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Dissertations / Theses on the topic 'Response induction'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Benjamin, Richard John. "Tolerance induction with monoclonal antibodies." Thesis, University of Cambridge, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.253988.

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2

Omodho, Becky. "Early growth response gene (Egr) 2 and 3 control inflammatory responses of tolerant T cells." Thesis, Brunel University, 2016. http://bura.brunel.ac.uk/handle/2438/13516.

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This study investigated the role of tolerance induction in an inflammatory setting in regard to the early growth response genes Egr2 and Egr3. T cells robustly respond to pathogenic antigens during infection, but are tolerant to stimulation by self-antigens. The intrinsic mechanisms for self-tolerance in the periphery are still not clear. Egr2 and 3 are induced in tolerant T cells in response to antigen stimulation by NFAT-medicated tolerant signalling; however, their function in tolerant T cells is still unknown. The study demonstrated that Egr2 and 3, induced in tolerant T cells, are not dir

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3

Jawyn, Natalie. "Mechanisms of Adjuvant Induction of the Innate Immune Response." University of Akron / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=akron1302484631.

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4

Jordan, Samuel Decon. "EXAMINING THE EFFECTS OF CHANGING REINFORCEMENT SCHEDULE COMPONENTS ON PREVIOUSLY EXTINGUISHED RESPONDING." OpenSIUC, 2015. https://opensiuc.lib.siu.edu/theses/1615.

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The present study used a Microsoft Visual Basic computer program to examine the effects of changing reinforcement schedule components on response allocation following previously extinguished responding. In Experiment 1, participants allocated responses to three different colored buttons that moved around the screen after each successive click. Components were arranged such that clicking on one button resulted in reinforcer delivery on a programmed variable-interval (VI) 10 s schedule while clicking either of the other two buttons did not result in programmed reinforcer deliveries. Results of E

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5

Riese, Jens. "The nuclear response to cell signalling during Drosophila endoderm induction." Thesis, University of Cambridge, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.627337.

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6

Herschke, Florence. "Induction and amplification of the interferon response by measles virus." Lyon 1, 2007. http://www.theses.fr/2007LYO10193.

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Le virus de la rougeole induit une réponse interféron par la cellule-hôte. J'ai étudié son déclenchement, sachant qu'il repose sur la transcription de l'ARN leader codé à l'extrémité 3' du génome viral. Cet ARN est détecté par RIG-I, une ARN hélicase à boîte DExD/H. J'ai contribué à montrer que le leader est reconnu par son extrémité 5'-triphosphate libre dans le cytoplasme. RIG-I semble cependant capable de lier tous les ARN. Avec Sonia Longhi, j'ai montré que la Q299 est impliquée dans la liaison des ARN par RIG-I. J'ai alors étudié l'impact de la fusion intercellulaire, caractéristique du V

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7

Imbasi, Precious Ayebaifemi. "Induction of antioxidant response element-linked gene expression by dietary isothiocyanates." Thesis, University of Essex, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.486618.

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Oxidative damage to DNA and proteins contributes to mutation and cancer risk. A further source of DNA and protein damage is glycation by reactive endogenous dicarbonyls - particularly methylglyoxal and glyoxal. Cellular protection against oxidative damage involves up regulation of enzymes controlled transcriptionally by transcription factor nrf2 interacting with an antioxidant response element (ARE) in the promoter. Dietary isothiocyanates (ITCs) enhanced enzymatic components of the antioxidant defence by increasing the ARE-linked gene expression. This may also increase protection against dica

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8

Syed, Altaf Ahmad. "Applied Fuzzy Logic Controls for Improving Dynamic Response of Induction Machines." Connect to resource online, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=ysu1219671348.

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9

Williams, Kevin Jason. "NF- kB c-Rel dependent gene induction in the immune response." Diss., Restricted to subscribing institutions, 2008. http://proquest.umi.com/pqdweb?did=1779835231&sid=6&Fmt=2&clientId=1564&RQT=309&VName=PQD.

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10

Van, Pinxteren Laurens A. H. "Induction and characterisation of the ovine mucosal immune response to rotavirus." Thesis, University of Edinburgh, 1997. http://hdl.handle.net/1842/30034.

