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Journal articles on the topic 'Resveratrol'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Zhong, Zixing, Xin Guo, and Yanmei Zheng. "Network Pharmacology-based and Molecular Docking Analysis of Resveratrol’s Pharmacological Effects on Type I Endometrial Cancer." Anti-Cancer Agents in Medicinal Chemistry 22, no. 10 (2022): 1933–44. http://dx.doi.org/10.2174/1871520621666211015140455.

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Background: Resveratrol is a natural polyphenol commonly seen in foods. It has demonstrated an inhibitive effect on endometrial cancer, but the molecular action is still not known. Objective: We aimed to use network pharmacology to systematically study the possible mechanisms of resveratrol’s pharmacological effects on type I endometrial cancer. Methods: Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP) were used to predict resveratrol’s possible target genes. They were then converted to UniProt gene symbols. Simultaneously, type I endometrial cancer-rela

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2

Peng, Han, and Fereidoon Shahidi. "The Effects of Acyl Chain Length on Antioxidant Efficacy of Mono- and Multi-Acylated Resveratrol: A Comparative Assessment." Molecules 27, no. 3 (2022): 1001. http://dx.doi.org/10.3390/molecules27031001.

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Acylated derivatives of the dietary phenolic, resveratrol, were prepared via enzymatic and chemical transesterification modification with selected vinyl fatty acids to expand the potential application of resveratrol and its acylated derivatives in functional supplement, cosmetic/skincare, and pharmaceutical fields. The acylation was implemented using eight vinyl fatty acids with varying chain lengths (C2:0-C18:0). Eight monoesters enzymatically prepared, eight diesters and four triesters, chemically prepared, were isolated and purified and identified via MS (mass spectra) or/and NMR (nuclear m

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3

Jang, Ae-Ra, Jun-Sang Ham, Dong-Wook Kim, et al. "Dietary Supplementation of Resveratrol and Methoxylated Resveratrol Affects on Chicken Thigh Meat Quality." Korean Journal of Poultry Science 38, no. 4 (2011): 315–22. http://dx.doi.org/10.5536/kjps.2011.38.4.315.

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4

Yanagi, Masayoshi, Noriyuki Uchida, and Hiroki Hamada. "Versatile Synthetic Route for Resveratrol Modification via Amine Functionalization." Natural Product Communications 14, no. 9 (2019): 1934578X1987621. http://dx.doi.org/10.1177/1934578x19876210.

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Resveratrol derivatives containing a primary amine functional group were synthesized by an introduction of N-Boc-bromoethylamine to resveratrol using Williamson ether synthesis and subsequent deprotection of the Boc group with trifluoroacetic acid. After conjugation of fluorescent NBD-F or rhodamine B with isothiocyanate (Rhd B-ITC) using the amine group, resveratrols modified with NBD or Rhd B (Resveratrol-NBD and Resveratrol-Rhd B, respectively) were successfully obtained.

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5

Andreato, Camilla Cavasin, Adriana Kulpe, Waleria Christiane Rezende Fett, and Carlos Alexandre Fett. "The use of resveratrol in the fight against Cancer in women: a review." Brazilian Journal of Health Review 7, no. 4 (2024): e72231. http://dx.doi.org/10.34119/bjhrv7n4-391.

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Cancer continues to be a major global health challenge, especially among women. Recent scientific studies have focused on resveratrol (RSV), a natural polyphenol found in various foods, as a potential supplementary therapy for cancer. This review assesses the existing evidence on resveratrol's effects on cancer cells, examining its mechanisms, potential benefits, and clinical implications. Research involved analyzing articles sourced from PUBMED with keywords: "(resveratrol) AND (cancer) AND (women)" (197 articles), "(resveratrol) AND (ovarian cancer)" (149 articles), and "(resveratrol) AND (e

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6

Alquisiras-Burgos, Iván, Irma Gabriela González-Herrera, Sergio Alcalá-Alcalá, and Penélope Aguilera. "Nose-to Brain Delivery of Resveratrol, a Non-Invasive Method for the Treatment of Cerebral Ischemia." Drugs and Drug Candidates 3, no. 1 (2024): 102–25. http://dx.doi.org/10.3390/ddc3010007.

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Cerebral ischemia represents a particular condition among neurological diseases due to its high frequency, high associated mortality, and the permanent disability in patients that survive it. Numerous studies in animal models have demonstrated the protective properties of resveratrol against cerebral ischemia. Resveratrol is a soluble molecule in polar solvents with high membrane permeability; however, it is rapidly metabolized at the liver and is also a substrate of the ATP binding cassette transporters located at the blood–brain barrier. These circumstances reduced bioavailability of resvera

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7

Novakovic, Radmila, Nebojsa Radunovic, Jovana Rajkovic, et al. "Wine polyphenol resveratrol inhibits contractions of isolated rat uterus by activation of smooth muscle inwardly rectifying potassium channels." Veterinarski glasnik 70, no. 3-4 (2016): 121–29. http://dx.doi.org/10.2298/vetgl1604121n.

