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Journal articles on the topic 'Respiratory organs Diseases Immunological aspects'

Author: Grafiati

Published: 4 June 2021

Last updated: 31 January 2023

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1

Petrov, V. I., A. V. Ponomareva, I. V. Ivakhnenko, O. V. Razvalyaeva, B. A. Meshrqi, and V. I. Statsenko. "ETIOPATHOGENETIC ASPECTS OF LIVER INJURY IN PATIENTS WITH COVID-19." Journal of Volgograd State Medical University 76, no. 4 (December 28, 2020): 9–15. http://dx.doi.org/10.19163/1994-9480-2020-4(76)-9-15.

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Infection caused by the new coronavirus SARS-CoV-2 initially associated with respiratory damage and the development of respiratory symptoms. However, it was subsequently shown that COVID-19 can be considered as a systemic inflammatory process with multiple organ damage. One of the most frequent extra pulmonary manifestations of SARS-CoV-2 infection is liver damage. Several factors of influence on the liver in COVID-19 are currently being considered: viral immunological damage, hypoxia, systemic inflammatory process, drug toxicity and progression of existing liver diseases. This review is devot

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Trukhan, D. I. "Disorders of intestinal microbiocenosis: expanding the application of probiotics." Meditsinskiy sovet = Medical Council, no. 7 (May 14, 2022): 132–43. http://dx.doi.org/10.21518/2079-701x-2022-16-7-132-143.

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The problem of interaction between a person and the intestinal microbiome is surrounded by many secrets and mysteries. The bacterial flora of the gastrointestinal tract has a local and systemic effect not only on the digestive system, but also on the entire body as a whole. Numerous studies have proved the pathogenetic relationship of the state of the intestinal biocenosis not only with diseases of the gastrointestinal tract, but also with pathological processes from other organs and systems of the body. In terms of its role in maintaining homeostasis, the intestinal microflora is not inferior

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Alagawany, Mahmoud, Shaaban S. Elnesr, Mayada R. Farag, Mohamed E. Abd El-Hack, Asmaa F. Khafaga, Ayman E. Taha, Ruchi Tiwari, et al. "Use of Licorice (Glycyrrhiza glabra) Herb as a Feed Additive in Poultry: Current Knowledge and Prospects." Animals 9, no. 8 (August 7, 2019): 536. http://dx.doi.org/10.3390/ani9080536.

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Supplementation of livestock and poultry diets with herbal plants containing bioactive components have shown promising reports as natural feed supplements. These additives are able to promote growth performance and improve feed efficiency, nutrient digestion, antioxidant status, immunological indices, and poultry health. Several studies have used complex herbal formulas with the partial inclusion of licorice. However, the individual use of licorice has been rarely reported. The major problem of the poultry industry is the epidemiological diseases, mainly confined to the respiratory, digestive,

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Malik, Aniko E., Thomas B. Issekutz, and Beata Derfalvi. "The Role of Type III Interferons in Human Disease." Clinical and Investigative Medicine 44, no. 2 (June 14, 2021): E5–18. http://dx.doi.org/10.25011/cim.v44i2.36622.

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Purpose: This literature review summarizes the main immunological characteristics of type III interferons (IFN) and highlights the clinically relevant aspects and future therapeutic perspectives for these inflammatory molecules.  Source: Relevant articles in PubMed MEDLINE from the first publication (2003) until 2020. N=101 articles were included in this review.  Principal findings: Type III IFNs represent a relatively newly described inflammatory cytokine family. Although they induce substantially similar signalling to the well-known type I IFNs, significant functional

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Popko, S. S., and V. M. Yevtushenko. "Dynamics of quantitative changes of diffuse lymphoid tissue cells of bronchi and lungs of guinea pigs sensitized with ovalbumin." Morphologia 15, no. 2 (December 21, 2021): 53–58. http://dx.doi.org/10.26641/1997-9665.2021.2.53-58.

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Background. There is a progressive increase of respiratory allergic diseases nowadays in the world, made it necessary to study the participation of the components of the immune system in these processes. From the point of view of modern aspects about the organs of the immune system, interesting are the patterns of morphogenesis and function of bronchus associated lymphoid tissue, occupied a special place in the immunological protection of the body due to the large area of contact with various antigens. Morphogenesis and reactive changes in the local immunity in respiratory system in conditions

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Sazhin, A. V., V. A. Petukhov, T. V. Nechay, G. B. Ivakhov, E. A. Stradymov, A. I. Akperov, and A. A. Rubtsov. "MICROBIOLOGICAL AND IMMUNOLOGICAL ASPECTS OFPATHOGENESISOFACUTE APPENDICITIS." Novosti Khirurgii 29, no. 2 (April 21, 2021): 221–33. http://dx.doi.org/10.18484/2305-0047.2021.2.221.

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Obstruction of the lumen of the appendix is still considered to be the main cause of acute appendicitis (including feces), followed by the increased intraluminal pressure, the development of ischemia and mucosal hypoxia of the appendix, ulceration, violation of the mucous barrier and the development of necrosis. A sufficient number of scientific facts have been accumulated completely refuting this postulate. Current fundamental achievements in molecular biology, biochemistry, etc. did not become the basis for a clinical revision of the ancient well-established theories and concepts of the etio

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Revyakina, V. A., and N. G. Mashukova. "Allergic diseases of the upper respiratory airways in children." Russian Journal of Allergy 9, no. 3 (December 15, 2012): 41–48. http://dx.doi.org/10.36691/rja716.

