Academic literature on the topic 'Rest cure'
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Journal articles on the topic "Rest cure"
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Sharpe, M., and S. Wessely. "Putting the rest cure to rest---again." BMJ 316, no. 7134 (March 14, 1998): 796–800. http://dx.doi.org/10.1136/bmj.316.7134.796.
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Blackie, Michael. "Reading the Rest Cure." Arizona Quarterly: A Journal of American Literature, Culture, and Theory 60, no. 2 (2004): 57–85. http://dx.doi.org/10.1353/arq.2004.0012.
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Martin, Diana. "The Rest Cure Revisited." American Journal of Psychiatry 164, no. 5 (May 2007): 737–38. http://dx.doi.org/10.1176/ajp.2007.164.5.737.
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Pearce, J. M. S. "Silas Weir Mitchell and the "rest cure"." Journal of Neurology, Neurosurgery & Psychiatry 75, no. 3 (March 1, 2004): 381. http://dx.doi.org/10.1136/jnnp.2002.002386.
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Passmore, Gayle, and Patrick Delmas. "Does cure for pain REST on Kv7 channels?" Pain 152, no. 4 (April 2011): 709–10. http://dx.doi.org/10.1016/j.pain.2011.02.040.
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Gregory, Fiona. "Performing the Rest Cure: Mrs Patrick Campbell's Ophelia, 1897." New Theatre Quarterly 28, no. 2 (May 2012): 107–21. http://dx.doi.org/10.1017/s0266464x12000218.
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In 1897 audiences welcomed Johnston Forbes-Robertson's new interpretation of Hamlet to the London stage, and his sane, intelligent Prince was received as an exciting departure from tradition. Mrs Patrick Campbell's own experiments with the role of Ophelia in this production were not so warmly greeted, critics describing her playing as ‘curiously weak’ and ‘unconvincing and unimpressive’. Campbell had rejected the conventional model of the character as emblematic of the prettiness and pathos exemplified by Ellen Terry, and instead offered a vacant, depressive, ‘beaten’ Ophelia. In this article, Fiona Gregory examines the influences behind this choice, including the actress's own experience of mental illness and the notorious ‘rest cure’. The reception of the performance is read in terms of contemporary attitudes to Ophelia and mental illness, as well as of responses to Campbell and her celebrity identity in the visual arts. Ultimately, Campbell's performance of Ophelia can be read as a ‘witness account’ of neurasthenia and the ‘rest cure’, to stand alongside texts such as Charlotte Perkins Gilman's story ‘The Yellow Wallpaper’. Fiona Gregory lectures in the Centre for Theatre and Performance at Monash University, and has published work on the career of actress Judith Anderson, Australian cultural history, and Victorian and Edwardian writers. She is currently undertaking a wide-ranging study of actresses and mental illness from the nineteenth century to the present day, drawing on historical examples and literary and cultural representations to consider the intersections of ‘hysteria’ and the ‘histrionic’.
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Bassuk, Ellen L. "The Rest Cure: Repetition or Resolution of Victorian Women's Conflicts?" Poetics Today 6, no. 1/2 (1985): 245. http://dx.doi.org/10.2307/1772132.
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Andrada Hamer, Maria, and Jan Persson. "Preoperative urethral parameters at rest and objective cure following laparoscopic colposuspension." International Urogynecology Journal 21, no. 3 (November 19, 2009): 331–36. http://dx.doi.org/10.1007/s00192-009-1034-3.
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Kolisko, Petr, Milada Sárová, Michele Oliviano, Jakub Krejčí, and Petr Uhlíř. "Influence of carlsbad thermo-mineral water on the autonomic nervous system." Acta Salus Vitae 12, no. 1 (July 11, 2024): 13–21. http://dx.doi.org/10.58743/asv2024vol12no1.334.
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The drinking cure is an essential part of Karlovy Vary spa treatment. The effect of Karlovy Vary mineral water on the autonomic nervous system has not yet been investigated. Based on case analyses, we hypothesized that the effects of the drinking cure have an effect on the functional activity of the autonomic nervous system. The prospective research study had the character of an experiment in clinical conditions. Research file: Health women n = 15, age 40-50 years. Methodology: Before and 30 min after the experimental sequence, the functional state of the autonomic nervous system was examined by the method of spectral analysis of heart rate variability in the ortho-clino-orthostatic position. The experimental sequence: rest sitting position (pre) drinking cure in a sitting position (application of 350 ml thermo-mineral water 50 °C) rest sitting position (post). The length of all monitored intervals was 300 heartbeats. Results: Pre-post status (30–50 minutes after the application of the drinking cure): an increase in the overall activity of the autonomic nervous system an increase in activity in the sympathetic and parasympathetic frequency bands reducing the heart rate blood pressure values did not change. Effects during the application of the drinking cure (comparison with a rest sitting position): a decrease in the overall activity of the autonomic nervous system an increase in sympathetic activity and decrease in parasympathetic activity an increase in heart rate an increase in systolic and diastolic blood pressure. Conclusions: A prospective research study highlighted the reflexive relationships between the digestive system and the cardiovascular system. These relationships are modulated by the autonomic nervous system. Factors that influence the effect of the drinking cure in the area of the upper part of the digestive system are: the rhythm of swallowing and the temperature of the water. Factors that influence the post-effect of the drinking cure in the area of the duodenum and jejunum they probably are: high content of free carbon dioxide and bicarbonate ions in the Carls Bad thermomineral water. These factors apparently activate the motility of the intestinal tract and have an effect on systemic changes of the functional status of the autonomic nervous system.
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Kelly, Lori Duin. "Selecting a Somatic Type: The Role of Anorexia in the Rest Cure." Journal of Medical Humanities 33, no. 1 (November 24, 2011): 15–26. http://dx.doi.org/10.1007/s10912-011-9164-2.
Full textDissertations / Theses on the topic "Rest cure"
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Muente, Tamera Lenz. "Repose, Reflections, and “Girls in Sunshine”: Frederick Carl Frieseke’s Paintings of Women, 1905–1920." University of Cincinnati / OhioLINK, 2006. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1147531632.
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Valinskis, Mindaugas. "Partnerių vieša API ir jos panaudojimas WHMCS modulyje." Bachelor's thesis, Lithuanian Academic Libraries Network (LABT), 2014. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2014~D_20140716_111722-09636.
