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Journal articles on the topic 'Responses against Stress and Chronic Infections'

Author: Grafiati
Published: 3 June 2025
Last updated: 31 July 2025

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1

Meng, Di, Yanxin Hu, Chong Xiao, Tangting Wei, Qiang Zou, and Ming Wang. "Chronic Heat Stress Inhibits Immune Responses to H5N1 Vaccination through Regulating CD4+CD25+Foxp3+Tregs." BioMed Research International 2013 (2013): 1–11. http://dx.doi.org/10.1155/2013/160859.

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Chronic heat stress (CHS) is known to have negative impacts on the immune responses in animals and increases their susceptibility to infections including the highly pathogenic avian influenza virus H5N1. However, the role of regulatory T cells (Tregs) in CHS immunosuppression remains largely undefined. In this study, we demonstrated a novel mechanism by which CHS suppressed both Th1 and Th2 immune responses and dramatically decreased the protective efficacy of the formalin-inactivated H5N1 vaccine against H5N1 influenza virus infection. This suppression was found to be associated with the indu
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2

BELDOMENICO, Pablo M., and Mike BEGON. "Stress-host-parasite interactions: a vicious triangle?" FAVE Sección Ciencias Veterinarias 14, no. 1/2 (2016): 6–19. http://dx.doi.org/10.14409/favecv.v14i1/2.5160.

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The potential for synergy between host physiological condition and infection has recently been recognised. Here we review the evidence to support the idea that stress may play a key role in the interplay between host and parasite, integrating a three-way circular synergistic interaction between stressors, infections and host response: chronic stress can elicit responses that impoverish the host’s physiological condition (including its immune function), which predisposes to infection, which results in more stress, and so on. We argue that this introduces additional explanatory power to previous
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3

Shohreh Ghasemi, Poorya Davoodi, Fargol Mashhadi Akbar Boojar, and Mahmood Dashti. "Efficacy of utilizing cannabidiol in reduction of inflammation and autoimmunity manifestation." Open Access Research Journal of Biology and Pharmacy 4, no. 1 (2022): 040–47. http://dx.doi.org/10.53022/oarjbp.2022.4.1.0020.

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This article reviews recent research on cannabinoids that mediate anti-inflammatory effects through cannabinoid receptors. Inflammation is involved in many of the diseases. Chronic inflammation can be caused by cancer, autoimmune disorders, and untreated infections. Some factors like smoking, obesity, or stress may also be caused by chronic inflammation. Early researchers show that Cannabidiol (CBD) has a significant role in reducing inflammation. Cannabis sativa is most commonly used for its medicinal and anti-inflammatory properties. This article focuses primarily on using cannabinoids as a
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4

Ferraz, Maria Pia. "The Potential of Cannabidiol in the Management of Oral Infections." Applied Sciences 15, no. 10 (2025): 5736. https://doi.org/10.3390/app15105736.

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Oral infections, caused by bacterial, fungal, and viral pathogens, are a significant source of dental morbidity and can lead to systemic complications, especially in immunocompromised individuals. Complex microbial interactions and host immune responses drive common conditions such as dental caries, periodontal disease, oral candidiasis, and herpetic lesions. Conventional antimicrobial therapies face limitations due to resistance and adverse effects, prompting interest in alternative treatments. Cannabidiol (CBD), a non-psychoactive compound derived from Cannabis sativa, has emerged as a promi
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Shimba, Akihiro, and Koichi Ikuta. "Immune-enhancing effects of glucocorticoids in response to day–night cycles and stress." International Immunology 32, no. 11 (2020): 703–8. http://dx.doi.org/10.1093/intimm/dxaa048.

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Abstract Environmental cues such as the day–night cycle or stressors trigger the production of glucocorticoids (GCs) by the adrenal cortex. GCs are well known for their anti-inflammatory effects that suppress the production of inflammatory cytokines and induce the apoptosis of lymphocytes. Recent studies in mice, however, have revealed pro-inflammatory effects. The diurnal oscillation of GCs induces the expression of IL-7 receptor α (IL-7Rα) and C–X–C motif chemokine receptor 4 (CXCR4) at the active phase, which drives the diurnal homing of T cells into lymphoid organs. This accumulation of T
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6

Aasini Maria Georgina and Preetha Devi N B. "A review on immunity through stress reduction and positive mindset." World Journal of Advanced Research and Reviews 25, no. 3 (2025): 026–31. https://doi.org/10.30574/wjarr.2025.25.3.0652.

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The intricate network of cells and processes that makes up the immune system is a vital first line of defense against dangerous infections. This review explores the complex relationships that exist between immunity, stress, and psychological resilience, emphasizing the role that stress management and an optimistic outlook have in influencing immune function. An adaptable collection of mental and affective functions known as the Behavioral Immune System (BIS) aids in avoiding possible infection sources. Acute stress can momentarily stimulate immune function, but chronic stress results in immuno
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7

Fantini, Cristina, Clarissa Corinaldesi, Andrea Lenzi, Silvia Migliaccio, and Clara Crescioli. "Vitamin D as a Shield against Aging." International Journal of Molecular Sciences 24, no. 5 (2023): 4546. http://dx.doi.org/10.3390/ijms24054546.

