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Dissertations / Theses on the topic 'Respiratory System Physiology'

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1

Santin, Joseph M. "Context-dependence of physiological systems: environment-physiology interactions in the respiratory control system." Wright State University / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=wright149336916471128.

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2

Hlongwana, Simangele I. "Investigating adherence of authorised prescribers to standerd treatment guidelines/essential medicine list when treating children presenting with respiratory conditions at primary health care level in the umkhanyakude health district, Kwazulu Nata." Thesis, University of Limpopo (Medunsa Campus), 2013. http://hdl.handle.net/10386/1076.

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Thesis (MSc(Med)(Pharmacy) ) -- University of Limpopo, 2013.<br>Introduction: Primary Health Care (PHC) is regarded as the first level of contact with the National Health System with health care services provided mainly by nurses with varying competences. PHC is about interaction with people thus the quality of PHC depends extensively on the competence of the people who provide it. Therefore, the way health care personnel are trained and how capacity continues to be developed is of fundamental importance to PHC. Following the Alma-Ala Declaration, policies, such as the National Drug Poli
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3

Sullivan, Kevin J. "Factors affecting the compliance of the lungs and respiratory system in newborn mammals." Thesis, McGill University, 1987. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=75372.

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The effect of lung deformation upon its mechanical properties was studied by measuring the quasi-static (Cstat) and dynamic (Cdyn) compliances of excised newborn piglet lungs deformed by a vertical pleural surface pressure gradient. Cstat was not affected by deformation. Cdyn was less than Cstat in the deformed and undeformed lungs but the difference was greater in the deformed lungs. This behavior suggests that distortion of the chest wall may increase the external (PV) work of breathing in newborns.<br>The contribution of lung viscoelasticity to the difference between Cstat and Cdyn of the u
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4

Claure, Nelson Remberto. "Microcomputer-based system for the study of the respiratory system in newborns." FIU Digital Commons, 1990. http://digitalcommons.fiu.edu/etd/2382.

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A useful understanding of the respiratory system of premature infants and the factors contributing to different physiological mechanisms and diseases requires extensive clinical research. This project is the result of a need for a fast and reliable system to process the information obtained from biological sources and to obtain results from which different hypothesis can be tested. This document presents a description of one such system and its different subsystems. It describes the biosignals of interest as well as the stages they have to go through in order to obtain an accurate and valid an
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5

Dechman, Gail Sterns. "The effect of lung volume below normal functional residual capacity on respiratory system mechanics." Thesis, McGill University, 1993. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=41568.

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This thesis examines changes in the mechanical behaviour of the canine and human respiratory systems to changes in lung volume below normal functional residual capacity (FRC). In open chested dogs lung elastance (E$ sb{ rm L}$) increased and lung resistance (R$ sb{ rm L}$) changed little with decreases in positive end-expiratory pressure (PEEP) of the ventilatory circuit. The dominance of plastoelastic lung tissue properties at low lung volumes was used to interpret the lack of change in R$ sb{ rm L}$. Computed tomography demonstrated that pleural effusion (PE) created atelectasis in dependent
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6

Thamrin, Husni. "Modelling the respiratory control system in human subjects for excercise conditions." Thesis, University of Glasgow, 2008. http://theses.gla.ac.uk/421/.

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A model is a very helpful tool to describe, interpret and explain the behaviour of a highly complex system such as the human respiratory system. The research work presented in this thesis is concerned with the development of a nonlinear dynamic simulation model of the respiratory control system in human subjects for exercise conditions. Modelling the respiratory system is not a new activity but the development of a general model that takes into account the conditions above the lactate threshold has not been attempted previously because of a number of problems that arise for these particular op
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7

Perchiazzi, Gaetano. "Artificial Neural Networks (ANN) in the Assessment of Respiratory Mechanics." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4665.

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8

Prasad, Robin. "Development of a computer simulation of the respiratory system to determine the effect of post-inspiratory braking on carbon dioxide excretion." Thesis, McGill University, 1998. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=20296.