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The local and systemic immune response to rotavirus was investigated, both in previously exposed adult sheep and gnotobiotic lambs. Vaccines composed of rotavirus or recombinant VP6 mixed with or incorporated into ISCOMs were used to examine if one oral dose could induce a mucosal immune response and protection against subsequent challenge. Gnotobiotic lambs were vaccinated orally either with PBS/ISC, inactivated rotavirus (IRV)/ISC, recombinant VP6/ISC, or IRV alone, challenged 3 weeks later with a live virulent lamb strain, and killed 8-9 days after challenge. The immune response was measure

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11

Bawana, Niyem Mawenbe. "Thermal Response in a Field Oriented Controlled Three-phase Induction Motor." Scholar Commons, 2019. https://scholarcommons.usf.edu/etd/7740.

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The research conducted at the department of Electrical Engineering of the University of South Florida campus in Tampa only covers the electrical aspect of electric drives. However, the performance of electric machinery is significantly impacted by temperature variation. The literature review shows three main control techniques in use today in electric drives namely, Scalar control, Direct Torque control and Field Oriented control. This thesis presents a temperature rise of rotor bars, stator winding, stator core and stator frame in a running three phase field-oriented controlled induction mach

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12

Yin, Yalei. "Analysis of transgene expression profile-dependent induction of transgene-specific immune response." 京都大学 (Kyoto University), 2014. http://hdl.handle.net/2433/192152.

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13

Burkart, Alison M. "Energy Metabolism and the Induction of the Unfolded Protein Response: A Dissertation." eScholarship@UMMS, 2010. https://escholarship.umassmed.edu/gsbs_diss/502.

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White adipose plays a major role in the regulation of whole body metabolism through the storage and hydrolysis of triglycerides and by secretion of adipokines. The function of endocrine cells is highly dependent on the unfolded protein response (UPR), a homeostatic signaling mechanism that balances the protein folding capacity of the endoplasmic reticulum (ER) with the cell's secretory protein load. Here we demonstrate that the adipocyte UPR pathway is necessary for its secretory functions, and can thus play a crucial role in the control of whole body energy homeostasis. ER protein folding cap

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14

Zumbrun, Steven David. "Distinct Mechanisms Regulate Induction of Stress Effector, gadd45b." Diss., Temple University Libraries, 2008. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/23355.

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Molecular Biology and Genetics<br>Ph.D.<br>The GADD45 family of proteins consists of three small nuclear proteins, GADD45A, GADD45B, and GADD45G, which are implicated in modulating the cellular response to various types of genotoxic/physiological stress. This family of proteins has been shown to interact with and modulate the function of cell-cycle control proteins, such as p21 and cdc2/cyclin B1, the DNA repair protein, PCNA, key stress response MAP kinases, including MEKK4 (an upstream regulator of JNK kinase), and p38 kinase. Despite similarities in amino acid sequence, structure and functi

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15

Cambouropoulos, Peter. "Studies on the induction and prevention of delayed type hypersensitivity to herpes simplex virus." Thesis, University of Cambridge, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.336550.

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16

Zhang, Shu. "Effect of chitosan on the induction of DNA damage response by selenium compounds." College Park, Md.: University of Maryland, 2009. http://hdl.handle.net/1903/10019.

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Thesis (M.S.) -- University of Maryland, College Park, 2009.<br>Thesis research directed by: Dept. of Nutrition and Food Science. Title from t.p. of PDF. Includes bibliographical references. Published by UMI Dissertation Services, Ann Arbor, Mich. Also available in paper.

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17

Darlington, Barry Guy. "The response of ectoderm to mesoderm induction in early embryos of Xenopus laevis." Thesis, University of Oxford, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.329909.

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18

Khan, Deena. "Molecular Basis of Upregulation of IL-17 in Estrogen Model of Inflammation." Diss., Virginia Tech, 2012. http://hdl.handle.net/10919/77129.

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Interleukin-17 (IL-17) plays a major role in inflammation by regulating the induction of various proinflammatory genes, which aid in the recruitment and activation of neutrophils. Although IL-17 is considered to be protective in infection, overproduction of IL-17 in conditions like autoimmune diseases has been shown to aggravate these diseases and contribute to tissue injury. One of the principal focus of our laboratory is to decipher molecular mechanisms involved in inflammatory cytokine regulation and response in inflammatory disorders. To study this aspect, we employ a murine model of pro-i

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19

Mittal, Sajjan K. "Local and systemic induction of an abundant CD4+CD25+ regulatory T cell population in non-Hodgkin's lymphoma." Available from the University of Aberdeen Library and Historic Collections Digital Resources, 2009. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=26200.