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Aging can be seen as a physiological progression of biomolecular damage and the accumulation of defective cellular components, which trigger and amplify the process, toward whole-body function weakening. Senescence initiates at the cellular level and consists in an inability to maintain homeostasis, characterized by the overexpression/aberrant expression of inflammatory/immune/stress responses. Aging is associated with significant modifications in immune system cells, toward a decline in immunosurveillance, which, in turn, leads to chronic elevation of inflammation/oxidative stress, increasing
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8

Shimba, Akihiro, and Koichi Ikuta. "Immune-enhancing effects of glucocorticoids in response to day–night cycles and stress." International Immunology 32, no. 11 (2020): 703–8. https://doi.org/10.5281/zenodo.13535018.

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(Uploaded by Plazi for the Bat Literature Project) Environmental cues such as the day–night cycle or stressors trigger the production of glucocorticoids (GCs) by the adrenal cortex. GCs are well known for their anti-inflammatory effects that suppress the production of inflammatory cytokines and induce the apoptosis of lymphocytes. Recent studies in mice, however, have revealed pro-inflammatory effects. The diurnal oscillation of GCs induces the expression of IL-7 receptor α (IL-7Rα) and C–X–C motif chemokine receptor 4 (CXCR4) at the active phase, which drives the diurnal homing of T cells int
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9

Shimba, Akihiro, and Koichi Ikuta. "Immune-enhancing effects of glucocorticoids in response to day–night cycles and stress." International Immunology 32, no. 11 (2020): 703–8. https://doi.org/10.5281/zenodo.13535018.

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(Uploaded by Plazi for the Bat Literature Project) Environmental cues such as the day–night cycle or stressors trigger the production of glucocorticoids (GCs) by the adrenal cortex. GCs are well known for their anti-inflammatory effects that suppress the production of inflammatory cytokines and induce the apoptosis of lymphocytes. Recent studies in mice, however, have revealed pro-inflammatory effects. The diurnal oscillation of GCs induces the expression of IL-7 receptor α (IL-7Rα) and C–X–C motif chemokine receptor 4 (CXCR4) at the active phase, which drives the diurnal homing of T cells int
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10

Poroshinska, О., S. Shmayun, M. Nischemenko, L. Stovbetska, A. Emelyanenko, and V. Koziy. "Influence of stress factors on adaptive and behavioral responses in sows and piglets." Naukovij vìsnik veterinarnoï medicini, no. 2(160) (November 24, 2020): 110–21. http://dx.doi.org/10.33245/2310-4902-2020-160-2-110-121.

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The article presents data from the scientific literature describing the influence of stress factors on pigs in modern production conditions. It was established that stress factors that affect sows during gestation period affect fetal development and are important determinants of behavioral disorders in piglets in the future. Conditions for keeping and feeding pregnant sows play an important role in ensuring the behavior of future offspring. Stress of sows in the late stages of gestation can cause a negative longterm effect on the functioning of the immune system of piglets. This reduces the ab
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11

Farrant, Katie V., Livia Spiga, Jane C. Davies, and Huw D. Williams. "Response of Pseudomonas aeruginosa to the Innate Immune System-Derived Oxidants Hypochlorous Acid and Hypothiocyanous Acid." Journal of Bacteriology 203, no. 2 (2020): e00300-20. http://dx.doi.org/10.1128/jb.00300-20.

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ABSTRACTPseudomonas aeruginosa is a significant nosocomial pathogen and is associated with lung infections in cystic fibrosis (CF). Once established, P. aeruginosa infections persist and are rarely eradicated despite host immune cells producing antimicrobial oxidants, including hypochlorous acid (HOCl) and hypothiocyanous acid (HOSCN). There is limited knowledge as to how P. aeruginosa senses, responds to, and protects itself against HOCl and HOSCN and the contribution of such responses to its success as a CF pathogen. To investigate the P. aeruginosa response to these oxidants, we screened 70
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12

Amer, Johnny, and Eitan Fibach. "Chronic Oxidative Stress Reduces the Oxidative Burst Response of Thalassemic Polymorphonuclear Neutrophils." Blood 104, no. 11 (2004): 3811. http://dx.doi.org/10.1182/blood.v104.11.3811.3811.

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Abstract Bacterial infections are a serious complication in the beta-thalassemia syndrome, but the mechanisms underlying the increased susceptibility to these infections are not fully understood. Factors, likely to be involved are anemia, splenectomy, iron-overload, alterations in immune responses and defective phagocytic cells. Polymorphonuclear neutrophils (PMN) destroy microbial organisms by a burst of reactive oxygen species (ROS) in response to bacterial components as well as to phorbol myristate acetate (PMA). The respiratory burst is mediated by a multi-component enzyme - NADPH oxidase.
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13

Korea, C. "Searching the next remedies within the bacterial arsenal." ACTA MICROBIOLOGICA HELLENICA 61, no. 3 (2016): 175–89. https://doi.org/10.5281/zenodo.10021168.

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Biofilms are bacterial communities, often multi-species, attached on abiotic or biotic surfaces and enclosed in an extracellular matrix. The matrix is composed of extracellular polymeric substances (EPS) such as proteins, polysaccharides and bacterial DNA. Biofilm formation occurs in four steps: first contact, attachment, maturation, and dispersion. After initial adhesion, if the environmental conditions are favorable, this reversible adhesion can lead to irreversible attachment and extracellular matrix production, thus to micro-colony formation and biofilm maturation. Several bacterial adhesi
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14

Chippalkatti, Rohan, Kirti Badave, Ayesha Alim Khan, and Sandhya Rane. "Anti-quorum Sensing, Oxidative Stress and Anti-Biofilm Inducing Abilities of Vitamin K3 Analogues Against Chronic Respiratory Infection of Mucoid Variants Pseudomonas aeruginosa Strain PAO1." International Journal of Current Microbiology and Applied Sciences 13, no. 7 (2024): 74–85. http://dx.doi.org/10.20546/ijcmas.2024.1307.009.

