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Relevant bibliographies by topics / RETINA, RETINAL DEGENERATION, IRON, DRUG DELIVERY

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Journal articles

Academic literature on the topic 'RETINA, RETINAL DEGENERATION, IRON, DRUG DELIVERY'

Author: Grafiati

Published: 9 March 2023

Last updated: 10 March 2023

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Journal articles on the topic "RETINA, RETINAL DEGENERATION, IRON, DRUG DELIVERY"

1

Eblimit, Aiden, Mustafa S. Makia, Daniel Strayve, et al. "Co-Injection of Sulfotyrosine Facilitates Retinal Uptake of Hyaluronic Acid Nanospheres Following Intravitreal Injection." Pharmaceutics 13, no. 9 (2021): 1510. http://dx.doi.org/10.3390/pharmaceutics13091510.

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Gene and drug delivery to the retina is a critical therapeutic goal. While the majority of inherited forms of retinal degeneration affect the outer retina, specifically the photoreceptors and retinal pigment epithelium, effective targeted delivery to this region requires invasive subretinal delivery. Our goal in this work was to evaluate two innovative approaches for increasing both the persistence of delivered nanospheres and their penetration into the outer retina while using the much less invasive intravitreal delivery method. We formulated novel hyaluronic acid nanospheres (HA-NS, 250 nm a

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2

Souto, Eliana B., Elena Sanchez-Lopez, Joana R. Campos, et al. "Retinal Drug Delivery: Rethinking Outcomes for the Efficient Replication of Retinal Behavior." Applied Sciences 10, no. 12 (2020): 4258. http://dx.doi.org/10.3390/app10124258.

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The retina is a highly organized structure that is considered to be "an approachable part of the brain." It is attracting the interest of development scientists, as it provides a model neurovascular system. Over the last few years, we have been witnessing significant development in the knowledge of the mechanisms that induce the shape of the retinal vascular system, as well as knowledge of disease processes that lead to retina degeneration. Knowledge and understanding of how our vision works are crucial to creating a hardware-adaptive computational model that can replicate retinal behavior. Th

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3

Batabyal, Subrata, Sivakumar Gajjeraman, Sulagna Bhattacharya, Weldon Wright, and Samarendra Mohanty. "Nano-enhanced Optical Gene Delivery to Retinal Degenerated Mice." Current Gene Therapy 19, no. 5 (2019): 318–29. http://dx.doi.org/10.2174/1566523219666191017114044.

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Background: The efficient and targeted delivery of genes and other impermeable therapeutic molecules into retinal cells is of immense importance for the therapy of various visual disorders. Traditional methods for gene delivery require viral transfection, or chemical methods that suffer from one or many drawbacks, such as low efficiency, lack of spatially targeted delivery, and can generally have deleterious effects, such as unexpected inflammatory responses and immunological reactions. Methods: We aim to develop a continuous wave near-infrared laser-based Nano-enhanced Optical Delivery (NOD)

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4

Bigot, Karine, Pauline Gondouin, Romain Bénard, et al. "Transferrin Non-Viral Gene Therapy for Treatment of Retinal Degeneration." Pharmaceutics 12, no. 9 (2020): 836. http://dx.doi.org/10.3390/pharmaceutics12090836.

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Dysregulation of iron metabolism is observed in animal models of retinitis pigmentosa (RP) and in patients with age-related macular degeneration (AMD), possibly contributing to oxidative damage of the retina. Transferrin (TF), an endogenous iron chelator, was proposed as a therapeutic candidate. Here, the efficacy of TF non-viral gene therapy based on the electrotransfection of pEYS611, a plasmid encoding human TF, into the ciliary muscle was evaluated in several rat models of retinal degeneration. pEYS611 administration allowed for the sustained intraocular production of TF for at least 3 and

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5

Kim, Hyeong Min, and Se Joon Woo. "Ocular Drug Delivery to the Retina: Current Innovations and Future Perspectives." Pharmaceutics 13, no. 1 (2021): 108. http://dx.doi.org/10.3390/pharmaceutics13010108.

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Treatment options for retinal diseases, such as neovascular age-related macular degeneration, diabetic retinopathy, and retinal vascular disorders, have markedly expanded following the development of anti-vascular endothelial growth factor intravitreal injection methods. However, because intravitreal treatment requires monthly or bimonthly repeat injections to achieve optimal efficacy, recent investigations have focused on extended drug delivery systems to lengthen the treatment intervals in the long term. Dose escalation and increasing molecular weight of drugs, intravitreal implants and nano

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6

Nishida, Shogo, Yuuki Takashima, Ryotaro Udagawa, Hisako Ibaraki, Yasuo Seta, and Hiroshi Ishihara. "A Multifunctional Hybrid Nanocarrier for Non-Invasive siRNA Delivery to the Retina." Pharmaceutics 15, no. 2 (2023): 611. http://dx.doi.org/10.3390/pharmaceutics15020611.

