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Dissertations / Theses on the topic 'Resveratrol'

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Published: 4 June 2021

Last updated: 25 July 2025

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1

Carvalho, Paula Andréa Sampaio de Vasconcelos [UNESP]. "Concentração de resveratrol e expressão de resveratrol sintase em espécies de Arichis." Universidade Estadual Paulista (UNESP), 2013. http://hdl.handle.net/11449/108549.

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Made available in DSpace on 2014-08-13T14:50:44Z (GMT). No. of bitstreams: 0 Previous issue date: 2013-04-26Bitstream added on 2014-08-13T18:00:49Z : No. of bitstreams: 1 000753267.pdf: 1148159 bytes, checksum: e46fd3be4a1e5a94f82f31452ef03554 (MD5)<br>O resveratrol é uma fitoalexina produzida em função de estresses bióticos e abióticos e foi encontrado em um número limitado de espécies de plantas, incluindo o amendoim (Arachis hypogaea) e seus parentes silvestres. Este tem também propriedades antioxidantes e em função disso é um promissor antitumoral, cardioprotetor e neuroprotetor. O amend

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Carvalho, Paula Andréa Sampaio de Vasconcelos. "Concentração de resveratrol e expressão de resveratrol sintase em espécies de Arichis /." Botucatu, 2013. http://hdl.handle.net/11449/108549.

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Orientador: Marcos Aparecido Gimenes<br>Coorientador: Tânia da Silveira Agostini Costa<br>Coorientador: Ana Cristina Miranda Brasileiro<br>Banca: Marcia Ortiz Mayo Marques<br>Banca: Edvaldo Aparecido Amaral da Silva<br>Resumo: O resveratrol é uma fitoalexina produzida em função de estresses bióticos e abióticos e foi encontrado em um número limitado de espécies de plantas, incluindo o amendoim (Arachis hypogaea) e seus parentes silvestres. Este tem também propriedades antioxidantes e em função disso é um promissor antitumoral, cardioprotetor e neuroprotetor. O amendoim é um alotetraploide de c

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Nemen, Daiane. "Sistemas nanoestruturados lipídicos contendo resveratrol." reponame:Repositório Institucional da UFSC, 2012. http://repositorio.ufsc.br/xmlui/handle/123456789/93866.

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Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Farmácia, Florianópolis, 2010<br>Made available in DSpace on 2012-10-25T04:09:45Z (GMT). No. of bitstreams: 1 282460.pdf: 1697222 bytes, checksum: de64ff7e1688f94a0ed724700226a459 (MD5)<br>O resveratrol (RV) é um polifenol pertencente à classe dos estilbenos, presente na dieta humana. Esta substância tem demonstrado inúmeras atividades farmacológicas incluindo antitumoral, anti-inflamatória, antioxidante, cardioprotetora, entre outras. Entretanto, a biodisponibilidade oral

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4

Ressler, Daniel. "Synthesis of Resveratrol Ester Derivatives." Digital Commons @ East Tennessee State University, 2013. https://dc.etsu.edu/etd/1234.

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The goal of this research project was to synthesize derivatives of transresveratrol. In order for resveratrol to be activated and used by the body it needs to bind to Human Serum Albumin (HSA), a protein in blood plasma. The derivatives were synthesized to improve the ability of resveratrol to enter cells as well as improve their ability to bind to HSA. The three derivatives that were synthesized have converted one of the hydroxyl groups on resveratrol to an ether with a methylene chain terminated by a carboxylic acid. By varying the lengths of the methylene chain we varied the water solubilit

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Wang, Shan [Verfasser]. "The effect of resveratrol and resveratrol imine analogues on human tumor cell lines / Shan Wang." Hannover : Bibliothek der Tierärztlichen Hochschule Hannover, 2016. http://d-nb.info/1107794242/34.

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6

Bradaschia, Alice. "Resveratrol, a natural molecule against hypertension and cardiovascular diseases: development of prodrugs to enhance its bioavailability." Doctoral thesis, Università degli studi di Padova, 2012. http://hdl.handle.net/11577/3422913.