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Įmonė UAB „Duomenų Centras“ nuomoja serverius jau 13 metų. Atlikus tyrimus paaiškėjo, kad įmonė eksportuoja apie 75% savo paslaugų į daugiau nei 130 pasaulio šalių. Prie šio rezultato labai prisidėjo Duomenų Centro partneriai iš Lietuvos ir kitų šalių. Partneris – tai svarbiausias klientas, kuris pritraukia kitus naujus klientus. Per įmonės gyvavimo metus visas perpardavinėjimo ir partnerių klientų paslaugų valdymo procesas buvo per elektorinį paštą - tai užtrunka, tokios paslaugos nėra itin patrauklios šiuolaikinėje interneto rinkoje. Todėl dokumente atskleidžiama „partnerių programa“, bei API posistemė, kuri leidžia įmonės partneriams vykdyti su paslaugomis susijusias funkcijas.The modern data center of Balticservers have been selling their services now for 13 years. The research revealed that the company exports 75% of its services to more than 130 countries worldwide. Moreover, the company has partners from Lithuania and many other countries. The product has been designed for partners that optimizes the process of reselling Balticservers services. It offers a WHMCS module which allows an easy creation and customization of services that are desired to be resold from Balticservers. Also, this includes an API communication between two separated systems that are WHMCS and Korys which Balticservers are currently developing and using in their daily work. API has been developed by using PHP scripting language, cURL and JSON technologies. The document exposes a few similar API systems’ comparison, product requirement specification, architecture’s specification, testing protocol and partners API documentation.
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Pike, Jonathan R. "A Resource Curse for Institutions: Rent Dependency and Quality of Government." Thesis, Boston College, 2010. http://hdl.handle.net/2345/1338.
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Thesis advisor: Richard, S.J. McGowanThe Natural Resource Curse literature proposes to explain why and to what extent resource-wealthy countries have poor economic growth outcomes. Most research focuses on direct economic explanations, considering the role of governing institutions exogenously if at all. One emerging branch of explanations attempts to address this shortcoming, focusing on the indirect effects of institutional deterioration on economic outcomes in resource-rich countries. I add to this emerging literature by performing an econometric analysis of 16 oil-producing nations, examining the impact of national oil rent dependency on 12 dimensions of government quality from 1987-2008. I find that oil dependency has a significant negative impact on government quality in 11 of the 12 dimensions. I also find that controlling for preexisting levels of democracy does not significantly mitigate institutional resource curse effects. This runs counter to findings about economic effects, which tend to disappear when democracy levels are high
Thesis (BA) — Boston College, 2010
Submitted to: Boston College. College of Arts and Sciences
Discipline: Economics Honors Program
Discipline: College Honors Program
Discipline: Economics
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D'Ambroso, Marika <1976>. "Con lo sguardo di chi resta. L'etica dell'accompagnamento nel nucleo di cure palliative domiciliari dell'Azienda ULSS 8 - Asolo." Master's Degree Thesis, Università Ca' Foscari Venezia, 2012. http://hdl.handle.net/10579/2263.
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Le tematiche etiche di fine vita si inseriscono all’interno di uno scenario che si caratterizza da frequenti e numerosi dibattiti che vedono il coinvolgimento dei mass media, dell’opinione pubblica, dei professionisti sanitari e non e degli esperti di bioetica.
La cura e l’assistenza ai malati in condizione di fine vita sono caratterizzate da notevoli problematiche causate dai numerosi sintomi sia fisici che psicologici che la malattia porta al malato e alla sua famiglia.
L’etica si occupa di ciò che viene considerato dall’uomo giusto o sbagliato, ossia tratta ciò che riguarda la morale e i valori dell’uomo che ne determinano il suo comportamento. La medicina vede un’applicazione sempre più forte delle tecnologie ed allora si chiede all’etica di capire come essa possa gestire le nuove potenzialità coerentemente con i suoi fini specifici, evitando che prevalga l’attitudine puramente tecnica per cui tutto ciò che si può fare si legittima di per sé. La bioetica, che si occupa delle questioni morali che nascono dal progresso della ricerca biologica, tecnologica e medica, viene chiamata in causa di fronte a quelle tecnologie che cercano di oltrepassare il limite della scienza per invadere quello della morale, provocando di conseguenza critiche, polemiche e dilemmi.
La persona inguaribile, con una ridotta aspettativa di vita, è bisognosa di assistenza continuativa durante l’accompagnamento alla morte, nei confronti del quale appare inutile il ricorso a terapie di tipo eziologico, restando possibili soltanto la somministrazione di interventi e trattamenti sintomatici di natura palliativa. Di fronte all’impossibilità di guarire diventa allora indispensabile non più curare (to cure) ma prendersi cura (to care).
La filosofia delle cure palliative sottolinea che è importante non solo intervenire sui sintomi fisici: ciò può essere settoriale rispetto alla sofferenza nella sua globalità (total pain). Lo scopo fondamentale che le cure palliative devono conseguire, soprattutto nel periodo precedente la morte della persona, è il contatto comunicativo con la stessa, contatto che si rende concreto con l’intensificazione della presenza: per la persona assistita è importante che ci sia qualcuno con cui condividere l’esperienza della vita che si conclude. Si ritiene quindi fondamentale che l’assistenza fornita al malato terminale dai servizi socio-sanitari preposti rispetti la sua qualità di vita, attraverso il controllo del dolore e il supporto psicologico alla famiglia e al malato stesso. Oltre a cercare di applicare al meglio la filosofia delle cure palliative, è opportuno che i servizi compiano periodicamente una verifica sull’attività svolta dai vari professionisti coinvolti, ad esempio attraverso la valutazione della qualità percepita, per individuare ed evidenziare punti critici e di forza dei servizi al fine di attuare, quindi, un miglioramento continuo in questo ambito di cura così delicato.
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Panzavolta, Mattia. "Isolamento e controllo degli studenti durante un’esame mediante firewall." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2020. http://amslaurea.unibo.it/20970/.
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La tesi tratta del modo con la quale gli studenti vengano isolati durante una prova d'esame al computer all'interno di un laboratorio informatico e dello sviluppo di un'applicazione che permetta l'attivazione e la disattivazione del firewall FortiGate da remoto, facendo uso delle REST API e della libreria cURL.
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Petrovsky, Nicolai. "Does Natural Resource Wealth Spoil and Corrupt Governments? A New Test of the Resource Curse Thesis." Thesis, University of North Texas, 2004. https://digital.library.unt.edu/ark:/67531/metadc4582/.
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Countries with rich natural resource endowments suffer from lower economic growth and various other ills. This work tests whether the resource curse also extends to the quality of regulation and the level of corruption. A theoretical framework is developed that informs the specification of interactive random effects models. A cross-national panel data set is used to estimate these models. Due to multicollinearity, only an effect of metals and ores exports on corruption can be discerned. Marginal effects computations show that whether nature corrupts or not crucially depends on a country's institutions. A broad tax base and high levels of education appear to serve as inoculations for countries against the side-effects of mineral wealth.