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Resveratrol is a phytoalexin produced in a number of plant species including grapes. The benefit of resveratrol to health is widely reported. Resveratrol has been found to promote relaxation of non-pregnant and pregnant uterus, but its mechanism of action is unclear. The aims of our study were to investigate the involvement of inwardly rectifying potassium channels (Kir) in inhibitory effects of resveratrol on three models of contractions of non-pregnant rat uterus: the spontaneous rhythmic contractions (SRC), oxytocin-elicited phasic contractions and tonic oxytocin-elicited contractions.Uteri

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8

Luís, Ângelo, Helena Marcelino, Fernanda Domingues, Luísa Pereira, and José Francisco Cascalheira. "Therapeutic Potential of Resveratrol for Glioma: A Systematic Review and Meta-Analysis of Animal Model Studies." International Journal of Molecular Sciences 24, no. 23 (2023): 16597. http://dx.doi.org/10.3390/ijms242316597.

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Gliomas are aggressive malignant brain tumors, with poor prognosis despite available therapies, raising the necessity for finding new compounds with therapeutic action. Numerous preclinical investigations evaluating resveratrol’s anti-tumor impact in animal models of glioma have been reported; however, the variety of experimental circumstances and results have prevented conclusive findings about resveratrol’s effectiveness. Several databases were searched during May 2023, ten publications were identified, satisfying the inclusion criteria, that assess the effects of resveratrol in murine gliom

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9

Boo, Yong Chool. "Human Skin Lightening Efficacy of Resveratrol and Its Analogs: From in Vitro Studies to Cosmetic Applications." Antioxidants 8, no. 9 (2019): 332. http://dx.doi.org/10.3390/antiox8090332.

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Antioxidants are deemed useful in controlling oxidative stress associated with extrinsic skin aging and pigmentation disorders. Resveratrol is a polyphenol compound found in many edible plants such as Vitis vinifera, and its inhibitory effects on the catalytic activity, gene expression, and posttranslational modifications of tyrosinase, a key enzyme in the melanin biosynthetic pathway, provide a mechanistic basis for its antimelanogenic effects seen in melanocytic cells, three-dimensionally reconstituted skin models, and in vivo animal models. As a potent antioxidant and a modulator of nuclear

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10

Farhan, Mohd, and Asim Rizvi. "The Pharmacological Properties of Red Grape Polyphenol Resveratrol: Clinical Trials and Obstacles in Drug Development." Nutrients 15, no. 20 (2023): 4486. http://dx.doi.org/10.3390/nu15204486.

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Resveratrol is a stilbenoid from red grapes that possesses a strong antioxidant activity. Resveratrol has been shown to have anticancer activity, making it a promising drug for the treatment and prevention of numerous cancers. Several in vitro and in vivo investigations have validated resveratrol’s anticancer capabilities, demonstrating its ability to block all steps of carcinogenesis (such as initiation, promotion, and progression). Additionally, resveratrol has been found to have auxiliary pharmacological effects such as anti-inflammatory, cardioprotective, and neuroprotective activity. Desp

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11

Chen, Xiangxiu, Xu Song, Xinghong Zhao, et al. "Insights into the Anti-inflammatory and Antiviral Mechanisms of Resveratrol." Mediators of Inflammation 2022 (August 12, 2022): 1–11. http://dx.doi.org/10.1155/2022/7138756.

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Resveratrol is a naturally occurring stilbene phytoalexin phenolic compound, which has been extensively studied on its biological activity. It has been widely accepted that resveratrol possesses anti-inflammatory and antiviral activities. In this review, we summarize the anti-inflammatory dosages and mechanism and antiviral mechanism of resveratrol. Since viral infections are often accompanied by inflammation, we propose that the NF-κB signaling pathway is a key and common molecular mechanism of resveratrol to exert anti-inflammatory and antiviral effects. For future studies, we believe that r

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Lin, Jian, Xican Li, Ban Chen, Gang Wei, and Dongfeng Chen. "E-Configuration Improves Antioxidant and Cytoprotective Capacities of Resveratrols." Molecules 23, no. 7 (2018): 1790. http://dx.doi.org/10.3390/molecules23071790.

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The antioxidant and cytoprotective capacities of E-resveratrol and Z-resveratrol were compared using chemical and cellular assays. Chemical assays revealed that the two isomers were dose-dependently active in •O2−-scavenging, ferric reducing antioxidant power (FRAP), Cu2+-reducing antioxidant capacity (CUPRAC), 2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl 3-oxide radical (PTIO•)-scavenging (pH 7.4 and pH 4.5), and 1,1-diphenyl-2-picryl-hydrazyl (DPPH•)-scavenging assays. The cellular assay indicated that the two isomers could also increase cell viabilities. However, quantitative analyses sug

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13

Wang, Nasui, Seung-Hyun Ko, Weidong Chai та ін. "Resveratrol recruits rat muscle microvasculature via a nitric oxide-dependent mechanism that is blocked by TNFα". American Journal of Physiology-Endocrinology and Metabolism 300, № 1 (2011): E195—E201. http://dx.doi.org/10.1152/ajpendo.00414.2010.

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Resveratrol, a polyphenol found in many plants, has antioxidant and anti-inflammatory actions. It also improves endothelial function and may be cardioprotective. Tumor necrosis factor-α (TNFα) causes oxidative stress and microvascular endothelial dysfunction. Whether resveratrol affects microvascular function in vivo and, if so, whether inflammatory cytokines antagonize its microvascular action are not clear. In cultured bovine aortic endothelial cells (BAECs), reserveratrol (100 nM) increased the phosphorylation of protein kinase B (Akt), endothelial nitric oxide (NO) synthase (eNOS), and ERK

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14

Bissacotti, Bianca Fagan, Marcylene Vieira da Silveira, Charles Elias Assmann, et al. "Resveratrol Alleviates Inflammatory Response Through P2X7/NLRP3 Signaling Pathway: In Silico and In Vitro Evidence from Activated Microglia." Pharmaceuticals 18, no. 7 (2025): 950. https://doi.org/10.3390/ph18070950.

