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Journal articles on the topic 'Responsible tact'

Author: Grafiati
Published: 2 June 2025
Last updated: 31 July 2025

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1

Black, Cheryl. "Technique and Tact: Nina Moise Directs the Provincetown Players." Theatre Survey 36, no. 1 (1995): 55–64. http://dx.doi.org/10.1017/s0040557400006487.

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Historians of the Provincetown Players generally recognize Nina Moise as an individual who made a significant contribution to the company at a crucial period in its existence. Those who acknowledge her as an important member of the group commonly agree that Moise was Provincetown's first professional director and that her success as a director facilitated a shift away from amateurish collectivism toward more professional production techniques. That Nina Moise was largely responsible for this critical transformation in the company's production policies is not in dispute; the factors underlying
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2

Manu, G. "Critical Analysis of Dr. B R Ambedkar's Vision." AKSHARASURYA JOURNAL 06, no. 05 (2025): 282 to 293. https://doi.org/10.5281/zenodo.15504841.

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The focus of this study is intended to identify the critical analysis of Ambedkar’s idea in the stimulus vision of modern concepts. The acceleration of those visions has created a common bearing of things that may polish remaining restructured questions to ask through the fundamental social opportunities, equalities, democratic conservation and representation possibility in the matter of re-union of constitutional sustainability and integrity of sovereign ruling with or without political stamina. Provided that the critical intensity has made a clear picture of responsible tact and non-re
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3

Gautam, Devi Prasad. "Responsible Writing of Violence: A Study of Select Partition Stories." Advances in Social Sciences Research Journal 8, no. 7 (2021): 8–25. http://dx.doi.org/10.14738/assrj.87.10477.

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This paper analyzes select Partition stories such as Bhisham Sahni’s “Pali,” K. S. Duggal’s “Pakistan Zindabad,” Ishmat Chughtai’s “Roots,” S.H. Vatsyayan’s “The Avenger,” and Atin Bandhopadhyay’s “Infidel” which realistically portray the cataclysmic times of the Subcontinent in 1947. The paper shows that though the stories depict some chilling scenes, they concentrate more on the psychological impact of violence on the characters and the positive aspects of humanitarian gestures seen during the dismal days in South Asian history. With much tact, the authors approach the subject and document t
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Gherasie, Cosmin, Cornel Zamfirescu, Madlena Nen, Bogdan Saftiuc, and Octavia Albu. "Transformational Leadership Efficiency in an Organization." Proceedings of the International Conference on Business Excellence 18, no. 1 (2024): 1776–85. http://dx.doi.org/10.2478/picbe-2024-0149.

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Abstract The efficiency of the transformative leader in an organization is given by the following factors: charisma, intelligence and inspiration, intellectual stimulation, and consideration for the individual. The charismatic emotional bond eliminates the emotional and logical resistance to change. The intellectual stimulation offers new solutions and innovations and it makes the followers responsible. The transformative leader, regardless of whether he is at the base of his career or is well-experienced, motivates the subordinates through interpersonal tact, judgment, confidence, respect, an
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5

Drabarek, Anna. "Routine, tact, and disciple as components of the subject’s identity in the context of its corporeality." Horyzonty Wychowania 22, no. 62 (2023): 85–94. http://dx.doi.org/10.35765/hw.2023.2262.10.

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RESEARCH OBJECTIVE : Deliberations on identity of the subject first of allrefer to difficulties in trying to define to notion itself and the identity of the subject in the context of his corporeality.
 THE RESEARCH PROBLEMS AND METHODS: The literature analysis method. The word identity may be defined as identicality at a given time and place . The problem of identity is analyzed on the social plan.
 THE PROCESS OF ARGUMENTATION: The text presents the definitions of the concepts used, the theoretical foundations and historical outline. 
 RESEARCH RESULTS: When describing the iden
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6

Rameshbhai Patel, Kaushal. "Harmonizing Sustainability, Functionality, and Cost: Navigating Responsible Packaging Innovations in Modern Supply Chains." American Journal of Economic and Management Business (AJEMB) 2, no. 8 (2023): 287–300. http://dx.doi.org/10.58631/ajemb.v2i8.51.

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The notion of responsible packaging innovation has become a key tenet in the current supply chain architecture. This essay examines the complex interplay between cost, usability, and sustainability in the context of packaging methods. The shifting nature of packaging trends from traditional uses to modern sustainable solutions emphasizes the role's flexibility. The sustainability imperative is examined, with a focus on how packaging materials affect the environment and how the regulatory environment is changing. Responsible packaging integration into supply chains necessitates multi-stakeholde
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Silva, Manuel Fernando, Benedita Malheiro, Pedro Guedes, Abel Duarte, and Paulo Ferreira. "Collaborative Learning with Sustainability-driven Projects: A Summary of the EPS@ISEP Programme." International Journal of Engineering Pedagogy (iJEP) 8, no. 4 (2018): 106. http://dx.doi.org/10.3991/ijep.v8i4.8260.

