD3+ T lymphocytes to EAV infection and establishment of long-term persistent infection among stallions following natural infections. In this study, we in

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13

Lindström, Anna. "Resistance to antiviral drugs in HIV and HBV /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-239-X/.

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14

Foy, Pierre-Emmanuel. "Conséquences des infections virales respiratoires sur le microenvironnement tumoral pulmonaire." Electronic Thesis or Diss., Sorbonne université, 2024. https://accesdistant.sorbonne-universite.fr/login?url=https://theses-intra.sorbonne-universite.fr/2024SORUS044.pdf.

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Le cancer bronchique, ou pulmonaire, est la première cause de décès dans le monde par cancer. Le traitement repose sur la chirurgie, quand la tumeur est résécable, et sur un traitement adjuvant associant généralement la chimiothérapie à la radiothérapie, l'immunothérapie ou les thérapies ciblées.Les patients atteints de cancer du poumon non à petites cellules (CBNPC) sont fréquemment exposés à des infections virales telles l'Influenza A (IAV) ou le SARS-CoV-2. Le microenvironnement tumoral (MET) est un écosystème complexe et hétérogène qui conditionne la croissance des cellules tumorales, la r

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15

Leriche-Guérin, Karine. "Résistance à l'AZT dans l'infection par le VIH-1 : influence sur les critères biologiques, virologiques et immunologiques." Lyon 1, 1998. http://www.theses.fr/1998LYO1T042.

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16

Cantrell, Ronald Alexander. "Diagnosing antiretroviral treatment failure in resource-limited settings." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2008. https://www.mhsl.uab.edu/dt/2008p/cantrell.pdf.

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17

Bandaranayake, Rajintha M. "Exploring Molecular Mechanisms of Drug Resistance in HIV-1 Protease through Biochemical and Biophysical Studies: A Dissertation." eScholarship@UMMS, 2010. https://escholarship.umassmed.edu/gsbs_diss/487.

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The human immunodeficiency virus type-1 (HIV-1) is the leading cause of acquired immunodeficiency syndrome (AIDS) in the world. As there is no cure currently available to treat HIV-1 infections or AIDS, the major focus of drug development efforts has been to target viral replication in an effort to slow down the progression of the infection to AIDS. The aspartyl protease of HIV-1 is an important component in the viral replication cycle and thus, has been an important anti-HIV-1 drug target. Currently there are nine protease inhibitors (PIs) that are being used successfully as a part of highly

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18

Palich, Romain. "Impact de la résistance virale acquise dans le passé sur les stratégies antirétrovirales actuelles." Electronic Thesis or Diss., Sorbonne université, 2021. http://www.theses.fr/2021SORUS493.

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Dans le champ de la prise en charge du VIH, aujourd’hui en France, trois situations continuent d’occuper la réflexion : 1) les virémies de bas niveau persistantes, malgré un traitement ARV prolongé et une observance rapportée optimale, 2) la persistance ou la clairance dans le réservoir viral de mutations de résistance sélectionnées dans l’histoire virologique, et 3) l’allègement thérapeutique optimal chez les patients virologiquement contrôlés. Dans un premier travail, nous avons montré que 72% des patients présentant une virémie de bas niveau persistante, déclarant une bonne observance, avai

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19

Jode, Mathieu de. "Two examples of exploiting bacteriophages to defeat Pseudomonas aeruginosa : study of the viral protein Gp92 and in vivo evaluation of the efficacy of a bacteriophage cocktail to treat pneumonia in immunocompromised animals." Electronic Thesis or Diss., Sorbonne université, 2021. http://www.theses.fr/2021SORUS030.

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Nous avons étudié des phages infectant Pseudomonas aeruginosa pour développer des stratégies antibactériennes. Nous avons d’abord étudié les mécanismes des stratégies virales détournant les fonctions bactériennes, et découvert que l’expression du gène phagique gp92 altère la morphologie bactérienne, la motilité et le protéome cellulaire, sans affecter la croissance. Gp92 altère également la réponse au stress membranaire médiée par AlgU, via son interaction avec MucA. Cette perturbation pourrait aider le phage à contrôler la lyse. Enfin, l'expression de gp92 augmente la sensibilité de P. aerugi

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20

Cartagena, Juan Carlos. "Contribution a l'etude de la sensibilite des insectes aux maladies infectieuses : influence de la fumure sur la sensibilite d'un insecte phytophage, spodoptera littoralis, boisduval (lepidoptera, noctuidae), a la polyedrose nucleaire." Paris 6, 1987. http://www.theses.fr/1987PA066152.

