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1
Sharpe, M., and S. Wessely. "Putting the rest cure to rest---again." BMJ 316, no. 7134 (March 14, 1998): 796–800. http://dx.doi.org/10.1136/bmj.316.7134.796.
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Blackie, Michael. "Reading the Rest Cure." Arizona Quarterly: A Journal of American Literature, Culture, and Theory 60, no. 2 (2004): 57–85. http://dx.doi.org/10.1353/arq.2004.0012.
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Martin, Diana. "The Rest Cure Revisited." American Journal of Psychiatry 164, no. 5 (May 2007): 737–38. http://dx.doi.org/10.1176/ajp.2007.164.5.737.
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Pearce, J. M. S. "Silas Weir Mitchell and the "rest cure"." Journal of Neurology, Neurosurgery & Psychiatry 75, no. 3 (March 1, 2004): 381. http://dx.doi.org/10.1136/jnnp.2002.002386.
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Passmore, Gayle, and Patrick Delmas. "Does cure for pain REST on Kv7 channels?" Pain 152, no. 4 (April 2011): 709–10. http://dx.doi.org/10.1016/j.pain.2011.02.040.
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Gregory, Fiona. "Performing the Rest Cure: Mrs Patrick Campbell's Ophelia, 1897." New Theatre Quarterly 28, no. 2 (May 2012): 107–21. http://dx.doi.org/10.1017/s0266464x12000218.
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In 1897 audiences welcomed Johnston Forbes-Robertson's new interpretation of Hamlet to the London stage, and his sane, intelligent Prince was received as an exciting departure from tradition. Mrs Patrick Campbell's own experiments with the role of Ophelia in this production were not so warmly greeted, critics describing her playing as ‘curiously weak’ and ‘unconvincing and unimpressive’. Campbell had rejected the conventional model of the character as emblematic of the prettiness and pathos exemplified by Ellen Terry, and instead offered a vacant, depressive, ‘beaten’ Ophelia. In this article, Fiona Gregory examines the influences behind this choice, including the actress's own experience of mental illness and the notorious ‘rest cure’. The reception of the performance is read in terms of contemporary attitudes to Ophelia and mental illness, as well as of responses to Campbell and her celebrity identity in the visual arts. Ultimately, Campbell's performance of Ophelia can be read as a ‘witness account’ of neurasthenia and the ‘rest cure’, to stand alongside texts such as Charlotte Perkins Gilman's story ‘The Yellow Wallpaper’. Fiona Gregory lectures in the Centre for Theatre and Performance at Monash University, and has published work on the career of actress Judith Anderson, Australian cultural history, and Victorian and Edwardian writers. She is currently undertaking a wide-ranging study of actresses and mental illness from the nineteenth century to the present day, drawing on historical examples and literary and cultural representations to consider the intersections of ‘hysteria’ and the ‘histrionic’.
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Bassuk, Ellen L. "The Rest Cure: Repetition or Resolution of Victorian Women's Conflicts?" Poetics Today 6, no. 1/2 (1985): 245. http://dx.doi.org/10.2307/1772132.
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Andrada Hamer, Maria, and Jan Persson. "Preoperative urethral parameters at rest and objective cure following laparoscopic colposuspension." International Urogynecology Journal 21, no. 3 (November 19, 2009): 331–36. http://dx.doi.org/10.1007/s00192-009-1034-3.
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Kolisko, Petr, Milada Sárová, Michele Oliviano, Jakub Krejčí, and Petr Uhlíř. "Influence of carlsbad thermo-mineral water on the autonomic nervous system." Acta Salus Vitae 12, no. 1 (July 11, 2024): 13–21. http://dx.doi.org/10.58743/asv2024vol12no1.334.
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The drinking cure is an essential part of Karlovy Vary spa treatment. The effect of Karlovy Vary mineral water on the autonomic nervous system has not yet been investigated. Based on case analyses, we hypothesized that the effects of the drinking cure have an effect on the functional activity of the autonomic nervous system. The prospective research study had the character of an experiment in clinical conditions. Research file: Health women n = 15, age 40-50 years. Methodology: Before and 30 min after the experimental sequence, the functional state of the autonomic nervous system was examined by the method of spectral analysis of heart rate variability in the ortho-clino-orthostatic position. The experimental sequence: rest sitting position (pre) drinking cure in a sitting position (application of 350 ml thermo-mineral water 50 °C) rest sitting position (post). The length of all monitored intervals was 300 heartbeats. Results: Pre-post status (30–50 minutes after the application of the drinking cure): an increase in the overall activity of the autonomic nervous system an increase in activity in the sympathetic and parasympathetic frequency bands reducing the heart rate blood pressure values did not change. Effects during the application of the drinking cure (comparison with a rest sitting position): a decrease in the overall activity of the autonomic nervous system an increase in sympathetic activity and decrease in parasympathetic activity an increase in heart rate an increase in systolic and diastolic blood pressure. Conclusions: A prospective research study highlighted the reflexive relationships between the digestive system and the cardiovascular system. These relationships are modulated by the autonomic nervous system. Factors that influence the effect of the drinking cure in the area of the upper part of the digestive system are: the rhythm of swallowing and the temperature of the water. Factors that influence the post-effect of the drinking cure in the area of the duodenum and jejunum they probably are: high content of free carbon dioxide and bicarbonate ions in the Carls Bad thermomineral water. These factors apparently activate the motility of the intestinal tract and have an effect on systemic changes of the functional status of the autonomic nervous system.
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Kelly, Lori Duin. "Selecting a Somatic Type: The Role of Anorexia in the Rest Cure." Journal of Medical Humanities 33, no. 1 (November 24, 2011): 15–26. http://dx.doi.org/10.1007/s10912-011-9164-2.
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Stiles, Anne. "Christian Science versus the Rest Cure in Frances Hodgson Burnett’s The Secret Garden." MFS Modern Fiction Studies 61, no. 2 (2015): 295–319. http://dx.doi.org/10.1353/mfs.2015.0024.
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Ammari, Deema. "Bed Rest' Challenged: A Liberating Treatment in 'The Yellow Wallpaper'." International Journal of Arabic-English Studies 15, no. 1 (January 1, 2014): 27–38. http://dx.doi.org/10.33806/ijaes2000.15.1.2.
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This article explores a feminist approach to the nineteenth century psychoanalytical treatment of 'Bed Rest'. The treatment, as the article demonstrates, is practiced on women who according to standards of patriarchal society project abnormal brain activity, and should be reduced to docility in order for them to resume their domestic societal roles. However, the cure in this research does indeed prove to be beneficial for women by giving the opposite of the intended outcome, by allowing women enough space to question their place in society and allocate a subjective Self that goes beyond the fixed patriarchal image of maleness and femaleness onto a fluid 'in-between'. This newly formed individuality will be discussed through the analysis of Charlotte Perkins Gilman's short story 'The Yellow Wallpaper'..
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Cervetti, Nancy. "S. Weir Mitchell Representing "a hell of pain": From Civil War to Rest Cure." Arizona Quarterly: A Journal of American Literature, Culture, and Theory 59, no. 3 (2003): 69–96. http://dx.doi.org/10.1353/arq.2003.0001.
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Gräf, Charlotte M., Tomas Kupec, Elmar Stickeler, Tamme W. Goecke, Ivo Meinhold-Heerlein, and Laila Najjari. "Tomographic Ultrasound Imaging to Control the Placement of Tension-Free Transobturator Tape in Female Urinary Stress Incontinence." BioMed Research International 2016 (2016): 1–6. http://dx.doi.org/10.1155/2016/6495858.