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Background/Objectives: Chronic inflammation and inappropriate NLRP3 inflammasome regulation are related to many brain diseases. Purinergic mediators may play an important role in inflammation regulation and could be targeted for effective therapies for these illnesses. We evaluated resveratrol’s anti-neuroinflammatory potential in BV-2 microglia cells using an innovative in vitro method of NLRP3 inflammasome activation, correlating with the P2X7 purinergic receptor. Methods: In silico analyses were used to estimate resveratrol’s interaction with NLRP3, and its cytotoxicity was measured for 24,

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15

Pignet, Anna-Lisa, Marlies Schellnegger, Andrzej Hecker, Michael Kohlhauser, Petra Kotzbeck, and Lars-Peter Kamolz. "Resveratrol-Induced Signal Transduction in Wound Healing." International Journal of Molecular Sciences 22, no. 23 (2021): 12614. http://dx.doi.org/10.3390/ijms222312614.

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Resveratrol is a well-known polyphenol that harbors various health benefits. Besides its well-known anti-oxidative potential, resveratrol exerts anti-inflammatory, pro-angiogenic, and cell-protective effects. It seems to be a promising adjuvant for various medical indications, such as cancer, vascular, and neurodegenerative diseases. Additionally, resveratrol was shown to display beneficial effects on the human skin. The polyphenol is discussed to be a feasible treatment approach to accelerate wound healing and prevent the development of chronic wounds without the drawback of systemic side eff

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16

Ge, Hailong, Lujia Si, Chen Li, et al. "The Antidepressant Effect of Resveratrol Is Related to Neuroplasticity Mediated by the ELAVL4-Bdnf mRNA Pathway." International Journal of Molecular Sciences 26, no. 3 (2025): 1113. https://doi.org/10.3390/ijms26031113.

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Resveratrol, a plant-derived polyphenol, exhibits significant antidepressant effects and notably enhances neuroplasticity in neurological diseases. However, whether the antidepressant function of resveratrol is related to neuroplasticity remains uncertain, and the underlying mechanisms is poorly understood. This study aims to investigate the role and mechanism of resveratrol in neuroplasticity in depression. Here, we adopted the chronic unpredictable mild stress (CUMS) model and resveratrol intervention by oral gavage. Thereafter, behavioral tests confirmed resveratrol’s antidepressant effect,

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17

Valenzuela, Hector F., Giovanni Samayoa, Kassandra Martinez, and Samantha Salvador. "Resveratrol, Modafinil and Caffeine’s modulation of B cell’s CD19 activation receptor." Journal of Immunology 208, no. 1_Supplement (2022): 122.29. http://dx.doi.org/10.4049/jimmunol.208.supp.122.29.

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Abstract Resveratrol a natural compound with anti-oxidant properties shown to inhibit cell proliferation and induces cellular apoptosis in Jurkat cell lines. Mechanistically, it was observed that interleukin-2 expression was blocked in T cells, suggesting resveratrol’s anti-inflammatory mechanism may involve downregulation of activation molecules. In this study, we investigated the effects of resveratrol or in combination with Modafinil or caffeine on a B cell line, Nor20. Modafinil is a compound shown to directly act on enzymes in the brain’s free-radical scavenging system and therefore direc

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18

Căpruciu, Ramona. "Resveratrol in Grapevine Components, Products and By-Products—A Review." Horticulturae 11, no. 2 (2025): 111. https://doi.org/10.3390/horticulturae11020111.

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Resveratrol, a valuable compound found in grapevines, is found in significant amounts in grapes and wine, but also in other parts of the plant (leaves, roots, shoots) and derived products (juice, raisins, powders, grape pomace). Synthesis factors considerably influence the resveratrol content, and research aims to optimise these factors to maximise yield, with applications in agriculture, food, cosmetics, and medicine. This literature survey aims to review and synthesise existing knowledge on aspects of resveratrol’s chemical structure and isomers, biological properties, and the factors influe

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Chang, Huai-Chia, Tyng-Guey Chen, Yu-Ting Tai, Ta-Liang Chen, Wen-Ta Chiu, and Ruei-Ming Chen. "Resveratrol Attenuates Oxidized LDL-Evoked Lox-1 Signaling and Consequently Protects against Apoptotic Insults to Cerebrovascular Endothelial Cells." Journal of Cerebral Blood Flow & Metabolism 31, no. 3 (2010): 842–54. http://dx.doi.org/10.1038/jcbfm.2010.180.

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Cerebrovascular endothelial cells (CECs) are crucial components of the blood—brain barrier. Our previous study showed that oxidized low-density lipoprotein (oxLDL) induces apoptosis of CECs. This study was designed to further evaluate the effects of resveratrol on oxLDL-induced CEC insults and its possible molecular mechanisms. Resveratrol decreased the oxidation of LDL into oxLDL. Additionally, the oxLDL-caused oxidative stress and cell damage were attenuated by resveratrol. Exposure of CECs to oxLDL induced cell shrinkage, DNA fragmentation, and cell apoptosis, but resveratrol defended again

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20

Yalçın, Rıza, Asım Kart, Özlem Özmen, and Esra Zeybek. "Protective effects of resveratrol against fumonisin B1-induced liver toxicity in mice." Archives of Industrial Hygiene and Toxicology 74, no. 2 (2023): 115–19. http://dx.doi.org/10.2478/aiht-2023-74-3648.