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20

Mittal, Sajjan. "Local and systemic induction of an abundant CD4+CD25+ regulatory T cell population in non-Hodgkin's lymphoma." Thesis, University of Aberdeen, 2009. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=26200.

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To investigate their importance in non-Hodgkin’s lymphoma (NHL), I enumerated Treg cells in peripheral blood mononuclear cells (PBMC) and involved tissues from 30 newly diagnosed patients CD25+FoxP3+CD127<sup>low</sup>CD4+ Treg cells were increased markedly in PBMC (median=20.4% CD4 T cells, n=20) versus healthy controls (median=3.2%, n=13:<i> p</i><0.001, rank sum test) and correlated with serum lactate dehydrogenase (n=14; R<sub>s</sub>=0.79, <i>p</i><0.001) and disease stage. I documented poor proliferation of T cells with mitogen ConA and almost none with recall antigens PPD and DPT

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21

Ingwerson, Jennifer Ann. "Induction of ovulation and LH response in cyclic mares treated with gonadorelin diacetate tetrahydrate." [Ames, Iowa : Iowa State University], 2007.

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22

Pucci, Nicole Christine. "Intolerance of Uncertainty, Anxiety and Worry in Response to a Novel Induction of Uncertainty." Case Western Reserve University School of Graduate Studies / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=case1322568818.

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23

Andrews, Janice M. "The modulation of htlv-1 gene expression following induction of the cellular stress response /." The Ohio State University, 1996. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487935573771058.

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24

Ukyo, Naoya. "Costimulation through OX40 is crucial for induction of an alloreactive human T cell response." Kyoto University, 2004. http://hdl.handle.net/2433/147531.

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25

Armitage, Mark. "Cytogenetic damage, oncogenic transformation and p53 induction in human epithelial cells in response to irradiation." Thesis, University of St Andrews, 1994. http://hdl.handle.net/10023/13910.

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Ionizing radiation can have several different effects on cells, some are almost instantaneous such as the generation of DNA damage, other cellular responses take a matter of minutes or hours - DNA repair protein induction/activation, and others may take months or even years to be manifested - carcinogenesis. Human epithelial cell lines derived from both normal, non-neoplastic tissues and from a malignant source were cultured in order to examine several effects of ionizing radiation on such cell types. Cells not from a malignant source were previously immortalized by viral infection or by trans

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26

Engh, Johannes, and Malin Olofsson. "Do cognitive responses to how we feel really matter? : a psychometric evaluation and experimental extension of the Responses to Positive Affect questionnaire (RPA)." Thesis, Örebro universitet, Akademin för juridik, psykologi och socialt arbete, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-20647.

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This study aims to investigate cognitive response styles to positive affect. A Swedish version of the Responses to Positive Affect questionnaire (RPA) was psychometrically evaluated and experimentally tested as participants were mood induced. The 3-factor model for the RPA questionnaire (Self-focused positive rumination, Emotion-focused positive rumination and Dampening) was replicated, and the RPA was further explored through analyses of convergent and incremental validity. The experimental results revealed that the two positive rumination subscales had a strong relationship with each other a

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27

Mochamad, Arief Soleh. "Diversity and Mechanism of the Photosynthetic Induction Response among Various Soybean [Glycine max (L.) Merr.] Genotypes." Kyoto University, 2016. http://hdl.handle.net/2433/215607.

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Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(農学)<br>甲第19781号<br>農博第2177号<br>新制||農||1041(附属図書館)<br>学位論文||H28||N4997(農学部図書室)<br>32817<br>京都大学大学院農学研究科農学専攻<br>(主査)教授白岩立彦, 教授奥本裕, 教授稲村達也<br>学位規則第4条第1項該当

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28

Goh, Kar Mun. "Induction of defence response in lignin biosynthesis of Elaeis guineensis during an interaction with Ganoderma boninense." Thesis, University of Nottingham, 2016. http://eprints.nottingham.ac.uk/33466/.