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Purpose. The objective was to evaluate, by means of tomographic ultrasound imaging (TUI), the reliability of a novel approach for determining the position of the implanted tension-free transobturator tape (TOT). Furthermore, we analyzed the association between the position of the tape at rest and the subjective cure in stress incontinent women.Methods. This retrospective pilot study consists of 32 stress incontinent women, who underwent TOT procedure and routine sonographic control at day 1 postoperatively and at follow-up visit. TUI was applied on the resulting 4D volumes, thereby delivering 9 axial slices with a 4 mm interslice distance starting at the meatus urethrae internus in caudal direction. The reliability of the approach was tested by two examiners. Postoperative and follow-up ultrasound parameters of uncured and cured patients were analyzed.Results. Measurements of the position of the TOT demonstrated high intraclass correlation coefficients. We found minor differences between sonographic parameters at day 1 postoperatively and at follow-up after a median period of 321 days. In cured patients, the position of the tape was measured in a more caudal position than in uncured patients.Conclusions. TUI can be a reliable method for determining the position of the tape. Further studies are needed to evaluate whether the postoperatively determined position can be used as an indicator of future subjective cure.
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SMITH, GEORGE W. "MIXING AND PHASE SEPARATION IN LIQUID CRYSTAL/MATRIX SYSTEMS." International Journal of Modern Physics B 07, no. 25 (November 15, 1993): 4187–213. http://dx.doi.org/10.1142/s0217979293003620.
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We review mixing and phase separation (demixing) in mixtures of low molecular weight liquid crystals (LCs) and organic matrices, with emphasis on aspects relevant to the formation of polymer-dispersed liquid crystal films. These films, which contain a myriad of micron-sized LC droplets, are of interest because of their electro-optic properties. Film formation is simple: A liquid crystal and a liquid polymer precursor are initially mixed to form a single phase. Subsequently the polymer is hardened, and LC microdroplets phase-separate from the matrix. Although matrix hardening can be achieved in several ways, this review focuses on curing, during which cross-linking reactions lead to an increased matrix molecular weight. Topics discussed include: phase behavior of the binary system before, during, and after cure and LC/matrix solubilities. The Flory-Huggins model for phase separation (as modified by several workers) has provided a theoretical basis for the studies. Principal experimental tools have been calorimetry and light scattering. Uncured LC/matrix binaries possess phase diagrams with an upper critical solution temperature. Such systems, when heated through the mixing temperature, exhibit a decrease in specific heat, the (negative) excess specific heat of mixing, ∆ C mix . A plot of ∆ C mix vs. LC concentration exhibits a minimum, from which we can estimate LC and uncured-matrix solubilities. Matrix cure plays a major role in the phase separation process: In partially-cured samples, ∆ C mix transitions persist until cure is nearly complete, at which time a fraction of the LC is permanently phase-separated, with the rest remaining dissolved in the matrix. The kinetics of phase separation can be determined by calorimetry or light scattering. Cure rates have been shown to control LC microdroplet size, with fast cures leading to small droplets. Calorimetry of the fully cured system also allows us to determine the solubility of liquid crystal in the polymer matrix, as well as the fraction of phase-separated LC. An approximation based on the lever rule and the Flory-Huggins spinodal curve provides an upper bound for the solubilities and also describes their temperature dependence.
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Koper, Beata. "Rest cure – XIX-wieczna terapia nudą Silasa Weira Mitchella w opowiadaniu „Żółta tapeta” Charlotte Perkins Gilman." Stan Rzeczy, no. 2(11) (November 1, 2016): 103–18. http://dx.doi.org/10.51196/srz.11.6.
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Artykuł zawiera kulturową analizę wpływu przymusowego odpoczynku od aktywności intelektualnej i domowej nałożonego na XIX-wieczne pacjentki diagnozowane jako cierpiące na neurastenię. Historia terapii Weira Mitchella Rest Cure, stworzona dla kobiet cierpiących z powodu nerwów, stanowi kontekst dla interpretacji sztandarowego opowiadania C.P. Gilman Żółta tapeta. Teoria choroby zaproponowana przez słynnego lekarza była wyraźnie skorelowana z płcią. Mimo że sam opis terapii (odpoczynek, dieta, masaże) brzmi trywialnie, to Mitchell stał się czarnym charakterem w opowiadaniu amerykańskiej prozaiczki. Tekst Gilman w metaforyczny sposób pokazuje, jak rygorystycznie zastosowana terapia nudą doprowadza narratorkę do szaleństwa. Terapia spoczynkowa pokazuje represyjne oblicze medycyny, tym samym nuda, stanowiąca główne założenie leczenia, jest nudą wręcz zabójczą. Nie ma tu miejsca na odpoczynek, postrzegany pozytywnie, pozostaje nuda, która w tym przypadku ma znaczenie wyłącznie pejoratywne.
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CONTRERAS, PATRICIO, ELENA ALTIERI, CLAUDIO LIBERMAN, ALFREDO GAC, AURISTELA ROJAS, ALVARO IBARRA, MARILLAC RAVANAL, and MARíA SERóN-FERRé. "Adrenal Rest Tumor of the Liver Causing Cushing's Syndrome: Treatment withKetoconazole preceding an Apparent Surgical Cure*." Journal of Clinical Endocrinology & Metabolism 60, no. 1 (January 1985): 21–28. http://dx.doi.org/10.1210/jcem-60-1-21.
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Dressel, Thomas D., and Christine M. Custer. "A closed-loop negative feedback model for the pancreas: A new paradigm and pathway to a cure." Medicine 103, no. 28 (July 12, 2024): e38802. http://dx.doi.org/10.1097/md.0000000000038802.
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Background and aims: To develop a model that describes how the pancreas functions, how the rate of synthesis of digestive enzymes is regulated, and finally what puts the pancreas to rest between meals. Methods: We applied the principals of control theory to previously published canine data to develop a model for how the canine pancreas functions. Using this model, we then describe the steps needed to apply this model to the human pancreas. Results: This new closed-loop negative feedback model describes what regulates digestive enzyme synthesis. This model is based on basolateral exocytosis of butyrylcholinesterase (BCHE) into the interstitial space. It is this level of BCHE * BCHE activity that controls the rate of canine pancreas digestive enzyme synthesis, and in the absence of stimulation from the vagus nerve, puts the pancreas to rest between meals. Conclusions: Finding secretagogue-specific inhibitory enzymes in the human pancreas that are analogous to BCHE in the canine, and blocking its associated receptors, may lead to a cure for human pancreatitis.
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Cheng, K. M., C. M. Chan, Y. L. Cheung, C. C. Liang, M. K. Lee, C. L. Leung, H. M. Chiu, and C. H. Chan. "Transvenous Embolisation of Spontaneous Carotid-Cavernous Fistulas by Sequential Occlusion of the Cavernous Sinus." Interventional Neuroradiology 5, no. 3 (September 1999): 225–34. http://dx.doi.org/10.1177/159101999900500305.
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There are two important pathological features associated with carotid-cavernous fistula (CCF): the retrograde cortical venous drainage that can cause intracranial haemorrhage and non haemorrhagic neurological deficit and the retrograde ophthalmic venous drainage that causes orbital venous congestion and visual impairment. We propose a sequential embolisation strategy by the selective occlusion of these two pathological features as the initial steps followed by occlusion of the rest of the cavernous sinus. Eight patients with spontaneous CCF were treated by transvenous embolisation using our embolisation strategy. The clinical features, angiographic findings, embolisation procedures, and clinical and angiographic outcomes were analyzed. The follow-up period ranged from one to 21 months. Clinical cure was achieved in six patients at one to two month follow-ups. One patient with bilateral CCFs had clinical cure of the right eye and clinical improvement of the left eye at three-month follow-up. Another patient had clinical cure at one-month follow-up except residual VI nerve palsy. Two patients had complete angiographic obliteration of the fistula immediately after the embolisation procedure. Another three patients underwent follow-up angiography at one to 16 months and all showed angiographic cure. There were no immediate or late complications. Our embolisation strategy offers a safe and effective option in the embolisation of spontaneous CCF as demonstrated by the clinical results of our eight patients.