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Abstract The aim of this study was to investigate the effects of resveratrol against fumonisin B1 (FB1)-induced liver toxicity, as, to the best of our knowledge, these effects have not been investigated yet, even though the toxic effects and mechanisms of FB1 and the antioxidative effects of resveratrol are well known. 40 BALB/c mice were divided into control, FB1, resveratrol, and FB1+resveratrol groups. Control received saline for 14 days. The FB1 group received 2.25 mg/kg FB1 every other day for 14 days. The resveratrol group received 10 mg/kg resveratrol for 14 days. The FB1+resveratrol gr

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Szymkowiak, Izabela, Malgorzata Kucinska, and Marek Murias. "Between the Devil and the Deep Blue Sea—Resveratrol, Sulfotransferases and Sulfatases—A Long and Turbulent Journey from Intestinal Absorption to Target Cells." Molecules 28, no. 8 (2023): 3297. http://dx.doi.org/10.3390/molecules28083297.

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For nearly 30 years, resveratrol has attracted the scientific community’s interest. This has happened thanks to the so-called French paradox, that is, the paradoxically low mortality from cardiovascular causes in the French population despite a diet rich in saturated fat. This phenomenon has been linked to the consumption of red wine, which contains a relatively high level of resveratrol. Currently, resveratrol is valued for its versatile, beneficial properties. Apart from its anti-atherosclerotic activity, resveratrol’s antioxidant and antitumor properties deserve attention. It was shown that

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Y. Mohammed, Zainab, Essam F. Al-Jumaily, and Nahi Y. Yaseen. "In Vitro Cytotoxic Study for Purified Resveratrol Extracted from Grape Skin Fruit Vitis vinifera." Iraqi Journal of Pharmaceutical Sciences ( P-ISSN: 1683 - 3597 , E-ISSN : 2521 - 3512) 18, Suppl. (2017): 19–25. http://dx.doi.org/10.31351/vol18isssuppl.pp19-25.

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 This study was conducted with the aim to extract and purify a polyphenolic compound â€œ Resveratrolâ€ from the skin of black grapes Vitis vinifera cultivated in Iraq. The purified resveratrol is obtained after ethanolic extraction with 80% v/v solution for fresh grape skin, followed by acid hydrolysis with 10% HCl solution then the aglycon moiety was taken with organic solvent ( chloroform). Using silica gel G60 packed glass column chromatography with mobile phase benzene: methanol: acetic acid 20:4:1 a partial purified resveratrol was obtained then preperative thin layer chromat

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Xiao, Zijian, Qing Ye, Xiaomei Duan, and Tao Xiang. "Network Pharmacology Reveals That Resveratrol Can Alleviate COVID-19-Related Hyperinflammation." Disease Markers 2021 (September 22, 2021): 1–12. http://dx.doi.org/10.1155/2021/4129993.

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Hyperinflammation is related to the development of COVID-19. Resveratrol is considered an anti-inflammatory and antiviral agent. Herein, we used a network pharmacological approach and bioinformatic gene analysis to explore the pharmacological mechanism of Resveratrol in COVID-19 therapy. Potential targets of Resveratrol were obtained from public databases. SARS-CoV-2 differentially expressed genes (DEGs) were screened out via bioinformatic analysis Gene Expression Omnibus (GEO) datasets GSE147507, followed by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichm

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WM*, Dos Santos. "Resveratrol’s Action against Viral Infections." Advances in Pharmacology and Clinical Trials 9, no. 2 (2024): 1–3. http://dx.doi.org/10.23880/apct-16000236.

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The biological activity of resveratrol (3,5,4’-trihydroxy-trans-stilbene) has been the subject of extensive study in the treatment of various diseases due to its anti-inflammatory, antioxidant and anticancer activities, as well as its minimal toxicity and side effects. It has been widely accepted that resveratrol also has antiviral activities. In this mini-review, we summarize resveratrol’s antiviral mechanisms. Since viral infections are often accompanied by inflammation, the TLRs/NF-κB signaling pathways are key and common molecular mechanisms for resveratrol to exert anti-inflammatory and a

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Sebori, Rio, Atsushi Kuno, Ryusuke Hosoda, Takashi Hayashi, and Yoshiyuki Horio. "Resveratrol Decreases Oxidative Stress by Restoring Mitophagy and Improves the Pathophysiology of Dystrophin-Deficient mdx Mice." Oxidative Medicine and Cellular Longevity 2018 (October 29, 2018): 1–13. http://dx.doi.org/10.1155/2018/9179270.

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We previously showed that treatment with resveratrol (3,5,4′-trihydroxy-trans-stilbene), an activator of the NAD+-dependent deacetylase SIRT1 at 4 g/kg food for 32 weeks, significantly decreased the muscular reactive oxygen species (ROS) levels and ameliorated the pathology of mdx mice, an animal model of Duchenne muscular dystrophy (DMD). Here, we treated mdx mice with various doses of resveratrol (0.04, 0.4, and 4 g/kg food) for 56 weeks and examined the effects on serum creatine kinase levels and physical activities. Because resveratrol promotes autophagy, we also investigated whether autop

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Bowers, Jennifer L., Valentyn V. Tyulmenkov, Sarah C. Jernigan та Carolyn M. Klinge. "Resveratrol Acts as a Mixed Agonist/Antagonist for Estrogen Receptors α and β*". Endocrinology 141, № 10 (2000): 3657–67. http://dx.doi.org/10.1210/endo.141.10.7721.