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This paper describes the collaborative learning environment, aligned with the United Nations Millennium Development Goals, provided by the European Project Semester (EPS). EPS is a one semester capstone project programme offered by eighteen European engineering schools as part of their student ex-change programme portfolio. In this international programme, students are organized in teams, grouping individuals from diverse academic backgrounds and nationalities. The teams, after choosing a project proposal, become fully responsible for the conduction of their projects. By default, project propo
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Kern, Edmund. "Counter-Reformation Sanctity: The Bollandists' Vita of Blessed Hemma of Gurk." Journal of Ecclesiastical History 45, no. 3 (1994): 412–34. http://dx.doi.org/10.1017/s0022046900017061.

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It is now commonplace for historians of religion to treat the creation of saints as a political process that included such issues as doctrinal orthodoxy, church authority and popular practices and beliefs. The early twentieth-century Bollandist scholar of sanctity, Hippolyte Delehaye sj, touched on these when he considered the problems facing the critical, but devout, hagiographer in his history, The work of the Bollandists:To question the lawfulness of the cult of a saint, or to raise doubts as to the authenticity of his relics, were issues which could not in most cases remain theoretical, bu
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9

A, Coulibaly, Maïga A. S, Sow D, et al. "Social Repercussions of Labial-Alveolar-Palatal Clefts in African." SAS Journal of Surgery 7, no. 12 (2021): 781–83. http://dx.doi.org/10.36347/sasjs.2021.v07i12.008.

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Labial-alveolar-palatal clefts (LAPC) remain a wide spread congenital malformation throughout the world, the psychological impact of its diagnosis notification whether it is antenatal or postnatal period, could lead to emotional upheaval and vulnerability in parents. The objective of this work was to describe the impact of labial-alveolar-palatal clefts on the social behaviors of parents of children suffered from this malformation in our context. This was a descriptive cross-sectional study conducted in Mali from March 2020 to February 2021 and involved mothers of children with labial-alveolar
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10

CIORBEA, Valentin, and Dan-Dragoș SICHIGEA. "August 1944 la Constanța: cazul contraamiralului Horia Macellariu." Gândirea Militară Românească 2021, no. 4 (2021): 288–303. http://dx.doi.org/10.55535/gmr.2021.4.17.

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This paper focuses on the role of the Romanian Royal Navy and of the personality of the most capable commander of its maritime forces during the campaign in the East, in the 23 August 1944 decisive moments – Rear Admiral Horia Macellariu. In the context of the country’s exit from the alliance with Germany and of the political-military changes, and under the impact of the proclamation issued by King Mihai I, in Constanța, the problem for the commanders of the Royal Navy was very sensitive: the detachment from the RomanianGerman mixed command. The situation was characterised by uncertainties, th
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CIORBEA, Valentin, and Dan-Dragoș SICHIGEA. "August 1944 in Constanța. The Case of Rear Admiral Horia Macellariu." Romanian Military Thinking 2021, no. 4 (2021): 288–303. http://dx.doi.org/10.55535/rmt.2021.4.17.

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This paper focuses on the role of the Romanian Royal Navy and of the personality of the most capable commander of its maritime forces during the campaign in the East, in the 23 August 1944 decisive moments – Rear Admiral Horia Macellariu. In the context of the country’s exit from the alliance with Germany and of the political-military changes, and under the impact of the proclamation issued by King Mihai I, in Constanța, the problem for the commanders of the Royal Navy was very sensitive: the detachment from the RomanianGerman mixed command. The situation was characterised by uncertainties, th
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12

Ellison, Patricia H., and Claire B. Kopp. "A Note on Interdisciplinary Research in Developmental/Behavioral Pediatrics/Psychology." Pediatrics 75, no. 5 (1985): 883–86. http://dx.doi.org/10.1542/peds.75.5.883.

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In sum, we have offered a few observations about the practice of interdisciplinary research. Now, in addition to our rather specific suggestions, we want to add a few general comments about the interactions of professionals who are actually involved in interdisciplinary research. Collaboration between physicians and psychologists can be enriching, stimulating, and rewarding. But it can also be problematic, because the former do not have much exposure to research and the latter do not have much exposure to clinical issues. Bringing these skills together may require many hours of discussion and
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Skenderović, Ibro. "THE IMPORTANCE OF RHETORIC IN TEACHING." KNOWLEDGE INTERNATIONAL JOURNAL 31, no. 6 (2019): 1859–71. http://dx.doi.org/10.35120/kij31061859s.

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This paper presents activities that can be used in order to enforce the use of rhetoric in teaching. The conversation is the method in which general, linguistic, and analytical culture comes to expression, but also the logic of students and teachers and their engagement. The conversation requires a subtle approach and impeccable knowledge of the language, didactic and various tactics, as well as mutual respect of interlocutors, where exceptional and successful answers are followed by the expressions of joy and satisfaction. The reward for successful conversation is the tact, acknowledgment, an
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14

Damjanovic, Marlen, Arun S. Kharat, Alice Eberhardt, Alexander Tomasz, and Waldemar Vollmer. "The Essential tacF Gene Is Responsible for the Choline-Dependent Growth Phenotype of Streptococcus pneumoniae." Journal of Bacteriology 189, no. 19 (2007): 7105–11. http://dx.doi.org/10.1128/jb.00681-07.