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Post-inspiratory braking is the activation of inspiratory muscles during expiration. Although not energetically optimal, it exists for currently unexplained reasons. It has been postulated that post-inspiratory braking exists in order to maintain arterial CO2 content in a tightly regulated band. A computer simulation of the respiratory system incorporating respiratory control, respiratory mechanics, and gas exchange dynamics was developed in order to evaluate the relationship of post-inspiratory braking to arterial CO 2 content. The simulation was driven with pressure signals having varying am
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9

Walker, Janelle. "An analysis of plasticity in the rat respiratory system following cervical spinal cord injury and the application of nanotechnology to induce or enhance recovery of diaphragm function." Thesis, Wayne State University, 2016. http://pqdtopen.proquest.com/#viewpdf?dispub=10153445.

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<p> Second cervical segment spinal cord hemisection (C2Hx) results in ipsilateral hemidiaphragm paralysis. However, the intact latent crossed phrenic pathway can restore function spontaneously over time or immediately following drug administration. </p><p> WGA bound fluorochromes were administered to identify nuclei associated with diaphragm function in both the acute and chronic C2Hx models. WGA is unique in that it undergoes receptor mediated endocytosis and is transsynaptically transported across select physiologically active synapses. Comparison of labeling in the acutely injured to the
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10

Pasternyk, Stephanie Marika 1983. "Effect of extracellular matrix and mechanical strain on airway smooth muscle." Thesis, McGill University, 2009. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=111560.

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Airway remodeling in asthma includes alterations in extracellular matrix and airway smooth muscle (ASM) mass. For this study, ASM cells were obtained from rats that were challenged with ovalbumin (OVA) or saline (SAL) as control. OVA and SAL cells were seeded on plastic control (PC) or on plates coated with decorin or biglycan. OVA cell number was significantly increased versus SAL cells, for cells seeded on PC (48 h). A significant decrease in cell number was observed for both OVA and SAL cells seeded on decorin compared to PC cells (48 h). OVA cells, however, showed a more modest reduction i
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11

Assunção, Renata Pletsch. "Análise dos critérios para ajuste do suporte ventilatório da ventilação mecânica." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/5/5150/tde-06022017-085815/.

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Introdução: A assistência ventilatória adequada é imprescindível para o tratamento do paciente ventilado artificialmente. A busca por parâmetros para realizar o ajuste ótimo e que tenham aplicação fácil a beira leito como, por exemplo, métodos não-invasivos, são desejáveis. Objetivo: analisar a acurácia diagnóstica das variáveis do padrão respiratório, da P0.1 esofágica e traqueal, para o ajuste da assistência ventilatória em pressão de suporte. Métodos: Vinte e sete pacientes internados em unidade de terapia intensiva foram consecutivamente incluídos no estudo. Todos pacientes estavam no modo
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12

Sekharan, Soja. "Aged soybean (Glycine max [L.] Merrill) seeds – their physiology and vigor assessment." The Ohio State University, 2006. http://rave.ohiolink.edu/etdc/view?acc_num=osu1135809134.

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13

Pereira, De Sa Rui Carlos. "Respiration and cardio-respiratory interactions during sleep in space: influence of gravity." Doctoral thesis, Universite Libre de Bruxelles, 2008. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/210416.

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Le principal objectif de ce travail est l’étude de l’influence de la pesanteur sur la mécanique <p>respiratoire et le contrôle de la respiration, ainsi que sur les interactions cardio-respiratoires pendant les différents stades du sommeil. <p><p>Le chapitre introductif présente le contexte général et les objectifs de la thèse. Des sections abordant le sommeil, la respiration, et l’interaction cardio-respiratoire y sont présentées, résumant l’état actuel des connaissances sur les effets de la pesanteur sur chacun de ces systèmes. <p>Dans le deuxième chapitre, l’expérience “Sleep and Breathing i
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14

Ziegenfuss, Jennifer S. "Eaters of the Dead: How Glial Cells Respond to and Engulf Degenerating Axons in the CNS: A Dissertation." eScholarship@UMMS, 2012. https://escholarship.umassmed.edu/gsbs_diss/608.