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Krapić, Mia, Inga Kavazović, and Felix M. Wensveen. "Immunological Mechanisms of Sickness Behavior in Viral Infection." Viruses 13, no. 11 (November 8, 2021): 2245. http://dx.doi.org/10.3390/v13112245.

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Sickness behavior is the common denominator for a plethora of changes in normal behavioral routines and systemic metabolism during an infection. Typical symptoms include temperature, muscle weakness, and loss of appetite. Whereas we experience these changes as a pathology, in fact they are a carefully orchestrated response mediated by the immune system. Its purpose is to optimize immune cell functionality against pathogens whilst minimizing viral replication in infected cells. Sickness behavior is controlled at several levels, most notably by the central nervous system, but also by other organ

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9

Dahdah, Albert, Robert M. Jaggers, Gopalkrishna Sreejit, Jillian Johnson, Babunageswararao Kanuri, Andrew J. Murphy, and Prabhakara R. Nagareddy. "Immunological Insights into Cigarette Smoking-Induced Cardiovascular Disease Risk." Cells 11, no. 20 (October 11, 2022): 3190. http://dx.doi.org/10.3390/cells11203190.

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Smoking is one of the most prominent addictions of the modern world, and one of the leading preventable causes of death worldwide. Although the number of tobacco smokers is believed to be at a historic low, electronic cigarette use has been on a dramatic rise over the past decades. Used as a replacement for cigarette smoking, electronic cigarettes were thought to reduce the negative effects of burning tobacco. Nonetheless, the delivery of nicotine by electronic cigarettes, the most prominent component of cigarette smoke (CS) is still delivering the same negative outcomes, albeit to a lesser ex

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Kalkanov, I., and Iv Dinev. "PATHOMORPHOLOGICAL ASPECTS OF RELEVANT GASTROINTESTINAL DISEASES IN NEWBORN AND GROWING CALVES." Trakia Journal of Sciences 17, no. 4 (2019): 413–20. http://dx.doi.org/10.15547/tjs.2019.04.019.

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The emphasis of this literature overview is placed on the etiology, epidemiology, specific gross and microscopic pathological changes of the commonest gastrointestinal diseases in newborn and growing calves in dairy and beef farms. Neonatal diarrhea in calves is a multifactorial disease accompanied with high morbidity and mortality rates. It incurs considerable economic losses for cattle industry worldwide. The gastroenteritis in calves is most commonly of infectious or parasitic etiology and the most frequently involved enteropathogens are Cryptosporidium parvum, bovine rotaviruses (GRA BRV),

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Andalib, Ali Reza, and Maedeh Radandish. "Immunological and Clinical Aspects of Immune Responses to SARS-CoV-2." Journal of Qazvin University of Medical Sciences 24, no. 6 (February 1, 2020): 592–613. http://dx.doi.org/10.32598/jqums.24.6.10.

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The Coronavirus Disease 2019 (COVID-19) caused by a coronavirus named SARS-CoV-2 from the family Coronaviridae, was first reported in December 2019 in China. The disease have mild or severe symptoms such as fever, chills, cough, shortness of breath, body aches, and gastrointestinal symptoms, followed by severe inflammation, cytokine storm, acute respiratory distress syndrome, and dysfunction of other organs. In this narrative review study, the search was conducted on related studies published during January- October 2020 in Google Scholar, PubMed, Embase, and Scopus databases using the keyword

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León, Fabiola Justina Fumero, Lucas Lima Silva, Alanna Calheiros Santos, Vanessa Duarte da Costa, Juliana Custódio Miguel, Julia Trece Marques, Giselle Prado Nascimento, et al. "Immunological and virological aspects of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) and hepatitis C virus." Journal of Medical Virology 94, no. 5 (February 4, 2022): 2296–301. http://dx.doi.org/10.1002/jmv.27614.

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13

Salmasi, J. M., A. N. Kazimirskii, I. V. Kukes, G. V. Poryadin, and D. I. Pozdnyakov. "Interferoncontaining drugs: clinical, pharmacological, and immunological points of their use for respiratory diseases treatment." Meditsinskiy sovet = Medical Council, no. 11 (August 12, 2021): 210–20. http://dx.doi.org/10.21518/2079-701x-2021-11-210-220.

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Nowadays pharmacological group classified by the ATX L03AX code as immunostimulants is demand among doctors of various specialties. The main area of application of such drugs is infectious respiratory viral processes, which are associated not only with the pathogenetic action of viruses, but also with a high risk of bacterial complications. Thus, the practitioner is faced with the task of preventing such complications and choosing an immunomodulatory drug with the most pronounced pharmacodynamic properties in this regard. In Russia, there are many drugs belonging to the group of immunomodulato

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Silva, Camila Radelley Azevedo Costa da, Lisiane Vital de Oliveira, Lorenna Peixoto Lopes, Wancler Albert Gomes dos Santos, and Isabela Karine Rodrigues Agra. "Immunological aspects of coronavirus disease during pregnancy: an integrative review." Revista da Associação Médica Brasileira 66, no. 5 (May 2020): 696–700. http://dx.doi.org/10.1590/1806-9282.66.5.696.