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Ribeiro, Marcilio Pelicano. "Avalia??o do petr?leo por termogravimetria para simula??o de curva PEV, fator de caracteriza??o e res?duo de carbono." Universidade Federal do Rio Grande do Norte, 2014. http://repositorio.ufrn.br:8080/jspui/handle/123456789/13029.
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Petroleum evaluation is analyze it using different methodologies, following international standards to know their chemical and physicochemical properties, contaminant levels, composition and especially their ability to generate derivatives. Many of these analyzes consuming a lot of time, large amount of samples , supplies and need an organized transportation logistics, schedule and professionals involved. Looking for alternatives that optimize the evaluation and enable the use of new technologies, seven samples of different centrifuged Brazilian oils previously characterized by Petrobras were analyzed by thermogravimetry in 25-900? C range using heating rates of 05, 10 and 20?C per minute. With experimental data obtained, characterizations correlations were performed and provided: generation of true boiling point curves (TBP) simulated; comparing fractions generated with appropriate cut standard in temperature ranges; an approach to obtain Watson characterization factor; and compare micro carbon residue formed. The results showed a good chance of reproducing simulated TBP curve from thermogravimetry taking into account the composition, density and other oil properties. Proposed correlations for experimental characterization factor and carbon residue followed Petrobras characterizations, showing that thermogravimetry can be used as a tool on oil evaluation, because your quick analysis, accuracy, and requires a minimum number of samples and consumables
A avalia??o de petr?leo consiste em analis?-lo por diferentes metodologias, seguindo normas internacionais para conhecer suas propriedades qu?micas, f?sico-qu?micas, teor de contaminantes, composi??o e principalmente sua capacidade em gerar derivados. Muitas dessas an?lises s?o demoradas, consomem uma grande quantidade de amostras, insumos e precisam de uma organizada log?stica de transporte, cronograma de realiza??o e profissionais envolvidos. Para buscar alternativas que otimizem essa avalia??o e permitam a utiliza??o de novas tecnologias, sete amostras de diferentes petr?leos brasileiros centrifugados e caracterizados previamente pela Petrobr?s foram analisadas por termogravim?trica numa faixa de temperatura de 25 a 900?C utilizando raz?es de aquecimento de 05, 10 e 20?C por minuto. Com os dados obtidos experimentalmente, foram realizadas correla??es com as caracteriza??es disponibilizadas que permitiram: a gera??o de curvas de pontos de ebuli??o verdadeiros (Curva PEV) simulada; a compara??o entre as fra??es geradas com as devidas faixas de temperaturas de corte padr?o; uma aproxima??o para obter o fator de caracteriza??o de Watson; e comparar os res?duos de carbono micro. Os resultados mostraram uma boa possibilidade de reproduzir uma curva PEV simulada a partir da termogravimetria levando em considera??o a composi??o, densidade e outras propriedades do petr?leo; as correla??es propostas experimentalmente para o fator de caracteriza??o e res?duo de carbono acompanharam as caracteriza??es informadas pela Petrobr?s, mostrando que a termogravimetria pode ser utilizada como ferramenta na avalia??o de petr?leos, apresentando rapidez na an?lise, precis?o, al?m de necessitar de uma quantidade m?nima de amostras e insumos
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Heyman, Fredrik. "Empirical studies on wages, firm performance and job turnover." Doctoral thesis, Stockholm : Economic Research Institute, Stockholm School of Economics [Ekonomiska forskningsinstitutet vid Handelshögsk.] (EFI), 2002. http://www.hhs.se/efi/summary/601.htm.
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Wadho, Waqar ahmed. "Essays on the economics of corruption." Thesis, Aix-Marseille 2, 2011. http://www.theses.fr/2011AIX24005/document.
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Cette thèse est composée de trois essais; dans le premier essai je traite les questions de la détermination, de la variance et des répercussions de la corruption. J’ai montré que la corruption est déterminée par la part des travailleurs non qualifiés sur la population. Si cette part est large alors il existe une corruption, si elle est faible la corruption est inexistante, et pour des niveaux intermédiaires, il existe une multiplicité d’équilibres. La corruption augmente les inégalités salariales entre travailleurs qualifiés et non qualifiés, et une perte de bien-être. Dans le deuxième essai je traite la question de lutte contre la corruption à travers l’incitation salariale. Avec une technologie de contrôle endogène, je montre que le gouvernement peut mieux accepter la corruption lorsqu’il est coûteux de contrôler. Lorsqu’il est optimal de combattre alors le gouvernement peut le faire soit à travers des salaires d’efficience ou soit par le contrôle. Néanmoins le rôle des salaires d’efficience dans la lutte contre la corruption est moindre dans les sociétés avec un niveau de malhonnêteté élevé. Le troisième essai traite la malédiction des ressources naturelles. Je montre que l'éducation et la corruption sont déterminées conjointement ; les ressources naturelles affectent l’incitation à investir en éducation et en ‘rent-seeking’ ce qui en retour affecte la croissance. En outre, la relation entre une abondance et la malédiction des ressources naturelles n’est pas monotone. Pour un niveau d’inégalité d’accès à l’éducation faible et un coût élevé de participation dans la vie politique, un niveau de croissance élevé et la trappe à la pauvreté coexistentThis dissertation consists of three essays. The topics cover determination, variance and repercussions of corruption (essay one), corruption deterrence through wage incentives (essay two), and natural resource curse (essay three). In the first essay, I show that for a larger population of unskilled labor, there is a widespread corruption and for a smaller population there is no corruption. For the intermediate levels there are multiple equilibria. On its consequences, corruption increases wage inequality between skilled and unskilled workers, and results in output and welfare losses. In the second essay, I argue that deterring corruption through efficiency wage may become prohibitively expensive. With endogenous monitoring technology that allows capturing the dual role of auditing, as a complement with and as a substitute for wage incentives, I find that the government is better-off accepting corruption when it is costly to monitor. When it is optimal to deter bribery, the government can do it either through efficiency wages or monitoring. The role of efficiency wages decreases in societies with higher level of dishonesty. In the third essay, I build a theory explaining a resource curse. In contrast to the existing literature which generally considers low education, corruption and natural resources separately, I combine three strands of literature. Natural resources affect incentives to invest in education and rent seeking that in turn affects growth. Second, the relationship between resource-abundance and resource-curse is non-monotonic. For low inequality in access to education and high cost of political participation, high-growth and poverty-trap equilibria co-exist
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Cantuarias-Villessuzanne, Carmen Amalia. "La mesure économique de la dépréciation du capital minier au Pérou." Thesis, Bordeaux 4, 2012. http://www.theses.fr/2012BOR40009/document.
