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Journal articles on the topic 'Reticuline'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Saidi, Nurdin, Hiroshi Morita, Marc Litaudon, Mohd Azlan Naflah, Khalijah Awang, and Mustanir. "New Phenyl Propanoids from Cryptocarya bracteolata." Natural Product Communications 11, no. 6 (2016): 1934578X1601100. http://dx.doi.org/10.1177/1934578x1601100629.

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Two new phenyl propanoids were extracted from the bark of Cryptocarya bracteolate Gamb., ethyl 3-(2′-hydroxy-3′,4′,5′-trimethoxyphenyl) propanoate (1) and ethyl 3-(2′-glucosyl-3′,4′,5′-trimethoxyphenyl)propanoate(2), together with seven known alkaloids, (+)-lirioferine (3), (+)-bracteoline (4), (+)-reticuline (5), (+)-reticulineN-oxide (6), (-)-norargemonine (7), (+)-bisnorargemonine (8) and atherolin (9). The structures of compounds were established through several spectroscopic methods; ID and 2D-NMR, UV, IR and MS.

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2

Yang, Xinyao, Xiaoli Gao, Yuan Cao та ін. "Anti-Inflammatory Effects of Boldine and Reticuline Isolated from Litsea cubeba through JAK2/STAT3 and NF-κB Signaling Pathways". Planta Medica 84, № 01 (2017): 20–25. http://dx.doi.org/10.1055/s-0043-113447.

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AbstractThe anti-inflammatory effects of boldine and reticuline isolated from Litsea cubeba were evaluated by using xylene-induced ear edema and carrageenan-induced paw edema in mice and rats. Our results demonstrated that intragastric administration with boldine and reticuline significantly mitigated ear weight in mice and decreased paw volume in rats. A combination administration of boldine (0.5 mg/kg) + reticuline (0.25 mg/kg) resulted in a potentiated inhibition in these two models. In parallel, boldine or reticuline reduce the infiltration of neutrophil leukocytes in rat paw tissue, respe

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3

Fedurco, Milan, Jana Gregorová, Kristýna Šebrlová, et al. "Modulatory Effects ofEschscholzia californicaAlkaloids on Recombinant GABAAReceptors." Biochemistry Research International 2015 (2015): 1–9. http://dx.doi.org/10.1155/2015/617620.

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The California poppy (Eschscholzia californicaCham.) contains a variety of natural compounds including several alkaloids found exclusively in this plant. Because of the sedative, anxiolytic, and analgesic effects, this herb is currently sold in pharmacies in many countries. However, our understanding of these biological effects at the molecular level is still lacking. Alkaloids detected inE. californicacould be hypothesized to act at GABAAreceptors, which are widely expressed in the brain mainly at the inhibitory interneurons. Electrophysiological studies on a recombinantα1β2γ2GABAAreceptor sh

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4

MARTIN, M. L., J. A. SAGREDO, J. M. MORAIS, M. J. MONTERO, M. T. SANCHEZ, and L. SAN ROMAN. "Uterine inhibitory effect of reticuline." Journal of Pharmacy and Pharmacology 40, no. 11 (1988): 801–2. http://dx.doi.org/10.1111/j.2042-7158.1988.tb05176.x.

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5

Saidi, Nurdin, Hiroshi Morita, Marc Litaudon, Mat Ropi Mukhtar, Khalijah Awang, and A. Hamid A. Hadi. "BENZYLISOQUINOLINE ALKALOIDS FROM BARK OF Cryptocarya rugulosa." Indonesian Journal of Chemistry 11, no. 1 (2011): 59–66. http://dx.doi.org/10.22146/ijc.21421.

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Seven known Benzylisoquinoline alkaloids, Papraline 1, (+)-norcinnamolaurine 2, (+)-codamine 3, (+)-6-methoxy-1-(3'-methoxybenzyl)-N-methyl-7-isoquinolinol 4, (+)-reticuline N-oxide 5, (+)-reticuline 6 and (-)-N-methylisococlaurine 7 were isolated from bark of Cryptocarya rugulosa. A combination of 1D-NMR (1H, 13C, DEPT, NOE), 2D-NMR (COSY, NOESY, HMQC, HMBC), MS (HRESI+, FAB+ and EI) spectroscopy used to elucidate the structure.