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SUMMARY OBJECTIVE To review the immunological aspects of the 2019 coronavirus disease (COVID-19) in pregnancy, based on the scientific evidence currently available. METHODS An integrative review was performed by two independent researchers, based on the literature available in the MEDLINE (via PubMed) and LILACS databases, using the descriptors “pregnancy” and “COVID-19”. This search included articles published up until 14th April 2020 published in English, Spanish or Portuguese. After reading the articles available in their entirety, those related specifically to the immunological aspects of

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15

Vadakedath, Sabitha, Venkataramana Kandi, Ranjan K. Mohapatra, Venkata B. K. Pinnelli, Richa R. Yegurla, Praveen R. Shahapur, Vikram Godishala, et al. "Immunological aspects and gender bias during respiratory viral infections including novel Coronavirus disease‐19 (COVID‐19): A scoping review." Journal of Medical Virology 93, no. 9 (May 19, 2021): 5295–309. http://dx.doi.org/10.1002/jmv.27081.

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16

Collazo, Carmen M., Anda I. Meierovics, Roberto De Pascalis, Terry H. Wu, C. Rick Lyons, and Karen L. Elkins. "T Cells from Lungs and Livers of Francisella tularensis-Immune Mice Control the Growth of Intracellular Bacteria." Infection and Immunity 77, no. 5 (February 23, 2009): 2010–21. http://dx.doi.org/10.1128/iai.01322-08.

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ABSTRACT Parenteral and respiratory vaccinations with the intracellular bacterium Francisella tularensis have been studied using the live vaccine strain (LVS) in a mouse model, and spleen cells from immune mice are often used for immunological studies. However, mechanisms of host immunological responses may be different in nonlymphoid organs that are important sites of infection, such as lung and liver. Using parenteral (intradermal) or respiratory (cloud aerosol) vaccination, here we examine the functions of resulting LVS-immune liver or lung cells, respectively. Surprisingly, LVS was conside

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Galimov, O. V., V. U. Sataev, E. S. Galimova, S. V. Fedorov, and V. O. Khanov. "The influence of the gastrointestinal tract deseases on the process of chronic lung pathology." Experimental and Clinical Gastroenterology, no. 6 (November 21, 2022): 14–18. http://dx.doi.org/10.31146/1682-8658-ecg-202-6-14-18.

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Aim was to study the prevalence of gastrointestinal tract pathology and the state of intestinal biocenosis among bronchial asthma patients. Materials and methods: 93 patients with asthma in the exacerbation stage who had diseases of the gastrointestinal tract were examined. Instrumental, immunological, bacterial studies of the respiratory and digestive organs were carried out. The results of our study indicate a relationship between the development of bronchial asthma and gastrointestinal pathology due to negative environmental effects, stress, glucocorticosteroid therapy, changes in general a

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Suzuki, Katsuhiko. "Chronic Inflammation as an Immunological Abnormality and Effectiveness of Exercise." Biomolecules 9, no. 6 (June 7, 2019): 223. http://dx.doi.org/10.3390/biom9060223.

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Reduced levels of physical activity in people’s daily lives cause the development of metabolic syndromes or age-related disorders. Chronic inflammation is now understood to be an underlying pathological condition in which inflammatory cells such as neutrophils and monocyte/macrophages infiltrate into fat and other tissues and accumulate when people become obese due to overeating and/or physical inactivity. Pro-inflammatory mediators such as cytokines that are secreted in excess from inflammatory cells will not only lead to the development of arteriosclerosis when they chronically affect blood

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KAMASHEVA, GULNARA R., ALBINA V. SINEGLAZOVA, and EVGENII V. ARKHIPOV. "MORPHOFUNCTIONAL ASPECTS OF AGING THAT DETERMINE THE COURSE OF RESPIRATORY DISEASES IN OLD AND SENILE AGE." Bulletin of Contemporary Clinical Medicine 15, no. 2 (April 2022): 95–102. http://dx.doi.org/10.20969/vskm.2022.15(2).95-102.

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Aim. Based on an analysis of the medical literature, describe the key features of age-related organic and functional changes that potentially affect the course and therapy of respiratory diseases in elderly and senile people. Material and methods. A review of publications in the scientific and methodological literature on the problems of physiological and pathological aging, the epidemiology of somatic pathology and the peculiarities of its clinical manifestations and outcomes in the age aspect, including the relationship with the course of non-infectious and infectious respiratory diseases in

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Karmakar, Deepmala, Basudev Lahiri, Piyush Ranjan, Jyotirmoy Chatterjee, Pooja Lahiri, and Sanghamitra Sengupta. "Road Map to Understanding SARS-CoV-2 Clinico-Immunopathology and COVID-19 Disease Severity." Pathogens 10, no. 1 (December 23, 2020): 5. http://dx.doi.org/10.3390/pathogens10010005.

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SARS-CoV-2, a novel coronavirus, was first identified in Wuhan, China in December 2019. The rapid spread of the virus worldwide prompted the World Health Organization (WHO) to declare COVID-19 a pandemic in March 2020. COVID-19 discontinuing’s a global health crisis. Approximately 80% of the patients infected with SARS-CoV-2 display undetectable to mild inflammation confined in the upper respiratory tract. In remaining patients, the disease turns into a severe form affecting almost all major organs predominantly due to an imbalance of innate and adaptive arms of host immunity. The purpose of t

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Izmaylova, Oksana A., P. F. Kiku, M. V. Yarygina, V. G. Moreva, V. Yu Ananev, and A. B. Kosolapov. "Hygienic aspects of the occurrence of ecology-dependent diseases in children and adolescents of the Primorsky Krai." Hygiene and sanitation 95, no. 11 (October 28, 2019): 1075–79. http://dx.doi.org/10.18821/0016-9900-2016-95-11-1075-1079.