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Plant polyphenols are a vast family of natural compounds present in many foods and drinks. Many of them have noteworthy biological properties. Resveratrol, for example, can help prevent cardiovascular disease in humans, because it is able to lower blood pressure and lipid peroxidation, to induce vasodilatation and to reduce platelet aggregation. Moreover, resveratrol has antioxidant, anti-inflammatory, and anti-atherosclerotic properties, resulting in protection of the cardiovascular system, improvement of age-related cognitive decline and prevention and therapy of cancer. These potential posi

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7

Paulo, Luísa Alexandra Serrano. "Determinação dos teores de resveratrol em vinhos tintos com denominação de origem controlada Beira Interior e avaliação das suas propriedades antimicrobianas." Doctoral thesis, Universidade da Beira Interior, 2011. http://hdl.handle.net/10400.6/1004.

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Reconhece-se actualmente que o vinho tem propriedades benéficas no organismo humano, sendo constituído por compostos que exercem uma influência positiva no metabolismo dos indivíduos que o consomem com regularidade e moderação. O resveratrol (trans-3,4’,5-trihidroxiestilbeno) é uma fitoalexina que está presente em diversos alimentos e bebidas, em particular no vinho tinto. Das várias classes de polifenóis existentes no vinho, o resveratrol (estilbeno) é um dos compostos mais estudados do ponto de vista de importância biológica, devido aos potenciais efeitos benéficos para a saúde humana. Na p

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Moreno, Carolina dos Santos. "Estudo do efeito radioprotetor do resveratrol." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/85/85131/tde-06112009-100431/.

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Resveratrol (3,4,5-trihidroxiestilbeno), um polifenol pertencente ao grupo de compostos denominados fitoalexinas, é sintetizado por uma ampla variedade de plantas, tais como as videiras, em resposta a infecções fúngicas e a exposição à radiação UV. Nos vinhos este composto está presente em elevadas concentrações, sendo considerado um dos constituintes com maior potencial antioxidante. Esta elevada capacidade de absorver os radicais livres presentes em diversos processos biológicos permite ao resveratrol previnir doenças cardiovasculares e diversos tipos de câncer. O principal objetivo do prese

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Lieben, Louis Xavier. "Resveratrol mediated cardioprotection in obese rats." Journal of Nutritional Biochemistry, 2011. http://hdl.handle.net/1993/29506.

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Obesity is a major epidemic and an independent risk factor for heart disease. Food derived compounds such as resveratrol has been reported to have strong medicinal properties and shown potential in preventing and reversing heart diseases. This study investigated the cardioprotective properties of resveratrol in an animal model of diet induced obesity and possible cellular mechanisms. Obese prone (OP) and obese resistant (OR) rats were fed with high fat diet while, sprague dawley (SD) rats that served as control were fed with normal lab chow for a total of 17 weeks. During the last 5 weeks o

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MORENO, CAROLINA dos S. "Estudo do efeito radioprotetor do resveratrol." reponame:Repositório Institucional do IPEN, 2009. http://repositorio.ipen.br:8080/xmlui/handle/123456789/9440.

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Van, Cleve Shelley Marie. "Synthesis of a Resveratrol Glycinate Derivative." Digital Commons @ East Tennessee State University, 2011. https://dc.etsu.edu/etd/1312.

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Recently, the compound resveratrol has had media attention as an anti carcinogen. However, the bioavailability of resveratrol is low in the human system due to its hydrophobic nature. Therefore, it must be administered in high dosages to be effective. A plethora of derivatives have been synthesized that have the potential of resveratrol but sadly share low bioavailability. The first effort of this research was an attempt to produce a more hydrophilic ester of resveratrol. Failing this, the final product was synthesized using a glycine derivative to produce 4-[(1E)-2-(3,5-diacetyloxyphenyl)ethe

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Momesso, Roberta Grazzielli Ramos Alves Passarelli. "Incorporação e liberação de resveratrol em hidrogéis poliméricos." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/85/85134/tde-29082011-143430/.

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Resveratrol (3, 4, 5-trihidroxiestilbeno) é um polifenol produzido por uma grande variedade de plantas em resposta ao estresse e encontrado predominantemente em cascas de uvas. Este princípio ativo apresenta vários benefícios à saúde, como a capacidade antioxidante, relacionada à prevenção de diversos tipos de câncer e do envelhecimento precoce da pele. No entanto, apresenta baixa biodisponibilidade quando administrado por via oral, o que torna interessante sua aplicação tópica. O principal objetivo deste trabalho foi a incorporação de resveratrol em hidrogéis poliméricos para obtenção de um s

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Amaral, Catia Lira do. "Efeito do resveratrol na nefrotoxicidade induzida pela cisplatina em ratos." Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/60/60134/tde-22052007-090133/.