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Öchsner-Pischel, M. "Initiator of the Open-Air Rest Cure: Peter Dettweiler and the Sanatorium at Falkenstein (Taunus) in Germany." Pneumologie 59, no. 5 (May 2005): 349–53. http://dx.doi.org/10.1055/s-2004-830217.
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Bhattacharya, Swapan K., Fei Xie, Han Wu, Kelley Hodge, Keck Pathammavong, Paul N. Houston, Daniel F. Baldwin, and Albert Giorgini. "A HIGH THROUGHPUT, LOW COST ASSEMBLY APPROACH FOR LED IMS PACKAGES TO HEAT SINK USING ADVANCED THERMAL INTERFACE MATERIALS." International Symposium on Microelectronics 2015, no. 1 (October 1, 2015): 000627–32. http://dx.doi.org/10.4071/isom-2015-tha36.
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The objective of this study is to design and fabricate a high reliability LED Insulated Metal Substrate (IMS) package to complex heat sink attachment using an advanced thermal interface material (TIM). The assembly consists of LED IMS parts bonded to a heat spreader/sink using an advanced TIM and a corner bond material to quickly and accurately secure the LEDs in position. The corner bond adhesive is snap cured for fast machine cycle times while the high performance, high adhesion TIM materials cure throughout the rest of the assembly operation. This approach allows high accuracy LED bonding without the need for alignment pins or fasteners to anchor to the IMS. The IMS attached to the heat sink is then electrically interconnected with a thin flex substrate on top of the IMS. This approach is expected to replace the current mechanical fastners and low strength silicone TIM materials and reduce the cycle time and overall placement cost which are key drivers especially for the automotive industry.
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Bargman, Howard, and Jacqueline Hochman. "Topical Treatment of Bowen's Disease with 5-Fluorouracil." Journal of Cutaneous Medicine and Surgery 7, no. 2 (March 2003): 101–5. http://dx.doi.org/10.1177/120347540300700201.
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Background: Bowen's disease is a common skin cancer. There are many different therapeutic approaches to treatment. Topical 5-Fluorouracil (5-FU) cream has been used for many years and there are many published papers attesting to its effectiveness. However, no papers have presented long-term followup results with biopsy confirmation of cure. Objectives: The purpose of this article is to present the long-term findings following the use of this cream in the treatment of Bowen's disease. Methods: Twenty-four patients with 26 biopsy-confirmed lesions of Bowen's disease were treated with topical 5-Fluorouracil cream and were followed for periods of up to 10 years. Posttreatment biopsies were performed in most cases. Results: Two of the 26 lesions treated topically recurred at some point. The rest were apparently cured. Conclusion: The results presented in this article confirm that treatment of Bowen's disease with topical 5-Fluorouracil cream is safe and effective treatment.
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Dey, A. N., S. Datta, and Bani Sharma. "Documentation of ethno-medicinal practices: A case study on tribal forest fringe dwellers of Terai West Bengal in India." Journal of Applied and Natural Science 7, no. 2 (December 1, 2015): 822–27. http://dx.doi.org/10.31018/jans.v7i2.689.
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The ethno-medicinal practices were documented which were being used by tribal population dwelling forest fringe areas of Terai zone of West Bengal, India on under exploited, non conventional, traditional and indigenous plant species for the sustainable utilization of these resources to cure day to day ailments. A total number of forty seven medicinal plant species belonging to 25 families were documented during the survey period 2012-13, which was used in curing many diseases. Among the families, Euphorbiaceae, Zingeberaceae and Leguminosae were the dominant families that represented four species each. Herb was the highest proportion of plant species 18 (38%) followed by 15 tree species (32%), 8 species of shrubs (17%) and rest were climbers and fern. It was observed that the tribal forest fringe communities of the Terai zone of the West Bengal have a good ethno-medicinal knowledge of using plant resources and developed their own traditional practices to cure day to day diseases.
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Takada, Yoshihiko, Yoshikuni Fujita, Masahiro Igarashi, Tomoe Katsumata, Haruya Okabe, Katsunori Saigenji, Toshitake Takahashi, and Eio Atari. "Intestinal Behçet’s disease—Pathognomonic changes in intramucosal lymphoid tissues and effect of a “rest cure” on intestinal lesions." Journal of Gastroenterology 32, no. 5 (September 1997): 598–604. http://dx.doi.org/10.1007/bf02934108.
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Cervetti, Nancy. "Bodies in the Archive." RBM: A Journal of Rare Books, Manuscripts, and Cultural Heritage 15, no. 2 (September 1, 2014): 124–34. http://dx.doi.org/10.5860/rbm.15.2.425.
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Off and on for fifteen years I traveled the country to research the life and work of the nineteenth-century physician S. Weir Mitchell. Mitchell is best known as the creator of the rest cure to treat hysteria and neurasthenia, but his wide-ranging interests led him to explore many other areas of medicine and literature. His groundbreaking work with rattlesnake venom earned him an international reputation, and his work with gunshot wounds, burning pain, and phantom limbs during the U.S. Civil War won him the title of the “Father of American Neurology.” Mitchell also possessed an impressive facility with language, and . . .
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Dhayagonde, Suresh Malakari, and Sayaji Desai. "AYURVEDIC MANAGEMENT OF PARIKARTIKA WSR FISSURE IN ANO : A CASE STUDY." International Journal of Research -GRANTHAALAYAH 10, no. 4 (May 16, 2022): 200–204. http://dx.doi.org/10.29121/granthaalayah.v10.i4.2022.4581.
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Nowday’s hurry and worries lifestyle give rises to Ano rectal diseases. Fissure_in_ano in one of the most common disease found in society. Constipation, burning sensation at anal region, bleeding with stool are common symptoms of fissure_in_ano. In Ayurved its can compare with parikartika.20 years old male patient suffering from guda daha, sarakta mala_prawrutti, malavshmbha, aanaha from last 10 days. With modern medicine he got temporary relief in guda daha but there is no relief in rest symptoms. For Ayurvedic treatment he came to our hospital. With first day he got relief and at the end of 5rd days he feel total cure.
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Arafah, Hasanudin. "Cupping Therapy Modern Medicine Solutions In Islam." Global International Journal of Innovative Research 2, no. 6 (June 13, 2024): 1271–78. http://dx.doi.org/10.59613/global.v2i6.214.
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Every disease has a cure, this is a form that must be done by humans so that efforts when stricken by disease. If all diseases have a cure, then easily a person will become healthy. Maintaining health is a choice for humans. Someone in maintaining their health has various ways ranging from regulating diet, exercise patterns, regulating rest periods, some are on a diet. Hijamah or cupping is a form of therapy to maintain and treat various diseases. Although in its history cupping is a treatment / therapy that has long been known, namely since the time of the Prophet Muhammad Saw. But until now there are still many people who follow it, in addition to the sunnah taught cupping is also able to provide solutions in health. Cupping is not only done when someone is sick, but can be done to maintain health by paying attention to the time arranged according to Islam. Cupping is not only doing health therapy but also carrying out the sunnah of the Prophet Muhammad (peace be upon him)
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MANTOVANI, E. "IDIOPATHIC RECURRENT CYSTITIS: A UROGYNAECOLOGICAL DILEMMA." Urogynaecologia 15, no. 3 (July 1, 2010): 29. http://dx.doi.org/10.4081/uij.2004.29.
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During the first episode of cystitis, the general tendency is to proceed directly with treatment, postponing diagnosis, precisely because it is the first episode, and due to the impressiveness of the symptoms of acute cystitis, and also in the implicit hope that it may be an isolated episode that does not repeat itself. The usual recommendation is rest, abstention from sexual activity, and a mineral water cure. Wide spectrum antiseptic, anti-inflammatory, antispasmodic drugs and painkillers are prescribed. If, despite this, and perhaps after a short period of time, the episode relapses, a diagnosis should be performed. We are consequently dealing with Recurrent Cystitis.