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Almost all antibiotics target either bacterial function or biofilms but do not consider the damage due to host responses, thus, even if the bacteria are eliminated, the tissue damage cannot be prevented. The mucoid phenotype and oxidative stress severely limit the efficacy of current therapeutics for chronic respiratory infections (CRI) of Pseudomonas aeruginosa in cystic fibrosis (CF) patients. In the present study, we examined the activity of a novel set of VitaminK3 derivatives on biofilms of the mucoid variants of P.aeruginosa. Acyl-homoserine lactones (AHLs) an important signaling molecul
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15

Stamova, Sylvia, Neli Ermenlieva, Gabriela Tsankova, Silviya P. Nikolova, and Emilia Georgieva. "Synergistic Antimicrobial Activity of Essential Oils and Vitamin C: Mechanisms, Molecular Targets and Therapeutic Potential." Applied Sciences 15, no. 8 (2025): 4294. https://doi.org/10.3390/app15084294.

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Antimicrobial resistance (AMR) poses an increasing challenge to modern medicine, necessitating the search for novel therapeutic strategies. This study evaluates the synergistic antimicrobial activity of oregano essential oil (OEO) and thyme essential oil (TEO) in combination with vitamin C against clinically relevant pathogens. The antimicrobial activity was assessed using MIC, MBC and MFC assays, alongside in silico analyses utilizing Swiss Target Prediction, STRING and Reactome to identify potential molecular targets and underlying biological mechanisms. The results demonstrate that the comb
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16

Griffin, John Lawrence, Mahendra Kumar Trivedi, Alice Branton, Dahryn Trivedi, and Gopal Nayak. "Effect of the Energy of Consciousness (The Trivedi Effect®) on Physicochemical, Thermal, Structural, and Behavioral Properties of Magnesium Gluconate." Chemical and Biomolecular Engineering 2, no. 2 (2017): 113–23. https://doi.org/10.5281/zenodo.884138.

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Magnesium gluconate is an organometallic pharmaceutical compound used for the prevention and treatment of hypomagnesemia. The objective of the current research work was to examine the influence of The Trivedi Effect®-Energy of Consciousness Healing Treatment (Biofield Energy Treatment) on magnesium gluconate for the alteration in the physicochemical, structural, thermal and behavioral properties using PXRD, PSD, FT-IR, UV-vis spectroscopy, TGA, and DSC analysis. Magnesium gluconate was divided into two parts – one part was control without any Biofield Energy Treatment, while another part was t
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17

Abdullah, Mahmud-Al-Rafat, and W. Taylor-Robinson Andrew. "Emergence and Persistence of Hantavirus in Rodent Reservoirs: Role of Glucocorticoid Hormone." Biohelikon 2 (January 1, 2014): 1–5. https://doi.org/10.5281/zenodo.816336.

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Rodent-borne hantaviruses have received considerable attention in recent years due to the high mortality rate in humans that their infections cause. Anthropogenic stressors are key factors in the emergence of hantavirus-associated diseases. Urbanization, deforestation, noise pollution, artificial lighting and electromagnetic fields are the most common forms of human impact on the environment. An increased systemic concentration of the immunosuppressive class of steroid hormone glucocorticoid is a frequent consequence of chronic anthropogenic stress. Elevated glucocorticoid levels play a crucia
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18

Liu, Shiqi, Stanley Brul, and Sebastian A. J. Zaat. "Isolation of Persister Cells of Bacillus subtilis and Determination of Their Susceptibility to Antimicrobial Peptides." International Journal of Molecular Sciences 22, no. 18 (2021): 10059. http://dx.doi.org/10.3390/ijms221810059.

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Persister cells are growth-arrested subpopulations that can survive possible fatal environments and revert to wild types after stress removal. Clinically, persistent pathogens play a key role in antibiotic therapy failure, as well as chronic, recurrent, and antibiotic-resilient infections. In general, molecular and physiological research on persister cells formation and compounds against persister cells are much desired. In this study, we firstly demonstrated that the spore forming Gram-positive model organism Bacillus subtilis can be used to generate persister cells during exposure to antimic
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Frippiat, Thibault, Tatiana Art, and Catherine Delguste. "Silver Nanoparticles as Antimicrobial Agents in Veterinary Medicine: Current Applications and Future Perspectives." Nanomaterials 15, no. 3 (2025): 202. https://doi.org/10.3390/nano15030202.

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Silver nanoparticles (AgNPs) have gained significant attention in veterinary medicine due to their antimicrobial properties and potential therapeutic applications. Silver has long been recognized for its ability to combat a wide range of pathogens, and when engineered at the nanoscale, silver’s surface area and reactivity are greatly enhanced, making it highly effective against bacteria, viruses, and fungi. This narrative review aimed to summarize the evidence on the antimicrobial properties of AgNPs and their current and potential clinical applications in veterinary medicine. The antimicrobia
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20

Mitrova Telenta, Julija, Maja Dimova, Ivana Dohceva Karajovanov, Viktor Simeonovski, and Biljana Ahtarova. "THE WAR UNDER THE SKIN - BIOFILM AND INFLAMMATION IN CHRONIC WOUNDS." Academic Medical Journal 5, no. 1 (2025): 81–88. https://doi.org/10.53582/amj255181mt.