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6

Chen, Chien-Kuang, Su-Chang Chen, Chung-Hsiung Chen, and Shoei-Sheng Lee. "Isoquinoline Alkaloids from the Leaves of Dehaasia Hainanensis." Natural Product Communications 2, no. 1 (2007): 1934578X0700200. http://dx.doi.org/10.1177/1934578x0700200115.

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This study was aimed at investigating the alkaloids present in the leaves of Dehaasia hainanensis. Thirteen isoquinolines were isolated and characterized. Of these, four aporphines [(+)-laurolitsine, (+)-corydine, (+)-laurotetanine and (+)-lindcarpine], two morphinans [(-)-sinoacutine and (-)-ocobotrine], four benzylisoquinolines [(+)-reticuline, (+)-roefractine, (+)-reticuline N-oxide, and O-methylarmepavine], and one bisbenzylisoquinoline [(-)-N,N'-dimethyllindoldhamine] are reported for the first time from Dehaasia species. The structures were elucidated by spectral analysis.

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7

I. Meyers, A., and Joseph Guiles. "The Asymmetric Total Synthesis of (+)-Reticuline." HETEROCYCLES 28, no. 1 (1989): 295. http://dx.doi.org/10.3987/com-88-s22.

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8

Rüffer, M. "Enzymatic Formation of Corytuberine from (S)-Reticuline." Planta Medica 56, no. 06 (1990): 599. http://dx.doi.org/10.1055/s-2006-961212.

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9

Jendrzejewski, Stefan. "Degradation of reticuline in Berberis suspension cultures." Phytochemistry 29, no. 1 (1990): 135–39. http://dx.doi.org/10.1016/0031-9422(90)89026-6.

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10

Arbain, D., N. Dasma, S. Ibrahim, and MV Sargent. "The Constituents of the Bark of Litsea elliptica (Lauraceae)." Australian Journal of Chemistry 43, no. 11 (1990): 1949. http://dx.doi.org/10.1071/ch9901949.

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11

Han, Xu, Marc Lamshöft, Nadja Grobe, et al. "The biosynthesis of papaverine proceeds via (S)-reticuline." Phytochemistry 71, no. 11-12 (2010): 1305–12. http://dx.doi.org/10.1016/j.phytochem.2010.04.022.

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12

Stadler, R., T. M. Kutchan, S. Loeffler, N. Nagakura, B. Cassels, and M. H. Zenk. "Revision of the early steps of reticuline biosynthesis." Tetrahedron Letters 28, no. 12 (1987): 1251–54. http://dx.doi.org/10.1016/s0040-4039(00)95338-3.

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13

Costa, Emmanoel V., Liviane do N. Soares, Jamal da Silva Chaar, et al. "Benzylated Dihydroflavones and Isoquinoline-Derived Alkaloids from the Bark of Diclinanona calycina (Annonaceae) and Their Cytotoxicities." Molecules 26, no. 12 (2021): 3714. http://dx.doi.org/10.3390/molecules26123714.

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Diclinanona calycina R. E. Fries popularly known as “envira”, is a species of the Annonaceae family endemic to Brazil. In our ongoing search for bioactive compounds from Annonaceae Amazon plants, the bark of D. calycina was investigated by classical chromatography techniques that yielded thirteen compounds (alkaloids and flavonoids) described for the first time in D. calycina as well as in the genus Diclinanona. The structure of these isolated compounds were established by extensive analysis using 1D/2D-NMR spectroscopy in combination with MS. The isolated alkaloids were identified as belongin

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14

Hewgill, FR, and MC Pass. "The Oxidation of (±)-Reticuline as Studied by E.S.R Spectroscopy." Australian Journal of Chemistry 38, no. 3 (1985): 497. http://dx.doi.org/10.1071/ch9850497.

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E.s.r. spectra obtained by oxidation of reticuline and closely related compounds in a flow system with cerium(IV) show chiefly the aryloxy radical derived from the 1-benzyl c-ring. The 4′-ethoxy homologue of norreticuline shows both A- and C-ring radicals in roughly equal proportions. The mechanism of intramolecular coupling is discussed, and as no evidence was obtained for the occurrence of a radical substitution reaction it is concluded that radical pairing is more likely, although this apparently happens too quickly for observation of a biradical species.

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15

KIM, Ju-Sung, Akira NAKAGAWA, Yuya YAMAZAKI, et al. "Improvement of Reticuline Productivity from Dopamine by Using EngineeredEscherichia coli." Bioscience, Biotechnology, and Biochemistry 77, no. 10 (2013): 2166–68. http://dx.doi.org/10.1271/bbb.130552.