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Le Pérou, extrêmement riche en minerais, connaît depuis les années 2000 une forte croissance économique. Àla question de savoir si sa richesse minérale condamne le Pérou à la malédiction des ressources naturelles, nousrépondons que ce n’est pas le cas à l’heure actuelle, mais nous mettons en évidence une forte dépendance vis-à-visde l’activité minière. La question centrale est celle du développement durable de l’activité minière. La mesure dela dépréciation du capital minier (dcm) est l’indicateur fondamental pour évaluer la situation. Diverses méthodesd’estimation existent, mais notre analyse microéconomique basée sur la règle de Hotelling fournit une valeurd’environ 7 % du pib sur la période 2000–2008, soit le double de l’approximation donnée par la Banque Mondiale.Nous proposons d’intégrer la dcm aux indicateurs macroéconomiques traditionnels, ce qui permet de mettreen évidence la surestimation de la croissance économique. Conformément à la règle de Hartwick, il apparaîtclairement que le développement péruvien n’est pas durable ; les revenus miniers ne compensent pas la dcmet ne sont pas réinvestis en faveur du développement du pays. Il faudrait donc taxer les entreprises minières àhauteur de la dcm, et créer un fonds de ressources naturelles. Nos résultats montrent qu’épargner seulement 8 %de la dcm permettrait d’atteindre un revenu durable pour les générations futures. La création d’un tel fonds deressources naturelles aurait également pour avantage de réduire l’instabilité macroéconomique et de promouvoirune meilleure gouvernabilitéSince the 2000s, Peru, a country extremely rich in minerals has experienced strong economic growth. WouldPeru be condemned to the resource curse because of its mineral wealth? For now this is not the case; howeverwe point up a strong dependence upon the mining sector. The main question relates to the sustainability of themining industry. The mineral depletion rate is a fundamental indicator to assess the situation. To calculate this,there are many forecasting methods available ; our microeconomic analysis based on the Hotelling rule providesa value of around 7 % of gdp for the period between 2000 and 2008, which represents double the estimation ofthe World Bank.We recommend the mineral depletion be taken into account when calculating traditional macroeconomic indicators;it would highlight the overestimation of economic growth. According to the Hartwick rule, it is clearthat Peruvian development is not sustainable; mining revenues do not offset the mineral depletion and are notreinvested in the development of the country. Therefore, the solution should be to tax mining companies at alevel equivalent to that of depletion and, with the new income, to create a natural resource fund. Saving only8 % of the mineral depletion would suffice to generate sustainable rent for futures generations. In addition, thecreation of a natural resource fund would reduce macroeconomic instability and enforce better governance
Books on the topic "Rest cure"
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1937-, Walberg Herbert J., URF Education Foundation, Heartland Institute (Chicago, Ill.), and Illinois Council on Democratic Policy., eds. We can rescue our children: The cure for Chicago's public school crisis, with lessons for the rest of America. Chicago, Ill: URF Education Foundation, 1988.
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Pouliot, Martin. Cuire ce qu'il nous reste. Trois-Rivières, Québec, Canada: Ecrits des Forges, 2001.
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New York (State). Dept. of Law. Abrams urges lawmakers to curb excessive charges for late rents. [Albany?, NY]: Dept. of Law, 1987.
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Angle, Robby. Cure for Groups: How to Lead a Group People Will Remember the Rest of Their Lives. Trueface, 2021.
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Domenig, Stephan. Alkaline Cure: Lose Weight, Gain Energy, Feel Young and Stay Healthy for the Rest of Your Life. Harlequin Enterprises, Limited, 2014.
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Angle, Robby. Cure for Small Groups: How to Lead a Group People Will Remember the Rest of Their Lives. Perichoresis Press, 2021.
Find full textBook chapters on the topic "Rest cure"
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Gregory, Fiona. "Performing the rest cure." In Actresses and Mental Illness, 18–37. London ; New York : Routledge, 2019.: Routledge, 2018. http://dx.doi.org/10.4324/9781351035507-2.
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Varanasi, Balaji, and Sudha Belida. "Installing cURL on Windows." In Spring REST, 175–77. Berkeley, CA: Apress, 2015. http://dx.doi.org/10.1007/978-1-4842-0823-6_11.
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Cieślik, Ewa. "A Ray of Hope for Central and Eastern Europe: Has the ICT Service Sector Become a Cure for Lagging Behind the Rest of EU Countries in Global Value Chains?" In European Perspectives on Innovation Management, 459–90. Cham: Springer International Publishing, 2024. http://dx.doi.org/10.1007/978-3-031-41796-2_17.
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Mehlum, Halvor, Karl Moene, and Ragnar Torvik. "Institutions and the Resource Curse." In 40 Years of Research on Rent Seeking 2, 245–64. Berlin, Heidelberg: Springer Berlin Heidelberg, 2006. http://dx.doi.org/10.1007/978-3-540-79247-5_13.
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da Silva, Clay Palmeira, Nizar Messai, Yacine Sam, and Thomas Devogele. "CUBE System: A REST and RESTful Based Platform for Liquid Software Approaches." In Lecture Notes in Business Information Processing, 115–31. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-93527-0_6.
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Jones, Roger D., and Alan M. Jones. "A Proposed Mechanism for in vivo Programming Transmembrane Receptors." In Communications in Computer and Information Science, 123–37. Cham: Springer Nature Switzerland, 2024. http://dx.doi.org/10.1007/978-3-031-57430-6_11.