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O resveratrol (Res), um polifenol presente no vinho tinto, é conhecido por possuir potente atividade antioxidante. O efeito do resveratrol (Res) frente à nefrotoxicidade do antineoplásico cisplatina (cDDP) foi avaliado em ratos neste estudo. Os animais foram tratados com Res (25 mg/Kg de peso copóreo, ip., dose única) 30 minutos antes da administração de cisplatina (5 mg/Kg de peso copóreo, ip., dose única) e foram sacrificados depois de 2 ou 5 dias do tratamento. Após 5 dias, o aumento da creatinina sérica, volume urinário e proteinúria, que são marcadores de alterações renais, apresentaram s

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Morin, Katy. "The Role of SirT1 in Resveratrol Toxicity." Thèse, Université d'Ottawa / University of Ottawa, 2011. http://hdl.handle.net/10393/20492.

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SirT1 is a class III histone deacetylase that has beneficial roles in various diseases related to aging such as cancer, diabetes and neurodegenerative disease. Resveratrol is a natural compound that mimics most of the beneficial effects attributed to SirT1. Resveratrol has toxicity towards cancer cells and has been reported to be a direct activator of SirT1. Interestingly, SirT1 over-expression has also been reported to be toxic. We set out to determine if resveratrol toxicity is mediated through activation of SirT1. We have assessed resveratrol toxicity in embryonic stem cells and mouse embry

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Patel, Ketan R. "Potential cancer chemopreventive properties of resveratrol metabolites." Thesis, University of Leicester, 2011. http://hdl.handle.net/2381/9911.

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Resveratrol (trans-3,5,4′-trihydroxystilbene), a naturally occurring polyphenol present in grapes and red wine has undergone investigation as a potential cancer chemopreventive agent. Resveratrol is rapidly and extensively metabolised to its major phase II metabolites, including resveratrol sulfates and glucuronides. It is not yet known whether resveratrol metabolites contribute to the beneficial effects attributed to resveratrol, or whether resveratrol regeneration can occur from the metabolites. Resveratrol and metabolite pharmacokinetics were investigated in the plasma of healthy human volu

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Li, Haitao, and 李海濤. "Resveratrol derivatives as colorectal cancer chemopreventive agents." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B43703720.

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Armstrong, Gareth Owen. "The production of resveratrol by wine yeast." Thesis, Stellenbosch : Stellenbosch University, 2001. http://hdl.handle.net/10019.1/52557.

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Thesis (MSc)--Stellenbosch University, 2001.<br>ENGLISH ABSTRACT: Grapevine is constantly under attack from a wide variety of pathogens including viruses, bacteria and fungi. In order to ensure survival, the grapevine has developed a vast array of defense mechanisms to combat invading organisms. A key element of this disease resistance is the production of phytoalexins, of which resveratrol is the primary component. The synthesis of resveratrol, together with other structural and biochemical defense mechanisms equips the plant to combat a number of pathogens resulting in the production

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Poolman, Toryn. "Investigations into the cardioprotective properties of resveratrol." Thesis, University of Leicester, 2004. http://hdl.handle.net/2381/29695.

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In this study the ability of resveratrol to inhibit the activation of the monocyte respiratory burst was investigated.;Differentiated U937 (dU937) cells were pre-treated with resveratrol before stimulation with f-met-leu-phe (fMLP), phorbol 12-myristate-13-acetate (PMA) or arachidonic acid (AA). The extra-cellular and total production of reactive oxygen species (ROS) were measured by isoluminol and luminol chemiluminescence (CL). Superoxide production was measured using lucigenin. Resveratrol was found to inhibit ROS production induced by all three stimuli. Measurement of ROS production was al

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Quincozes-Santos, André. "Efeito do resveratrol sobre parâmetros bioquímicos astrogliais." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2010. http://hdl.handle.net/10183/117104.