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16

Diaz-Bárcena, Alba, Luis Fernandez-Pacios, and Patricia Giraldo. "Structural Characterization and Molecular Dynamics Study of the REPI Fusion Protein from Papaver somniferum L." Biomolecules 14, no. 1 (2023): 2. http://dx.doi.org/10.3390/biom14010002.

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REPI is a pivotal point enzyme in plant benzylisoquinoline alkaloid metabolism as it promotes the evolution of the biosynthetic branch of morphinan alkaloids. Experimental studies of its activity led to the identification of two modules (DRS and DRR) that catalyze two sequential steps of the epimerization of (S)- to (R)-reticuline. Recently, special attention has been paid to its genetic characterization and evolutionary history, but no structural analyses of the REPI protein have been conducted to date. We present here a computational structural characterization of REPI with heme and NADP cof

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17

NAKAOJI, Koichi, Hidekazu NAYESHIRO, and Takao TAKAHASHI. "Norreticuline and reticuline as possible new agents for hair growth acceleration." Biological & Pharmaceutical Bulletin 20, no. 5 (1997): 586–88. http://dx.doi.org/10.1248/bpb.20.586.

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18

Zhu, Wei, Yuliang Ma, Patrick Cadet, et al. "Presence of reticuline in rat brain: a pathway for morphine biosynthesis." Molecular Brain Research 117, no. 1 (2003): 83–90. http://dx.doi.org/10.1016/s0169-328x(03)00323-1.

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19

Fadaeinasab, Mehran, Hairin Taha, Putri Narrima Mohd Fauzi, Hapipah Mohd Ali, and Aty Widyawaruyanti. "Anti-malarial Activity of Isoquinoline Alkaloids from the Stem Bark of Actinodaphne macrophylla." Natural Product Communications 10, no. 9 (2015): 1934578X1501000. http://dx.doi.org/10.1177/1934578x1501000913.

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Seven isoquinoline alkaloids isolated from the bark of Actinodaphne macrophylla in this study demonstrated in vitro antiplasmodial activities against Plasmodium falciparum 3D7 with IC50 values of 0.08 μM, 0.05 μM, 1.18 μM, 3.11 μM, 0.65 μM, 0.26 μM, and 1.38 μM for cycleanine, 10-demethylxylopinine, reticuline, laurotetanine, bicuculine, α-hydrastine and anolobine, respectively, which are comparable with the reference standard, chloroquine. 10-Demethylxylopinine was found to be the most active of these compounds.

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20

Nema, Shrikant, Kanika Verma, Ashutosh Mani, Neha Shree Maurya, Archana Tiwari, and Praveen Kumar Bharti. "Identification of Potential Antimalarial Drug Candidates Targeting Falcipain-2 Protein of Malaria Parasite—A Computational Strategy." BioTech 11, no. 4 (2022): 54. http://dx.doi.org/10.3390/biotech11040054.

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Falcipain-2 (FP-2) is one of the main haemoglobinase of P. falciparum which is an important molecular target for the treatment of malaria. In this study, we have screened alkaloids to identify potential inhibitors against FP-2 since alkaloids possess great potential as anti-malarial agents. A total of 340 alkaloids were considered for the study using a series of computational pipelines. Initially, pharmacokinetics and toxicity risk assessment parameters were applied to screen compounds. Subsequently, molecular docking algorithms were utilised to understand the binding efficiency of alkaloids a

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21

DeLoache, William C., Zachary N. Russ, Lauren Narcross, Andrew M. Gonzales, Vincent J. J. Martin, and John E. Dueber. "An enzyme-coupled biosensor enables (S)-reticuline production in yeast from glucose." Nature Chemical Biology 11, no. 7 (2015): 465–71. http://dx.doi.org/10.1038/nchembio.1816.

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22

Loeffler, Susanne, and Meinhart H. Zenk. "The hydroxylation step in the biosynthetic pathway leading from norcoclaurine to reticuline." Phytochemistry 29, no. 11 (1990): 3499–503. http://dx.doi.org/10.1016/0031-9422(90)85264-g.

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23

Medeiros, Marcos Antônio A., Xirley P. Nunes, José M. Barbosa-Filho, et al. "(S)-reticuline induces vasorelaxation through the blockade of L-type Ca2+ channels." Naunyn-Schmiedeberg's Archives of Pharmacology 379, no. 2 (2008): 115–25. http://dx.doi.org/10.1007/s00210-008-0352-1.