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Abstract Epidemiological evidence indicates that phytoestrogens inhibit cancer formation and growth, reduce cholesterol levels, and show benefits in treating osteoporosis. At least some of these activities are mediated through the interaction of phytoestrogens with estrogen receptors α and β (ERα and ERβ). Resveratrol, trans-3,5,4′-trihydroxystilbene, is a phytoestrogen in grapes that is present in red wine. Resveratrol was shown to bind ER in cytosolic extracts from MCF-7 and rat uteri. However, the contribution of ERα vs. ERβ in this binding is unknown. Here we report that resveratrol binds

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Synowiec-Wojtarowicz, Agnieszka, Agata Krawczyk, and Magdalena Kimsa-Dudek. "The Effect of Resveratrol and Static Magnetic Field Interactions on the Oxidation–Reduction Parameters of Melanoma Malignant Cells." Applied Sciences 13, no. 14 (2023): 8042. http://dx.doi.org/10.3390/app13148042.

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Background: Scientific research has confirmed the biological activity of resveratrol, which includes its antioxidant, anti-inflammatory, cardioprotective and anticancer properties. There is no known interaction between a static magnetic field and resveratrol that can modulate resveratrol’s effect on cells. Thus, the main aim of our research was to assess the effect of the co-exposure to resveratrol and a static magnetic field on the oxidation–reduction homeostasis of C32 and Colo829 melanoma cells. Methods: The studies consisted of determining the activity of the antioxidant enzymes that const

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Chai, Mei, Xuyan Tang, Jinzhong Zhang, and Chenchen Huang. "Resveratrol in Periodontitis Treatment: Efficacy and Mechanism of Action in Rat Models and its Clinical Implications." Current Topics in Nutraceutical Research 22, no. 2 (2024): 452–58. http://dx.doi.org/10.37290/ctnr2641-452x.22:452-458.

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Periodontitis, a prevalent periodontal disease, serves as the foundation for numerous periodontal pathologies. The current study aimed to examine the adjunctive role of resveratrol in treating periodontitis. Our findings reveal that resveratrol significantly augments periodontal health of patients, indicating its substantial efficacy. Further experimentation involving the construction of a rat model of periodontitis demonstrated that resveratrol effectively mitigates periodontal tissue damage and inhibits apoptosis in periodontal cells. This confirms resveratrol's promising clinical applicabil

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Wu, Hong, Liang Chen, Feifei Zhu, Xu Han, Lindan Sun, and Keping Chen. "The Cytotoxicity Effect of Resveratrol: Cell Cycle Arrest and Induced Apoptosis of Breast Cancer 4T1 Cells." Toxins 11, no. 12 (2019): 731. http://dx.doi.org/10.3390/toxins11120731.

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Resveratrol, a natural polyterpenoid, can scavenge reactive oxygen species in vivo to carry out the functions of antioxidation and antiaging. Resveratrol’s anti-cancer capability has attracted widespread attention, but its molecular mechanism has not been systematically explained. In this study, by comparing the activity of normal cell lines and cancer cell lines after treating with resveratrol, it was found that resveratrol has more significant cytotoxicity in cancer cell lines. Resveratrol could play a toxic role through inducing apoptosis of the cancer cell in a time- and concentration-depe

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NADERALI, Ebrahim K., Patrick J. DOYLE, and Gareth WILLIAMS. "Resveratrol induces vasorelaxation of mesenteric and uterine arteries from female guinea-pigs." Clinical Science 98, no. 5 (2000): 537–43. http://dx.doi.org/10.1042/cs0980537.

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Naturally occurring hydroxystilbenes have been shown to induce vasorelaxation. Here, we studied the mechanism of resveratrol-induced vasorelaxation in different types of blood vessels, namely mesenteric (resistance) and main uterine (conductance) arteries, from female guinea-pigs on day 7 and day 15 of the oestrous cycle. Resveratrol (5–70 µmol/l) induced concentration-dependent relaxation of both mesenteric and uterine arteries preconstricted with either noradrenaline (NA; 10 µmol/l) or KCl (125 mmol/l). Resveratrol was 2-fold more potent in inducing relaxation of mesenteric arteries than of

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Kobylka, Paulina, Malgorzata Kucinska, Jacek Kujawski, Dawid Lazewski, Marcin Wierzchowski, and Marek Murias. "Resveratrol Analogues as Selective Estrogen Signaling Pathway Modulators: Structure–Activity Relationship." Molecules 27, no. 20 (2022): 6973. http://dx.doi.org/10.3390/molecules27206973.

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Resveratrol is a plant-derived phytoalexin found in grapes, red wine and many other plants used in Asian folk medicine. It is extensively studied for pleiotropic biological activity. The most crucial are anticancer and chemopreventive properties. Resveratrol has also been reported to be an antioxidant and phytoestrogen. The phytoestrogenic activity of resveratrol was assayed in different in vitro and in vivo models. Although these works brought some, on the first look, conflicting results, it is commonly accepted that resveratrol interacts with estrogen receptors and functions as a mixed agoni

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Shin, Jung-Won, Hyun-Sun Lee, Jung-Im Na, Chang-Hun Huh, Kyung-Chan Park, and Hye-Ryung Choi. "Resveratrol Inhibits Particulate Matter-Induced Inflammatory Responses in Human Keratinocytes." International Journal of Molecular Sciences 21, no. 10 (2020): 3446. http://dx.doi.org/10.3390/ijms21103446.