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Glia, whose name derives from the original Greek word, meaning “glue,” have long been understood to be cells that play an important functional role in the nutritive and structural support of the central nervous system, yet their full involvement has been historically undervalued. Despite the strong evidence that glial reactions to cellular debris govern the health of the nervous system, the specific properties of damaged axonal debris and the mechanisms by which glia sense them, morphologically adapt to their presence, and initiate phagocytosis for clearance, have remained poorly understood. T
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15

Mason, Nicholas. "Mechanisms of altitude-related cough." Doctoral thesis, Universite Libre de Bruxelles, 2012. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209711.

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The original work presented in this thesis investigates some of the mechanisms that may be responsible for the aetiology of altitude-related cough. Particular attention is paid to its relationship to the long recognised, but poorly understood, changes in lung volumes that occur on ascent to altitude. The literature relevant to this thesis is reviewed in Chapter 1.<p><p>Widespread reports have long existed of a debilitating cough affecting visitors to high altitude that can incapacitate the sufferer and, on occasions, be severe enough to cause rib fractures (22, 34, 35). The prevalence of cough
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16

Daniel, Laura L. "Role of Ataxia Telangiectasia Mutated Kinase in the Healing Process of the Heart Following Myocardial Infarction." Digital Commons @ East Tennessee State University, 2015. https://dc.etsu.edu/etd/2504.

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Ataxia telangiectasia (AT), caused by mutations in the gene encoding ataxia telangiectasia mutated kinase (ATM), is a rare autosomal recessive disorder. AT individuals exhibit neuronal degeneration and are predisposed to cancer. Carriers of this disorder are predisposed to cancer and ischemic heart disease. Heart disease, mostly due to myocardial infarction (MI), is a leading cause of death in the US. Following MI, release of catecholamines in the heart stimulates β- adrenergic receptors (β-AR). Our lab has shown that β-AR stimulation increases ATM expression in the heart and myocytes, and ATM
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17

Xu, Kui. "The Central Nervous System Aspects of Cardiac Arrest and Resuscitation in a Rat Model of Global Ischemia." Case Western Reserve University School of Graduate Studies / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=case1270689501.

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18

Marchica, Cinzia Loreta 1984. "Allergen-induced asthma is decreased in decorin-deficient mice." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=116096.

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Decorin, is an extracellular matrix proteoglycan with important biological functions. Decorin deficiency affects collagen fibrillogenesis, airway mechanics, airway-parenchymal interdependence, and airway smooth muscle proliferation and apoptosis. We questioned whether decorin deficiency would alter allergen-induced asthma in a mouse model. Decorin-/- and decorin+/+ mice (C57Bl/6) were sensitized and challenged with ovalbumin. Control animals received saline. Responsiveness was assessed at baseline and after delivery of increasing concentrations of methacholine. Histological analyses were also
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19

Maja, Bogdan. "Uticaj ženskih polnih hormona na funkciju nosa u menstrualnom ciklusu i postmenopauzi." Phd thesis, Univerzitet u Novom Sadu, Medicinski fakultet u Novom Sadu, 2020. https://www.cris.uns.ac.rs/record.jsf?recordId=114855&source=NDLTD&language=en.

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Funkcija nosa povezana je sa različitim anatomskim, fiziolo&scaron;kim i emocionalnim faktorima. Postoji mnogo teorija koje su poku&scaron;ale da objasne efekat ženskih polnih hormona (estrogena i progesterona) na fiziologiju nosa, ali sam mehanizam njihovog dejstva jo&scaron; uvek ostaje izazov za mnoge istraživače. Prethodno je opisano da ženski polni hormoni mogu da izazovu nazalnu opstrukciju, povećavajući ekspresiju histaminskih H1 receptora i menjajući koncentraciju neurotransmitera, &scaron;to dovodi do edema nosne sluznice i modifikacije nazalnog otpora. Kada je reč o mirisnoj funkciji
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20

Tikh, Eugene I. "Regulation of Contractility by Adenosine A1 and A2A Receptors in the Murine Heart: Role of Protein Phosphatase 2A: A Dissertation." eScholarship@UMMS, 2006. https://escholarship.umassmed.edu/gsbs_diss/130.