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A espécie redox ativa resveratrol (3,5,4’-trihidroxi-trans-estilbeno), uma fitoalexina encontrada nas uvas e no vinho tinto, apresenta importantes efeitos biológicos como atividade antioxidante, anti-inflamatória, antitumoral e cardioprotetora. O sistema nervoso central (SNC) também é alvo do resveratrol que por sua vez pode atravessar a barreira hematoencefálica e exercer efeito neuroprotetor, modulando importantes funções neurogliais. Fisiologicamente os astrócitos controlam importantes funções cerebrais, principalmente, relacionadas ao metabolismo glutamatérgico, à plasticidade sináptica e

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Li, Haitao. "Resveratrol derivatives as colorectal cancer chemopreventive agents." Click to view the E-thesis via HKUTO, 2010. http://sunzi.lib.hku.hk/hkuto/record/B43703720.

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Jing, Stanley Mofor. "Synthesis of Resveratrol Esters and Aliphatic Acids." Digital Commons @ East Tennessee State University, 2011. https://dc.etsu.edu/etd/1382.

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Resveratrol (RV) is a naturally occurring phytoalexin of the stilbenoid family produced by some plant species, and present in grape skin, peanuts, and red wine. It has been found to exhibit anti-cancer, anti-inflammatory, anti-viral, anti-aging, cardio protective, and anti-oxidant properties. Bioavailability is a huge setback that limits the potentials of RV. As a result, efforts have been made to design and synthesize RV esters and aliphatic acids in an attempt to increase its bioavailability, solubility in water, and possibly improving its biological activities. Resveratrol esters, 3,5,4'-tr

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Carvalho, Paula Andréa Sampaio de Vasconcelos [UNESP]. "Teor de resveratrol no gênero Arachis L. e alotetraploides sintéticos e comportamento da resveratrol sintase em espécies de Arachis." Universidade Estadual Paulista (UNESP), 2017. http://hdl.handle.net/11449/151936.

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Submitted by PAULA ANDRÉA SAMPAIO DE VASCONCELOS CARVALHO null (paulasvasconcelos@hotmail.com) on 2017-10-06T14:46:03Z No. of bitstreams: 1 tese pos defesa Paula Andréa Sampaio de Vasconcelos Carvalho.pdf1.pdf: 1988306 bytes, checksum: 46c0925bf8ca00155c63f2c83d48acac (MD5)<br>Rejected by Monique Sasaki (sayumi_sasaki@hotmail.com), reason: Solicitamos que realize uma nova submissão seguindo a orientação abaixo: O arquivo submetido está sem a ficha catalográfica. A versão submetida por você é considerada a versão final da dissertação/tese, portanto não poderá ocorrer qualquer alteração

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Carvalho, Paula Andréa Sampaio de Vasconcelos. "Teor de resveratrol no gênero Arachis L. e alotetraploides sintéticos e comportamento da resveratrol sintase em espécies de Arachis." Botucatu, 2017. http://hdl.handle.net/11449/151936.

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Orientador: Marcos Aparecido Gimenes<br>Resumo: O gênero Arachis possui 81, espécies distribuídas em nove seções taxonômicas, sendo o amendoim (A. hypogaea L.) a principal espécie, devido ao seu alto valor nutricional. O gênero possui também outras espécies de interesse econômico, que têm sido utilizadas em programas de melhoramento do amendoim (espécies da seção Arachis) e espécies forrageiras de outras seções do gênero. Com relação às demais espécies, o germoplasma da grande maioria está disponível para a caracterização e pode, sem dúvida, contribuir para seu uso futuro. O gênero Arachis é u

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Thandapilly, Sijo Joseph. "Effects of resveratrol on hypertension induced cardiac remodelling." Nature Publishing, 2010. http://hdl.handle.net/1993/15342.

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Background: Cardiac hypertrophy is a compensatory enlargement of the heart in response to stress such as hypertension. It is beneficial in reducing stress placed on the heart. However, when the stress is of a chronic nature, it becomes pathological and leads to cardiac dysfunction and heart failure. Current treatments for hypertension and heart failure have proven beneficial but are not highly specific and associated with side effects. Accordingly, there is an important need for alternative strategies to provide safe and effective treatment. Methods: Ten-week-old male spontaneously hypertens

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Chiela, Eduardo Cremonese Filippi. "A autofagia e o ciclo celular desempenham papel central no mecanismo de ação do resveratrol e do co-tratamento com temozolomida em células de linhagens de glioblastoma humano." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2011. http://hdl.handle.net/10183/28430.