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Oil palm is a dynamic economic crop that provides good income and is a source of dietary energy for the global population by palm oil. However, oil palm has low resistance to basal stem rot (BSR) disease caused by Ganoderma boninense. It is hypothesised that the process of cell wall lignification could serve as the first line of defence in oil palm. Lignification delays the infection progress of G. boninense. This present study evaluated the underlying molecular and biochemical lignin biosynthesis events and the quantification and deposition patterns of lignin in oil palm upon G. boninense inf

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29

He, Yongqun. "Induction of Protection, Antibodies and Cell Mediated Immune Responses by Brucella Abortus Strain RB51, Ochrobactrum Anthropi and Recombinants Thereof." Diss., Virginia Tech, 1999. http://hdl.handle.net/10919/11276.

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Although it is known that cell-mediated immunity (CMI) plays a key role in protection against brucellosis, the exact immune mechanisms leading to protection are still not fully understood. Better understanding of the mechanisms would help in the development of a human Brucella vaccine and help in improving animal vaccines. In this research, B. abortus strain RB51 and a closely-related, nonpathogenic Ochrobactrum anthropi (strain 49237) bacterium were used to study the immune response against brucellosis in mice. Both O. anthropi strain 49237 and recombinant strain 49237 expressing Brucella pro

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30

Souza, Vanz Ana Letícia de [Verfasser]. "Physiological response of Pichia pastoris to recombinant protein production under methanol induction / Ana Letícia de Souza Vanz." Hannover : Technische Informationsbibliothek und Universitätsbibliothek Hannover (TIB), 2013. http://d-nb.info/1036512533/34.

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31

Holmes, Beverly Jane. "A dual role for the CD8'+T cells in the induction and maintenance for the IgE response." Thesis, King's College London (University of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.286404.

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32

Baptiste, Quinn S. "The effects of diet and weight on induction of puberty and fertility response in yearling beef heifers." Morgantown, W. Va. : [West Virginia University Libraries], 2002. http://etd.wvu.edu/templates/showETD.cfm?recnum=2400.

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Thesis (M.S.)--West Virginia University, 2002.<br>Title from document title page. Document formatted into pages; contains vi, 63 p. : ill. (some col.). Vita. Includes abstract. Includes bibliographical references (p. 49-62).

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33

Hutsell, Blake Allen. "Mechanics of Stimulus & Response Generalization in Signal Detection & Psychophysics: Adaptation of Static Theory to Dynamic Performance." OpenSIUC, 2009. https://opensiuc.lib.siu.edu/dissertations/98.

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The area of perceptual decision-making research seeks to understand how our perception of the world affects our judgment. Laboratory investigations of perceptual decision-making concentrate on observers' ability to discriminate among stimuli and their biases towards reporting one stimulus more frequently than others. Choice theories assume that these performance measures are determined by generalization of reinforcement along both stimulus and response dimensions. Historically the majority of research has addressed situations in which the difference among stimuli and resulting consequences of

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34

Busse, Matthew Schmidt. "Transcriptional regulation of antimicrobial peptide induction by NF-[kappa]B family members during the Drosophila melanogaster immune response." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2007. http://wwwlib.umi.com/cr/ucsd/fullcit?p3243870.

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Thesis (Ph. D.)--University of California, San Diego, 2007.<br>Title from first page of PDF file (viewed February 12, 2007). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references (p. 85-93).

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35

Tujulin, Eva. "Host interactions of the intracellular bacterium Coxiella burnetii : internalisation, induction of bacterial proteins and host response upon infection /." Uppsala : Swedish Univ. of Agricultural Sciences (Sveriges lantbruksuniv.), 1999. http://epsilon.slu.se/avh/1999/91-576-5425-5.pdf.

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36

Roth, Gustavo [Verfasser]. "The unfolded protein response pre and post methanol induction of Komagataella (Pichia) pastoris producing secretory insulin precursor / Gustavo Roth." Hannover : Technische Informationsbibliothek und Universitätsbibliothek Hannover (TIB), 2015. http://d-nb.info/1078747725/34.

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37

Sorge, Sebastian [Verfasser], and Ingrid [Akademischer Betreuer] Lohmann. "A mitochondrial PERK mediates mitonuclear communication through induction of an ATF4-dependent transcriptional response / Sebastian Sorge ; Betreuer: Ingrid Lohmann." Heidelberg : Universitätsbibliothek Heidelberg, 2018. http://d-nb.info/1197802304/34.