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Particulate matter (PM), a major air pollutant, is a complex mixture of solid and liquid particles of various sizes. PM has been demonstrated to cause intracellular inflammation in human keratinocytes, and is associated with various skin disorders, including atopic dermatitis, eczema, and skin aging. Resveratrol is a natural polyphenol with strong antioxidant properties, and its beneficial effects against skin changes due to PM remain elusive. Therefore, in the present study, we investigated the effect of resveratrol on PM-induced skin inflammation and attempted to deduce the molecular mechani

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Feng, Zeming, Zhengrong Yang, Xiang Gao, Yuhua Xue, and Xiaohui Wang. "Resveratrol Promotes HIV-1 Tat Accumulation via AKT/FOXO1 Signaling Axis and Potentiates Vorinostat to Antagonize HIV-1 Latency." Current HIV Research 19, no. 3 (2021): 238–47. http://dx.doi.org/10.2174/1570162x19666210118151249.

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Background: The latent reservoir of HIV-1 is a major barrier to achieving the eradication of HIV-1/AIDS. One strategy is termed “shock and kill”, which aims to awaken the latent HIV-1 using latency reversing agents (LRAs) to replicate and produce HIV-1 particles. Subsequently, the host cells containing HIV-1 can be recognized and eliminated by the immune response and anti-retroviral therapy. Although many LRAs have been found and tested, their clinical trials were dissatisfactory. Objective: To aim of the study was to investigate how resveratrol reactivates silent HIV-1 transcription and asses

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Gowd, Vemana, Qingzheng Kang, Qi Wang, Qiang Wang, Feng Chen, and Ka-Wing Cheng. "Resveratrol: Evidence for Its Nephroprotective Effect in Diabetic Nephropathy." Advances in Nutrition 11, no. 6 (2020): 1555–68. http://dx.doi.org/10.1093/advances/nmaa075.

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ABSTRACT Diabetic nephropathy (DN) is a severe complication of diabetes mellitus (DM). Dietary habits play a major role in determining the onset and progression of DM-related disorders and a proper diet (rich in fruits and vegetables) can delay or prevent the process of DM pathogenesis. Thus, increasing attention has been paid to polyphenols and polyphenol-rich foods since their increased intake has been associated with a reduced incidence of DM and its associated complications. Resveratrol is a polyphenolic phytoalexin that is mainly found in grapevines and berries. It is available in various

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Ribeiro, Eduarda, and Nuno Vale. "The Role of Resveratrol in Cancer Management: From Monotherapy to Combination Regimens." Targets 2, no. 4 (2024): 307–26. http://dx.doi.org/10.3390/targets2040018.

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Resveratrol, a naturally occurring polyphenol found in grapes, berries, and peanuts, has garnered significant attention for its potential anti-cancer properties. This review provides a comprehensive analysis of its role in cancer therapy, both as a standalone treatment and in combination with other therapeutic approaches. This review explores the molecular mechanisms underlying resveratrol’s anti-cancer effects, including its antioxidant activity, modulation of cellular signaling pathways, antiproliferative properties, anti-inflammatory effects, and epigenetic influences. This review also exam

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Silva, Paula, María P. Portillo, and Alfredo Fernández-Quintela. "Resveratrol and Wine: An Overview of Thirty Years in the Digital News." International Journal of Environmental Research and Public Health 19, no. 23 (2022): 15815. http://dx.doi.org/10.3390/ijerph192315815.

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Background: Resveratrol’s health benefits have received wide media coverage. Since resveratrol is usually associated with wine, informative texts about it should be prepared very carefully, since inaccurate website content could easily change people’s wine consumption behavior. This study aimed to assess the quality of informative texts related to resveratrol on science journalism websites. Methods: We analyzed 125 resveratrol posts on Science Daily, WebMD, and EurekAlert! published between 1990 and 2020. Results: A higher number of posts was published in the years in which the number of peopl

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Gong, Wei, Peng Sun, Xiujing Li, et al. "Investigating the Molecular Mechanisms of Resveratrol in Treating Cardiometabolic Multimorbidity: A Network Pharmacology and Bioinformatics Approach with Molecular Docking Validation." Nutrients 16, no. 15 (2024): 2488. http://dx.doi.org/10.3390/nu16152488.

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Background: Resveratrol is a potent phytochemical known for its potential in treating cardiometabolic multimorbidity. However, its underlying mechanisms remain unclear. Our study systematically investigates the effects of resveratrol on cardiometabolic multimorbidity and elucidates its mechanisms using network pharmacology and molecular docking techniques. Methods: We screened cardiometabolic multimorbidity-related targets using the OMIM, GeneCards, and DisGeNET databases, and utilized the DSigDB drug characterization database to predict resveratrol’s effects on cardiometabolic multimorbidity.

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Chhabra, Gagan, Chandra K. Singh, Deeba Amiri, Neha Akula, and Nihal Ahmad. "Recent Advancements on Immunomodulatory Mechanisms of Resveratrol in Tumor Microenvironment." Molecules 26, no. 5 (2021): 1343. http://dx.doi.org/10.3390/molecules26051343.