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ABSTRACT Streptococcus pneumoniae has an absolute nutritional requirement for choline, and the choline molecules are known to incorporate exclusively into the cell wall and membrane teichoic acids of the bacterium. We describe here the isolation of a mutant of strain R6 in which a single G→T point mutation in the gene tacF (formerly designated spr1150) is responsible for generating a choline-independent phenotype. The choline-independent phenotype could be transferred to the laboratory strain R6 and to the encapsulated strain D39 by genetic transformation with a PCR product or with a plasmid c
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15

Akkoyunlu, Mustafa, Nora Katsenelson, Milan Blake, and Sunita Kanswal. "Downregulation of TACI by Neisseria meningitidis type C polysaccharide vaccine is responsible for its weak immunogenicity (137.4)." Journal of Immunology 184, no. 1_Supplement (2010): 137.4. http://dx.doi.org/10.4049/jimmunol.184.supp.137.4.

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Abstract Antibodies against the capsular polysaccharide (CPS) antigen of Neisseria meningitidis are bactericidal against meningococcus. However CPSs are poorly immunogenic T cell independent type II antigens. The B cell molecule TACI is shown to be essential for the development of antibody response against CPS antigens. TACI is a receptor for the TNF family cytokines BAFF and APRIL. In this study, we have determined that the CPS of N. meningitidis-C (MCPS) inhibits BAFF or APRIL induced plasma cell development and Ig secretion from mouse B cells. Correlating with this, TACI was strongly downre
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16

Sakai, Jiro, Adam S. Coleman, and Mustafa Akkoyunlu. "Impaired BCR-induced NFAT1 nuclear translocation is implicated in low TACI expression in newborn B lymphocytes." Journal of Immunology 198, no. 1_Supplement (2017): 195.5. http://dx.doi.org/10.4049/jimmunol.198.supp.195.5.

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Abstract Neonates and infants have impaired immune responses to immunization compared to adults, resulting in high susceptibility to microbial infection. B cells have a central role in humoral immunity to immunization and infection, and signals via B cell receptor (BCR) are essential for the development and maintenance of B lymphocytes. T cell-independent type 2 (TI-II) antigens activate B lymphocytes through BCR and transmembrane activator and CAML interactor (TACI). Newborns, however, are unable to generate TI-II responses, partly because TACI expression is severely reduced in newborn B cell
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17

Code, Lorraine. "Thinking Ecologically, Knowing Responsibly." Environmental Philosophy 17, no. 1 (2020): 19–37. http://dx.doi.org/10.5840/envirophil20201716.

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This essay extends my engagements with questions of epistemic agency and the politics of epistemic location, in Epistemic Responsibility and in Ecological Thinking to consider how questions of understanding and of certainty play diversely into human and other ecological circumstances. In so doing, it opens lines of inquiry not immediately available in standard western-northern approaches to epistemology with their concentration on medium-sized physical objects in their presupposed neutrality and replicability. Working from a tacit assumption that knowing and knowers are always situated, and th
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18

SCHANTL, Julia A., Marcel ROZA, Peter van KERKHOF, and Ger J. STROUS. "The growth hormone receptor interacts with its sheddase, the tumour necrosis factor-alpha-converting enzyme (TACE)." Biochemical Journal 377, no. 2 (2004): 379–84. http://dx.doi.org/10.1042/bj20031321.

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Proteolysis of the GHR (growth hormone receptor) occurs at the cell surface and results in the release of its extracellular domain, the GHBP (growth hormone-binding protein). TACE (tumour necrosis factor-α-converting enzyme) has been identified as a putative protease responsible for GHR cleavage. However, GHR–TACE interaction has not been observed until now. Here, we identified TACE in Chinese hamster cells and confirmed processing and cell-surface expression. Interaction between GHR and TACE was only observed after growth hormone binding. As the growth hormone–GHR2 complex is a poor substrate
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19

Painter-Morland, Mollie. "Philosophical assumptions undermining responsible management education." Journal of Management Development 34, no. 1 (2015): 61–75. http://dx.doi.org/10.1108/jmd-06-2014-0060.

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Purpose – The purpose of this paper is to perform a philosophical interrogation of some assumptions that underpin management education. It offers an analysis of how these assumptions may influence the promotion the responsible management agenda within business schools. Design/methodology/approach – This paper is a theoretical exploration based on a literature review and philosophical analysis. Findings – The ontological and epistemological assumptions that underpin management education pose barriers to responsible management education. A combination of ontological and epistemological assumptio
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20

Smith, Christy M. "CE: Recognizing Transfusion-Associated Circulatory Overload." AJN, American Journal of Nursing 123, no. 11 (2023): 34–41. http://dx.doi.org/10.1097/01.naj.0000995356.33506.f5.