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Glioblastomas (GBMs) são os tumores primários (gliomas) mais comuns e agressivos do Sistema Nervosos Central, classificados pelos oncologistas como um dos maiores desafios da oncoterapia. O prognóstico dos pacientes é ruim mesmo após terapia cirúrgica seguida de radio e quimioterapia com Temozolomida (TMZ). Células de GBM apresentam resistência intrínseca à apoptose, porém, se mostram mais sensíveis à indução de senescência, autofagia e catástrofe mitótica. Resveratrol (Rsv) é um polifenol com ação neuroprotetora ao tecido neural sadio e, por outro lado, ação citotóxica em células de GBM. Poré

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Wang, TiengChung. "The effect of resveratrol on prostate cancer prevention." College Park, Md. : University of Maryland, 2006. http://hdl.handle.net/1903/3590.

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Thesis (M.S.) -- University of Maryland, College Park, 2006.<br>Thesis research directed by: Dept. of Nutrition and Food Science. Title from t.p. of PDF. Includes bibliographical references. Published by UMI Dissertation Services, Ann Arbor, Mich. Also available in paper.

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Simon, Charles. "Novel resveratrol analogues : synthesis, metabolism and cell proliferation." Thesis, University of Leicester, 2011. http://hdl.handle.net/2381/9289.

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Resveratrol or trans-3,4’,5-trihydroxystilbene is a naturally occurring phytochemical contained in red grapes skin, nuts and berries. It has been shown over the years to have different biological properties particularly in the chemoprevention of cancer. However, it is metabolised in vivo to sulfates and glucuronides within 1h and is active against different targets in a dose dependant manner. A library of new analogues of resveratrol has been synthesised with the aim of stopping or at least slowing down the metabolism whilst keeping its activity on the inhibition of cancer cell proliferation.

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Mendes, Jessica Bitencourt Emilio. "DESENVOLVIMENTO E AVALIAÇÃO DE MICROPARTÍCULAS POLIMÉRICAS CONTENDO RESVERATROL." UNIVERSIDADE ESTADUAL DE PONTA GROSSA, 2011. http://tede2.uepg.br/jspui/handle/prefix/102.

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Made available in DSpace on 2017-07-21T14:13:08Z (GMT). No. of bitstreams: 1 Jessica Bitencourt Emilio Mendes.pdf: 1572029 bytes, checksum: 2b2c9dc7481232e1bca34cb744c1ab6d (MD5) Previous issue date: 2011-09-17<br>Resveratrol is a potent antioxidant, anti-inflammatory, anticancer, and chemoprotective agent. However, it is sensitive to some external agents such as air, light and oxidative enzymes that can reduce its viability and bioavailability for clinical use. In order to provide a controlled release, the aim of this study was to obtain resveratrol-loaded polyester microparticles and to ev

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Assunção, Carolina Marinho de. "Efeito do resveratrol na criopreservação do sêmen bovino." Universidade Federal de Juiz de Fora, 2016. https://repositorio.ufjf.br/jspui/handle/ufjf/2250.

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MOMESSO, ROBERTA G. R. A. P. "Incorporacao e liberacao de resveratrol em hidrogeis polimericos." reponame:Repositório Institucional do IPEN, 2010. http://repositorio.ipen.br:8080/xmlui/handle/123456789/9524.

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Souza, Izabel Cristina Custodio de. "Efeitos do resveratrol sobre as células estreladas hepáticas." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2009. http://hdl.handle.net/10183/16161.

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As células estreladas hepáticas (HSC) são pericitos específicos do fígado, são células armazenadoras de gordura e produzem componentes de matriz extracelular. As HSCs ao serem ativadas, proliferam, perdem as gotas lipídicas e aumentam a secreção de matriz extracelular. O controle da modulação fenotípica e da proliferação das HSCs é de suma importância para entendermos a fibrose hepática. Esta pesquisa foi realizada com a linhagem celular GRX (representativa das HSCs murinas) obtida a partir de reações fibrogranulomatosas inflamatórias. Estudos anteriores, em nosso laboratório, pesquisaram a aç

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Kukulus, Vera. "Wirkung von Resveratrol auf die Biologie humaner Fettzellen." [S.l. : s.n.], 2008. http://nbn-resolving.de/urn:nbn:de:bsz:289-vts-64490.