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The skin, the largest organ in the body, protects against external stimuli and microorganisms. A balanced skin microbiota, including both commensal and pathogenic microorganisms, is essential for skin health. Disruptions in this balance can lead to infections and inflammation, which are key factors in delayed wound healing. Biofilm formation further complicates the process. In chronic wounds, healing is often impaired during the inflammatory phase due to persistent activation of the immune response. This leads to increased immune cell activation, along with heightened activity of matrix metall
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Smirnova, Olga Valentinovna, Alexander Alexandrovich Sinyakov, and Eduard Vilyamovich Kasparov. "The Role of Immunoglobulin G (IgG), IgA and IgE—Antibodies against Helicobacter pylori in the Development of Oxidative Stress in Patients with Chronic Gastritis." Biomedicines 10, no. 8 (2022): 2053. http://dx.doi.org/10.3390/biomedicines10082053.

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Aim: To study the predominant serum responses (antibodies IgG, IgA, IgE) against H. pylori in relation to the indicators of the system “lipid peroxidation–antioxidant system” in various pathogenetic variants of chronic gastritis (CG). Materials and Methods: Sixty patients with CG, 33 patients with chronic atrophic gastritis (CAG) and 31 patients with chronic allergic gastritis (CALG) were examined. The values of the system of lipid peroxidation and antioxidant protection in plasma were determined in the serum of patients using a spectrophotometric method. Statistical data processing was carrie
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Arshad Ullah, Muhammad. "Cat’s Claw Nutrients for Medical Treatments." Nutrition and Food Processing 6, no. 7 (2023): 01–07. http://dx.doi.org/10.31579/2637-8914/163.

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Uncaria tomentosa (Willd. ex Schult.) DC is commonly known as cat’s claw that is derived from the Spanish word Uña de Gato that identifies the small, curved-back thorns on the stem at the leaf junction. It is a tropical medicinal vine of the Rubiaceae family that is widely distributed in the Amazon rainforest and other areas of South and Central America. Cat's claw, which is scientifically known as Uncaria tomentosa, has been historically used to treat and prevent inflammatory disorders, particularly osteoarthritis. Traditionally, it has been used to treat chronic viral infections, bacterial i
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Procyk, Katarzyna J., Maria Rita Rippo, Roberto Testi, Fred Hoffmann, Peter J. Parker, and Manuela Baccarini. "Distinct Mechanisms Target Stress and Extracellular Signal-Activated Kinase 1 and Jun N-Terminal Kinase During Infection of Macrophages with Salmonella." Journal of Immunology 163, no. 9 (1999): 4924–30. http://dx.doi.org/10.4049/jimmunol.163.9.4924.

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Abstract The interaction between bacteria and macrophages is central to the outcome of Salmonella infections. Salmonella can escape killing by these phagocytes and survive and multiply within them, giving rise to chronic infections. Cytokines produced by infected macrophages are involved in the early gastrointestinal pathology of the infection as well as in the induction and maintenance of the immune response against the invaders. Jun N-terminal kinases (JNK) are activated by inflammatory stimuli and play a role in cytokine production. We have investigated the signaling routes leading to JNK a
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Martini, Anthony M., Sara A. Alexander, and Anupama Khare. "Mutations in the Staphylococcus aureus Global Regulator CodY confer tolerance to an interspecies redox-active antimicrobial." PLOS Genetics 21, no. 3 (2025): e1011610. https://doi.org/10.1371/journal.pgen.1011610.

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Bacteria often exist in multispecies communities where interactions among different species can modify individual fitness and behavior. Although many competitive interactions have been described, molecular adaptations that can counter this antagonism and preserve or increase fitness remain underexplored. Here, we characterize the adaptation of Staphylococcus aureus to pyocyanin, a redox-active interspecies antimicrobial produced by Pseudomonas aeruginosa, a co-infecting pathogen frequently isolated from wound and chronic lung infections with S. aureus. Using experimental evolution, we identifi
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Reber, Stefan O., Philip H. Siebler, Nina C. Donner, et al. "Immunization with a heat-killed preparation of the environmental bacteriumMycobacterium vaccaepromotes stress resilience in mice." Proceedings of the National Academy of Sciences 113, no. 22 (2016): E3130—E3139. http://dx.doi.org/10.1073/pnas.1600324113.

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The prevalence of inflammatory diseases is increasing in modern urban societies. Inflammation increases risk of stress-related pathology; consequently, immunoregulatory or antiinflammatory approaches may protect against negative stress-related outcomes. We show that stress disrupts the homeostatic relationship between the microbiota and the host, resulting in exaggerated inflammation. Repeated immunization with a heat-killed preparation ofMycobacterium vaccae, an immunoregulatory environmental microorganism, reduced subordinate, flight, and avoiding behavioral responses to a dominant aggressor
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Ninkov, Marina, Patrick Thomas Rudak, Nicole Ilayda Wang, Rasheduzzaman Rashu, Wataru Inoue, and S. M. Mansour Haeryfar. "Psychological stress triggers the accumulation of myeloid-derived suppressor cells in the liver through adrenergic receptor signaling." Journal of Immunology 210, no. 1_Supplement (2023): 167.13. http://dx.doi.org/10.4049/jimmunol.210.supp.167.13.

