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Dissertations / Theses on the topic 'Resolution of infection'

Author: Grafiati

Published: 4 June 2021

Last updated: 12 February 2022

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1

Teo, Su Hui Catherine. "Spatiotemporal resolution of global protein synthesis during herpes simplex virus infection using bioorthogonal precursors and click chemistry." Thesis, Imperial College London, 2018. http://hdl.handle.net/10044/1/63934.

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Herpes simplex virus (HSV) modulates the host cell’s proteome and transcriptome during infection to fulfil the needs of the virus for productive replication and transmission. Using bioorthogonal precursors and click chemistry, I have examined spatiotemporal aspects of global protein synthesis during single step replication and cell-to-cell transmission with results revealing new insights into the complex spatial interplay between translational control processes, protein localisation and transcription during HSV infection. For the first time, translational suppression and recovery is visualised

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2

Kheir, Saadé. "Etude d'une thérapie cellulaire par transplantation intrapulmonaire de macrophages dans le traitement d'une infection aigue à pseudomonas aeruginosa." Thesis, Université de Paris (2019-....), 2019. http://www.theses.fr/2019UNIP7085.

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Pseudomonas aeruginosa (P.a) est un bacille Gram négatif responsable d’infections chroniques associées à une mortalité élevée due à la prédilection de la bactérie à développer une résistance aux antibiotiques et l’inefficacité des thérapies actuelles. Notre groupe a montré dans un modèle d’infection aigue chez la souris, que l’élastase B (LasB), un facteur de virulence de P.a, dégrade la cytokine IL-6 et la molécule antimicrobienne Elafine et que la surexpression de ces deux médiateurs confère une protection aux souris en diminuant l’inflammation et augmentant la réparation. Les macrophages al

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3

Al_griw, Huda Hm. "Molecular detection of bloodstream pathogens in critical illness." Thesis, University of Manchester, 2012. https://www.research.manchester.ac.uk/portal/en/theses/molecular-detection-of-bloodstream-pathogens-in-critical-illness(5f143a31-3694-454c-8940-5ae434f1eb31).html.

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Background: Critically ill patients are at particular risk of developing bloodstream infection. Such infections are associated with the development of sepsis, leading to a marked increase in mortality rate. Early detection of the causative organism and appropriate antibiotic treatment are therefore critical for optimum outcome of patients with nosocomial infection. Current infection diagnosis is based on standard blood culture techniques. However, microbiological culture has a number of limitations, not least that it takes several days to confirm infection and is therefore not useful in direct

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4

Rita, Krystianelly Patrícia Pedrosa Santa. "Avaliação dos parâmetros físicos, químicos e microbiológicos do ar na unidade de terapia intensiva neonatal e no centro cirúrgico do Hospital Universitário Prof. Dr. Alberto Antunes HUPAA, Maceió-AL." Universidade Federal de Alagoas, 2010. http://repositorio.ufal.br/handle/riufal/935.

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Intensive care units (ICU) and Surgical Center are noteworthy environments, because patients with poor health that frequent these places are subjected to acquire infections from the air of these environments. The aim of this study was to evaluate the air quality during the dry and rainy seasons of air-conditioned rooms of the NICU, neonatal intensive care unit, (A, B and C) , surgical center and exterior area at the University Hospital HUPAA/UFAL, Maceió-AL, for parameters recommended by ANVISA, and identify the mycoflora found and quantify the bacteria in the air. A number of 22 points of col

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5

Nugent, Graham. "The role of wild deer in the epidemiology and management of bovine tuberculosis in New Zealand." Phd thesis, Lincoln University. Bio-Protection and Ecology Division, 2005. http://theses.lincoln.ac.nz/public/adt-NZLIU20070212.130927/.

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The eco-epidemiology of bovine tuberculosis (Tb) in wild deer (mainly red deer Cervus elaphus) in New Zealand was investigated. Bovine Tb is caused by Mycobacterium bovis. Specific aims were to clarify the likely routes of infection in deer, and to determine the status of deer as hosts of Tb, the likely rates and routes of inter- and intra-species transmission between deer and other wildlife hosts, the role of deer in spreading Tb, and the likely utility of deer as sentinels of Tb presence in wildlife. As the possum (Trichosurus vulpecula) is the main wildlife host of Tb, the research also inc

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6

Song-Zhao, George Xiaoxi. "The role of NLRs in induction and resolution of intestinal inflammation." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:74c0e3a2-82ae-4311-8abe-21926835bc17.