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Adenosine is a nucleoside that plays an important role in the regulation of contractility in the heart. Adenosine receptors are G-protein coupled and those implicated in regulation of contractility are presumed to act via modulating the activity of adenylyl cyclase and cAMP content of cardiomyocytes. Adenosine A1 receptors (A1R) reduce the contractile response of the myocardium to β-adrenergic stimulation. This is known as anti adrenergic action. The A2A adenosine receptor (A2AR) has the opposite effect of increasing contractile responsiveness of the myocardium. The A2AR also appears to attenu
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21

Turquetto, Aida Luiza Ribeiro. "Avaliação cardiovascular, pulmonar e musculoesquelética em pacientes com fisiologia univentricular no período pós-operatório tardio da cirurgia de Fontan." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/5/5156/tde-01082017-091231/.

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INTRODUCÃO: A cirurgia de Fontan ou conexão cavo-pulmonar total é o último procedimento de uma estratégia estadiada, empregada no tratamento de cardiopatias congênitas complexas com ventrículo único anatômico ou funcional (também chamada de cardiopatia congênita com coração univentricular). Pacientes com um único ventrículo, situação incompatível com a vida, passaram a sobreviver até a idade adulta após a realização dessa cirurgia. A conexão direta da cavas com as artérias pulmonares, exclui do sistema circulatório o ventrículo subpulmonar, criando nesses indivíduos uma circulação do tipo univ
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22

Mussard, Chase W. "In Vitro Investigation of the Effect of Exogenous Ubiquitin on Processes Associated with Atherosclerosis." Digital Commons @ East Tennessee State University, 2016. https://dc.etsu.edu/honors/327.

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Atherosclerosis, characterized by the build-up of cholesterol, immune cells and cellular debris within arterial walls, is accelerated following myocardial infarction by poorly understood mechanisms. Ubiquitin, a small, well-studied intracellular protein involved in protein turnover via the proteasome pathway, has recently been shown to exert extracellular effects on cardiac myocytes, in vitro, and in mice undergoing myocardial remodeling. This study investigates the potential role of extracellular ubiquitin in atherosclerosis by determining its effects on two critical atherosclerotic processes
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23

Santaella, Danilo Forghieri. "Efeitos do treinamento em técnica respiratória do Yoga sobre a função pulmonar, a variabilidade da freqüência cardíaca, a qualidade de vida, a qualidade de sono e os sintomas de estresse em idosos saudáveis." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/5/5150/tde-24052011-140319/.

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Introdução: O envelhecimento está associado com a diminuição de uma série de funções, incluindo a função pulmonar, a variabilidade da freqüência cardíaca, o barorreflexo espontâneo, a qualidade de vida e de sono, assim como com o aumento de níveis de estresse. Estudos recentes sugerem que os exercícios respiratórios do Yoga podem melhorar as funções respiratória e cardiovascular, além de aumentar a qualidade de vida e de sono e reduzir os sintomas de estresse em populações de pacientes com doença pulmonar. A hipótese testada no presente trabalho é de que o treinamento respiratório do Yoga pode
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24

Bierbower, Sonya M. "ENVIRONMENTAL EFFECTS ON BEHAVIOR AND PHYSIOLOGY IN CRAYFISH." UKnowledge, 2010. http://uknowledge.uky.edu/gradschool_diss/778.

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Despite dramatic morphological differences between animals from different taxa, several important features in organization and sensory system processing are similar across animals. Because of this similarity, a number of different organisms including mammals, insects, and decapod crustaceans serve as valuable model systems for understanding general principles of environmental effects. This research examines intrinsic and extrinsic factors by behaviorally and physiologically means to identify the impact of environmental conditions on two distinct crayfish species- Procambarus clarkii (surface)
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25

Darlot, Fannie. "Neuroplasticité post-lésionnelle des voies respiratoires bulbo-spinales après lésion unilatérale cervicale de la moelle épinière." Thesis, Aix-Marseille 3, 2011. http://www.theses.fr/2011AIX30033.