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Abstract Chronic physiological stress affects tightly regulated crosstalk between the nervous and the immune system. However, the exact mechanism(s) of stress-induced immunomodulation is far from clear. Immature myeloid cells such as myeloid-derived suppressor cells (MDSCs) impair immune responses, which may in turn increase susceptibility to infections and cancer or their complications. In a mouse model of chronic psychological stress through physical restraint, we found mononuclear-MDSC (Mo-MDSC) cells, defined as CD11b +Ly6C highLy6G highcells, to accumulate in the liver. These cells expres
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Arimilli, Subhashini, Brad Damratoski, and G. L. Prasad. "Role of oxidative stress in the suppression of immune responses in peripheral blood mononuclear cells exposed to combustible tobacco product preparations." Journal of Immunology 196, no. 1_Supplement (2016): 197.12. http://dx.doi.org/10.4049/jimmunol.196.supp.197.12.

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Abstract Cigarette smoking is a major risk factor for several human diseases. Chronic inflammation, resulting from increased oxidative stress, has been suggested as a mechanism that contributes to the increased susceptibility of smokers to cancer and microbial infections. We have previously shown that whole smoke-conditioned medium (WS-CM) and total particulate matter (TPM) prepared from Kentucky 3R4F reference cigarettes potently suppressed agonist-stimulated cytokine secretion and target cell killing in peripheral blood mononuclear cells (PBMCs) under ex vivo conditions. Here, we sought to i
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Schnitzer, Debra Jane, Mahendra Kumar Trivedi, Gopal Nayak, Alice Branton, and Dahryn Trivedi. "Investigation of Physicochemical, Spectral, and Thermal Properties of Sodium Selenate Treated with the Energy of Consciousness (The Trivedi Effect®)." American Journal of Life Sciences 5, no. 1 (2017): 27–37. https://doi.org/10.5281/zenodo.835625.

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Sodium selenate is used for the prevention and treatment of various disorders like cancer, diabetes, inflammation diseases, etc. The objective of the current study was to evaluate the effect of The Trivedi Effect®-Energy of Consciousness Healing Treatment (Biofield Energy Treatment) on physicochemical, spectral, and thermal properties of The Trivedi Effect®-Biofield Energy Treated sodium selenate using various analytical methods such as PXRD, PSD, FT-IR, UV-vis spectroscopy, TGA, and DSC analysis. Sodium selenate was divided into two parts – one part was control without any treatment and anoth
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Shimba, Akihiro, and Koichi Ikuta. "Control of immunity by glucocorticoids in health and disease." Seminars in Immunopathology 42, no. 6 (2020): 669–80. https://doi.org/10.5281/zenodo.13536912.

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(Uploaded by Plazi for the Bat Literature Project) Animals receive environmental stimuli from neural signals in order to produce hormones that control immune responses. Glucocorticoids (GCs) are a group of steroid hormones produced in the adrenal cortex and well-known mediators for the nervous and immune systems. GC secretion is induced by circadian rhythm and stress, and plasma GC levels are high at the active phase of animals and under stress condition. Clinically, GCs are used for allergies, autoimmunity, and chronic inflammation, because they have strong anti-inflammatory effects and induc
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Shimba, Akihiro, and Koichi Ikuta. "Control of immunity by glucocorticoids in health and disease." Seminars in Immunopathology 42, no. 6 (2020): 669–80. https://doi.org/10.5281/zenodo.13536912.

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(Uploaded by Plazi for the Bat Literature Project) Animals receive environmental stimuli from neural signals in order to produce hormones that control immune responses. Glucocorticoids (GCs) are a group of steroid hormones produced in the adrenal cortex and well-known mediators for the nervous and immune systems. GC secretion is induced by circadian rhythm and stress, and plasma GC levels are high at the active phase of animals and under stress condition. Clinically, GCs are used for allergies, autoimmunity, and chronic inflammation, because they have strong anti-inflammatory effects and induc
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31

Hewson, Chris K., Alexander Capraro, Sharon L. Wong та ін. "Novel Antioxidant Therapy with the Immediate Precursor to Glutathione, γ-Glutamylcysteine (GGC), Ameliorates LPS-Induced Cellular Stress in In Vitro 3D-Differentiated Airway Model from Primary Cystic Fibrosis Human Bronchial Cells". Antioxidants 9, № 12 (2020): 1204. http://dx.doi.org/10.3390/antiox9121204.

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Systemic glutathione deficiency, inflammation, and oxidative stress are hallmarks of cystic fibrosis (CF), an inherited disease that causes persistent lung infections and severe damage to the respiratory system and many of the body organs. Improvements to current antioxidant therapeutic strategies are needed. The dietary supplement, γ-glutamylcysteine (GGC), which is the immediate precursor to glutathione, rapidly boosts cellular glutathione levels following a single dose in healthy individuals. Efficacy of GGC against oxidative stress induced by Pseudomonas aeruginosa, which is a common and c
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Khan, Muhammad Zahoor, Wenting Chen, Xiaotong Liu та ін. "An Overview of Bioactive Compounds’ Role in Modulating the Nrf2/Keap1/NF-κB Pathway to Alleviate Lipopolysaccharide-Induced Endometritis". International Journal of Molecular Sciences 25, № 19 (2024): 10319. http://dx.doi.org/10.3390/ijms251910319.