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Mayanih, Mayanih. "The Effect of Giving Olive Oil on the Risk of Pressure Wounds in Bedridden Patients." Journal of Complementary Nursing 2, no. 1 (February 3, 2023): 133–38. http://dx.doi.org/10.53801/jcn.v2i1.89.
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Introduction: Children who are hospitalized due to long bed rest, immobilization and attached medical devices are prone to pressure sores. Pressure sores are a problem with limited activity, these conditions can reduce the cure rate and increase the occurrence of complications and reduce the patient's quality of life. Objective: To determine the effect of giving olive oil on the risk of pressure ulcers in bedridden patients. Methods: The research design uses a quasi-experimental design. This type of research is pre-test and post-test. This research was conducted in the Children's ICU Room at Harapan Kita Cardiovascular Hospital. The time of research is June - July 2022. The sample in this study is 15 respondents with a sampling technique using Total Sampling. Data analysis with dependent T-test or Paired Sample T-test. Results: The statistical test results show that a p-value of 0.000 means P <0.05. Conclusion: There is an effect of giving olive oil on the risk of pressure ulcers in bed rest patients.
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Md. Abdulla-Hel Kafi, Mohsena Akter, Rumana Khan, Syed Shair Ahmed, Md. Jonayed Hassan, and Mohammad Shariful Hassan. "Efficacy and Safety of Voriconazole in the treatment of resistant cases of Dermatophytosis." Z H Sikder Women’s Medical College Journal 2, Number 1 (January 1, 2020): 3–6. http://dx.doi.org/10.47648/zhswmcj.2020.v0201.01.
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This is a descriptive type of longitudinal study conducted among Hundred clinically diagnosed cases of dermatophytes attending at skin out patients department of Zainul Haque Sikder Women’s Medical College, Bangladesh from August 2018 to August 2019 to observe the efficacy and safety of voriconazole among the resistant cases of dermatophytosis. Among 100 patients, 40 were males and 60 females between ages 20 and 65 years of all age group with clinical, mycological diagnosis of dermatophytosis. To find out antifungal resistance pattern as well as efficacy and Safety of Voriconazole among dermatophytes. (Skin, hair and nail samples were taken aseptically. All patients were resistant against present treatment options like: fluconazole, itraconazole & terbinafine etc.) All patients were treated with Voriconazole. Duration of treatment of each patient was 4 weeks. Resistance against fluconazole and terbinafine was most common, 85.33% and 58% respectively. 5% resistance against voriconazole was observed in this study. Resistance against fluconazole was noted among all species of dermatophytes, followed by terbinafine. Among 100 patients 80% was fully cure and rest of 15 % were partially cure with 5% resistant of Voriconazole which is seems to be more effective and safer against dermatophytosis.
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Matin, Abdul, Md Rafiqul Islam, Ranjit Ranjan Roy, Bijoy Krishna Das, Sudesh Chandra Rakshit, and Rita Khan. "Management of congential muscular toticollis under one year of age." Journal of Shaheed Suhrawardy Medical College 1, no. 2 (October 14, 2012): 2–5. http://dx.doi.org/10.3329/jssmc.v1i2.12157.
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Background and study aim: Torticollis is the postural deformity of head and neck. Congenital Muscular Torticollis (CMT) is a postural deformity of head and neck detected at birth or shortly after birth, primarily resulting from unilateral shortening of Sternocleidomastoid muscle (SCM), In neonates and infants, patient may cure conservatively by physiotherapy but surgery is the treatment of choice for children and adolescents. Here we show our experience regarding management of congenital muscular torticollis with physiotherapy. Patients and Methods: This is an observational descriptive study. Verbal consent from parents was taken. Patients of congenital muscular torticollis with other disease or other congenital anomaly were excluded from study. Twenty patients of congenital muscular torticollis were treated. The cases were enrolled between Nov' 2005 to Oct' 2008 in Bangabandhu Sheikh Mujib Medical University, Gonosasthaya Somaj Vittik Medical College Hospital, ZH Sikder Women's Medical College Hospital, Shaheed Shurawardy Medical College Hospital. Neonates and infants were treated conservatively with physiotherapy and non responsive cases were referred for surgery. Results: Patients age range from 5 days to 1 year of which eleven were females and nine were males. Sternocleidomastoid muscle (SCM) was shortened in all cases (12 on right side and 8 on left side). Of 20 patients 6 neonates, rest 14 infants within 1 year age. Out of 20 neonates and infants 17 were cured conservatively with physiotherapy and rest 3 were referred for surgery. Conclusion: Most of the patient of congenital muscular torticollis can be treated conservatively during infancy. DOI: http://dx.doi.org/10.3329/jssmc.v1i2.12157 Journal of Shaheed Suhrawardy Medical College Vol.1, No.2, December 2009 p.2-5
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Fisher, A. "A case of radical cure of posterior uterus inflection by ventrotixatio surgery." Journal of obstetrics and women's diseases 5, no. 5 (August 7, 2020): 475–76. http://dx.doi.org/10.17816/jowd55475-476.
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M.M., 31 years old, the wife of an official, was admitted to the clinic of Professor G.E. Rein with complaints of general weakness, nervous disorders, headaches, dizziness, palpitations, constant pain in the abdomen and lower back, significantly increasing during regulation and each tension, pain during copulation, constipation and pain during bowel movement, frequent urge and pain during urination; comes from a consumptive family; In childhood, she suffered from scrofula, an English disease, anemia and pains; at the 15th year she suffered measles, at the 17th - pneumonia; the first month - in the 11th year, very profuse, with severe pains, lasted 7 days; the second - after 2 years, of the same nature; after 16 years, the correct menstruation was established, after 4 weeks for 7 days. She was married twice; in a month after entering the first marriage (husband suffered from overfusion) had an early (2 weeks) miscarriage, 6 weeks old; the second husband suffered from syphilis and transfusion and was relatively impotent; since this time, the patient's suffering has increased significantly; The used doctors determined that she had an abnormal position of the uterus. Upon admission to the clinic, retroflexio uteri fixata, oophoritis et salpingitis duplex (pelveoperitonitis) were found. Applied during the month of treatment (rest, warming compresses, scarification of the vaginal part, idoform in balls, etc.), as well as repeated attempts to correct the position of the uterus without result; in view of this, it was decided to perform a ventrofixatio uteri retroflexi fixati operation (hysteropexia abdominalis anterior. Ref.), moreover, that at the same time it was possible to produce salpingotomy.
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van Thiel, S. W., J. J. Bax, N. R. Biermasz, E. R. Holman, D. Poldermans, F. Roelfsema, H. J. Lamb, et al. "Persistent diastolic dysfunction despite successful long-term octreotide treatment in acromegaly." European Journal of Endocrinology 153, no. 2 (August 2005): 231–38. http://dx.doi.org/10.1530/eje.1.01955.
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Introduction: This study was designed to evaluate potential reversibility of left-ventricular (LV) dysfunction in patients with acromegaly following long-term control of disease. It is unknown whether the cardiac changes induced by acromegaly can be reversed completely by long-term strict control of growth hormone excess by octreotide. Patients and methods: We compared LV systolic and diastolic function in inactive patients with acromegaly (n = 22), who were divided into patients with long-term control by octreotide (n = 14) and patients with long-term cure by surgery/radiotherapy (n = 8). We also assessed these parameters in patients with active acromegaly (n = 17). Results: In patients with active acromegaly, systolic function at rest was decreased by 18% (P < 0.01), LV mass index increased by 40% (P < 0.04) and isovolumetric relaxation time increased by 19% (P < 0.01), compared with patients with inactive acromegaly. These parameters were not different between well-controlled and cured patients. Using tissue Doppler imaging, the ratio between early and late diastolic velocity (E′/A′ ratio) was decreased in active, compared with inactive acromegaly (0.75±0.07 versus 1.24±0.15; P < 0.01). This E′/A′ ratio was considerably higher in cured, compared with octreotide-treated, patients (1.75±0.41 versus 1.05±0.1; P < 0.01). Conclusion: Diastolic function is persistently and significantly more impaired in acromegalic patients with long-term control by octreotide than in surgically cured patients, which points to biological effects of subtle abnormalities in growth hormone secretion. Criteria for strict biochemical control of acromegaly should thus be reconsidered.