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With the use of the methodology of the system approach there were obtained results of the evaluation of the occurrence of ecology-dependent diseases in children and adolescents in bioclimatic zones of the Primorsky Krai. Analysis of the prevalence of the main classes of ecologically dependent diseases according to the appealability (diseases of the respiratory system, diseases of digestive organs, diseases of blood and blood-forming organs, diseases of the circulatory system, diseases of the skin and subcutaneous tissue, diseases of the genitourinary system, neoplasms, congenital anomalies, in

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Glenn, Justin D., Matthew D. Smith, Pei Xue, Yee Chan-Li, Samuel Collins, Peter A. Calabresi, Maureen R. Horton, and Katharine A. Whartenby. "CNS-targeted autoimmunity leads to increased influenza mortality in mice." Journal of Experimental Medicine 214, no. 2 (January 5, 2017): 297–307. http://dx.doi.org/10.1084/jem.20160517.

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The discovery that central nervous system (CNS)–targeted autoreactive T cells required a process of licensing in the lung revealed an unexpected relationship between these organs. The clinical and immunological significance of this finding is bidirectional in that it showed not only a mechanism by which T cells become pathogenic before entering the CNS, but also the potential for this process to influence lung immunity as well. Epidemiological studies have shown that people with multiple sclerosis (MS) suffer from increased morbidity and mortality from infectious diseases, independent of immun

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Daulet Azadbek Ugli Jumanov, Shakhlo Khamidullaevna Bakieva, Jamolbek Abdukakharovich Djuraev, Islambek Abdinasirovich Kudiyarov, and Navruz Noryigitovich Djabbarov. "Clinical and microbiological peculiarities of nose pathology and paranasal sinuses in patients with non-hospital pneumonia." International Journal of Biological and Pharmaceutical Sciences Archive 1, no. 1 (January 30, 2021): 011–15. http://dx.doi.org/10.30574/ijbpsa.2021.1.1.0017.

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This article presents the results of a comprehensive otorhinolaryngological and microbiological study of diseases of the nose and paranasal sinuses in patients with community-acquired pneumonia. These diseases are closely interconnected, since the upper and lower respiratory tract are a single whole, have structures and functions and mechanisms for the development of pathological conditions. The etiopathogenesis of bacterial inflammatory diseases of the upper and lower respiratory tract is based on the violation of the integrity of epithelial cells under the influence of respiratory viruses. U

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Nesterova, I. V., M. N. Mitropanova, S. V. Kovaleva, G. A. Chudilova, A. N. Shuvalov та V. V. Malinovskaya. "своеDifferentiated immunotherapy in the integration program for the rehabilitation of immunocompromised children with congenital cleft lip and palate". Voprosy praktičeskoj pediatrii 15, № 6 (2020): 7–17. http://dx.doi.org/10.20953/1817-7646-2020-6-7-17.

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One of the development directions of osteoimmunology is the search for new therapeutic approaches in the pathology of bone tissue, in the pathogenesis of which the interaction between the immune and bone systems plays an essential role. In children with congenital cleft lip and palate (CCLP), the physiological deficiency of the immune system (IS) and its anatomical disorders lead to intense tension in the immature mechanism for maintaining immune homeostasis, which is accompanied by clinical features of immunodeficiency in the form of recurrent viral, bacterial and fungal infectious and inflam

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Hassan, Wassan Nori, Mazin A. A. Najm, Alaa Hussein Hasan, and Khulood H. Oudah. "Immunological aspects of Alpha 1 Antitrypsin in COVID-19 infection among the Populace and Pregnant Women." AL-Kindy College Medical Journal 17, no. 1 (April 30, 2021): 8–13. http://dx.doi.org/10.47723/kcmj.v17i1.242.

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Since the COVID-19 pandemic alarm was made by the severe acute respiratory syndrome (SARS)-coronavirus (CoV) 2, several institutions and agencies have pursued to clarify the viral virulence and infectivity. The fast propagation of this virus leads to an unprecedented rise in the number of cases worldwide. COVID-19 virus is exceptionally contagious that spreads through droplets, respiratory secretions, and direct contact. The enveloped, single-stranded RNA virus has a specific envelop region called (S) region encoding (S protein) that specifically binds to the host cell receptor. Viral infectio

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Alatorskikh, A. E., P. V. Fedorych, L. V. Grechanska, and S. B. Koval. "BACTERIAL VAGINOSIS: A LOOK AT THE PROBLEM. REVIEW OF LITERARY SOURCES." Dermatology and Venerology, no. 4 (2020): 8–11. http://dx.doi.org/10.33743/2308-1066-2020-4-8-11.