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Teixeira, Claudener Souza. "DeterminaÃÃo da estrutura tridimensional de uma lectina de sementes de Canavalia maritima (Aublet) complexada com o polifenol antioxidante resveratrol." Universidade Federal do CearÃ, 2015. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=15090.

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CoordenaÃÃo de AperfeiÃoamento de Pessoal de NÃvel Superior<br>O resveratrol Ã um polifenol antioxidante natural encontrado especialmente na epicarpo da uva, em nozes e na romÃ o qual pode inibir a ativaÃÃo de mediadores prÃ-inflamatÃrio e citocinas na fase precoce de expressÃo do gene. JÃ Ã bem conhecido que as lectinas sÃo proteÃnas de ligaÃÃo de aÃÃcares que atuam tanto como molÃculas prÃ- e anti-inflamatÃrias. Assim, o objetivo do presente trabalho foi o de verificar a ligaÃÃo de um composto de polifenol com uma lectina de Canavalia maritima (ConM) com base na sua capacidade para inibir pr

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Di, Pascoli Marco. "Resveratrol administration improves intrahepatic endothelial dysfunction and reduces liver fibrosis and portal pressure in CCl4-cirrhotic rats." Doctoral thesis, Università degli studi di Padova, 2012. http://hdl.handle.net/11577/3422138.

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Background and Aims: In the Western countries, liver cirrhosis is the main cause of portal hypertension, which is defined as a clinical syndrome characterized by an increased hydrostatic pressure within the portal venous system. The importance of this syndrome is defined by the frequency and severity of its complications: gastrointestinal bleeding from ruptured gastroesophageal varices, ascites, hepatorenal syndrome and hepatic encephalopathy. In cirrhosis, the initial factor determining the onset of portal hypertension is the increase in intrahepatic vascular resistance, which is due to the m

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Romeiro, Thaís Helena. "Hidrocefalia experimental: o Resveratrol apresenta algum benefício como neuroprotetor?" Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/17/17137/tde-28072016-092829/.

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A hidrocefalia é uma condição neurológica complexa, em que ocorre o desequilíbrio na dinâmica do líquido cefalorraquidiano (LCR) provocando um distúrbio na produção, circulação e reabsorção do mesmo, o que pode levar a uma redução e/ou bloqueio do fluxo sanguíneo. Apesar do tratamento com derivação liquórica ser eficiente na redução da ventriculomegalia, muitos danos neurológicos não são revertidos com a cirurgia. Estudos demonstram que o estresse oxidativo está envolvido na gênese das lesões da hidrocefalia. O objetivo deste trabalho foi avaliar a resposta neuroprotetora do Resveratrol, recon

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Lin, Boren. "A novel resveratrol analog its cell cycle inhibitory, pro-apoptotic and anti-inflammatory activities on human tumor cells /." [Kent, Ohio] : Kent State University, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=kent1144769442.

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Sharan, Satish. "PHARMACOKINETICS OF RESVERATROL, ITS MONOCONJUGATES AND ITS TRIMETHOXY ANALOG TMS." Diss., Temple University Libraries, 2013. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/228695.

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Pharmaceutical Sciences<br>Ph.D.<br>Resveratrol (RES) has been associated with numerous pharmacological effects. Yet its pharmacokinetics is not clearly understood. It is known to get extensively metabolized into its sulfated and glucuronidated metabolites and has very low circulating RES concentrations in plasma. Although the concentrations of conjugated metabolites of RES have been reported to be much greater than that of RES, they have not been evaluated. This also becomes important in light of positive biological activities reported for sulfated metabolites of RES. Conjugation is a complex

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Cavalcante, Adriana Kuchinski. "Avaliação da ecotoxicidade do resveratrol no estágio embriolarval de peixes da espécie Danio rerio." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/85/85134/tde-03082017-074403/.