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24

Mimi, Carolina Ovile, Iván De-la-Cruz-Chacón, Felipe Moura Araujo da Silva, Victor Cauan Rocha Roberto, and Gisela Ferreira. "Effect of Auxins on the Accumulation of Alkaloids in Ungrafted Annona emarginata (Schltdl.) H. Rainer and Annona emarginata (Schltdl.) H. Rainer Grafted with Annona atemoya Mabb." Molecules 30, no. 9 (2025): 2070. https://doi.org/10.3390/molecules30092070.

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Plant regulators, such as auxins, modulate the synthesis of specialized metabolites and aid in the bioprospection of molecules. Annona emarginata is known to produce antifungal alkaloids and serves as a rootstock for Annona atemoya. This study evaluated the effects of indoleacetic acid (IAA), indolebutyric acid (IBA), and naphthaleneacetic acid (NAA) applications on the accumulation of alkaloids in ungrafted A. emarginata and grafted with A. atemoya. Total alkaloids were analyzed by spectrophotometry, and alkaloid profiles were analyzed by DI-MS at 8, 14, and 20 days after treatments (DAT). Th

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25

Farrow, Scott C., Jillian M. Hagel, Guillaume A. W. Beaudoin, Darcy C. Burns, and Peter J. Facchini. "Stereochemical inversion of (S)-reticuline by a cytochrome P450 fusion in opium poppy." Nature Chemical Biology 11, no. 9 (2015): 728–32. http://dx.doi.org/10.1038/nchembio.1879.

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26

Ivanova, Bojidarka, and Michael Spiteller. "On the Biosynthetic Pathway of Papaverine via (S)-Reticuline – Theoretical vs. Experimental Study." Natural Product Communications 7, no. 5 (2012): 1934578X1200700. http://dx.doi.org/10.1177/1934578x1200700508.

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The electronic structures, optical properties and molecular structures of a series of isoquinoline alkaloids resulting in the formation of papaverine, through a proposed biosynthetic pathway via S(+)-reticuline were elucidated. The mechanism of papaverine synthesis was studied by electronic absorption, diffuse reflectance, fluorescence and CD spectroscopy, as well as ESI and MALDI Orbitrap imaging mass spectrometry. Quantum chemical DFT calculations in the gas phase and solution were performed with a view to study the electronic transitions of the interacting species, corresponding proposed in

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27

Winkler, Andreas, Martin Puhl, Hansjörg Weber, Toni M. Kutchan, Karl Gruber, and Peter Macheroux. "Berberine bridge enzyme catalyzes the six electron oxidation of (S)-reticuline to dehydroscoulerine." Phytochemistry 70, no. 9 (2009): 1092–97. http://dx.doi.org/10.1016/j.phytochem.2009.06.005.

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28

De-Eknamkul, W., and M. H. Zenk. "Enzymic formation of (R)-reticuline from 1,2-dehydroreticuline in the opium poppy plant." Tetrahedron Letters 31, no. 34 (1990): 4855–58. http://dx.doi.org/10.1016/s0040-4039(00)97751-7.

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29

Trenchard, Isis J., Michael S. Siddiqui, Kate Thodey, and Christina D. Smolke. "De novo production of the key branch point benzylisoquinoline alkaloid reticuline in yeast." Metabolic Engineering 31 (September 2015): 74–83. http://dx.doi.org/10.1016/j.ymben.2015.06.010.

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30

Morais, L. C. S. L., J. M. Barbosa-Filho, and R. N. Almeida. "Central depressant effects of reticuline extracted from Ocotea duckei in rats and mice." Journal of Ethnopharmacology 62, no. 1 (1998): 57–61. http://dx.doi.org/10.1016/s0378-8741(98)00044-0.

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31

Allen, Robert S., Anthony G. Millgate, Julie A. Chitty, et al. "RNAi-mediated replacement of morphine with the nonnarcotic alkaloid reticuline in opium poppy." Nature Biotechnology 22, no. 12 (2004): 1559–66. http://dx.doi.org/10.1038/nbt1033.