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One of the leading diseases of the genitourinary system in women of reproductive age is occupied by infectious diseases that are associated with changes in the normal biocenosis of the vagina. It is these changes with a shift in the composition of the vaginal microflora towards anaerobic and microaerophilic opportunistic pathogens that are the background on which inflammatory diseases of the genitourinary system of women are able to develop almost without hindrance. The literature suggests that the diversity of the spectrum of microorganisms that are associated with bacterial vaginosis can com

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Shcherba, О. A., L. D. Lastovetskaya, V. O. Polovynka, and V. A. Shako. "Clinical aspects of associated candidosis-herpetic vulvovaginitis." HEALTH OF WOMAN, no. 7(143) (September 30, 2019): 85–89. http://dx.doi.org/10.15574/hw.2019.143.85.

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Inflammatory processes of the female genital organs account for 55-70% of cases in the structure of all gynecological diseases, of which 40-50% are vaginal infections. Despite a significant amount of scientific research and the latest antibacterial agents, the incidence of inflammatory diseases does not tend to decrease. Candidiasis and herpes are one of the most widespread infections of the person with the chronic nature of a current and a long persistence of the agent. It is important to consider psychological consequences of infection. The objective: of the study was to study the features o

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Todorovic-Djilas, Ljiljana, Tijana Icin, Jovanka Novakovic-Paro, and Ivana Bajkin. "Autoimmune thyroid disease and other non-endocrine autoimmune diseases." Medical review 64, no. 3-4 (2011): 183–87. http://dx.doi.org/10.2298/mpns1104183t.

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Introduction, Autoimmune diseases are chronic conditions initiated by the loss of immunological tolerance to self-antigens. They constitute heterogeneous group of disorders, in which multiple alterations in the immune system result in a spectrum of syndromes that either target specific organs or affect the body systematically. Recent epidemiological studies have shown a possible shift of one autoimmune disease to another or the fact that more than one autoimmune disease may coexist in a single patient or in the same family. Numerous autoimmune diseases have been shown to coexist frequently wit

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Untersmayr, Eva, Elisabeth Förster-Waldl, Michael Bonelli, Kaan Boztug, Patrick M. Brunner, Thomas Eiwegger, Kathrin Eller, et al. "Immunologically relevant aspects of the new COVID-19 vaccines—an ÖGAI (Austrian Society for Allergology and Immunology) and AeDA (German Society for Applied Allergology) position paper." Allergo Journal International 30, no. 5 (June 18, 2021): 155–68. http://dx.doi.org/10.1007/s40629-021-00178-2.

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Summary Background The vaccines against the coronavirus disease 2019 (COVID-19) approved in the European Union represent a decisive step in the fight against the pandemic. The application of these available vaccines to patients with pre-existing immunological conditions leads to a multitude of questions regarding efficacy, side effects and the necessary patient information. Results This review article provides insight into mechanisms of action of the currently available severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines and summarises the current state of science as well as

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Vlasova, Galina V., and Pavel V. Pavlov. "Age aspects of the course of chronic otitis media with cholesteatoma in children (clinical and immunological characteristics)." Pediatrician (St. Petersburg) 10, no. 5 (January 28, 2020): 13–18. http://dx.doi.org/10.17816/ped10513-18.

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Cholesteatoma of the middle ear is the disease, the course and prognosis of which can not be considered without taking into account the patients age. In pediatric otorhinolaryngology, such patients require special attention due to the aggressiveness of cholesteatoma in children. The rapid growth and a high number of recurrences after surgical treatment are features of the course of this disease in children. The causes of the aggressiveness of this disease in children have not been studied. Objective: to identify clinical and immunological features in children with middle ear cholesteatoma in d

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Lenaerts, L., E. Verbeken, E. De Clercq, and L. Naesens. "Mouse Adenovirus Type 1 Infection in SCID Mice: an Experimental Model for Antiviral Therapy of Systemic Adenovirus Infections." Antimicrobial Agents and Chemotherapy 49, no. 11 (November 2005): 4689–99. http://dx.doi.org/10.1128/aac.49.11.4689-4699.2005.

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ABSTRACT The importance of human adenovirus infections in immunocompromised patients urges for new and adequate antiadenovirus compounds. Since human adenoviruses are species specific, animal models for systemic adenovirus infections rely on a nonhuman adenovirus. We established mouse adenovirus type 1 (MAV-1) infection of BALB/c SCID mice as a model for the evaluation of antiadenovirus therapy. In vitro studies with mouse embryonic fibroblasts pointed to the acyclic nucleoside phosphonate cidofovir and the N-7-substituted acyclic derivative 2-amino-7-(1,3-dihydroxy-2-propoxymethyl)purine (S-2

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Soleymaninejadian, Ehsan, Paola Zelini, Irene Cassaniti, Fausto Baldanti, Mattia Dominoni, Andrea Gritti, and Barbara Gardella. "Immunological Aspects of Human Papilloma Virus-Related Cancers Always Says, “I Am like a Box of Complexity, You Never Know What You Are Gonna Get”." Vaccines 10, no. 5 (May 6, 2022): 731. http://dx.doi.org/10.3390/vaccines10050731.

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The human papillomavirus (HPV) can cause different cancers in both men and women. The virus interferes with functions of the cervix, vulva, vagina, anus in the anogenital area, breast, and head and neck cancer due to the local lesions. The tumors lead to death if not treated as a result of distant metastasis to internal organs and brain. Moreover, HPV attenuates the immune system during chronic infection and releases viral antigens into the tumor microenvironment. The tumors know how difficult is to win the battle with a strong united army of immune cells that are equipped with cytokines and e

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Xanthinaki, AA, C. Donta, V. Gatou, and C. Tsichlakis. "Hyalinosis Cutis et Mucosae: Diagnosis Based on Oral Manifestations – Report of a Case." Journal of Clinical Pediatric Dentistry 33, no. 2 (December 1, 2008): 171–74. http://dx.doi.org/10.17796/jcpd.33.2.u2v6362312467465.