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ABSTRACT Transfusion-associated circulatory overload (TACO) is the leading cause of transfusion-related deaths in the United States, accounting for more than 30% of fatalities reported to the Food and Drug Administration between 2016 and 2020. However, TACO is widely considered to be an underdiagnosed and underreported complication of blood transfusions, and its exact incidence is unknown. One of the reasons for this is a lack of recognition of TACO and its signs and symptoms, especially as the definition of TACO has been updated twice since 2018 without full dissemination to nurses, who are r
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Liu, Lunhua, Windy R. Allman, Adam S. Coleman, Kazuto Takeda, and Mustafa Akkoyunlu. "TACI deficiency delays the onset of systemic lupus erythematosus symptoms and improves the survival of MRL/Lpr mouse." Journal of Immunology 198, no. 1_Supplement (2017): 207.17. http://dx.doi.org/10.4049/jimmunol.198.supp.207.17.

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Abstract Systemic Lupus Erythematosus (SLE) is an autoimmune disease characterized by the production of autoantibodies and immune-complex deposition in organs such as skin and kidney. Ablation of BAFF with anti-BAFF antibodies alleviates SLE symptoms but the receptor responsible for the generation of pathogenic antibodies has been controversial. Since TACI is critical in the development of antibody secreting plasma cells, we evaluated the contribution of TACI in the formation of autoantibodies and the development of SLE in TACI deficient “lupus mouse”, generated by backcrossing the lupus prone
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Liu, Lunhua, Windy R. Allman, Adam S. Coleman, Shafiuddin Siddiqui, and Mustafa Akkoyunlu. "TACI-deficient macrophages alleviate metabolic disease symptoms in obese mice." Journal of Immunology 198, no. 1_Supplement (2017): 207.6. http://dx.doi.org/10.4049/jimmunol.198.supp.207.6.

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Abstract TACI (transmembrane activator and calcium-modulator and cyclophilin ligand interactor) is one of receptors for the TNF superfamily cytokines BAFF (B cell activating factor) and APRIL (A Proliferation Inducing Ligand). In this study, we investigated the role of TACI in high fat diet induced obesity and metabolic disease. Compared to WT mice, TACI KO mice exhibited less weight gain, decreased body fat, enhanced glucose tolerance and insulin sensitivity. Improved metabolic changes in TACI KO mice were accompanied by significantly less accumulation of CD8+ T cells and F4/80+CD11c+ inflamm
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Akkoyunlu, Mustafa, Nora Katsenelson, Kadriye Uslu, and Windy Allman. "Crucial role for TACI in TLR activation and macrophage phenotype determination (P1206)." Journal of Immunology 190, no. 1_Supplement (2013): 138.2. http://dx.doi.org/10.4049/jimmunol.190.supp.138.2.

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Abstract Transmembrane activator and calcium-modulator and cyclophilin ligand interactor (TACI) regulates antibody responses to T cell independent type 2 (TI-2) antigens such as polysaccharides. However, it is not known whether TACI is important in generation of Ab response against T cell dependent (TD) antigens. In this study, we investigated the role of TACI in Ab responses against Neisseria meningitidis type C polysaccharide-tetanus toxoid conjugate (MCPS-TT) vaccine. We found that TACI-/- mice had lower amounts of Abs against MCPS and TT compared to WT mice. More importantly, even the pote
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Drdla, K., and R. Müller. "Temperature thresholds for polar stratospheric ozone loss." Atmospheric Chemistry and Physics Discussions 10, no. 11 (2010): 28687–720. http://dx.doi.org/10.5194/acpd-10-28687-2010.

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Abstract. Low stratospheric temperatures are known to be responsible for heterogeneous chlorine activation that leads to polar ozone depletion. Here, we discuss the temperature threshold below which substantial chlorine activation occurs. We suggest that the onset of chlorine activation is dominated by reactions on cold binary aerosol particles, without formation of polar stratospheric clouds (PSCs), i.e. without significant uptake of HNO3 from the gas-phase. Using reaction rates on cold binary aerosol, a chlorine activation threshold temperature, TACL, is derived. At typical stratospheric con
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Scott, Alasdair J., Kieran P. O'Dea, David O'Callaghan та ін. "Reactive Oxygen Species and p38 Mitogen-activated Protein Kinase Mediate Tumor Necrosis Factor α-Converting Enzyme (TACE/ADAM-17) Activation in Primary Human Monocytes". Journal of Biological Chemistry 286, № 41 (2011): 35466–76. http://dx.doi.org/10.1074/jbc.m111.277434.

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Tumor necrosis factor α-converting enzyme (TACE) is responsible for the shedding of cell surface TNF. Studies suggest that reactive oxygen species (ROS) mediate up-regulation of TACE activity by direct oxidization or modification of the protein. However, these investigations have been largely based upon nonphysiological stimulation of promonocytic cell lines which may respond and process TACE differently from primary cells. Furthermore, investigators have relied upon TACE substrate shedding as a surrogate for activity quantification. We addressed these concerns, employing a direct, cell-based
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Pérez, Liliana, John E. Kerrigan, Xiaojin Li, and Huizhou Fan. "Substitution of methionine 435 with leucine, isoleucine, and serine in tumor necrosis factor alpha converting enzyme inactivates ectodomain shedding activity." Biochemistry and Cell Biology 85, no. 1 (2007): 141–49. http://dx.doi.org/10.1139/o06-179.