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AbstractTransmembrane G-protein coupled receptors (GPCRs) are ideal drug targets because they resemble, in function, molecular microprocessors for which outcomes (e.g. disease pathways) can be controlled by inputs (extracellular ligands). The inputs here are ligands in the extracellular fluid and possibly chemical signals from other sources in the cellular environment that modify the states of molecular switches, such as phosphorylation sites, on the intracellular domains of the receptor. Like in an engineered microprocessor, these inputs control the configuration of output switch states that control the generation of downstream responses to the inputs.Many diseases with heterogeneous prognoses including, for example, cancer and diabetic kidney disease, require precise individualized treatment. The success of precision medicine to treat and cure disease is through its ability to alter the microprocessor outputs in a manner to improve disease outcomes. We previously established ab initio a model based on maximal information transmission and rate of entropy production that agrees with experimental data on GPCR performance and provides insight into the GPCR process. We use this model to suggest new and possibly more precise ways to target GPCRs with potential new drugs.We find, within the context of the model, that responses downstream of the GPCRs can be controlled, in part, by drug ligand concentration, not just whether the ligand is bound to the receptor. Specifically, the GPCRs encode the maximum ligand concentration the GPCR experiences in the number of active phosphorylation or other switch sites on the intracellular domains of the GPCR. This process generates a memory in the GPCR of the maximum ligand concentration seen by the GPCR. Each configuration of switch sites can generate a distinct downstream response bias. This implies that cellular response to a ligand may be programmable by controlling drug concentration. The model addresses the observation paradox that the amount of information appearing in the intracellular region is greater than amount of information stored in whether the ligand binds to the receptor. This study suggests that at least some of the missing information can be generated by the ligand concentration. We show the model is consistent with assay and information-flow experiments.In contrast to the current view of switch behavior in GPCR signaling, we find that switches exist in three distinct states: inactive (neither off nor on), actively on, or actively off. Unlike the inactive state, the active state supports a chemical flux of receptor configurations through the switch, even when the switch state is actively off. Switches are activated one at a time as ligand concentration reaches threshold values and does not reset because the ligand concentration drops below the thresholds. These results have clinical relevance. Treatment with drugs that target GPCR-mediated pathways can have increased precision for outputs by controlling switch configurations. The model suggests that, to see the full response spectrum, fully native receptors should be used in assay experiments rather than chimera receptors.Inactive states allow the possibility for novel adaptations. This expands the search space for natural selection beyond the space determined by pre-specified active switches.
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HINCHLIFF, PETER. "The Rest Cure." In Frederick Temple, Archbishop of Canterbury, 254–80. Oxford University Press, 1998. http://dx.doi.org/10.1093/acprof:oso/9780198263869.003.0010.
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"Spa Towns: The Rest Cure." In Healing Waters, 65–94. Routledge, 2016. http://dx.doi.org/10.4324/9781315586304-8.
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"4. Painting as Rest Cure." In Inventing the Modern Artist: Art and Culture in Gilded Age America. Yale University Press, 1999. http://dx.doi.org/10.37862/aaeportal.00068.007.
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"5. A Rest Cure in a Canoe." In Wild Things. Toronto: University of Toronto Press, 1995. http://dx.doi.org/10.3138/9781442683495-006.
Full textConference papers on the topic "Rest cure"
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Ly, Khoi, Aimee Cloutier, and James Yang. "Quantitative Motor Assessment, Detection, and Suppression of Parkinson’s Disease Hand Tremor: A Literature Review." In ASME 2016 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. American Society of Mechanical Engineers, 2016. http://dx.doi.org/10.1115/detc2016-59095.
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Parkinson’s disease (PD) is difficult to detect before the onset of symptoms; further, PD symptoms share characteristics with symptoms of other diseases, making diagnosis of PD a challenging task. Without proper diagnosis and treatment, PD symptoms including tremor, bradykinesia, and cognitive problems deteriorate quickly into patients’ late life. Among them, the most distinguishable manifestations of PD are rest and postural tremor. Tremor is defined as an involuntary shaking or quivering movement of the hands or feet. Unified Parkinson’s Disease Rating Scale (UPDRS), Hoehn and Yahr (H&Y) scales are the most common rating scales that quantify the severity of PD. Due to the lack of consistency in these diagnostic tests, researchers are looking for devices for quantification and detection that can provide more objective PD motor assessments. Additionally, since there is currently no cure for PD, temporary PD symptom suppression is an active research area for improving patients’ quality of life. In this survey, the current state of research on Parkinson’s disease hand tremor quantification, detection, and suppression is discussed, especially focusing on electromechanical devices. The future direction of research on these devices is also considered.
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Soliman, Nada Hossam, Ahmed T. M. Aboughalia, Tawanda Chivese, Omran A. H. Musa, George Hindy, Noor Al-Wattary, Saifeddin Moh'd Badran, et al. "A Meta-Review of Meta-Analyses and an Updated Meta-Analysis on the Efficacy of Chloroquine and Hydroxychloroquine in treating COVID-19 Infection." In Qatar University Annual Research Forum & Exhibition. Qatar University Press, 2020. http://dx.doi.org/10.29117/quarfe.2020.0308.
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Objective: To synthesize the findings presented in systematic reviews and meta-analyses as well as to update the evidence using a meta-analysis in evaluating the efficacy and safety of CQ and HCQ with or without Azithromycin for the treatment of COVID-19 infection. Methods: The design of this meta-review followed the preferred reporting items for overviews of systematic reviews including harms checklist (PRIO-harms). A comprehensive search included several electronic databases in identifying all systematic reviews and meta-analyses as well as experimental studies which investigated the efficacy and safety of CQ, HCQ with or without antibiotics as COVID-19 treatment. Findings from the systematic reviews and metaanalyses were reported using a structured summary including tables and forest plots. The updated metaanalyses of experimental studies was carried out using the distributional assumption-free quality effects model. Risk of bias was assessed using the assessing the methodological quality of systematic reviews (AMSTAR) tool for reviews and the methodological standard for epidemiological research (MASTER) scale for the experimental studies. The main outcome for both the meta-review and the updated metaanalyses was mortality. Secondary outcomes included transfer to the intensive care unit (ICU) or mechanical ventilation, worsening of illness, viral clearance and the occurrence of adverse events. Results: A total of 13 reviews with 40 primary studies comprising 113,000 participants were included. Most of the primary studies were observational (n=27) and the rest were experimental studies. Two meta-analyses reported a high risk of mortality with similar ORs of 2.5 for HCQ with Azithromycin. However, four other metaanalyses reported contradictory results with two reporting a high risk of mortality and the other two reporting no significant association between HCQ with mortality. Most reviews reported that HCQ with or without Azithromycin had no significant effect on virological cure, disease exacerbation or the risk of transfer to the ICU, need for intubation or mechanical ventilation. After exclusion of studies that did not meet the eligibility criteria, the updated meta-analysis contained eight experimental studies (7 RCTs and 1 quasiexperimental trial), with a total of 5279 participants of whom 1856 were on either CQ/HCQ or combined with Azithromycin. CQ/HCQ with or without Azithromycin was significantly associated with a higher risk of adverse events. HCQ was not effective in reducing mortality transfer to the ICU, intubation or need for mechanical ventilation virological cure (RR 1.0, 95%CI 0.9-1.2, I2 =55%, n=5 studies) nor disease exacerbation (RR 1.2, 95%CI 0.3-5.0, I2 =29%, n=3 studies). Conclusion: There is conclusive evidence that CQ and HCQ, with or without Azithromycin are not effective in treating COVID-19 or its exacerbation.