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32

Stadler, R., and M. Zenk. "The Trioxygenated Benzyltetrahydroisoquinoline Alkaloid Norcoclaurine is the Key Precursor of Reticuline-Derived Alkaloids." Planta Medica 55, no. 07 (1989): 677–78. http://dx.doi.org/10.1055/s-2006-962283.

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33

Gan, Li-She, Wei Yao, Jian-Xia Mo, and Chang-Xin Zhou. "Alkaloids from Lindera Aggregata." Natural Product Communications 4, no. 1 (2009): 1934578X0900400. http://dx.doi.org/10.1177/1934578x0900400111.

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Eight alkaloids, including a new compound, (+)-norboldine acetate (1), and seven known ones, (+)-norboldine (2), (+)-boldine (3), (+)-laurotetanine (4), (+)- N-methyllaurotetanine (5), (+)-reticuline (6), (–)-pronuciferine (7), and pallidine (8) were isolated from the roots of Lindera aggregata. The structures of these alkaloids were determined by spectroscopic and chemical methods, especially 2D NMR techniques, which also allowed the first full NMR assignments of alkaloids 2, 4 and 5. Among them, the 1D NMR chemical shifts of (+)-norboldine (2) showed a remarkable environmental sensitive beha

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34

Nakagawa, Akira, Shinya Nakamura, Eitaro Matsumura, et al. "Selection of the optimal tyrosine hydroxylation enzyme for (S)-reticuline production in Escherichia coli." Applied Microbiology and Biotechnology 105, no. 13 (2021): 5433–47. http://dx.doi.org/10.1007/s00253-021-11401-z.

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35

Al-Amri, A. M., R. M. Smith, B. M. El-Haj, and M. H. Juma’a. "The GC–MS detection and characterization of reticuline as a marker of opium use." Forensic Science International 140, no. 2-3 (2004): 175–83. http://dx.doi.org/10.1016/j.forsciint.2003.10.022.

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36

Al-Amri, A. M., R. M. Smith, B. M. El-Haj, and M. H. Juma’a. "The GC–MS detection and characterization of reticuline as a marker of opium use." Forensic Science International 142, no. 1 (2004): 61–69. http://dx.doi.org/10.1016/j.forsciint.2004.02.006.

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37

Mohd Nuzul Hakimi Wan Salleh, Wan, Natasa Mohd Shakri, Mohd Azlan Nafiah, et al. "Chemical constituents of the leaves of Actinodaphne pruinosa." Bulletin of the Chemical Society of Ethiopia 36, no. 4 (2022): 963–69. http://dx.doi.org/10.4314/bcse.v36i4.20.

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ABSTRACT. This study was designed to investigate the chemical constituents from Actinodaphne pruinosa growing in Malaysia. A phytochemical investigation of the leaves part resulted in the isolation of boldine (1), norboldine (2), laurotetanine (3), reticuline (4), syringaresinol (5), lupeol (6), and taraxerol (7). The structures of the isolated phytochemicals were established by analysis of their spectroscopic data, as well as the comparison with that of reported data. Notably, this is the first time to report the isolation and structural elucidation of the constituents from the leaves part of

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38

Cahlíková, Lucie, Kateřina Macáková, Jiří Kuneš, et al. "Acetylcholinesterase and Butyrylcholinesterase Inhibitory Compounds from Eschscholzia californica (Papaveraceae)." Natural Product Communications 5, no. 7 (2010): 1934578X1000500. http://dx.doi.org/10.1177/1934578x1000500710.

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The roots and aerial parts of Eschscholzia californica Cham. (Papaveraceae) were extracted with ethanol. Repeated column chromatography, preparative TLC, and crystallization led to the isolation of fourteen isoquinoline alkaloids, the structures of which were determined on the basis of spectroscopic techniques and by comparison with literature values. One of the compounds isolated, 1-(3-hydroxy-4-methoxybenzyl)-2-methyl-6,7-methylenedioxy-1,2,3,4-tetrahydroisoquinoline (14), has not previously been isolated from a natural source. All isolated compounds were tested for human blood acetylcholine

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39

Slishchuk, H., V. I. Meshcheryakov, N. E. Volkova, and O. A. Zakharova. "Mexican argemone (Argemone mexicana L.) CYP719A14 protein bioinformatic analysis." Faktori eksperimental'noi evolucii organizmiv 32 (September 1, 2023): 155–59. http://dx.doi.org/10.7124/feeo.v32.1553.