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Innate immune activation is thought to play a central role in IBD pathogenesis because genetic polymorphisms in NOD2 and NLRP3, cytosolic innate immune receptors belonging to the NLR family, have been associated with IBD susceptibility. However, the mechanisms through which NLR mutations predispose to IBD remain unclear. The aim of this project was to dissect the functional roles of different NLRs in intestinal inflammation. Using the well-established DSS-induced colitis model as well as experimental models of IBD based on infection with Helicobacter hepaticus, we found that Nod2 expression wa

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7

Ozbak, Hani. "The application of High Resolution Melting Analysis (HRMA) for rapid detection of bacteria responsible for bloodstream infections." Thesis, University of Manchester, 2013. https://www.research.manchester.ac.uk/portal/en/theses/the-application-of-high-resolution-melting-analysis-hrma-for-rapid-detection-of-bacteria-responsible-for-bloodstream-infections(b3d5c15b-9541-44c2-873c-f7a32fc60282).html.

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Background: The diagnosis of bloodstream infection is a significant challenge for healthcare providers and is often associated with severe illness (sepsis) and poor outcomes. Rapid detection and identification of pathogens followed by characterisation of antibiotic resistance could help direct early treatment and improve patient care. Standard blood culture methods, which usually take 2-5 days to complete, can confirm if there is a bacteraemia or not in suspected patients. However, molecular approaches have been developed and are being increasingly investigated to overcome disadvantages of cul

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8

Blaho, Victoria Alison. "Lipid mediators in the development and resolution of experimental lyme arthritis." Diss., Columbia, Mo. : University of Missouri-Columbia, 2007. http://hdl.handle.net/10355/4819.

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Thesis (Ph. D.)--University of Missouri-Columbia, 2007.<br>The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. "May 2007" Includes bibliographical references.

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9

Tairo, Fred. "Molecular resolution of genetic variability of major sweetpotato viruses and improved diagnosis of potyviruses co-infecting sweetpotato /." Uppsala : Dept. of Plant Biology and Foresty Genetics, Swedish University of Agricultural Sciences, 2006. http://epsilon.slu.se/200605.pdf.

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10

George, Nicholas M. "Resolution of Inflammation Rescues Axon Initial Segment Disruption." VCU Scholars Compass, 2016. http://scholarscompass.vcu.edu/etd/4186.

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Axonal domains are required for proper neuron function. These domains are unstable and degenerate concurrent with the inflammation in multiple sclerosis (MS) and the inflammatory disease models experimental autoimmune encephalomyelitis (EAE) and lipopolysaccharide (LPS) induced inflammation. Previous studies from our laboratory have shown that the axon initial segment (AIS) is maintained independently of the presence of myelin, but that AIS disruption is seen in MS as well as EAE and LPS-mediated inflammation. AIS loss can be interrupted in the early stage of EAE using the anti-inflammatory dr

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11

Cox, Jr Ruan Rollin. "Aspirin Triggered Resolution Phase Interaction Product D1: A Novel Treatment for Hyperoxic Acute Lung Injury." Scholar Commons, 2015. http://scholarcommons.usf.edu/etd/5931.

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Acute Lung injury (ALI) and the more severe acute respiratory distress syndrome (ARDS) are respiratory maladies that present immense clinical challenges. ALI affects 200,000 individuals annually and features a 40% mortality rate. ALI can be initiated by both pathogenic and sterile insults originating locally in the lungs or systemically. While immense research has been poured into this disease in an effort to find a therapeutic strategy, the heterogeneously diffuse nature of the disease has not yielded a cure for the disease. Death from this disease is strongly attributed to reduced gas exchan

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12

Viecili, Raqueli Biscayno. "Evolução da função pulmonar em crianças e adolescentes com bronquiolite obliterante pós-infecciosa." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2015. http://hdl.handle.net/10183/143087.

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Introdução: A Bronquiolite Obliterante Pós-infecciosa (BOPI) é uma síndrome clínica rara e grave caracterizada por sinais e sintomas persistentes de obstrução crônica das pequenas vias aéreas. Objetivos: o objetivo do presente estudo é avaliar a evolução da função pulmonar de uma coorte de acompanhamento de pacientes com BOPI de Porto Alegre, Brasil. Métodos: Foram incluídas crianças, adolescentes com BOPI, de ambos os sexos, em acompanhamento de longo prazo nos ambulatórios de pneumologia pediátrica dos hospitais da Criança Santo Antônio e Materno-Infantil Presidente Vargas, ambos de Porto Al

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13

Kim, Hana. "Spatial Surveillance of Infectious Disease Intervention with Related Factors for a Population Living in Underserved Areas in sub-Saharan Africa." University of Cincinnati / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1617108703543143.

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14

Inamdar, Kaushik. "Role of I-BAR proteins and membrane curvature in HIV-1 assembly and release." Thesis, Montpellier, 2020. http://www.theses.fr/2020MONTT032.