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Abrahams, Alferso C., Wim Rüger, Pieter M. ter Wee, Frans J. van Ittersum, and Walther H. Boer. "Improved Outcome of Enteric Peritonitis in Peritoneal Dialysis Patients Aged 50 Years and Older with Temporary Discontinuation of Peritoneal Dialysis and Intravenous Meropenem." Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis 37, no. 3 (May 2017): 298–306. http://dx.doi.org/10.3747/pdi.2016.00147.
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Background Peritonitis is a major cause of morbidity, mortality, and technique failure in peritoneal dialysis (PD) patients, especially when caused by enteric microorganisms (EM). We have implemented a treatment protocol specifically aimed at improving the outcome in EM peritonitis. The adapted protocol was applied in all PD patients 50 years and older presenting with peritonitis who were considered to be at risk of EM peritonitis and involves 3 interventions: 1) temporary discontinuation of PD without removing the catheter (peritoneal rest), 2) intravenous meropenem, and 3) meropenem intracatheter as lock (Mero-PerRest protocol). Methods In this observational study, we compared the outcome of 203 peritonitis episodes in 71 patients treated with the Mero-PerRest protocol, with 217 episodes in 104 patients treated with a more traditional intraperitoneal gentamicin-rifampicin-based regimen. Results In EM peritonitis episodes, the Mero-PerRest protocol resulted in a higher primary cure rate (90.0% vs 65.3%, adjusted odds ratio [OR] 4.54 [95% confidence interval (CI) 1.46 – 14.15]) and better technique survival (90.0% vs 69.4%, adjusted OR 3.41 [95% CI 1.07 – 10.87]). This effect was most distinct in patients with polymicrobial EM peritonitis (cure rate 87.5% vs 34.8%, p = 0.0003). Interestingly, primary cure rate (95.6% vs 84.7%, adjusted OR 3.92 [95% CI 1.37 – 11.19]) and technique survival (95.6% vs 85.6%, adjusted OR 3.60 [95% CI 1.25 – 10.32]) were also excellent in non-EM peritonitis episodes. Patient survival did not differ significantly. Conclusion The poor outcome of peritonitis caused by EM in PD patients aged 50 years and older could be improved by applying a treatment protocol involving temporary discontinuation of PD without catheter removal and intravenous and intracatheter meropenem.
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Khan, R., S. H. Harris, A. K. Verma, and A. Syed. "Cervical lymphadenopathy: scrofula revisited." Journal of Laryngology & Otology 123, no. 7 (October 10, 2008): 764–67. http://dx.doi.org/10.1017/s0022215108003745.
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AbstractBackground:The commonest form of extrapulmonary tuberculosis is tubercular cervical lymphadenitis, or scrofula.Methods and results:A total of 1827 patients with cervical lymphadenopathy who presented to various out-patients clinics of our institution were studied over a three-year period. Eight hundred and ninety-three (48.87 per cent) of these patients had lesions of tubercular origin. The most common observation was unilateral, matted adenopathy in female patients aged between 11 and 20 years and without constitutional symptoms of tuberculosis. Posterior triangle nodes were affected in 43.8 per cent of cases, followed by upper deep cervical nodes in 33.9 per cent. Fine needle aspiration cytology constituted the main diagnostic tool, with a positive yield in 90 per cent of patients. Polymerase chain reaction analysis was performed in 126 patients, with a sensitivity of 63 per cent. Only 18 per cent of patients had associated pulmonary tuberculosis, the rest having isolated involvement of cervical nodes. Medical treatment with anti-tubercular drugs for a period of six months formed the mainstay of treatment and cure. Surgical management was reserved for selected refractory patients.Conclusion:Tubercular cervical lymphadenitis can readily be diagnosed by fine needle aspiration cytology, a simple and cost-effective test. The disease can be cured completely by a short course of anti-tubercular chemotherapy, without surgical intervention.
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Syamsurizal, Syam. "Type-2 Diabetes Mellitus of Degenerative Disease." Bioscience 2, no. 1 (March 30, 2018): 34. http://dx.doi.org/10.24036/02018219980-0-00.
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Diabetes mellitus as a degenerative disease is difficult to cure but can be prevented by knowing the symptoms from the beginning. Developmental stage of diabetes: normal, prediabetes and diabetes. Diabetes mellitus can be divided into type-1 diabetes mellitus, type 2 diabetes mellitus, gestational diabetes mellitus and other types of diabetes mellitus. People with diabetes melitus type-2 90% of all diabetics. Type 2 diabetes mellitus is inherited polygenically. The genes that cause type 2 diabetes melitus include TCF7L2 gene, KCNJ11, HHEX, SLC30A8, CDKAL1, CDKN2A / 2B, IGF2BP2, and KCNQ, PPARG CAPN10, MC4R and FTO Genes. Type 2 diabetes mellitus risk factors: family history of diabetes mellitus, obesity, smokers, hypertension, history of coronary heart disease, lack of rest, and stress.Key words: DM, TCF7L2 and SNP
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Shinjo, Kiyoshi. "Revolutionary Treatment of Arthrosis - The Core Drainage Method-." Key Engineering Materials 309-311 (May 2006): 1375–78. http://dx.doi.org/10.4028/www.scientific.net/kem.309-311.1375.
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I have been able to recognize a new pathogenesis of arthrosis. According to this pathogenesis, I have developed a new treatment to drain the joint fluid from the lesional bone marrow. This new treatment is referred to as “Core Drainage.” The benefits of my “Core Drainage” method were effective for late stage arthrosis and resulted in almost immediate pain relief. This is a minimally invasive procedure that does not require bed rest post-operatively. Patients are able to bear weight immediately. Core Drainage can prevent progression of arthrosis and can even cure arthrosis at an early stage. With this technique, degenerated and worn joint cartilage was regenerated, and joint effusion and contracture were almost eliminated. The Core Drainage method greatly enhances the patient’s quality of life.
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Shettar, Manjunath, Pavan Hiremath, U. Achutha Kini, and Sathya Shankar Sharma. "Investigation on Effect of Nano-Fillers on Mechanical Properties of Epoxy Based Composites Using ANOVA." Materials Science Forum 904 (August 2017): 137–41. http://dx.doi.org/10.4028/www.scientific.net/msf.904.137.
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The present work aims to fabricate and characterize epoxy based composites with varying wt. % of nanoparticles as filler and to investigate and analyze the effects of nanoclay and nanocarbon with different wt. % on the epoxy resin. Different types of composites are prepared using 0, 2, 4 and 6 wt. % of fillers with rest of epoxy resin. Fillers are mixed with the resin by high speed mechanical stirrer for 2 hours. The mixture is transferred to the mould and allowed to cure. The specimens are prepared based on ASTM standard. The specimens are tested for tensile and flexural strength. Adding fillers resulted in change in the basic properties. ANOVA is applied to find the significance effect of 4 different weight percentage of fillers and different variety of fillers on the properties of composites.
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Liu, Ai-Feng, Shu-Wei Gong, Ji-Xin Chen, and Jing-Bo Zhai. "Efficacy and Safety of Acupuncture Therapy for Patients with Acute Ankle Sprain: A Systematic Review and Meta-Analysis of Randomized Controlled Trials." Evidence-Based Complementary and Alternative Medicine 2020 (October 16, 2020): 1–10. http://dx.doi.org/10.1155/2020/9109531.