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Endometritis is a common inflammatory condition of the uterine endometrial lining that primarily affects perinatal dairy animals and causes significant economic losses in agriculture. It is usually triggered by pathogenic bacteria and is associated with chronic postpartum reproductive tract infections. Bacterial lipopolysaccharides (LPSs) are known to increase levels of reactive oxygen species (ROS), leading to oxidative stress and inflammation through the activation of the NF-κB signaling pathway and the inhibition of Nrf2 nuclear translocation, which regulates antioxidant response elements (
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Amen, Radwa Abdallnasser. "Therapeutic potential and characteristics of Smp43 peptide (scorpion venom) and its interaction with cellular signaling pathways: A review." Innovative Medicines & Omics 1, no. 1 (2024): 4353. http://dx.doi.org/10.36922/imo.4353.

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Smp43 peptide, derived from the venom of the scorpion Scorpio Maurus Palmatus, exhibits significant potential across a range of therapeutic domains due to its diverse biological actions. Interestingly, Smp43 possesses robust anti-inflammatory and antioxidant properties, enabling it to scavenge free radicals and suppress pro-inflammatory cytokines. This dual functionality makes Smp43 a viable candidate for the treatment of conditions associated with oxidative stress and chronic inflammation. Furthermore, its broad-spectrum antibacterial activity is indicative of its efficacy against both Gram-p
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Akhbari, Pouria, Sarah J. Richardson, and Noel G. Morgan. "Type 1 Diabetes: Interferons and the Aftermath of Pancreatic Beta-Cell Enteroviral Infection." Microorganisms 8, no. 9 (2020): 1419. http://dx.doi.org/10.3390/microorganisms8091419.

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Enteroviruses (EVs) have long been implicated in the pathogenesis of type 1 diabetes (T1D), and accumulating evidence has associated virus-induced autoimmunity with the loss of pancreatic beta cells in T1D. Inflammatory cytokines including interferons (IFN) form a primary line of defence against viral infections, and their chronic elevation is a hallmark feature of many autoimmune diseases. IFNs play a key role in activating and regulating innate and adaptive immune responses, and to do so they modulate the expression of networks of genes and transcription factors known generically as IFN stim
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Hornung, Matthew Charles, Mahendra Kumar Trivedi, Gopal Nayak, Alice Branton, and Dahryn Trivedi. "LC-MS, GC-MS, and NMR Spectroscopic Analysis of Withania somnifera (Ashwagandha) Root Extract After Treatment with the Energy of Consciousness (The Trivedi Effect®)." European Journal of Biophysics 5, no. 2 (2017): 27–37. https://doi.org/10.5281/zenodo.844961.

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Withania somnifera (Ashwagandha) root extract is very popular ancient herbal medicine. The current study was designed to investigate the impact of The Trivedi Effect® - Energy of Consciousness Healing Treatment on the structural characterization of the ashwagandha root extract using LC-MS, GC-MS, and NMR spectroscopy. Ashwagandha root extract was divided into two parts – one part was control, without any Biofield Energy Healing Treatment, while another part was treated with the Biofield Energy Healing Treatment remotely by eighteen renowned Biofield Energy Healers and defined as the Biofield E
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36

Núñez, María J., Silvia Novío, Juan Antonio Suárez, José Balboa, and Manuel Freire-Garabal. "Effects of Psychological Stress and Fluoxetine on Development of Oral Candidiasis in Rats." Clinical and Vaccine Immunology 17, no. 4 (2010): 668–73. http://dx.doi.org/10.1128/cvi.00380-09.

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ABSTRACT Psychological stress has been found to suppress cell-mediated immune responses that are important for limiting the proliferation of Candida albicans. Fluoxetine has been observed to reduce negative consequences of stress on the immune system in experimental and clinical models, but there are no data on its effects on oral candidiasis. We designed experiments to evaluate the effects of fluoxetine on the development of oral candidiasis in Sprague-Dawley rats exposed to a chronic auditory stressor. Animals were submitted to surgical hyposalivation in order to facilitate the establishment
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37

Sepahvand, Asghar, Hossein Eliasy, Mehdi Mohammadi, et al. "A review of the most effective medicinal plants for dermatophytosis in traditional medicine." Biomedical Research and Therapy 5, no. 6 (2018): 2378–88. http://dx.doi.org/10.15419/bmrat.v5i6.450.

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Fungi can evade the immune system via different processes, including recombination, mitosis, and expression of genes involved in oxidative stress responses. These processes can lead to chronic fungal diseases. Despite the growth of health care facilities, the incidence rate of fungal infections is still considerably high. Dermatophytes represent the main cause of cutaneous diseases. Dermatophytes attack keratinized tissues, such as nail, hair, and stratum corneum, due of their gravitation towards keratin, which leads to dermatophytosis. Medicinal plants have long been used to treat different d
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38

Thanasi, Rudina, Mahendra Kumar Trivedi, Gopal Nayak, Alice Branton, and Dahryn Trivedi. "LC-MS, GC-MS, and NMR Spectroscopic Analysis of Withania somnifera (Ashwagandha) Root Extract After Treatment with the Energy of Consciousness (The Trivedi Effect®)." European Journal of Biophysics 5, no. 2 (2017): 27–37. https://doi.org/10.5281/zenodo.836949.