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Lors de l'assemblage et du bourgeonnement du VIH, la membrane plasmique subit une courbure entraînée par l'auto-assemblage du VIH-1 Gag au site d'assemblage vers l'extérieur de la cellule. Cependant, la multimérisation de Gag peut ne pas être suffisante et Gag peut avoir besoin de recruter des facteurs cellulaires pour induire une courbure de membrane locale. Nous avons récemment rapporté que la libération de particules de VIH-1 Gag dépendait de l'activation de la voie de signalisation Rac1 / IRSp53 / Wave2 / Arp3 dans les cellules Jurkat T et les lymphocytes sanguins primaires. Ce complexe ce

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15

Hansen, Sören [Verfasser], El Wahed Ahmed [Akademischer Betreuer] Abd, El Wahed Ahmed [Gutachter] Abd, and Jens [Gutachter] Tetens. "High resolution differentiation of infectious agents at the level of antibody and nucleic acid by using peptide microarray and nanopore sequencing / Sören Hansen ; Gutachter: Ahmed Abd El Wahed, Jens Tetens ; Betreuer: Ahmed Abd El Wahed." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2019. http://d-nb.info/119297493X/34.

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Hansen, sören [Verfasser], El Wahed Ahmed [Akademischer Betreuer] Abd, El Wahed Ahmed [Gutachter] Abd, and Jens [Gutachter] Tetens. "High resolution differentiation of infectious agents at the level of antibody and nucleic acid by using peptide microarray and nanopore sequencing / Sören Hansen ; Gutachter: Ahmed Abd El Wahed, Jens Tetens ; Betreuer: Ahmed Abd El Wahed." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2019. http://d-nb.info/119297493X/34.

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17

Kashinskaya, Daniya. "Structural analysis and investigation of the Staphylococcus aureus ribosome and potential anticancer drugs." Thesis, Strasbourg, 2017. http://www.theses.fr/2017STRAJ110/document.

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Les ribosomes sont des complexes ribo-nucléoprotéiques qui lisent l'ARNm pour synthétiser les protéines. Il a été démontré que les inhibiteurs de la synthèse des protéines eucaryotes ont un potentiel thérapeutique important pour traiter un large éventail de cancers humains. Récemment, nous avons publié une étude multidisciplinaire dans laquelle nous démêlons le mécanisme d'action du chlorolissoclimide (CL), un composé qui partage la similarité chimique avec le cycloheximide (CHX), mais qui présente une cytotoxicité inférieure prometteuse. Nous nous sommes intéressés aux nouveaux types d'intera

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18

Thompson, James Russell. "Imaging the assembly of the Staphylococcal pore-forming toxin alpha-Hemolysin." Thesis, University of Oxford, 2009. http://ora.ox.ac.uk/objects/uuid:e320004a-6118-4dac-af2a-eca6e90be7ac.

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Alpha-hemolysin is a pore-forming toxin secreted by pathogenic Staphylococcus aureus. Its spontaneous oligomerization and assembly into a trans-bilayer beta-barrel pore is a model for the assembly of many other pore-forming toxins. It is studied here in vitro as a means to probe general membrane protein oligomerization and lipid bilayer insertion. This thesis details the results of experiments to develop and implement a novel in vitro lipid bilayer system, Droplet-on-Hydrogel Bilayers (DHBs) for the single-molecule imaging of alpha-hemolysin assembly. Chapter 2 describes the development of DHB

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19

Glushonkov, Oleksandr. "Imagerie de fluorescence à haute résolution : étude de la localisation nucléolaire de la protéine de la nucléocapside du VIH." Thesis, Strasbourg, 2018. http://www.theses.fr/2018STRAJ028/document.

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Au cours de ce travail de thèse expérimental, nous nous sommes intéressés à l’étude de la localisation nucléaire et nucléolaire de la protéine de la nucléocapside (NC) du VIH-1. Des études antérieures menées au laboratoire avaient mis en évidence une très forte accumulation de la NC dans les nucléoles. Ce compartiment nucléaire est connu pour être ciblé par de nombreux virus afin de promouvoir leur réplication. Des expériences de microscopie électronique avaient révélé la structure complexe du nucléole et montré qu’il est composé de trois sous-compartiments : les centres fibrillaires, le compa

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20

Reaiche, Georget Yacknisa. "Characterisation of the events involved in the resolution of acute duck hepatitis B virus infection." 2008. http://hdl.handle.net/2440/50449.

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The human hepatitis B virus (HBV) is the prototype member of the Hepadnaviridae family of viruses. Various other hepadnaviruses are used as models to study human HBV infections as all Hepadnaviridae family members have similar virus structure and replication strategies. The studies performed and described in this thesis were carried out using duck hepatitis B virus (DHBV) infection of Pekin ducks as a model system. Hepadnavirus infections can have either an acute or a chronic outcome. The factors that contribute to these outcomes include the immune response, the age of the host at the time of

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21

Chang, Shy Shin, and 張詩鑫. "Detection of bacterial infection by the combined use of real-time PE-PCR and high-resolution melting analysis." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/08105975222447250420.