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A busca pelo homem por uma vida saudável tem impulsionado pesquisas por novas substâncias capazes de atender tal desejo. O composto fenólico resveratrol (3, 4\', 5- trihidroxiestilbeno) é uma dessas substâncias que apresenta uma variedade de ações farmacológicas, como potencial antioxidante, capacidade antiinflamatória, proteção contra doenças cardíacas e câncer. Apesar dos inúmeros estudos sobre os benefícios do resveratrol à saúde, há poucos dados na literatura sobre sua toxicidade em organismos aquáticos, e principalmente sua concentração no ambiente, tornando o presente estudo fundamental

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Cesar, Everton Felix. "Avaliação da potencial ação anti-neoplásica de resveratrol isolado e associado a etanol na carcinogênese induzida por N-metil-N'-nitro-N-nitrosoguanidina (MNNG) no cólon de ratos." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/17/17143/tde-10042018-145036/.

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Resveratrol (RESV), um polifenol presente em diversos compostos naturais, incluindo o vinho, tem sido associado a um efeito quimiopreventivo em diversos tipos de câncer, inclusive no câncer colorretal (CCR). Esse efeito benéfico observado em diversos estudos vem sendo atribuído, sobretudo, à sua ação anti-oxidante; muito embora o RESV também esteja envolvido em diversos outros mecanismos celulares, incluindo a apoptose. Não obstante, uma análise mais acurada sobre a potencial ação antineoplásica do RESV na promoção do CCR ainda se faz necessária. O CCR é um dos tipos de câncer mais frequentes

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Zamora, Ros Raul. "Resveratrol: Marcador dietètic i biològic del consum de vi." Doctoral thesis, Universitat de Barcelona, 2008. http://hdl.handle.net/10803/2440.

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El resveratrol és un component del vi, el qual té uns potencials efectes beneficiosos en malalties relacionades amb l'envelliment com poden ser el càncer, la malaltia cardiovascular, la diabetis i les malalties neurodegeneratives, augmentant l'esperança de vida d'organismes simples i mamífers actuant com a mimetic de la restricció calòrica. Els biomarcadors nutricionals poden ser una millor mesura de l'exposició dietètica que les dades estimades mitjançant enquestes alimentàries, perquè tenen tres grans avantatges envers les enquestes : a) els biomarcadors nutricionals són més precisos; b) les

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Haider, Ursula G. B. "Resveratrol Attenuates Vascular Smooth Muscle Cell Hypertrophy and Hyperplasia." Diss., lmu, 2003. http://nbn-resolving.de/urn:nbn:de:bvb:19-8688.

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Alatawi, Fatema Suliman. "An investigation of ageing-related genomic effects of resveratrol." Thesis, University of Newcastle upon Tyne, 2013. http://hdl.handle.net/10443/1943.

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Dietary restriction (DR) increases lifespan robustly in diverse species. Effects of the dietary polyphenol resveratrol consistent with delayed ageing and/or extension of lifespan have been reported. The involvement in the longevity response to DR of the protein Sirt1, which may be activated by resveratrol and deacetylates a range of cellular substrates that includes histone proteins, identifies epigenetic processes as a pathway that may mediate effects of both DR and dietary resveratrol in delaying ageing and/or extending lifespan. Based on a preliminary observation, the hypothesis underlying

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Polycarpou, Elena. "Efficacy of resveratrol metabolites on colon cancer cell growth." Thesis, Kingston University, 2013. http://eprints.kingston.ac.uk/26598/.

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Resveratrol is a natural polyphenol present in many plant species and derived foods including grapes and red wine. It has been shown to possess chemotherapeutic properties in animal cancer models as well as many biological effects in vitro. In this study, the effects of three resveratrol metabolites including resveratrol-3-0-D-glucuronide, resveratrol-4'-O-D-glucuronide and resveratrol-3-0-D-sulphate on the growth of colon cancer cell lines have been investigated. The growth inhibitory effects of resveratrol, piceatannol, pterostilbene and the glucuronide and sulphate metabolites on Caco-2, CC

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McCormick, R. "Cytokine-induced skeletal muscle atrophy : protective effect of resveratrol." Thesis, University of Liverpool, 2016. http://livrepository.liverpool.ac.uk/3003280/.