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Huang, Tung-Yung, Jen-Chieh Tsao, and Chi-Wei Huang. "Arbitrary Angular Displacement of Single Flexible Arm Using Mirrored Trajectory Planning." In ASME 2010 International Mechanical Engineering Congress and Exposition. ASMEDC, 2010. http://dx.doi.org/10.1115/imece2010-38482.
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This paper aims at planning the trajectory of an arbitrary angular displacement of single flexible arm to eliminate the residual flexural vibration. Though the concept of neutral points of flexural vibration was proposed, the strategy hasn’t been really extended to arbitrary angular displacement yet. Recently, the rest-to-rest motion for arbitrary angular displacement has been successfully dealt with different schemes; however, the flexible beam’s dynamic model wasn’t used to deduce their rules. This paper proposed to use mirror phenomenon to physically interpret the coincidence of half travel and a neutral point, and thereby deduce the trajectory planning scheme based on the flexural vibration model. The symmetric T-curve velocity profile is chosen to make the approach general. Having the angular acceleration fixed in the T curve, the trajectory planning problem reduces to the duration adjustment problem of the T-curve for the desired displacement with the imposed constraint of half travel at a neutral point. The simulation results demonstrate that a properly mirrored trajectory may successfully counteract the flexural vibration even tracking is made by a simple PD controller.
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Yasar, Ozlem, Serkan Inceoglu, and Ramesh Prashad. "The Effect of Polyethylene (Glycol) Diacrylate Post-Fabrication Rest Time on Compressive Properties." In ASME 2017 12th International Manufacturing Science and Engineering Conference collocated with the JSME/ASME 2017 6th International Conference on Materials and Processing. American Society of Mechanical Engineers, 2017. http://dx.doi.org/10.1115/msec2017-2809.
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In recent years, tissue engineering has been utilized as an alternative approach for the organ transplantation. The success rate of tissue regeneration is influenced by the type of biomaterials, cell sources, growth factors and scaffold fabrication techniques used. The poly(ethylene glycol) diacrylate (PEGDA) is one of commonly used biomaterials because of its biocompatibility, ease of use, and porous microstructure. The mechanical properties of PEGDA have been studied to some extent by several research groups. However, the stability of the mechanical properties with time has not been investigated. In this research, we studied how the mechanical properties of different concentrations of PEGDA change with the post-fabrication ageing time. Cylindrical PEGDA samples were prepared 20%, 40%, 60%, 80%, and 100% concentrations and cured under the UV light. After the solidification process, weight of each sample was monitored in every 0, 2, 4, 6, and 24 hours post-fabrication ageing time until the mechanical testing. Compressive elastic modulus and strength were calculated and statistically analyzed. Our results indicated that the water content of each PEGDA group constantly decreased by time, however, this loss significantly affected the elastic modulus and strength only after 6 hours in some PEGDA concentration.
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Tolstaya, Ekaterina, and Anton Egorov. "Segmentation of Seismic Images." In 31th International Conference on Computer Graphics and Vision. Keldysh Institute of Applied Mathematics, 2021. http://dx.doi.org/10.20948/graphicon-2021-3027-564-570.
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In this paper we propose a method of seismic facies labeling. Given the three-dimensional image cube of seismic sounding data, labeled by a geologist, we first train on the part of the cube, then we propagate labels to the rest of the cube. We use open-source fully annotated 3D geological model of the Netherlands F3 Block. We apply state-of-the-art deep network architecture, adding on top a 3D fully connected conditional random field (CRF) layer. This allows to get smoother labels on data cube cross-sections. Pseudo labeling technique is used to overcome training data scarcity and predict more reliable labels for geological units. Additional data augmentation allows also to enlarge training dataset. The results show superior network performance over existing baseline mode.
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Jing Bai, Shiqi Lu, Jian Liu, and Yuhong Wang. "Research on snubber circuit for high-power IGCT Based On Cur Rent Source Inverter." In 2013 International Conference on Mechatronic Sciences, Electric Engineering and Computer (MEC). IEEE, 2013. http://dx.doi.org/10.1109/mec.2013.6885568.
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Song, Weigang, Bangchun Wen, and Huijuan Liu. "Simulation Research on Dynamics of Belt Conveyor System." In ASME 2006 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. ASMEDC, 2006. http://dx.doi.org/10.1115/detc2006-99024.
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With the magnification of the belt conveyor, dynamic analysis and dynamic design have become indispensability means in the design of belt conveyor. In this article, we build the finite-element model of the starting and stopping process, which bases on the multi-driving belt conveyor system, and the dynamic calculation method of multi-driving system basing on power tracing. According to the reasonable starting curve, we start the first driving/drive, and then the rest drives trace the first driving in order. We bring forward the starting curve of trapezium acceleration from the existing S-curve. We develop the dynamic analysis software of belt conveyor and test the correctness of its calculation and software by the computer simulation of the actual system. The method had been applied in the system design of 7.6 km belt conveyor in Jincheng city, Shanxi province.
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Moscoso - Montenegro, David, and Luis Serpa-Andrade. "Interactive Die as an Educational Tool for Children with Special Educational Needs." In 13th International Conference on Applied Human Factors and Ergonomics (AHFE 2022). AHFE International, 2022. http://dx.doi.org/10.54941/ahfe1001886.
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The die as we know is a small, throwable object with marked sides that can rest in multiple positions. Although there’s variations, the most common form of die is a cube with dots marked on each side with the aim of generating random numbers in tabletop games. This notion can be extended to the pedagogic field making use of recent technologies in connected embedded systems. This article presents the design and proof of concept of an interactive die as an educational tool for children with SEN. The die consists of a RGB LED matrix for each of its six sides so it can display any kind of low-resolution symbols like numbers, letters, arrows or multicolor patterns presented in the form of animations, additionally includes an IMU to obtain the cube orientation and user tap detection when selecting the presented option on top side, audible and haptic feedback
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Zhang, Chuankun, Peng Li, Jie Jiang, Lars von der Wense, Martin E. Fermann, and Jun Ye. "A Tunable VUV Frequency Comb for 229mTh Nuclear Spectroscopy." In CLEO: QELS_Fundamental Science. Washington, D.C.: Optica Publishing Group, 2022. http://dx.doi.org/10.1364/cleo_qels.2022.fw4j.6.
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We developed a tunable vacuum-ultraviolet frequency comb via cavity-enhanced 7th-harmonic generation. Its tunable spectrum covers a large fraction of the cur-rent 229 m Th nuclear clock transition uncertainty range.