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Immunomodulation of the tumor microenvironment is emerging as an important area of research for the treatment of cancer patients. Several synthetic and natural agents are being investigated for their ability to enhance the immunogenic responses of immune cells present in the tumor microenvironment to impede tumor cell growth and dissemination. Among them, resveratrol, a stilbenoid found in red grapes and many other natural sources, has been studied extensively. Importantly, resveratrol has been shown to possess activity against various human diseases, including cancer. Mechanistically, resvera

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Angelov, George, Lubomir Boyadzhiev, and Silviya Georgieva. "Useful Bioactive Substances from Wastes: Recovery of Trans-Resveratrol from Grapevine Stems." Open Chemical Engineering Journal 10, no. 1 (2016): 4–9. http://dx.doi.org/10.2174/1874123101610010004.

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The methods for producing natural resveratrol are of big interest because of the many health benefits of this substance and its increasing use in functional foods, food supplements and para-pharmaceutical preparations. Generally, resveratrol is extracted from different natural sources, most of them usually produced for consumption purposes (grapes, nuts). This paper presents a method for recovery of resveratrol from a widely available raw material - grapevine stems, a by-product of vine pruning. An efficient extraction-fractionation scheme is developed, based on shifting the phase equilibrium,

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Li, Yuexin. "A Systematic Review of Application of Resveratrol and the Recent Progress of the Drug Delivery System." BIO Web of Conferences 124 (2024): 02019. http://dx.doi.org/10.1051/bioconf/202412402019.

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Background: Resveratrol is a natural compound in plants like grapes and peanuts, it’s an antioxidant used in supplements and medicine. It’s a colorless crystal soluble in organic solvents, with poor water solubility but high cell membrane permeability. It exists in cis and trans forms. Objective: To explore the background of resveratrol, this review comprehensively summarizes the recent advances in resveratrol including its application in cancer, type-2 diabetes mellitus, vascular disease, and the delivery system. Data sources: We performed a narrative review, based on relevant articles writte

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Zakaria, Soha S., and Safaa M. Hanafy. "Unraveling the Beneficial Role of Resveratrol in Fructose-Induced Non-Alcoholic Steatohepatitis with a Focus on the AMPK/Nrf2 Signaling Axis." Medicina 61, no. 1 (2025): 139. https://doi.org/10.3390/medicina61010139.

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Background and Objectives: High fructose intake is associated with non-alcoholic fatty liver disease (NAFLD), a chronic liver disease that is on the rise worldwide. New alternatives for treatment, such as bioactive phytochemicals, are needed. The aim of this study was to investigate the beneficial role of resveratrol in treating non-alcoholic steatohepatitis (NASH). Materials and Methods: Sixty male albino rats were allocated to three groups: group I, the normal control group; group II, the fructose-enriched diet group (FED), which was fed a 70% fructose diet for six weeks to induce NASH; and

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Tseilikman, Vadim E., Olga B. Tseilikman, Vadim A. Shevyrin, et al. "Unraveling the Liver–Brain Axis: Resveratrol’s Modulation of Key Enzymes in Stress-Related Anxiety." Biomedicines 12, no. 9 (2024): 2063. http://dx.doi.org/10.3390/biomedicines12092063.

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Stress-related anxiety disorders and anxiety-like behavior in post-traumatic stress disorder (PTSD) are associated with altered neurocircuitry pathways, neurotransmitter systems, and the activities of monoamine and glucocorticoid-metabolizing enzymes. Resveratrol, a natural polyphenol, is recognized for its antioxidant, anti-inflammatory, and antipsychiatric properties. Previous studies suggest that resveratrol reduces anxiety-like behavior in animal PTSD models by downregulating key enzymes such as 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1) and monoamine oxidases (MAOs). However, the

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Brown, Karen, Despoina Theofanous, Robert G. Britton, et al. "Resveratrol for the Management of Human Health: How Far Have We Come? A Systematic Review of Resveratrol Clinical Trials to Highlight Gaps and Opportunities." International Journal of Molecular Sciences 25, no. 2 (2024): 747. http://dx.doi.org/10.3390/ijms25020747.

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Resveratrol has long been proposed as being beneficial to human health across multiple morbidities, yet there is currently no conclusive clinical evidence to advocate its recommendation in any healthcare setting. A large cohort with high-quality clinical data and clearly defined biomarkers or endpoints are required to draw meaningful conclusions. This systematic review compiles every clinical trial conducted using a defined dose of resveratrol in a purified form across multiple morbidities to highlight the current ‘state-of-play’ and knowledge gaps, informing future trial designs to facilitate

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Briskey, David, and Amanda Rao. "Trans-Resveratrol Oral Bioavailability in Humans Using LipiSperse™ Dispersion Technology." Pharmaceutics 12, no. 12 (2020): 1190. http://dx.doi.org/10.3390/pharmaceutics12121190.

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Resveratrol is a naturally produced compound that has been well researched for its potential health benefits. The primary hindrance towards resveratrol’s therapeutic efficacy is its traditionally poor oral bioavailability. LipiSperse® is a novel delivery system designed to increase the dispersion of lipophilic ingredients, like resveratrol, in aqueous environments. This single-dose, double-blind, randomized study compared the pharmacokinetics of a commercially available resveratrol with (Veri-Sperse®) and without (Veri-te) the LipiSperse® delivery complex. Healthy adults randomly received a si

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Zhang, Hanrui, Brandon Morgan, Barry J. Potter, et al. "Resveratrol improves left ventricular diastolic relaxation in type 2 diabetes by inhibiting oxidative/nitrative stress: in vivo demonstration with magnetic resonance imaging." American Journal of Physiology-Heart and Circulatory Physiology 299, no. 4 (2010): H985—H994. http://dx.doi.org/10.1152/ajpheart.00489.2010.