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Withania somnifera (Ashwagandha) root extract is very popular ancient herbal medicine. The current study was designed to investigate the impact of The Trivedi Effect® - Energy of Consciousness Healing Treatment on the structural characterization of the ashwagandha root extract using LC-MS, GC-MS, and NMR spectroscopy. Ashwagandha root extract was divided into two parts – one part was control, without any Biofield Energy Healing Treatment, while another part was treated with the Biofield Energy Healing Treatment remotely by eighteen renowned Biofield Energy Healers and defined as the Biofield E
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39

Xu, Meng, Peter P. Liu, and Hongliang Li. "Innate Immune Signaling and Its Role in Metabolic and Cardiovascular Diseases." Physiological Reviews 99, no. 1 (2019): 893–948. http://dx.doi.org/10.1152/physrev.00065.2017.

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The innate immune system is an evolutionarily conserved system that senses and defends against infection and irritation. Innate immune signaling is a complex cascade that quickly recognizes infectious threats through multiple germline-encoded cell surface or cytoplasmic receptors and transmits signals for the deployment of proper countermeasures through adaptors, kinases, and transcription factors, resulting in the production of cytokines. As the first response of the innate immune system to pathogenic signals, inflammatory responses must be rapid and specific to establish a physical barrier a
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Hornung, Matthew Charles, Mahendra Kumar Trivedi, Gopal Nayak, Alice Branton, and Dahryn Trivedi. "Investigation of Physicochemical, Spectral, and Thermal Properties of Sodium Selenate Treated with the Energy of Consciousness (The Trivedi Effect®)." American Journal of Life Sciences 5, no. 1 (2017): 27–37. https://doi.org/10.5281/zenodo.844584.

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Sodium selenate is used for the prevention and treatment of various disorders like cancer, diabetes, inflammation diseases, etc. The objective of the current study was to evaluate the effect of The Trivedi Effect®-Energy of Consciousness Healing Treatment (Biofield Energy Treatment) on physicochemical, spectral, and thermal properties of The Trivedi Effect®-Biofield Energy Treated sodium selenate using various analytical methods such as PXRD, PSD, FT-IR, UV-vis spectroscopy, TGA, and DSC analysis. Sodium selenate was divided into two parts – one part was control without any treatment and anoth
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Sohrab, Sayed Sartaj, Riya Raj, Amka Nagar, et al. "Chronic Inflammation’s Transformation to Cancer: A Nanotherapeutic Paradigm." Molecules 28, no. 11 (2023): 4413. http://dx.doi.org/10.3390/molecules28114413.

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The body’s normal immune response against any invading pathogen that causes infection in the body results in inflammation. The sudden transformation in inflammation leads to the rise of inflammatory diseases such as chronic inflammatory bowel disease, autoimmune disorders, and colorectal cancer (different types of cancer develop at the site of chronic infection and inflammation). Inflammation results in two ways: short-term inflammation i.e., non-specific, involves the action of various immune cells; the other results in long-term reactions lasting for months or years. It is specific and cause
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42

Núñez, M. J., J. Balboa, P. Riveiro, et al. "Effects of Psychological Stress and Alprazolam on Development of Oral Candidiasis in Rats." Clinical and Vaccine Immunology 9, no. 4 (2002): 852–57. http://dx.doi.org/10.1128/cdli.9.4.852-857.2002.

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ABSTRACT Psychological stress has been found to suppress cell-mediated immune responses that are important in limiting the proliferation of Candida albicans. Since anxiolytic drugs can restore cellular immunity in rodents exposed to stress conditions, we designed experiments conducted to evaluate the effects of alprazolam (1 mg/kg of body weight/day), a central benzodiazepine anxiolytic agonist, on the development of oral candidiasis in Sprague-Dawley rats exposed to a chronic auditory stressor. Animals were submitted to surgical hyposalivation in order to facilitate the establishment and pers
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43

Poryadin, G. V., A. N. Zakhvatov, and A. Yu Parshina. "Pathogenetic aspects of the development of psoriatic arthritis in people with generalized chronic periodontitis." Bulletin of Siberian Medicine 21, no. 4 (2023): 183–92. http://dx.doi.org/10.20538/1682-0363-2022-4-183-192.

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The pathogenetic mechanisms of progression of chronic periodontitis and psoriatic arthritis have common components in immune and inflammatory responses.The pathogenesis of chronic periodontitis involves interaction of microbial and immunological components. As a chronic immune-mediated inflammatory disease and a consequence of an infectious trigger that originally affects gingival soft tissue, periodontitis is typically characterized by periodontal destruction and damage to adjacent connective tissues. Neutrophils contribute to the development of periodontitis and participate in its progressio
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Yokota, Shumpei, Takako Miyamae, Yoshiyuki Kuroiwa, and Kusuki Nishioka. "Novel Coronavirus Disease 2019 (COVID-19) and Cytokine Storms for More Effective Treatments from an Inflammatory Pathophysiology." Journal of Clinical Medicine 10, no. 4 (2021): 801. http://dx.doi.org/10.3390/jcm10040801.

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The Novel Coronavirus Disease 2019 (COVID-19) has swept the world and caused a global pandemic. SARS-CoV-2 seems to have originated from bats as their reservoir hosts over time. Similar to SARS-CoV, this new virus also exerts its action on the human angiotensin-converting enzyme 2. This action causes infections in cells and establishes an infectious disease, COVID-19. Against this viral invasion, the human body starts to activate the innate immune system in producing and releasing proinflammatory cytokines such as IL-6, IL-1β, IL-8, TNF-α, and other chemokines, such as G-CSF, IP10 and MCPl, wh
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45

Meagher, Eileen Mary, Mahendra Kumar Trivedi, Gopal Nayak, Alice Branton, and Dahryn Trivedi. "Evaluation of the Impact of Biofield Energy Healing Treatment (The Trivedi Effect®) on the Physicochemical, Thermal, Structural, and Behavioral Properties of Magnesium Gluconate." International Journal of Nutrition and Food Sciences 6, no. 2 (2017): 71–82. https://doi.org/10.5281/zenodo.837153.