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CYP719A14 structure analysis and its interaction with ligands via bioinformatic methods. Methods. Homologous modeling of three-dimensional structure of enzyme. Molecular docking. Results. CYP719A14 enzyme, which shows cheilanthifoline synthase activity, model was build based on results of homologous modeling. Interaction of built model with possible substrates – benzylisoquinoline compounds: (S)-Scoulerine, (S)-Cheilanthifoline, (S)-Tetrahydrocolumbamine, (S)-Reticuline was investigated using molecular docking method, thermodynamic characteristics of interaction were calculated. Potential Liga

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40

Schneider, B., and Meinhart H. Zenk. "Metabolism of (S)-reticuline in an alkaloid non-producing cell culture strain of Thalictrum tuberosum." Phytochemistry 33, no. 6 (1993): 1431–35. http://dx.doi.org/10.1016/0031-9422(93)85104-y.

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41

Stadler, Richard, and Meinhart H. Zenk. "A revision of the generally accepted pathway for the biosynthesis of the benzyltetrahydroisoquinoline alkaloid reticuline." Liebigs Annalen der Chemie 1990, no. 6 (1990): 555–62. http://dx.doi.org/10.1002/jlac.1990199001104.

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42

Mutakin, Mutakin, Rizky Fauziati, Fahrina Nur Fadhilah, Ade Zuhrotun, Riezki Amalia, and Yuni Elsa Hadisaputri. "Pharmacological Activities of Soursop (Annona muricata Lin.)." Molecules 27, no. 4 (2022): 1201. http://dx.doi.org/10.3390/molecules27041201.

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Soursop (Annona muricata Lin.) is a plant belonging to the Annonaceae family that has been widely used globally as a traditional medicine for many diseases. In this review, we discuss the traditional use, chemical content, and pharmacological activities of A.muricata. From 49 research articles that were obtained from 1981 to 2021, A.muricata’s activities were shown to include anticancer (25%), antiulcer (17%), antidiabetic (14%), antiprotozoal (10%), antidiarrhea (8%), antibacterial (8%), antiviral (8%), antihypertensive (6%), and wound healing (4%). Several biological activities and the gener

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43

Hošt'álková, Anna, Lubomír Opletal, Jiří Kuneš, et al. "Alkaloids from Peumus boldus and their Acetylcholinesterase, Butyrylcholinesterase and Prolyl Oligopeptidase Inhibition Activity." Natural Product Communications 10, no. 4 (2015): 1934578X1501000. http://dx.doi.org/10.1177/1934578x1501000410.

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Eleven isoquinoline alkaloids (1–11) were isolated from dried leaves of Peumus boldus Mol. by standard chromatographic methods. The chemical structures were elucidated by MS, and 1D and 2D NMR spectroscopic analysis, and by comparison with literature data. Compounds isolated in sufficient amount were evaluated for their acetylcholinesterase, and butyrylcholinesterase inhibition activity using Ellman's method. In the prolyl oligopeptidase assay, Z-Gly-Pro- p-nitroanilide was used as substrate. Promising butyrylcholinesterase inhibition activities were demonstrated by two benzylisoquinoline alka

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44

Schmidt, Jürgen, Klaus Raith, Chotima Boettcher, and Meinhart H. Zenk. "Analysis of Benzylisoquinoline-Type Alkaloids by Electrospray Tandem Mass Spectrometry and Atmospheric Pressure Photoionization." European Journal of Mass Spectrometry 11, no. 3 (2005): 325–33. http://dx.doi.org/10.1255/ejms.745.

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Benzylisoquinoline alkaloids found in the Papaveraceae family play a major role in pharmaceutical biology. This is the first systematic study dealing with electrospray tandem mass spectrometry (ESI-MS/MS) of all benzylisoquinolines found as biogenetic precursors of morphinan alkaloids. Tandem mass spectral data are presented for norlaudanosoline, laudanosoline, 4′- O-methyl-norlaudanosoline, 6- O-methyl-norlaudanosoline, norcoclaurine, coclaurine, N-methylcoclaurine, N-methyl-3′-hydroxycoclaurine, N-methyl-3′- O-methylcoclaurine, norreticuline and reticuline. This study compares results obtain

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45

Riley-Saldaña, Christian Anabí, María del Rocío Cruz-Ortega, Mariano Martínez Vázquez, Iván De-la-Cruz-Chacón, Marisol Castro-Moreno, and Alma Rosa González-Esquinca. "Acetogenins and alkaloids during the initial development of Annona muricata L. (Annonaceae)." Zeitschrift für Naturforschung C 72, no. 11-12 (2017): 497–506. http://dx.doi.org/10.1515/znc-2017-0060.