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Sun, Chongren, and Siby Samuel. "Micro scenarios – A Theory-based Intervention to Alleviate Simulator Sickness for Older Drivers in Driving Simulators." In 13th International Conference on Applied Human Factors and Ergonomics (AHFE 2022). AHFE International, 2022. http://dx.doi.org/10.54941/ahfe1002479.
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Driving continues to be the fundamental way for people to transit in North America. For older adults with physical or cognitive comorbidities, automobiles remain the most suitable method to increase mobility, independence, and quality of life. However, research shows that elderly drivers are more likely to be involved in traffic accidents. For instance, drivers over 65 are overrepresented in crashes at signalized and unsignalized four-way intersections. Driving simulator-based training interventions are a safe way for training elderly drivers, particularly on effective ways to negotiate intersections. However, driving simulators result in simulator sickness or simulation adaptation syndrome (SAS). SAS can cause nausea, disorientation, vertigo, vomiting, and sickness in humans. The adverse effects of SAS are more pronounced in older drivers over 65 compared to their younger counterparts. Studies show that the dropout rates for older drivers from simulation experiments are much higher than those for younger or middle-aged drivers. Evidence from literature largely corresponds to the Motion Cue Conflict theory by Reason and Brand. It posits that the precipitating factor for SAS is the disconnect between the participants’ visual system (in motion) and their vestibular system (stationary). Several other theories may potentially explain the occurrence of SAS, such as Poison theory, the Postural Instability theory, and the Rest-frame Theory. Treisman’s Poison theory is an evolutionary theory that identifies nausea as a natural body response to complex symptoms that resemble poisoning. Riccio and Stoffgren’s postural instability theory offers an ecology-based perspective where our action and perception systems continually attempt to maintain postural stability in our environment. According to this theory, participants get sick trying to maintain stability in a new or unfamiliar environment, such as a driving simulator. Lastly, Prothero’s rest-frame theory identifies conflicting rest-frames instead of conflicting cues as the precipitator for SAS. Across the four theories, the amount of visual flow in the simulator and the time participants spend in a simulator are the common factors potentiating SAS. To alleviate SAS, several methods and approaches have been developed and evaluated. These include galvanized vestibular stimulations, galvanic cutaneous stimulation, appropriate visual background manipulations, virtual guiding avatars, and the use of alternative sensory conditions. However, none of the above interventions have improved older driver secondary glance behavior. The current paper proposes a novel methodological approach - micro scenarios, which can effectively reduce optical flow to target older driver SAS problems, especially in scenarios involving the negotiation of left turns at intersections. Micro scenarios specifically aim to decrease the total exposure time and increase the frequency of rest breaks while striving to retain the effectiveness of the training itself. Microscenarios are driven by the Postural Instability theory and the Motion cue conflict theory. Simulator-based evaluations of micro scenarios produced very low dropout rates, and participants reported very low levels of simulator sickness compared to typical scenarios. Practitioners may use these findings to train and assess at-risk populations on driving simulators.
Reports on the topic "Rest cure"
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Asquith, Brian J. Rent Control - Is the Cure Worse Than the Disease? W.E. Upjohn Institute, August 2019. http://dx.doi.org/10.17848/pb2019-15.
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Zilberman, Mark. An Adjustment of the Apparent Luminosity of Standard Candles for the 'De-boosting' Effect. Intellectual Archive, February 2022. http://dx.doi.org/10.32370/iaj.2639.
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“De-boosting” is a well-known relativistic effect that alters the apparent luminosity of radiation sources with the non-zero redshift parameter z. It exists in both Special Relativity and General Relativity frameworks and is proportional to (z+1)^(-2). While the “boosting” (for blueshift) and “de-boosting” (for redshift) of light sources has been successfully accounted for and observed in research of various astronomical objects, it was ignored in the establishment of Standard candles for cosmological distances. A Standard candle adjustment appears necessary for “de-boosting” for high z, otherwise we would incorrectly assume that Standard candles appear dimmer, not because of “de-boosting” but because of the excessive distance, which would affect the entire Standard candles ladder at cosmological distances. The “de-boosting” correction of the apparent luminosities of SNIa places the effective rest-frame magnitudes below the curve corresponding to the cosmological model with the parameters Λ=0 and (ΩM, ΩΛ) = (2, 0) on the Hubble diagram. This way, the “de-boosting” correction of the apparent luminosities of SNIa may further adjust and clarify cosmological models.
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Oliveira, Déborah, Santiago León-Moncada, and Francisco Terra. El uso de Baremos de Valoración de la Funcionalidad y de la Dependencia de cuidados en personas mayores: Prácticas, avances y direcciones futuras. Inter-American Development Bank, June 2022. http://dx.doi.org/10.18235/0004280.
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El aumento creciente en el número de personas mayores y en la prevalencia de enfermedades crónicas a nivel mundial ha determinado un cambio en el enfoque de los sistemas de atención, de cura y tratamiento de enfermedades, hacia un mayor enfoque en la gestión de las condiciones de salud. Este cambio busca promover la calidad de vida de las personas mayores a través de la mejora en la funcionalidad, aunque en el contexto de una o múltiples condiciones de salud. Esto ha generado algunos desafíos prácticos y metodológicos con respecto a las mejores formas de conceptualizar, evaluar y gestionar (mantener, restaurar u optimizar) la funcionalidad y la necesidad de cuidados con el fin de brindar servicios y apoyos adecuados y oportunos a las personas mayores en situación de dependencia temporal o permanente de cuidados. En América Latina y en algunos países europeos se ha adoptado el uso de baremos para la evaluación de la funcionalidad y las necesidades de ayuda para realizar las tareas de la vida diaria, incluyendo a población con, o en riesgo de, deterioro funcional. Esta evaluación puede ser usada para informar tanto las decisiones gubernamentales sobre la oferta de servicios de atención de largo plazo a nivel agregado, como la oferta de servicios a cada persona. Sin embargo, la implementación de baremos en la región es muy reciente y resta mucho por conocer acerca de su capacidad para evaluar y clasificar las especificidades relacionadas a la funcionalidad de las personas mayores, así como para direccionar con efectividad la oferta de servicios de cuidados a esta población. El objetivo de esta nota técnica es brindar una visión general sobre el estado actual del desarrollo y aplicación de baremos en América Latina y en países europeos buscando proporcionar a los gobiernos elementos para desarrollar o mejorar sus sistemas de evaluación de funcionalidad y necesidad de cuidados entre las personas mayores, y con ello avanzar en el desarrollo de sus sistemas de cuidados de larga duración a esta población
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Anderson, Gerald L., and Kalman Peleg. Precision Cropping by Remotely Sensed Prorotype Plots and Calibration in the Complex Domain. United States Department of Agriculture, December 2002. http://dx.doi.org/10.32747/2002.7585193.bard.