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38

Al-Asadi, Mazin Gh. "Investigation of dormancy in acute myeloid leukaemia cells and the induction of dormancy in their response to genotoxic stress." Thesis, University of Nottingham, 2017. http://eprints.nottingham.ac.uk/43320/.

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Cancer cells can exist in a reversible state of dormancy (G0 phase of the cell cycle). Relapse of acute myeloid leukaemia (AML) is likely due to dormant cells escape frontline treatment. Dormant AML cells have been identified in the bone marrow (BM) endosteal region which is characterised by an excess of TGFβ1 and a shortage of nutrients. As the first step in this project, we developed an in vitro model of AML cell dormancy by exploiting these features. Following a preliminary investigation of four AML cell lines, the CD34+CD38- line TF1-a was selected for in-depth investigation. TF1-a showed

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39

Nothelfer, Katharina. "Manipulation of the adaptive immune response by Shigella : Induction of B cell apoptosis dependent on the IpaD virulence factor." Paris 7, 2012. http://www.theses.fr/2012PA077159.

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Shigella, une bactérie à Gram-négatif, est l'agent responsable de la dysentrie bacillaire, une rectocolite aigüe caractérisée par l'invasion de la muqueuse colo-rectale et l'induction d'une inflammation aigüe accompagnée d'une destruction tissulaire massive. L'immunité naturelle, de courte durée, est médiée par des anticorps et requiert plusieurs infections pour être initiée. L'objectif de ce travail était d'analyser si le ciblage direct des lymphocytes par Shigella pouvait avoir un impact sur l'induction de la réponse spécifique. Nous rapportons ici que Shigella cible les lymphocytes B requis

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40

Chiu, Helen Hoi-Lun. "Induction of neuronal apoptosis inhibitory protein expression in response to androgen deprivation by NF-κB in prostate cancer cells". Thesis, University of British Columbia, 2007. http://hdl.handle.net/2429/31584.

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Androgen deprivation therapy is an efficacious treatment for advanced prostate cancer (CaP) by inducing apoptosis of prostate cells. Despite the initial effectiveness of this systemic therapy, the cancer will inevitably recur and progress to an androgen-independent stage. The molecular mechanism by which some CaP cells may bypass the cell death induced by androgen deprivation is unclear. Emerging studies have highlighted the role of the inhibitor of apoptosis protein (lAP) family members in conferring an enhanced ability of malignant cells to survive in conditions normally resulting in cell de

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41

MacLaren, Ann Prentice. "Disruption of the 26S proteasome degradation pathway in mammary epithelial cells results in the induction of an apoptotic response." Thesis, University of Edinburgh, 1999. http://hdl.handle.net/1842/15246.

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TBP1 expression increased around day 10 gestation in the mammary gland. Analysis of protein levels confirmed that the increase in TBP1 expression observed was due to an overall increase in 26S proteasome. The increase in TBP1 expression observed by differential display was at the stage when the mammary gland begins to respond to lactogenic hormone by differentiating and expressing the milk protein β casein. Studies in mammary epithelial cells (MEC) revealed the increase in the proteasome level was not lactogenic hormone dependent as the expression profile from the display results implied. We f

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42

Alhoufie, S. T. S. "Induction of the stringent response in Staphylococcus aureus by mupirocin and its effect on global transcription and virulence factors." Thesis, University of Salford, 2014. http://usir.salford.ac.uk/32933/.

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Staphylococcus aureus is a major pathogen in both hospital and community settings and it causes infections ranging from mild skin and wound infections to life-threatening systemic illness and, together with the emergence of antibiotic resistance, has been a major cause of morbidity and mortality worldwide. The stringent response, is a stress response that bacteria display to avoid death when subjected to amino-acid starvation. This phenomenon has been observed in different species among Gram positive and Gram negative bacteria but relatively few studies have observed the stress response in Sta

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43

Bartolo, Laurent. "Réponses immunitaires et induction de tolérance pour la thérapie génique rAAV du muscle basée sur le ciblage des hépatocytes : induction de tolérance et mécanismes immunitaires liés à la transduction des hépatocytes Liver-based tolerance induction of CD8+ and CD4+ T cells responses in rAAV muscle gene therapy." Thesis, Sorbonne Paris Cité, 2018. http://www.theses.fr/2018USPCB198.