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Background. The efficacy of acupuncture for acute ankle sprain (AAS) is controversial. This study aimed to critically assess the efficacy and safety of acupuncture for AAS. Methods. Parallel-group randomized controlled trials (RCTs) were included regardless of language or publication date. Participants with AAS were included regardless of age, sex, race, nationality, or diagnostic criteria for AAS. Experimental interventions included acupuncture alone or in combination with traditional therapies. Control interventions included no treatment, placebo, or traditional therapies. The primary outcome was the Kofoed ankle score. The secondary outcomes included visual analogue scale, duration of pain, use of painkiller, ankle circumference, effective rate, cure rate, and adverse events. PubMed, Embase, Cochrane Library, Web of Science, China National Knowledge Infrastructure, Wanfang Digital Periodicals, and Chinese Science and Technology Periodicals database were searched to identify potentially eligible studies from inception to September 10, 2020. World Health Organization International Clinical Trials Registry Platform (WHO ICTRP), ClinicalTrials.gov, Chinese Clinical Trial Registry (ChiCTR), and the reference list of eligible RCTs were checked to identify ongoing or unpublished studies. Risk of bias was assessed by the Cochrane Collaboration’s tool. Statistical analyses were performed by RevMan 5.3 software. P < 0.05 indicated statistical significance. Results. Seventeen eligible studies were included for the statistical analysis. There was no statistically significant difference of Kofoed ankle score between acupuncture and Rest, Ice, Compression, and Elevation (RICE) group ( P = 0.75 ). However, acupuncture could significantly relieve pain ( P = 0.02 ) and increase cure rate ( P = 0.004 ) compared with RICE. Moreover, acupuncture plus RICE could also significantly relieve pain ( P < 0.00001 ) and increase cure rate ( P = 0.01 ) compared with RICE alone. Acupuncture combined with massage could significantly relieve pain ( P = 0.04 ) compared with massage alone. Acupuncture plus Chinese medicine might be more effective for relieving pain ( P < 0.00001 ), reducing the duration of pain ( P < 0.00001 ), and increasing cure rate ( P = 0.0002 ) compared with Chinese medicine alone. Two studies reported no adverse reactions. One study reported that a participant suffered from mild drug-related allergic reaction and was healed without treatment. Conclusions. The findings of the present study suggest that acupuncture may be beneficial for AAS. However, more large-scale and well-designed RCTs are warranted.
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Sougaris, Savvas, CN Brozos, E. Petridou, Th Papadopoulos, and E. Kiossis. "Abrupt and gradual drying-off procedure and intramammary dry treatment: Impact on udder health status of Chios breed dairy sheep." Journal of the Hellenic Veterinary Medical Society 73, no. 2 (July 10, 2022): 4031–40. http://dx.doi.org/10.12681/jhvms.26304.
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In order to evaluate the impact of drying-off procedure on udder health status and the effect of intramammary dry treatment on prevention of new intramammary infections and improving cure rate of mammary abnormalities, a randomized single blinded controlled trial was performed in which 80 Chios breed dairy ewes were randomly allocated into 2 groups. Ewes of Group A (n=40) dried off gradually during a 15-day period, whereas in ewes of Group B (n=40), udder drying-off took place abruptly. Half of the ewes of each group received intramammary infusion (1 syringe/teat) of benzathine cloxacilline (IDT subgroup, n=20). The rest of the ewes of each group received no treatment at all (control subgroup, n=20). Representative samples of teat duct material and milk were aseptically collected from each mammary half for cytological and microbiological examination. Samples were collected using both conventional and aseptic techniques at the time of enrollment until the final milking before dry off (7 to 14 days before the expected dry period), at dry period (approximately 65 days) and continued at lambing until the end of the ongoing milking period. 61.8% of bacterial isolates obtained from teat duct and milk were identified as coagulase-negative staphylococci (CNS). No significant differences were noticed between the two groups in the frequency of mammary gland infection peri-partum (p=0.466), in the risk of new mammary infections during dry period (p=0.750) and in the cure rate of any subsequent mammary infection (p=0.131). Drying-off procedure had no significant impact on somatic cell counts (p=0.760) or milk leucocyte subpopulations (p>0.05) but had a significant effect on milk production of the next lactation period (p<0.001). Ewes treated with antibiotic agent presented a significantly higher cure rate of subsequent mammary infections (p=0.036) and a significantly lower risk of new mammary infections (p=0.039) during dry period, compared to the control group. No statistically significant differences were noticed concerning the impact of treatment on cytological profiles (p>0.5), somatic cell counts (p=0.581) and milk production (p=0.705). The results strengthen the hypothesis that drying off procedure does not affect cure rate neither reduce the risk of new infections during dry period and has no effect on development of mastitis around dry period whereas the use of intramammary dry treatment provides a better bacteriological cure rate of the mammary gland and decreases the possibility of new intramammary infections during dry period.
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Rydberg, Andreas. "Johann Georg Zimmermann’s Therapeutics of Solitude in the German Enlightenment." Emotions: History, Culture, Society 5, no. 2 (December 23, 2021): 259–78. http://dx.doi.org/10.1163/2208522x-02010130.
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Abstract This essay charts the German eighteenth-century physician and writer Johann Georg Zimmermann’s monumental work on solitude. The essay draws on but also challenges recent historiography on two counts. First, it situates Zimmermann’s discourse on solitude in the context of the early modern cultura animi tradition, in which philosophy provided a cure for a soul perceived as diseased and perturbed by passion and desire. Placed in this context, solitude comes into view not primarily as a passive state of rest and tranquillity connected to the rural life, but as active, therapeutic and exercise-oriented work on the self. Second, it argues that Zimmermann also shaped his discourse in relation to the increasingly radical late eighteenth-century exploration of subjectivity and selfhood, an exploration that reflects the emergence of the modern conception of the unique individual and autonomous self.
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Theodorakakou, Foteini, Despina Fotiou, Vasiliki Spiliopoulou, Magdalini Migkou, Maria Roussou, Panagiotis Malandrakis, Ioannis Ntanasis-Stathopoulos, et al. "Curability of Light Chain (AL) Amyloidosis with Conventional Dose Regimens." Blood 142, Supplement 1 (November 28, 2023): 6756. http://dx.doi.org/10.1182/blood-2023-189926.