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Tumor necrosis factor alpha (TNF-α) converting enzyme (TACE) is a zinc metalloprotease that has emerged as a general sheddase, which is responsible for ectodomain release of numerous membrane proteins, including the proinflammatory cytokine TNF-α, the leukocyte adhesin l-selectin and epidermal growth factor receptor ligand-transforming growth factor α (TGF-α), and related family members. Structurally, TACE belongs to a large clan of proteases, designated the metzincins, because TACE possesses a conserved methionine (Met435), frequently referred to as the met-turn residue, in its active site. A
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Damian, Silvia, Anna Tessari, Giuseppe Capri, et al. "Hepatic trans-arterial chemoembolization (TACE) in metastatic breast cancer." Journal of Clinical Oncology 31, no. 15_suppl (2013): e12017-e12017. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.e12017.

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e12017 Background: Liver metastasis is one of the most frequent cause of death in breast cancer patients. Among loco-regional approaches available for solid tumor liver metastasis, TACE allows a prolonged intra-lesion exposure to chemotherapeutic agents. Initial studies have highlighted a benefit in terms of response rate (RR) and overall survival (OS) in breast cancer patients treated with TACE versus systemic chemotherapy. Methods: We have retrospectively evaluated 14 patients affected by breast cancer with liver metastasis. Patients had been selected for liver TACE according to the presence
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Solomon, Kimberly A., Nancy Pesti, Guoxin Wu та Robert C. Newton. "Cutting Edge: A Dominant Negative Form of TNF-α Converting Enzyme Inhibits ProTNF and TNFRII Secretion". Journal of Immunology 163, № 8 (1999): 4105–8. http://dx.doi.org/10.4049/jimmunol.163.8.4105.

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Abstract TNF-α converting enzyme (TACE) is the protease responsible for processing proTNF from the 26-kDa membrane-anchored precursor to the secreted 17-kDa TNF-α. We show here that a deletion mutant of TACE (dTACE), lacking the pro and catalytic domains of the protease, acts as a dominant negative for proTNF processing in transfected HEK293 cells. We used the same system to test the effect of dTACE on TNFRII processing. Overexpression of dTACE with TNFRII resulted in >80% inhibition of TNFRII shedding. Although significant inhibition of TNF-α and TNFRII shedding was achieved with dTACE
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Zheng, Fan, Tianpeng Li, Dong-yan Jin, et al. "Csi1p recruits alp7p/TACC to the spindle pole bodies for bipolar spindle formation." Molecular Biology of the Cell 25, no. 18 (2014): 2750–60. http://dx.doi.org/10.1091/mbc.e14-03-0786.

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Accurate chromosome segregation requires timely bipolar spindle formation during mitosis. The transforming acidic coiled-coil (TACC) family proteins and the ch-TOG family proteins are key players in bipolar spindle formation. They form a complex to stabilize spindle microtubules, mainly dependent on their localization to the centrosome (the spindle pole body [SPB] in yeast). The molecular mechanism underlying the targeting of the TACC–ch-TOG complex to the centrosome remains unclear. Here we show that the fission yeast Schizosaccharomyces pombe TACC orthologue alp7p is recruited to the SPB by
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Arizumi, Tadaaki, Tomohiro Minami, Hirokazu Chishina, et al. "Time to Transcatheter Arterial Chemoembolization Refractoriness in Patients with Hepatocellular Carcinoma in Kinki Criteria Stages B1 and B2." Digestive Diseases 35, no. 6 (2017): 589–97. http://dx.doi.org/10.1159/000480208.

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Background: Transarterial chemoembolization (TACE) is recommended for patients with hepatocellular carcinoma (HCC) in Barcelona Clinic Liver Cancer (BCLC) stage B. However, because of the heterogeneity of HCC in BCLC stage B; various subclassification systems have been proposed to predict the prognosis of patients. Previously, we proposed the Kinki criteria for precise classification of HCC cases in BCLC stage B. In this study, we compared the time to TACE refractoriness in HCC patients with Kinki criteria substages B1 and B2-HCC. Summary: Between January 2006 and December 2013, 592 HCC patien
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Wolfe, S. E. "What's your story? Practitioners' tacit knowledge and water demand management policies in southern Africa and Canada." Water Policy 11, no. 4 (2009): 489–503. http://dx.doi.org/10.2166/wp.2009.059.

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Water efficiency research has focused on consumption rates and the tools—for example, pricing—designed to modify consumers' demand. But municipal practitioners can also be a highly influential group and have been neglected in the conventional water demand management (WDM) research. To understand better how to make WDM policy implementation more successful, practitioners “tacit knowledge” must be identified and examined. Tacit knowledge consists of deep beliefs and values about the way the world works and is important. Grounded in practical experience, tacit knowledge is informal, unspoken and
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Drdla, K., and R. Müller. "Temperature thresholds for chlorine activation and ozone loss in the polar stratosphere." Annales Geophysicae 30, no. 7 (2012): 1055–73. http://dx.doi.org/10.5194/angeo-30-1055-2012.