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Magnesium gluconate is a classical organometallic salt used for the prevention and treatment of magnesium deficiency diseases. The objective of the current research was to explore the influence of The Trivedi Effect® - Energy of Consciousness Healing Treatment on the physicochemical, thermal and behavioral properties of magnesium gluconate using PXRD, PSD, FT-IR, UV-vis spectroscopy, TGA, and DSC analysis. Magnesium gluconate was divided into two parts – one part was control without any Biofield Energy Treatment, while another part was treated with the Biofield Energy Healing Treatment remotel
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46

Hancharuk, Aksana, Mahendra Kumar Trivedi, Gopal Nayak, Alice Branton, and Dahryn Trivedi. "LC-MS, GC-MS, and NMR Spectroscopic Analysis of Withania somnifera (Ashwagandha) Root Extract After Treatment with the Energy of Consciousness (The Trivedi Effect®)." European Journal of Biophysics 5, no. 2 (2017): 27–37. https://doi.org/10.5281/zenodo.833581.

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Abstract:
Withania somnifera (Ashwagandha) root extract is very popular ancient herbal medicine. The current study was designed to investigate the impact of The Trivedi Effect® - Energy of Consciousness Healing Treatment on the structural characterization of the ashwagandha root extract using LC-MS, GC-MS, and NMR spectroscopy. Ashwagandha root extract was divided into two parts – one part was control, without any Biofield Energy Healing Treatment, while another part was treated with the Biofield Energy Healing Treatment remotely by eighteen renowned Biofield Energy Healers and defined as the Biofield E
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47

Benson, Sheila Maureen, Mahendra Kumar Trivedi, Gopal Nayak, Alice Branton, and Dahryn Trivedi. "Evaluation of the Impact of Biofield Energy Healing Treatment (The Trivedi Effect®) on the Physicochemical, Thermal, Structural, and Behavioral Properties of Magnesium Gluconate." International Journal of Nutrition and Food Sciences 6, no. 2 (2017): 71–82. https://doi.org/10.5281/zenodo.848485.

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Magnesium gluconate is a classical organometallic salt used for the prevention and treatment of magnesium deficiency diseases. The objective of the current research was to explore the influence of The Trivedi Effect® - Energy of Consciousness Healing Treatment on the physicochemical, thermal and behavioral properties of magnesium gluconate using PXRD, PSD, FT-IR, UV-vis spectroscopy, TGA, and DSC analysis. Magnesium gluconate was divided into two parts – one part was control without any Biofield Energy Treatment, while another part was treated with the Biofield Energy Healing Treatment remotel
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48

Fan, Ji, and Annette J. Schlueter. "Chronic ethanol ingestion induces peripheral tolerance by dendritic cells (36.21)." Journal of Immunology 178, no. 1_Supplement (2007): S16. http://dx.doi.org/10.4049/jimmunol.178.supp.36.21.

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Abstract As initiators of immune responses, dendritic cells (DCs) are required for antigen specific activation of na·ve T cells in the defense against infectious agents. The immune dysfunction in chronic alcoholics could be due to impaired immunostimulatory function or enhanced regulatory function of DCs by exposure to ethanol. Using a murine model of alcoholism, we previously assessed the ability of ethanol exposed DCs to stimulate T cell proliferation. (In this model, C57Bl/6 mice were administrated 20% ethanol in their drinking water, and maintained for 4 or 16 weeks without evidence of str
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49

Abdelmoula, B., and N. Bouayed Abdelmoula. "Chronic activation of inflammasome signaling complexes and enhancement of behavioral abnormalities." European Psychiatry 66, S1 (2023): S333—S334. http://dx.doi.org/10.1192/j.eurpsy.2023.731.

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IntroductionInflammasomes are cytosolic multi-component signaling platforms critical to the innate immune response to infectious diseases and the dysregulation of their activation can lead to the development of neurodegeneration and cancer.ObjectivesWe aim through this review to ass a possible interplay between dysregulation of inflammasome activation, development of chronic inflammatory disease and enhancement of behavioral abnormalities.MethodsWe comprehensively review the scientific literature using Pubmed database and other search platforms such as Google scholar to assess the role and the
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Lee, Aileen Carol, Mahendra Kumar Trivedi, Gopal Nayak, Alice Branton, and Dahryn Trivedi. "Evaluation of the Impact of Biofield Energy Healing Treatment (The Trivedi Effect) on the Physicochemical, Thermal, Structural, and Behavioral Properties of Magnesium Gluconate." International Journal of Nutrition and Food Sciences 6, no. 2 (2017): 71–82. https://doi.org/10.5281/zenodo.821280.

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Magnesium gluconate is a classical organometallic salt used for the prevention and treatment of magnesium deficiency diseases. The objective of the current research was to explore the influence of The Trivedi Effect® - Energy of Consciousness Healing Treatment on the physicochemical, thermal and behavioral properties of magnesium gluconate using PXRD, PSD, FT-IR, UV-vis spectroscopy, TGA, and DSC analysis. Magnesium gluconate was divided into two parts – one part was control without any Biofield Energy Treatment, while another part was treated with the Biofield Energy Healing Treatment remotel
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