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On etudie la biologie du developpement et la sensibilite des chenilles de s. Littoralis a une polyedrose nucleaire. L'etude est realisee en fonction des fumures appliquees sans discontinuite chaque annee sur une culture de betteravess. Une carence azotee du regime alimentaire retarde le developpement des larves. Une deficience en phosphore provoque une diminution de la capacite reproductive des adultes. La sensibilite des chenilles a la virose est liee a la teneur de l'azote dans les feuilles et croit avec l'age des feuilles sur lesquelles elles s'alimentent

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21

Nikin-Beers, Ryan Patrick. "Immunoepidemiological Modeling of Dengue Viral Infection." Diss., Virginia Tech, 2018. http://hdl.handle.net/10919/82924.

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Dengue viral infection is a mosquito-borne disease with four distinct strains, where the interactions between these strains have implications on the severity of the disease outcomes. The two competing hypotheses for the increased severity during secondary infections are antibody dependent enhancement and original antigenic sin. Antibody dependent enhancement suggests that long-lived antibodies from primary infection remain during secondary infection but do not neutralize the virus. Original antigenic sin proposes that T cells specific to primary infection dominate cellular immune responses dur

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22

Nikin-Beers, Ryan Patrick. "Mathematical Modeling of Dengue Viral Infection." Thesis, Virginia Tech, 2014. http://hdl.handle.net/10919/48594.

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In recent years, dengue viral infection has become one of the most widely-spread mosquito-borne diseases in the world, with an estimated 50-100 million cases annually, resulting in 500,000 hospitalizations. Due to the nature of the immune response to each of the four serotypes of dengue virus, secondary infections of dengue put patients at higher risk for more severe infection as opposed to primary infections. The current hypothesis for this phenomenon is antibody-dependent enhancement, where strain-specific antibodies from the primary infection enhance infection by a heterologous serotype. To

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23

James, Katherine Louise. "Viral genetics of HIV-2 infection." Thesis, University of Oxford, 2015. https://ora.ox.ac.uk/objects/uuid:68ba022d-62e4-4cb1-8032-085ea5240b98.

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HIV-2 is a contemporary human retrovirus with the majority of infections localised to West Africa. Both HIV-1 and HIV-2 are able to cause AIDS; however, in contrast to HIV-1 infection, a common outcome following HIV-2 infection (&Tilde; 37&percnt; of patients in this study cohort) is long-term non-progression (LTNP), where patients remain aviraemic and asymptomatic in the absence of treatment, often for decades. HIV-1 and HIV-2 both arose following zoonotic transmission of SIVs from non-human primates at around the beginning of the 20<sup>th</sup> century and when patients develop AIDS caused

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24

Pruikkonen, H. (Hannele). "Viral infection induced respiratory distress in childhood." Doctoral thesis, Oulun yliopisto, 2015. http://urn.fi/urn:isbn:9789526207919.

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Abstract Dyspnoea associated with respiratory infection is a common symptom in infancy and early childhood. Inspiratory stridor is the main symptom in cases of croup and expiratory wheezing in cases of bronchiolitis, obstructive bronchitis and acute asthma exacerbations. Dyspnoea associated with respiratory infection is a common cause of emergency department visits and unplanned hospital admissions among infants and preschool children. The assessment of dyspnea associated with acute childhood respiratory infection is largely subjective, and evidence regarding the severity of acute dyspnoea is

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25

Howat, Tom James. "Spatial dynamics of in vitro viral infection." Thesis, University of Cambridge, 2007. https://www.repository.cam.ac.uk/handle/1810/252041.

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Despite the importance of the IFNs in viral infections, many questions about the dynamics of IFN production and activity remain unanswered. Addressing these questions forms the first half of this thesis. It begins with an introduction to innate immunity, and a review of existing research. Focus then falls upon a simple experimental system: the <i>in vitro</i> infection of cell monolayers by Herpes simplex virus and the resulting IFN response. A stochastic spatial model of viral infection and consequent IFN production and activity is constructed. Using this model, simulations of infections unde

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26

Christie, John Michael Landale. "Viral persistence in hepatitis C virus infection." Thesis, University of Southampton, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.268465.

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27

Zhang, Lei Centre for Vascular Research Faculty of Medicine UNSW. "Understanding viral-immune dynamics in HIV infection." Awarded by:University of New South Wales. Centre for Vascular Research, 2005. http://handle.unsw.edu.au/1959.4/23372.

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The HIV epidemic has caused a health crisis globally. Using mathematical and statistical tools, we have analysed and modelled data from animal models of HIV, HSV and influenza virus, in order to understand the role of neutralising antibodies (nAbs), CD4+ T cells, CTLs and APCs in HIV infection and the implications of this for HIV vaccine design. Our analysis suggests that antibody and CTL responses confer protection at different stages of HIV infection. Passive antibodies confer protection against SHIV89.6PD infection by either neutralising the initial viral inoculum or reducing the acute vira

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28

Li, Wei Beck Melinda A. "Nutritionally-induced oxidative stress and viral infection." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2006. http://dc.lib.unc.edu/u?/etd,523.