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Novel immunotherapies in AL amyloidosis (AL) are associated with improved outcomes while the use of ASCT in selected patients can offer long term remissions. Since the plasma cell clones are usually small or modest, sustained hematologic remissions are not uncommon in AL amyloidosis; however, the “curability” of the disease remains to be demonstrated: even in patients (pts) who achieve deep and sustained hematologic responses, irreversible organ damage can lead to inferior survival. To identify clinical and disease characteristics that are associated with potential “functional cure” (“cure”) of the disease we analyzed a cohort of patients with AL treated without ASCT and with a follow up of at least 5 years. We defined“ ”cure“ as survival of at least 5 years without hematologic disease progression (PD) and without need for any salvage therapy. The analysis included consecutive pts with AL, treated in the Department of Clinical Therapeutics, Athens Greece, diagnosed until 6/2018; pts who survived < 6 months were excluded to adjust for early mortality associated with severe cardiac involvement. The final cohort included 210 pts and we focused on pts who: had not had hematologic PD, had not received any salvage therapy, were still alive or had died from causes not related to AL. These pts were defined as “functionally cured” while the rest as “non-cured”. Among the “cured” we identified a group of pts that despite hematologic response they progressed to end-stage renal disease. We considered that this was “predetermined” due to the advanced organ damage already at diagnosis. Lastly, we compared the outcome of “cured” pts with the outcome of “non-cured” pts who were on CR/VGPR and had ≥1-year or ≥5-year OS. The rate of “curability” was 17% (N=35). “Cured” pts had more often renal (84% vs 61%, p=0.045) and less frequent cardiac involvement (53% vs 62%, p=0.049), lower BM infiltration (8% vs 15%, p<0.001) and lower baseline dFLC (p=0.031) but higher levels of baseline proteinuria (p=0.031). The characteristics as well as the differences between “cured” and “non-cured” pts, are shown in Table 1. Most “cured” pts received bortezomib-based therapies (27 pts, 77%), oral melphalan was given in 4 pts (11%), while in 15 pts (42%) treatment also included lenalidomide and in 7 (20%) daratumumab (with or without bortezomib). Regarding hematologic response, 33 (94%) “cured” pts had achieved ≥ VGPR (CR: 22, VGPR: 11) vs 46% for “non-cured” (p<0.001), 18 pts (51%) had ≥ VGPR with low dFLC response criteria (dFLC <10mg/L) vs 20% (p<0.001); 6 pts (17%) had only low dFLC VGPR and 4 (11%) were not evaluable for response due to low dFLC levels. At 1- and 3-months from start of therapy, 24 (68%) and 27 pts (77%) “cured” pts had achieved ≥VGPR. MRD evaluation was available in 19 “cured” pts, and 11 (31%) were MRD negative (vs 3 (2%) for “non-cured” pts, p<0.001). Cardiac response was observed in 9 pts (25%) and renal response in 18 “cured” pts (51%). Among “cured” pts there was a group of 7 pts (20%) with end-stage renal disease; 1 (2.8%) was already on dialysis at the time of diagnosis, while 6 (17%) initiated dialysis during disease course, despite deep hematologic responses (3 CR, 3 VGPR); 3 pts were renal stage 2 and 3 were renal stage 3. Median time to dialysis was 27 months. Baseline clinical and disease characteristics were comparable among pts with and without end-stage renal disease. The median follow-up of the whole cohort was 88 months, and among “cured” pts, 3 (8.5%) died from causes unrelated to AL amyloidosis. The 7- year OS rate for “cured” pts was 100% and for “non-cured” was 41%, respectively. In 1- and 5-year landmark survival analysis, “cured” pts had significantly superior outcome compared to “non-cured” pts with CR/VGPR, with median OS not reached vs 66 months (p<0.001) and not reached vs 98 months (p=0.014), respectively (Fig 1). In conclusion, a subgroup of pts with AL, not treated with ASCT, can have long-term survival (≥ 5 years) without need for additional or salvage therapy. Such patients could be considered as functionally “cured”. High rates of rapid and deep hematologic responses, relatively high rates of MRD negativity and relatively low tumor and free light chain burden characterize this subset, further emphasizing the need for early diagnosis and active therapy to maximize clonal responses. Thus, “curability” in AL amyloidosis is feasible, especially in the era of novel therapies.
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Beals, Corey, and David Flanigan. "A Review of Treatments for Iliotibial Band Syndrome in the Athletic Population." Journal of Sports Medicine 2013 (2013): 1–6. http://dx.doi.org/10.1155/2013/367169.
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Iliotibial band syndrome (ITBS) is a common injury in runners and other long distance athletes with the best management options not clearly established. This review outlines both the conservative and surgical options for the treatment of iliotibial band syndrome in the athletic population. Ten studies met the inclusion criteria by focusing on the athletic population in their discussion of the treatment for iliotibial band syndrome, both conservative and surgical. Conservative management consisting of a combination of rest (2–6 weeks), stretching, pain management, and modification of running habits produced a 44% complete cure rate, with return to sport at 8 weeks and a 91.7% cure rate with return to sport at 6 months after injury. Surgical therapy, often only used for refractory cases, consisted of excision or release of the pathologic distal portion of the iliotibial band or bursectomy. Those studies focusing on the excision or release of the pathologic distal portion of the iliotibial band showed a 100% return to sport rate at both 7 weeks and 3 months after injury. Despite many options for both surgical and conservative treatment, there has yet to be consensus on one standard of care. Certain treatments, both conservative and surgical, in our review are shown to be more effective than others; however, further research is needed to delineate the true pathophysiology of iliotibial band syndrome in athletes, as well as the optimal treatment regimen.
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Johnson, Andrew. "Re-centreing the city: Spirits, local wisdom, and urban design at the Three Kings Monument of Chiang Mai." Journal of Southeast Asian Studies 42, no. 3 (September 9, 2011): 511–31. http://dx.doi.org/10.1017/s0022463411000385.
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Recent political events, such as the coup of 2006 or the ‘Red Shirt’ uprisings of 2010 underlined the divisions in Thai society between the provinces and the capital. As one of the world's most primate cities, Bangkok exerts a tremendous political, economic and cultural force upon the rest of Thailand. But how is such pressure interpreted, internalised and/or subverted? In this article, I look at Thailand's second-largest city, Chiang Mai, in Thailand's North, and the struggle to cure an increasing sense of urban crisis and thereby assert the former independent capital's symbolic authority vis-à-vis Bangkok. I examine this by looking at two specific discourses: that of architecture and spirit mediumship. Northern Thai architects attempt to cure Chiang Mai's ills through recourse to the ‘cultural heritage’ of the city's urban space, while spirit mediums call upon the sacred power of that space in order to restore Chiang Mai's ‘lost’ prosperity. The focal point for each effort lies at the city's centre: the Three Kings Monument and its surrounding plaza (khuang). Here, each group casts themselves as those most able to put Chiang Mai's past in physical form and thereby ensure Chiang Mai's future. In this article, I examine how ideas of cultural heritage become entwined with magico-religious concepts of power (sak). In each, there is a search for efficacious power in the face of political and cultural domination from Bangkok.
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Torensma, Ruurd. "The Dilemma of Cure and Damage in Oligodendroglioma: Ways to Tip the Balance Away from the Damage." Cancers 10, no. 11 (November 12, 2018): 431. http://dx.doi.org/10.3390/cancers10110431.
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Current treatments for oligodendrogliomas are powerful but have a negative impact on the rest of the body. The bone marrow is damaged by the chemotherapeutics, but other parts of the body are also affected. In this paper, the current treatment method and its collateral damage is described. Therefore, therapies are needed that are more effective against the tumor while having less negative effects on the patient’s quality of life. Some potential therapies include optimal removal of the tumor by fluorescent-guided surgery (FGS), intraoperative desorption electrospray ionization-mass spectrometry (DESI-MS), better monitoring of the effects of therapy by pseudo-coloring shades of gray of MRI pictures, and using recent data from RNA sequencing of single cells and immunotherapy. These are all open new ways of treating this tumor. The RNA sequencing of single tumor cells unravels specific tumor antigens present in the differentiation status of the cancer cell. Stem cell antigens were expressed in dividing cells, while hypoxia inducible factor-α (HIF-1α) is expressed in all tumor cells. Cancer stem cell antigens can be loaded on dendritic cells to induce cytotoxic T-cells directed to cancer stem cells. These recent discoveries suggest a better quality of life with the same overall survival.
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Neeli, Sashidhar Deveekrishna, Harikamal Kunapareddy, Sanjay C. Desai, Chandrashekar Anagavalli Ramswamy, Suhas Srinivas Gowda, and Sriram Manchikanti. "Functional Outcomes after Surgical Management of Peripheral AVM at a Tertiary Care Center." Indian Journal of Vascular and Endovascular Surgery 11, no. 1 (January 2024): 26–30. http://dx.doi.org/10.4103/ijves.ijves_69_23.