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This research report describes a methodology whereby multi-spectral and hyperspectral imagery from remote sensing, is used for deriving predicted field maps of selected plant growth attributes which are required for precision cropping. A major task in precision cropping is to establish areas of the field that differ from the rest of the field and share a common characteristic. Yield distribution f maps can be prepared by yield monitors, which are available for some harvester types. Other field attributes of interest in precision cropping, e.g. soil properties, leaf Nitrate, biomass etc. are obtained by manual sampling of the filed in a grid pattern. Maps of various field attributes are then prepared from these samples by the "Inverse Distance" interpolation method or by Kriging. An improved interpolation method was developed which is based on minimizing the overall curvature of the resulting map. Such maps are the ground truth reference, used for training the algorithm that generates the predicted field maps from remote sensing imagery. Both the reference and the predicted maps are stratified into "Prototype Plots", e.g. 15xl5 blocks of 2m pixels whereby the block size is 30x30m. This averaging reduces the datasets to manageable size and significantly improves the typically poor repeatability of remote sensing imaging systems. In the first two years of the project we used the Normalized Difference Vegetation Index (NDVI), for generating predicted yield maps of sugar beets and com. The NDVI was computed from image cubes of three spectral bands, generated by an optically filtered three camera video imaging system. A two dimensional FFT based regression model Y=f(X), was used wherein Y was the reference map and X=NDVI was the predictor. The FFT regression method applies the "Wavelet Based", "Pixel Block" and "Image Rotation" transforms to the reference and remote images, prior to the Fast - Fourier Transform (FFT) Regression method with the "Phase Lock" option. A complex domain based map Yfft is derived by least squares minimization between the amplitude matrices of X and Y, via the 2D FFT. For one time predictions, the phase matrix of Y is combined with the amplitude matrix ofYfft, whereby an improved predicted map Yplock is formed. Usually, the residuals of Y plock versus Y are about half of the values of Yfft versus Y. For long term predictions, the phase matrix of a "field mask" is combined with the amplitude matrices of the reference image Y and the predicted image Yfft. The field mask is a binary image of a pre-selected region of interest in X and Y. The resultant maps Ypref and Ypred aremodified versions of Y and Yfft respectively. The residuals of Ypred versus Ypref are even lower than the residuals of Yplock versus Y. The maps, Ypref and Ypred represent a close consensus of two independent imaging methods which "view" the same target. In the last two years of the project our remote sensing capability was expanded by addition of a CASI II airborne hyperspectral imaging system and an ASD hyperspectral radiometer. Unfortunately, the cross-noice and poor repeatability problem we had in multi-spectral imaging was exasperated in hyperspectral imaging. We have been able to overcome this problem by over-flying each field twice in rapid succession and developing the Repeatability Index (RI). The RI quantifies the repeatability of each spectral band in the hyperspectral image cube. Thereby, it is possible to select the bands of higher repeatability for inclusion in the prediction model while bands of low repeatability are excluded. Further segregation of high and low repeatability bands takes place in the prediction model algorithm, which is based on a combination of a "Genetic Algorithm" and Partial Least Squares", (PLS-GA). In summary, modus operandi was developed, for deriving important plant growth attribute maps (yield, leaf nitrate, biomass and sugar percent in beets), from remote sensing imagery, with sufficient accuracy for precision cropping applications. This achievement is remarkable, given the inherently high cross-noice between the reference and remote imagery as well as the highly non-repeatable nature of remote sensing systems. The above methodologies may be readily adopted by commercial companies, which specialize in proving remotely sensed data to farmers.
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Arumugam, Udayansankar, Mimoun Elboujdaini, Ming Gao, and Ramiro Vanoye. PR-328-133702-R02 F-S Fatigue Testing of Crack-in-Dent with Framework for Life Prediction. Chantilly, Virginia: Pipeline Research Council International, Inc. (PRCI), October 2019. http://dx.doi.org/10.55274/r0011628.
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ASME B31.8 states that "Dents that contain stress corrosion cracking or other cracks are injurious to the pipeline" and therefore, requires immediate attention by the Operators. Dent containing crack fields (colonies) are often observed in liquid pipelines. The recently completed PRCI research project MD-1N "Study of the Mechanism for Cracking in Dents in a Crude Oil Pipeline" showed evidence of a mechanism for fatigue cracking. The crack growth rate as a function of stress intensity factor was estimated using the measured spacings of fatigue striations from fracture surfaces based on the assumption that the formation of fatigue striations on a cycle-by-cycle basis. However, due to the lack of full-scale fatigue crack growth data, the success was limited. This gap prompted PRCI to launch a full-scale experimental investigation of crack growth rates of cracks in dents under cyclic pressure load in the simulated groundwater NS4 environment (PRC-328-133702, MD-1Q). The objective of the study was to determine the crack growth rate as a function of stress intensity factor, the number of cycles to failure, and the failure modes of cracks in dents. The test results would be used to evaluate the validity of cycle-by-cycle based assumption for crack growth rate estimation from the measured fatigue-striation-spacing. The investigation was also aimed at establishing a framework for remaining fatigue life prediction of cracks in dents in liquid pipelines. This framework would benefit liquid pipeline Operators to manage better the integrity of dents associated with corrosion fatigue cracking in groundwater. A total of six pipe samples containing cracks in shallow dents excavated from a retired 24-inch diameter liquid transmission pipeline were available and used for the full-scale fatigue tests. The test system developed under the project consisted of four components: (1) a computer-controlled hydraulic pressure cycling system, (2) an environment chamber containing a simulated groundwater NS4 solution mounted on the pipe in around the dent region to provide a simulated field environment condition; (3) real-time crack growth monitoring systems including direct cur-rent potential drop (DCPD), Clip gage and Strain gage; (4) data acquisition system. The cyclic pressure range used in the fatigue tests was 78 to 780 psig (72%SMYS) with R=0.1, which was based on historical operational pressure data and the Rain flow analysis. A constant frequency of 0.0526 Hz was selected for the testing to ensure the frequency requirement for corrosion fatigue is met. The remaining fatigue life of cracks-in-dents and failure modes were evaluated using the full-scale fatigue test results. Further, fatigue crack growth rates were established. Finally, a framework was developed for the life prediction of cracks in shallow dents based on the findings from six full-scale fatigue cyclic tests. This framework will assist liquid pipeline operators to estimate the remaining fatigue life for cracks in shallow dents utilizing inputs from ILI and pipeline's historical operational pressure fluctuation data and to mitigate the threat of cracks in dents in a timely manner. There is a related webinar.