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Hyalinosis cutis et mucosae is a rare, autosomal recessive disorder characterized by diffuse deposition of a hyaline-like material in the skin and mucous membrane of the oral cavity, upper respiratory tract, and internal organs. In the first weeks of life it begins with typical hoarseness due to hyaline deposits in the larynx. Rough, yellowish-white papular deposits in the skin and the oral mucosa usually develop during childhood. The etiology and pathogenesis are unknown and the treatment is only symptomatic. A 14-year old boy developed several typical clinical features of the disease since b

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Расим гызы Гаджиева, Ф. "Medico-Social Aspects of Early Postpartum Complications." Репродуктивное здоровье. Восточная Европа, no. 2 (June 9, 2022): 199–209. http://dx.doi.org/10.34883/pi.2022.12.2.005.

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Введение. Сохранение репродуктивной функции – одна из главных задач современной практической и научной медицины. Одной из основных причин нарушения репродуктивного здоровья являются послеродовые инфекционно-воспалительные осложнения.Материалы и методы. Для изучения факторов риска развития воспалительного процесса были обследованы 150 родильниц, которые были разделены на две группы: основная – родильницы с развившимися послеродовыми воспалительными осложнениями (n=100), группа сравнения – родильницы с физиологическим течением послеродового периода (n=50). Средний возраст родильниц по группам со

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Mishin, Vladimir Yu, Anastasiia V. Mishina, Dmitriy A. Lezhnev, Aleksandr L. Sobkin, Nаtalya V. Sergeeva, Aleksandr S. Kononets, and Irina Yu Babaeva. "The effect of a new coronavirus infection (COVID-19) on clinical and radiological manifestations in patients with comorbidity of respiratory tuberculosis, HIV-infection and opportunistic lung diseases: prospective study design." Consilium Medicum 24, no. 3 (May 19, 2022): 150–56. http://dx.doi.org/10.26442/20751753.2022.3.201505.

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Aim. To study the features of clinical and radiological manifestations and diagnosis of COVID-19, respiratory tuberculosis and opportunistic lung infections (OIL) coinfection in patients with late stages of HIV-infection with immunodeficiency. Materials and methods. The study included 29 patients with COVID-19 coinfection, respiratory tuberculosis and opportunistic lung infections in the late stages of HIV-infection with immunodeficiency (group 1) and 29 patients similar in all parameters without COVID-19 (group 2). All patients were underwent clinical and laboratory, radiation and bronc

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Sinitsyn, M. V., M. N. Reshetnikov, B. G. Barskiy, T. I. Abu Arqoub, E. I. Pozdnyakova, and D. V. Plotkin. "DIAGNOSTIC SURGERY IN HIVINFECTED PATIENTS WITH DAMAGE OF CHEST ORGANS." HIV Infection and Immunosuppressive Disorders 10, no. 2 (July 8, 2018): 96–102. http://dx.doi.org/10.22328/2077-9828-2018-10-2-96-102.

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The current epidemiological situation in the world, characterized by a constant increase in the number of HIV-infected. The steady progression of HIV infection, even in the presence of antiretroviral therapy (ART), is accompanied by the development of opportunistic diseases. Tubercolosis most often affects patients with HIV infection, as the risk of their illness is 20–37 times higher. Basically, radiation tests and immunological tests are used for the diagnostic of tuberculosis. The main diagnostic criterion for establishing the diagnosis of tuberculosis is detection of the causative agent (M

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Kulchenko, N. G. "Epidemiology of kidney disease in patients with COVID-19." Research and Practical Medicine Journal 7, no. 3 (September 12, 2020): 74–82. http://dx.doi.org/10.17709/2409-2231-2020-7-3-7.

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At the turn of 2019–2020, humanity was struck by a new viral infection SARS-CoV-2 (COVID-19), which quickly spread in many countries and reached the scale of a pandemic. A feature of the SARS-CoV-2 virus (COVID-19) is it’s high contagiousness, virulence and tropism to many cells of human organs. Human infection primarily occurs through the respiratory tract. Then, getting into the respiratory divisions, SARS-CoV-2 (COVID-19) can enter the blood and interact with cells of other organs. It is already known that COVID-19 uses the angiotensin converting enzyme type 2 (ACE2) receptor to enter the c

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Zemlyanova, Marina A., Nina V. Zaitseva, Juliya V. Koldibekova, Olga Yu Ustinova, and Olga A. Kobjakova. "Substantiation of marker indicators of diseases of the respiratory organs and the blood system in children with elevated blood levels of copper, nickel and chromium." Hygiene and sanitation 101, no. 11 (November 30, 2022): 1347–53. http://dx.doi.org/10.47470/0016-9900-2022-101-11-1347-1353.