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Drug therapy for retinal diseases (e.g., age-related macular degeneration, the leading cause of blindness) is generally performed by invasive intravitreal injection because of poor drug delivery caused by the blood–retinal barrier (BRB). This study aimed to develop a nanocarrier for the non-invasive delivery of small interfering RNA (siRNA) to the posterior segment of the eye (i.e., the retina) by eyedrops. To this end, we prepared a hybrid nanocarrier based on a multifunctional peptide and liposomes, and the composition was optimized. A cytoplasm-responsive stearylated peptide (STR-CH2R4H2C)

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7

Bassetto, Marco, Daniel Ajoy, Florent Poulhes, et al. "Magnetically Assisted Drug Delivery of Topical Eye Drops Maintains Retinal Function In Vivo in Mice." Pharmaceutics 13, no. 10 (2021): 1650. http://dx.doi.org/10.3390/pharmaceutics13101650.

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Barded-Biedl syndrome (BBS) is a rare genetic disorder with an unmet medical need for retinal degeneration. Small-molecule drugs were previously identified to slow down the apoptosis of photoreceptors in BBS mouse models. Clinical translation was not practical due to the necessity of repetitive invasive intravitreal injections for pediatric populations. Non-invasive methods of retinal drug targeting are a prerequisite for acceptable adaptation to the targeted pediatric patient population. Here, we present the development and functional testing of a non-invasive, topical, magnetically assisted

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8

Huang, Li, Wentao Liang, Kelu Zhou, et al. "Therapeutic Effects of Fenofibrate Nano-Emulsion Eye Drops on Retinal Vascular Leakage and Neovascularization." Biology 10, no. 12 (2021): 1328. http://dx.doi.org/10.3390/biology10121328.

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Macular edema caused by retinal vascular leakage and ocular neovascularization are the leading causes of severe vision loss in diabetic retinopathy (DR) and age-related macular degeneration (AMD) patients. Oral administration of fenofibrate, a PPARα agonist, has shown therapeutic effects on macular edema and retinal neovascularization in diabetic patients. To improve the drug delivery to the retina and its efficacy, we have developed a nano-emulsion-based fenofibrate eye drop formulation that delivered significantly higher amounts of the drug to the retina compared to the systemic administrati

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9

Hsueh, Henry T., Yoo-Chun Kim, Ian Pitha, et al. "Ion-Complex Microcrystal Formulation Provides Sustained Delivery of a Multimodal Kinase Inhibitor from the Subconjunctival Space for Protection of Retinal Ganglion Cells." Pharmaceutics 13, no. 5 (2021): 647. http://dx.doi.org/10.3390/pharmaceutics13050647.

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Glaucoma is the leading cause of irreversible blindness worldwide. Elevated intraocular pressure (IOP) is one of the major risk factors for glaucoma onset and progression, and available pharmaceutical interventions are exclusively targeted at IOP lowering. However, degeneration of retinal ganglion cells (RGCs) may continue to progress despite extensive lowering of IOP. A complementary strategy to IOP reduction is the use of neuroprotective agents that interrupt the process of cell death by mechanisms independent of IOP. Here, we describe an ion complexation approach for formulating microcrysta

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10

Tolone, Arianna, Soumaya Belhadj, Andreas Rentsch, Frank Schwede, and François Paquet-Durand. "The cGMP Pathway and Inherited Photoreceptor Degeneration: Targets, Compounds, and Biomarkers." Genes 10, no. 6 (2019): 453. http://dx.doi.org/10.3390/genes10060453.

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Photoreceptor physiology and pathophysiology is intricately linked to guanosine-3’,5’-cyclic monophosphate (cGMP)-signaling. Here, we discuss the importance of cGMP-signaling for the pathogenesis of hereditary retinal degeneration. Excessive accumulation of cGMP in photoreceptors is a common denominator in cell death caused by a variety of different gene mutations. The cGMP-dependent cell death pathway may be targeted for the treatment of inherited photoreceptor degeneration, using specifically designed and formulated inhibitory cGMP analogues. Moreover, cGMP-signaling and its down-stream targ

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