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Les réponses immunes contre les traitements de thérapie génique rAAV, dirigées non seulement contre la capside du vecteur, mais aussi contre le transgène, représentent un défi majeur en particulier dans le contexte d'un transfert de gènes vers le muscle pour le traitement de diverses maladies monogéniques du muscle. Cette thèse est focalisée sur la réponse dirigée contre le transgène. Celle-ci se met en place contre des éléments du transgène thérapeutique qui ne sont pas initialement présents, ou insuffisamment exprimés, chez l'hôte et peut entraîner l'élimination des cellules qui produisent l

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44

Nanda, Arun Michael [Verfasser], and Julia [Akademischer Betreuer] Frunzke. "Relationship between the SOS Response and Spontaneous Induction of Prophage CGP3 in Corynebacterium glutamicum / Arun Michael Nanda. Betreuer: Julia Frunzke." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2016. http://d-nb.info/1102352527/34.

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45

Ramadan, Gamal Ramadan Shebl. "Induction of in vitro T cell immune response against the variable region of paraprotein light chain through autologous dendritic cells." [S.l.] : [s.n.], 2001. http://deposit.ddb.de/cgi-bin/dokserv?idn=963906038.

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46

Bourges, Anaïs. "Molecular mechanisms of the pressure-activation of Mrr, a Type IV restriction endonuclease, and induction of SOS response in Escherichia coli." Thesis, Montpellier, 2018. http://www.theses.fr/2018MONTT051/document.

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La pression rencontrée par les organismes sur Terre varie de la pression atmosphérique à 110 MPa atteinte dans la fosse la plus profonde de l'océan. Même si Escherichia. coli n’est pas naturellement résistante à la pression, elle capable d'acquérir une résistance et même supporter un choc de pression de 2 GPa (~20 000 atm). L'une des réponses intéressantes d’E. coli à un choc sous létal de pression (100 MPa) est l'induction d'une réponse SOS dépendante de RecA due à des lésions double brins de l’ADN. La pression elle-même n'est pas capable de compromettre l'intégrité covalente de l'ADN. Des cr

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47

Ngan, Tiffany. "Evaluation of the Response of Armor Alloys to High Temperature Deformation." The Ohio State University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=osu1387303092.

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48

Morrison, Andrew John. "Heat shock transcription factors and the hsp70 induction response in neural and non-neural tissues of the hyperthermic rat during postnatal development." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0028/MQ50480.pdf.

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49

Zhang, Yu-Qian. "INDUCTION OF THE HEAT SHOCK RESPONSE TO PROTECT AGAINST POLYGLUTAMINE DISEASES AND THE ROLE OF PROTEIN SUMOYLATION IN LAMINOPATHIES AND ALZHEIMER'S DISEASE." UKnowledge, 2008. http://uknowledge.uky.edu/gradschool_diss/632.

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Heat shock proteins function as molecular chaperones which help protein folding and prevent protein aggregation. My study shows that celastrol, a pharmacological compound capable of up-regulating the levels of heat shock proteins, inhibits cell death and protein aggregation caused by expanded polyglutamine containing protein, and the protective effects of celastrol are dependent on heat shock factor 1. These results suggest the potential of celastrol as a therapeutic agent in the treatment of polyglutamine diseases. Sumoylation is a protein modification which plays diverse roles in regulating

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Carpentier, Maxime. "Modulation des voies de présentation antigénique et induction de lymphocytes T régulateurs pour la thérapie génique." Thesis, Paris 5, 2013. http://www.theses.fr/2013PA05T081.

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Abstract:

L’expression d’un transgène grâce au vecteur AAV offre une perspective thérapeutique très prometteuse dans le traitement de maladies monogéniques. Malheureusement, il apparait souvent que des réponses immunes contre le vecteur et le transgène conduisent à un rejet des cellules transduites ainsi qu’à la mise en place d’une mémoire immunitaire spécifique empêchant un nouveau traitement ultérieur. Avec la perspective d’éviter tout rejet immun des cellules transduites, j’ai développé deux approches distinctes. D’une part, nous avons développé un système dans lequel l’expression du transgène est dé

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