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Introduction. An urgent hygienic problem in regions with intensive industrial development is inadequate air quality, which causes unacceptable risks of developing somatic diseases among the population in their places of permanent residence. The purpose of the study is to substantiate the associative relationships of indicators of negative effects on the respiratory organs and the blood system with an elevated blood content of copper, nickel and chromium in children. Materials and methods. A hygienic assessment of the quality of ambient air in residential buildings was carried out, the risk was

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Fitzgerald, Robert S., and Asuncion Rocher. "Physiology and Pathophysiology of Oxygen Sensitivity." Antioxidants 10, no. 7 (July 12, 2021): 1114. http://dx.doi.org/10.3390/antiox10071114.

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Oxygen is an essential requirement for metabolism in mammals and many other animals. Therefore, pathways that sense a reduction in available oxygen are critical for organism survival. Higher mammals developed specialized organs to detect and respond to changes in O2 content to maintain gas homeostasis by balancing oxygen demand and supply. Here, we summarize the various oxygen sensors that have been identified in mammals (carotid body, aortic bodies, and astrocytes), by what mechanisms they detect oxygen and the cellular and molecular aspects of their function on control of respiratory and cir

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Kryukov, E. V., K. V. Zhdanov, K. V. Kozlov, V. Yu Kravtsov, O. V. Mal’tsev, V. S. Sukachev, P. I. Miklush, et al. "Electron microscopic changes in the nasal membrane of patients with COVID-19 depending on the clinical form and the period of the disease." Journal Infectology 13, no. 2 (July 14, 2021): 5–13. http://dx.doi.org/10.22625/2072-6732-2021-13-2-5-13.

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Given that COVID-19 is a global public health problem and that almost all countries in the world have been severely affected by the COVID-19 pandemic, research is being actively pursued to better understand the effects of the virus on human cells. However, it is not clear what changes are observed in the cells of the main gate of infection – the mucosa of the mouth and the nose at different clinical forms and at different periods of disease. Understanding the ultra-structural cell changes of SARS-CoV-2 targets may help clarify the pathogenic aspects of infection in the lower respiratory tract.

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Ostrovskaya, G. Yu, N. V. Rozkolupa, T. A. Petrova, E. G. Kolot, and A. A. Kapustianskaya. "FREE RADICAL LIPID OXIDATION AS A LEADING MECHANISM IN DEVELPOING PERIODONTITIS." Актуальні проблеми сучасної медицини: Вісник Української медичної стоматологічної академії 20, no. 1 (April 9, 2020): 40–42. http://dx.doi.org/10.31718/2077-1096.20.1.40.

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Generalized periodontitis is a disease, which occurrence rate increases with age and manifests as a destructive inflammatory process based on the complex biochemical and pathophysiological changes. Active resorption of the alveolar ridge is influenced by both local factors and the overall body condition and systemic diseases. Development of generalized periodontitis is associated with loss of skeletal bone mass and characterized by predominance of resorption over osteosynthesis. Key moments in the pathogenesis of periodontal diseases are impairment of the dynamic balance of the prooxidate-anti

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Uskov, A. N., Yu V. Lobzin, S. V. Rychkova, I. V. Babachenko, V. V. Fedorov, L. U. Ulukhanova, and L. M. Pochinyaeva. "Course of a new coronavirus infection in children: some aspects of monitoring and analysis of mortality." Journal Infectology 12, no. 3 (August 2, 2020): 12–20. http://dx.doi.org/10.22625/2072-6732-2020-12-3-12-20.

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The work objective was to carry out the analysis of the existing in the Russian Federation monitoring of the incidence of new coronavirus infection in children and specific features of death cases caused by COVID-19 in children. Materials and methods. The analysis of the data of operative statistics presented on the sites of the governments of the regions where the incidence among children was considered within the period from April 22, 2020 to June 26, 2020, as well as the data of the Main non-staff experts in infectious diseases in children was performed. The inpatient medical documentation

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Gallardo, Felipe S., Adriana Córdova-Casanova, and Enrique Brandan. "The linkage between inflammation and fibrosis in muscular dystrophies: The axis autotaxin–lysophosphatidic acid as a new therapeutic target?" Journal of Cell Communication and Signaling 15, no. 3 (March 10, 2021): 317–34. http://dx.doi.org/10.1007/s12079-021-00610-w.

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AbstractMuscular dystrophies (MDs) are a diverse group of severe disorders characterized by increased skeletal muscle feebleness. In many cases, respiratory and cardiac muscles are also compromised. Skeletal muscle inflammation and fibrosis are hallmarks of several skeletal muscle diseases, including MDs. Until now, several keys signaling pathways and factors that regulate inflammation and fibrosis have been identified. However, no curative treatments are available. Therefore, it is necessary to find new therapeutic targets to fight these diseases and improve muscle performance. Lysophosphatid

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Wang, Fujing, Yanhui Li, Changlei Cui, Zhaoping Xue, and Haichun Ma. "Effects of Anesthetics on Barrier Tissue Function." Journal of Immunology Research 2019 (October 21, 2019): 1–5. http://dx.doi.org/10.1155/2019/5920620.