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Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2006.<br>Title from electronic title page (viewed Oct. 10, 2007). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Nutrition." Discipline: Nutrition; Department/School: Public Health.

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29

Lobbermann, Jens. "Regulation of immunity during viral lung infection." Thesis, Imperial College London, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.544288.

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30

Stevens, Kim. "Multiplicity of viral infection in brown algae." Thesis, University of Plymouth, 2014. http://hdl.handle.net/10026.1/3156.

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Brown algae are important primary producers and habitat formers in coastal environments and are believed to have evolved multicellularity independently of the other eukaryotes. The phaeoviruses that infect them form a stable lysogenic relationship with their host via genome integration, but have only been extensively studied in two genera: Ectocarpus and Feldmannia. In this study I aim to improve our understanding of the genetic diversity, host range and distribution of phaeoviruses. Sequencing and phylogenetic analysis of amplified fragments of three core phaeoviral genes (encoding major caps

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31

Manley, Grace C. A. "The roles of DUSPs in respiratory viral infection." Thesis, University of Sheffield, 2018. http://etheses.whiterose.ac.uk/19257/.

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32

Barasheed, Osamah Abdullah A. "Prevention of respiratory viral infection among Hajj pilgrims." Thesis, University of Sydney, 2020. https://hdl.handle.net/2123/23506.

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Hajj is one of the five basic tenets of Islam. Every practicing, financially and physically capable, Muslim is required to perform Hajj at least once in his/her lifetime. Each year up to three million people from more than 180 countries assemble in Mecca, Saudi Arabia, to perform Hajj pilgrimage. Severe crowding, shared accommodation, poor personal hygiene, and environmental pollution at Hajj may collectively lead to increased transmission of respiratory viruses. Influenza-like illness (ILI) is one of the most common medical presentations to primary care, mostly due to viral infection, in whic

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33

Caney, Sarah Madeline Amanda. "Mucosal immunopathogenesis of feline immunodeficiency virus infection." Thesis, University of Bristol, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.341499.

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34

Eleftheriou, Androulla Anastasiou. "Viral infection among Thalassaemia major patients with special reference to Hepatitis C virus infection." Thesis, University of London, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.265118.

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35

Dhenni, Rama B. S. "Role of Granzyme B in the Susceptibility to Secondary Bacterial Infection after Viral Infection." University of Cincinnati / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1460446984.

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36

Leong, Iona Tuling. "Oral non-Hodgkin's lymphomas and Epstein-Barr viral infection." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape17/PQDD_0028/MQ34046.pdf.

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37

Dovigi, Allan Webster-Cyriaque Jennifer. "HIV salivary gland disease a role for viral infection /." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2005. http://dc.lib.unc.edu/u?/etd,297.

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Thesis (M.S.)--University of North Carolina at Chapel Hill, 2006.<br>Title from electronic title page (viewed Oct. 10, 2007). "... in partial fulfillment of the requirements for the degree of Master of Science in the Department of Oral and Maxillofacial Pathology School of Dentistry." Discipline: Oral and Maxillofacial Pathology; Department/School: Dentistry.

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38

Karlsson, Annika C. "Viral dynamics and evolution following primary HIV-1 infection /." Stockholm, 2000. http://diss.kib.ki.se/2000/91-628-4558-6/.

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39

Huang, Kenneth Hsing-Chung. "Immune correlates of viral control in chronic HIV infection." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=111908.

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There are currently an estimated 33.2 million people living with human immunodeficiency virus (HIV) worldwide. For these individuals, long-term use of combination antiretroviral therapy (cART) is not feasible for a variety of reasons including major adverse complications, multi-drug resistance, poor adherence, and high cost. Hence, development of novel therapeutic strategies that can reduce the life-long dependency on cART is highly desired. In order to develop effective therapeutic strategies such as a therapeutic vaccine, we need to have a greater understanding of the immune correlates of vi

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40

Gramoustianou, Evangelia Sophia. "Viral and host gene expression during human cytomegalovirus infection." Thesis, University College London (University of London), 2005. http://discovery.ucl.ac.uk/1444419/.

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HCMV infection is usually asymptomatic in immunocompetent hosts, but serious disease can occur in immunocompromised individuals and in congenitally infected newborns. The importance of virus fitness determinations became evident in 1976, when it was proposed that the infecting strain of HCMV is important for clinical outcome, along with the intensity and duration of viral replication. HCMV strains exhibit different levels of virulence in vivo, depending on their passage history in cell culture. High and low passage HCMV strains exhibit tropism differences in vitro, suggesting that different ti

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Jorfi, Samireh. "The role of microvesicles in cancer and viral infection." Thesis, London Metropolitan University, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.590129.