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AbstractIn plants, the presence and distribution of specialized metabolites during the early stages of development are not documented enough, even though their biosynthesis is one of the most important strategies for survival. In this study, five alkaloids and four acetogenins were detected inAnnona muricataL. during early development seedling, including three phases of root emergence and three of seedling formation. Hexane and alkaloid extracts were obtained from each organ, which were analyzed in a gas-mass chromatograph and in a high-performance liquid chromatograph coupled with a photodiod

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Matsumura, Eitaro, Akira Nakagawa, Yusuke Tomabechi, et al. "Laboratory-scale production of (S)-reticuline, an important intermediate of benzylisoquinoline alkaloids, using a bacterial-based method." Bioscience, Biotechnology, and Biochemistry 81, no. 2 (2016): 396–402. http://dx.doi.org/10.1080/09168451.2016.1243985.

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Gerardy, Roswitha, and Meinhart H. Zenk. "Formation of salutaridine from (R)-reticuline by a membrane-bound cytochrome P-450 enzyme from Papaver somniferum." Phytochemistry 32, no. 1 (1992): 79–86. http://dx.doi.org/10.1016/0031-9422(92)80111-q.

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Alassani, Faїza, Vincent Yapo, Issouf Bamba, Duni Sawadogo, and Michel Honde. "Mise en evidence des altérations de la moelle osseuse par la coloration de la reticuline à Abidjan." International Journal of Biological and Chemical Sciences 18, no. 5 (2025): 1673–83. https://doi.org/10.4314/ijbcs.v18i5.4.

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La biopsie ostéo-médullaire associée à l’étude histologique reste un atout majeur dans la mise en évidence des pathologies de la moelle osseuse. L’objectif de cette étude était de montrer l’intérêt de la biopsie ostéo-medullaire colorée à la réticuline dans le diagnostic de ces affections. Une étude transversale a eu pour cadre le laboratoire central du Plateau et l’UFR des Sciences Pharmaceutiques et Biologiques d’Abidjan. Elle a réuni 35 blocs d’inclusion à paraffine contenant des biopsies ostéo-médullaires (BOM) sur lesquels des coupes histologiques ont été réalisées. Les colorations d’héma

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Wat, Chi-Kit, Paul Steffens та Meinhart H. Zenk. "Partial Purification and Characterization of S-Adenosyl-ʟ-Methionine: Norreticuline N-Methyltransferases from Berberis Cell Suspension Cultures". Zeitschrift für Naturforschung C 41, № 1-2 (1986): 126–34. http://dx.doi.org/10.1515/znc-1986-1-219.

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Abstract Two new N-methyltransferases (NMT-I and NMT-II) were found to occur in Berberis vulgaris cell suspension cultures. One of these enzymes (NMT-I) was partially purified (100-fold) and characterized. This enzyme is specific for tetrahydrobenzylisoquinoline alkaloids and S-adenosyl-ʟ-methionine serves as the methyl donor. The apparent molecular weight of the enzyme is 68,000. The pH optimum of the enzyme is 7.6, the temperature optimum 35 °C. Apparent KM values for (R)-tetrahydropapaverin as substrate were 0.2 mᴍ and for SAM 0.04 mᴍ. The preparation of the same type of enzyme from B. wils

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Dholvitayakhun, Achara, Nathanon Trachoo, Nual-anong Narkkong, and T. P. Tim Cushnie. "Using scanning and transmission electron microscopy to investigate the antibacterial mechanism of action of the medicinal plant Annona squamosa Linn." Journal of Herbal Medicine 7, no. 1 (2016): 31–36. https://doi.org/10.1016/j.hermed.2016.10.003.

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Leaves of <em>Annona squamosa</em> Linn. (Annonaceae), used in traditional medicine for infection treatment and prevention, have been shown to possess antibacterial activity in several recent studies. We examined the effect of the active reticuline-containing fraction of this traditional medicine on bacterial cell ultrastructure to gain insight into its mechanism of action. <em>Bacillus cereus</em> and <em>Campylobacter jejuni</em> were used as representative species of Gram-positive and Gram-negative pathogen. Time-kill assays were performed with each bacterial species and 1xMIC (minimum inhi

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