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博士<br>長庚大學<br>臨床醫學研究所<br>103<br>Sepsis remains to be the leading cause of mortality in critical care patients. Early identification of causative pathogen in sepsis patients can improve clinical outcome, and the current gold standard is to use blood culture. However, blood culture is often not effective in identifying the pathogens in three common types of sepsis patients: (I) patients that have been recently treated with antibiotics before blood culture; (II) patients that have cytokine disorder instead of microbial infection; (III) patients that are infected with pathogens that are not easily

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22

Balihar, Karel. "Dysfunkce gastrointestinálního traktu u kriticky nemocných." Doctoral thesis, 2015. http://www.nusl.cz/ntk/nusl-334638.

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Multiorgan dysfunction syndrom is the major driving pathophysiological mechanism of morbidity and mortality in critically ill patients. Gastrointestinal dysfunction usually develops as a result critical illness and it is believed to play a key role in the development and progression of multiple organ dysfunction. Moreover, any primary disorder of the gastrointestinal tract, if severe enough, can lead to a critical state and secondary multiorgan dyfunction. Despite intensive experimental and clinical research, reliable tools for monitoring and evaluation of the severity of gastrointestinal dysf

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23

Hansen, Sören. "High resolution differentiation of infectious agents at the level of antibody and nucleic acid by using peptide microarray and nanopore sequencing." Thesis, 2019. http://hdl.handle.net/21.11130/00-1735-0000-0003-C18C-5.

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24

Pelletier, Sandy. "Définition des interactions entre l’immunité innée et adaptative pendant l’infection aiguë par le virus de l’hépatite C (VHC)." Thèse, 2013. http://hdl.handle.net/1866/9182.

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La majorité des individus exposés au virus de l’hépatite C (VHC) développent une infection chronique. Une réponse immunitaire adaptative forte et soutenue est associée avec la guérison spontanée du VHC, mais les mécanismes sous-jacents demeurent mal définis. Le rôle des cellules NK et des cellules dendritiques (DC) dans la guérison spontanée du VHC est encore méconnu. Les cellules NK sont la population effectrice la plus importante de l’immunité innée car elles tuent les cellules infectées et sécrètent diverses cytokines. Les DC reconnaissent des agents infectieux et elles sont les première

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25

Gadina, Milton. "The impact of HIV/AIDS on the human security of households in Bulawayo." Thesis, 2009. http://hdl.handle.net/10413/7943.

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This qualitative research sought to examine the actual impact of HIV/AIDS on the human security of households in Bulawayo. The two research questions in this study where, how does HIV/AIDS affect the seven areas of human security? and has the economic crisis in Zimbabwe increased the impact of HIV/AIDS on households? This study utilized both primary and secondary data in which the later was consulted in constructing the literature review and to address specific aims one and two. These specific aims were: to assess the human security conditions in Zimbabwe and to examine the potential impact of

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26

Lee, Cheng-Chung, and 李政忠. "Studies of Virus Structure and Antiviral Strategies: (1) Crystal Structure of Infectious Bursal Disease Virus VP2 Subviral Particle at 2.6 Å Resolution: Implications in Virion Assembly and Immunogenicity (2) Structural Basis of Metal-conjugated Comp." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/65174589540798115706.

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博士<br>國立陽明大學<br>生化暨分子生物研究所<br>96<br>Crystal Structure of Infectious Bursal Disease Virus VP2 Subviral Particle at 2.6 Å Resolution: Implications in Virion Assembly and Immunogenicity Abstract Infectious bursal disease virus (IBDV) is responsible for the hightly contagious and immunosuppressive disease in young chicken. The structural protein VP2 of IBDV spontaneously forms a dodecahedral T=1 subviral particle (SVP), and is a primary immunogen of the virus, understand of its structure is efficient for vaccine development. In this study, the structure of IBDV SVP was determined in a cubic cryst

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27

Berze, Ottilia E. "Assessing foresight to advance management of complex global problems." Thesis, 2019. http://hdl.handle.net/1828/10713.

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Many people do not like thinking about the future. If they do, over 50% of Canadians think “our way of life” (p. 7) will end within 100 years and over 80% of Canadians think “we need to change our worldview and way of life if we are to create a better future for the world” (Randle & Eckersley, 2015, p. 9). There is a good reason for this. Alarms have sounded over global urgent complex problems with potential for catastrophic consequences such as the development of artificial intelligence, climate change, mass extinction, nuclear war and pandemics (Marien & Halal, 2011). Society is also increas

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