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Microvesicles are shed constitutively, or upon activation from both normal and malignant cells. Although recent studies have reported various nonlytic virus release mechanisms, this mode of virus transmission to secondary sites of infection has remained unclear. This study identified that Coxsackie virus B1 (CVB1) entry into HeLa cells results in apoptosis and production of virus-induced apoptotic microvesicles (vaMVs) by infected cells. Flow cytometery and fluorescence microscopy data illustrated that these vaMVs carry and disseminate CVB1 virions to new host cells via a non lytic MV-to-cell

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Dillon, Amanda Louise. "Protozoan grazing and viral infection of freshwater synechococcus species." Thesis, Lancaster University, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.536035.

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Jones, Joshua David. "Found in translation : tracking the ribosome during viral infection." Thesis, University of Cambridge, 2015. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.709233.

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44

Lissauer, Samantha Mary. "Modelling hepatitis C viral host interaction and co-infection." Thesis, University of Birmingham, 2018. http://etheses.bham.ac.uk//id/eprint/8774/.

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Hepatitis C Virus (HCV) is a clinically important infection that leads to chronic liver disease and Human Immunodeficiency Virus (HIV) co-infected patients have more rapid progression to severe liver disease and show higher rates of HCV vertical transmission. Hepatocytes are a highly differentiated cell type and support low level HCV replication. Most studies of the viral life cycle use de-differentiated hepatoma cell lines, which are highly permissive. The mechanism behind this difference is poorly understood. We show that dimethylsulfoxide (DMSO) differentiated Huh-7 cells have a 100-fold re

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Kauffman, Anne Kathryn Marie. "Demographics of lytic viral infection of coastal ocean vibrio." Thesis, Massachusetts Institute of Technology, 2014. http://hdl.handle.net/1721.1/90046.

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Thesis: Ph. D., Joint Program in Biological Oceanography (Massachusetts Institute of Technology, Department of Civil and Environmental Engineering; and the Woods Hole Oceanographic Institution), 2014.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references.<br>Viral predation on bacteria in the ocean liberates carbon from the particulate fraction, where it is accessible to higher trophic levels, and redirects it to the dissolved fraction, where it supports microbial growth. Although viruses are highly abundant in the ocean little is known about how their interactions wi

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Al-Juboori, M. R. "Viral and parasitic diseases in patients with HIV infection." Thesis, Сумський державний університет, 2013. http://essuir.sumdu.edu.ua/handle/123456789/32230.

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The aim of our research was to analyze the dependence of clinical manifestations of infections with viral and parasitic etiology on the background of HIV infection from the level of CD4-lymphocytes. When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/32230

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47

Lin, Adora A. "The CD4+ T cell response to CNS viral infection." University of Cincinnati / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1235330516.

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48

Moissiard, Guillaume. "Induction, suppression, amplification of RNA silencing during viral infection." Université Louis Pasteur (Strasbourg) (1971-2008), 2007. http://www.theses.fr/2007STR13023.

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L’ARN silencing est un mécanisme de régulation négative de l’expression des gènes par des interactions entre molécules d’ARN. Un ARN double-brin est découpé par Dicer en “short-interfering (si)RNA” de 21 à 24-nt incorporant un “RNA-Induced Silencing Complex”, pour guider le clivage d’ARNm cible de manière séquence spécifique. Le silencing joue un rôle important dans la lutte antivirale chez les plantes. De plus, la plupart des phytovirus produisent des protéines suppresseurs de silencing. Le silencing peut être amplifié par l’activité d’ARN-dépendante ARN polymérases (RDR) cellulaires. Nous av

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Marques, Mariana Campos. "Cellular responses to viral infection : proteostasis and innate immunity." Master's thesis, Universidade de Aveiro, 2017. http://hdl.handle.net/10773/22054.

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Mestrado em Biomedicina Molecular<br>Viruses are small opportunistic infectious agents. Virus entry, replication and assembly are dynamic and coordinated processes that require precise interactions with host components, often with cellular organelles. Hence, we proposed to study two different viruses affecting two distinct cellular surveillance mechanisms: Human Cytomegalovirus (HCMV) and Influenza A Virus (IAV) influence on the innate immune response and proteostasis, respectively. HCMV might be associated with additional long-term health consequences in human due to its ability to establish

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Hauler, Felix. "The ATPase VCP in viral infection and antiviral immunity." Thesis, University of Cambridge, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.707973.

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