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Sarcopenia, the loss of muscle mass and function as we age, affects all individuals from approximately the 4th decade of life and results in a poor quality of life. The mechanisms responsible for sarcopenia are unclear and it is likely that it is a multifactorial disease. However, it is hypothesised that an increase in systemic and/or muscle pro-inflammatory cytokine levels play a major role. Interferon induced protein 10 (IP10) is a chemokine that has been shown to be increased in serum as we age. Polyphenols are extracts from plants and have been shown to have anti-inflammatory effects with

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Deus, Cláudia Maria Carrudo de. "Resveratrol e cancro - qual o papel para as sirtuinas?" Master's thesis, Universidade de Aveiro, 2012. http://hdl.handle.net/10773/10700.

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Mestrado em Biologia Aplicada<br>O cancro é uma doença com elevada incidência em todo o mundo. O processo de carcinogénese é bastante complexo e envolve uma série de transformações que culminam no desenvolvimento tumoral. É por isso necessário encontrar novas terapias que sejam menos agressivas ou que aumentem a eficiência da quimioterapia no combate ao cancro. Os polifenóis, nomeadamente o resveratrol têm sido apontados como compostos com efeitos quimioprotetores e citotóxicos em vários tipos de cancro, prevenindo e atrasando o desenvolvimento tumoral nos vários estágios do processo carcinogé

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Ortinau, Laura Grün Ingolf. "Resveratrol and procyanidin content in select Missouri red wines." Diss., Columbia, Mo. : University of Missouri--Columbia, 2009. http://hdl.handle.net/10355/5366.

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The entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract appears in the public.pdf file. Title from PDF of title page (University of Missouri--Columbia, viewed on December 29, 2009). Thesis advisor: Dr. Ingolf Gruen. Includes bibliographical references.

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Kane, Alice Elizabeth. "Paracetamol Toxicity: Influence Of Ageing, Frailty, Resveratrol And Sirt1." Thesis, The University of Sydney, 2015. http://hdl.handle.net/2123/14966.

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The objective of this thesis was to help improve the safety of paracetamol for patients of all ages by adding evidence to the body of knowledge on the changing risks of paracetamol toxicity in ageing, frailty and non-acute exposures, and the potential for lifespan and healthspan increasing interventions to provide novel mechanisms of paracetamol hepatotoxicity protection. Furthermore, this thesis aimed to investigate the potential of both paracetamol, and lifespan and healthspan interventions in delaying or preventing frailty. Overall the work presented in this thesis used a series of mouse mo

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Osei-Mensah, Marian. "Synthesis of Resveratrol Ester Derivatives Using Selective Enzymatic Hydrolysis." Digital Commons @ East Tennessee State University, 2011. https://dc.etsu.edu/etd/1400.

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Resveratrol, a naturally derived stilbene, is an interesting compound mostly talked about recently because for its anti-cancer properties. Unfortunately it has some shortcomings due to its low bioavailability and low solubility in water. For this reason, my research is to overcome resveratrol's drawbacks by improving its bioavailability and hydrophilicity. My research is focused on syntheses of novel derivatives of resveratrol such as 3, 5-di-O-isobutyroyl resveratrol and 3, 5-di-O-hexanoyl resveratrol using lipase catalyzed hydrolysis. Therefore, the tri-acylated resveratrols 3, 5, 4'-tri-O-i

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Rigo, Victor Henrique Bittar. "Influência do resveratrol na qualidade e na fertilidade do espermatozoide suíno refrigerado entre 15-17°C por 72 horas para inseminação artificial intrauterina." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/10/10131/tde-21032017-093141/.

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A preservação do sêmen suíno refrigerado para fins de inseminação artificial é a forma mais utilizada no mundo. Para tal, os espermatozoides são diluídos em meios que forneçam substratos para nutrir e proteger estas células. Porém, a faixa de temperatura de armazenamento do sêmen suíno refrigerado não é capaz de cessar completamente os mecanismos metabólicos dos espermatozoides, que em ambiente aeróbico da dose inseminante, produzem e liberam continuamente produtos do metabolismo do oxigênio. A ação das espécies reativas de oxigênio sobre o espermatozoide é uma das razões do declínio na popul

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Ibrahim, Haytham. "Resveratrol; Does it have a cardiovascular protective function? [Resveratrol: A potential cardiovascular protective role]." 2007. http://link.library.utoronto.ca/eir/EIRdetail.cfm?Resources__ID=788676&T=F.

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