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Anesthetics have long been proven to have additional effects other than anesthesia on different organs and tissues of the human body. Barrier tissues play critical roles in human health and diseases, yet the impacts of anesthetics on barrier tissues are still not clear. This review article is aimed at summarizing different effects of anesthetics on the skin, the respiratory, and intestinal membranes from two aspects: inflammation/immunity and ischemia-reperfusion. Among volatile, intravenous, and local anesthetics, volatile anesthetics are less influential on barrier ischemia-perfusion functio

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Andreev, Alexander Alekseevich, Vitalii Donchenko, Alexander Anatolievich Gluhov, Vladislav Valeryevich Novomlinsky, Anton Petrovich Ostroushko, and Anastasia Yurievna Laptiyova. "Interleukin-2 in the Complex Treatment of Surgical Patients." Journal of Experimental and Clinical Surgery 15, no. 1 (March 23, 2022): 85–91. http://dx.doi.org/10.18499/2070-478x-2022-15-1-85-91.

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Immunotherapy for surgical diseases remains one of the urgent scientific and clinical issues. Immunodeficiency is manifested in patients with purulent wounds, pancreatic necrosis, osteomyelitis, oncological diseases, echinococcosis, gastroduodenal ulcers and other pathology. Drugs inducing interleukin-2 synthesis have shown high efficacy for the correction of immunodeficiency status. Clinical effects of rIL-2 are due to its ability to activate clonal proliferation of T- and B-lymphocytes, to enhance the effector potential of cytotoxic T-lymphocytes (CTL cells) and natural killer cells (NK cell

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Budnevsky, Andrey V., Evgeniy S. Ovsyannikov, Victoria V. Shishkina, Dmitry I. Esaulenko, Bogdan R. Shumilovich, Inessa A. Savushkina, and Nadezhda G. Alekseeva. "Possible Unexplored Aspects of Covid-19 Pathogenesis: The Role of Carboxypeptidase A3." International Journal of Biomedicine 12, no. 2 (June 5, 2022): 179–82. http://dx.doi.org/10.21103/article12(2)_ra1.

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Background: Coronavirus disease 2019 (COVID-19) is a contagious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). First reported in 2019, it has already caused more than 500 million cases worldwide. The problem of COVID-19 treatment is still relevant, and it is necessary to study in detail the pathogenesis of COVID-19, including the involvement of different immune cells and their mediators. There is increasing evidence of the important role of mast cells (MCs) and their specific protease carboxypeptidase A3 (CPA3) in the pathogenesis of COVID-19. MCs chymase and t

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Guzmán, Eduardo. "Fluid Films as Models for Understanding the Impact of Inhaled Particles in Lung Surfactant Layers." Coatings 12, no. 2 (February 19, 2022): 277. http://dx.doi.org/10.3390/coatings12020277.

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Pollution is currently a public health problem associated with different cardiovascular and respiratory diseases. These are commonly originated as a result of the pollutant transport to the alveolar cavity after their inhalation. Once pollutants enter the alveolar cavity, they are deposited on the lung surfactant (LS) film, altering their mechanical performance which increases the respiratory work and can induce a premature alveolar collapse. Furthermore, the interactions of pollutants with LS can induce the formation of an LS corona decorating the pollutant surface, favoring their penetration

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Osek, Jacek, and Kinga Wieczorek. "Listeria monocytogenes—How This Pathogen Uses Its Virulence Mechanisms to Infect the Hosts." Pathogens 11, no. 12 (December 7, 2022): 1491. http://dx.doi.org/10.3390/pathogens11121491.

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Listeriosis is a serious food-borne illness, especially in susceptible populations, including children, pregnant women, and elderlies. The disease can occur in two forms: non-invasive febrile gastroenteritis and severe invasive listeriosis with septicemia, meningoencephalitis, perinatal infections, and abortion. Expression of each symptom depends on various bacterial virulence factors, immunological status of the infected person, and the number of ingested bacteria. Internalins, mainly InlA and InlB, invasins (invasin A, LAP), and other surface adhesion proteins (InlP1, InlP4) are responsible

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Maleev, V. V., A. K. Tokmalaev, G. M. Kozhevnikova, V. P. Golub, N. A. Polovinkina, T. V. Kharlamova, V. V. Konnov, I. V. Barysheva, and K. Ch Emerole. "Hantavirus infection. Achievements and challenges." Infekcionnye bolezni 19, no. 1 (2021): 110–18. http://dx.doi.org/10.20953/1729-9225-2021-1-110-118.

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In the last two decades, a number of studies analyzing environmental, epidemiological, immunological, pathogenetic, and clinical aspects of hantavirus infection were published. Scientists are searching for effective treatments and are developing new methods of specific disease prevention. The classification of pathogens has been optimized and species names of hantaviruses have been changed. Hantavirus infection has been registered on almost all continents with different incidence. Considering the wide spread of hantavirus infection, it is rather not a feral herd infection, but a natural ubiqui

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Cheng, Vincent C. C., Susanna K. P. Lau, Patrick C. Y. Woo, and Kwok Yung Yuen. "Severe Acute Respiratory Syndrome Coronavirus as an Agent of Emerging and Reemerging Infection." Clinical Microbiology Reviews 20, no. 4 (October 2007): 660–94. http://dx.doi.org/10.1128/cmr.00023-07.

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SUMMARY Before the emergence of severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV) in 2003, only 12 other animal or human coronaviruses were known. The discovery of this virus was soon followed by the discovery of the civet and bat SARS-CoV and the human coronaviruses NL63 and HKU1. Surveillance of coronaviruses in many animal species has increased the number on the list of coronaviruses to at least 36. The explosive nature of the first SARS epidemic, the high mortality, its transient reemergence a year later, and economic disruptions led to a rush on research of the epidemiologic

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