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Abstract. Low stratospheric temperatures are known to be responsible for heterogeneous chlorine activation that leads to polar ozone depletion. Here, we discuss the temperature threshold below which substantial chlorine activation occurs. We suggest that the onset of chlorine activation is dominated by reactions on cold binary aerosol particles, without the formation of polar stratospheric clouds (PSCs), i.e. without any significant uptake of HNO3 from the gas phase. Using reaction rates on cold binary aerosol in a model of stratospheric chemistry, a chlorine activation threshold temperature,
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Wang, Yuhui, and Hei Sook Sul. "Ectodomain Shedding of Preadipocyte Factor 1 (Pref-1) by Tumor Necrosis Factor Alpha Converting Enzyme (TACE) and Inhibition of Adipocyte Differentiation." Molecular and Cellular Biology 26, no. 14 (2006): 5421–35. http://dx.doi.org/10.1128/mcb.02437-05.

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ABSTRACT Preadipocyte factor 1 (Pref-1), an epidermal growth factor repeat containing transmembrane protein found in the preadipocytes, inhibits adipocyte differentiation in vitro and in vivo. Here, we examined the processing of membrane form of Pref-1A to release the 50-kDa soluble form that inhibits adipocyte differentiation. The ectodomain cleavage of Pref-1 is markedly enhanced by phorbol 12-myristate 13-acetate in a dose- and time-dependent manner. The basal and stimulated cleavage is inhibited by the broad metalloproteinase inhibitor GM6001, a fact that suggests that cleavage of membrane
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Coste, Alix, Anna Selmecki, Anja Forche, et al. "Genotypic Evolution of Azole Resistance Mechanisms in Sequential Candida albicans Isolates." Eukaryotic Cell 6, no. 10 (2007): 1889–904. http://dx.doi.org/10.1128/ec.00151-07.

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ABSTRACT TAC1 (for transcriptional activator of CDR genes) is critical for the upregulation of the ABC transporters CDR1 and CDR2, which mediate azole resistance in Candida albicans. While a wild-type TAC1 allele drives high expression of CDR1/2 in response to inducers, we showed previously that TAC1 can be hyperactive by a gain-of-function (GOF) point mutation responsible for constitutive high expression of CDR1/2. High azole resistance levels are achieved when C. albicans carries hyperactive alleles only as a consequence of loss of heterozygosity (LOH) at the TAC1 locus on chromosome 5 (Chr
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Hildebrand, Joanne, and Gail Bishop. "TRAF6, a new member of the proximal signaling complex recruited by BAFFR and TACI in B lymphocytes (34.1)." Journal of Immunology 184, no. 1_Supplement (2010): 34.1. http://dx.doi.org/10.4049/jimmunol.184.supp.34.1.

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Abstract The cytokines BAFF (B-cell activating factor of the TNF family, BLyS) and APRIL (a proliferation-inducing ligand) activate several major signaling cascades responsible for B-cell survival and homeostasis. Made primarily by myeloid cells, BAFF binds and activates three cell membrane receptors; BCMA (B-cell maturation antigen), TACI (transmembrane activator and CAML interactor), and BAFF-R (BAFF Receptor, BR3), while APRIL binds TACI and BCMA. Studies of genetically altered mice demonstrate that TACI and BCMA perform niche roles in B-cell Ig isotype switching and plasma cell maintenance
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Wang, Hong, Ranran Tu, Lianping Sun, et al. "Tiller Angle Control 1 Is Essential for the Dynamic Changes in Plant Architecture in Rice." International Journal of Molecular Sciences 23, no. 9 (2022): 4997. http://dx.doi.org/10.3390/ijms23094997.

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Plant architecture is dynamic as plants develop. Although many genes associated with specific plant architecture components have been identified in rice, genes related to underlying dynamic changes in plant architecture remain largely unknown. Here, we identified two highly similar recombinant inbred lines (RILs) with different plant architecture: RIL-Dynamic (D) and RIL-Compact (C). The dynamic plant architecture of RIL-D is characterized by ‘loosetiller angle (tillering stage)–compact (heading stage)–loosecurved stem (maturing stage)’ under natural long-day (NLD) conditions, and ‘loosetiller
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Caescu, Cristina I., Grace R. Jeschke, and Benjamin E. Turk. "Active-site determinants of substrate recognition by the metalloproteinases TACE and ADAM10." Biochemical Journal 424, no. 1 (2009): 79–88. http://dx.doi.org/10.1042/bj20090549.

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The metalloproteinases TACE [tumour necrosis factor α-converting enzyme; also known as ADAM17 (a disintegrin and metalloproteinase 17)] and ADAM10 are the primary enzymes responsible for catalysing release of membrane-anchored proteins from the cell surface in metazoan organisms. Although the repertoire of protein substrates for these two proteases is partially overlapping, each one appears to target a subset of unique proteins in vivo. The mechanisms by which the two proteases achieve specificity for particular substrates are not completely understood. We have used peptide libraries to define
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Killock, David J., та Aleksandar Ivetić. "The cytoplasmic domains of TNFα-converting enzyme (TACE/ADAM17) and L-selectin are regulated differently by p38 MAPK and PKC to promote ectodomain shedding". Biochemical Journal 428, № 2 (2010): 293–304. http://dx.doi.org/10.1042/bj20091611.