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Cette thèse a comme objectif l’étude des processus de plasticité du réseau bulbo-spinal respiratoire après une lésion spinale cervicale unilatérale en C2, qui induit une interruption de la majorité des fibres respiratoires. Cette étude est réalisée par une approche de traçage de voies, couplée à une approche immunohistochimique, biochimique et électrophysiologique.La lésion latérale chronique induit dans la région sus-lésionnelle C1/C2 une diminution du nombre de fibres bulbo-spinales marquées et de la surface de la substance blanche. Nous observons cependant une augmentation du nombre de fibr
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26

Lykidis, Christos. "Cardiovascular and respiratory reflex control systems in the regulation of pulmonary blood flow and ventilation during exercise." Thesis, University of Birmingham, 2010. http://etheses.bham.ac.uk//id/eprint/610/.

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The regulation of pulmonary blood flow and ventilation during exercise is mediated by numerous factors, yet the role of certain cardiovascular and pulmonary reflex control systems is unknown. Therefore this thesis investigated the pulmonary vascular response to the activation of the muscle metaboreflex alone, and combined with activation of the muscle mechanoreflex. The ventilatory responses to the activation of the muscle metaboreflex were also studied under a background of activated ventilatory chemoreceptors. Finally the effect of increased metabolism on the ventilatory sensitivity to carbo
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27

Gezelius, Henrik. "Studies of Spinal Motor Control Networks in Genetically Modified Mouse Models." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-109889.

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28

Rariden, Brandi Scot. "Sedentary Time and the Cumulative Risk of Preserved and Reduced Ejection Fraction Heart Failure: from the Multi-Ethnic Study of Atherosclerosis." UNF Digital Commons, 2018. https://digitalcommons.unf.edu/etd/792.

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ABSTRACT Purpose: The purpose of this study was to examine the relationship between self-reported sedentary time (ST) and the cumulative risk of preserved ejection fraction heart failure (HFpEF) and reduced ejection fraction heart failure (HFrEF) using a diverse cohort of U.S. adults 45-84 years of age. Methods: Using data from the Multi-Ethnic Study of Atherosclerosis (MESA), we identified 6,814 subjects (52.9% female). All were free of baseline cardiovascular disease. Cox regression was used to calculate the hazard ratios (HR) associated with baseline ST and risk of overall heart failure (HF
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29

Koulnis, Miroslav. "Dynamics of Erythropoietic Survival Pathways In Vivo: A Dissertation." eScholarship@UMMS, 2011. https://escholarship.umassmed.edu/gsbs_diss/555.

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Erythropoiesis maintains stable tissue oxygenation in the basal state, while accelerating red cell production in anemia, blood loss or high altitude. The principal regulator of erythropoiesis is the hormone erythropoietin (Epo). In response to hypoxic stress, Epo can increase a 1000-fold, driving erythropoietic rate by up to 10-fold. It’s been suggested that survival pathways activated by the Epo receptor (EpoR) underlie its regulation of erythropoietic rate. A number of apparently redundant EpoR survival pathways were identified in vitro, raising the possibility of their functional specializa
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30

Yuan, Jiayao. "Dynamic Modeling and System Identification of the Human Respiratory System." Thesis, 2021. https://doi.org/10.7916/d8-t170-t155.

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The lungs are the primary organ of the respiratory system. Their main function is to provide freshly breathed oxygen (O²) to the blood capillaries, while taking carbon dioxide (CO²) from them and expelling it to the atmosphere. Lung conditions such as Acute Respiratory Distress Syndrome (ARDS), Idiopathic Pulmonary Fibrosis (IPF), Coronavirus Disease (COVID-19), etc., cause impaired gas exchange that is life-threatening. In this dissertation, I developed 1) a physiology-based dynamic pulmonary system to study the lung normo- and patho-physiology, and 2) a model-based constrained optimization a
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Σφυρής, Νικόλαος. "Επίδραση των δεξαμενών CO2 στην εμφάνιση ισοτοπικού άνθρακα στην εκπνοή". Thesis, 1991. http://nemertes.lis.upatras.gr/jspui/handle/10889/2790.

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32

Manzke, Till PD Dr Dr. "Expression and function of serotonin receptor isoforms in the respiratory system." Doctoral thesis, 2005. http://hdl.handle.net/11858/00-1735-0000-0006-AC76-A.

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