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Resveratrol is a natural phytophenol that exhibits cardioprotective effects. This study was designed to elucidate the mechanisms by which resveratrol protects against diabetes-induced cardiac dysfunction. Normal control ( m-Lepr db) mice and type 2 diabetic ( Lepr db) mice were treated with resveratrol orally for 4 wk. In vivo MRI showed that resveratrol improved cardiac function by increasing the left ventricular diastolic peak filling rate in Lepr db mice. This protective role is partially explained by resveratrol's effects in improving nitric oxide (NO) production and inhibiting oxidative/n

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Abidin, Nurdiana Zainol, Cheong Hwa Ooi, Kazunori Nosaka, Vishanth Rathakrishnan, Siok Yee Chan, and Noor Khairiah A Karim. "Effects of Resveratrol Supplementation on Delayed Onset Muscle Soreness and Muscle Recovery: A Systematic Review." Malaysian Journal of Medical Sciences 31, no. 6 (2024): 77–102. https://doi.org/10.21315/mjms2024.31.6.7.

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Delayed onset muscle soreness (DOMS) and impaired muscle recovery significantly affect athletes and recreational exercisers, influencing their performance and training consistency. Resveratrol, a natural polyphenol known for its anti-inflammatory and antioxidant properties, is thought to mitigate these effects, yet its effectiveness remains to be fully verified. This systematic review evaluates the impact of RES supplementation on muscle recovery in adults by examining its influence on DOMS, oxidative stress, and inflammation, along with its interactions with other supplements. Three electroni

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Woodman, Keryn G., Chantal A. Coles, Shireen R. Lamandé, and Jason D. White. "Resveratrol Promotes Hypertrophy in Wildtype Skeletal Muscle and Reduces Muscle Necrosis and Gene Expression of Inflammatory Markers in Mdx Mice." Molecules 26, no. 4 (2021): 853. http://dx.doi.org/10.3390/molecules26040853.

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Duchenne muscular dystrophy (DMD) is a progressive fatal neuromuscular disorder with no cure. Therapies to restore dystrophin deficiency have been approved in some jurisdictions but long-term effectiveness is yet to be established. There is a need to develop alternative strategies to treat DMD. Resveratrol is a nutraceutical with anti-inflammatory properties. Previous studies have shown high doses (100–400 mg/kg bodyweight/day) benefit mdx mice. We treated 4-week-old mdx and wildtype mice with a lower dose of resveratrol (5 mg/kg bodyweight/day) for 15 weeks. Voluntary exercise was used to tes

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Herrera, Daniela P., Andrea M. Chánique, Ascensión Martínez-Márquez, et al. "Rational Design of Resveratrol O-methyltransferase for the Production of Pinostilbene." International Journal of Molecular Sciences 22, no. 9 (2021): 4345. http://dx.doi.org/10.3390/ijms22094345.

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Pinostilbene is a monomethyl ether analog of the well-known nutraceutical resveratrol. Both compounds have health-promoting properties, but the latter undergoes rapid metabolization and has low bioavailability. O-methylation improves the stability and bioavailability of resveratrol. In plants, these reactions are performed by O-methyltransferases (OMTs). Few efficient OMTs that monomethylate resveratrol to yield pinostilbene have been described so far. Here, we report the engineering of a resveratrol OMT from Vitis vinifera (VvROMT), which has the highest catalytic efficiency in di-methylating

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Chin, Yu-Tang, Po-Li Wei, Yih Ho, et al. "Thyroxine inhibits resveratrol-caused apoptosis by PD-L1 in ovarian cancer cells." Endocrine-Related Cancer 25, no. 5 (2018): 533–45. http://dx.doi.org/10.1530/erc-17-0376.

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Thyroid hormone,l-thyroxine (T4), has been shown to promote ovarian cancer cell proliferation via a receptor on plasma membrane integrin αvβ3 and to induce the activation of ERK1/2 and expression of programmed death-ligand 1 (PD-L1) in cancer cells. In contrast, resveratrol binds to integrin αvβ3 at a discrete site and induces p53-dependent antiproliferation in malignant neoplastic cells. The mechanism of resveratrol action requires nuclear accumulation of inducible cyclooxygenase (COX)-2 and its complexation with phosphorylated ERK1/2. In this study, we examined the mechanism by which T4impai

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Ardianto, Chrismawan, Aniek Setiya Budiatin, I. Nengah Budi Sumartha, Nurrahmi Nurrahmi, Mahardian Rahmadi, and Junaidi Khotib. "Resveratrol ameliorates physical and psychological stress-induced depressive-like behavior." Journal of Basic and Clinical Physiology and Pharmacology 32, no. 4 (2021): 335–40. http://dx.doi.org/10.1515/jbcpp-2020-0437.

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Abstract Objectives Depression is a mental disorder that profoundly affects all aspects of life, but currently, antidepressants have some problems with their effectiveness and side effects. Resveratrol is a compound that has the ability to regulate the hypothalamic-pituitary-adrenal axis. This study aimed to determine resveratrol’s effect on physical and psychological stress-induced depressive-like behavior. Methods Mice were divided into control, physical stress, psychological stress groups. Treatment was conducted with fluvoxamine 20 mg/kg and resveratrol 20, 40, and 80 mg/kg for seven days.

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