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L-selectin mediates the initial tethering and subsequent rolling of leucocytes along luminal walls of inflamed venules. TACE [TNFα (tumour necrosis factor α)-converting enzyme] is responsible for cleaving the membrane-proximal extracellular domain of L-selectin (also known as shedding), which reduces the efficiency of leucocyte recruitment to sites of inflammation. Many reports have highlighted roles for PKC (protein kinase C) and p38 MAPK (mitogen-activated protein kinase) in promoting L-selectin shedding with little insight into the mechanism involved. By using PMA and the phosphatase inhibi
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Du, Zefeng, Zhicheng Lai, Anna Kan, MinKe He, and Ming Shi. "Sorafenib plus hepatic arterial infusion chemotherapy versus sorafenib plus transarterial chemoembolization in advanced hepatocellular carcinoma: An update on SHATA-001 study." Journal of Clinical Oncology 43, no. 16_suppl (2025): 4100. https://doi.org/10.1200/jco.2025.43.16_suppl.4100.

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4100 Background: Although sorafenib plus transcatheter arterial chemoembolization (SoraTACE) has been widely applied for advanced hepatocellular carcinoma (HCC) in most Asian countries, sorafenib plus hepatic arteria infusion chemotherapy (SoraHAIC) may be a better alternative. Herein, we compared the efficacy and safety between the two groups in advanced HCC. Additionally, we validated a predictive model from our previous phase III trial (NCT02973685, cohort1). Methods: This phase III trial (NCT02856126) recruited participants with advanced HCC. Eligible participants were randomly assigned (2
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Wang, Qianyi, Zhuo Luo, Danfeng Li, et al. "Investigation of the Therapeutic Effect of Total Alkaloids of Corydalis saxicola Bunting on CCl4-Induced Liver Fibrosis in Rats by LC/MS-Based Metabolomics Analysis and Network Pharmacology." Metabolites 13, no. 1 (2022): 9. http://dx.doi.org/10.3390/metabo13010009.

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: Liver fibrosis is a pathological result of liver injury that usually leads to a pathophysiological wound healing response. The total alkaloids of Corydalis saxicola Bunting (TACS) have been used for hepatoprotective effects on the liver. However, its exact therapeutic mechanisms of liver fibrosis are not yet well understood. To explore the potential anti-fibrosis mechanism of TACS, metabolomics coupled with network pharmacology were applied to reveal the underlying mechanisms. Ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF/MS) combined with mu
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González, Ana, Daniel Llull, María Morales, Pedro García, and Ernesto García. "Mutations in the tacF Gene of Clinical Strains and Laboratory Transformants of Streptococcus pneumoniae: Impact on Choline Auxotrophy and Growth Rate." Journal of Bacteriology 190, no. 12 (2008): 4129–38. http://dx.doi.org/10.1128/jb.01991-07.

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ABSTRACT The nutritional requirement that Streptococcus pneumoniae has for the aminoalcohol choline as a component of teichoic and lipoteichoic acids appears to be exclusive to this prokaryote. A mutation in the tacF gene, which putatively encodes an integral membrane protein (possibly, a teichoic acid repeat unit transporter), has been recently identified as responsible for generating a choline-independent phenotype of S. pneumoniae (M. Damjanovic, A. S. Kharat, A. Eberhardt, A. Tomasz, and W. Vollmer, J. Bacteriol. 189:7105-7111, 2007). We now report that Streptococcus mitis can grow in chol
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Coste, Alix T., Mahir Karababa, Françoise Ischer, Jacques Bille, and Dominique Sanglard. "TAC1, Transcriptional Activator of CDR Genes, Is a New Transcription Factor Involved in the Regulation of Candida albicans ABC Transporters CDR1 and CDR2." Eukaryotic Cell 3, no. 6 (2004): 1639–52. http://dx.doi.org/10.1128/ec.3.6.1639-1652.2004.

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ABSTRACT The ABC transporter genes CDR1 and CDR2 can be upregulated in Candida albicans developing resistance to azoles or can be upregulated by exposing cells transiently to drugs such as fluphenazine. The cis-acting drug-responsive element (DRE) present in the promoters of both genes and necessary for their upregulation contains 5′-CGG-3′ triplets that are often recognized by transcriptional activators with Zn(2)-Cys(6) fingers. In order to isolate regulators of CDR1 and CDR2, the C. albicans genome was searched for genes encoding proteins with Zn(2)-Cys(6) fingers. Interestingly, three of t
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Hoydal, Kjartan. "Viewpoint: the interface between scientific advice and fisheries managementa." ICES Journal of Marine Science 64, no. 4 (2007): 846–50. http://dx.doi.org/10.1093/icesjms/fsm010.

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Abstract Hoydal, K. 2007. Viewpoint: the interface between scientific advice and fisheries management. – ICES Journal of Marine Science, 64: 846–850. Basic elements in responsible, robust, and sustainable fishery management frameworks are well understood and easily listed. Common sense and international law underline the prominent role of science in management. Most managers request peer-reviewed advice based on an objective assessment of the impact of fisheries on marine ecosystems, to create a basis for sustainable and profitable fisheries. Management systems in the North Atlantic rely exten
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Brown, Alice, Lisa Fletcher, and Cettina Raccuia. "Strategies for Impact When Working In-house : Learnings from RAC CoLAB, an in-house service design and innovation team." Touchpoint 15, no. 3 (2024): 77–78. https://doi.org/10.30819/touchpoint.15-3.18.