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Abstract Introduction: Arteriovenous (AV) malformations (AVMs) are rare vascular developmental orders containing an arterial network draining directly into one or more veins without a capillary bed, accounting for 1.5% of total vascular anomalies. Clinical presentations include pulsating mass, pain, ulceration, bleeding, tissue necrosis, enlargement of draining vein, and venous hypertension and/or cardiac failure. Treatment modalities include surgical excision, coil embolization, and sclerotherapy. Surgical excision offers an opportunity for cure but is associated with a risk of injury to vital structures, causing permanent impairment. Due to the high-risk nature of the lesion, it is important to study the clinical presentation and management of peripheral AVM for better management of these patients. Objectives: The objective was to study the presentation, management, and postoperative outcomes in terms of recurrence and functional status of the limb after surgical management of AVMs. Patients and Methods: It was a retrospective study done for 5 years (2018–2023). Thirteen patients who underwent surgical excision of peripheral AVM were included. Recurrence and functional status were assessed by clinical evaluation during follow-up outpatient department visits. Conclusion: The mean age of presentation is 33 years, with male preponderance (70%). Seven patients had upper limb AVMs (four had forearm involvement, while the rest had elbow region involvement). Six patients had lower limb AVMs, out of which four patients had involvement of the thigh region, one had in the knee, and the other in the calf. All patients complained of difficulty in performing daily activities due to the lesion. Nine patients underwent direct surgical excision, and four patients underwent AVM embolization before surgery (three patients had coil embolization, and one had onyx embolization). The mean duration of stay in the hospital was 5 days. Three patients were advised body contour stockings at follow-up. Two patients had recurrence (one after 6 months of surgical excision and the other had prior coil embolization), and one patient (had preembolization) had continued difficulty in walking postprocedure. The rest of the patients did not develop recurrence/functional impairment. There was no postoperative mortality. Thus, surgical excision offers a chance at cure with durable, functional outcomes in patients with peripheral AVMs.
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Paget-Blanc, Alexandra, Stephen Smagula, Rebecca Thurston, Yuefang Chang, and Pauline Maki. "0056 Rest-Activity Rhythms (RARs) and Cognitive Functions in Early Post-menopausal Women." Sleep 45, Supplement_1 (May 25, 2022): A26. http://dx.doi.org/10.1093/sleep/zsac079.054.
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Abstract Introduction RAR disruptions are more common among individuals with dementia than healthy individuals. In healthy older women, RAR disruption predicted future diagnosis of Mild Cognitive Impairment (MCI). With no cure for Alzheimer’s Disease, it is crucial to identify modifiable risk-factors for early prevention of cognitive decline. Here we aim to determine whether RAR disruption was associated with cognitive status and cognitive performance in early post-menopausal women, thereby representing a modifiable risk factor for dementia. Methods The sample drawn from MsBrain study, included 229 cognitively unimpaired women and 42 women with MCI/dementia, based on score on Montreal Cognitive Assessment (MOCA) adjusted for age and race. Participants completed a 72-hour wrist actigraphy monitoring and neuropsychological assessment including: California Verbal Learning Test (CVLT), Letter Number Sequencing (LNS), Card Rotation Test, Symbol Digit Modalities Test (SDMT). Latent profile analysis (LPA) was performed using five nonparametric RAR variables (intra-daily variability (IV), inter-daily stability (IS), relative amplitude (RA), alpha and F-statistic). The association between RAR clusters and cognitive performance and the relationship between RAR clusters, cognitive status and race/ethnicity were assessed using linear regression models, controlling for age, race/ethnicity, education and body mass index (BMI); and using chi-square test respectively. Results LPA revealed three clusters: Robust with high F-Stat, RA and IS and low IV; Normal;Weak with low RA and high alpha. The proportion of subjects with MCI/dementia did not differ between clusters however there was a significant association between race and RAR clusters, X2 (2, N = 271)=14.18, p<0[P1] .001, with non-white women more likely than white women to belong in the Weak group (p < .01). In an adjusted analysis of healthy women, the Weak group performed worse than the Robust group in LNS control (p<.050 ). In the unadjusted model, the Weak group performed worse than Robust group in CVLT Total Learning and Long Delay Recall and SDMT (p=.0074, p=.011and p= .0041, respectively). Conclusion Non-white women had weaker RAR than their white counterparts. Weaker RARs related to poorer working memory as measured by LNS; and poorer verbal memory and processing speed, measured by CVLT and SDMT however these effects were largely influenced by covariates, particularly race/ethnicity and education. Support (If Any)
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Azeredo-Coutinho, Rilza Beatriz G. de, and Sergio C. F. Mendonça. "An intermittent schedule is better than continuous regimen of antimonial therapy for cutaneous leishmaniasis in the municipality of Rio de Janeiro, Brazil." Revista da Sociedade Brasileira de Medicina Tropical 35, no. 5 (October 2002): 477–81. http://dx.doi.org/10.1590/s0037-86822002000500009.
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This study reviews a series of cutaneous leishmaniasis cases diagnosed and treated in outpatient units in the municipality of Rio de Janeiro, where the intermittent schedule of antimonial therapy was replaced by the continuous regimen. Both schedules were based on daily intramuscular injections of pentavalent antimonial. Forty-nine subjects received the intermittent regimen, consisting of three ten-day series alternated with ten-day rest intervals whereas seventy-one patients received the continuous regimen during 20 consecutive days. The study groups had similar composition regarding age, sex and clinical condition. The cure rate was significantly higher in the group receiving the intermittent schedule than in the group receiving continuous therapy (89.8% vs 63.3%). Moreover, loss to follow-up was significantly more frequent in the group receiving continuous therapy (19.7% vs 4.1% in the intermittent therapy). Under field conditions, the intermittent regimen provided higher effectiveness and adherence than the continuous schedule.
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Burkholder, David B., and Christopher J. Boes. "Silas Weir Mitchell on Epilepsy Therapy in the Late 19thto Early 20thCenturies." Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 41, no. 6 (November 2014): 769–72. http://dx.doi.org/10.1017/cjn.2014.42.
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AbstractSilas Weir Mitchell (1829-1914), one of the fathers of American neurology, is well known for many contributions to neurology. However, his efforts in epilepsy are overshadowed by his other accomplishments. Mitchell introduced a new bromide preparation, lithium bromide, as a viable therapy. His most widely accepted contribution to the field was the introduction of inhaled amyl nitrite for early termination of seizures accompanied by an appropriate aura. Despite the prevalent views on lifestyle modification as a treatment for epilepsy during this time period, as well as Mitchell's own development of the “rest cure” for certain disease states, he was not a proponent of these types of interventions for epilepsy, nor did he support interventions focused on other organ systems, such as abdominal or gynecologic surgery. Mitchell had distinct opinions on the treatment of epilepsy, and helped to advance its therapeutics during his career.
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Sutema, Ida Ayu Manik Partha, Made Sudiari, and I. Gede Palguna Reganata. "Analysis of Factors Affecting Healing of Acute Pharyngitis Viral Patients in Puskesmas I, Klungkung-Bali." WMJ (Warmadewa Medical Journal) 7, no. 2 (November 30, 2022): 60–69. http://dx.doi.org/10.22225/wmj.7.2.4753.60-69.
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Abstract
Antibiotic resistance is closely related to the inappropriate use of antibiotics, namely the indication, dose, frequency, and duration of use. Permenkes No. 5 of 2014 states that acute pharyngitis is given antibiotic therapy if it meets the diagnostic criteria using the center criteria, but this criterion is difficult to apply because doctors take longer to diagnose. Previous research at the Klungkung I Primary Health Center used diagnosis utilizing a swab test. It was found that 100% of bacterial pharyngitis patients were negative. The strategy of delaying antibiotics for 3 days can prevent antibiotic resistance, but in therapy, without antibiotics, it is important to increase the effectiveness of therapy, it is deemed necessary by the researchers to conduct a study to analyze the factors that affect the recovery of patients with acute pharyngitis, which are mainly caused by viruses. Analyzing the factors that affect the recovery of viral pharyngitis patients. The design of the cross-sectional study was through observation of the medical record data of patients who came to the Klungkung Primary Health Center I for 3 months and got diagnostic facilities using the swab test. Patients who got a negative swab test were analyzed for the factors that influenced their recovery. Anti-inflammatory variables, rest, and paracetamol significantly affected the recovery of acute pharyngitis patients (p <0.05), and the importance index in CART analysis found that paracetamol was the most influential, followed by rest, administration of vitamins, and anti-inflammatory. Antibiotics, anti-allergies, and cough medicines do not affect the recovery of patients with acute pharyngitis viral. Paracetamol has the most effect on patient recovery, followed by rest and administration of vitamins, anti-inflammatory has very little effect on the recovery in patients of acute pharyngitis viral.
Keywords: acute pharyngitis, cure, CART.