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In-house service design teams can support larger organisations be responsive to changing customer expectations and technological advancements. There is extensive tacit knowledge unique to both establishing an in-house service design team and iterating its practices so that its work is valued and impactful.
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Küper, Christoph, Helmut Bartels, Maria-Luisa Fraek, Franz X. Beck та Wolfgang Neuhofer. "Ectodomain shedding of pro-TGF-α is required for COX-2 induction and cell survival in renal medullary cells exposed to osmotic stress". American Journal of Physiology-Cell Physiology 293, № 6 (2007): C1971—C1982. http://dx.doi.org/10.1152/ajpcell.00404.2007.

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In the renal medulla, cyclooxygenase (COX)-2 is induced by osmotic stress as present in this kidney region during antidiuresis. Increasing evidence suggests that EGF receptor (EGFR) signaling is involved in this process. The aim of the present study was to examine the mechanisms responsible for COX-2 expression and PGE2 production during hypertonic conditions and to identify potential autocrine/paracrine EGFR ligands. Immunohistochemisty and Western blot analysis revealed abundant expression of the pro-EGFR ligand pro-transforming growth factor (TGF)-α in renal medullary cells in vivo and in c
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Lin, Chieh-Peng, Her-Ting Huang, and Tse Yao Huang. "The effects of responsible leadership and knowledge sharing on job performance among knowledge workers." Personnel Review 49, no. 9 (2020): 1879–96. http://dx.doi.org/10.1108/pr-12-2018-0527.

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PurposeDrawing upon social exchange theory, this study justified the indirect effects of responsible leadership and knowledge sharing on job performance through the mediation of work engagement and helping initiatives. Job tenure was examined as a moderator.Design/methodology/approachThe hypotheses of this study were empirically tested with structural equation modeling (SEM) and moderated regression analyses. This study conducted a field survey on 512 knowledge workers who employed a high portion of or highly specialized tacit knowledge to do their job.FindingsThis research presented that both
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Uslu, Kadriye, Adam S. Coleman, Windy R. Allman, et al. "Impaired B Cell Receptor Signaling Is Responsible for Reduced TACI Expression and Function in X-Linked Immunodeficient Mice." Journal of Immunology 192, no. 8 (2014): 3582–95. http://dx.doi.org/10.4049/jimmunol.1203468.

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48

Rawls, Anne W., Waverly Duck, and Jason Turowetz. "Problems Establishing Identity/Residency in a City Neighborhood during a Black/White Police–Citizen Encounter: Reprising Du Bois’ Conception of Submission as “Submissive Civility”." City & Community 17, no. 4 (2018): 1015–50. http://dx.doi.org/10.1111/cico.12345.

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This article revisits W.E.B. Du Bois' (1943) conception of “The Submissive Man” in the context of a Black/White police–citizen encounter. Du Bois argued that submission to democratic principles that place the well–being of the whole over the individual is a Black American ideal, which offers a necessary counter–balance to the individualism of the dominant White “Strong Man” ideal. We contrast this preference for “submission” and “cooperation” in dealing with racism with White American individualism, referring to these as “preferences” in conflicting Black/White “Interaction Orders”. In the pol
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Fladung, Matthias. "Targeted CRISPR/Cas9-Based Knock-Out of the Rice Orthologs TILLER ANGLE CONTROL 1 (TAC1) in Poplar Induces Erect Leaf Habit and Shoot Growth." Forests 12, no. 12 (2021): 1615. http://dx.doi.org/10.3390/f12121615.

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Pyramidal-, erect- or upright-growing plant forms are characterized by narrow branch angles of shoots and leaves. The putative advantage of upright-leaf and shoot habit could be a more efficient penetration of light into lower canopy layers. Pyramidal genotypes have already been reported for various tree genotypes including peach. The paralogous rice ortholog TILLER ANGLE CONTROL 1 (TAC1) has been proposed to be the responsible gene for upright growth. However, it has not really been demonstrated for any of the pyramidal tree genotypes that a knock-out mutation of the TAC1 gene is causing pyra
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Mtsweni, Emmanuel, and Koga Gorejena. "Team Barriers to Tacit Knowledge Sharing in Software Development Project Teams." Electronic Journal of Knowledge Management 21, no. 1 (2023): 59–72. http://dx.doi.org/10.34190/ejkm.21.1.2244.

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Software Development Projects (SDPs) are being conducted at a rapid rate in response to the Fourth Industrial Revolution (4IR), even though SDPs are associated with very high failure rates. Their failure rate of SDPs has been declared as an International Crisis. SDPs are knowledge intensive in nature, whereby knowledge is essential when performing socio-technical tasks within SDPs. One of the reasons for the failure of SDPs is limited sharing of tacit knowledge within SDP teams. Limited tacit knowledge sharing within SDP teams results in the teams not being in position to perform their socio-t
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